Frank J Gonzalez

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100Publications

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Structure-Activity Relationships of the Main Bioactive Constituents of on Aryl Hydrocarbon Receptor Activation and Associated Bile Acid Homeostasis.

Drug Metab Dispos 2018 Jul 24;46(7):1030-1040. Epub 2018 Apr 24.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (Yo.Z., Ti.Y., D.S. C.X., To.Y., K.W.K., F.J.G.); State Key Laboratory of Natural and Biomimetic Drugs and Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing, China (Yo.Z., Yi.Z., L.Z., X.Y.); Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, Oregon (W.H.B.); and College of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang, Liaoning, China (D.S.)

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July 2018

Metabolic profiling of corylin in vivo and in vitro.

J Pharm Biomed Anal 2018 Jun 26;155:157-168. Epub 2018 Mar 26.

College of Pharmacy, Jinan University, Guangzhou 510632, PR China; Guangdong Provincial Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, PR China; Integrated Chinese and Western Medicine Postdoctoral research station, Jinan University, Guangzhou 510632, PR China. Electronic address:

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June 2018

Inverse association of vitamin D levels with lung cancer mediated by genetic variation.

Cancer Med 2018 Jun 3;7(6):2764-2775. Epub 2018 May 3.

Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, 20892.

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June 2018

A metabolomic perspective of pazopanib-induced acute hepatotoxicity in mice.

Xenobiotica 2018 Jun 13:1-53. Epub 2018 Jun 13.

a State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China.

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June 2018

In vitrometabolic mapping of neobavaisoflavone in human cytochromes P450 and UDP-glucuronosyltransferase enzymes by ultra high-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry.

J Pharm Biomed Anal 2018 Jun 18;158:351-360. Epub 2018 Jun 18.

College of Pharmacy, Jinan University, Guangzhou 510632, PR China; Guangdong Provincial Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, PR China; Integrated Chinese and Western Medicine Postdoctoral Research Station, Jinan University, Guangzhou 510632, PR China.

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June 2018

Hepatic peroxisome proliferator-activated receptor alpha mediates the major metabolic effects of Wy-14643.

J Gastroenterol Hepatol 2018 May 19;33(5):1138-1145. Epub 2018 Feb 19.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

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May 2018

Simultaneous determination of etonogestrel and ethinyl estradiol in human plasma by UPLC-MS/MS and its pharmacokinetic study.

Biomed Chromatogr 2018 May 19;32(5):e4165. Epub 2018 Jan 19.

Department of Chemistry, School of Sciences, Gujarat University, Ahmedabad, Gujarat, India.

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May 2018

PPARα Mediates the Hepatoprotective Effects of Nutmeg.

J Proteome Res 2018 May 25;17(5):1887-1897. Epub 2018 Apr 25.

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany , Chinese Academy of Sciences , Kunming 650201 , China.

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May 2018

Inhibition of tumorigenesis by peroxisome proliferator-activated receptor (PPAR)-dependent cell cycle blocks in human skin carcinoma cells.

Toxicology 2018 May 3;404-405:25-32. Epub 2018 May 3.

Department of Veterinary and Biomedical Sciences, The Center of Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA 16802, USA. Electronic address:

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May 2018

Adipocyte-derived Lysophosphatidylcholine Activates Adipocyte and Adipose Tissue Macrophage Nod-Like Receptor Protein 3 Inflammasomes Mediating Homocysteine-Induced Insulin Resistance.

EBioMedicine 2018 May 27;31:202-216. Epub 2018 Apr 27.

Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing 100191, People's Republic of China. Electronic address:

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May 2018

Lipidomics reveal Aryl hydrocarbon receptor (Ahr)-regulated lipid metabolic pathway in alpha-naphthyl isothiocyanate(ANIT)-induced intrahepatic cholestasis.

Xenobiotica 2018 May 8:1-33. Epub 2018 May 8.

c Laboratory of Metabolism , Center for Cancer Research, National Institutes of Health , Bethesda , MD , 20892 , USA.

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May 2018

Metabolic alterations in triptolide-induced acute hepatotoxicity.

Biomed Chromatogr 2018 May 25:e4299. Epub 2018 May 25.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

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May 2018

Metabolic Profiling of the Novel Hypoxia-Inducible Factor 2 Inhibitor PT2385 In Vivo and In Vitro.

Drug Metab Dispos 2018 Apr 23;46(4):336-345. Epub 2018 Jan 23.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (C.X., X.G., D.S., Y.Z., K.W.K., F.J.G.); and Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan, Shanxi, People's Republic of China (X.G., X.Q.)

