Publications by authors named "Frank J Slack"

100Publications

Formulation of PLGA nanoparticles containing short cationic peptide nucleic acids.

MethodsX 2020 22;7:101115. Epub 2020 Oct 22.

Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT, 06269, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mex.2020.101115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7596289PMC
October 2020

Photodestruction of Stromal Fibroblasts Enhances Tumor Response to PDT in 3D Pancreatic Cancer Coculture Models.

Photochem Photobiol 2020 Oct 4. Epub 2020 Oct 4.

Department of Physics, University of Massachusetts at Boston, Boston, MA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/php.13339DOI Listing
October 2020

Next generation miRNA inhibition using short anti-seed PNAs encapsulated in PLGA nanoparticles.

J Control Release 2020 Nov 21;327:406-419. Epub 2020 Aug 21.

Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT 06269, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jconrel.2020.08.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7606596PMC
November 2020

TRIM71 binds to IMP1 and is capable of positive and negative regulation of target RNAs.

Cell Cycle 2020 Sep 20;19(18):2314-2326. Epub 2020 Aug 20.

HMS Initiative for RNA Medicine, Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School , Boston, MA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/15384101.2020.1804232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7513864PMC
September 2020

Challenges identifying efficacious miRNA therapeutics for cancer.

Expert Opin Drug Discov 2020 Sep 18;15(9):987-992. Epub 2020 May 18.

HMS Initiative for RNA Medicine, Department of Pathology, Beth, Israel Deaconess Medical Center/Harvard Medical School , Boston, MA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/17460441.2020.1765770DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415578PMC
September 2020

Spatially resolved and multiplexed MicroRNA quantification from tissue using nanoliter well arrays.

Microsyst Nanoeng 2020 9;6:51. Epub 2020 May 9.

1Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139 USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41378-020-0169-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211184PMC
May 2020

ADAR1-mediated RNA editing is a novel oncogenic process in thyroid cancer and regulates miR-200 activity.

Oncogene 2020 04 10;39(18):3738-3753. Epub 2020 Mar 10.

Instituto de Investigaciones Biomédicas "Alberto Sols"; Consejo Superior de Investigaciones Científicas (CSIC), Universidad Autónoma de Madrid (UAM), Madrid, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41388-020-1248-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190574PMC
April 2020

A High-Throughput Small Molecule Screen Identifies Ouabain as Synergistic with miR-34a in Killing Lung Cancer Cells.

iScience 2020 Feb 1;23(2):100878. Epub 2020 Feb 1.

HMS Initiative for RNA Medicine and Department of Pathology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.isci.2020.100878DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031322PMC
February 2020

Hydrophobically Modified let-7b miRNA Enhances Biodistribution to NSCLC and Downregulates HMGA2 In Vivo.

Mol Ther Nucleic Acids 2020 Mar 18;19:267-277. Epub 2019 Nov 18.

HMS Initiative for RNA Medicine, Department of Pathology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.omtn.2019.11.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6926262PMC
March 2020

The Role of Non-coding RNAs in Oncology.

Cell 2019 11;179(5):1033-1055

Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA; Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA; Department of Urology, University of Michigan, Ann Arbor, MI 48109, USA; Howard Hughes Medical Institute, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cell.2019.10.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347159PMC
November 2019

miR-155 as a novel clinical target for hematological malignancies.

Carcinogenesis 2020 03;41(1):2-7

HMS Initiative for RNA Medicine, Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/carcin/bgz183DOI Listing
March 2020

miR-147b-mediated TCA cycle dysfunction and pseudohypoxia initiate drug tolerance to EGFR inhibitors in lung adenocarcinoma.

Nat Metab 2019 Apr 8;1(4):460-474. Epub 2019 Apr 8.

HMS Initiative for RNA Medicine, Department of Pathology, Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s42255-019-0052-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750230PMC
April 2019

Tumor penetrating nanomedicine targeting both an oncomiR and an oncogene in pancreatic cancer.

Oncotarget 2019 Sep 3;10(51):5349-5358. Epub 2019 Sep 3.

HMS Initiative for RNA Medicine, Department of Pathology, Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.

View Article

Download full-text PDF

Source
http://www.oncotarget.com/fulltext/27160
Publisher Site
http://dx.doi.org/10.18632/oncotarget.27160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731108PMC
September 2019

Extracellular vesicles show promise for cancer theranostics.

