Frank M LaFerla

Frank M LaFerla

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Frank M LaFerla

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Author Correction: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.

Authors:
Brian W Kunkle Benjamin Grenier-Boley Rebecca Sims Joshua C Bis Vincent Damotte Adam C Naj Anne Boland Maria Vronskaya Sven J van der Lee Alexandre Amlie-Wolf Céline Bellenguez Aura Frizatti Vincent Chouraki Eden R Martin Kristel Sleegers Nandini Badarinarayan Johanna Jakobsdottir Kara L Hamilton-Nelson Sonia Moreno-Grau Robert Olaso Rachel Raybould Yuning Chen Amanda B Kuzma Mikko Hiltunen Taniesha Morgan Shahzad Ahmad Badri N Vardarajan Jacques Epelbaum Per Hoffmann Merce Boada Gary W Beecham Jean-Guillaume Garnier Denise Harold Annette L Fitzpatrick Otto Valladares Marie-Laure Moutet Amy Gerrish Albert V Smith Liming Qu Delphine Bacq Nicola Denning Xueqiu Jian Yi Zhao Maria Del Zompo Nick C Fox Seung-Hoan Choi Ignacio Mateo Joseph T Hughes Hieab H Adams John Malamon Florentino Sanchez-Garcia Yogen Patel Jennifer A Brody Beth A Dombroski Maria Candida Deniz Naranjo Makrina Daniilidou Gudny Eiriksdottir Shubhabrata Mukherjee David Wallon James Uphill Thor Aspelund Laura B Cantwell Fabienne Garzia Daniela Galimberti Edith Hofer Mariusz Butkiewicz Bertrand Fin Elio Scarpini Chloe Sarnowski Will S Bush Stéphane Meslage Johannes Kornhuber Charles C White Yuenjoo Song Robert C Barber Sebastiaan Engelborghs Sabrina Sordon Dina Voijnovic Perrie M Adams Rik Vandenberghe Manuel Mayhaus L Adrienne Cupples Marilyn S Albert Peter P De Deyn Wei Gu Jayanadra J Himali Duane Beekly Alessio Squassina Annette M Hartmann Adelina Orellana Deborah Blacker Eloy Rodriguez-Rodriguez Simon Lovestone Melissa E Garcia Rachelle S Doody Carmen Munoz-Fernadez Rebecca Sussams Honghuang Lin Thomas J Fairchild Yolanda A Benito Clive Holmes Hata Karamujić-Čomić Matthew P Frosch Hakan Thonberg Wolfgang Maier Gennady Roshchupkin Bernardino Ghetti Vilmantas Giedraitis Amit Kawalia Shuo Li Ryan M Huebinger Lena Kilander Susanne Moebus Isabel Hernández M Ilyas Kamboh RoseMarie Brundin James Turton Qiong Yang Mindy J Katz Letizia Concari Jenny Lord Alexa S Beiser C Dirk Keene Seppo Helisalmi Iwona Kloszewska Walter A Kukull Anne Maria Koivisto Aoibhinn Lynch Lluís Tarraga Eric B Larson Annakaisa Haapasalo Brian Lawlor Thomas H Mosley Richard B Lipton Vincenzo Solfrizzi Michael Gill W T Longstreth Thomas J Montine Vincenza Frisardi Monica Diez-Fairen Fernando Rivadeneira Ronald C Petersen Vincent Deramecourt Ignacio Alvarez Francesca Salani Antonio Ciaramella Eric Boerwinkle Eric M Reiman Nathalie Fievet Jerome I Rotter Joan S Reisch Olivier Hanon Chiara Cupidi A G Andre Uitterlinden Donald R Royall Carole Dufouil Raffaele Giovanni Maletta Itziar de Rojas Mary Sano Alexis Brice Roberta Cecchetti Peter St George-Hyslop Karen Ritchie Magda Tsolaki Debby W Tsuang Bruno Dubois David Craig Chuang-Kuo Wu Hilkka Soininen Despoina Avramidou Roger L Albin Laura Fratiglioni Antonia Germanou Liana G Apostolova Lina Keller Maria Koutroumani Steven E Arnold Francesco Panza Olymbia Gkatzima Sanjay Asthana Didier Hannequin Patrice Whitehead Craig S Atwood Paolo Caffarra Harald Hampel Inés Quintela Ángel Carracedo Lars Lannfelt David C Rubinsztein Lisa L Barnes Florence Pasquier Lutz Frölich Sandra Barral Bernadette McGuinness Thomas G Beach Janet A Johnston James T Becker Peter Passmore Eileen H Bigio Jonathan M Schott Thomas D Bird Jason D Warren Bradley F Boeve Michelle K Lupton James D Bowen Petra Proitsi Adam Boxer John F Powell James R Burke John S K Kauwe Jeffrey M Burns Michelangelo Mancuso Joseph D Buxbaum Ubaldo Bonuccelli Nigel J Cairns Andrew McQuillin Chuanhai Cao Gill Livingston Chris S Carlson Nicholas J Bass Cynthia M Carlsson John Hardy Regina M Carney Jose Bras Minerva M Carrasquillo Rita Guerreiro Mariet Allen Helena C Chui Elizabeth Fisher Carlo Masullo Elizabeth A Crocco Charles DeCarli Gina Bisceglio Malcolm Dick Li Ma Ranjan Duara Neill R Graff-Radford Denis A Evans Angela Hodges Kelley M Faber Martin Scherer Kenneth B Fallon Matthias Riemenschneider David W Fardo Reinhard Heun Martin R Farlow Heike Kölsch Steven Ferris Markus Leber Tatiana M Foroud Isabella Heuser Douglas R Galasko Ina Giegling Marla Gearing Michael Hüll Daniel H Geschwind John R Gilbert John Morris Robert C Green Kevin Mayo John H Growdon Thomas Feulner Ronald L Hamilton Lindy E Harrell Dmitriy Drichel Lawrence S Honig Thomas D Cushion Matthew J Huentelman Paul Hollingworth Christine M Hulette Bradley T Hyman Rachel Marshall Gail P Jarvik Alun Meggy Erin Abner Georgina E Menzies Lee-Way Jin Ganna Leonenko Luis M Real Gyungah R Jun Clinton T Baldwin Detelina Grozeva Anna Karydas Giancarlo Russo Jeffrey A Kaye Ronald Kim Frank Jessen Neil W Kowall Bruno Vellas Joel H Kramer Emma Vardy Frank M LaFerla Karl-Heinz Jöckel James J Lah Martin Dichgans James B Leverenz David Mann Allan I Levey Stuart Pickering-Brown Andrew P Lieberman Norman Klopp Kathryn L Lunetta H-Erich Wichmann Constantine G Lyketsos Kevin Morgan Daniel C Marson Kristelle Brown Frank Martiniuk Christopher Medway Deborah C Mash Markus M Nöthen Eliezer Masliah Nigel M Hooper Wayne C McCormick Antonio Daniele Susan M McCurry Anthony Bayer Andrew N McDavid John Gallacher Ann C McKee Hendrik van den Bussche Marsel Mesulam Carol Brayne Bruce L Miller Steffi Riedel-Heller Carol A Miller Joshua W Miller Ammar Al-Chalabi John C Morris Christopher E Shaw Amanda J Myers Jens Wiltfang Sid O'Bryant John M Olichney Victoria Alvarez Joseph E Parisi Andrew B Singleton Henry L Paulson John Collinge William R Perry Simon Mead Elaine Peskind David H Cribbs Martin Rossor Aimee Pierce Natalie S Ryan Wayne W Poon Benedetta Nacmias Huntington Potter Sandro Sorbi Joseph F Quinn Eleonora Sacchinelli Ashok Raj Gianfranco Spalletta Murray Raskind Carlo Caltagirone Paola Bossù Maria Donata Orfei Barry Reisberg Robert Clarke Christiane Reitz A David Smith John M Ringman Donald Warden Erik D Roberson Gordon Wilcock Ekaterina Rogaeva Amalia Cecilia Bruni Howard J Rosen Maura Gallo Roger N Rosenberg Yoav Ben-Shlomo Mark A Sager Patrizia Mecocci Andrew J Saykin Pau Pastor Michael L Cuccaro Jeffery M Vance Julie A Schneider Lori S Schneider Susan Slifer William W Seeley Amanda G Smith Joshua A Sonnen Salvatore Spina Robert A Stern Russell H Swerdlow Mitchell Tang Rudolph E Tanzi John Q Trojanowski Juan C Troncoso Vivianna M Van Deerlin Linda J Van Eldik Harry V Vinters Jean Paul Vonsattel Sandra Weintraub Kathleen A Welsh-Bohmer Kirk C Wilhelmsen Jennifer Williamson Thomas S Wingo Randall L Woltjer Clinton B Wright Chang-En Yu Lei Yu Yasaman Saba Alberto Pilotto Maria J Bullido Oliver Peters Paul K Crane David Bennett Paola Bosco Eliecer Coto Virginia Boccardi Phil L De Jager Alberto Lleo Nick Warner Oscar L Lopez Martin Ingelsson Panagiotis Deloukas Carlos Cruchaga Caroline Graff Rhian Gwilliam Myriam Fornage Alison M Goate Pascual Sanchez-Juan Patrick G Kehoe Najaf Amin Nilifur Ertekin-Taner Claudine Berr Stéphanie Debette Seth Love Lenore J Launer Steven G Younkin Jean-Francois Dartigues Chris Corcoran M Arfan Ikram Dennis W Dickson Gael Nicolas Dominique Campion JoAnn Tschanz Helena Schmidt Hakon Hakonarson Jordi Clarimon Ron Munger Reinhold Schmidt Lindsay A Farrer Christine Van Broeckhoven Michael C O'Donovan Anita L DeStefano Lesley Jones Jonathan L Haines Jean-Francois Deleuze Michael J Owen Vilmundur Gudnason Richard Mayeux Valentina Escott-Price Bruce M Psaty Alfredo Ramirez Li-San Wang Agustin Ruiz Cornelia M van Duijn Peter A Holmans Sudha Seshadri Julie Williams Phillippe Amouyel Gerard D Schellenberg Jean-Charles Lambert Margaret A Pericak-Vance

