Frank P Luyten

Frank P Luyten

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Frank P Luyten

Publications by authors named "Frank P Luyten"

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Neurofibromatosis type 1-related pseudarthrosis: Beyond the pseudarthrosis site.

Hum Mutat 2019 Oct 18;40(10):1760-1767. Epub 2019 Jun 18.

Department of Human Genetics, KU Leuven-University of Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1002/humu.23783DOI Listing
October 2019

Human Platelet Lysate Improves Bone Forming Potential of Human Progenitor Cells Expanded in Microcarrier-Based Dynamic Culture.

Stem Cells Transl Med 2019 Aug 30;8(8):810-821. Epub 2019 Apr 30.

Prometheus, Division of Skeletal Tissue Engineering, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1002/sctm.18-0216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6646698PMC
August 2019

Towards Self-Regulated Bioprocessing: A Compact Benchtop Bioreactor System for Monitored and Controlled 3D Cell and Tissue Culture.

Biotechnol J 2019 Jul 15;14(7):e1800545. Epub 2019 May 15.

Prometheus, Division of Skeletal Tissue Engineering, Katholieke Universiteit Leuven, Onderwijs & Navorsing 1, Herestraat 49, Box 813, 3000, Leuven, Belgium.

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http://dx.doi.org/10.1002/biot.201800545DOI Listing
July 2019

Quality of care for knee osteoarthritis in primary care: a patient's perspective.

Arthritis Care Res (Hoboken) 2019 Jul 19. Epub 2019 Jul 19.

Academic Centre for General Practice, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1002/acr.24034DOI Listing
July 2019

Rebound-associated vertebral fractures after stopping denosumab: Report of four cases.

Joint Bone Spine 2019 Jul 29. Epub 2019 Jul 29.

Gerontology & Geriatrics, Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), KU Leuven, Herestraat 49 box 7003, 3000 Leuven, Belgium; Department of Geriatric Medicine, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium; Centre for Metabolic Bone Diseases, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium.

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http://dx.doi.org/10.1016/j.jbspin.2019.07.010DOI Listing
July 2019

Reduction of BMP6-induced bone formation by calcium phosphate in wild-type compared with nude mice.

J Tissue Eng Regen Med 2019 May 27;13(5):846-856. Epub 2019 Mar 27.

Tissue Engineering Laboratory, Skeletal Biology and Engineering Research Center, Katholieke Universiteit Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1002/term.2837DOI Listing
May 2019

Gelatin microspheres releasing transforming growth factor drive in vitro chondrogenesis of human periosteum derived cells in micromass culture.

Acta Biomater 2019 May 21;90:287-299. Epub 2019 Mar 21.

Department of Materials Engineering, KU Leuven, Kasteelpark Arenberg 44, box 2450, 3001 Leuven, Belgium; Prometheus, Division of Skeletal Tissue Engineering, KU Leuven, Herestraat 49, box 813, 3000 Leuven, Belgium; Department of Imaging & Pathology, KU Leuven, Kapucijnenvoer 7 block a, box 7001, 3000 Leuven, Belgium. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S17427061193021
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http://dx.doi.org/10.1016/j.actbio.2019.03.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597958PMC
May 2019

Educational outreach visits to improve knee osteoarthritis management in primary care.

BMC Med Educ 2019 Mar 1;19(1):66. Epub 2019 Mar 1.

Academic Center for General Practice, KU Leuven, Kapucijnenvoer 33, J building, 3000, Leuven, Belgium.

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http://dx.doi.org/10.1186/s12909-019-1504-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397491PMC
March 2019

SMOC2 inhibits calcification of osteoprogenitor and endothelial cells.

PLoS One 2018 13;13(6):e0198104. Epub 2018 Jun 13.

Laboratory of Tissue Homeostasis and Disease, Skeletal Biology and Engineering Research Center, Department of Development and Regeneration, KU Leuven, Leuven, Belgium.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0198104PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5999237PMC
January 2019

Close to the bone - in search of the skeletal stem cell.

Nat Rev Rheumatol 2018 12;14(12):687-688

New Medicines, UCB Pharma, Slough, UK.

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http://www.nature.com/articles/s41584-018-0121-6
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http://dx.doi.org/10.1038/s41584-018-0121-6DOI Listing
December 2018

Bone regeneration strategies: Engineered scaffolds, bioactive molecules and stem cells current stage and future perspectives.

Biomaterials 2018 10 11;180:143-162. Epub 2018 Jul 11.

Grenoble Institute of Technology, Univ. Grenoble Alpes, 38000 Grenoble, France; CNRS, LMGP, 3 Parvis Louis Néel, 38031 Grenoble Cedex 01, France. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2018.07.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6710094PMC
October 2018

Deciphering the combined effect of bone morphogenetic protein 6 and calcium phosphate on bone formation capacity of periosteum derived cells-based tissue engineering constructs.

Acta Biomater 2018 10 26;80:97-107. Epub 2018 Sep 26.