Ann Transl Med 2019 Apr;7(7):158

HMS Initiative for RNA Medicine, Department of Pathology, Beth Israel Deaconess Medical Center/Harvard Medical School, 330 Brookline Avenue, Boston, MA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21037/atm.2019.03.19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511551PMC
April 2019

Epstein-Barr virus: From kisses to cancer, an ingenious immune evader.

Oncotarget 2018 Nov 23;9(92):36411-36412. Epub 2018 Nov 23.

Harvard Medical School Initiative for RNA Medicine, BIDMC, Harvard Medical School, Boston, MA, USA.

View Article

Download full-text PDF

Source
http://www.oncotarget.com/fulltext/26381
Publisher Site
http://dx.doi.org/10.18632/oncotarget.26381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284857PMC
November 2018

Human nuclear RNAi-defective 2 (NRDE2) is an essential RNA splicing factor.

RNA 2019 03 11;25(3):352-363. Epub 2018 Dec 11.

HMS Initiative for RNA Medicine, Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1261/rna.069773.118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380277PMC
March 2019

miR-155 drives oncogenesis by promoting and cooperating with mutations in the c-Kit oncogene.

Oncogene 2019 03 20;38(12):2151-2161. Epub 2018 Nov 20.

HMS Initiative for RNA Medicine, Department of Pathology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA, 02115, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41388-018-0571-yDOI Listing
March 2019

Let-7 microRNA as a potential therapeutic target with implications for immunotherapy.

Expert Opin Ther Targets 2018 11 17;22(11):929-939. Epub 2018 Oct 17.

a Harvard Medical School initiative for RNA Medicine, Department of Pathology , Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School , Boston , MA , USA.

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/14728222.2018.1
Publisher Site
http://dx.doi.org/10.1080/14728222.2018.1535594DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337723PMC
November 2018

Nonfouling, Encoded Hydrogel Microparticles for Multiplex MicroRNA Profiling Directly from Formalin-Fixed, Paraffin-Embedded Tissue.

Anal Chem 2018 09 14;90(17):10279-10285. Epub 2018 Aug 14.

Department of Chemical Engineering , Massachusetts Institute of Technology , Cambridge , Massachusetts 02139 , United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.analchem.8b02010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327312PMC
September 2018

The Nefarious Nexus of Noncoding RNAs in Cancer.

Int J Mol Sci 2018 Jul 17;19(7). Epub 2018 Jul 17.

HMS Initiative for RNA Medicine, Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms19072072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073630PMC
July 2018

Quantitative and multiplex microRNA assays from unprocessed cells in isolated nanoliter well arrays.

Lab Chip 2018 08;18(16):2410-2424

Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/c8lc00498fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081239PMC
August 2018

Tackling Tumors with Small RNAs Derived from Transfer RNA.

Authors:
Frank J Slack

N Engl J Med 2018 05;378(19):1842-1843

From the Harvard Medical School Initiative for RNA Medicine, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMcibr1716989DOI Listing
May 2018

Personalized RNA Medicine for Pancreatic Cancer.

Clin Cancer Res 2018 04 12;24(7):1734-1747. Epub 2018 Jan 12.

Harvard Medical School Initiative for RNA Medicine, Department of Pathology, Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1078-0432.CCR-17-2733DOI Listing
April 2018

lin-4 and the NRDE pathway are required to activate a transgenic lin-4 reporter but not the endogenous lin-4 locus in C. elegans.

PLoS One 2018 11;13(1):e0190766. Epub 2018 Jan 11.

Institute for RNA Medicine, Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0190766PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5764303PMC
February 2018

Non-coding RNA networks in cancer.

Nat Rev Cancer 2018 Jan 24;18(1):5-18. Epub 2017 Nov 24.

Harvard Medical School Initiative for RNA Medicine, Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrc.2017.99DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337726PMC
January 2018

A microRNA feedback loop regulates global microRNA abundance during aging.

RNA 2018 02 7;24(2):159-172. Epub 2017 Nov 7.

Department of Molecular, Cellular and Developmental Biology, Yale University, P.O. Box 208103, New Haven, Connecticut 06520, USA.

View Article

Download full-text PDF

Source
http://rnajournal.cshlp.org/lookup/doi/10.1261/rna.062190.11
Publisher Site
http://dx.doi.org/10.1261/rna.062190.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5769744PMC
February 2018

acn-1, a C. elegans homologue of ACE, genetically interacts with the let-7 microRNA and other heterochronic genes.