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April 2018

Targeted Metabolomics Reveals a Protective Role for Basal PPARα in Cholestasis Induced by α-Naphthylisothiocyanate.

J Proteome Res 2018 Apr 7;17(4):1500-1508. Epub 2018 Mar 7.

Ningbo College of Health Sciences , Ningbo 315100 , China.

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April 2018

Metabolic map of osthole and its effect on lipids.

Xenobiotica 2018 Mar 3;48(3):285-299. Epub 2017 Apr 3.

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming , China.

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March 2018

Distinct role of nuclear receptor corepressor 1 regulated de novo fatty acids synthesis in liver regeneration and hepatocarcinogenesis in mice.

Hepatology 2018 Mar 26;67(3):1071-1087. Epub 2018 Jan 26.

The International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China.

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March 2018

Chemical inhibition and stable knock-down of efflux transporters leads to reduced glucuronidation of wushanicaritin in UGT1A1-overexpressing HeLa cells: the role of breast cancer resistance protein (BCRP) and multidrug resistance-associated proteins (MRPs) in the excretion of glucuronides.

Food Funct 2018 Mar 10;9(3):1410-1423. Epub 2018 Jan 10.

College of Pharmacy, Jinan University, Guangzhou 510632, P. R. China. and Guangdong Provincial Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, P. R. China. and Integrated Chinese and Western Medicine Postdoctoral Research Station, Jinan University, Guangzhou 510632, P. R. China and Guangzhou Research and Creativity Biotechnology Co. Ltd, Guangzhou, 510663, P. R. China.

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March 2018

Corrigendum to "Metabolic adaptation to intermittent fasting is independent of peroxisome proliferator-activated receptor alpha" [Mol Metab 7 (2018) 80-89].

Mol Metab 2018 Mar 2;9:217-219. Epub 2018 Feb 2.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:

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March 2018

Fat-specific protein 27 is a novel target gene of liver X receptor α.

Mol Cell Endocrinol 2018 Feb 15. Epub 2018 Feb 15.

Faculty of Pharmaceutical Science, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan.

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February 2018

Intestine farnesoid X receptor agonist and the gut microbiota activate G-protein bile acid receptor-1 signaling to improve metabolism.

Hepatology 2018 Feb 27. Epub 2018 Feb 27.

Department of Integrative Medical Sciences, College of Medicine, Northeast Ohio Medical University, Rootstown, OH.

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February 2018

Hepatocyte nuclear factor 4α regulates the expression of intestinal epithelial Na/H exchanger isoform 3.

Am J Physiol Gastrointest Liver Physiol 2018 01 7;314(1):G14-G21. Epub 2017 Sep 7.

Jesse Brown Veterans Affairs Medical Center , Chicago, Illinois.

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January 2018

Pregnane X receptor promotes ethanol-induced hepatosteatosis in mice.

J Biol Chem 2018 Jan 9;293(1):1-17. Epub 2017 Nov 9.

From the Julius L. Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, North Carolina 27707,

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January 2018

Metabolic adaptation to intermittent fasting is independent of peroxisome proliferator-activated receptor alpha.

Mol Metab 2018 Jan 6;7:80-89. Epub 2017 Nov 6.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:

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January 2018

Growth arrest and DNA damage-inducible 45α protects against nonalcoholic steatohepatitis induced by methionine- and choline-deficient diet.

Biochim Biophys Acta 2017 Dec 24;1863(12):3170-3182. Epub 2017 Aug 24.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States. Electronic address:

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December 2017

Hepatic Aryl hydrocarbon Receptor Nuclear Translocator (ARNT) regulates metabolism in mice.

PLoS One 2017 30;12(11):e0186543. Epub 2017 Nov 30.

The Westmead Institute for Medical Research, The University of Sydney, Sydney, NSW. Australia.

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December 2017

Pharmacophore-based virtual screening of catechol-o-methyltransferase (COMT) inhibitors to combat Alzheimer's disease.

J Biomol Struct Dyn 2017 Dec 27:1-20. Epub 2017 Dec 27.

a Department of Botany, Bioinformatics and Climate Change Impacts Management , University School of Sciences, Gujarat University , Ahmedabad 380 009 , Gujarat , India.

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December 2017

Targeting nuclear receptors for the treatment of fatty liver disease.

Pharmacol Ther 2017 Nov 23;179:142-157. Epub 2017 May 23.

Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

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November 2017

Activation of intestinal hypoxia-inducible factor 2α during obesity contributes to hepatic steatosis.

Nat Med 2017 Nov 9;23(11):1298-1308. Epub 2017 Oct 9.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

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November 2017

Potential role of CYP1B1 in the development and treatment of metabolic diseases.

Pharmacol Ther 2017 Oct 16;178:18-30. Epub 2017 Mar 16.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:

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October 2017

TCDD induces UbcH7 expression and synphilin-1 protein degradation in the mouse ventral midbrain.

J Biochem Mol Toxicol 2017 Oct 16;31(10). Epub 2017 Jun 16.

Departamento de Biología Celular, CINVESTAV-IPN, México D.F, México.

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October 2017

Inhibitory effects of fifteen phthalate esters in human cDNA-expressed UDP-glucuronosyltransferase supersomes.

Chemosphere 2017 Oct 19;185:983-990. Epub 2017 Jul 19.

Department of Toxicology, School of Public Health, Tianjin Medical University, 22 Qixiangtai Road, Heping District, Tianjin, China. Electronic address:

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October 2017

A Western diet-induced mouse model reveals a possible mechanism by which metformin decreases obesity.

Eur J Clin Pharmacol 2017 Oct 22;73(10):1337-1339. Epub 2017 Aug 22.

Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, and the Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, People's Republic of China.

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October 2017

Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota.

Cell Metab 2017 Oct 14;26(4):672-685.e4. Epub 2017 Sep 14.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:

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October 2017

Editor's Highlight: PPARβ/δ and PPARγ Inhibit Melanoma Tumorigenicity by Modulating Inflammation and Apoptosis.

Toxicol Sci 2017 Oct;159(2):436-448

Department of Veterinary and Biomedical Sciences, The Center of Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, Pennsylvania 16802.

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October 2017

Nuclear Receptor PPARα Agonist Wy-14,643 Ameliorates Hepatic Cell Death in Hepatic IKKβ-Deficient Mice.

Biomol Ther (Seoul) 2017 Sep;25(5):504-510

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

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September 2017

Unique and Novel Urinary Metabolomic Features in Malignant versus Benign Adrenal Neoplasms.

Clin Cancer Res 2017 Sep 27;23(17):5302-5310. Epub 2017 Apr 27.

Endocrine Oncology Branch, NCI, NIH, Bethesda, Maryland.

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September 2017

Metabolic profiling by gas chromatography-mass spectrometry of energy metabolism in high-fat diet-fed obese mice.

PLoS One 2017 16;12(5):e0177953. Epub 2017 May 16.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States of America.

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September 2017

Lack of epithelial PPARγ causes cystic adenomatoid malformations in mouse fetal lung.

Biochem Biophys Res Commun 2017 09 21;491(2):271-276. Epub 2017 Jul 21.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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September 2017

Orthogonal Comparison of GC-MS and H NMR Spectroscopy for Short Chain Fatty Acid Quantitation.

Anal Chem 2017 Aug 12;89(15):7900-7906. Epub 2017 Jul 12.

Center for Molecular Toxicology and Carcinogenesis, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University , University Park, Pennsylvania 16802, United States.

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August 2017

Inflammation is independent of steatosis in a murine model of steatohepatitis.

Hepatology 2017 07 18;66(1):108-123. Epub 2017 May 18.

Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD.

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July 2017

Vascular smooth muscle cell peroxisome proliferator-activated receptor γ protects against endothelin-1-induced oxidative stress and inflammation.

J Hypertens 2017 Jul;35(7):1390-1401

aHypertension and Vascular Research Unit, Lady Davis Institute for Medical Research bDepartment of Medicine, Sir Mortimer B. Davis-Jewish General Hospital, McGill University, Montreal, Quebec, Canada cDepartment of Clinical Medicine, State University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil dDepartment of Pharmacology, Max-Planck-Institute for Heart and Lung Research, Bad Nauheim, Germany eLaboratory of Metabolism, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA *Noureddine Idris-Khodja and Sofiane Ouerd contributed equally to the article.

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July 2017

Glycyrrhizin and glycyrrhetinic acid inhibits alpha-naphthyl isothiocyanate-induced liver injury and bile acid cycle disruption.

Toxicology 2017 07 24;386:133-142. Epub 2017 May 24.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, United States. Electronic address:

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July 2017

Inhibition of human CYP3A4 and CYP3A5 enzymes by gomisin C and gomisin G, two lignan analogs derived from Schisandra chinensis.

