Publications by authors named "Frank J Gonzalez"

100Publications

Human CYP2D6 in the Brain Is Protective Against Harmine-Induced Neurotoxicity: Evidence from Humanized CYP2D6 Transgenic Mice.

Mol Neurobiol 2020 Nov 6;57(11):4608-4621. Epub 2020 Aug 6.

Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada.

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http://dx.doi.org/10.1007/s12035-020-02050-wDOI Listing
November 2020

Investigation on the metabolic characteristics of isobavachin in Psoralea corylifolia L. (Bu-gu-zhi) and its potential inhibition against human cytochrome P450s and UDP-glucuronosyltransferases.

J Pharm Pharmacol 2020 Aug 4. Epub 2020 Aug 4.

Guangdong Provincial Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, China.

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http://dx.doi.org/10.1111/jphp.13337DOI Listing
August 2020

HNF1α controls glucagon secretion in pancreatic α-cells through modulation of SGLT1.

Biochim Biophys Acta Mol Basis Dis 2020 Nov 22;1866(11):165898. Epub 2020 Jul 22.

Department of Medical Biochemistry, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8556, Japan; Center for Metabolic Regulation of Healthy Aging (CMHA), Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8556, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2020.165898DOI Listing
November 2020

Dexamethasone-Induced Liver Enlargement Is Related to PXR/YAP Activation and Lipid Accumulation but Not Hepatocyte Proliferation.

Drug Metab Dispos 2020 Sep 19;48(9):830-839. Epub 2020 Jun 19.

Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China (T.J., X.P.Y., Yi.Z., Ya.Z., Y.G., S.F., P.C., X.L., Y.J., X.Y., M.H., H.B.) and Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland (F.J.G.)

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http://dx.doi.org/10.1124/dmd.120.000061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7497622PMC
September 2020

Synergistic regulation of hepatic Fsp27b expression by HNF4α and CREBH.

Biochem Biophys Res Commun 2020 Sep 15;530(2):432-439. Epub 2020 Jun 15.

Division of Molecular Science, Graduate School of Science and Technology, Gunma University, Kiryu, Gunma, 376-8515, Japan; Gunma University Center for Food Science and Wellness, Maebashi, Gunma, 371-8510, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2020.05.070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7484291PMC
September 2020

Celastrol ameliorates acute liver injury through modulation of PPARα.

Biochem Pharmacol 2020 Aug 26;178:114058. Epub 2020 May 26.

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China; Department of Gastroenterology and Hepatology, Sichuan University-Oxford University Huaxi Gastrointestinal Cancer Centre, West China Hospital, Sichuan University, Chengdu 610065, China. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2020.114058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7377972PMC
August 2020

Upregulation of BDNF and hippocampal functions by a hippocampal ligand of PPARα.

JCI Insight 2020 May 21;5(10). Epub 2020 May 21.

Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA.

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http://dx.doi.org/10.1172/jci.insight.136654DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259538PMC
May 2020

PPARs as Metabolic Regulators in the Liver: Lessons from Liver-Specific PPAR-Null Mice.

Int J Mol Sci 2020 Mar 17;21(6). Epub 2020 Mar 17.

Department of Metabolic Regulation, Shinshu University School of Medicine, Matsumoto, Nagano 390-8621, Japan.

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http://dx.doi.org/10.3390/ijms21062061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139552PMC
March 2020

Human CYP2D6 Is Functional in Brain In Vivo: Evidence from Humanized CYP2D6 Transgenic Mice.

Mol Neurobiol 2020 Jun 18;57(6):2509-2520. Epub 2020 Mar 18.

Department of Pharmacology and Toxicology, University of Toronto, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada.

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http://dx.doi.org/10.1007/s12035-020-01896-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383223PMC
June 2020

Sex steroid hormones differentially regulate CYP2D in female wild-type and CYP2D6-humanized mice.

J Endocrinol 2020 May;245(2):301-314

National Institutes of Health, National Cancer Institute, Laboratory of Metabolism, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1530/JOE-19-0561DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202972PMC
May 2020

Metabolomic profiling of metoprolol hypertension treatment reveals altered gut microbiota-derived urinary metabolites.

Hum Genomics 2020 03 11;14(1):10. Epub 2020 Mar 11.

