Frank Peelman

Frank Peelman

UNVERIFIED PROFILE

Are you Frank Peelman?   Register this Author

Register author
Frank Peelman

Frank Peelman

Publications by authors named "Frank Peelman"

Are you Frank Peelman?   Register this Author

52Publications

789Reads

36Profile Views

The Small GTPase Arf6: An Overview of Its Mechanisms of Action and of Its Role in Host⁻Pathogen Interactions and Innate Immunity.

Int J Mol Sci 2019 May 5;20(9). Epub 2019 May 5.

Cytokine Receptor Laboratory, Flanders Institute of Biotechnology, VIB-UGent Center for Medical Biotechnology, Faculty of Medicine and Health Sciences, Ghent University, 9000 Ghent, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms20092209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6539230PMC
May 2019

Straightforward Protein-Protein Interaction Interface Mapping via Random Mutagenesis and Mammalian Protein Protein Interaction Trap (MAPPIT).

Int J Mol Sci 2019 Apr 26;20(9). Epub 2019 Apr 26.

Cytokine Receptor Laboratory, Flanders Institute of Biotechnology, VIB-UGent Center for Medical Biotechnology, Faculty of Medicine and Health Sciences, Ghent University, 9000 Ghent, Belgium.

View Article

Download full-text PDF

Source
https://www.mdpi.com/1422-0067/20/9/2058
Publisher Site
http://dx.doi.org/10.3390/ijms20092058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6539206PMC
April 2019

Virtual screening for inhibitors of the human TSLP:TSLPR interaction.

Sci Rep 2017 12 8;7(1):17211. Epub 2017 Dec 8.

Laboratory of Medicinal Chemistry, University of Antwerp, 2610, Wilrijk, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-017-17620-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722893PMC
December 2017

TYK2-induced phosphorylation of Y640 suppresses STAT3 transcriptional activity.

Sci Rep 2017 Nov 21;7(1):15919. Epub 2017 Nov 21.

Receptor Research Laboratories, Cytokine Receptor Lab, VIB-UGent Center for Medical Biotechnology, 9000, Ghent, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-017-15912-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698428PMC
November 2017

RNF41 interacts with the VPS52 subunit of the GARP and EARP complexes.

PLoS One 2017 22;12(5):e0178132. Epub 2017 May 22.

Cytokine Receptor Laboratory, Department of Biochemistry, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0178132PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5439944PMC
September 2017

NR5A1 is a novel disease gene for 46,XX testicular and ovotesticular disorders of sex development.

Genet Med 2017 04 4;19(4):367-376. Epub 2016 Aug 4.

Department of Pediatrics, Division of Pediatric Endocrinology, Ghent University Hospital and Ghent University, Ghent, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/gim.2016.118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392598PMC
April 2017

Reconstructing the TIR Side of the Myddosome: a Paradigm for TIR-TIR Interactions.

Structure 2016 Mar 11;24(3):437-47. Epub 2016 Feb 11.

Department of Medical Protein Research, Cytokine Receptor Lab, VIB, A. Baertsoenkaai 3, 9000 Ghent, Belgium; Department of Biochemistry, Faculty of Medicine and Health Sciences, Ghent University, 9000 Ghent, Belgium. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.str.2015.12.018DOI Listing
March 2016

Leptin: From structural insights to the design of antagonists.

Life Sci 2015 Nov 19;140:49-56. Epub 2015 May 19.

Flanders Institute for Biotechnology (VIB), Department of Medical Protein Research, Faculty of Medicine and Health Sciences, Ghent University, A. Baertsoenkaai 3, 9000 Ghent, Belgium. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.lfs.2015.04.015DOI Listing
November 2015

Leptin's metabolic and immune functions can be uncoupled at the ligand/receptor interaction level.

Cell Mol Life Sci 2015 Feb 7;72(3):629-644. Epub 2014 Aug 7.

Department of Medical Protein Research, Faculty of Medicine and Health Sciences, Flanders Institute for Biotechnology, Ghent University, A. Baertsoenkaai 3, 9000, Ghent, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00018-014-1697-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4293488PMC
February 2015

20 years of leptin: insights into signaling assemblies of the leptin receptor.

J Endocrinol 2014 Oct 25;223(1):T9-23. Epub 2014 Jul 25.

Department of Medical Protein ResearchFaculty of Medicine and Health Sciences, Flanders Institute for Biotechnology (VIB), Ghent University, A. Baertsoenkaai 3, 9000 Ghent, BelgiumUnit for Structural BiologyLaboratory for Protein Biochemistry and Biomolecular Engineering (L-ProBE), Ghent University, K.L. Ledeganckstraat 35, 9000 Ghent, Belgium

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1530/JOE-14-0264DOI Listing
October 2014

Structural and mechanistic paradigm of leptin receptor activation revealed by complexes with wild-type and antagonist leptins.

Structure 2014 Jun 29;22(6):866-77. Epub 2014 May 29.

Unit for Structural Biology, Laboratory for Protein Biochemistry and Biomolecular Engineering (L-ProBE), Ghent University, 9000 Ghent, Belgium. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.str.2014.04.012DOI Listing
June 2014

Structural basis of the proinflammatory signaling complex mediated by TSLP.