Cell Cycle 2017 Oct 21;16(19):1800-1809. Epub 2017 Sep 21.

a Department of Molecular, Cellular, and Developmental Biology , Yale University , New Haven , CT , USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/15384101.2017.1344798DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628652PMC
October 2017

MicroRNA therapeutics: towards a new era for the management of cancer and other diseases.

Nat Rev Drug Discov 2017 Mar 17;16(3):203-222. Epub 2017 Feb 17.

Institute for RNA Medicine, Department of Pathology, Beth Israel Deaconess Medical Center Cancer Center, Harvard Medical School, Boston, Massachusetts 02215, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrd.2016.246DOI Listing
March 2017

A serum miRNA profile of human longevity: findings from the Baltimore Longitudinal Study of Aging (BLSA).

Aging (Albany NY) 2016 11;8(11):2971-2987

Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.101106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5191881PMC
November 2016

A role for miR-34 in colon cancer stem cell homeostasis.

Stem Cell Investig 2016 24;3:42. Epub 2016 Aug 24.

Department of Pathology and Institute of RNA Medicine, Beth Israel Deaconess Medical Center Cancer Center, Harvard Medical School, Boston, MA 02215, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21037/sci.2016.08.04DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5014853PMC
September 2016

ADARs Edit MicroRNAs to Promote Leukemic Stem Cell Activity.

Cell Stem Cell 2016 08;19(2):141-142

Institute for RNA Medicine, Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA. Electronic address:

View Article

Download full-text PDF

Source
http://www.cell.com/cell-stem-cell/pdf/S1934-5909(16)30207-7
Web Search
http://linkinghub.elsevier.com/retrieve/pii/S193459091630207
Publisher Site
http://dx.doi.org/10.1016/j.stem.2016.07.012DOI Listing
August 2016

OncomiR or Tumor Suppressor? The Duplicity of MicroRNAs in Cancer.

Cancer Res 2016 07 20;76(13):3666-70. Epub 2016 Jun 20.

Institute for RNA Medicine, Departments of Pathology and Medicine, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, Massachusetts.

View Article

Download full-text PDF

Source
http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
Publisher Site
http://dx.doi.org/10.1158/0008-5472.CAN-16-0359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930690PMC
July 2016

Autofluorescence as a measure of senescence in C. elegans: look to red, not blue or green.

Aging (Albany NY) 2016 05;8(5):889-98

Institute for RNA Medicine, Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.100936DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931842PMC
May 2016

miR-34 activity is modulated through 5'-end phosphorylation in response to DNA damage.

Nat Commun 2016 Mar 21;7:10954. Epub 2016 Mar 21.

Department of Radiation Oncology, David Geffen School of Medicine, Los Angeles, California 90024, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncomms10954DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4802117PMC
March 2016

Cis-acting elements in its 3' UTR mediate post-transcriptional regulation of KRAS.

Oncotarget 2016 Mar;7(11):11770-84

Institute for RNA Medicine, Department of Pathology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/oncotarget.7599DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914247PMC
March 2016

miR-34a Silences c-SRC to Attenuate Tumor Growth in Triple-Negative Breast Cancer.

Cancer Res 2016 Feb 16;76(4):927-39. Epub 2015 Dec 16.

Institute for RNA Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-15-2321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755913PMC
February 2016

The tumor-suppressive and potential therapeutic functions of miR-34a in epithelial carcinomas.

Expert Opin Ther Targets 2016 Jun 11;20(6):737-53. Epub 2015 Dec 11.

b Department of Pathology , BIDMC Cancer Center/Harvard Medical School , Boston , MA , USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1517/14728222.2016.1114102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4922263PMC
June 2016

A novel mechanism of LIN-28 regulation of let-7 microRNA expression revealed by in vivo HITS-CLIP in C. elegans.

RNA 2015 May 24;21(5):985-96. Epub 2015 Mar 24.

Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06405, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1261/rna.045542.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4408804PMC
May 2015

Combinatorial Action of MicroRNAs let-7 and miR-34 Effectively Synergizes with Erlotinib to Suppress Non-small Cell Lung Cancer Cell Proliferation.