Department of Emergency Medicine & Colorado Center for Personalized Medicine, University of Colorado School of Medicine, Aurora, CO, USA.

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http://dx.doi.org/10.1186/s40246-020-00260-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066769PMC
March 2020

Central CYP1B1 (Cytochrome P450 1B1)-Estradiol Metabolite 2-Methoxyestradiol Protects From Hypertension and Neuroinflammation in Female Mice.

Hypertension 2020 Apr 9;75(4):1054-1062. Epub 2020 Mar 9.

From the Department of Pharmacology, Addiction Science, and Toxicology, College of Medicine, University of Tennessee Health Science Center, Memphis (P.S., C.Y.S., S.R.D., K.U.M.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.119.14548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7098446PMC
April 2020

Herbal drug discovery for the treatment of nonalcoholic fatty liver disease.

Acta Pharm Sin B 2020 Jan 10;10(1):3-18. Epub 2019 Dec 10.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.apsb.2019.11.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977016PMC
January 2020

6β-Hydroxytestosterone, a metabolite of testosterone generated by CYP1B1, contributes to vascular changes in angiotensin II-induced hypertension in male mice.

Biol Sex Differ 2020 01 16;11(1). Epub 2020 Jan 16.

Department of Pharmacology, College of Medicine, University of Tennessee Health Science Center, 71 S. Manassas TSRB, Memphis, TN, 38103, USA.

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http://dx.doi.org/10.1186/s13293-019-0280-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966856PMC
January 2020

SUMOylation inhibitors synergize with FXR agonists in combating liver fibrosis.

Nat Commun 2020 01 13;11(1):240. Epub 2020 Jan 13.

State Key Laboratory of Natural Medicines, Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, 210009, Nanjing, China.

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http://dx.doi.org/10.1038/s41467-019-14138-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957516PMC
January 2020

Rutaecarpine inhibits KEAP1-NRF2 interaction to activate NRF2 and ameliorate dextran sulfate sodium-induced colitis.

Free Radic Biol Med 2020 02 23;148:33-41. Epub 2019 Dec 23.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2019.12.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376370PMC
February 2020

Propranolol is a mechanism-based inhibitor of CYP2D and CYP2D6 in humanized CYP2D6-transgenic mice: Effects on activity and drug responses.

Br J Pharmacol 2020 Feb 6;177(3):701-712. Epub 2020 Jan 6.

Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Department of Pharmacology & Toxicology, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1111/bph.14884DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012948PMC
February 2020

A multiparametric organ toxicity predictor for drug discovery.

Toxicol Mech Methods 2020 Mar 29;30(3):159-166. Epub 2019 Oct 29.

Department of Botany, Bioinformatics and Climate Change Impacts Management, University School of Sciences, Gujarat University, Ahmedabad, India.

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http://dx.doi.org/10.1080/15376516.2019.1681044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383222PMC
March 2020

Unraveling the role of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) expression in colon carcinogenesis.

NPJ Precis Oncol 2019 7;3:26. Epub 2019 Oct 7.

3Laboratory of Metabolism, National Cancer Institute, Bethesda, MD USA.

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http://dx.doi.org/10.1038/s41698-019-0098-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779880PMC
October 2019

The essential role of the transporter ABCG2 in the pathophysiology of erythropoietic protoporphyria.

Sci Adv 2019 09 18;5(9):eaaw6127. Epub 2019 Sep 18.

Center for Pharmacogenetics, Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA.

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http://dx.doi.org/10.1126/sciadv.aaw6127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750912PMC
September 2019

Publisher Correction: Gut microbiota-bile acid-interleukin-22 axis orchestrates polycystic ovary syndrome.

Nat Med 2019 Sep;25(9):1459

Department of Obstetrics and Gynecology, Center for Obesity and Metabolic Disease Research, School of Basic Medical Sciences, Third Hospital, Peking University, Beijing, China.

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http://www.nature.com/articles/s41591-019-0562-8
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http://dx.doi.org/10.1038/s41591-019-0562-8DOI Listing
September 2019

Metabolic Activation of Elemicin Leads to the Inhibition of Stearoyl-CoA Desaturase 1.

Chem Res Toxicol 2019 10 10;32(10):1965-1976. Epub 2019 Sep 10.

States Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany , Chinese Academy of Sciences , Kunming 650201 , China.

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http://dx.doi.org/10.1021/acs.chemrestox.9b00112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397737PMC
October 2019

Dietary Intake Regulates the Circulating Inflammatory Monocyte Pool.

Cell 2019 08;178(5):1102-1114.e17

Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA; The Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.07.050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7357241PMC
August 2019

Withaferin A Improves Nonalcoholic Steatohepatitis in Mice.

J Pharmacol Exp Ther 2019 11 16;371(2):360-374. Epub 2019 Aug 16.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (D.P.P., T.Y., D.K., H.B.D., K.W.K., S.K., F.J.G.) and Laboratory of Cellular Biophysics and Inflammation, Pontifical Catholic University of Rio Grande do Sul, Rio Grande do Sul, Brazil (H.B.D.)

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http://dx.doi.org/10.1124/jpet.119.256792DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800446PMC
November 2019

Gut microbiota-bile acid-interleukin-22 axis orchestrates polycystic ovary syndrome.

Nat Med 2019 08 22;25(8):1225-1233. Epub 2019 Jul 22.

Department of Obstetrics and Gynecology, Center for Obesity and Metabolic Disease Research, School of Basic Medical Sciences, Third Hospital, Peking University, Beijing, China.

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http://dx.doi.org/10.1038/s41591-019-0509-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376369PMC
August 2019

Hypoxia inducible factor 1α in vascular smooth muscle cells promotes angiotensin II-induced vascular remodeling via activation of CCL7-mediated macrophage recruitment.

Cell Death Dis 2019 07 18;10(8):544. Epub 2019 Jul 18.

Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University; Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education, Beijing, China.

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http://dx.doi.org/10.1038/s41419-019-1757-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639417PMC
July 2019

A trans-fatty acid-rich diet promotes liver tumorigenesis in HCV core gene transgenic mice.

Carcinogenesis 2020 04;41(2):159-170

Department of Metabolic Regulation, Shinshu University School of Medicine, Matsumoto, Japan.

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http://dx.doi.org/10.1093/carcin/bgz132DOI Listing
April 2020

Role of Metabolic Activation in Elemicin-Induced Cellular Toxicity.

J Agric Food Chem 2019 Jul 16;67(29):8243-8252. Epub 2019 Jul 16.

State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China.

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http://dx.doi.org/10.1021/acs.jafc.9b02137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7385589PMC
July 2019

Non-targeted metabolomics reveals diagnostic biomarker in the tongue coating of patients with chronic gastritis.

J Pharm Biomed Anal 2019 Sep 20;174:541-551. Epub 2019 Jun 20.

Hebei Province Hospital of Traditional Chinese Medicine, Shijiazhuang, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.jpba.2019.06.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383221PMC
September 2019

The Protective Roles of PPARα Activation in Triptolide-induced Liver Injury.

Toxicol Sci 2019 Jun 26. Epub 2019 Jun 26.

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China.

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http://dx.doi.org/10.1093/toxsci/kfz146DOI Listing
June 2019

Adrenoceptor-related decrease in serum triglycerides is independent of PPARα activation.

FEBS J 2019 11 28;286(21):4328-4341. Epub 2019 Jun 28.

Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1111/febs.14966DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829030PMC
November 2019

Hepatocyte peroxisome proliferator-activated receptor α regulates bile acid synthesis and transport.

Biochim Biophys Acta Mol Cell Biol Lipids 2019 10 10;1864(10):1396-1411. Epub 2019 Jun 10.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 2089, United States of America. Electronic address:

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http://dx.doi.org/10.1016/j.bbalip.2019.05.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7423166PMC
October 2019

Intestinal PPARα Protects Against Colon Carcinogenesis via Regulation of Methyltransferases DNMT1 and PRMT6.

Gastroenterology 2019 09 30;157(3):744-759.e4. Epub 2019 May 30.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00165085194097
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http://dx.doi.org/10.1053/j.gastro.2019.05.057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7388731PMC
September 2019

β Cell Hypoxia-Inducible Factor-1α Is Required for the Prevention of Type 1 Diabetes.