Prometheus, Division of Skeletal Tissue Engineering, KU Leuven, Leuven, Belgium; Skeletal Biology and Engineering Research Center, Department of Development and Regeneration, KU Leuven, Leuven, Belgium. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S17427061183057
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http://dx.doi.org/10.1016/j.actbio.2018.09.046DOI Listing
October 2018

In Vitro Screening of Molecularly Engineered Polyethylene Glycol Hydrogels for Cartilage Tissue Engineering using Periosteum-Derived and ATDC5 Cells.

Int J Mol Sci 2018 Oct 26;19(11). Epub 2018 Oct 26.

Department of Materials Engineering, KU Leuven, Kasteelpark Arenberg 44, Box 2450, 3001 Leuven, Belgium.

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http://www.mdpi.com/1422-0067/19/11/3341
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http://dx.doi.org/10.3390/ijms19113341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274881PMC
October 2018

Towards secondary prevention of early knee osteoarthritis.

RMD Open 2018 13;4(2):e000468. Epub 2018 Aug 13.

Skeletal Biology & Engineering Research Center, Department of Development & Regeneration, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1136/rmdopen-2017-000468DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109947PMC
August 2018

From skeletal development to the creation of pluripotent stem cell-derived bone-forming progenitors.

Philos Trans R Soc Lond B Biol Sci 2018 07;373(1750)

Laboratory for Developmental and Stem Cell Biology (DSB), Skeletal Biology and Engineering Research Center (SBE), KU Leuven, Herestraat 49 Box 813, 3000 Leuven, Belgium

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http://dx.doi.org/10.1098/rstb.2017.0218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974441PMC
July 2018

Fine-tuning pro-angiogenic effects of cobalt for simultaneous enhancement of vascular endothelial growth factor secretion and implant neovascularization.

Acta Biomater 2018 05 4;72:447-460. Epub 2018 Apr 4.

Tissue Engineering Laboratory, Skeletal Biology and Engineering Research Center, KU Leuven, O&N 1, Herestraat 49, bus 813, 3000 Leuven, Belgium; Prometheus, Division of Skeletal Tissue Engineering, KU Leuven, O&N 1, Herestraat 49, bus 813, 3000 Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.actbio.2018.03.048DOI Listing
May 2018

Limb derived cells as a paradigm for engineering self-assembling skeletal tissues.

J Tissue Eng Regen Med 2018 03 17;12(3):794-807. Epub 2017 Sep 17.

Skeletal Biology and Engineering Research Center, Department of Development and Regeneration, Belgium.

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http://dx.doi.org/10.1002/term.2498DOI Listing
March 2018

Simultaneous three-dimensional visualization of mineralized and soft skeletal tissues by a novel microCT contrast agent with polyoxometalate structure.

Biomaterials 2018 03 22;159:1-12. Epub 2017 Dec 22.

Prometheus, Division of Skeletal Tissue Engineering, KU Leuven, Leuven, Belgium; Clinical and Experimental Endocrinology, Department of Clinical and Experimental Medicine, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1016/j.biomaterials.2017.12.016DOI Listing
March 2018

An Integrated Bioprocess for the Expansion and Chondrogenic Priming of Human Periosteum-Derived Progenitor Cells in Suspension Bioreactors.

Biotechnol J 2018 Feb 20;13(2). Epub 2017 Nov 20.

Prometheus Division of Skeletal Tissue Engineering, KU Leuven, O&N1 Herestraat 49, Leuven, Belgium.

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http://dx.doi.org/10.1002/biot.201700087DOI Listing
February 2018

Folic Acid Exposure Rescues Spina Bifida Aperta Phenotypes in Human Induced Pluripotent Stem Cell Model.

Sci Rep 2018 02 13;8(1):2942. Epub 2018 Feb 13.

Translational Cardiomyology Laboratory, Stem Cell Biology and Embryology Unit, Stem Cell Institute, Department of Development and Regeneration, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1038/s41598-018-21103-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811493PMC
February 2018

RGD-functionalized polyethylene glycol hydrogels support proliferation and in vitro chondrogenesis of human periosteum-derived cells.

J Biomed Mater Res A 2018 Jan 23;106(1):33-42. Epub 2017 Sep 23.

Department of Materials Engineering, KU Leuven, Kasteelpark Arenberg 44, Box 2450, Leuven, 3001, Belgium.

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http://dx.doi.org/10.1002/jbm.a.36208DOI Listing
January 2018

The Impact of Type 2 Diabetes on Bone Fracture Healing.

Front Endocrinol (Lausanne) 2018 24;9. Epub 2018 Jan 24.

Prometheus-Division of Skeletal Tissue Engineering Leuven, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.3389/fendo.2018.00006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5787540PMC
January 2018

Changes in gait characteristics of women with early and established medial knee osteoarthritis: Results from a 2-years longitudinal study.

Clin Biomech (Bristol, Avon) 2017 Dec 2;50:32-39. Epub 2017 Oct 2.