Nat Genet 2019 Aug 15. Epub 2019 Aug 15.

John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.

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http://dx.doi.org/10.1038/s41588-019-0495-7DOI Listing
August 2019

Past to Future: What Animal Models Have Taught Us About Alzheimer's Disease.

J Alzheimers Dis 2018 ;64(s1):S365-S378

Institute for Memory Impairments andNeurological Disorders, University of California, Irvine, CA, USA.

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http://dx.doi.org/10.3233/JAD-179917DOI Listing
June 2019

Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.

Authors:
Brian W Kunkle Benjamin Grenier-Boley Rebecca Sims Joshua C Bis Vincent Damotte Adam C Naj Anne Boland Maria Vronskaya Sven J van der Lee Alexandre Amlie-Wolf Céline Bellenguez Aura Frizatti Vincent Chouraki Eden R Martin Kristel Sleegers Nandini Badarinarayan Johanna Jakobsdottir Kara L Hamilton-Nelson Sonia Moreno-Grau Robert Olaso Rachel Raybould Yuning Chen Amanda B Kuzma Mikko Hiltunen Taniesha Morgan Shahzad Ahmad Badri N Vardarajan Jacques Epelbaum Per Hoffmann Merce Boada Gary W Beecham Jean-Guillaume Garnier Denise Harold Annette L Fitzpatrick Otto Valladares Marie-Laure Moutet Amy Gerrish Albert V Smith Liming Qu Delphine Bacq Nicola Denning Xueqiu Jian Yi Zhao Maria Del Zompo Nick C Fox Seung-Hoan Choi Ignacio Mateo Joseph T Hughes Hieab H Adams John Malamon Florentino Sanchez-Garcia Yogen Patel Jennifer A Brody Beth A Dombroski Maria Candida Deniz Naranjo Makrina Daniilidou Gudny Eiriksdottir Shubhabrata Mukherjee David Wallon James Uphill Thor Aspelund Laura B Cantwell Fabienne Garzia Daniela Galimberti Edith Hofer Mariusz Butkiewicz Bertrand Fin Elio Scarpini Chloe Sarnowski Will S Bush Stéphane Meslage Johannes Kornhuber Charles C White Yuenjoo Song Robert C Barber Sebastiaan Engelborghs Sabrina Sordon Dina Voijnovic Perrie M Adams Rik Vandenberghe Manuel Mayhaus L Adrienne Cupples Marilyn S Albert Peter P De Deyn Wei Gu Jayanadra J Himali Duane Beekly Alessio Squassina Annette M Hartmann Adelina Orellana Deborah Blacker Eloy Rodriguez-Rodriguez Simon Lovestone Melissa E Garcia Rachelle S Doody Carmen Munoz-Fernadez Rebecca Sussams Honghuang Lin Thomas J Fairchild Yolanda A Benito Clive Holmes Hata Karamujić-Čomić Matthew P Frosch Hakan Thonberg Wolfgang Maier Gennady Roshchupkin Bernardino Ghetti Vilmantas Giedraitis Amit Kawalia Shuo Li Ryan M Huebinger Lena Kilander Susanne Moebus Isabel Hernández M Ilyas Kamboh RoseMarie Brundin James Turton Qiong Yang Mindy J Katz Letizia Concari Jenny Lord Alexa S Beiser C Dirk Keene Seppo Helisalmi Iwona Kloszewska Walter A Kukull Anne Maria Koivisto Aoibhinn Lynch Lluís Tarraga Eric B Larson Annakaisa Haapasalo Brian Lawlor Thomas H Mosley Richard B Lipton Vincenzo Solfrizzi Michael Gill W T Longstreth Thomas J Montine Vincenza Frisardi Monica Diez-Fairen Fernando Rivadeneira Ronald C Petersen Vincent Deramecourt Ignacio Alvarez Francesca Salani Antonio Ciaramella Eric Boerwinkle Eric M Reiman Nathalie Fievet Jerome I Rotter Joan S Reisch Olivier Hanon Chiara Cupidi A G Andre Uitterlinden Donald R Royall Carole Dufouil Raffaele Giovanni Maletta Itziar de Rojas Mary Sano Alexis Brice Roberta Cecchetti Peter St George-Hyslop Karen Ritchie Magda Tsolaki Debby W Tsuang Bruno Dubois David Craig Chuang-Kuo Wu Hilkka Soininen Despoina Avramidou Roger L Albin Laura Fratiglioni Antonia Germanou Liana G Apostolova Lina Keller Maria Koutroumani Steven E Arnold Francesco Panza Olymbia Gkatzima Sanjay Asthana Didier Hannequin Patrice Whitehead Craig S Atwood Paolo Caffarra Harald Hampel Inés Quintela Ángel Carracedo Lars Lannfelt David C Rubinsztein Lisa L Barnes Florence Pasquier Lutz Frölich Sandra Barral Bernadette McGuinness Thomas G Beach Janet A Johnston James T Becker Peter Passmore Eileen H Bigio Jonathan M Schott Thomas D Bird Jason D Warren Bradley F Boeve Michelle K Lupton James D Bowen Petra Proitsi Adam Boxer John F Powell James R Burke John S K Kauwe Jeffrey M Burns Michelangelo Mancuso Joseph D Buxbaum Ubaldo Bonuccelli Nigel J Cairns Andrew McQuillin Chuanhai Cao Gill Livingston Chris S Carlson Nicholas J Bass Cynthia M Carlsson John Hardy Regina M Carney Jose Bras Minerva M Carrasquillo Rita Guerreiro Mariet Allen Helena C Chui Elizabeth Fisher Carlo Masullo Elizabeth A Crocco Charles DeCarli Gina Bisceglio Malcolm Dick Li Ma Ranjan Duara Neill R Graff-Radford Denis A Evans Angela Hodges Kelley M Faber Martin Scherer Kenneth B Fallon Matthias Riemenschneider David W Fardo Reinhard Heun Martin R Farlow Heike Kölsch Steven Ferris Markus Leber Tatiana M Foroud Isabella Heuser Douglas R Galasko Ina Giegling Marla Gearing Michael Hüll Daniel H Geschwind John R Gilbert John Morris Robert C Green Kevin Mayo John H Growdon Thomas Feulner Ronald L Hamilton Lindy E Harrell Dmitriy Drichel Lawrence S Honig Thomas D Cushion Matthew J Huentelman Paul Hollingworth Christine M Hulette Bradley T Hyman Rachel Marshall Gail P Jarvik Alun Meggy Erin Abner Georgina E Menzies Lee-Way Jin Ganna Leonenko Luis M Real Gyungah R Jun Clinton T Baldwin Detelina Grozeva Anna Karydas Giancarlo Russo Jeffrey A Kaye Ronald Kim Frank Jessen Neil W Kowall Bruno Vellas Joel H Kramer Emma Vardy Frank M LaFerla Karl-Heinz Jöckel James J Lah Martin Dichgans James B Leverenz David Mann Allan I Levey Stuart Pickering-Brown Andrew P Lieberman Norman Klopp Kathryn L Lunetta H-Erich Wichmann Constantine G Lyketsos Kevin Morgan Daniel C Marson Kristelle Brown Frank Martiniuk Christopher Medway Deborah C Mash Markus M Nöthen Eliezer Masliah Nigel M Hooper Wayne C McCormick Antonio Daniele Susan M McCurry Anthony Bayer Andrew N McDavid John Gallacher Ann C McKee Hendrik van den Bussche Marsel Mesulam Carol Brayne Bruce L Miller Steffi Riedel-Heller Carol A Miller Joshua W Miller Ammar Al-Chalabi John C Morris Christopher E Shaw Amanda J Myers Jens Wiltfang Sid O'Bryant John M Olichney Victoria Alvarez Joseph E Parisi Andrew B Singleton Henry L Paulson John Collinge William R Perry Simon Mead Elaine Peskind David H Cribbs Martin Rossor Aimee Pierce Natalie S Ryan Wayne W Poon Benedetta Nacmias Huntington Potter Sandro Sorbi Joseph F Quinn Eleonora Sacchinelli Ashok Raj Gianfranco Spalletta Murray Raskind Carlo Caltagirone Paola Bossù Maria Donata Orfei Barry Reisberg Robert Clarke Christiane Reitz A David Smith John M Ringman Donald Warden Erik D Roberson Gordon Wilcock Ekaterina Rogaeva Amalia Cecilia Bruni Howard J Rosen Maura Gallo Roger N Rosenberg Yoav Ben-Shlomo Mark A Sager Patrizia Mecocci Andrew J Saykin Pau Pastor Michael L Cuccaro Jeffery M Vance Julie A Schneider Lori S Schneider Susan Slifer William W Seeley Amanda G Smith Joshua A Sonnen Salvatore Spina Robert A Stern Russell H Swerdlow Mitchell Tang Rudolph E Tanzi John Q Trojanowski Juan C Troncoso Vivianna M Van Deerlin Linda J Van Eldik Harry V Vinters Jean Paul Vonsattel Sandra Weintraub Kathleen A Welsh-Bohmer Kirk C Wilhelmsen Jennifer Williamson Thomas S Wingo Randall L Woltjer Clinton B Wright Chang-En Yu Lei Yu Yasaman Saba Alberto Pilotto Maria J Bullido Oliver Peters Paul K Crane David Bennett Paola Bosco Eliecer Coto Virginia Boccardi Phil L De Jager Alberto Lleo Nick Warner Oscar L Lopez Martin Ingelsson Panagiotis Deloukas Carlos Cruchaga Caroline Graff Rhian Gwilliam Myriam Fornage Alison M Goate Pascual Sanchez-Juan Patrick G Kehoe Najaf Amin Nilifur Ertekin-Taner Claudine Berr Stéphanie Debette Seth Love Lenore J Launer Steven G Younkin Jean-Francois Dartigues Chris Corcoran M Arfan Ikram Dennis W Dickson Gael Nicolas Dominique Campion JoAnn Tschanz Helena Schmidt Hakon Hakonarson Jordi Clarimon Ron Munger Reinhold Schmidt Lindsay A Farrer Christine Van Broeckhoven Michael C O'Donovan Anita L DeStefano Lesley Jones Jonathan L Haines Jean-Francois Deleuze Michael J Owen Vilmundur Gudnason Richard Mayeux Valentina Escott-Price Bruce M Psaty Alfredo Ramirez Li-San Wang Agustin Ruiz Cornelia M van Duijn Peter A Holmans Sudha Seshadri Julie Williams Phillippe Amouyel Gerard D Schellenberg Jean-Charles Lambert Margaret A Pericak-Vance