Cell Rep 2019 05;27(8):2370-2384.e6

Center for Diabetes, Obesity, and Endocrinology (CDOE), The Westmead Institute for Medical Research (WIMR), The University of Sydney, Sydney, NSW, Australia; Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia; St Vincent's Clinical School, University of New South Wales, Kensington, NSW, Australia; Department of Diabetes and Endocrinology, Westmead Hospital, Sydney, NSW, Australia. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247193056
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http://dx.doi.org/10.1016/j.celrep.2019.04.086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6661122PMC
May 2019

Regulatory mechanisms mediated by peroxisome proliferator-activated receptor-β/δ in skin cancer.

Mol Carcinog 2019 09 6;58(9):1612-1622. Epub 2019 May 6.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.

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http://dx.doi.org/10.1002/mc.23033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6692234PMC
September 2019

Pregnane X receptor activation potentiates ritonavir hepatotoxicity.

J Clin Invest 2019 04 30;129(7):2898-2903. Epub 2019 Apr 30.

Center for Pharmacogenetics, Department of Pharmaceutical Sciences, School of Pharmacy, and.

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http://www.jci.org/articles/view/128274
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http://dx.doi.org/10.1172/JCI128274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597219PMC
April 2019

Impaired clearance of sunitinib leads to metabolic disorders and hepatotoxicity.

Br J Pharmacol 2019 07 7;176(13):2162-2178. Epub 2019 May 7.

State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China.

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http://dx.doi.org/10.1111/bph.14664DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555861PMC
July 2019

Hepatic metabolic adaptation in a murine model of glutathione deficiency.

Chem Biol Interact 2019 Apr 20;303:1-6. Epub 2019 Feb 20.

Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT, 06520, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cbi.2019.02.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743730PMC
April 2019

Modulation of Lipid Metabolism by Celastrol.

J Proteome Res 2019 03 12;18(3):1133-1144. Epub 2019 Feb 12.

State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China.

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http://pubs.acs.org/doi/10.1021/acs.jproteome.8b00797
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http://dx.doi.org/10.1021/acs.jproteome.8b00797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6626529PMC
March 2019

Keratin 23 Is a Peroxisome Proliferator-Activated Receptor Alpha-Dependent, MYC-Amplified Oncogene That Promotes Hepatocyte Proliferation.

Hepatology 2019 07 20;70(1):154-167. Epub 2019 Mar 20.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD.

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http://dx.doi.org/10.1002/hep.30530DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597269PMC
July 2019

In utero exposure to di(2-ethylhexyl)phthalate suppresses blood glucose and leptin levels in the offspring of wild-type mice.

Toxicology 2019 03 17;415:49-55. Epub 2019 Jan 17.

College of Life and Health Sciences, Chubu University, 1200 Matsumoto-cho, Kasugai, Aichi, 487-8501, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.tox.2019.01.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628919PMC
March 2019

A systemic workflow for profiling metabolome and lipidome in tissue.

J Chromatogr A 2019 Mar 30;1589:105-115. Epub 2018 Dec 30.

School of Public Health/MOE Key Lab for Public Health, Fudan University, Shanghai, 200032, China. Electronic address:

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http://dx.doi.org/10.1016/j.chroma.2018.12.061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628932PMC
March 2019

The Evolution of Carcinogenesis.

Toxicol Sci 2018 10;165(2):272-276

Laboratory of Metabolism, National Cancer Institute, Bethesda, Maryland 20892.

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http://dx.doi.org/10.1093/toxsci/kfy184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154269PMC
October 2018

Celastrol Protects From Cholestatic Liver Injury Through Modulation of SIRT1-FXR Signaling.

Mol Cell Proteomics 2019 03 7;18(3):520-533. Epub 2019 Jan 7.

From the ‡State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;

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http://dx.doi.org/10.1074/mcp.RA118.000817DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398203PMC
March 2019

Adrenoceptor-stimulated inflammatory response in stress-induced serum amyloid A synthesis.

Psychopharmacology (Berl) 2019 Jun 6;236(6):1687-1699. Epub 2019 Jan 6.

Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1007/s00213-018-5149-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6643287PMC
June 2019

Endothelial Cell-Targeted Deletion of PPAR Blocks Rosiglitazone-Induced Plasma Volume Expansion and Vascular Remodeling in Adipose Tissue.

J Pharmacol Exp Ther 2019 03 3;368(3):514-523. Epub 2019 Jan 3.