Fitoterapia 2017 Jun 24;119:26-31. Epub 2017 Mar 24.

School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address:

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June 2017

2-Methoxyestradiol Reduces Angiotensin II-Induced Hypertension and Renal Dysfunction in Ovariectomized Female and Intact Male Mice.

Hypertension 2017 06 17;69(6):1104-1112. Epub 2017 Apr 17.

From the Department of Pharmacology, College of Medicine, University of Tennessee Health Science Center, Memphis (A.K.P., K.N.D., S.T., N.S.K., K.U.M.); Department of Physiology, Hypertension & Renal Center, School of Medicine, Tulane University, New Orleans, LA (A.K., D.S.A.M., L.G.N.); and Laboratory of Metabolism, National Cancer Institute, Bethesda, MD (F.J.G.).

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June 2017

An HNF4α-microRNA-194/192 signaling axis maintains hepatic cell function.

J Biol Chem 2017 06 2;292(25):10574-10585. Epub 2017 May 2.

From the Laboratory of Molecular Life Science, Division of Molecular Science, Faculty of Science and Technology, Gunma University, Kiryu, Gunma 376-8515, Japan,

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June 2017

Role of the lipid-regulated NF-κB/IL-6/STAT3 axis in alpha-naphthyl isothiocyanate-induced liver injury.

Arch Toxicol 2017 May 16;91(5):2235-2244. Epub 2016 Nov 16.

Laboratory of Metabolism, Center for Cancer Research, National Institutes of Health, Building 37, Room 3106, Bethesda, MD, 20892, USA.

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May 2017

Peroxisome proliferator-activated receptor-β/δ inhibits human neuroblastoma cell tumorigenesis by inducing p53- and SOX2-mediated cell differentiation.

Mol Carcinog 2017 05 13;56(5):1472-1483. Epub 2017 Jan 13.

Department of Veterinary and Biomedical Sciences and The Center of Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, Pennsylvania.

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May 2017

Intestinal Farnesoid X Receptor Signaling Modulates Metabolic Disease.

Dig Dis 2017 1;35(3):178-184. Epub 2017 Mar 1.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Md., USA.

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May 2017

Metabolomic Analysis of Mice Exposed to Gamma Radiation Reveals a Systemic Understanding of Total-Body Exposure.

Radiat Res 2017 05 9;187(5):612-629. Epub 2017 Mar 9.

a   Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.

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May 2017

Peroxisome proliferator-activated receptor-β/δ modulates mast cell phenotype.

Immunology 2017 04 24;150(4):456-467. Epub 2017 Jan 24.

Department of Veterinary and Biomedical Sciences, The Center of Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA, USA.

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April 2017

Choline Kinase α Mediates Interactions Between the Epidermal Growth Factor Receptor and Mechanistic Target of Rapamycin Complex 2 in Hepatocellular Carcinoma Cells to Promote Drug Resistance and Xenograft Tumor Progression.

Gastroenterology 2017 04 5;152(5):1187-1202. Epub 2017 Jan 5.

International Co-operation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Institute, Second Military Medical University, Shanghai, China; National Center for Liver Cancer, Shanghai, China; Mengchao Hepatobiliary Hospital, Fujian Medical University, Fuzhou, China; Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. Electronic address:

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April 2017

Schisandrol B protects against cholestatic liver injury through pregnane X receptors.

Br J Pharmacol 2017 04 16;174(8):672-688. Epub 2017 Mar 16.

School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China.

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April 2017

Farnesoid X Receptor Regulation of the NLRP3 Inflammasome Underlies Cholestasis-Associated Sepsis.

Cell Metab 2017 Apr;25(4):856-867.e5

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA. Electronic address:

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April 2017

Hepatocyte-specific PPARA expression exclusively promotes agonist-induced cell proliferation without influence from nonparenchymal cells.

Am J Physiol Gastrointest Liver Physiol 2017 Mar 12;312(3):G283-G299. Epub 2017 Jan 12.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland

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March 2017

An Intestinal Farnesoid X Receptor-Ceramide Signaling Axis Modulates Hepatic Gluconeogenesis in Mice.

Diabetes 2017 03 8;66(3):613-626. Epub 2016 Nov 8.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD

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March 2017

PPARα-dependent increase of mouse urine output by gemfibrozil and fenofibrate.

Can J Physiol Pharmacol 2017 Feb 6;95(2):199-205. Epub 2016 Sep 6.

a Medical School of Ningbo University, Ningbo 315211, China.