Nat Genet 2019 03 28;51(3):414-430. Epub 2019 Feb 28.

John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.

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http://dx.doi.org/10.1038/s41588-019-0358-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463297PMC
March 2019

Impaired Spatial Reorientation in the 3xTg-AD Mouse Model of Alzheimer's Disease.

Sci Rep 2019 Feb 4;9(1):1311. Epub 2019 Feb 4.

Department of Psychology, Program in Neuroscience, Florida State University, Tallahassee, Florida, USA.

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http://dx.doi.org/10.1038/s41598-018-37151-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361963PMC
February 2019

Sex-dependent co-occurrence of hypoxia and β-amyloid plaques in hippocampus and entorhinal cortex is reversed by long-term treatment with ubiquinol and ascorbic acid in the 3 × Tg-AD mouse model of Alzheimer's disease.

Mol Cell Neurosci 2018 10 25;92:67-81. Epub 2018 Jun 25.

Department of Medical Sciences, Faculty of Medicine, University of Castilla-La Mancha, Spain; Oxidative Stress and Neurodegeneration Group, Regional Centre for Biomedical Research, University of Castilla-La Mancha, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.mcn.2018.06.005DOI Listing
October 2018

Sulforaphane Upregulates the Heat Shock Protein Co-Chaperone CHIP and Clears Amyloid-β and Tau in a Mouse Model of Alzheimer's Disease.

Mol Nutr Food Res 2018 06 28;62(12):e1800240. Epub 2018 May 28.

Department of Agricultural Biotechnology, Seoul National University, Seoul 08826, Republic of Korea.

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http://dx.doi.org/10.1002/mnfr.201800240DOI Listing
June 2018

Reversal of memory and neuropsychiatric symptoms and reduced tau pathology by selenium in 3xTg-AD mice.

Sci Rep 2018 Apr 24;8(1):6431. Epub 2018 Apr 24.

Institut de Neurociències, Departament de Bioquímica i Biologia Molecular, Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Universitat Autònoma de Barcelona, Bellaterra, 08193, Spain.

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http://dx.doi.org/10.1038/s41598-018-24741-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915484PMC
April 2018

Human Neural Stem Cell Transplantation Rescues Functional Deficits in R6/2 and Q140 Huntington's Disease Mice.

Stem Cell Reports 2018 01 7;10(1):58-72. Epub 2017 Dec 7.

Institute for Memory Impairment and Neurological Disorders, University of California, Irvine, 3400 Biological Sciences III, Irvine, CA 92697-4545, USA; Department of Neurobiology & Behavior, University of California, Irvine, 3400 Biological Sciences III, Irvine, CA 92697-4545, USA; Department of Psychiatry & Human Behavior, University of California, Irvine, 3400 Biological Sciences III, Irvine, CA 92697-4545, USA; Sue and Bill Gross Stem Cell Center, University of California, Irvine, Gross Hall, Room 3219, 845 Health Sciences Road, Irvine, CA 92697, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2017.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768890PMC
January 2018

Comparative profiling of cortical gene expression in Alzheimer's disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation.

Sci Rep 2017 12 19;7(1):17762. Epub 2017 Dec 19.

Division of Neurofunctional Genomics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.

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http://dx.doi.org/10.1038/s41598-017-17999-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736730PMC
December 2017

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease.