Cardiometabolic Disorders Department, Merck Research Laboratories, Kenilworth, New Jersey (T.E.A., L.A.M., N.S., E.I.Z., H.L., J.W.W., C.H.C., J.P.B.); Department of Pathology and Molecular Medicine (G.E.S.-G., E.D.L., C.J.B.N.), Cancer Biology and Genetics Division, Cancer Research Institute (R.E.R., C.J.B.N.), and Department of Biomedical and Molecular Sciences (J.Y.S., C.J.B.N.), Queen's University, Kingston, Ontario, Canada; National Cancer Institute, National Institutes of Health, Bethesda, Maryland (F.J.G.); and Takeda Pharmaceuticals International, Inc., Cambridge, Massachusetts (J.P.B.)

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http://dx.doi.org/10.1124/jpet.118.250985DOI Listing
March 2019

Role of Farnesoid X Receptor and Bile Acids in Hepatic Tumor Development.

Hepatol Commun 2018 Dec 1;2(12):1567-1582. Epub 2018 Oct 1.

Laboratory of Metabolism National Cancer Institute, National Institutes of Health Bethesda MD.

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http://dx.doi.org/10.1002/hep4.1263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287584PMC
December 2018

Hepatocyte Peroxisome Proliferator-Activated Receptor α Enhances Liver Regeneration after Partial Hepatectomy in Mice.

Am J Pathol 2019 02 16;189(2):272-282. Epub 2018 Nov 16.

Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education, Capital Medical University, Beijing, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00029440183019
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http://dx.doi.org/10.1016/j.ajpath.2018.10.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593252PMC
February 2019

Gut microbiota and intestinal FXR mediate the clinical benefits of metformin.

Nat Med 2018 12 5;24(12):1919-1929. Epub 2018 Nov 5.

Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, and the Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China.

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http://www.nature.com/articles/s41591-018-0222-4
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http://dx.doi.org/10.1038/s41591-018-0222-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6479226PMC
December 2018

Bioengineered miRNA-1291 prodrug therapy in pancreatic cancer cells and patient-derived xenograft mouse models.

Cancer Lett 2019 02 30;442:82-90. Epub 2018 Oct 30.

Department of Biochemistry & Molecular Medicine, UC Davis School of Medicine, Sacramento, CA, 95817, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03043835183065
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http://dx.doi.org/10.1016/j.canlet.2018.10.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311422PMC
February 2019

Peroxisome proliferator-activated receptor α attenuates high-cholesterol diet-induced toxicity and pro-thrombotic effects in mice.

Arch Toxicol 2019 01 19;93(1):149-161. Epub 2018 Oct 19.

Department of Metabolic Regulation, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, Japan.

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http://dx.doi.org/10.1007/s00204-018-2335-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6661123PMC
January 2019

Noncanonical farnesoid X receptor signaling inhibits apoptosis and impedes liver fibrosis.

EBioMedicine 2018 Nov 15;37:322-333. Epub 2018 Oct 15.

State Key Laboratory of Natural Medicines, Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, China. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2018.10.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286639PMC
November 2018

The role of hypoxia-inducible factors in metabolic diseases.

Nat Rev Endocrinol 2018 12;15(1):21-32

Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China.

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http://dx.doi.org/10.1038/s41574-018-0096-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6624429PMC
December 2018

The roles of breast cancer resistance protein (BCRP/ABCG2) and multidrug resistance-associated proteins (MRPs/ABCCs) in the excretion of cycloicaritin-3-O-glucoronide in UGT1A1-overexpressing HeLa cells.

Chem Biol Interact 2018 Dec 17;296:45-56. Epub 2018 Sep 17.

College of Pharmacy, Jinan University, Guangzhou, 510632, PR China; Guangdong Provincial Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632, PR China.

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http://dx.doi.org/10.1016/j.cbi.2018.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628920PMC
December 2018

Induction of Hepatic Metabolic Functions by a Novel Variant of Hepatocyte Nuclear Factor 4γ.

Mol Cell Biol 2018 12 28;38(24). Epub 2018 Nov 28.

Division of Molecular Science, Graduate School of Science and Technology, Gunma University, Kiryu, Gunma, Japan

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http://dx.doi.org/10.1128/MCB.00213-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275183PMC
December 2018

Extrahepatic PPARα modulates fatty acid oxidation and attenuates fasting-induced hepatosteatosis in mice.