Cell Cycle 2015 25;14(13):2171-80. Epub 2015 Feb 25.

a Department of Molecular, Cellular and Developmental Biology; Yale University ; New Haven , CT , USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/15384101.2014.1003008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615025PMC
April 2016

Cancer. Malicious exosomes.

Science 2014 Dec;346(6216):1459-60

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.

View Article

Download full-text PDF

Source
http://www.sciencemag.org/lookup/doi/10.1126/science.aaa4024
Publisher Site
http://dx.doi.org/10.1126/science.aaa4024DOI Listing
December 2014

MicroRNA-mediated regulation of KRAS in cancer.

J Hematol Oncol 2014 Nov 30;7:84. Epub 2014 Nov 30.

Department of Pathology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA, 02215, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13045-014-0084-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263212PMC
November 2014

MicroRNA silencing for cancer therapy targeted to the tumour microenvironment.

Nature 2015 Feb 17;518(7537):107-10. Epub 2014 Nov 17.

Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06511, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature13905DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4367962PMC
February 2015

Expression inactivation of SMARCA4 by microRNAs in lung tumors.

Hum Mol Genet 2015 Mar 29;24(5):1400-9. Epub 2014 Oct 29.

Department of Biochemistry and Molecular Biology, University of Granada, Granada, Spain, Centre for Genomics and Oncological Research (GENYO), Granada, Spain,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/hmg/ddu554DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4321447PMC
March 2015

MicroRNAs mediate dietary-restriction-induced longevity through PHA-4/FOXA and SKN-1/Nrf transcription factors.

Curr Biol 2014 Oct 18;24(19):2238-46. Epub 2014 Sep 18.

Department of Molecular, Cellular and Developmental Biology, Yale University, P.O. Box 208103, New Haven, CT 06520, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cub.2014.08.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4208828PMC
October 2014

Comparative analysis of the transcriptome across distant species.

Nature 2014 Aug;512(7515):445-8

1] Department of Genome Sciences and University of Washington School of Medicine, William H. Foege Building S350D, 1705 Northeast Pacific Street, Box 355065 Seattle, Washington 98195-5065, USA [2].

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature13424DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155737PMC
August 2014

Aberrant regulation and function of microRNAs in cancer.

Curr Biol 2014 Aug;24(16):R762-76

Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cub.2014.06.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4177046PMC
August 2014

RACK-1 regulates let-7 microRNA expression and terminal cell differentiation in Caenorhabditis elegans.

Cell Cycle 2014 28;13(12):1995-2009. Epub 2014 Apr 28.

Graduate Institute of Microbiology; College of Medicine; National Taiwan University; Taipei, Taiwan; Genome and Systems Biology Degree Program; College of Life Science; National Taiwan University; Taipei, Taiwan; Department of Molecular, Cellular, and Developmental Biology; Yale University; New Haven, CT USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4161/cc.29017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111763PMC
January 2015

In this issue of Epigenetics: special focus on non-coding RNAs in epigenetic regulation.

Authors:
Frank J Slack

Epigenetics 2014 Jan;9(1):1-2

Department of Molecular, Cellular and Developmental Biology; Yale University; New Haven, CT USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4161/epi.27579DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928171PMC
January 2014

Extensive sequence variation in the 3' untranslated region of the KRAS gene in lung and ovarian cancer cases.

Cell Cycle 2014 3;13(6):1030-40. Epub 2014 Feb 3.

Department of Molecular, Cellular, and Developmental Biology; Yale University; New Haven, CT USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4161/cc.27941DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984301PMC
October 2014

Autoregulation of lin-4 microRNA transcription by RNA activation (RNAa) in C. elegans.

Cell Cycle 2014 7;13(5):772-81. Epub 2014 Jan 7.

Department of Molecular, Cellular and Developmental Biology; Yale University; New Haven, CT USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4161/cc.27679DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979913PMC
May 2015

MicroRNAs and the cancer phenotype: profiling, signatures and clinical implications.

Genome Med 2013 30;5(12):111. Epub 2013 Dec 30.

Department of Molecular, Cellular and Developmental Biology, Yale University, PO Box 208103, New Haven, CT 06520, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/gm516DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978829PMC
June 2014

Small RNAs deliver a blow to ovarian cancer.

Cancer Discov 2013 Nov;3(11):1220-1

Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/2159-8290.CD-13-0667DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855457PMC
November 2013

RNA-mediated gene activation.