Authors:
Rebecca Sims Sven J van der Lee Adam C Naj Céline Bellenguez Nandini Badarinarayan Johanna Jakobsdottir Brian W Kunkle Anne Boland Rachel Raybould Joshua C Bis Eden R Martin Benjamin Grenier-Boley Stefanie Heilmann-Heimbach Vincent Chouraki Amanda B Kuzma Kristel Sleegers Maria Vronskaya Agustin Ruiz Robert R Graham Robert Olaso Per Hoffmann Megan L Grove Badri N Vardarajan Mikko Hiltunen Markus M Nöthen Charles C White Kara L Hamilton-Nelson Jacques Epelbaum Wolfgang Maier Seung-Hoan Choi Gary W Beecham Cécile Dulary Stefan Herms Albert V Smith Cory C Funk Céline Derbois Andreas J Forstner Shahzad Ahmad Hongdong Li Delphine Bacq Denise Harold Claudia L Satizabal Otto Valladares Alessio Squassina Rhodri Thomas Jennifer A Brody Liming Qu Pascual Sánchez-Juan Taniesha Morgan Frank J Wolters Yi Zhao Florentino Sanchez Garcia Nicola Denning Myriam Fornage John Malamon Maria Candida Deniz Naranjo Elisa Majounie Thomas H Mosley Beth Dombroski David Wallon Michelle K Lupton Josée Dupuis Patrice Whitehead Laura Fratiglioni Christopher Medway Xueqiu Jian Shubhabrata Mukherjee Lina Keller Kristelle Brown Honghuang Lin Laura B Cantwell Francesco Panza Bernadette McGuinness Sonia Moreno-Grau Jeremy D Burgess Vincenzo Solfrizzi Petra Proitsi Hieab H Adams Mariet Allen Davide Seripa Pau Pastor L Adrienne Cupples Nathan D Price Didier Hannequin Ana Frank-García Daniel Levy Paramita Chakrabarty Paolo Caffarra Ina Giegling Alexa S Beiser Vilmantas Giedraitis Harald Hampel Melissa E Garcia Xue Wang Lars Lannfelt Patrizia Mecocci Gudny Eiriksdottir Paul K Crane Florence Pasquier Virginia Boccardi Isabel Henández Robert C Barber Martin Scherer Lluis Tarraga Perrie M Adams Markus Leber Yuning Chen Marilyn S Albert Steffi Riedel-Heller Valur Emilsson Duane Beekly Anne Braae Reinhold Schmidt Deborah Blacker Carlo Masullo Helena Schmidt Rachelle S Doody Gianfranco Spalletta W T Longstreth Thomas J Fairchild Paola Bossù Oscar L Lopez Matthew P Frosch Eleonora Sacchinelli Bernardino Ghetti Qiong Yang Ryan M Huebinger Frank Jessen Shuo Li M Ilyas Kamboh John Morris Oscar Sotolongo-Grau Mindy J Katz Chris Corcoran Melanie Dunstan Amy Braddel Charlene Thomas Alun Meggy Rachel Marshall Amy Gerrish Jade Chapman Miquel Aguilar Sarah Taylor Matt Hill Mònica Díez Fairén Angela Hodges Bruno Vellas Hilkka Soininen Iwona Kloszewska Makrina Daniilidou James Uphill Yogen Patel Joseph T Hughes Jenny Lord James Turton Annette M Hartmann Roberta Cecchetti Chiara Fenoglio Maria Serpente Marina Arcaro Carlo Caltagirone Maria Donata Orfei Antonio Ciaramella Sabrina Pichler Manuel Mayhaus Wei Gu Alberto Lleó Juan Fortea Rafael Blesa Imelda S Barber Keeley Brookes Chiara Cupidi Raffaele Giovanni Maletta David Carrell Sandro Sorbi Susanne Moebus Maria Urbano Alberto Pilotto Johannes Kornhuber Paolo Bosco Stephen Todd David Craig Janet Johnston Michael Gill Brian Lawlor Aoibhinn Lynch Nick C Fox John Hardy Roger L Albin Liana G Apostolova Steven E Arnold Sanjay Asthana Craig S Atwood Clinton T Baldwin Lisa L Barnes Sandra Barral Thomas G Beach James T Becker Eileen H Bigio Thomas D Bird Bradley F Boeve James D Bowen Adam Boxer James R Burke Jeffrey M Burns Joseph D Buxbaum Nigel J Cairns Chuanhai Cao Chris S Carlson Cynthia M Carlsson Regina M Carney Minerva M Carrasquillo Steven L Carroll Carolina Ceballos Diaz Helena C Chui David G Clark David H Cribbs Elizabeth A Crocco Charles DeCarli Malcolm Dick Ranjan Duara Denis A Evans Kelley M Faber Kenneth B Fallon David W Fardo Martin R Farlow Steven Ferris Tatiana M Foroud Douglas R Galasko Marla Gearing Daniel H Geschwind John R Gilbert Neill R Graff-Radford Robert C Green John H Growdon Ronald L Hamilton Lindy E Harrell Lawrence S Honig Matthew J Huentelman Christine M Hulette Bradley T Hyman Gail P Jarvik Erin Abner Lee-Way Jin Gyungah Jun Anna Karydas Jeffrey A Kaye Ronald Kim Neil W Kowall Joel H Kramer Frank M LaFerla James J Lah James B Leverenz Allan I Levey Ge Li Andrew P Lieberman Kathryn L Lunetta Constantine G Lyketsos Daniel C Marson Frank Martiniuk Deborah C Mash Eliezer Masliah Wayne C McCormick Susan M McCurry Andrew N McDavid Ann C McKee Marsel Mesulam Bruce L Miller Carol A Miller Joshua W Miller John C Morris Jill R Murrell Amanda J Myers Sid O'Bryant John M Olichney Vernon S Pankratz Joseph E Parisi Henry L Paulson William Perry Elaine Peskind Aimee Pierce Wayne W Poon Huntington Potter Joseph F Quinn Ashok Raj Murray Raskind Barry Reisberg Christiane Reitz John M Ringman Erik D Roberson Ekaterina Rogaeva Howard J Rosen Roger N Rosenberg Mark A Sager Andrew J Saykin Julie A Schneider Lon S Schneider William W Seeley Amanda G Smith Joshua A Sonnen Salvatore Spina Robert A Stern Russell H Swerdlow Rudolph E Tanzi Tricia A Thornton-Wells John Q Trojanowski Juan C Troncoso Vivianna M Van Deerlin Linda J Van Eldik Harry V Vinters Jean Paul Vonsattel Sandra Weintraub Kathleen A Welsh-Bohmer Kirk C Wilhelmsen Jennifer Williamson Thomas S Wingo Randall L Woltjer Clinton B Wright Chang-En Yu Lei Yu Fabienne Garzia Feroze Golamaully Gislain Septier Sebastien Engelborghs Rik Vandenberghe Peter P De Deyn Carmen Muñoz Fernadez Yoland Aladro Benito Hakan Thonberg Charlotte Forsell Lena Lilius Anne Kinhult-Stählbom Lena Kilander RoseMarie Brundin Letizia Concari Seppo Helisalmi Anne Maria Koivisto Annakaisa Haapasalo Vincent Dermecourt Nathalie Fievet Olivier Hanon Carole Dufouil Alexis Brice Karen Ritchie Bruno Dubois Jayanadra J Himali C Dirk Keene JoAnn Tschanz Annette L Fitzpatrick Walter A Kukull Maria Norton Thor Aspelund Eric B Larson Ron Munger Jerome I Rotter Richard B Lipton María J Bullido Albert Hofman Thomas J Montine Eliecer Coto Eric Boerwinkle Ronald C Petersen Victoria Alvarez Fernando Rivadeneira Eric M Reiman Maura Gallo Christopher J O'Donnell Joan S Reisch Amalia Cecilia Bruni Donald R Royall Martin Dichgans Mary Sano Daniela Galimberti Peter St George-Hyslop Elio Scarpini Debby W Tsuang Michelangelo Mancuso Ubaldo Bonuccelli Ashley R Winslow Antonio Daniele Chuang-Kuo Wu Oliver Peters Benedetta Nacmias Matthias Riemenschneider Reinhard Heun Carol Brayne David C Rubinsztein Jose Bras Rita Guerreiro Ammar Al-Chalabi Christopher E Shaw John Collinge David Mann Magda Tsolaki Jordi Clarimón Rebecca Sussams Simon Lovestone Michael C O'Donovan Michael J Owen Timothy W Behrens Simon Mead Alison M Goate Andre G Uitterlinden Clive Holmes Carlos Cruchaga Martin Ingelsson David A Bennett John Powell Todd E Golde Caroline Graff Philip L De Jager Kevin Morgan Nilufer Ertekin-Taner Onofre Combarros Bruce M Psaty Peter Passmore Steven G Younkin Claudine Berr Vilmundur Gudnason Dan Rujescu Dennis W Dickson Jean-François Dartigues Anita L DeStefano Sara Ortega-Cubero Hakon Hakonarson Dominique Campion Merce Boada John Keoni Kauwe Lindsay A Farrer Christine Van Broeckhoven M Arfan Ikram Lesley Jones Jonathan L Haines Christophe Tzourio Lenore J Launer Valentina Escott-Price Richard Mayeux Jean-François Deleuze Najaf Amin Peter A Holmans Margaret A Pericak-Vance Philippe Amouyel Cornelia M van Duijn Alfredo Ramirez Li-San Wang Jean-Charles Lambert Sudha Seshadri Julie Williams Gerard D Schellenberg

