Frank Maldarelli

Frank Maldarelli

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Frank Maldarelli

Publications by authors named "Frank Maldarelli"

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Benzodiazepines Drive Alteration of Chromatin at the Integrated HIV-1 LTR.

Viruses 2020 Feb 9;12(2). Epub 2020 Feb 9.

Department of Biological Sciences, University of the Sciences, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.3390/v12020191DOI Listing
February 2020

Principles Governing Establishment versus Collapse of HIV-1 Cellular Spread.

Cell Host Microbe 2019 12 21;26(6):748-763.e20. Epub 2019 Nov 21.

Immunology Section, Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2019.10.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6948011PMC
December 2019

Corrigendum: A 28-Year History of HIV-1 Drug Resistance and Transmission in Washington, DC.

Front Microbiol 2019;10:2590. Epub 2019 Nov 12.

Computational Biology Institute, Milken Institute School of Public Health, George Washington University, Washington, DC, United States.

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http://dx.doi.org/10.3389/fmicb.2019.02590DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861842PMC
November 2019

8-Day Inpatient Directly Observed Therapy for ART Failure: A Tool For Preventing Unnecessary ART Changes and Optimizing Adherence Support.

Clin Infect Dis 2019 Jul 11. Epub 2019 Jul 11.

National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), Bethesda, Maryland, USA.

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http://dx.doi.org/10.1093/cid/ciz590DOI Listing
July 2019

Low-level alternative tRNA priming of reverse transcription of HIV-1 and SIV in vivo.

Retrovirology 2019 04 4;16(1):11. Epub 2019 Apr 4.

AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, MD, 21702, USA.

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http://dx.doi.org/10.1186/s12977-019-0473-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450007PMC
April 2019

A 28-Year History of HIV-1 Drug Resistance and Transmission in Washington, DC.

Front Microbiol 2019 8;10:369. Epub 2019 Mar 8.

Computational Biology Institute, Milken Institute School of Public Health, George Washington University, Washington, DC, United States.

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http://dx.doi.org/10.3389/fmicb.2019.00369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418020PMC
March 2019

Quantification of HIV DNA Using Droplet Digital PCR Techniques.

Curr Protoc Microbiol 2018 11 25;51(1):e62. Epub 2018 Sep 25.

HIV Dynamics and Replication Program, NCI, NIH, Frederick, Maryland.

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http://dx.doi.org/10.1002/cpmc.62DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209535PMC
November 2018

The role of integration and clonal expansion in HIV infection: live long and prosper.

Retrovirology 2018 10 23;15(1):71. Epub 2018 Oct 23.

HIV Dynamics and Replication Program, NCI, NIH, Frederick, MD, 21702, USA.

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https://retrovirology.biomedcentral.com/articles/10.1186/s12
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http://dx.doi.org/10.1186/s12977-018-0448-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199739PMC
October 2018

Ongoing HIV Replication During ART Reconsidered.

Open Forum Infect Dis 2017 19;4(3):ofx173. Epub 2017 Sep 19.

Department of Molecular Biology and Microbiology, Tufts University, Boston, Massachusetts.

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https://academic.oup.com/ofid/article/doi/10.1093/ofid/ofx17
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http://dx.doi.org/10.1093/ofid/ofx173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172598PMC
September 2017

Pomalidomide for Symptomatic Kaposi's Sarcoma in People With and Without HIV Infection: A Phase I/II Study.

J Clin Oncol 2016 12 31;34(34):4125-4131. Epub 2016 Oct 31.

Mark N. Polizzotto, Thomas S. Uldrick, Kathleen M. Wyvill, Karen Aleman, Cody J. Peer, Frank Maldarelli, Priscila H. Goncalves, William D. Figg, Seth M. Steinberg, and Robert Yarchoan, National Cancer Institute; Margaret Bevans, National Institutes of Health; Irini Sereti, National Institute of Allergy and Infectious Diseases, Bethesda, MD; Denise Whitby and Vickie Marshall, Frederick National Cancer Laboratory for Cancer Research, Frederick, MD; and Vikram Khetani and Jerome B. Zeldis, Celgene Corporation, Summit, NJ.