Epigenetics 2014 Jan 1;9(1):27-36. Epub 2013 Nov 1.

Department of Molecular, Cellular and Developmental Biology; Yale University; New Haven, CT USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4161/epi.26942DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928182PMC
January 2014

Generation of Mouse Lung Epithelial Cells.

Bio Protoc 2013 Aug;3(15)

Molecular, Cellular and Developmental Biology Department, Yale University, New Haven, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4880421PMC
http://dx.doi.org/10.21769/bioprotoc.837DOI Listing
August 2013

MicroRNAs circulate around Alzheimer's disease.

Genome Biol 2013 Jul 29;14(7):125. Epub 2013 Jul 29.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/gb4116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053843PMC
July 2013

Joint analysis of expression profiles from multiple cancers improves the identification of microRNA-gene interactions.

Bioinformatics 2013 Sep 14;29(17):2137-45. Epub 2013 Jun 14.

Program in Computational Biology and Bioinformatics, Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06511, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/bioinformatics/btt341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3740623PMC
September 2013

Canonical and non-canonical barriers facing antimiR cancer therapeutics.

Curr Med Chem 2013 ;20(29):3582-93

Department of Biomedical Engineering, Yale University, New Haven, CT 06511, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901840PMC
http://dx.doi.org/10.2174/0929867311320290004DOI Listing
March 2014

MicroRNAs in the ionizing radiation response and in radiotherapy.

Curr Opin Genet Dev 2013 Feb 28;23(1):12-9. Epub 2013 Feb 28.

Department of Molecular, Cellular and Developmental Biology, Yale University, PO Box 208103, New Haven, CT 06520, United States.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617065PMC
http://dx.doi.org/10.1016/j.gde.2013.01.002DOI Listing
February 2013

Arresting the Culprit: Targeted Antagomir Delivery to Sequester Oncogenic miR-221 in HCC.

Mol Ther Nucleic Acids 2012 Mar 20;1:e12. Epub 2012 Mar 20.

Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/mtna.2012.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3381591PMC
March 2012

FGF regulates TGF-β signaling and endothelial-to-mesenchymal transition via control of let-7 miRNA expression.

Cell Rep 2012 Dec 29;2(6):1684-96. Epub 2012 Nov 29.

Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2012.10.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3534912PMC
December 2012

MicroRNAs micromanage themselves.

Circ Res 2012 Nov;111(11):1395-7

Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCRESAHA.112.281014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311873PMC
November 2012

miRNA-34 prevents cancer initiation and progression in a therapeutically resistant K-ras and p53-induced mouse model of lung adenocarcinoma.

Cancer Res 2012 Nov 10;72(21):5576-87. Epub 2012 Sep 10.

Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-12-2001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488137PMC
November 2012

Nanoparticle-based therapy in an in vivo microRNA-155 (miR-155)-dependent mouse model of lymphoma.

Proc Natl Acad Sci U S A 2012 Jun 8;109(26):E1695-704. Epub 2012 Jun 8.

Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06511, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1201516109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387084PMC
June 2012

Biases and errors on allele frequency estimation and disease association tests of next-generation sequencing of pooled samples.

Genet Epidemiol 2012 Sep 6;36(6):549-60. Epub 2012 Jun 6.

Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/gepi.21648DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3477622PMC
September 2012

The duality of oncomiR addiction in the maintenance and treatment of cancer.

Cancer J 2012 May-Jun;18(3):232-7

Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/PPO.0b013e318258b75bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3369429PMC
November 2012

MicroRNAs regulate expression of oncogenes.

Authors:
Frank J Slack

Clin Chem 2013 Jan 23;59(1):325-6. Epub 2012 Apr 23.

Department of Molecular, Cellular and Developmental Biology, Yale University, P.O. Box 208103, New Haven, CT 06520, USA.

View Article

Download full-text PDF

Source
http://www.clinchem.org/content/59/1/325.full.pdf
Web Search
http://www.clinchem.org/cgi/doi/10.1373/clinchem.2011.181016
Publisher Site
http://dx.doi.org/10.1373/clinchem.2011.181016DOI Listing
January 2013

Ageing and the small, non-coding RNA world.

Ageing Res Rev 2013 Jan 6;12(1):429-35. Epub 2012 Apr 6.

Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arr.2012.03.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405179PMC
January 2013

MiR-33 connects cholesterol to the cell cycle.

Cell Cycle 2012 Mar 15;11(6):1060-1. Epub 2012 Mar 15.

Department of Molecular, Cellular and Developmental Biology, Yale University; New Haven, CT, USA.

View Article

Download full-text PDF

Source
http://www.tandfonline.com/doi/full/10.4161/cc.11.6.19786
Publisher Site
http://dx.doi.org/10.4161/cc.11.6.19786DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679221PMC
March 2012

A 'pivotal' new rule for microRNA-mRNA interactions.

Nat Struct Mol Biol 2012 Mar 5;19(3):265-6. Epub 2012 Mar 5.

Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nsmb.2256DOI Listing
March 2012

MicroRNAs and their roles in aging.

J Cell Sci 2012 Jan;125(Pt 1):7-17

Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1242/jcs.099200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3269020PMC
January 2012

Cigarette-Smoke-Induced Dysregulation of MicroRNA Expression and Its Role in Lung Carcinogenesis.

Pulm Med 2012 1;2012:791234. Epub 2011 Dec 1.

Department of Molecular, Cellular and Developmental Biology, Yale University, P.O. Box 208103, New Haven, CT 06520, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2012/791234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3236311PMC
August 2012

KRAS alleles: the LCS6 3'UTR variant and KRAS coding sequence mutations in the NCI-60 panel.

Cell Cycle 2012 Jan 15;11(2):361-6. Epub 2012 Jan 15.

Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4161/cc.11.2.18794DOI Listing
January 2012

Analysis of microRNA expression and function.

Methods Cell Biol 2011 ;106:219-252

Department of Biology, University of California San Diego, La Jolla, California, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/B978-0-12-544172-8.00008-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4314212PMC
March 2012

Epigenetics and genetics. MicroRNAs en route to the clinic: progress in validating and targeting microRNAs for cancer therapy.

Nat Rev Cancer 2011 Nov 24;11(12):849-64. Epub 2011 Nov 24.

Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/nrc3166
Publisher Site
http://dx.doi.org/10.1038/nrc3166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4314215PMC
November 2011

MicroRNAs in mutagenesis, genomic instability, and DNA repair.

Semin Oncol 2011 Dec;38(6):743-51

Department of Hematology, Yale University School of Medicine and the Yale Cancer Center, New Haven, CT, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.seminoncol.2011.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3217196PMC
December 2011

Inhibition of hypoxia-induced miR-155 radiosensitizes hypoxic lung cancer cells.

Cancer Biol Ther 2011 Nov 15;12(10):908-14. Epub 2011 Nov 15.

Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4161/cbt.12.10.17681DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280906PMC
November 2011

KRAS rs61764370 in Epithelial Ovarian Cancer-Letter.

Clin Cancer Res 2011 Oct;17(20):6600; author reply 6601

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1078-0432.CCR-11-1195DOI Listing
October 2011

MicroRNA predictors of longevity in Caenorhabditis elegans.

PLoS Genet 2011 Sep 29;7(9):e1002306. Epub 2011 Sep 29.

Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut, United States of America.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pgen.1002306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3183074PMC
September 2011

Longevity and stress in Caenorhabditis elegans.

Aging (Albany NY) 2011 Aug;3(8):733-53

Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3184976PMC
http://dx.doi.org/10.18632/aging.100367DOI Listing
August 2011

Age-associated changes in expression of small, noncoding RNAs, including microRNAs, in C. elegans.

RNA 2011 Oct 2;17(10):1804-20. Epub 2011 Aug 2.

Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1261/rna.2714411DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185914PMC
October 2011

The POU transcription factor UNC-86 controls the timing and ventral guidance of Caenorhabditis elegans axon growth.

Dev Dyn 2011 Jul 8;240(7):1815-25. Epub 2011 Jun 8.

Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut, USA.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/dvdy.22667
Publisher Site
http://dx.doi.org/10.1002/dvdy.22667DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307343PMC
July 2011

MicroRNA therapeutics in preclinical cancer models.

Lancet Oncol 2011 Apr;12(4):319-21

Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S1470-2045(11)70067-5DOI Listing
April 2011

Systemic delivery of tumor suppressor microRNA mimics using a neutral lipid emulsion inhibits lung tumors in mice.