Nat Genet 2017 09 17;49(9):1373-1384. Epub 2017 Jul 17.

Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1038/ng.3916DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669039PMC
September 2017

Synaptic Impairment in Alzheimer's Disease: A Dysregulated Symphony.

Trends Neurosci 2017 06 8;40(6):347-357. Epub 2017 May 8.

Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697, USA; Department of Neurobiology and Behavior, University of California, Irvine, CA 92697, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tins.2017.04.002DOI Listing
June 2017

Sulforaphane epigenetically enhances neuronal BDNF expression and TrkB signaling pathways.

Mol Nutr Food Res 2017 02 30;61(2). Epub 2016 Nov 30.

Center for Food and Bioconvergence, Seoul National University, Seoul, Republic of Korea.

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http://dx.doi.org/10.1002/mnfr.201600194DOI Listing
February 2017

Human mitochondrial transcriptional factor A breaks the mitochondria-mediated vicious cycle in Alzheimer's disease.

Sci Rep 2016 11 29;6:37889. Epub 2016 Nov 29.

Division of Neurofunctional Genomics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka 812-8582, Japan.

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http://dx.doi.org/10.1038/srep37889DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5126576PMC
November 2016

Activity of muscarinic, galanin and cannabinoid receptors in the prodromal and advanced stages in the triple transgenic mice model of Alzheimer's disease.

Neuroscience 2016 08 17;329:284-93. Epub 2016 May 17.

Department of Pharmacology, Faculty of Medicine, University of the Basque Country (UPV/EHU), B° Sarriena s/n, 48940 Leioa, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.neuroscience.2016.05.012DOI Listing
August 2016

Diabetes and Alzheimer's disease crosstalk.

Neurosci Biobehav Rev 2016 May 9;64:272-87. Epub 2016 Mar 9.

Department of Neurobiology and Behavior and Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697-4545, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neubiorev.2016.03.005DOI Listing
May 2016

7,8-Dihydroxyflavone, a small molecule TrkB agonist, improves spatial memory and increases thin spine density in a mouse model of Alzheimer disease-like neuronal loss.

PLoS One 2014 10;9(3):e91453. Epub 2014 Mar 10.

Institute for Memory Impairments and Neurological Disorders, University of California Irvine, Irvine, California, United States of America; Department of Neurobiology and Behavior, University of California Irvine, Irvine, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0091453PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948846PMC
March 2016

Accelerating stem cell trials for Alzheimer's disease.

Lancet Neurol 2016 02 17;15(2):219-230. Epub 2015 Dec 17.

Duke Institute for Brain Sciences, Duke University, Durham, NC, USA; Psychiatry Department, Duke University, Durham, NC, USA. Electronic address:

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http://dx.doi.org/10.1016/S1474-4422(15)00332-4DOI Listing
February 2016

Short-term modern life-like stress exacerbates Aβ-pathology and synapse loss in 3xTg-AD mice.

J Neurochem 2015 Sep 14;134(5):915-26. Epub 2015 Jul 14.

Department of Neurobiology and Behavior and Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA.

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http://dx.doi.org/10.1111/jnc.13195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792118PMC
September 2015

Synapse-specific IL-1 receptor subunit reconfiguration augments vulnerability to IL-1β in the aged hippocampus.

Proc Natl Acad Sci U S A 2015 Sep 24;112(36):E5078-87. Epub 2015 Aug 24.

Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697;

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http://dx.doi.org/10.1073/pnas.1514486112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568670PMC
September 2015

Repeated cognitive stimulation alleviates memory impairments in an Alzheimer's disease mouse model.

Brain Res Bull 2015 Aug 7;117:10-5. Epub 2015 Jul 7.

Department of Neurobiology and Behavior, University of California, Irvine, CA, USA; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.brainresbull.2015.07.001DOI Listing
August 2015

Upregulation of miR-181 decreases c-Fos and SIRT-1 in the hippocampus of 3xTg-AD mice.

J Alzheimers Dis 2014 ;42(4):1229-38

School of Natural Sciences, University of California, Merced, CA, USA.

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http://dx.doi.org/10.3233/JAD-140204DOI Listing
July 2015

Hippocampal adaptive response following extensive neuronal loss in an inducible transgenic mouse model.

PLoS One 2014 3;9(9):e106009. Epub 2014 Sep 3.

Department of Neurobiology and Behavior and Institute for Memory Impairments and Neurological Disorders, University of California Irvine, Irvine, California, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4153578PMC
May 2015

Rarity of the Alzheimer disease-protective APP A673T variant in the United States.

Authors:
Li-San Wang Adam C Naj Robert R Graham Paul K Crane Brian W Kunkle Carlos Cruchaga Josue D Gonzalez Murcia Lisa Cannon-Albright Clinton T Baldwin Henrik Zetterberg Kaj Blennow Walter A Kukull Kelley M Faber Nicole Schupf Maria C Norton JoAnn T Tschanz Ronald G Munger Christopher D Corcoran Ekaterina Rogaeva Chiao-Feng Lin Beth A Dombroski Laura B Cantwell Amanda Partch Otto Valladares Hakon Hakonarson Peter St George-Hyslop Robert C Green Alison M Goate Tatiana M Foroud Regina M Carney Eric B Larson Timothy W Behrens John S K Kauwe Jonathan L Haines Lindsay A Farrer Margaret A Pericak-Vance Richard Mayeux Gerard D Schellenberg Marilyn S Albert Roger L Albin Liana G Apostolova Steven E Arnold Robert Barber Michael Barmada Lisa L Barnes Thomas G Beach James T Becker Gary W Beecham Duane Beekly David A Bennett Eileen H Bigio Thomas D Bird Deborah Blacker Bradley F Boeve James D Bowen Adam Boxer James R Burke Joseph D Buxbaum Nigel J Cairns Chuanhai Cao Chris S Carlson Steven L Carroll Helena C Chui David G Clark David H Cribbs Elizabeth A Crocco Charles DeCarli Steven T DeKosky F Yesim Demirci Malcolm Dick Dennis W Dickson Ranjan Duara Nilufer Ertekin-Taner Kenneth B Fallon Martin R Farlow Steven Ferris Matthew P Frosch Douglas R Galasko Mary Ganguli Marla Gearing Daniel H Geschwind Bernardino Ghetti John R Gilbert Jonathan D Glass Neill R Graff-Radford John H Growdon Ronald L Hamilton Kara L Hamilton-Nelson Lindy E Harrell Elizabeth Head Lawrence S Honig Christine M Hulette Bradley T Hyman Gail P Jarvik Gregory A Jicha Lee-Way Jin Gyungah Jun Gyungah Jun M Ilyas Kamboh Anna Karydas Jeffrey A Kaye Ronald Kim Edward H Koo Neil W Kowall Joel H Kramer Frank M LaFerla James J Lah James B Leverenz Allan I Levey Gei Li Andrew P Lieberman Oscar L Lopez Kathryn L Lunetta Constantine G Lyketsos Wendy J Mack Daniel C Marson Eden R Martin Frank Martiniuk Deborah C Mash Eliezer Masliah Wayne C McCormick Susan M McCurry Andrew N McDavid Ann C McKee W Marsel Mesulam Bruce L Miller Carol A Miller Joshua W Miller Thomas J Montine John C Morris Jill R Murrell John M Olichney Joseph E Parisi William Perry Elaine Peskind Ronald C Petersen Aimee Pierce Wayne W Poon Huntington Potter Joseph F Quinn Ashok Raj Murray Raskind Eric M Reiman Barry Reisberg Christiane Reitz John M Ringman Erik D Roberson Howard J Rosen Roger N Rosenberg Mary Sano Andrew J Saykin Julie A Schneider Lon S Schneider William W Seeley Amanda G Smith Joshua A Sonnen Salvatore Spina Robert A Stern Rudolph E Tanzi Tricia A Thornton-Wells John Q Trojanowski Juan C Troncoso Debby W Tsuang Vivianna M Van Deerlin Linda J Van Eldik Badri N Vardarajan Harry V Vinters Jean Paul Vonsattel Sandra Weintraub Kathleen A Welsh-Bohmer Jennifer Williamson Sarah Wishnek Randall L Woltjer Clinton B Wright Steven G Younkin Chang-En Yu Lei Yu

