Publications by authors named "Frank M Longo"

72Publications

Restoration of motor learning in a mouse model of Rett syndrome following long-term treatment with a novel small-molecule activator of TrkB.

Dis Model Mech 2020 Nov 27;13(11). Epub 2020 Nov 27.

Department of Neurosciences, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106-4975, USA

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November 2020

Oral Administration of the p75 Neurotrophin Receptor Modulator, LM11A-31, Improves Erectile Function in a Mouse Model of Cavernous Nerve Injury.

J Sex Med 2021 Jan 24;18(1):17-28. Epub 2020 Nov 24.

National Research Center for Sexual Medicine and Department of Urology, Inha University School of Medicine, Incheon, Republic of Korea. Electronic address:

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January 2021

Small molecule modulation of the p75 neurotrophin receptor inhibits multiple amyloid beta-induced tau pathologies.

Sci Rep 2020 11 23;10(1):20322. Epub 2020 Nov 23.

Department of Neurology and Neurological Sciences, Stanford University School of Medicine, 300 Pasteur Drive, Room H3160, Stanford, CA, 94305, USA.

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November 2020

Small molecule modulation of the p75 neurotrophin receptor suppresses age- and genotype-associated neurodegeneration in HIV gp120 transgenic mice.

Exp Neurol 2021 Jan 29;335:113489. Epub 2020 Sep 29.

Department of Neurology, University of North Carolina, Chapel Hill, NC 27599, United States of America; Neurobiology Curriculum, University of North Carolina, Chapel Hill, NC 27599, United States of America. Electronic address:

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January 2021

Small-molecule modulation of the p75 neurotrophin receptor inhibits a wide range of tau molecular pathologies and their sequelae in P301S tauopathy mice.

Acta Neuropathol Commun 2020 09 5;8(1):156. Epub 2020 Sep 5.

Department of Neurology and Neurological Sciences, Stanford University School of Medicine, 300 Pasteur Drive, Room H3160, Stanford, CA, 94305, USA.

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September 2020

Partial Activation of TrkB Receptors Corrects Interneuronal Calcium Channel Dysfunction and Reduces Epileptogenic Activity in Neocortex following Injury.

Cereb Cortex 2020 Jul;30(9):5180-5189

Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305-5122, USA.

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July 2020

Nerve Growth Factor Pathobiology During the Progression of Alzheimer's Disease.

Front Neurosci 2019 1;13:533. Epub 2019 Jul 1.

Department of Neurology and Department of Psychiatry, Geriatric Research Education and Clinical Center, VA Pittsburgh Healthcare System, University of Pittsburgh, Pittsburgh, PA, United States.

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July 2019

Reduced cognitive deficits after FLASH irradiation of whole mouse brain are associated with less hippocampal dendritic spine loss and neuroinflammation.

Radiother Oncol 2019 10 25;139:4-10. Epub 2019 Jun 25.

Department of Radiation Oncology, Stanford University School of Medicine, United States; Stanford Cancer Institute, Stanford University School of Medicine, United States. Electronic address:

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October 2019

Loss of Adaptive Myelination Contributes to Methotrexate Chemotherapy-Related Cognitive Impairment.

Neuron 2019 07 20;103(2):250-265.e8. Epub 2019 May 20.

Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA 94305, USA; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA; Department of Pathology, Stanford University, Stanford, CA 94305, USA; Department of Pediatrics, Stanford University, Stanford, CA 94305, USA; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA 94305, USA. Electronic address:

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July 2019

Early life stress disrupts intestinal homeostasis via NGF-TrkA signaling.

Nat Commun 2019 04 15;10(1):1745. Epub 2019 Apr 15.

Institute of Brain and Gut Axis (IBAG), Centre of Clinical Research for Chinese Medicine, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR, China.

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April 2019

Modulation of the p75 neurotrophin receptor suppresses age-related basal forebrain cholinergic neuron degeneration.

Sci Rep 2019 03 27;9(1):5273. Epub 2019 Mar 27.

Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, 94305, USA.

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March 2019

Unsolicited Patient Complaints Identify Physicians with Evidence of Neurocognitive Disorders.

Am J Geriatr Psychiatry 2018 09 8;26(9):927-936. Epub 2018 May 8.

Center for Patient and Professional Advocacy, Vanderbilt University Medical Center, Nashville, TN; Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN.

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September 2018

Partial TrkB receptor activation suppresses cortical epileptogenesis through actions on parvalbumin interneurons.

Neurobiol Dis 2018 05 2;113:45-58. Epub 2018 Feb 2.

Department of Neurology and Neurological Sciences, Stanford University School of Medicine, United States. Electronic address:

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May 2018

Glial scars are permeable to the neurotoxic environment of chronic stroke infarcts.

Neurobiol Dis 2018 04 10;112:63-78. Epub 2018 Jan 10.

Department of Immunobiology, University of Arizona, Tucson, AZ 85719, USA; Department of Neurology, University of Arizona, Tucson, AZ 85719, USA; Arizona Center on Aging, University of Arizona, Tucson, AZ 85719, USA. Electronic address:

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April 2018

A small-molecule TrkB ligand restores hippocampal synaptic plasticity and object location memory in Rett syndrome mice.

