Frank J M van Kuppeveld

Frank J M van Kuppeveld

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Frank J M van Kuppeveld

Publications by authors named "Frank J M van Kuppeveld"

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Intra-host emergence of an enterovirus A71 variant with enhanced PSGL1 usage and neurovirulence.

Emerg Microbes Infect 2019 ;8(1):1076-1085

a KU Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy , Leuven , Belgium.

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http://dx.doi.org/10.1080/22221751.2019.1644142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6711088PMC
November 2019

Fluoxetine Inhibits Enterovirus Replication by Targeting the Viral 2C Protein in a Stereospecific Manner.

ACS Infect Dis 2019 09 31;5(9):1609-1623. Epub 2019 Jul 31.

Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine , Utrecht University , Utrecht 3584CL , The Netherlands.

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http://dx.doi.org/10.1021/acsinfecdis.9b00179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6747591PMC
September 2019

No evidence for viral small RNA production and antiviral function of Argonaute 2 in human cells.

Sci Rep 2019 Sep 24;9(1):13752. Epub 2019 Sep 24.

Department of Medical Microbiology, Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1038/s41598-019-50287-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6760161PMC
September 2019

Identification of the Cell-Surface Protease ADAM9 as an Entry Factor for Encephalomyocarditis Virus.

mBio 2019 08 13;10(4). Epub 2019 Aug 13.

Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands

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http://mbio.asm.org/lookup/doi/10.1128/mBio.01780-19
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http://dx.doi.org/10.1128/mBio.01780-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6692517PMC
August 2019

Lipid Droplets Grease Enterovirus Replication.

Cell Host Microbe 2019 08;26(2):149-151

Division of Virology, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2019.07.017DOI Listing
August 2019

Bypassing pan-enterovirus host factor PLA2G16.

Nat Commun 2019 07 18;10(1):3171. Epub 2019 Jul 18.

Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, 3584 CL, Utrecht, The Netherlands.

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http://dx.doi.org/10.1038/s41467-019-11256-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639302PMC
July 2019

Origins of Enterovirus Replication Organelles Established by Whole-Cell Electron Microscopy.

mBio 2019 06 11;10(3). Epub 2019 Jun 11.

Section Electron Microscopy, Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands

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http://dx.doi.org/10.1128/mBio.00951-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561026PMC
June 2019

Essential Role of Enterovirus 2A Protease in Counteracting Stress Granule Formation and the Induction of Type I Interferon.

J Virol 2019 05 1;93(10). Epub 2019 May 1.

Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands

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http://dx.doi.org/10.1128/JVI.00222-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6498061PMC
May 2019

Small molecule ISRIB suppresses the integrated stress response within a defined window of activation.

Proc Natl Acad Sci U S A 2019 02 23;116(6):2097-2102. Epub 2019 Jan 23.

Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, 3584 CL Utrecht, The Netherlands;

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http://dx.doi.org/10.1073/pnas.1815767116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369741PMC
February 2019

Human coronaviruses OC43 and HKU1 bind to 9--acetylated sialic acids via a conserved receptor-binding site in spike protein domain A.

Proc Natl Acad Sci U S A 2019 02 24;116(7):2681-2690. Epub 2019 Jan 24.

Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, 3584 CH Utrecht, The Netherlands;

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http://dx.doi.org/10.1073/pnas.1809667116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377473PMC
February 2019

Foot-and-Mouth Disease Virus Leader Protease Cleaves G3BP1 and G3BP2 and Inhibits Stress Granule Formation.

J Virol 2019 01 4;93(2). Epub 2019 Jan 4.

Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, The Netherlands

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http://dx.doi.org/10.1128/JVI.00922-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321903PMC
January 2019

Molecular basis for the acid-initiated uncoating of human enterovirus D68.

Proc Natl Acad Sci U S A 2018 12 10;115(52):E12209-E12217. Epub 2018 Dec 10.

Department of Biological Sciences, Purdue University, West Lafayette, IN 47907;

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http://dx.doi.org/10.1073/pnas.1803347115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310856PMC
December 2018

Substrate Binding by the Second Sialic Acid-Binding Site of Influenza A Virus N1 Neuraminidase Contributes to Enzymatic Activity.

J Virol 2018 10 26;92(20). Epub 2018 Sep 26.

Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands

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http://jvi.asm.org/lookup/doi/10.1128/JVI.01243-18
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http://dx.doi.org/10.1128/JVI.01243-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158415PMC
October 2018

Posaconazole inhibits dengue virus replication by targeting oxysterol-binding protein.

Antiviral Res 2018 09 3;157:68-79. Epub 2018 Jul 3.

Department of Medical Microbiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands; Radboudumc Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.antiviral.2018.06.017DOI Listing
September 2018

Structure-activity relationship study of itraconazole, a broad-range inhibitor of picornavirus replication that targets oxysterol-binding protein (OSBP).

Antiviral Res 2018 08 26;156:55-63. Epub 2018 May 26.

Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, 3584CL Utrecht, the Netherlands. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01663542183002
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http://dx.doi.org/10.1016/j.antiviral.2018.05.010DOI Listing
August 2018

The life cycle of non-polio enteroviruses and how to target it.

Nat Rev Microbiol 2018 06;16(6):368-381

Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands.

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http://dx.doi.org/10.1038/s41579-018-0005-4DOI Listing
June 2018

Publisher Correction: The life cycle of non-polio enteroviruses and how to target it.

Nat Rev Microbiol 2018 Jun;16(6):391

Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands.

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http://dx.doi.org/10.1038/s41579-018-0022-3DOI Listing
June 2018

Broad receptor engagement of an emerging global coronavirus may potentiate its diverse cross-species transmissibility.

Proc Natl Acad Sci U S A 2018 05 14;115(22):E5135-E5143. Epub 2018 May 14.

Virology Division, Department of Infectious Diseases & Immunology, Faculty of Veterinary Medicine, Utrecht University, 3584 CL Utrecht, The Netherlands;

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http://dx.doi.org/10.1073/pnas.1802879115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984533PMC
May 2018

Irreversible inactivation of ISG15 by a viral leader protease enables alternative infection detection strategies.

Proc Natl Acad Sci U S A 2018 03 20;115(10):2371-2376. Epub 2018 Feb 20.

Protein and Nucleic Acid Chemistry Division, Medical Research Council Laboratory of Molecular Biology, CB2 0QH Cambridge, United Kingdom;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1710617115
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http://dx.doi.org/10.1073/pnas.1710617115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877979PMC
March 2018

Modulation of proteolytic polyprotein processing by coxsackievirus mutants resistant to inhibitors targeting phosphatidylinositol-4-kinase IIIβ or oxysterol binding protein.

Antiviral Res 2017 Nov 9;147:86-90. Epub 2017 Oct 9.

Department of Infectious Diseases & Immunology, Virology Division, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.antiviral.2017.10.006DOI Listing
November 2017

Deletion of Cytoplasmic Double-Stranded RNA Sensors Does Not Uncover Viral Small Interfering RNA Production in Human Cells.

mSphere 2017 Jul-Aug;2(4). Epub 2017 Aug 16.

Department of Medical Microbiology, Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1128/mSphere.00333-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557678PMC
August 2017

Aminopeptidase N is not required for porcine epidemic diarrhea virus cell entry.

Virus Res 2017 05 28;235:6-13. Epub 2017 Mar 28.

Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.virusres.2017.03.018DOI Listing
May 2017

Uncovering oxysterol-binding protein (OSBP) as a target of the anti-enteroviral compound TTP-8307.

Antiviral Res 2017 04 11;140:37-44. Epub 2017 Jan 11.

Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.antiviral.2017.01.008DOI Listing
April 2017

Betacoronavirus Adaptation to Humans Involved Progressive Loss of Hemagglutinin-Esterase Lectin Activity.

Cell Host Microbe 2017 Mar;21(3):356-366

Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, 3584 CH Utrecht, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2017.02.008DOI Listing
March 2017

Cellular entry of the porcine epidemic diarrhea virus.

Virus Res 2016 12 15;226:117-127. Epub 2016 Jun 15.

Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.virusres.2016.05.031DOI Listing
December 2016

Tyrphostin AG1478 Inhibits Encephalomyocarditis Virus and Hepatitis C Virus by Targeting Phosphatidylinositol 4-Kinase IIIα.

Antimicrob Agents Chemother 2016 10 23;60(10):6402-6. Epub 2016 Sep 23.