JAMA Neurol 2015 Feb;72(2):209-16

Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia.

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http://dx.doi.org/10.1001/jamaneurol.2014.2157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324097PMC
February 2015

Disease modifying effect of chronic oral treatment with a neurotrophic peptidergic compound in a triple transgenic mouse model of Alzheimer's disease.

Neurobiol Dis 2014 Nov 15;71:110-30. Epub 2014 Jul 15.

Department of Neurochemistry, Inge-Grundke Iqbal Research Floor, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2014.07.001DOI Listing
November 2014

Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study.

Authors:
Adam C Naj Gyungah Jun Christiane Reitz Brian W Kunkle William Perry Yo Son Park Gary W Beecham Ruchita A Rajbhandary Kara L Hamilton-Nelson Li-San Wang John S K Kauwe Matthew J Huentelman Amanda J Myers Thomas D Bird Bradley F Boeve Clinton T Baldwin Gail P Jarvik Paul K Crane Ekaterina Rogaeva M Michael Barmada F Yesim Demirci Carlos Cruchaga Patricia L Kramer Nilufer Ertekin-Taner John Hardy Neill R Graff-Radford Robert C Green Eric B Larson Peter H St George-Hyslop Joseph D Buxbaum Denis A Evans Julie A Schneider Kathryn L Lunetta M Ilyas Kamboh Andrew J Saykin Eric M Reiman Philip L De Jager David A Bennett John C Morris Thomas J Montine Alison M Goate Deborah Blacker Debby W Tsuang Hakon Hakonarson Walter A Kukull Tatiana M Foroud Eden R Martin Jonathan L Haines Richard P Mayeux Lindsay A Farrer Gerard D Schellenberg Margaret A Pericak-Vance Marilyn S Albert Roger L Albin Liana G Apostolova Steven E Arnold Robert Barber Lisa L Barnes Thomas G Beach James T Becker Duane Beekly Eileen H Bigio James D Bowen Adam Boxer James R Burke Nigel J Cairns Laura B Cantwell Chuanhai Cao Chris S Carlson Regina M Carney Minerva M Carrasquillo Steven L Carroll Helena C Chui David G Clark Jason Corneveaux David H Cribbs Elizabeth A Crocco Charles DeCarli Steven T DeKosky Malcolm Dick Dennis W Dickson Ranjan Duara Kelley M Faber Kenneth B Fallon Martin R Farlow Steven Ferris Matthew P Frosch Douglas R Galasko Mary Ganguli Marla Gearing Daniel H Geschwind Bernardino Ghetti John R Gilbert Jonathan D Glass John H Growdon Ronald L Hamilton Lindy E Harrell Elizabeth Head Lawrence S Honig Christine M Hulette Bradley T Hyman Gregory A Jicha Lee-Way Jin Anna Karydas Jeffrey A Kaye Ronald Kim Edward H Koo Neil W Kowall Joel H Kramer Frank M LaFerla James J Lah James B Leverenz Allan I Levey Ge Li Andrew P Lieberman Chiao-Feng Lin Oscar L Lopez Constantine G Lyketsos Wendy J Mack Frank Martiniuk Deborah C Mash Eliezer Masliah Wayne C McCormick Susan M McCurry Andrew N McDavid Ann C McKee Marsel Mesulam Bruce L Miller Carol A Miller Joshua W Miller Jill R Murrell John M Olichney Vernon S Pankratz Joseph E Parisi Henry L Paulson Elaine Peskind Ronald C Petersen Aimee Pierce Wayne W Poon Huntington Potter Joseph F Quinn Ashok Raj Murray Raskind Barry Reisberg John M Ringman Erik D Roberson Howard J Rosen Roger N Rosenberg Mary Sano Lon S Schneider William W Seeley Amanda G Smith Joshua A Sonnen Salvatore Spina Robert A Stern Rudolph E Tanzi Tricia A Thornton-Wells John Q Trojanowski Juan C Troncoso Otto Valladares Vivianna M Van Deerlin Linda J Van Eldik Badri N Vardarajan Harry V Vinters Jean Paul Vonsattel Sandra Weintraub Kathleen A Welsh-Bohmer Jennifer Williamson Sarah Wishnek Randall L Woltjer Clinton B Wright Steven G Younkin Chang-En Yu Lei Yu

JAMA Neurol 2014 Nov;71(11):1394-404

Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois.

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http://dx.doi.org/10.1001/jamaneurol.2014.1491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4314944PMC
November 2014

Altered expression of diabetes-related genes in Alzheimer's disease brains: the Hisayama study.

Cereb Cortex 2014 Sep 17;24(9):2476-88. Epub 2013 Apr 17.

Division of Neurofunctional Genomics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Research Center for Nucleotide Pool.

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http://dx.doi.org/10.1093/cercor/bht101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128707PMC
September 2014

p-Tau immunotherapy reduces soluble and insoluble tau in aged 3xTg-AD mice.

Neurosci Lett 2014 Jul 2;575:96-100. Epub 2014 Jun 2.

Department of Neurobiology and Behavior, University of California, Irvine, CA, United States; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, United States. Electronic address:

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http://dx.doi.org/10.1016/j.neulet.2014.05.047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437620PMC
July 2014

Optical imaging in an Alzheimer's mouse model reveals amyloid--dependent vascular impairment.

Neurophotonics 2014 Jul;1(1):011005

Beckman Laser Institute and Medical Clinic, Laser Microbeam and Medical Program, 1002 Health Sciences Road, Irvine, California 92612 ; University of California Irvine, Department of Biomedical Engineering, 3120 Natural Sciences II, Irvine, California 92697-2715.

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http://dx.doi.org/10.1117/1.NPh.1.1.011005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132842PMC
July 2014

Synergistic effects of amyloid-beta and wild-type human tau on dendritic spine loss in a floxed double transgenic model of Alzheimer's disease.

Neurobiol Dis 2014 Apr 14;64:107-17. Epub 2014 Jan 14.

Institute for Memory Impairments and Neurological Disorders, Irvine, CA, USA; Department of Neurobiology and Behavior, University of California, Irvine, CA 92697-4550, USA. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2014.01.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4072239PMC
April 2014

Genetic ablation of tau mitigates cognitive impairment induced by type 1 diabetes.

Am J Pathol 2014 Mar 7;184(3):819-26. Epub 2014 Jan 7.

Department of Neurobiology and Behavior, Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2013.11.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936327PMC
March 2014

Endogenous murine tau promotes neurofibrillary tangles in 3xTg-AD mice without affecting cognition.

Neurobiol Dis 2014 Feb 29;62:407-15. Epub 2013 Oct 29.

Department of Neurobiology and Behavior, Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697-4545, USA. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2013.10.019DOI Listing
February 2014

α7 Nicotinic receptor agonist enhances cognition in aged 3xTg-AD mice with robust plaques and tangles.

