Publications

Vascular smooth muscle cell peroxisome proliferator-activated receptor γ protects against endothelin-1-induced oxidative stress and inflammation.
J Hypertens 2017 Jul;35(7):1390-1401
aHypertension and Vascular Research Unit, Lady Davis Institute for Medical Research bDepartment of Medicine, Sir Mortimer B. Davis-Jewish General Hospital, McGill University, Montreal, Quebec, Canada cDepartment of Clinical Medicine, State University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil dDepartment of Pharmacology, Max-Planck-Institute for Heart and Lung Research, Bad Nauheim, Germany eLaboratory of Metabolism, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA *Noureddine Idris-Khodja and Sofiane Ouerd contributed equally to the article.

2-Methoxyestradiol Reduces Angiotensin II-Induced Hypertension and Renal Dysfunction in Ovariectomized Female and Intact Male Mice.
Hypertension 2017 Jun 17;69(6):1104-1112. Epub 2017 Apr 17.
From the Department of Pharmacology, College of Medicine, University of Tennessee Health Science Center, Memphis (A.K.P., K.N.D., S.T., N.S.K., K.U.M.); Department of Physiology, Hypertension & Renal Center, School of Medicine, Tulane University, New Orleans, LA (A.K., D.S.A.M., L.G.N.); and Laboratory of Metabolism, National Cancer Institute, Bethesda, MD (F.J.G.).

An HNF4α-microRNA-194/192 signaling axis maintains hepatic cell function.
J Biol Chem 2017 Jun 2;292(25):10574-10585. Epub 2017 May 2.
From the Laboratory of Molecular Life Science, Division of Molecular Science, Faculty of Science and Technology, Gunma University, Kiryu, Gunma 376-8515, Japan,

Role of the lipid-regulated NF-κB/IL-6/STAT3 axis in alpha-naphthyl isothiocyanate-induced liver injury.
Arch Toxicol 2017 May 16;91(5):2235-2244. Epub 2016 Nov 16.
Laboratory of Metabolism, Center for Cancer Research, National Institutes of Health, Building 37, Room 3106, Bethesda, MD, 20892, USA.

Peroxisome proliferator-activated receptor-β/δ inhibits human neuroblastoma cell tumorigenesis by inducing p53- and SOX2-mediated cell differentiation.
Mol Carcinog 2017 May 13;56(5):1472-1483. Epub 2017 Jan 13.
Department of Veterinary and Biomedical Sciences and The Center of Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, Pennsylvania.


Choline Kinase α Mediates Interactions Between the Epidermal Growth Factor Receptor and Mechanistic Target of Rapamycin Complex 2 in Hepatocellular Carcinoma Cells to Promote Drug Resistance and Xenograft Tumor Progression.
Gastroenterology 2017 Apr 5;152(5):1187-1202. Epub 2017 Jan 5.
International Co-operation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Institute, Second Military Medical University, Shanghai, China; National Center for Liver Cancer, Shanghai, China; Mengchao Hepatobiliary Hospital, Fujian Medical University, Fuzhou, China; Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. Electronic address:



Age-dependent PPARα activation induces hepatic sulfatide accumulation in transgenic mice carrying the hepatitis C virus core gene.
Glycoconj J 2016 Dec 18;33(6):927-936. Epub 2016 Jun 18.
Department of Metabolic Regulation, Shinshu University Graduate School of Medicine, Matsumoto, 390-8621, Japan.

Peroxisome proliferator-activated receptor α-dependent renoprotection of murine kidney by irbesartan.
Clin Sci (Lond) 2016 Nov 5;130(21):1969-1981. Epub 2016 Aug 5.
Department of Metabolic Regulation, Institute of Pathogenesis and Disease Prevention, Shinshu University Graduate School of Medicine, 3-1-1, Asahi, Matsumoto, Nagano, 390-8621, Japan.

The antiandrogen flutamide is a novel aryl hydrocarbon receptor ligand that disrupts bile acid homeostasis in mice through induction of Abcc4.
Biochem Pharmacol 2016 Nov 26;119:93-104. Epub 2016 Aug 26.
Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:

Regulation of Cytochrome P450 2B10 (CYP2B10) Expression in Liver by Peroxisome Proliferator-activated Receptor-β/δ Modulation of SP1 Promoter Occupancy.
J Biol Chem 2016 Nov 20;291(48):25255-25263. Epub 2016 Oct 20.
From the Department of Veterinary and Biomedical Sciences and the Center of Molecular Toxicology and Carcinogenesis, Pennsylvania State University, University Park, Pennsylvania 16802,

Farnesoid X Receptor Signaling Shapes the Gut Microbiota and Controls Hepatic Lipid Metabolism.
mSystems 2016 Sep-Oct;1(5). Epub 2016 Oct 11.
Center for Molecular Toxicology and Carcinogenesis, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, Pennsylvania, USA.

Phosphorylation of Farnesoid X Receptor at Serine 154 Links Ligand Activation With Degradation.
Mol Endocrinol 2016 Oct 29;30(10):1070-1080. Epub 2016 Aug 29.
Pharmacogenetics Section (T.H., S.A., T.S., M.N.), Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709; and Laboratory of Metabolism (S.T., F.J.G.), Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892.

