Publications by authors named "Frank J Gonzalez"

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Metabolic Profiling of the Novel Hypoxia-Inducible Factor 2 Inhibitor PT2385 In Vivo and In Vitro.
Drug Metab Dispos 2018 Apr 23;46(4):336-345. Epub 2018 Jan 23.
Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (C.X., X.G., D.S., Y.Z., K.W.K., F.J.G.); and Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan, Shanxi, People's Republic of China (X.G., X.Q.)

Distinct role of nuclear receptor corepressor 1 regulated de novo fatty acids synthesis in liver regeneration and hepatocarcinogenesis in mice.
Hepatology 2018 Mar 26;67(3):1071-1087. Epub 2018 Jan 26.
The International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China.


Chemical inhibition and stable knock-down of efflux transporters leads to reduced glucuronidation of wushanicaritin in UGT1A1-overexpressing HeLa cells: the role of breast cancer resistance protein (BCRP) and multidrug resistance-associated proteins (MRPs) in the excretion of glucuronides.
Food Funct 2018 Mar 10;9(3):1410-1423. Epub 2018 Jan 10.
College of Pharmacy, Jinan University, Guangzhou 510632, P. R. China. and Guangdong Provincial Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, P. R. China. and Integrated Chinese and Western Medicine Postdoctoral Research Station, Jinan University, Guangzhou 510632, P. R. China and Guangzhou Research and Creativity Biotechnology Co. Ltd, Guangzhou, 510663, P. R. China.

Corrigendum to "Metabolic adaptation to intermittent fasting is independent of peroxisome proliferator-activated receptor alpha" [Mol Metab 7 (2018) 80-89].
Mol Metab 2018 Mar 2;9:217-219. Epub 2018 Feb 2.
Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:

Metabolic profiling of corylin in vivo and in vitro.
J Pharm Biomed Anal 2018 Mar 26;155:157-168. Epub 2018 Mar 26.
College of Pharmacy, Jinan University, Guangzhou 510632, PR China; Guangdong Provincial Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, PR China; Integrated Chinese and Western Medicine Postdoctoral research station, Jinan University, Guangzhou 510632, PR China. Electronic address:


Growth arrest and DNA damage-inducible 45α protects against nonalcoholic steatohepatitis induced by methionine- and choline-deficient diet.
Biochim Biophys Acta 2017 Dec 24;1863(12):3170-3182. Epub 2017 Aug 24.
Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States. Electronic address:

Pharmacophore-based virtual screening of catechol-o-methyltransferase (COMT) inhibitors to combat Alzheimer's disease.
J Biomol Struct Dyn 2017 Dec 27:1-20. Epub 2017 Dec 27.
a Department of Botany, Bioinformatics and Climate Change Impacts Management , University School of Sciences, Gujarat University , Ahmedabad 380 009 , Gujarat , India.

Activation of intestinal hypoxia-inducible factor 2α during obesity contributes to hepatic steatosis.
Nat Med 2017 Nov 9;23(11):1298-1308. Epub 2017 Oct 9.
Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

Inhibitory effects of fifteen phthalate esters in human cDNA-expressed UDP-glucuronosyltransferase supersomes.
Chemosphere 2017 Oct 19;185:983-990. Epub 2017 Jul 19.
Department of Toxicology, School of Public Health, Tianjin Medical University, 22 Qixiangtai Road, Heping District, Tianjin, China. Electronic address:

Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota.
Cell Metab 2017 Oct 14;26(4):672-685.e4. Epub 2017 Sep 14.
Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:

Editor's Highlight: PPARβ/δ and PPARγ Inhibit Melanoma Tumorigenicity by Modulating Inflammation and Apoptosis.
Toxicol Sci 2017 Oct;159(2):436-448
Department of Veterinary and Biomedical Sciences, The Center of Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, Pennsylvania 16802.


Orthogonal Comparison of GC-MS and H NMR Spectroscopy for Short Chain Fatty Acid Quantitation.
Anal Chem 2017 Aug 12;89(15):7900-7906. Epub 2017 Jul 12.
Center for Molecular Toxicology and Carcinogenesis, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University , University Park, Pennsylvania 16802, United States.

Vascular smooth muscle cell peroxisome proliferator-activated receptor γ protects against endothelin-1-induced oxidative stress and inflammation.
J Hypertens 2017 Jul;35(7):1390-1401
aHypertension and Vascular Research Unit, Lady Davis Institute for Medical Research bDepartment of Medicine, Sir Mortimer B. Davis-Jewish General Hospital, McGill University, Montreal, Quebec, Canada cDepartment of Clinical Medicine, State University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil dDepartment of Pharmacology, Max-Planck-Institute for Heart and Lung Research, Bad Nauheim, Germany eLaboratory of Metabolism, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA *Noureddine Idris-Khodja and Sofiane Ouerd contributed equally to the article.