Am J Pathol 2014 Feb 19;184(2):520-9. Epub 2013 Nov 19.

Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California; Department of Neurobiology and Behavior, University of California, Irvine, California. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2013.10.010DOI Listing
February 2014

Mifepristone alters amyloid precursor protein processing to preclude amyloid beta and also reduces tau pathology.

Biol Psychiatry 2013 Sep 8;74(5):357-66. Epub 2013 Jan 8.

Department of Neurobiology and Behavior, University of California, Irvine, USA.

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http://dx.doi.org/10.1016/j.biopsych.2012.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3633722PMC
September 2013

Reversible epigenetic histone modifications and Bdnf expression in neurons with aging and from a mouse model of Alzheimer's disease.

Age (Dordr) 2013 Jun 12;35(3):519-31. Epub 2012 Jan 12.

Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL 62794-9626, USA.

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http://dx.doi.org/10.1007/s11357-011-9375-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636384PMC
June 2013

Elucidating the triggers, progression, and effects of Alzheimer's disease.

J Alzheimers Dis 2013 ;33 Suppl 1:S195-210

Department of Neurobiology and Behavior and Institute of Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697-4545, USA.

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http://dx.doi.org/10.3233/JAD-2012-129009DOI Listing
June 2013

Brain gene expression of a sporadic (icv-STZ Mouse) and a familial mouse model (3xTg-AD mouse) of Alzheimer's disease.

PLoS One 2012 7;7(12):e51432. Epub 2012 Dec 7.

Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0051432PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3517562PMC
June 2013

The bradykinin B1 receptor regulates Aβ deposition and neuroinflammation in Tg-SwDI mice.

Am J Pathol 2013 May 5;182(5):1740-9. Epub 2013 Mar 5.

Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA 92697-4540, USA.

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http://dx.doi.org/10.1016/j.ajpath.2013.01.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3644719PMC
May 2013

Aspirin-triggered lipoxin A4 stimulates alternative activation of microglia and reduces Alzheimer disease-like pathology in mice.

Am J Pathol 2013 May 16;182(5):1780-9. Epub 2013 Mar 16.

Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA 92697-4545, USA.

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http://dx.doi.org/10.1016/j.ajpath.2013.01.051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3644736PMC
May 2013

Early increases in soluble amyloid-β levels coincide with cholinergic degeneration in 3xTg-AD mice.

J Alzheimers Dis 2012 ;32(2):267-72

Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Biological Sciences, Brain Sciences, Toronto, ON, Canada.

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http://dx.doi.org/10.3233/JAD-2012-100732DOI Listing
April 2013

APP knockout mice experience acute mortality as the result of ischemia.

PLoS One 2012 9;7(8):e42665. Epub 2012 Aug 9.

Institute for Memory Impairments and Neurological Disorders, University of California Irvine, Irvine, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0042665PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3415410PMC
April 2013

Sustained interleukin-1β overexpression exacerbates tau pathology despite reduced amyloid burden in an Alzheimer's mouse model.

J Neurosci 2013 Mar;33(11):5053-64

Department of Neurobiology and Anatomy, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.4361-12.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3637949PMC
March 2013

Genetic knockdown of brain-derived neurotrophic factor in 3xTg-AD mice does not alter Aβ or tau pathology.

PLoS One 2012 3;7(8):e39566. Epub 2012 Aug 3.

Institute for Memory Impairments and Neurological Disorders, University of California Irvine, Irvine, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0039566PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411687PMC
February 2013

Intracellular accumulation of toxic turn amyloid-β is associated with endoplasmic reticulum stress in Alzheimer's disease.

Curr Alzheimer Res 2013 Jan;10(1):11-20

Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.

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January 2013

Astrocytes: conductors of the Alzheimer disease neuroinflammatory symphony.

Exp Neurol 2013 Jan 11;239:133-8. Epub 2012 Oct 11.

Institute for Memory Impairments and Neurological Disorders, Department of Neurobiology and Behavior, University of California, Irvine, CA 92697-4545, USA.

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http://dx.doi.org/10.1016/j.expneurol.2012.10.007DOI Listing
January 2013

Sortilin is required for toxic action of Aβ oligomers (AβOs): extracellular AβOs trigger apoptosis, and intraneuronal AβOs impair degradation pathways.

Life Sci 2012 Dec 3;91(23-24):1177-86. Epub 2012 May 3.

Department of Neurology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Aomori, Japan.

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http://dx.doi.org/10.1016/j.lfs.2012.04.038DOI Listing
December 2012

Presenilin-null cells have altered two-pore calcium channel expression and lysosomal calcium: implications for lysosomal function.

Brain Res 2012 Dec 24;1489:8-16. Epub 2012 Oct 24.

Department of Neurobiology and Behavior, University of California, Irvine, 3208 Biological Sciences III, Irvine, CA 92697-4545, United States.

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http://dx.doi.org/10.1016/j.brainres.2012.10.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516298PMC
December 2012

Animal models of Alzheimer disease.

Cold Spring Harb Perspect Med 2012 Nov 1;2(11). Epub 2012 Nov 1.

Institute for Memory Impairments and Neurological Disorders, Department of Neurobiology and Behavior, University of California, Irvine, 92697-4545, USA.

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http://dx.doi.org/10.1101/cshperspect.a006320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3543097PMC
November 2012

Soluble aβ promotes wild-type tau pathology in vivo.

J Neurosci 2012 Nov;32(48):17345-50

Department of Neurobiology and Behavior, Institute for Memory Impairment and Neurological Disorders, and Sue and Bill Gross Stem Cell Research Center, University of California Irvine, Irvine, California 92697, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.0172-12.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586232PMC
November 2012

Restoration of dopamine release deficits during object recognition memory acquisition attenuates cognitive impairment in a triple transgenic mice model of Alzheimer's disease.

Learn Mem 2012 Sep 14;19(10):453-60. Epub 2012 Sep 14.

Departamento de Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, 04510 México D.F., Mexico.

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http://dx.doi.org/10.1101/lm.026070.112DOI Listing
September 2012

Calpain inhibitor A-705253 mitigates Alzheimer's disease-like pathology and cognitive decline in aged 3xTgAD mice.

Am J Pathol 2012 Aug 9;181(2):616-25. Epub 2012 Jun 9.

Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California 92697-4545, USA.

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http://dx.doi.org/10.1016/j.ajpath.2012.04.020DOI Listing
August 2012

Preclinical success against Alzheimer's disease with an old drug.

Authors:
Frank M LaFerla

N Engl J Med 2012 Aug;367(6):570-2

Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, USA.

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http://dx.doi.org/10.1056/NEJMcibr1204890DOI Listing
August 2012

Transgenic mouse models of Alzheimer disease: developing a better model as a tool for therapeutic interventions.

Curr Pharm Des 2012 ;18(8):1131-47

School of Natural Sciences, University of California, Merced, CA 95343, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437619PMC
http://dx.doi.org/10.2174/138161212799315786DOI Listing
July 2012

13-Desmethyl spirolide-C is neuroprotective and reduces intracellular Aβ and hyperphosphorylated tau in vitro.

Neurochem Int 2011 Dec 30;59(7):1056-65. Epub 2011 Aug 30.

Departamento de Farmacología, Facultad de Veterinaria, Universidad de Santiago de Compostela, 27003 Lugo, Spain.

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http://dx.doi.org/10.1016/j.neuint.2011.08.013DOI Listing
December 2011

Blocking IL-1 signaling rescues cognition, attenuates tau pathology, and restores neuronal β-catenin pathway function in an Alzheimer's disease model.

J Immunol 2011 Dec 16;187(12):6539-49. Epub 2011 Nov 16.

Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA 92697, USA.

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http://dx.doi.org/10.4049/jimmunol.1100620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4072218PMC
December 2011

The role of tau in Alzheimer's disease and related disorders.

CNS Neurosci Ther 2011 Oct 14;17(5):514-24. Epub 2010 Jun 14.

Department of Neurobiology and Behavior and Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA.

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http://dx.doi.org/10.1111/j.1755-5949.2010.00177.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4072215PMC
October 2011

The cholinergic antagonist gymnodimine improves Aβ and tau neuropathology in an in vitro model of Alzheimer disease.