Nat Struct Mol Biol 2014 Apr 16;21(4):375-82. Epub 2014 Mar 16.

Unit for Structural Biology, Laboratory for Protein Biochemistry and Biomolecular Engineering, Department of Biochemistry & Microbiology, Ghent University, Ghent, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nsmb.2794DOI Listing
April 2014

The small GTPase Arf6 is essential for the Tram/Trif pathway in TLR4 signaling.

J Biol Chem 2014 Jan 2;289(3):1364-76. Epub 2013 Dec 2.

From the Department of Medical Protein Research, Cytokine Receptor Lab, VIB, Ghent B-9000, Belgium.

View Article

Download full-text PDF

Source
http://www.jbc.org/lookup/doi/10.1074/jbc.M113.499194
Publisher Site
http://dx.doi.org/10.1074/jbc.M113.499194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894321PMC
January 2014

Reciprocal cross-regulation between RNF41 and USP8 controls cytokine receptor sorting and processing.

J Cell Sci 2013 Aug 7;126(Pt 16):3770-81. Epub 2013 Jun 7.

Department of Medical Protein Research, Flanders Interuniversity Institute for Biotechnology (VIB), Albert Baertsoenkaai 3, B-9000 Ghent, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1242/jcs.131250DOI Listing
August 2013

ROCKing the JAKs.

JAKSTAT 2013 Jul 15;2(3):e24074. Epub 2013 Aug 15.

Department of Medical Protein Research; VIB; Ghent, Belgium ; Department of Biochemistry; Faculty of Medicine and Health Sciences; Ghent University; Ghent, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4161/jkst.24074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772103PMC
July 2013

Identification of binding sites for myeloid differentiation primary response gene 88 (MyD88) and Toll-like receptor 4 in MyD88 adapter-like (Mal).

J Biol Chem 2013 Apr 4;288(17):12054-66. Epub 2013 Mar 4.

Department of Medical Protein Research, Flanders Interuniversity Institute for Biotechnology, VIB and Ghent University, B-9000 Ghent, Belgium.

View Article

Download full-text PDF

Source
http://www.jbc.org/lookup/doi/10.1074/jbc.M112.415810
Publisher Site
http://dx.doi.org/10.1074/jbc.M112.415810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636891PMC
April 2013

MAPPIT: a protein interaction toolbox built on insights in cytokine receptor signaling.

Cytokine Growth Factor Rev 2011 Oct-Dec;22(5-6):321-9. Epub 2011 Nov 25.

Department of Medical Protein Research, VIB, A. Baertsoenkaai 3, 9000 Ghent, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cytogfr.2011.11.001DOI Listing
April 2012

Identification of interaction sites for dimerization and adapter recruitment in Toll/interleukin-1 receptor (TIR) domain of Toll-like receptor 4.

J Biol Chem 2012 Feb 2;287(6):4088-98. Epub 2011 Dec 2.

Department of Medical Protein Research, Unit of Molecular Signal Transduction in Inflammation, Flanders Interuniversity Institute for Biotechnology, Ghent University, B-9000 Ghent, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M111.282350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281722PMC
February 2012

Selection of non-competitive leptin antagonists using a random nanobody-based approach.

Biochem J 2012 Jan;441(1):425-34

Flanders Institute for Biotechnology, Department of Medical Protein Research, Ghent University, Faculty of Medicine and Health Sciences, A. Baertsoenkaai 3, 9000 Ghent, Belgium.

View Article

Download full-text PDF

Source
http://www.biochemj.org/content/ppbiochemj/441/1/425.full.pd
Web Search
http://biochemj.org/lookup/doi/10.1042/BJ20110438
Publisher Site
http://dx.doi.org/10.1042/BJ20110438DOI Listing
January 2012

The metabolism of triglyceride-rich lipoproteins revisited: new players, new insight.

Atherosclerosis 2010 Jul 29;211(1):1-8. Epub 2009 Dec 29.

Department of Experimental Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.atherosclerosis.2009.12.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3924774PMC
July 2010

Definition of the interacting interfaces of Apobec3G and HIV-1 Vif using MAPPIT mutagenesis analysis.

Nucleic Acids Res 2010 Apr 16;38(6):1902-12. Epub 2009 Dec 16.

Department of Medical Protein Research, VIB, Department of Biochemistry, Ghent University, A. Baertsoenkaai 3, 9000 Ghent.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gkp1154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2847223PMC
April 2010

The many faces of the SOCS box.

Cytokine Growth Factor Rev 2008 Oct-Dec;19(5-6):371-81. Epub 2008 Oct 22.

Department of Medical Protein Research, VIB, Department of Biochemistry, Faculty of Medicine and Health Sciences, Ghent University, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cytogfr.2008.08.006DOI Listing
February 2009

Functional characterization of naturally occurring pathogenic mutations in the human leptin receptor.

Endocrinology 2008 Dec 14;149(12):6043-52. Epub 2008 Aug 14.

University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge CB2 0QQ, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/en.2008-0544DOI Listing
December 2008

Elongin B/C recruitment regulates substrate binding by CIS.