Farnesoid X Receptor Signaling Shapes the Gut Microbiota and Controls Hepatic Lipid Metabolism.
mSystems 2016 Sep-Oct;1(5). Epub 2016 Oct 11.
Center for Molecular Toxicology and Carcinogenesis, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, Pennsylvania, USA.

Role of the lipid-regulated NF-κB/IL-6/STAT3 axis in alpha-naphthyl isothiocyanate-induced liver injury.
Arch Toxicol 2017 May 16;91(5):2235-2244. Epub 2016 Nov 16.
Laboratory of Metabolism, Center for Cancer Research, National Institutes of Health, Building 37, Room 3106, Bethesda, MD, 20892, USA.

Peroxisome proliferator-activated receptor-β/δ inhibits human neuroblastoma cell tumorigenesis by inducing p53- and SOX2-mediated cell differentiation.
Mol Carcinog 2017 May 13;56(5):1472-1483. Epub 2017 Jan 13.
Department of Veterinary and Biomedical Sciences and The Center of Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, Pennsylvania.


Age-dependent PPARα activation induces hepatic sulfatide accumulation in transgenic mice carrying the hepatitis C virus core gene.
Glycoconj J 2016 Dec 18;33(6):927-936. Epub 2016 Jun 18.
Department of Metabolic Regulation, Shinshu University Graduate School of Medicine, Matsumoto, 390-8621, Japan.

The antiandrogen flutamide is a novel aryl hydrocarbon receptor ligand that disrupts bile acid homeostasis in mice through induction of Abcc4.
Biochem Pharmacol 2016 Nov 26;119:93-104. Epub 2016 Aug 26.
Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:

Regulation of Cytochrome P450 2B10 (CYP2B10) Expression in Liver by Peroxisome Proliferator-activated Receptor-β/δ Modulation of SP1 Promoter Occupancy.
J Biol Chem 2016 Nov 20;291(48):25255-25263. Epub 2016 Oct 20.
From the Department of Veterinary and Biomedical Sciences and the Center of Molecular Toxicology and Carcinogenesis, Pennsylvania State University, University Park, Pennsylvania 16802,

Phosphorylation of Farnesoid X Receptor at Serine 154 Links Ligand Activation With Degradation.
Mol Endocrinol 2016 Oct 29;30(10):1070-1080. Epub 2016 Aug 29.
Pharmacogenetics Section (T.H., S.A., T.S., M.N.), Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709; and Laboratory of Metabolism (S.T., F.J.G.), Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892.


Metabolomics reveals mycoplasma contamination interferes with the metabolism of PANC-1 cells.
Anal Bioanal Chem 2016 Jun 13;408(16):4267-73. Epub 2016 Apr 13.
School of Pharmaceutical Sciences, Sun Yat-sen University, 132# Waihuandong Rd, University City of Guangzhou, Guangzhou, 510006, China.

6β-Hydroxytestosterone, a Cytochrome P450 1B1-Testosterone-Metabolite, Mediates Angiotensin II-Induced Renal Dysfunction in Male Mice.
Hypertension 2016 May 29;67(5):916-26. Epub 2016 Feb 29.
From the Department of Pharmacology (A.K.P., S.T., M.K., K.U.M.) and Department of Medicine and Microbiology, Immunology and Biochemistry (D.D.B.), College of Medicine, University of Tennessee Health Science Center, Memphis; Veterans Affairs Medical Center, Memphis, TN (D.D.B.); Tulane Hypertension and Renal Center of Excellence, Department of Physiology, School of Medicine, Tulane University, New Orleans, LA (A.K., D.S.A.M., L.G.N.); and Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, Bethesda, MD (F.J.G.).

Glycyrrhizin Protects against Acetaminophen-Induced Acute Liver Injury via Alleviating Tumor Necrosis Factor α-Mediated Apoptosis.
Drug Metab Dispos 2016 May 10;44(5):720-31. Epub 2016 Mar 10.
State Key Laboratory of Natural Medicines, Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, Jiangsu, People's Republic of China (Ti.Y., H.W., M.Z., Yi.C., X.C., J.Z., Yu.C., F.L., Y.W., G.W., H.H.); Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (Ti.Y., To.Y., K.W.K., C.X., C.N.B., F.J.G.)