Interferon-microRNA signalling drives liver precancerous lesion formation and hepatocarcinogenesis.
Gut 2016 Jul 9;65(7):1186-201. Epub 2016 Feb 9.
International Co-operation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Institute, Second Military Medical University, Shanghai, China National Center for Liver Cancer, Shanghai, China State Key Laboratory for Oncogenes and Related Genes, Cancer Institute of RenJi Hospital, Shanghai JiaoTong University, Shanghai, China.


Ligand activation of peroxisome proliferator-activated receptor-β/δ suppresses liver tumorigenesis in hepatitis B transgenic mice.
Toxicology 2016 Jul 15;363-364:1-9. Epub 2016 Jul 15.
Department of Veterinary and Biomedical Sciences and The Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA, USA. Electronic address:

Urinary Metabolite Risk Biomarkers of Lung Cancer: A Prospective Cohort Study.
Cancer Epidemiol Biomarkers Prev 2016 Jun 24;25(6):978-86. Epub 2016 Mar 24.
Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.

Metabolomics reveals mycoplasma contamination interferes with the metabolism of PANC-1 cells.
Anal Bioanal Chem 2016 Jun 13;408(16):4267-73. Epub 2016 Apr 13.
School of Pharmaceutical Sciences, Sun Yat-sen University, 132# Waihuandong Rd, University City of Guangzhou, Guangzhou, 510006, China.

6β-Hydroxytestosterone, a Cytochrome P450 1B1-Testosterone-Metabolite, Mediates Angiotensin II-Induced Renal Dysfunction in Male Mice.
Hypertension 2016 May 29;67(5):916-26. Epub 2016 Feb 29.
From the Department of Pharmacology (A.K.P., S.T., M.K., K.U.M.) and Department of Medicine and Microbiology, Immunology and Biochemistry (D.D.B.), College of Medicine, University of Tennessee Health Science Center, Memphis; Veterans Affairs Medical Center, Memphis, TN (D.D.B.); Tulane Hypertension and Renal Center of Excellence, Department of Physiology, School of Medicine, Tulane University, New Orleans, LA (A.K., D.S.A.M., L.G.N.); and Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, Bethesda, MD (F.J.G.).

Glycyrrhizin Protects against Acetaminophen-Induced Acute Liver Injury via Alleviating Tumor Necrosis Factor α-Mediated Apoptosis.
Drug Metab Dispos 2016 May 10;44(5):720-31. Epub 2016 Mar 10.
State Key Laboratory of Natural Medicines, Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, Jiangsu, People's Republic of China (Ti.Y., H.W., M.Z., Yi.C., X.C., J.Z., Yu.C., F.L., Y.W., G.W., H.H.); Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (Ti.Y., To.Y., K.W.K., C.X., C.N.B., F.J.G.)

Serum miRNAs as predictive and preventive biomarker for pre-clinical hepatocellular carcinoma.
Cancer Lett 2016 Apr 2;373(2):234-40. Epub 2016 Feb 2.
International Co-operation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Institute, Second Military Medical University, Shanghai 200438, China; National Center for Liver Cancer, Shanghai, China; National Laboratory for Oncogenes and Related Genes, Cancer Institute, RenJi Hospital, Shanghai Jiao Tong University, Shanghai 200441, China. Electronic address:

A lipidomics investigation into the intervention of celastrol in experimental colitis.
Mol Biosyst 2016 Apr;12(5):1436-44
Department of Pharmaceutical Analysis, School of Pharmacy, Second Military Medical University, Shanghai 200433, China. and Department of Pharmaceutical Analysis, School of Pharmacy, Fudan University, Shanghai 201203, China.

HIF2α Is an Essential Molecular Brake for Postprandial Hepatic Glucagon Response Independent of Insulin Signaling.
Cell Metab 2016 Mar 4;23(3):505-16. Epub 2016 Feb 4.
Departments of Molecular & Integrative Physiology, Division of Gastroenterology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Internal Medicine, Division of Gastroenterology, University of Michigan Medical School, Ann Arbor, MI 48109, USA. Electronic address:

Mass Spectrometry-Based Metabolomics Identifies Longitudinal Urinary Metabolite Profiles Predictive of Radiation-Induced Cancer.
Cancer Res 2016 Mar 15;76(6):1569-77. Epub 2016 Feb 15.
Department of Veterinary and Biomedical Sciences and the Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, Pennsylvania.

Antioxidant Drug Tempol Promotes Functional Metabolic Changes in the Gut Microbiota.
J Proteome Res 2016 Feb 12;15(2):563-71. Epub 2016 Jan 12.
Center for Molecular Toxicology and Carcinogenesis, Department of Veterinary and Biomedical Sciences, Pennsylvania State University , University Park, State College, Pennsylvania 16802, United States.

