Publications by authors named "Frank R Vleugels"

4 Publications

  • Page 1 of 1

An atypical case of ectopic extramammary Paget disease presenting on the lateral neck.

JAAD Case Rep 2019 Oct 25;5(10):868-870. Epub 2019 Sep 25.

Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jdcr.2019.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804557PMC
October 2019

Examining the epidemiology of coincident psoriasis and sarcoidosis: An observational cross-sectional study.

J Am Acad Dermatol 2018 Nov 14. Epub 2018 Nov 14.

Department of Dermatology, Brigham and Women's Hospital, Boston, Massachusetts. Electronic address:

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaad.2018.11.009DOI Listing
November 2018

Metastatic eccrine porocarcinoma after Mohs micrographic surgery: a case report.

J Clin Oncol 2012 Jul 11;30(21):e188-91. Epub 2012 Jun 11.

University of Cincinnati School of Medicine, Cincinnati, OH, USA.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1200/JCO.2011.40.6843DOI Listing
July 2012

Resveratrol-sensitized UVA induced apoptosis in human keratinocytes through mitochondrial oxidative stress and pore opening.

J Photochem Photobiol B 2012 Aug 18;113:42-50. Epub 2012 May 18.

Southern Arizona VA Health Care System, Tucson, AZ 85724, USA.

Resveratrol (3,5,4'-trihydroxy-trans-stilbene), a polyphenol compound, is derived from natural products such as the skin of red grapes, blueberries and cranberries. Resveratrol not only exhibits antioxidant, cardioprotection, and anti-aging properties, but can also inhibit cancer cell growth and induce apoptosis. It has been shown that resveratrol inhibits the activation of Nf-κB and subsequently down regulates the expression of Nf-κB regulated genes such as interleukin-2 and Bcl-2, leading to cell cycle arrest and increased apoptosis in multiple myeloma cells. In the skin, resveratrol has been reported to sensitize keratinocytes to UVA induced apoptosis. However, the effect of resveratrol on opening of the mitochondrial permeability transition pore has not been previously examined. Our data show that UVA (14 J/cm(2)) along with resveratrol causes massive oxidative stress in mitochondria. As a consequence of oxidative stress, the mitochondrial membrane potential decreases which results in opening of the mitochondrial pores ultimately leading to apoptosis in human keratinocytes. These results may have clinical implications for development of future chemotherapeutic treatment for tumors of the skin.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jphotobiol.2012.04.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3394459PMC
August 2012