Department of Infectious Diseases & Immunology, Virology Division, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands

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http://dx.doi.org/10.1128/AAC.01331-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5038282PMC
October 2016

Identification of Residues That Affect Oligomerization and/or Enzymatic Activity of Influenza Virus H5N1 Neuraminidase Proteins.

J Virol 2016 10 29;90(20):9457-70. Epub 2016 Sep 29.

Virology Division, Department of Infectious Diseases & Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands

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http://dx.doi.org/10.1128/JVI.01346-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5044851PMC
October 2016

Middle East Respiratory Coronavirus Accessory Protein 4a Inhibits PKR-Mediated Antiviral Stress Responses.

PLoS Pathog 2016 Oct 26;12(10):e1005982. Epub 2016 Oct 26.

Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.

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http://dx.doi.org/10.1371/journal.ppat.1005982DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081173PMC
October 2016

Building Viral Replication Organelles: Close Encounters of the Membrane Types.

PLoS Pathog 2016 10 27;12(10):e1005912. Epub 2016 Oct 27.

Division of Virology, Department of Infectious Diseases & Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.

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http://dx.doi.org/10.1371/journal.ppat.1005912DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082816PMC
October 2016

Structure and Genome Release Mechanism of the Human Cardiovirus Saffold Virus 3.

J Virol 2016 09 12;90(17):7628-39. Epub 2016 Aug 12.

Central European Institute of Technology, Masaryk University, Brno, Czech Republic

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http://dx.doi.org/10.1128/JVI.00746-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4988150PMC
September 2016

Fat(al) attraction: Picornaviruses Usurp Lipid Transfer at Membrane Contact Sites to Create Replication Organelles.

Trends Microbiol 2016 07 22;24(7):535-546. Epub 2016 Mar 22.

Department of Infectious Diseases & Immunology, Virology Division, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.tim.2016.02.017DOI Listing
July 2016

Characterization of Epitope-Specific Anti-Respiratory Syncytial Virus (Anti-RSV) Antibody Responses after Natural Infection and after Vaccination with Formalin-Inactivated RSV.

J Virol 2016 07 10;90(13):5965-5977. Epub 2016 Jun 10.

Virology Division, Department of Infectious Diseases & Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands

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http://dx.doi.org/10.1128/JVI.00235-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4907225PMC
July 2016

Neurotropism of Saffold virus in a mouse model.

J Gen Virol 2016 06 9;97(6):1350-1355. Epub 2016 Mar 9.

de Duve Institute, Université Catholique de Louvain, VIRO B1.74.07, 74 Avenue Hippocrate, Brussels B-1200, Belgium.

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http://dx.doi.org/10.1099/jgv.0.000452DOI Listing
June 2016

Enterovirus-infected β-cells induce distinct response patterns in BDCA1+ and BDCA3+ human dendritic cells.

PLoS One 2015 25;10(3):e0121670. Epub 2015 Mar 25.

Department of Tumor Immunology, Radboud university medical center, Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0121670PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4373773PMC
March 2016

Enterovirus D68 receptor requirements unveiled by haploid genetics.

Proc Natl Acad Sci U S A 2016 Feb 19;113(5):1399-404. Epub 2016 Jan 19.

Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, 3584 CL, Utrecht, The Netherlands;

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http://dx.doi.org/10.1073/pnas.1524498113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747778PMC
February 2016

Antiviral Activity of Broad-Spectrum and Enterovirus-Specific Inhibitors against Clinical Isolates of Enterovirus D68.

Antimicrob Agents Chemother 2015 Dec 14;59(12):7782-5. Epub 2015 Sep 14.

KU Leuven - University of Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, Leuven, Belgium.

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http://dx.doi.org/10.1128/AAC.01375-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649165PMC
December 2015

Synergistic antiviral activity of gemcitabine and ribavirin against enteroviruses.

Antiviral Res 2015 Dec 23;124:1-10. Epub 2015 Oct 23.

Incurable Diseases Therapeutics Research Center, Korea Research Institute of Bioscience & Biotechnology, Cheongju, South Korea; Department of Biomolecular Science, Korea University of Science and Technology, Daejeon, South Korea. Electronic address:

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http://dx.doi.org/10.1016/j.antiviral.2015.10.011DOI Listing
December 2015

Knockout of cGAS and STING Rescues Virus Infection of Plasmid DNA-Transfected Cells.