Department of Rehabilitation Sciences, Faculty of Kinesiology and Rehabilitation Sciences, KU Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.clinbiomech.2017.10.004DOI Listing
December 2017

Warning About the Use of Critical-Size Defects for the Translational Study of Bone Repair: Analysis of a Sheep Tibial Model.

Tissue Eng Part C Methods 2017 11 3;23(11):694-699. Epub 2017 Jul 3.

1 Department of Orthopaedic Surgery, University Hospitals KU Leuven , Leuven, Belgium .

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http://dx.doi.org/10.1089/ten.TEC.2017.0147DOI Listing
November 2017

Integrin-Linked Kinase Regulates Bone Formation by Controlling Cytoskeletal Organization and Modulating BMP and Wnt Signaling in Osteoprogenitors.

J Bone Miner Res 2017 Oct 30;32(10):2087-2102. Epub 2017 Jun 30.

Laboratory of Skeletal Cell Biology and Physiology (SCEBP), Skeletal Biology and Engineering Research Center (SBE), Department of Development and Regeneration, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1002/jbmr.3190DOI Listing
October 2017

Harnessing the Osteogenicity of In Vitro Stem Cell-Derived Mineralized Extracellular Matrix as 3D Biotemplate to Guide Bone Regeneration.

Tissue Eng Part A 2017 09 24;23(17-18):874-890. Epub 2017 Mar 24.

1 Tissue Engineering Laboratory, Skeletal Biology and Engineering Research Center , KU Leuven, Leuven, Belgium .

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http://dx.doi.org/10.1089/ten.tea.2016.0432DOI Listing
September 2017

Dynamic and static knee alignment at baseline predict structural abnormalities on MRI associated with medial compartment knee osteoarthritis after 2 years.

Gait Posture 2017 09 24;57:46-51. Epub 2017 May 24.

Department of Rehabilitation Sciences, Faculty of Kinesiology and Rehabilitation Sciences, KU Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.gaitpost.2017.05.024DOI Listing
September 2017

Do Psychosocial Factors Predict Muscle Strength, Pain, or Physical Performance in Patients With Knee Osteoarthritis?

J Clin Rheumatol 2017 Sep;23(6):308-316

From the *Department of Rehabilitation Sciences, Faculty of Kinesiology and Rehabilitation Sciences, KU Leuven, Leuven; †Department of Rehabilitation Sciences and Physiotherapy, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp; ‡Pain in Motion International Research Group; §Department of Rehabilitation Sciences and Physiotherapy, Ghent University, Ghent; ∥Division of Rheumatology, UZ-KU Leuven, Leuven; and ¶Departments of Physiotherapy, Physiology and Anatomy, Faculty of Physical Education & Physiotherapy, Vrije Universiteit Brussel, Brussels, Belgium.

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http://Insights.ovid.com/crossref?an=00124743-201709000-0000
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http://dx.doi.org/10.1097/RHU.0000000000000560DOI Listing
September 2017

Initiating human articular chondrocyte re-differentiation in a 3D system after 2D expansion.

J Mater Sci Mater Med 2017 Sep 5;28(10):156. Epub 2017 Sep 5.

Department of Materials Engineering, KU Leuven, Kasteelpark Arenberg 44, P.O. box 2450, Leuven, 3001, Belgium.

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http://dx.doi.org/10.1007/s10856-017-5968-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585276PMC
September 2017

Healing of a Large Long-Bone Defect through Serum-Free In Vitro Priming of Human Periosteum-Derived Cells.

Stem Cell Reports 2017 03 9;8(3):758-772. Epub 2017 Feb 9.

Tissue Engineering Laboratory, Skeletal Biology and Engineering Research Center, KU Leuven, O&N 1, Herestraat 49, Box 813 13, 3000 Leuven, Belgium; Prometheus, Division of Skeletal Tissue Engineering, KU Leuven, O&N 1, Herestraat 49, Box 813 13, 3000 Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2017.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355567PMC
March 2017

Large-Scale Mesenchymal Stem/Stromal Cell Expansion: A Visualization Tool for Bioprocess Comparison.

Tissue Eng Part B Rev 2016 12 19;22(6):485-498. Epub 2016 Aug 19.

2 Prometheus, Division of Skeletal Tissue Engineering , KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1089/ten.TEB.2016.0111DOI Listing
December 2016

Varus thrust in women with early medial knee osteoarthritis and its relation with the external knee adduction moment.

Clin Biomech (Bristol, Avon) 2016 11 8;39:109-114. Epub 2016 Oct 8.

Department of Rehabilitation Sciences, Faculty of Kinesiology and Rehabilitation Sciences, KU Leuven, Belgium. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S02680033163015
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http://dx.doi.org/10.1016/j.clinbiomech.2016.10.006DOI Listing
November 2016

Large-scale progenitor cell expansion for multiple donors in a monitored hollow fibre bioreactor.

Cytotherapy 2016 09 12;18(9):1219-33. Epub 2016 Jul 12.