Serum miRNAs as predictive and preventive biomarker for pre-clinical hepatocellular carcinoma.
Cancer Lett 2016 Apr 2;373(2):234-40. Epub 2016 Feb 2.
International Co-operation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Institute, Second Military Medical University, Shanghai 200438, China; National Center for Liver Cancer, Shanghai, China; National Laboratory for Oncogenes and Related Genes, Cancer Institute, RenJi Hospital, Shanghai Jiao Tong University, Shanghai 200441, China. Electronic address:

HIF2α Is an Essential Molecular Brake for Postprandial Hepatic Glucagon Response Independent of Insulin Signaling.
Cell Metab 2016 Mar 4;23(3):505-16. Epub 2016 Feb 4.
Departments of Molecular & Integrative Physiology, Division of Gastroenterology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Internal Medicine, Division of Gastroenterology, University of Michigan Medical School, Ann Arbor, MI 48109, USA. Electronic address:

Mass Spectrometry-Based Metabolomics Identifies Longitudinal Urinary Metabolite Profiles Predictive of Radiation-Induced Cancer.
Cancer Res 2016 Mar 15;76(6):1569-77. Epub 2016 Feb 15.
Department of Veterinary and Biomedical Sciences and the Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, Pennsylvania.

Antioxidant Drug Tempol Promotes Functional Metabolic Changes in the Gut Microbiota.
J Proteome Res 2016 Feb 12;15(2):563-71. Epub 2016 Jan 12.
Center for Molecular Toxicology and Carcinogenesis, Department of Veterinary and Biomedical Sciences, Pennsylvania State University , University Park, State College, Pennsylvania 16802, United States.

Irinotecan (CPT-11)-induced elevation of bile acids potentiates suppression of IL-10 expression.
Toxicol Appl Pharmacol 2016 Jan 17;291:21-7. Epub 2015 Dec 17.
Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. Electronic address:

Interferon-microRNA signalling drives liver precancerous lesion formation and hepatocarcinogenesis.
Gut 2016 07 9;65(7):1186-201. Epub 2016 Feb 9.
International Co-operation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Institute, Second Military Medical University, Shanghai, China National Center for Liver Cancer, Shanghai, China State Key Laboratory for Oncogenes and Related Genes, Cancer Institute of RenJi Hospital, Shanghai JiaoTong University, Shanghai, China.

Urinary Metabolite Risk Biomarkers of Lung Cancer: A Prospective Cohort Study.
Cancer Epidemiol Biomarkers Prev 2016 06 24;25(6):978-86. Epub 2016 Mar 24.
Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.

Ligand activation of peroxisome proliferator-activated receptor-β/δ suppresses liver tumorigenesis in hepatitis B transgenic mice.
Toxicology 2016 07 15;363-364:1-9. Epub 2016 Jul 15.
Department of Veterinary and Biomedical Sciences and The Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA, USA. Electronic address:

Peroxisome proliferator-activated receptor α-dependent renoprotection of murine kidney by irbesartan.
Clin Sci (Lond) 2016 11 5;130(21):1969-1981. Epub 2016 Aug 5.
Department of Metabolic Regulation, Institute of Pathogenesis and Disease Prevention, Shinshu University Graduate School of Medicine, 3-1-1, Asahi, Matsumoto, Nagano, 390-8621, Japan.

Choline Kinase α Mediates Interactions Between the Epidermal Growth Factor Receptor and Mechanistic Target of Rapamycin Complex 2 in Hepatocellular Carcinoma Cells to Promote Drug Resistance and Xenograft Tumor Progression.
Gastroenterology 2017 04 5;152(5):1187-1202. Epub 2017 Jan 5.
International Co-operation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Institute, Second Military Medical University, Shanghai, China; National Center for Liver Cancer, Shanghai, China; Mengchao Hepatobiliary Hospital, Fujian Medical University, Fuzhou, China; Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. Electronic address:

2-Methoxyestradiol Reduces Angiotensin II-Induced Hypertension and Renal Dysfunction in Ovariectomized Female and Intact Male Mice.
Hypertension 2017 06 17;69(6):1104-1112. Epub 2017 Apr 17.
From the Department of Pharmacology, College of Medicine, University of Tennessee Health Science Center, Memphis (A.K.P., K.N.D., S.T., N.S.K., K.U.M.); Department of Physiology, Hypertension & Renal Center, School of Medicine, Tulane University, New Orleans, LA (A.K., D.S.A.M., L.G.N.); and Laboratory of Metabolism, National Cancer Institute, Bethesda, MD (F.J.G.).

An HNF4α-microRNA-194/192 signaling axis maintains hepatic cell function.
J Biol Chem 2017 06 2;292(25):10574-10585. Epub 2017 May 2.
From the Laboratory of Molecular Life Science, Division of Molecular Science, Faculty of Science and Technology, Gunma University, Kiryu, Gunma 376-8515, Japan,

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