Dis Model Mech 2017 07;10(7):837-845

Department of Neurobiology, Civitan International Research Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA

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July 2017

Neurotrophin Receptor Signaling as a Therapeutic Target for Huntington's Disease.

CNS Neurol Disord Drug Targets 2017 ;16(3):291-302

Department of Neurology, San Francisco VAMC and UCSF, MS127, San Francisco, CA 94121. United States.

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May 2018

The Neurotrophic Factor Receptor p75 in the Rat Dorsolateral Striatum Drives Excessive Alcohol Drinking.

J Neurosci 2016 09 28;36(39):10116-27. Epub 2016 Sep 28.

Department of Neurology, University of California, San Francisco, San Francisco, California 94143,

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September 2016

A small molecule TrkB/TrkC neurotrophin receptor co-activator with distinctive effects on neuronal survival and process outgrowth.

Neuropharmacology 2016 11 19;110(Pt A):343-361. Epub 2016 Jun 19.

Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address:

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November 2016

Novel p75 neurotrophin receptor ligand stabilizes neuronal calcium, preserves mitochondrial movement and protects against HIV associated neuropathogenesis.

Exp Neurol 2016 Jan 28;275 Pt 1:182-98. Epub 2015 Sep 28.

Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, United States.

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January 2016

B-lymphocyte-mediated delayed cognitive impairment following stroke.

J Neurosci 2015 Feb;35(5):2133-45

Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305, Department of Neurosurgery, Stanford University School of Medicine, Stanford, California 94305

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February 2015

Amelioration of cisplatin-induced experimental peripheral neuropathy by a small molecule targeting p75 NTR.

Neurotoxicology 2014 Dec 30;45:81-90. Epub 2014 Sep 30.

Department of Anatomy and Cell Biology, The Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA; Leo Jenkins Cancer Center, The Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA. Electronic address:

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December 2014

Role of CSPG receptor LAR phosphatase in restricting axon regeneration after CNS injury.

Neurobiol Dis 2015 Jan 8;73:36-48. Epub 2014 Sep 8.

Shriners Hospitals Pediatric Research Center, Temple University School of Medicine, Philadelphia, PA 19140, USA; Department of Anatomy and Cell Biology, Temple University School of Medicine, Philadelphia, PA 19140, USA. Electronic address:

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January 2015

A small molecule p75NTR ligand, LM11A-31, reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models with mid- to late-stage disease progression.

PLoS One 2014 25;9(8):e102136. Epub 2014 Aug 25.

Department of Neurology and Neurological Sciences, Stanford University, Stanford, California, United States of America; Department of Neurology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.

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May 2015

Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice.

Nat Med 2014 Jun 4;20(6):659-63. Epub 2014 May 4.

1] Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA. [2] Neuroscience Graduate Program, Stanford University School of Medicine, Stanford, California, USA. [3] Center for Tissue Regeneration, Repair and Restoration, VA Palo Alto Health Care System, Palo Alto, California, USA.

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June 2014

A small molecule TrkB ligand reduces motor impairment and neuropathology in R6/2 and BACHD mouse models of Huntington's disease.

J Neurosci 2013 Nov;33(48):18712-27

Department of Neurology and Neurological Sciences and Behavioral and Functional Neuroscience Laboratory, Institute for Neuro-Innovation and Translational Neurosciences, Stanford University School of Medicine, Stanford, California 94305, Department of Psychiatry, Weill Cornell Medical College, New York, New York 10021, and Department of Neurology and Laboratory for Computational Neurochemistry and Drug Discovery, Department of Veterans Affairs Medical Center and Department of Neurology, University of California, San Francisco, San Francisco, California 94121.

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November 2013

Small-molecule modulation of neurotrophin receptors: a strategy for the treatment of neurological disease.

Nat Rev Drug Discov 2013 Jul;12(7):507-25

Department of Neurology and Neurological Sciences, Stanford University, 300 Pasteur Drive, Stanford, California 94305, USA.

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July 2013

A small molecule p75(NTR) ligand protects neurogenesis after traumatic brain injury.

Stem Cells 2013 Nov;31(11):2561-74

Department of Neurology, Department of Veterans Affairs Medical Center, San Francisco and University of California, San Francisco, California, USA.

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November 2013

Delayed administration of a small molecule tropomyosin-related kinase B ligand promotes recovery after hypoxic-ischemic stroke.

Stroke 2012 Jul 24;43(7):1918-24. Epub 2012 Apr 24.

Department of Neurology and Neurological Sciences, Stanford University School of Medicine, 1201 Welch Road, MSLS Building, P209, Stanford, CA 94305-5489, USA.

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July 2012

Suppression of immunodeficiency virus-associated neural damage by the p75 neurotrophin receptor ligand, LM11A-31, in an in vitro feline model.

J Neuroimmune Pharmacol 2012 Jun 10;7(2):388-400. Epub 2011 Dec 10.