Prometheus-Division of Skeletal Tissue Engineering, KU Leuven, Belgium; Division Animal and Human Health Engineering, KU Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.jcyt.2016.05.013DOI Listing
September 2016

Systemic Inflammation Affects Human Osteocyte-Specific Protein and Cytokine Expression.

Calcif Tissue Int 2016 06 18;98(6):596-608. Epub 2016 Feb 18.

Department of Clinical Chemistry, VU University Medical Center, MOVE Research Institute Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s00223-016-0116-8DOI Listing
June 2016

Biomechanical and neuromuscular adaptations during the landing phase of a stepping-down task in patients with early or established knee osteoarthritis.

Knee 2016 Jun 26;23(3):367-75. Epub 2016 Feb 26.

Musculoskeletal Rehabilitation Research Group, Department of Rehabilitation Sciences, Faculty of Kinesiology and Rehabilitation Sciences, KU Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.knee.2016.02.002DOI Listing
June 2016

Multifactorial Optimization of Contrast-Enhanced Nanofocus Computed Tomography for Quantitative Analysis of Neo-Tissue Formation in Tissue Engineering Constructs.

PLoS One 2015 15;10(6):e0130227. Epub 2015 Jun 15.

Prometheus, Division of Skeletal Tissue Engineering, KU Leuven, Leuven, Belgium; Biomechanics Research Unit, Université de Liege, Liège, Belgium; Department of Mechanical Engineering, Biomechanics Section, KU Leuven, Heverlee, Belgium.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0130227PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467978PMC
May 2016

Bioreactor-Based Online Recovery of Human Progenitor Cells with Uncompromised Regenerative Potential: A Bone Tissue Engineering Perspective.

PLoS One 2015 27;10(8):e0136875. Epub 2015 Aug 27.

Prometheus, Division of Skeletal Tissue Engineering, KU Leuven, Leuven, Belgium; Department of Development and Regeneration, Skeletal Biology and Engineering Research Center, KU Leuven, Leuven, Belgium.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0136875PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552169PMC
May 2016

Combinatorial Analysis of Growth Factors Reveals the Contribution of Bone Morphogenetic Proteins to Chondrogenic Differentiation of Human Periosteal Cells.

Tissue Eng Part C Methods 2016 05;22(5):473-86

1 Tissue Engineering Laboratory, Skeletal Biology and Engineering Research Center , Katholieke Universiteit Leuven, Leuven, Belgium .

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http://dx.doi.org/10.1089/ten.TEC.2015.0436DOI Listing
May 2016

Serum of patients with active rheumatoid arthritis inhibits differentiation of osteochondrogenic precursor cells.

Connect Tissue Res 2016 05 6;57(3):226-35. Epub 2016 Apr 6.

b Skeletal Biology and Engineering Research Center , KU Leuven, Leuven , Belgium.

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http://dx.doi.org/10.3109/03008207.2016.1146714DOI Listing
May 2016

Early BMP, Wnt and Ca(2+)/PKC pathway activation predicts the bone forming capacity of periosteal cells in combination with calcium phosphates.

Biomaterials 2016 Apr 29;86:106-18. Epub 2016 Jan 29.

Tissue Engineering Laboratory, Skeletal Biology and Engineering Research Center, KU Leuven, O&N 1, Herestraat 49, Bus 813, 3000 Leuven, Belgium; Prometheus, Division of Skeletal Tissue Engineering, KU Leuven, O&N 1, Herestraat 49, Bus 813, 3000 Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2016.01.059DOI Listing
April 2016

HIF-1α Promotes Glutamine-Mediated Redox Homeostasis and Glycogen-Dependent Bioenergetics to Support Postimplantation Bone Cell Survival.

Cell Metab 2016 Feb;23(2):265-79

Laboratory of Clinical and Experimental Endocrinology, Department of Clinical and Experimental Medicine, KU Leuven, 3000 Leuven, Belgium; Prometheus, Division of Skeletal Tissue Engineering, KU Leuven, 3000 Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.01.002DOI Listing
February 2016

Changes in proprioceptive weighting during quiet standing in women with early and established knee osteoarthritis compared to healthy controls.

Gait Posture 2016 Feb 14;44:184-8. Epub 2015 Dec 14.

Department of Rehabilitation Sciences, Faculty of Kinesiology and Rehabilitation Sciences, KU Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.gaitpost.2015.12.010DOI Listing
February 2016

A homeostatic function of CXCR2 signalling in articular cartilage.

Ann Rheum Dis 2015 Dec 18;74(12):2207-15. Epub 2014 Aug 18.

Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.

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http://dx.doi.org/10.1136/annrheumdis-2014-205546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4680121PMC
December 2015

Mechanical loading reduces inflammation-induced human osteocyte-to-osteoclast communication.

Calcif Tissue Int 2015 Aug 13;97(2):169-78. Epub 2015 May 13.

Department of Oral Cell Biology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam, MOVE Research Institute Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s00223-015-9999-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491366PMC
August 2015

Orphan G-protein coupled receptor 22 (Gpr22) regulates cilia length and structure in the zebrafish Kupffer's vesicle.