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http://dx.doi.org/10.1200/JCO.2016.69.3812DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477825PMC
December 2016

Ultrasensitive single-genome sequencing: accurate, targeted, next generation sequencing of HIV-1 RNA.

Retrovirology 2016 Dec 20;13(1):87. Epub 2016 Dec 20.

Department of Molecular Biology and Microbiology, Tufts University, Boston, MA, USA.

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http://dx.doi.org/10.1186/s12977-016-0321-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5175307PMC
December 2016

APOBEC3 proteins can copackage and comutate HIV-1 genomes.

Nucleic Acids Res 2016 09 20;44(16):7848-65. Epub 2016 Jul 20.

Viral Mutation Section, HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA

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http://dx.doi.org/10.1093/nar/gkw653DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027510PMC
September 2016

Characteristics and Outcome of Patients Diagnosed With HIV at Older Age.

Medicine (Baltimore) 2016 Jan;95(1):e2327

From the Unit of Clinical Immunology, Allergy, and Neve -Or AIDS center and the Department of Medicine B, Kaplan Medical Center, Rehovot, affiliated with Hebrew University-Hadassah Medical School, Jerusalem, Israel (IA, KMG, DE, SRB, ZMS); National Cancer Institute, Frederick, Maryland (FM, ZG); Central Virology Laboratory, Ministry of Health, Ramat-Gan (OM); and School of Public Health, Tel-Aviv University, Tel-Aviv, Israel (ZG).

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http://erj.ersjournals.com/content/27/6/1223.full.pdf
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/MD.0000000000002327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4706254PMC
January 2016

HIV-infected cells are frequently clonally expanded after prolonged antiretroviral therapy: implications for HIV persistence.

Authors:
Frank Maldarelli

J Virus Erad 2015 Oct 1;1(4):237-44. Epub 2015 Oct 1.

Clinical Retrovirology Section , Center for Cancer Research , National Cancer Research , Bethesda , MD , USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946654PMC
October 2015

HIV-1 infection leads to increased transcription of human endogenous retrovirus HERV-K (HML-2) proviruses in vivo but not to increased virion production.

J Virol 2014 Oct 23;88(19):11108-20. Epub 2014 Jul 23.

Graduate Program in Molecular Microbiology, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, Massachusetts, USA

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http://jvi.asm.org/cgi/doi/10.1128/JVI.01623-14
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http://dx.doi.org/10.1128/JVI.01623-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4178833PMC
October 2014

PAPNC, a novel method to calculate nucleotide diversity from large scale next generation sequencing data.

J Virol Methods 2014 Jul 26;203:73-80. Epub 2014 Mar 26.

Department of Molecular Biology and Microbiology, Tufts University, Boston, MA, United States.

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http://dx.doi.org/10.1016/j.jviromet.2014.03.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104926PMC
July 2014

Single-copy quantification of HIV-1 in clinical samples.

Methods Mol Biol 2014 ;1087:251-60

HIV Drug Resistance Program, Frederick National Laboratory for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA.

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http://dx.doi.org/10.1007/978-1-62703-670-2_20DOI Listing
May 2014

Rational development of radiopharmaceuticals for HIV-1.

Nucl Med Biol 2014 Apr 17;41(4):299-308. Epub 2014 Jan 17.

National Institutes of Health.

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http://dx.doi.org/10.1016/j.nucmedbio.2014.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954989PMC
April 2014

Activation of HIV-1 from latent infection via synergy of RUNX1 inhibitor Ro5-3335 and SAHA.

PLoS Pathog 2014 Mar 20;10(3):e1003997. Epub 2014 Mar 20.

Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1003997DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3961356PMC
March 2014

Lack of detectable HIV-1 molecular evolution during suppressive antiretroviral therapy.

PLoS Pathog 2014 Mar 20;10(3):e1004010. Epub 2014 Mar 20.

HIV-1 Drug Resistance Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, United States of America.