Department of Neurology, University of North Carolina, CB #7025, 115 Mason Farm Road, Chapel Hill, NC 27599, USA

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June 2012

Leukocyte common antigen-related phosphatase is a functional receptor for chondroitin sulfate proteoglycan axon growth inhibitors.

J Neurosci 2011 Oct;31(40):14051-66

Department of Neurology and Neuroscience Graduate Program, University of Texas Southwestern Medical Center, Dallas, Texas 75390-8813, USA.

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October 2011

The p75 neurotrophin receptor is expressed by adult mouse dentate progenitor cells and regulates neuronal and non-neuronal cell genesis.

BMC Neurosci 2010 Oct 20;11:136. Epub 2010 Oct 20.

Department of Neurology, UCSF/VAMC, San Francisco, CA 94121, USA.

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October 2010

Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents.

J Clin Invest 2010 May 19;120(5):1774-85. Epub 2010 Apr 19.

Department of Neurology and Laboratory for Computational Neurochemistry and Drug Discovery, UCSF, San Francisco, California, USA.

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May 2010

Signaling through Rho GTPase pathway as viable drug target.

Curr Med Chem 2009 ;16(11):1355-65

Department of Anatomy, East Carolina University, The Brody School of Medicine, 600 Moye Boulevard, Greenville, NC 27834, USA.

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June 2009

A common motif targets huntingtin and the androgen receptor to the proteasome.

J Biol Chem 2008 Aug 27;283(35):23950-5. Epub 2008 Jun 27.

Departments of Neurology and Cellular and Molecular Pharmacology, University of California-San Francisco, 600 16th Street, San Francisco, CA 94143, USA.

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August 2008

Anti-cancer drug induced neurotoxicity and identification of Rho pathway signaling modulators as potential neuroprotectants.

Neurotoxicology 2008 Jul 26;29(4):605-12. Epub 2008 Apr 26.

Department of Anatomy and Cell Biology, The Brody School of Medicine at East Carolina University, Greenville, NC 27834, United States.

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July 2008

Small molecule modulation of p75 neurotrophin receptor functions.

CNS Neurol Disord Drug Targets 2008 Feb;7(1):63-70

Dept. of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.

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February 2008

Small molecule neurotrophin receptor ligands: novel strategies for targeting Alzheimer's disease mechanisms.

Curr Alzheimer Res 2007 Dec;4(5):503-6

Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA 94305, USA.

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December 2007

E-cadherin promotes retinal ganglion cell neurite outgrowth in a protein tyrosine phosphatase-mu-dependent manner.

Mol Cell Neurosci 2007 Mar 2;34(3):481-92. Epub 2007 Feb 2.

Department of Molecular Biology and Microbiology, Case Western Reserve University, School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106-4960, USA.

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March 2007

LAR protein tyrosine phosphatase receptor associates with TrkB and modulates neurotrophic signaling pathways.

J Neurobiol 2006 Nov;66(13):1420-36

Department of Neurology, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina 27599, USA.

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November 2006

Modulation of p75-dependent motor neuron death by a small non-peptidyl mimetic of the neurotrophin loop 1 domain.

Eur J Neurosci 2006 Sep;24(6):1575-80

Departamento de Neurobiología Celulary Molecular, Instituto de Investigaciones Biológicas Clemente Estable, Montevideo 11600, Uruguay.

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September 2006

Downregulation of the LAR protein tyrosine phosphatase receptor is associated with increased dentate gyrus neurogenesis and an increased number of granule cell layer neurons.

Mol Cell Neurosci 2006 Apr 20;31(4):723-38. Epub 2006 Feb 20.

UNC School of Medicine, Department of Neurology CB7025, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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April 2006

Small molecule approaches for promoting neurogenesis.

Curr Alzheimer Res 2006 Feb;3(1):5-10

Department of Neurology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.

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February 2006

Neurotrophin receptor-based strategies for Alzheimer's disease.

Curr Alzheimer Res 2005 Apr;2(2):167-9

Department of Neurology, University of North Carolina, Chapel Hill, University of California, San Francisco, USA.

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April 2005

Neuroprotective strategies in Alzheimer's disease.

NeuroRx 2004 Jan;1(1):117-27

Department of Neurology, University of North Carolina, Chapel Hill, North Carolina 27599, USA.

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January 2004

Neurotrophin-based strategies for neuroprotection.

J Alzheimers Dis 2004 Dec;6(6 Suppl):S13-7

Department of Neurology, University of North Carolina, Chapel Hill, NC 27599, USA.

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December 2004

Alzheimer's therapeutics: neurotrophin domain small molecule mimetics.

J Mol Neurosci 2003 ;20(3):323-6

Department of Neurology, VAMC/UC San Francisco, CA 94121, USA.

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December 2003

Alzheimer's therapeutics: neurotrophin small molecule mimetics.

J Mol Neurosci 2002 Aug-Oct;19(1-2):107-11

Department of Neurology VAMC/UC San Francisco, CA, USA.

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January 2003