PLoS One 2014 21;9(10):e110484. Epub 2014 Oct 21.

Department of Development and Regeneration, Laboratory for Developmental and Stem Cell Biology, Skeletal Biology and Engineering Research Centre, University of Leuven, Leuven, Belgium; Department of Biochemistry and Molecular Biology, Medical University, Lublin, Poland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0110484PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4204907PMC
June 2015

Quantitative Validation of the Presto Blue Metabolic Assay for Online Monitoring of Cell Proliferation in a 3D Perfusion Bioreactor System.

Tissue Eng Part C Methods 2015 Jun 31;21(6):519-29. Epub 2015 Mar 31.

1Prometheus, Division of Skeletal Tissue Engineering, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1089/ten.TEC.2014.0255DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4442584PMC
June 2015

Uncovering the periosteum for skeletal regeneration: the stem cell that lies beneath.

Bone 2015 Jan 2;70:10-8. Epub 2014 Sep 2.

Skeletal Biology and Engineering Research Center, KU Leuven, O&N 1 Herestraat 49 bus 813, 3000 Leuven, Belgium; Prometheus, Division of Skeletal Tissue Engineering, KU Leuven, O&N 1 Herestraat 49 bus 813, 3000 Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.bone.2014.08.007DOI Listing
January 2015

Targets, models and challenges in osteoarthritis research.

Dis Model Mech 2015 Jan;8(1):17-30

Laboratory of Tissue Homeostasis and Disease, Skeletal Biology and Engineering Research Center, KU Leuven, 3000 Leuven, Belgium. Division of Rheumatology, University Hospitals Leuven, KU Leuven, 3000 Leuven, Belgium.

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http://dx.doi.org/10.1242/dmm.016881DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4283647PMC
January 2015

Spatial optimization in perfusion bioreactors improves bone tissue-engineered construct quality attributes.

Biotechnol Bioeng 2014 Dec 14;111(12):2560-70. Epub 2014 Jul 14.

Prometheus, Division of Skeletal Tissue Engineering, KU Leuven, Onderwijs en Navorsing 1 (+8), Herestraat 49-PB813, B-3000, Leuven, Belgium; Skeletal Biology and Engineering Research Center, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1002/bit.25303DOI Listing
December 2014

In vivo ectopic bone formation by devitalized mineralized stem cell carriers produced under mineralizing culture condition.

Biores Open Access 2014 Dec;3(6):265-77

Prometheus, Division of Skeletal Tissue Engineering, KU Leuven , Leuven, Belgium . ; Department of Materials Engineering, KU Leuven , Heverlee, Belgium .

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http://dx.doi.org/10.1089/biores.2014.0050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245878PMC
December 2014

Smoc2 modulates embryonic myelopoiesis during zebrafish development.

Dev Dyn 2014 Nov 30;243(11):1375-90. Epub 2014 Jul 30.

Laboratory for Developmental and Stem Cell Biology, Skeletal Biology and Engineering Research Center, Department of Development and Regeneration, KU Leuven - University of Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1002/dvdy.24164DOI Listing
November 2014

Secreted frizzled related proteins inhibit fibrosis in vitro but appear redundant in vivo.

Fibrogenesis Tissue Repair 2014 2;7:14. Epub 2014 Oct 2.

Department of Development and Regeneration, Laboratory of Tissue Homeostasis and Disease, Skeletal Biology and Engineering Research Center, KU Leuven, Leuven, Belgium ; Division of Rheumatology, University Hospitals Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1186/1755-1536-7-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196208PMC
October 2014

Weak associations between structural changes on MRI and symptoms, function and muscle strength in relation to knee osteoarthritis.

Knee Surg Sports Traumatol Arthrosc 2014 Sep 2;22(9):2013-25. Epub 2013 Feb 2.

Department of Rehabilitation Sciences, Faculty of Kinesiology and Rehabilitation Sciences, KU Leuven, Tervuursevest 101, 3001, Heverlee, Belgium,

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http://dx.doi.org/10.1007/s00167-013-2434-yDOI Listing
September 2014

Skeletal tissue regeneration: where can hydrogels play a role?

Int Orthop 2014 Sep 27;38(9):1861-76. Epub 2014 Jun 27.

Prometheus, Division of Skeletal Tissue Engineering, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1007/s00264-014-2402-2DOI Listing
September 2014

Expansion of murine periosteal progenitor cells with fibroblast growth factor 2 reveals an intrinsic endochondral ossification program mediated by bone morphogenetic protein 2.

Stem Cells 2014 Sep;32(9):2407-18

Laboratory of Clinical and Experimental Endocrinology, Department of Clinical and Experimental Medicine, KU Leuven, Leuven, Belgium; Prometheus, Division of Skeletal Tissue Engineering, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1002/stem.1783DOI Listing
September 2014

Three-dimensional characterization of tissue-engineered constructs by contrast-enhanced nanofocus computed tomography.