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https://dx.plos.org/10.1371/journal.ppat.1004010
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http://dx.doi.org/10.1371/journal.ppat.1004010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3961343PMC
March 2014

Limited nucleotide changes in the Rev response element (RRE) during HIV-1 infection alter overall Rev-RRE activity and Rev multimerization.

J Virol 2013 Oct 7;87(20):11173-86. Epub 2013 Aug 7.

Department of Microbiology, Immunology and Cancer Biology and The Myles H. Thaler Center for AIDS and Human Retrovirus Research, University of Virginia, Charlottesville, Virginia, USA.

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http://dx.doi.org/10.1128/JVI.01392-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3807272PMC
October 2013

Connection subdomain mutations in HIV-1 subtype-C treatment-experienced patients enhance NRTI and NNRTI drug resistance.

Virology 2013 Jan 13;435(2):433-41. Epub 2012 Oct 13.

Viral Mutation Section, HIV Drug Resistance Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1016/j.virol.2012.09.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3534945PMC
January 2013

Estimate of effective recombination rate and average selection coefficient for HIV in chronic infection.

Proc Natl Acad Sci U S A 2011 Apr 21;108(14):5661-6. Epub 2011 Mar 21.

Department of Physics and Astronomy, Tufts University, Medford, MA 02155, USA.

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http://dx.doi.org/10.1073/pnas.1102036108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078368PMC
April 2011

Clinical management of HIV drug resistance.

Viruses 2011 04 14;3(4):347-78. Epub 2011 Apr 14.

HIV Drug Resistance Program, NCI, NIH, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.3390/v3040347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185705PMC
April 2011

CD4 and CD8 T cell immune activation during chronic HIV infection: roles of homeostasis, HIV, type I IFN, and IL-7.

J Immunol 2011 Feb 21;186(4):2106-16. Epub 2011 Jan 21.

Clinical and Molecular Retrovirology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.4049/jimmunol.1002000DOI Listing
February 2011

Genetic diversity of simian immunodeficiency virus encoding HIV-1 reverse transcriptase persists in macaques despite antiretroviral therapy.

J Virol 2011 Jan 17;85(2):1067-76. Epub 2010 Nov 17.

HIV Drug Resistance Program, National Cancer Institute at Frederick, 1050 Boyles Street, Building 535, Room 109, Frederick, MD 21702-1201, USA.

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http://dx.doi.org/10.1128/JVI.01701-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3019993PMC
January 2011

Targeting viral reservoirs: ability of antiretroviral therapy to stop viral replication.

Authors:
Frank Maldarelli

Curr Opin HIV AIDS 2011 Jan;6(1):49-56

HIV Drug Resistance Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1097/COH.0b013e32834134eaDOI Listing
January 2011

XMRV: a new virus in prostate cancer?

Cancer Res 2010 Dec 21;70(24):10028-33. Epub 2010 Oct 21.

HIV Drug Resistance Program, National Cancer Institute, Frederick, MD 21702, USA.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-10-2837DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005136PMC
December 2010

Characterization of the meiosis-specific recombinase Dmc1 of pneumocystis.

J Infect Dis 2010 Dec 4;202(12):1920-9. Epub 2010 Nov 4.

Critical Care Medicine Department, National Institutes of Health (NIH) Clinical Center, National Institutes of Allergy and Infectious Diseases, USA.

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http://dx.doi.org/10.1086/657414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058675PMC
December 2010

RT-SHIV subpopulation dynamics in infected macaques during anti-HIV therapy.

Retrovirology 2009 Nov 4;6:101. Epub 2009 Nov 4.

Advanced Biomedical Computing Center, SAIC Frederick, Inc, National Cancer Institute at Frederick, Frederick, MD, USA.

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http://dx.doi.org/10.1186/1742-4690-6-101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2776578PMC
November 2009

Subtype-specific differences in the human immunodeficiency virus type 1 reverse transcriptase connection subdomain of CRF01_AE are associated with higher levels of resistance to 3'-azido-3'-deoxythymidine.

J Virol 2009 Sep 24;83(17):8502-13. Epub 2009 Jun 24.

Viral Mutation Section, Host-Virus Interaction Branch, HIV Drug Resistance Program, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA.