J Lipid Res 2018 11 29;59(11):2140-2152. Epub 2018 Aug 29.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892

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http://www.jlr.org/lookup/doi/10.1194/jlr.M088419
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http://dx.doi.org/10.1194/jlr.M088419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210912PMC
November 2018

The lncRNA HOTAIR transcription is controlled by HNF4α-induced chromatin topology modulation.

Cell Death Differ 2019 05 28;26(5):890-901. Epub 2018 Aug 28.

Istituto Pasteur-Fondazione Cenci Bolognetti, Department of Cellular Biotechnologies and Haematology, Sapienza University of Rome, Rome, Italy.

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http://dx.doi.org/10.1038/s41418-018-0170-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461983PMC
May 2019

Molecular Regulation of Carcinogenesis: Friend and Foe.

Toxicol Sci 2018 10;165(2):277-283

Department of Veterinary and Biomedical Sciences, The Center of Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, Pennsylvania 16802.

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http://dx.doi.org/10.1093/toxsci/kfy185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154271PMC
October 2018

Pregnane X Receptor Regulates Liver Size and Liver Cell Fate by Yes-Associated Protein Activation in Mice.

Hepatology 2019 01 17;69(1):343-358. Epub 2018 Dec 17.

Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China.

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http://dx.doi.org/10.1002/hep.30131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324985PMC
January 2019

Aspirin binds to PPARα to stimulate hippocampal plasticity and protect memory.

Proc Natl Acad Sci U S A 2018 07 16;115(31):E7408-E7417. Epub 2018 Jul 16.

Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612;

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http://dx.doi.org/10.1073/pnas.1802021115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077698PMC
July 2018

Glycyrrhizin Alleviates Nonalcoholic Steatohepatitis via Modulating Bile Acids and Meta-Inflammation.

Drug Metab Dispos 2018 09 29;46(9):1310-1319. Epub 2018 Jun 29.

State Key Laboratory of Natural Medicines, Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, Jiangsu, China (Ti. Y., H.W., L.C., G.W., H.H.); and Laboratory of Metabolism, Center for Cancer Research, National Institutes of Health National Cancer Institute, Bethesda, Maryland (Ti. Y., Q.W., S.T., To.Y., G.L., K.W.K., F.J.G.)

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http://dx.doi.org/10.1124/dmd.118.082008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081736PMC
September 2018

In vitrometabolic mapping of neobavaisoflavone in human cytochromes P450 and UDP-glucuronosyltransferase enzymes by ultra high-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry.

J Pharm Biomed Anal 2018 Sep 18;158:351-360. Epub 2018 Jun 18.

College of Pharmacy, Jinan University, Guangzhou 510632, PR China; Guangdong Provincial Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, PR China; Integrated Chinese and Western Medicine Postdoctoral Research Station, Jinan University, Guangzhou 510632, PR China.

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http://dx.doi.org/10.1016/j.jpba.2018.06.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7396963PMC
September 2018

A metabolomic perspective of pazopanib-induced acute hepatotoxicity in mice.

Xenobiotica 2019 Jun 23;49(6):655-670. Epub 2018 Jul 23.

a State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming , China.

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http://dx.doi.org/10.1080/00498254.2018.1489167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628935PMC
June 2019

Metabolic alterations in triptolide-induced acute hepatotoxicity.

Biomed Chromatogr 2018 Oct 4;32(10):e4299. Epub 2018 Jul 4.

National Cancer Institute, National Institutes of Health, Laboratory of Metabolism, Center for Cancer Research, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1002/bmc.4299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150827PMC
October 2018

Adipocyte-derived Lysophosphatidylcholine Activates Adipocyte and Adipose Tissue Macrophage Nod-Like Receptor Protein 3 Inflammasomes Mediating Homocysteine-Induced Insulin Resistance.

EBioMedicine 2018 May 27;31:202-216. Epub 2018 Apr 27.

Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing 100191, People's Republic of China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S23523964183015
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http://dx.doi.org/10.1016/j.ebiom.2018.04.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013933PMC
May 2018

Inhibition of tumorigenesis by peroxisome proliferator-activated receptor (PPAR)-dependent cell cycle blocks in human skin carcinoma cells.