J Biol Chem 2008 Aug 28;283(31):21334-46. Epub 2008 May 28.

Department of Medical Protein Research, Flanders Institute for Biotechnology (VIB), Ghent University, A. Baertsoenkaai 3, Ghent, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M803742200DOI Listing
August 2008

Mammalian protein-protein interaction trap (MAPPIT) analysis of STAT5, CIS, and SOCS2 interactions with the growth hormone receptor.

Mol Endocrinol 2007 Nov 31;21(11):2821-31. Epub 2007 Jul 31.

Flanders Interuniversity Institute for Biotechnology, Department of Medical Protein Research, Ghent University, Faculty of Medicine and Health Sciences, A. Baertsoenkaai 3, B-9000 Ghent, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/me.2006-0541DOI Listing
November 2007

MAPPIT analysis of TLR adaptor complexes.

FEBS Lett 2007 Feb 18;581(4):629-36. Epub 2007 Jan 18.

Flanders Institute for Biotechnology (VIB), Department of Medical Protein Research, Faculty of Medicine and Health Sciences, Ghent University, A. Baertsoenkaai 3, B-9000 Ghent, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.febslet.2007.01.026DOI Listing
February 2007

The C-terminus of CIS defines its interaction pattern.

Biochem J 2007 Jan;401(1):257-67

Flanders Interuniversity Institute for Biotechnology, Department of Medical Protein Research (VIB09), Faculty of Medicine and Health Sciences, Ghent University, Baertsoenkaai 3, 9000 Ghent, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1042/BJ20060242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1698688PMC
January 2007

Functional cross-modulation between SOCS proteins can stimulate cytokine signaling.

J Biol Chem 2006 Nov 6;281(44):32953-66. Epub 2006 Sep 6.

Flanders Interuniversity Institute for Biotechnology, Department of Medical Protein Research, Faculty of Medicine and Health Sciences, Ghent University, B-9000 Ghent, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M600776200DOI Listing
November 2006

Mapping of binding site III in the leptin receptor and modeling of a hexameric leptin.leptin receptor complex.

J Biol Chem 2006 Jun 15;281(22):15496-504. Epub 2006 Mar 15.

Department of Medical Protein Research, Flanders Interuniversity Institute for Biotechnology, Ghent, Belgium.

View Article

Download full-text PDF

Source
http://www.jbc.org/lookup/doi/10.1074/jbc.M512622200
Publisher Site
http://dx.doi.org/10.1074/jbc.M512622200DOI Listing
June 2006

Techniques: new pharmacological perspectives for the leptin receptor.

Trends Pharmacol Sci 2006 Apr 14;27(4):218-25. Epub 2006 Mar 14.

Flanders Interuniversity Institute for Biotechnology, VIB09, Department of Medical Protein Research, Faculty of Medicine and Health Sciences, Ghent University, Albert Baertsonenkaai 3, B-9000 Ghent, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tips.2006.02.009DOI Listing
April 2006

Leptin receptor activation depends on critical cysteine residues in its fibronectin type III subdomains.

J Biol Chem 2005 Jun 18;280(24):22632-40. Epub 2005 Apr 18.

Department of Medical Protein Research, Faculty of Medicine and Health Sciences, Flanders Interuniversity Institute for Biotechnology, VIB09, Ghent University, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M413308200DOI Listing
June 2005

Mapping of the interface between leptin and the leptin receptor CRH2 domain.

J Cell Sci 2005 Jun;118(Pt 11):2519-27

Flanders Interuniversity Institute for Biotechnology, Department of Medical Protein Research (VIB09), Ghent University, Faculty of Medicine and Health Sciences, Baertsoenkaai 3, 9000 Ghent, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1242/jcs.02386DOI Listing
June 2005

Mapping of the leptin binding sites and design of a leptin antagonist.

J Biol Chem 2004 Sep 21;279(39):41038-46. Epub 2004 Jun 21.

Department of Medical Protein Research, Faculty of Medicine and Health Sciences, Flanders Interuniversity Institute for Biotechnology, VIB09, Ghent University, Albert Baertsoenkaai 3, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M404962200DOI Listing
September 2004

Phosphorylation by protein kinase CK2 modulates the activity of the ATP binding cassette A1 transporter.

J Biol Chem 2004 Sep 24;279(36):37779-88. Epub 2004 Jun 24.

Department of Biochemistry, Faculty of Medicine and Health Sciences, Ghent University, B-9000 Ghent, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M401821200DOI Listing
September 2004

Expression and activity of the nucleotide-binding domains of the human ABCA1 transporter.

Protein Expr Purif 2004 May;35(1):102-10

Department of Biochemistry, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pep.2003.12.015DOI Listing
May 2004

The ins and outs of leptin receptor activation.

FEBS Lett 2003 Jul;546(1):45-50

The Flanders Interuniversity Institute for Biotechnology, Department of Medical Protein Research (VIB9), Ghent University, Faculty of Medicine and Health Sciences, Baertsoenkaai 3, B-9000 Ghent, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0014-5793(03)00440-xDOI Listing
July 2003