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February 2017

PPARα protects against trans-fatty-acid-containing diet-induced steatohepatitis.

J Nutr Biochem 2017 Jan 11;39:77-85. Epub 2016 Oct 11.

Department of Metabolic Regulation, Shinshu University Graduate School of Medicine, Matsumoto, Japan.

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January 2017

Effects of disease salience and xenophobia on support for humanitarian aid.

Politics Life Sci 2017 ;36(2):17-36

3University of Nebraska,Lincoln.

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January 2017

Age-dependent PPARα activation induces hepatic sulfatide accumulation in transgenic mice carrying the hepatitis C virus core gene.

Glycoconj J 2016 12 18;33(6):927-936. Epub 2016 Jun 18.

Department of Metabolic Regulation, Shinshu University Graduate School of Medicine, Matsumoto, 390-8621, Japan.

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December 2016

Cyp2c70 is responsible for the species difference in bile acid metabolism between mice and humans.

J Lipid Res 2016 12 16;57(12):2130-2137. Epub 2016 Sep 16.

Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892

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December 2016

Identification and characterization of PPARα ligands in the hippocampus.

Nat Chem Biol 2016 Dec 17;12(12):1075-1083. Epub 2016 Oct 17.

Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA.

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December 2016

Peroxisome proliferator-activated receptor α-dependent renoprotection of murine kidney by irbesartan.

Clin Sci (Lond) 2016 11 5;130(21):1969-1981. Epub 2016 Aug 5.

Department of Metabolic Regulation, Institute of Pathogenesis and Disease Prevention, Shinshu University Graduate School of Medicine, 3-1-1, Asahi, Matsumoto, Nagano, 390-8621, Japan.

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November 2016

The antiandrogen flutamide is a novel aryl hydrocarbon receptor ligand that disrupts bile acid homeostasis in mice through induction of Abcc4.

Biochem Pharmacol 2016 Nov 26;119:93-104. Epub 2016 Aug 26.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:

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November 2016

An Intestinal Microbiota-Farnesoid X Receptor Axis Modulates Metabolic Disease.

Gastroenterology 2016 11 14;151(5):845-859. Epub 2016 Sep 14.

Department of Veterinary and Biomedical Sciences and the Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, Pennsylvania.

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November 2016

Regulation of Cytochrome P450 2B10 (CYP2B10) Expression in Liver by Peroxisome Proliferator-activated Receptor-β/δ Modulation of SP1 Promoter Occupancy.

J Biol Chem 2016 Nov 20;291(48):25255-25263. Epub 2016 Oct 20.

From the Department of Veterinary and Biomedical Sciences and the Center of Molecular Toxicology and Carcinogenesis, Pennsylvania State University, University Park, Pennsylvania 16802,

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November 2016

Farnesoid X receptor activation increases reverse cholesterol transport by modulating bile acid composition and cholesterol absorption in mice.

Hepatology 2016 10 30;64(4):1072-85. Epub 2016 Jul 30.

Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH.

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October 2016

Phosphorylation of Farnesoid X Receptor at Serine 154 Links Ligand Activation With Degradation.

Mol Endocrinol 2016 Oct 29;30(10):1070-1080. Epub 2016 Aug 29.

Pharmacogenetics Section (T.H., S.A., T.S., M.N.), Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709; and Laboratory of Metabolism (S.T., F.J.G.), Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892.

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October 2016

Farnesoid X Receptor Signaling Shapes the Gut Microbiota and Controls Hepatic Lipid Metabolism.

mSystems 2016 Sep-Oct;1(5). Epub 2016 Oct 11.

Center for Molecular Toxicology and Carcinogenesis, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, Pennsylvania, USA.

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October 2016

Chlorogenic acid inhibits cholestatic liver injury induced by α-naphthylisothiocyanate: involvement of STAT3 and NFκB signalling regulation.

J Pharm Pharmacol 2016 Sep 1;68(9):1203-13. Epub 2016 Jul 1.

Key Laboratory of Phytochemical R&D of Hunan Province, Hunan Normal University, Changsha, China.

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September 2016

Metabolism and Bioactivation of Fluorochloridone, a Novel Selective Herbicide, in Vivo and in Vitro.

Environ Sci Technol 2016 09 5;50(17):9652-60. Epub 2016 Aug 5.

School of Public Health, Fudan University , Shanghai 200032, PR China.