Tissue Eng Part C Methods 2014 Mar 19;20(3):177-87. Epub 2013 Oct 19.

1 Prometheus, Division of Skeletal Tissue Engineering , KU Leuven, Leuven, Belgium .

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http://dx.doi.org/10.1089/ten.TEC.2013.0041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936499PMC
March 2014

Humanized culture of periosteal progenitors in allogeneic serum enhances osteogenic differentiation and in vivo bone formation.

Stem Cells Transl Med 2014 Feb 27;3(2):218-28. Epub 2013 Dec 27.

Laboratory for Developmental and Stem Cell Biology, Skeletal Biology and Engineering Research Center, Prometheus, Division of Skeletal Tissue Engineering, and Department and Laboratory of Intensive Care Medicine, KU Leuven, Leuven, Belgium; Institute of Orthopaedics and Musculoskeletal Science, Division of Surgery & Interventional Science, University College London, The Royal National Orthopaedic Hospital, Stanmore, Middlesex, United Kingdom.

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http://dx.doi.org/10.5966/sctm.2012-0137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3925047PMC
February 2014

Sox9 reprogrammed dermal fibroblasts undergo hypertrophic differentiation in vitro and trigger endochondral ossification in vivo.

Cell Reprogram 2014 Feb;16(1):29-39

1 Laboratory for Developmental and Stem Cell Biology (DSB) , Skeletal Biology and Engineering Research Center (SBE), KU Leuven, 3000, Leuven, Belgium .

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http://dx.doi.org/10.1089/cell.2013.0060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920914PMC
February 2014

Proprioceptive accuracy in women with early and established knee osteoarthritis and its relation to functional ability, postural control, and muscle strength.

Clin Rheumatol 2013 Sep 15;32(9):1365-74. Epub 2013 May 15.

Department of Rehabilitation Sciences, Faculty of Kinesiology and Rehabilitation Sciences, KU Leuven, Tervuursevest 101, 3001, Heverlee, Belgium.

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http://dx.doi.org/10.1007/s10067-013-2285-4DOI Listing
September 2013

Osteoarthritis, a disease bridging development and regeneration.

Bonekey Rep 2012 1;1:136. Epub 2012 Aug 1.

Laboratory for Skeletal Development and Joint Disorders, Department of Development and Regeneration, KU Leuven , Leuven, Belgium . ; Division of Rheumatology, University Hospitals Leuven , Leuven, Belgium .

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http://dx.doi.org/10.1038/bonekey.2012.136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3727791PMC
August 2013

Process quality engineering for bioreactor-driven manufacturing of tissue-engineered constructs for bone regeneration.

Tissue Eng Part C Methods 2013 Aug 20;19(8):596-609. Epub 2013 Feb 20.

Laboratory for Skeletal Development and Joint Disorders, Katholieke Universiteit Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1089/ten.TEC.2012.0526DOI Listing
August 2013

Mapping calcium phosphate activated gene networks as a strategy for targeted osteoinduction of human progenitors.

Biomaterials 2013 Jun 26;34(19):4612-21. Epub 2013 Mar 26.

Skeletal Biology and Engineering Research Center, Department of Development and Regeneration, KU Leuven, O&N1, Herestraat 49, PB 813, 3000 Leuven, Belgium.

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http://dx.doi.org/10.1016/j.biomaterials.2013.03.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4037407PMC
June 2013

Quantification of lung fibrosis and emphysema in mice using automated micro-computed tomography.

PLoS One 2012 13;7(8):e43123. Epub 2012 Aug 13.

Laboratory for Skeletal Development and Joint Disorders, Department of Development and Regeneration, KU Leuven, Leuven, Belgium. Ellen. elanghe@u leuven.be

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0043123PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3418271PMC
May 2013

Gait characteristics and lower limb muscle strength in women with early and established knee osteoarthritis.

Clin Biomech (Bristol, Avon) 2013 Jan 16;28(1):40-7. Epub 2012 Nov 16.

Department of Rehabilitation Sciences, Faculty of Kinesiology and Rehabilitation Sciences, KU Leuven, Tervuursevest 101, Heverlee, Belgium.

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http://dx.doi.org/10.1016/j.clinbiomech.2012.10.007DOI Listing
January 2013

Genetic deletion of low-density lipoprotein receptor-related protein 5 increases cartilage degradation in instability-induced osteoarthritis.

Rheumatology (Oxford) 2012 Nov 31;51(11):1973-8. Epub 2012 Jul 31.

Division of Rheumatology, University Hospitals Leuven, Herestraat 49, B3000 Leuven, Belgium.

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http://dx.doi.org/10.1093/rheumatology/kes178DOI Listing
November 2012

Engineering vascularized bone: osteogenic and proangiogenic potential of murine periosteal cells.

Stem Cells 2012 Nov;30(11):2460-71

Laboratory of Clinical and Experimental Endocrinology, Division of Skeletal Tissue Engineering, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1002/stem.1210DOI Listing
November 2012

Structure of NPP1, an ectonucleotide pyrophosphatase/phosphodiesterase involved in tissue calcification.