Mol Ther 2011 Jun 22;19(6):1116-22. Epub 2011 Mar 22.

Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/mt.2011.48DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3129804PMC
June 2011

Integrative analysis of the Caenorhabditis elegans genome by the modENCODE project.

Authors:
Mark B Gerstein Zhi John Lu Eric L Van Nostrand Chao Cheng Bradley I Arshinoff Tao Liu Kevin Y Yip Rebecca Robilotto Andreas Rechtsteiner Kohta Ikegami Pedro Alves Aurelien Chateigner Marc Perry Mitzi Morris Raymond K Auerbach Xin Feng Jing Leng Anne Vielle Wei Niu Kahn Rhrissorrakrai Ashish Agarwal Roger P Alexander Galt Barber Cathleen M Brdlik Jennifer Brennan Jeremy Jean Brouillet Adrian Carr Ming-Sin Cheung Hiram Clawson Sergio Contrino Luke O Dannenberg Abby F Dernburg Arshad Desai Lindsay Dick Andréa C Dosé Jiang Du Thea Egelhofer Sevinc Ercan Ghia Euskirchen Brent Ewing Elise A Feingold Reto Gassmann Peter J Good Phil Green Francois Gullier Michelle Gutwein Mark S Guyer Lukas Habegger Ting Han Jorja G Henikoff Stefan R Henz Angie Hinrichs Heather Holster Tony Hyman A Leo Iniguez Judith Janette Morten Jensen Masaomi Kato W James Kent Ellen Kephart Vishal Khivansara Ekta Khurana John K Kim Paulina Kolasinska-Zwierz Eric C Lai Isabel Latorre Amber Leahey Suzanna Lewis Paul Lloyd Lucas Lochovsky Rebecca F Lowdon Yaniv Lubling Rachel Lyne Michael MacCoss Sebastian D Mackowiak Marco Mangone Sheldon McKay Desirea Mecenas Gennifer Merrihew David M Miller Andrew Muroyama John I Murray Siew-Loon Ooi Hoang Pham Taryn Phippen Elicia A Preston Nikolaus Rajewsky Gunnar Rätsch Heidi Rosenbaum Joel Rozowsky Kim Rutherford Peter Ruzanov Mihail Sarov Rajkumar Sasidharan Andrea Sboner Paul Scheid Eran Segal Hyunjin Shin Chong Shou Frank J Slack Cindie Slightam Richard Smith William C Spencer E O Stinson Scott Taing Teruaki Takasaki Dionne Vafeados Ksenia Voronina Guilin Wang Nicole L Washington Christina M Whittle Beijing Wu Koon-Kiu Yan Georg Zeller Zheng Zha Mei Zhong Xingliang Zhou Julie Ahringer Susan Strome Kristin C Gunsalus Gos Micklem X Shirley Liu Valerie Reinke Stuart K Kim LaDeana W Hillier Steven Henikoff Fabio Piano Michael Snyder Lincoln Stein Jason D Lieb Robert H Waterston

Science 2010 Dec 22;330(6012):1775-87. Epub 2010 Dec 22.

Program in Computational Biology and Bioinformatics, Yale University, Bass 432, 266 Whitney Avenue, New Haven, CT 06520, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.1196914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142569PMC
December 2010

MicroRNAs both promote and antagonize longevity in C. elegans.

Curr Biol 2010 Dec 2;20(24):2159-68. Epub 2010 Dec 2.

Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06511 USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cub.2010.11.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3023310PMC
December 2010

kin-19/casein kinase Iα has dual functions in regulating asymmetric division and terminal differentiation in C. elegans epidermal stem cells.

Cell Cycle 2010 Dec 1;9(23):4748-65. Epub 2010 Dec 1.

Department of Biological Sciences, Virginia Tech University, Blacksburg, VA, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048040PMC
http://dx.doi.org/10.4161/cc.9.23.14092DOI Listing
December 2010

A developmental timing switch promotes axon outgrowth independent of known guidance receptors.

PLoS Genet 2010 Aug 5;6(8). Epub 2010 Aug 5.

Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pgen.1001054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2916846PMC
August 2010

OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma.

Nature 2010 Sep 8;467(7311):86-90. Epub 2010 Aug 8.

Department of Molecular, Cellular and Developmental Biology, Yale University, PO Box 208103, New Haven, Connecticut 06520, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature09284DOI Listing
September 2010