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September 2016

ISN Forefronts Symposium 2015: Nuclear Receptors and Diabetic Nephropathy.

Kidney Int Rep 2016 Sep 5;1(3):177-188. Epub 2016 Aug 5.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.

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September 2016

PPARα activation drives demethylation of the CpG islands of the Gadd45b promoter in the mouse liver.

Biochem Biophys Res Commun 2016 08 24;476(4):293-298. Epub 2016 May 24.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, USA.

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August 2016

Cytochrome P450 1B1 Contributes to the Development of Angiotensin II-Induced Aortic Aneurysm in Male Apoe(-/-) Mice.

Am J Pathol 2016 Aug 11;186(8):2204-2219. Epub 2016 Jun 11.

Department of Pharmacology, College of Medicine, The University of Tennessee Health Science Center, Memphis, Tennessee. Electronic address:

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August 2016

Ligand activation of peroxisome proliferator-activated receptor-β/δ suppresses liver tumorigenesis in hepatitis B transgenic mice.

Toxicology 2016 07 15;363-364:1-9. Epub 2016 Jul 15.

Department of Veterinary and Biomedical Sciences and The Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA, USA. Electronic address:

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July 2016

Political conservatism predicts asymmetries in emotional scene memory.

Behav Brain Res 2016 06 15;306:84-90. Epub 2016 Mar 15.

Department of Psychology, University of Nebraska, Lincoln, NE, United States.

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June 2016

Urinary Metabolite Risk Biomarkers of Lung Cancer: A Prospective Cohort Study.

Cancer Epidemiol Biomarkers Prev 2016 06 24;25(6):978-86. Epub 2016 Mar 24.

Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.

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June 2016

Metabolomics reveals mycoplasma contamination interferes with the metabolism of PANC-1 cells.

Anal Bioanal Chem 2016 Jun 13;408(16):4267-73. Epub 2016 Apr 13.

School of Pharmaceutical Sciences, Sun Yat-sen University, 132# Waihuandong Rd, University City of Guangzhou, Guangzhou, 510006, China.

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June 2016

Aryl hydrocarbon receptor influences nitric oxide and arginine production and alters M1/M2 macrophage polarization.

Life Sci 2016 Jun 3;155:76-84. Epub 2016 May 3.

Departamento de Biología Celular, CINVESTAV-IPN, Zacatenco, Av. IPN 2508, C.P. 07360 México D.F., Mexico. Electronic address:

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June 2016

6β-Hydroxytestosterone, a Cytochrome P450 1B1-Testosterone-Metabolite, Mediates Angiotensin II-Induced Renal Dysfunction in Male Mice.

Hypertension 2016 May 29;67(5):916-26. Epub 2016 Feb 29.

From the Department of Pharmacology (A.K.P., S.T., M.K., K.U.M.) and Department of Medicine and Microbiology, Immunology and Biochemistry (D.D.B.), College of Medicine, University of Tennessee Health Science Center, Memphis; Veterans Affairs Medical Center, Memphis, TN (D.D.B.); Tulane Hypertension and Renal Center of Excellence, Department of Physiology, School of Medicine, Tulane University, New Orleans, LA (A.K., D.S.A.M., L.G.N.); and Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, Bethesda, MD (F.J.G.).

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May 2016

Glycyrrhizin Protects against Acetaminophen-Induced Acute Liver Injury via Alleviating Tumor Necrosis Factor α-Mediated Apoptosis.

Drug Metab Dispos 2016 May 10;44(5):720-31. Epub 2016 Mar 10.

State Key Laboratory of Natural Medicines, Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, Jiangsu, People's Republic of China (Ti.Y., H.W., M.Z., Yi.C., X.C., J.Z., Yu.C., F.L., Y.W., G.W., H.H.); Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (Ti.Y., To.Y., K.W.K., C.X., C.N.B., F.J.G.)

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May 2016

A lipidomics investigation into the intervention of celastrol in experimental colitis.

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Department of Pharmaceutical Analysis, School of Pharmacy, Second Military Medical University, Shanghai 200433, China. and Department of Pharmaceutical Analysis, School of Pharmacy, Fudan University, Shanghai 201203, China.

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Mass Spectrometry-Based Metabolomics Identifies Longitudinal Urinary Metabolite Profiles Predictive of Radiation-Induced Cancer.

Cancer Res 2016 Mar 15;76(6):1569-77. Epub 2016 Feb 15.

Department of Veterinary and Biomedical Sciences and the Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, Pennsylvania.

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March 2016