Structure 2012 Nov 4;20(11):1948-59. Epub 2012 Oct 4.

Laboratory of Biosignaling and Therapeutics, Department of Cellular and Molecular Medicine, University of Leuven, 3000 Leuven, Belgium.

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https://linkinghub.elsevier.com/retrieve/pii/S09692126120033
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http://dx.doi.org/10.1016/j.str.2012.09.001DOI Listing
November 2012

Tissue engineering approaches for osteoarthritis.

Bone 2012 Aug 17;51(2):289-96. Epub 2011 Oct 17.

Division of Rheumatology, Department of Musculoskeletal Sciences, Katholieke Universiteit Leuven, Herestraat 49, B-3000 Leuven, Belgium.

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https://linkinghub.elsevier.com/retrieve/pii/S87563282110128
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http://dx.doi.org/10.1016/j.bone.2011.10.007DOI Listing
August 2012

Characterized chondrocyte implantation in the patellofemoral joint: an up to 4-year follow-up of a prospective cohort of 38 patients.

Am J Sports Med 2012 Aug 11;40(8):1799-807. Epub 2012 Jul 11.

University Hospitals Leuven, Department of Development and Regeneration, Division of Orthopedics and Traumatology, Weligerveld 1, Pellenberg, Leuven, 3212 Belgium.

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http://ajs.sagepub.com/content/40/8/1799.full.pdf
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http://ajs.sagepub.com/lookup/doi/10.1177/0363546512452712
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http://dx.doi.org/10.1177/0363546512452712DOI Listing
August 2012

A semi-autonomous model of endochondral ossification for developmental tissue engineering.

Tissue Eng Part A 2012 Jul 16;18(13-14):1334-43. Epub 2012 Apr 16.

Laboratory for Skeletal Development and Joint Disorders, Katholieke Universiteit Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1089/ten.TEA.2011.0602DOI Listing
July 2012

Critical illness-related bone loss is associated with osteoclastic and angiogenic abnormalities.

J Bone Miner Res 2012 Jul;27(7):1541-52

Department and Laboratory of Intensive Care Medicine, Katholieke Universiteit Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1002/jbmr.1612DOI Listing
July 2012

Validation of a PicoGreen-based DNA quantification integrated in an RNA extraction method for two-dimensional and three-dimensional cell cultures.

Tissue Eng Part C Methods 2012 Jun 26;18(6):444-52. Epub 2012 Jan 26.

Laboratory for Skeletal Development and Joint Disorders, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1089/ten.TEC.2011.0304DOI Listing
June 2012

An N-terminal G11A mutation in HOXD13 causes synpolydactyly and interferes with Gli3R function during limb pre-patterning.

Hum Mol Genet 2012 Jun 27;21(11):2464-75. Epub 2012 Feb 27.

Laboratory of Skeletal Development and Joint Disorders, University of Leuven, Herestraat 49, O&N1 Box 813, 3000 Leuven, Belgium.

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http://dx.doi.org/10.1093/hmg/dds060DOI Listing
June 2012

Ectopic bone formation by 3D porous calcium phosphate-Ti6Al4V hybrids produced by perfusion electrodeposition.

Biomaterials 2012 Jun 28;33(16):4044-58. Epub 2012 Feb 28.

Laboratory for Skeletal Development and Joint Disorders, KU Leuven, O&N 1, Herestraat 49, Bus 813, 3000 Leuven, Belgium.

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http://dx.doi.org/10.1016/j.biomaterials.2012.02.026DOI Listing
June 2012

Blocking p38 signalling inhibits chondrogenesis in vitro but not ankylosis in a model of ankylosing spondylitis in vivo.

Ann Rheum Dis 2012 May 25;71(5):722-8. Epub 2011 Nov 25.

Laboratory for Skeletal Development and Joint Disorders, Division of Rheumatology, KULeuven, Leuven, Belgium.

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http://dx.doi.org/10.1136/annrheumdis-2011-200377DOI Listing
May 2012

Mechanisms of ectopic bone formation by human osteoprogenitor cells on CaP biomaterial carriers.

Biomaterials 2012 Apr 24;33(11):3127-42. Epub 2012 Jan 24.

Laboratory for Skeletal Development and Joint Disorders, Katholieke Universiteit Leuven, O&N 1, Herestraat 49, Bus 813, 3000 Leuven, Belgium.

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http://dx.doi.org/10.1016/j.biomaterials.2012.01.015DOI Listing
April 2012

Biological aspects of early osteoarthritis.

Knee Surg Sports Traumatol Arthrosc 2012 Mar 19;20(3):407-22. Epub 2011 Oct 19.

Experimental Orthopaedics and Osteoarthritis Research, Saarland University, Kirrbergerstrasse, Building 37, 66421, Homburg, Germany.

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http://dx.doi.org/10.1007/s00167-011-1705-8DOI Listing
March 2012

Definition and classification of early osteoarthritis of the knee.