J Virol 2015 Nov 26;89(21):11169-73. Epub 2015 Aug 26.

Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands

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http://jvi.asm.org/content/89/21/11169.full.pdf
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http://jvi.asm.org/lookup/doi/10.1128/JVI.01781-15
Publisher Site
http://dx.doi.org/10.1128/JVI.01781-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621133PMC
November 2015

Sialic acid-dependent cell entry of human enterovirus D68.

Nat Commun 2015 Nov 13;6:8865. Epub 2015 Nov 13.

Department of Biological Sciences, Hockmeyer Hall of Structural Biology, 240 South Martin Jischke Drive, Purdue University, West Lafayette, Indiana 47907, USA.

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http://www.nature.com/articles/ncomms9865
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http://dx.doi.org/10.1038/ncomms9865DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4660200PMC
November 2015

Integrative Genomics-Based Discovery of Novel Regulators of the Innate Antiviral Response.

PLoS Comput Biol 2015 Oct 20;11(10):e1004553. Epub 2015 Oct 20.

Centre for Molecular and Biomolecular Informatics, Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1371/journal.pcbi.1004553DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618338PMC
October 2015

Cholesterol shuttling is important for RNA replication of coxsackievirus B3 and encephalomyocarditis virus.

Cell Microbiol 2015 Aug 10;17(8):1144-56. Epub 2015 Mar 10.

Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.

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http://dx.doi.org/10.1111/cmi.12425DOI Listing
August 2015

A Single Point Mutation Creating a Furin Cleavage Site in the Spike Protein Renders Porcine Epidemic Diarrhea Coronavirus Trypsin Independent for Cell Entry and Fusion.

J Virol 2015 Aug 13;89(15):8077-81. Epub 2015 May 13.

Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands

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http://dx.doi.org/10.1128/JVI.00356-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505673PMC
August 2015

Replication and Inhibitors of Enteroviruses and Parechoviruses.

Viruses 2015 Aug 10;7(8):4529-62. Epub 2015 Aug 10.

Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, Utrecht 3584 CL, The Netherlands.

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http://www.mdpi.com/1999-4915/7/8/2832
Publisher Site
http://dx.doi.org/10.3390/v7082832DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4576193PMC
August 2015

Coxsackievirus cloverleaf RNA containing a 5' triphosphate triggers an antiviral response via RIG-I activation.

PLoS One 2014 23;9(4):e95927. Epub 2014 Apr 23.

Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, University of Utrecht, Utrecht, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0095927PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3997492PMC
June 2015

Broad-range inhibition of enterovirus replication by OSW-1, a natural compound targeting OSBP.

Antiviral Res 2015 May 6;117:110-4. Epub 2015 Mar 6.

Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.antiviral.2015.02.013DOI Listing
May 2015

Targeting of the hydrophobic metabolome by pathogens.

Traffic 2015 May;16(5):439-60

Department of Biochemistry and Cell Biology, Faculty of Veterinary Medicine & Institute of Biomembranes, Utrecht University, Yalelaan 2, 3584 CM, Utrecht, The Netherlands.

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http://dx.doi.org/10.1111/tra.12280DOI Listing
May 2015

The RNA template channel of the RNA-dependent RNA polymerase as a target for development of antiviral therapy of multiple genera within a virus family.

PLoS Pathog 2015 Mar 23;11(3):e1004733. Epub 2015 Mar 23.

Department of Medical Microbiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands; Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.

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http://dx.doi.org/10.1371/journal.ppat.1004733DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4370873PMC
March 2015

GBF1- and ACBD3-independent recruitment of PI4KIIIβ to replication sites by rhinovirus 3A proteins.

J Virol 2015 Feb 19;89(3):1913-8. Epub 2014 Nov 19.

Department of Medical Microbiology, Radboud Institute for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands Department of Infectious Diseases & Immunology, Virology Division, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.

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http://dx.doi.org/10.1128/JVI.02830-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4300732PMC
February 2015

Itraconazole inhibits enterovirus replication by targeting the oxysterol-binding protein.

Cell Rep 2015 Feb 29;10(4):600-15. Epub 2015 Jan 29.

Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, 3584CL Utrecht, the Netherlands; Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, 6525GA Nijmegen, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.12.054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383725PMC
February 2015

Rhinovirus uses a phosphatidylinositol 4-phosphate/cholesterol counter-current for the formation of replication compartments at the ER-Golgi interface.

Cell Host Microbe 2014 Nov 12;16(5):677-90. Epub 2014 Nov 12.

Institute of Molecular Life Sciences, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2014.10.003DOI Listing
November 2014

Induction and suppression of innate antiviral responses by picornaviruses.

Cytokine Growth Factor Rev 2014 Oct 18;25(5):577-85. Epub 2014 Jul 18.

Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, University of Utrecht, 3584CL Utrecht, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.cytogfr.2014.07.003DOI Listing
October 2014

Saffold cardiovirus and multiple sclerosis: no evidence for an association.

Ann Clin Transl Neurol 2014 Aug 23;1(8):618-21. Epub 2014 Jul 23.

Department of Medical Microbiology, Radboud University Medical Centre 6500 HB, Nijmegen, The Netherlands ; Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University Utrecht, The Netherlands.

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http://dx.doi.org/10.1002/acn3.82DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184563PMC
August 2014

Proteolytic activation of the porcine epidemic diarrhea coronavirus spike fusion protein by trypsin in cell culture.

J Virol 2014 Jul 7;88(14):7952-61. Epub 2014 May 7.

Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands

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http://dx.doi.org/10.1128/JVI.00297-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4097775PMC
July 2014

Identification and characterization of a proteolytically primed form of the murine coronavirus spike proteins after fusion with the target cell.

J Virol 2014 May 19;88(9):4943-52. Epub 2014 Feb 19.

Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.

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http://jvi.asm.org/cgi/doi/10.1128/JVI.03451-13
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http://dx.doi.org/10.1128/JVI.03451-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3993802PMC
May 2014

Manipulation of the porcine epidemic diarrhea virus genome using targeted RNA recombination.

PLoS One 2013 2;8(8):e69997. Epub 2013 Aug 2.

Institute of Animal Science and Veterinary Medicine, Shanghai Academy of Agricultural Sciences, Shanghai, PR China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0069997PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732256PMC
April 2014

Binding of glutathione to enterovirus capsids is essential for virion morphogenesis.

PLoS Pathog 2014 Apr 10;10(4):e1004039. Epub 2014 Apr 10.

Department of Microbiology and Immunology, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1371/journal.ppat.1004039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983060PMC
April 2014

Fitness and virulence of a coxsackievirus mutant that can circumnavigate the need for phosphatidylinositol 4-kinase class III beta.

J Virol 2014 Mar 26;88(5):3048-51. Epub 2013 Dec 26.

Department of Infectious Diseases & Immunology, Virology Division, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.

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http://dx.doi.org/10.1128/JVI.03177-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958056PMC
March 2014

Enterovirus 2Apro targets MDA5 and MAVS in infected cells.

J Virol 2014 Mar 3;88(6):3369-78. Epub 2014 Jan 3.

Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.

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http://dx.doi.org/10.1128/JVI.02712-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3957915PMC
March 2014

Application of a cell-based protease assay for testing inhibitors of picornavirus 3C proteases.

Antiviral Res 2014 Mar 4;103:17-24. Epub 2014 Jan 4.

Department of Medical Microbiology, Nijmegen Centre for Molecular Life Sciences & Nijmegen Institute for Infection, Inflammation and Immunity, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands; Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.antiviral.2013.12.012DOI Listing
March 2014

Modification of picornavirus genomic RNA using 'click' chemistry shows that unlinking of the VPg peptide is dispensable for translation and replication of the incoming viral RNA.

Nucleic Acids Res 2014 Feb 15;42(4):2473-82. Epub 2013 Nov 15.

Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, 3584 CL, The Netherlands, Institute for Molecules and Materials, Radboud University Nijmegen, Nijmegen, 6500 HB, The Netherlands, Department of Microbiology and Molecular Genetics, School of Medicine, University of California, Irvine, CA 92697, USA and Leiden Institute of Chemistry, Leiden University, Bioorganic Synthesis Leiden, 2300 RA, The Netherlands.