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http://dx.doi.org/10.1128/JVI.00859-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2738196PMC
September 2009

Efavirenz induces CYP2B6-mediated hydroxylation of bupropion in healthy subjects.

J Acquir Immune Defic Syndr 2008 Dec;49(5):513-9

Office of Clinical Pharmacology, US Food and Drug Administration, Silver Spring, MD 20993, USA.

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http://dx.doi.org/10.1097/QAI.0b013e318183a425DOI Listing
December 2008

Iatrogenic Cushing syndrome after epidural triamcinolone injections in an HIV type 1-infected patient receiving therapy with ritonavir-lopinavir.

Clin Infect Dis 2008 Dec;47(12):e97-9

Clinical Parasitology Unit and Helminth Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1086/593314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2941349PMC
December 2008

Variation in the major surface glycoprotein genes in Pneumocystis jirovecii.

J Infect Dis 2008 Sep;198(5):741-9

Critical Care Medicine Department, National Institutes of Health Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1086/590433DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2561252PMC
September 2008

Low-level viremia persists for at least 7 years in patients on suppressive antiretroviral therapy.

Proc Natl Acad Sci U S A 2008 Mar 10;105(10):3879-84. Epub 2008 Mar 10.

HIV Drug Resistance Program, National Cancer Institute, National Institutes of Health, Frederick, MD 21702-1201, USA.

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http://dx.doi.org/10.1073/pnas.0800050105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2268833PMC
March 2008

Frequent polymorphism at drug resistance sites in HIV-1 protease and reverse transcriptase.

AIDS 2008 Feb;22(4):497-501

HIV Drug Resistance Program, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702-1201, USA.

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http://dx.doi.org/10.1097/QAD.0b013e3282f29478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2921824PMC
February 2008

Mutations in the connection domain of HIV-1 reverse transcriptase increase 3'-azido-3'-deoxythymidine resistance.

Proc Natl Acad Sci U S A 2007 Jan 19;104(1):317-22. Epub 2006 Dec 19.

Viral Mutation Section and Host-Virus Interaction Unit, HIV Drug Resistance Program, and Data Management Services, Inc., National Cancer Institute, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1073/pnas.0609642104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1765458PMC
January 2007

Tenofovir disoproxil fumarate and an optimized background regimen of antiretroviral agents as salvage therapy for pediatric HIV infection.

Pediatrics 2005 Dec 15;116(6):e846-54. Epub 2005 Nov 15.

HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1542/peds.2005-0975DOI Listing
December 2005

Mechanism for nucleoside analog-mediated abrogation of HIV-1 replication: balance between RNase H activity and nucleotide excision.

Proc Natl Acad Sci U S A 2005 Feb 31;102(6):2093-8. Epub 2005 Jan 31.

Viral Mutation Section, HIV Drug Resistance Program, National Cancer Institute, Frederick, MD 21702, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0409823102
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http://dx.doi.org/10.1073/pnas.0409823102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC548555PMC
February 2005

Prion Diseases: Update on Mad Cow Disease, Variant Creutzfeldt-Jakob Disease, and the Transmissible Spongiform Encephalopathies.

Curr Infect Dis Rep 2004 Aug;6(4):305-315

NCI, National Institutes of Health, Building 10, Room 12S245, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1007/s11908-004-0053-yDOI Listing
August 2004

A proof-of-concept study of short-cycle intermittent antiretroviral therapy with a once-daily regimen of didanosine, lamivudine, and efavirenz for the treatment of chronic HIV infection.

J Infect Dis 2004 Jun 10;189(11):1974-82. Epub 2004 May 10.

Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, United States Department of Health and Human Services, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1086/386344DOI Listing
June 2004

Nonrandom HIV-1 infection and double infection via direct and cell-mediated pathways.

Proc Natl Acad Sci U S A 2004 Jan 5;101(2):632-7. Epub 2004 Jan 5.

HIV Drug Resistance Program and Data Management Services, National Cancer Institute-Frederick, National Institutes of Health, MD 21702, USA.

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http://dx.doi.org/10.1073/pnas.0307636100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC327199PMC
January 2004