Knee Surg Sports Traumatol Arthrosc 2012 Mar 8;20(3):401-6. Epub 2011 Nov 8.

Division of Rheumatology, Laboratory for Skeletal Development and Joint Disorders, Katholieke Universiteit Leuven, O&N 1, Herestraat 49, Bus 813, 3000, Leuven, Belgium.

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http://link.springer.com/10.1007/s00167-011-1743-2
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http://dx.doi.org/10.1007/s00167-011-1743-2DOI Listing
March 2012

Inhibition of inflammation but not ankylosis by glucocorticoids in mice: further evidence for the entheseal stress hypothesis.

Arthritis Res Ther 2012 Mar 12;14(2):R59. Epub 2012 Mar 12.

Laboratory for Skeletal Development and Joint Disorders, Department of Development and Regeneration, KU Leuven, Herestraat 49, Leuven, 3000, Belgium.

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http://dx.doi.org/10.1186/ar3772DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446425PMC
March 2012

Multi-level factorial analysis of Ca2+/Pi supplementation as bio-instructive media for in vitro biomimetic engineering of three-dimensional osteogenic hybrids.

Tissue Eng Part C Methods 2012 Feb 2;18(2):90-103. Epub 2011 Nov 2.

Laboratory for Skeletal Development and Joint Disorders, Katholieke Universiteit Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1089/ten.TEC.2011.0248DOI Listing
February 2012

Tight regulation of wingless-type signaling in the articular cartilage - subchondral bone biomechanical unit: transcriptomics in Frzb-knockout mice.

Arthritis Res Ther 2012 Jan 20;14(1):R16. Epub 2012 Jan 20.

Laboratory for Skeletal Development and Joint Disorders, Department of Development and Regeneration, KU Leuven, Belgium.

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http://arthritis-research.biomedcentral.com/articles/10.1186
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http://dx.doi.org/10.1186/ar3695DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3392806PMC
January 2012

Characterization and optimization of cell seeding in scaffolds by factorial design: quality by design approach for skeletal tissue engineering.

Tissue Eng Part C Methods 2011 Dec 6;17(12):1211-21. Epub 2011 Sep 6.

Laboratory for Skeletal Development and Joint Disorders, Katholieke Universiteit Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1089/ten.tec.2011.0092DOI Listing
December 2011

Five-year outcome of characterized chondrocyte implantation versus microfracture for symptomatic cartilage defects of the knee: early treatment matters.

Am J Sports Med 2011 Dec 9;39(12):2566-74. Epub 2011 Sep 9.

Division of Orthopedics and Traumatology, Department of Musculoskeletal Sciences, University Hospitals, Catholic University of Leuven, Belgium.

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http://dx.doi.org/10.1177/0363546511422220DOI Listing
December 2011

Noggin null allele mice exhibit a microform of holoprosencephaly.

Hum Mol Genet 2011 Oct 5;20(20):4005-15. Epub 2011 Aug 5.

Department of Craniofacial Development, King's College, London, UK.

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http://dx.doi.org/10.1093/hmg/ddr329DOI Listing
October 2011

Enhancement of osteogenic gene expression for the differentiation of human periosteal derived cells.

Stem Cell Res 2011 Sep 10;7(2):137-44. Epub 2011 May 10.

Laboratory for Skeletal Development and Joint Disorders, Katholieke Universiteit Leuven, O&N 1, Herestraat 49, bus 813, 3000 Leuven, Belgium.

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http://dx.doi.org/10.1016/j.scr.2011.04.003DOI Listing
September 2011

Functional effects of susceptibility genes in osteoarthritis.

Discov Med 2011 Aug;12(63):129-39

Department of Musculoskeletal Sciences, K.U. Leuven, Leuven, Belgium.

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August 2011

The combined bone forming capacity of human periosteal derived cells and calcium phosphates.

Biomaterials 2011 Jul 21;32(19):4393-405. Epub 2011 Mar 21.

Laboratory for Skeletal Development and Joint Disorders, Katholieke Universiteit Leuven, Belgium.

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http://dx.doi.org/10.1016/j.biomaterials.2011.02.047DOI Listing
July 2011

Modularity in developmental biology and artificial organs: a missing concept in tissue engineering.

Artif Organs 2011 Jun 14;35(6):656-62. Epub 2011 Feb 14.

Department of Biochemistry and Molecular Biology IV, Veterinary Faculty, Complutense University of Madrid, Madrid, Spain.

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http://dx.doi.org/10.1111/j.1525-1594.2010.01135.xDOI Listing
June 2011

Destructive dural ectasia of dorsal and lumbar spine with cauda equina syndrome in a patient with ankylosing spondylitis.

Open Rheumatol J 2010 Aug 26;4:31-4. Epub 2010 Aug 26.

Division of Rheumatology, University Hospitals Leuven, Herestraat 49, B-3000, Leuven, Belgium.

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http://dx.doi.org/10.2174/1874312901004010031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040454PMC
August 2010