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http://dx.doi.org/10.1093/nar/gkt1162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936719PMC
February 2014

Differential susceptibility and response of primary human myeloid BDCA1(+) dendritic cells to infection with different Enteroviruses.

PLoS One 2013 24;8(4):e62502. Epub 2013 Apr 24.

Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences & Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0062502PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634769PMC
December 2013

Rhinovirus-induced calcium flux triggers NLRP3 and NLRC5 activation in bronchial cells.

Am J Respir Cell Mol Biol 2013 Dec;49(6):923-34

1 Cardiff University, Institute of Infection and Immunity, Department of Child Health, School of Medicine, University Hospital of Wales, Heath Park, Cardiff, Wales; and.

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http://dx.doi.org/10.1165/rcmb.2013-0032OCDOI Listing
December 2013

Cholesterol: fa(s)t-food for enterovirus genome replication.

Trends Microbiol 2013 Nov 6;21(11):560-1. Epub 2013 Oct 6.

Department of Infectious Diseases and Immunology, Virology Division, Faculty of Veterinary Medicine, Utrecht University, 3584 CL, Utrecht, The Netherlands.

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http://dx.doi.org/10.1016/j.tim.2013.09.007DOI Listing
November 2013

Identification of a new dengue virus inhibitor that targets the viral NS4B protein and restricts genomic RNA replication.

Antiviral Res 2013 Aug 2;99(2):165-71. Epub 2013 Jun 2.

Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Nijmegen Institute for Infection, Inflammation and Immunity, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.antiviral.2013.05.011DOI Listing
August 2013

The receptor binding domain of the new Middle East respiratory syndrome coronavirus maps to a 231-residue region in the spike protein that efficiently elicits neutralizing antibodies.

J Virol 2013 Aug 19;87(16):9379-83. Epub 2013 Jun 19.

Department of Infectious Diseases and Immunology, Virology Division, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.

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http://dx.doi.org/10.1128/JVI.01277-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3754068PMC
August 2013

Synthesis and biological properties of novel brefeldin A analogues.

J Med Chem 2013 Jul 8;56(14):5872-84. Epub 2013 Jul 8.

Institute of Organic Chemistry, University of Heidelberg , Im Neuenheimer Feld 270, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1021/jm400615gDOI Listing
July 2013

Selective serotonin reuptake inhibitor fluoxetine inhibits replication of human enteroviruses B and D by targeting viral protein 2C.

Antimicrob Agents Chemother 2013 Apr 18;57(4):1952-6. Epub 2013 Jan 18.

Department of Infectious Diseases and Immunology, Virology Division, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.

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http://dx.doi.org/10.1128/AAC.02084-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3623316PMC
April 2013

(+)RNA viruses rewire cellular pathways to build replication organelles.

Curr Opin Virol 2012 Dec 1;2(6):740-7. Epub 2012 Oct 1.

Virginia-Maryland College of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA.

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http://dx.doi.org/10.1016/j.coviro.2012.09.006DOI Listing
December 2012

Coxsackievirus mutants that can bypass host factor PI4KIIIβ and the need for high levels of PI4P lipids for replication.

Cell Res 2012 Nov 4;22(11):1576-92. Epub 2012 Sep 4.

Department of Medical Microbiology, Virology Section, Nijmegen Centre for Molecular Life Sciences & Nijmegen Institute for Infection, Inflammation and Immunity, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands;

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http://dx.doi.org/10.1038/cr.2012.129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494396PMC
November 2012

MDA5 detects the double-stranded RNA replicative form in picornavirus-infected cells.

Cell Rep 2012 Nov 8;2(5):1187-96. Epub 2012 Nov 8.

Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, PO Box 9101, 6500 HB, The Netherlands.

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http://dx.doi.org/10.1016/j.celrep.2012.10.005DOI Listing
November 2012

Cytokine and chemokine production by human pancreatic islets upon enterovirus infection.

Diabetes 2012 Aug 17;61(8):2030-6. Epub 2012 May 17.

1Department of Tumor Immunology, Nijmegen Center for Molecular Life Sciences, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.2337/db11-1547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402326PMC
August 2012

Unusual loop-sequence flexibility of the proximal RNA replication element in EMCV.

PLoS One 2011 14;6(9):e24818. Epub 2011 Sep 14.

Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0024818PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173479PMC
February 2012