Cell Physiol Biochem 2011 17;27(6):783-94. Epub 2011 Jun 17.

Departamento de Farmacología, Facultad de Veterinaria, Universidad de Santiago de Compostela, 27003 Lugo, Spain.

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http://dx.doi.org/10.1159/000330086DOI Listing
October 2011

Olfactory memory is impaired in a triple transgenic model of Alzheimer disease.

Behav Brain Res 2011 Oct 30;224(2):408-12. Epub 2011 Jun 30.

Department of Biomedical Sciences, University of Foggia, Foggia, 71100, Italy.

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http://dx.doi.org/10.1016/j.bbr.2011.06.029DOI Listing
October 2011

Physical exercise protects against Alzheimer's disease in 3xTg-AD mice.

J Alzheimers Dis 2011 ;24(3):421-54

Institute of Biomedical Research of Barcelona (IIBB), CSIC-IDIBAPS, Barcelona, Spain.

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http://dx.doi.org/10.3233/JAD-2011-101635DOI Listing
September 2011

Anesthesia in presymptomatic Alzheimer's disease: a study using the triple-transgenic mouse model.

Alzheimers Dement 2011 Sep 13;7(5):521-531.e1. Epub 2011 Jul 13.

Department of Anesthesiology and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.

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http://dx.doi.org/10.1016/j.jalz.2010.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3167023PMC
September 2011

Loss of muscarinic M1 receptor exacerbates Alzheimer's disease-like pathology and cognitive decline.

Am J Pathol 2011 Aug 23;179(2):980-91. Epub 2011 Jun 23.

Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California 92697-4545, USA.

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http://dx.doi.org/10.1016/j.ajpath.2011.04.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157199PMC
August 2011

Soluble amyloid precursor protein induces rapid neural differentiation of human embryonic stem cells.

J Biol Chem 2011 Jul 23;286(27):24264-74. Epub 2011 May 23.

Department of Neurobiology and Behavior and Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California 92697, USA.

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http://dx.doi.org/10.1074/jbc.M111.227421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3129207PMC
July 2011

Inflammation induced by infection potentiates tau pathological features in transgenic mice.

Am J Pathol 2011 Jun 30;178(6):2811-22. Epub 2011 Apr 30.

Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA.

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http://dx.doi.org/10.1016/j.ajpath.2011.02.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3124234PMC
June 2011

ST101 induces a novel 17 kDa APP cleavage that precludes Aβ generation in vivo.

Ann Neurol 2011 May 17;69(5):831-44. Epub 2011 Mar 17.

From the Department of Neurobiology and Behavior Institute for Memory Impairments and Neurological Disorders, University of California at Irvine, Irvine, CA 92697-4545, USA.

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http://dx.doi.org/10.1002/ana.22325DOI Listing
May 2011

Early dysregulation of the mitochondrial proteome in a mouse model of Alzheimer's disease.

J Proteomics 2011 Apr 13;74(4):466-79. Epub 2011 Jan 13.

Department of Molecular and Cell Biology, The University of Texas at Dallas, Richardson, TX 75080, USA.

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http://dx.doi.org/10.1016/j.jprot.2010.12.012DOI Listing
April 2011

Spatial frequency domain imaging of intrinsic optical property contrast in a mouse model of Alzheimer's disease.

Ann Biomed Eng 2011 Apr 19;39(4):1349-57. Epub 2011 Feb 19.

Laser Microbeam and Medical Program, Beckman Laser Institute and Medical Clinic, 1002 Health Sciences Road, Irvine, CA 92612, USA.

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http://dx.doi.org/10.1007/s10439-011-0269-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3069335PMC
April 2011

Proflavine derivatives as fluorescent imaging agents of amyloid deposits.

Bioorg Med Chem Lett 2011 Apr 6;21(8):2203-6. Epub 2011 Mar 6.

INSERM, Unit U877, J Fourier University, La Tronche, France.

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http://dx.doi.org/10.1016/j.bmcl.2011.03.010DOI Listing
April 2011

Apomorphine treatment in Alzheimer mice promoting amyloid-β degradation.

Ann Neurol 2011 Feb;69(2):248-56

Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

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http://dx.doi.org/10.1002/ana.22319DOI Listing
February 2011

Presenilin is necessary for efficient proteolysis through the autophagy-lysosome system in a γ-secretase-independent manner.

J Neurosci 2011 Feb;31(8):2781-91

Department of Neurobiology and Behavior and Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, California 92697-4545, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.5156-10.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3064964PMC
February 2011

Reductions in amyloid-beta-derived neuroinflammation, with minocycline, restore cognition but do not significantly affect tau hyperphosphorylation.

J Alzheimers Dis 2010 ;21(2):527-42

Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697-4545, USA.

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http://dx.doi.org/10.3233/JAD-2010-100204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4085054PMC
December 2010

Pharmacologic reversal of neurogenic and neuroplastic abnormalities and cognitive impairments without affecting Aβ and tau pathologies in 3xTg-AD mice.

Acta Neuropathol 2010 Nov 10;120(5):605-21. Epub 2010 Aug 10.

Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, 10314, USA.

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http://link.springer.com/10.1007/s00401-010-0734-6
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http://dx.doi.org/10.1007/s00401-010-0734-6DOI Listing
November 2010

Formulation of a medical food cocktail for Alzheimer's disease: beneficial effects on cognition and neuropathology in a mouse model of the disease.

PLoS One 2010 Nov 17;5(11):e14015. Epub 2010 Nov 17.

Department of Neurobiology and Behavior, Institute for Memory Impairments and Neurological Disorders, University of California Irvine, Irvine, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0014015PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2984445PMC
November 2010

Characterization of the 3xTg-AD mouse model of Alzheimer's disease: part 1. Circadian changes.

Brain Res 2010 Aug 31;1348:139-48. Epub 2010 May 31.

Department of Psychology, University of Calgary, 2500 University Dr. NW, Calgary, AB, Canada T2N 1N4.

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http://dx.doi.org/10.1016/j.brainres.2010.05.013DOI Listing
August 2010

Characterization of the 3xTg-AD mouse model of Alzheimer's disease: part 2. Behavioral and cognitive changes.

Brain Res 2010 Aug 15;1348:149-55. Epub 2010 Jun 15.

Department of Psychology, University of Calgary, 2500 University Dr. NW, Calgary, AB, Canada T2N 1N4.

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http://dx.doi.org/10.1016/j.brainres.2010.06.011DOI Listing
August 2010

Pathways linking Abeta and tau pathologies.

Authors:
Frank M LaFerla

Biochem Soc Trans 2010 Aug;38(4):993-5

Department of Neurobiology and Behavior and Institute for Memory Impairments and Neurological Disorders, University of California Irvine, Irvine, CA 92697, USA.

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http://dx.doi.org/10.1042/BST0380993DOI Listing
August 2010

Oligemic hypoperfusion differentially affects tau and amyloid-{beta}.

Am J Pathol 2010 Jul 14;177(1):300-10. Epub 2010 May 14.

Department of Neurobiology and Behavior, Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, 3212 Biological Sciences III, Irvine, CA 92697-4545, USA.

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http://dx.doi.org/10.2353/ajpath.2010.090750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2893673PMC
July 2010

Synergistic Interactions between Abeta, tau, and alpha-synuclein: acceleration of neuropathology and cognitive decline.

J Neurosci 2010 May;30(21):7281-9

Department of Neurobiology and Behavior, University of California, Irvine, Irvine, California 92697-4545, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.0490-10.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308018PMC
May 2010

Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease.

Nat Neurosci 2010 Apr 21;13(4):411-3. Epub 2010 Mar 21.

Center of Neuropathology and Prion Research, Ludwig-Maximilians-University, Munich, Germany.

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http://dx.doi.org/10.1038/nn.2511DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4072212PMC
April 2010

Alzheimer's disease.

N Engl J Med 2010 Jan;362(4):329-44

Department of Neurology, Caritas St. Elizabeth's Medical Center, Brighton, MA, USA.

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http://dx.doi.org/10.1056/NEJMra0909142DOI Listing
January 2010