Toxicology 2018 07 3;404-405:25-32. Epub 2018 May 3.

Department of Veterinary and Biomedical Sciences, The Center of Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA 16802, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tox.2018.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026558PMC
July 2018

Inverse association of vitamin D levels with lung cancer mediated by genetic variation.

Cancer Med 2018 06 3;7(6):2764-2775. Epub 2018 May 3.

Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, 20892.

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http://dx.doi.org/10.1002/cam4.1444DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010700PMC
June 2018

Structure-Activity Relationships of the Main Bioactive Constituents of on Aryl Hydrocarbon Receptor Activation and Associated Bile Acid Homeostasis.

Drug Metab Dispos 2018 07 24;46(7):1030-1040. Epub 2018 Apr 24.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (Yo.Z., Ti.Y., D.S. C.X., To.Y., K.W.K., F.J.G.); State Key Laboratory of Natural and Biomimetic Drugs and Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing, China (Yo.Z., Yi.Z., L.Z., X.Y.); Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, Oregon (W.H.B.); and College of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang, Liaoning, China (D.S.)

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http://dx.doi.org/10.1124/dmd.117.080176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003592PMC
July 2018

PPARα Mediates the Hepatoprotective Effects of Nutmeg.

J Proteome Res 2018 05 25;17(5):1887-1897. Epub 2018 Apr 25.

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany , Chinese Academy of Sciences , Kunming 650201 , China.

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http://pubs.acs.org/doi/10.1021/acs.jproteome.7b00901
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http://dx.doi.org/10.1021/acs.jproteome.7b00901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628927PMC
May 2018

Metabolic profiling of corylin in vivo and in vitro.

J Pharm Biomed Anal 2018 Jun 26;155:157-168. Epub 2018 Mar 26.

College of Pharmacy, Jinan University, Guangzhou 510632, PR China; Guangdong Provincial Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, PR China; Integrated Chinese and Western Medicine Postdoctoral research station, Jinan University, Guangzhou 510632, PR China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S07317085173181
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http://dx.doi.org/10.1016/j.jpba.2018.03.047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6666405PMC
June 2018

Intestine farnesoid X receptor agonist and the gut microbiota activate G-protein bile acid receptor-1 signaling to improve metabolism.

Hepatology 2018 10 21;68(4):1574-1588. Epub 2018 May 21.

Department of Integrative Medical Sciences, College of Medicine, Northeast Ohio Medical University, Rootstown, OH.

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http://dx.doi.org/10.1002/hep.29857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6111007PMC
October 2018

Fat-specific protein 27 is a novel target gene of liver X receptor α.

Mol Cell Endocrinol 2018 10 15;474:48-56. Epub 2018 Feb 15.

Faculty of Pharmaceutical Science, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan.

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http://dx.doi.org/10.1016/j.mce.2018.02.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6594021PMC
October 2018

Role of the pregnane X receptor in binge ethanol-induced steatosis and hepatotoxicity.

J Pharmacol Exp Ther 2018 Feb 5. Epub 2018 Feb 5.

North Carolina Central University;

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http://dx.doi.org/10.1124/jpet.117.244665DOI Listing
February 2018

Corrigendum to "Metabolic adaptation to intermittent fasting is independent of peroxisome proliferator-activated receptor alpha" [Mol Metab 7 (2018) 80-89].

Mol Metab 2018 03 2;9:217-219. Epub 2018 Feb 2.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2018.01.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870094PMC
March 2018

Metabolic Profiling of the Novel Hypoxia-Inducible Factor 2 Inhibitor PT2385 In Vivo and In Vitro.

Drug Metab Dispos 2018 04 23;46(4):336-345. Epub 2018 Jan 23.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (C.X., X.G., D.S., Y.Z., K.W.K., F.J.G.); and Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan, Shanxi, People's Republic of China (X.G., X.Q.)

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http://dx.doi.org/10.1124/dmd.117.079723DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829541PMC
April 2018

Effects of disease salience and xenophobia on support for humanitarian aid.

Politics Life Sci 2017 ;36(2):17-36

3University of Nebraska,Lincoln.

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http://dx.doi.org/10.1017/pls.2017.24DOI Listing
October 2018