Cytochrome P450 1B1 Contributes to the Development of Atherosclerosis and Hypertension in Apolipoprotein E-Deficient Mice.
Hypertension 2016 Jan 16;67(1):206-13. Epub 2015 Nov 16.
From the Department of Pharmacology (C.Y.S., K.G., H.U.G., N.S.K., S.T., B.L.J., A.M.E., S.Z., K.U.M.) and Department of Physiology and Pediatrics (D.B.), College of Medicine, University of Tennessee Health Science Center, Memphis; Department of Pathobiology and Molecular Medicine, University of Cincinnati, OH (P.T.); and Center for Cancer Research, Laboratory of Metabolism, National Cancer Institute, Bethesda, MD (F.J.G.).

Irinotecan (CPT-11)-induced elevation of bile acids potentiates suppression of IL-10 expression.
Toxicol Appl Pharmacol 2016 Jan 17;291:21-7. Epub 2015 Dec 17.
Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. Electronic address:

Deletion of ARNT/HIF1β in pancreatic beta cells does not impair glucose homeostasis in mice, but is associated with defective glucose sensing ex vivo.
Diabetologia 2015 Dec 26;58(12):2832-42. Epub 2015 Sep 26.
School of Pharmacy, University of Waterloo, Health Science Campus building A, room 4008, 10A Victoria Street South, Kitchener, ON, Canada, N2G 1C5.

Hepatocyte Nuclear Factor 4α Controls Iron Metabolism and Regulates Transferrin Receptor 2 in Mouse Liver.
J Biol Chem 2015 Dec 2;290(52):30855-65. Epub 2015 Nov 2.
From the Division of Molecular Science, Graduate School of Science and Technology, Gunma University, Kiryu, Gunma 376-8515, Japan,

Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction.
Nat Commun 2015 Dec 15;6:10166. Epub 2015 Dec 15.
Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

Inhibition of testicular embryonal carcinoma cell tumorigenicity by peroxisome proliferator-activated receptor-β/δ- and retinoic acid receptor-dependent mechanisms.
Oncotarget 2015 Nov;6(34):36319-37
Department of Veterinary and Biomedical Sciences, The Center of Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, Pennsylvania, USA.

Fat-Specific Protein 27/CIDEC Promotes Development of Alcoholic Steatohepatitis in Mice and Humans.
Gastroenterology 2015 Oct 20;149(4):1030-41.e6. Epub 2015 Jun 20.
Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland. Electronic address:

Exposure to ionizing radiation reveals global dose- and time-dependent changes in the urinary metabolome of rat.
Metabolomics 2015 Oct 20;11(5):1082-1094. Epub 2014 Dec 20.
Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC ; Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center, Washington, DC.

Pregnane X Receptor-Humanized Mice Recapitulate Gender Differences in Ethanol Metabolism but Not Hepatotoxicity.
J Pharmacol Exp Ther 2015 Sep 9;354(3):459-70. Epub 2015 Jul 9.
Julius L. Chambers Biomedical/Biotechnology Research Institute, North Carolina Central University, Durham, North Carolina (K.S., A.A.G., S.T.Y., R.M.R., M.A.G.); and Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland (F.J.G.)

Peroxisome Proliferator-activated Receptor-D (PPARD) Coordinates Mouse Spermatogenesis by Modulating Extracellular Signal-regulated Kinase (ERK)-dependent Signaling.
J Biol Chem 2015 Sep 4;290(38):23416-31. Epub 2015 Aug 4.
From the Department of Veterinary and Biomedical Sciences and The Center of Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, Pennsylvania 16802,

Maternal bile acid transporter deficiency promotes neonatal demise.
Nat Commun 2015 Sep 29;6:8186. Epub 2015 Sep 29.
Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA.

Epigenetic control of EMT/MET dynamics: HNF4α impacts DNMT3s through miRs-29.
Biochim Biophys Acta 2015 Aug 21;1849(8):919-29. Epub 2015 May 21.
Istituto Pasteur-Fondazione Cenci Bolognetti, Department of Cellular Biotechnologies and Hematology, Section of Molecular Genetics, Sapienza University of Rome, Rome, Italy; National Institute for Infectious Diseases L. Spallanzani, IRCCS, Rome, Italy. Electronic address:

Transcriptome Analysis of K-877 (a Novel Selective PPARα Modulator (SPPARMα))-Regulated Genes in Primary Human Hepatocytes and the Mouse Liver.
J Atheroscler Thromb 2015 Aug 4;22(8):754-72. Epub 2015 Jun 4.
Laboratory for Systems Biology and Medicine (LSBM), Research Center for Advanced Science and Technology (RCAST), University of Tokyo.

HMG-CoA Reductase Inhibitors Bind to PPARα to Upregulate Neurotrophin Expression in the Brain and Improve Memory in Mice.
Cell Metab 2015 Aug 25;22(2):253-65. Epub 2015 Jun 25.
Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA; Division of Research and Development, Jesse Brown Veterans Affairs Medical Center, 820 South Darnen Avenue, Chicago, IL 60612, USA. Electronic address:

Persistent Organic Pollutants Modify Gut Microbiota-Host Metabolic Homeostasis in Mice Through Aryl Hydrocarbon Receptor Activation.
Environ Health Perspect 2015 Jul 13;123(7):679-88. Epub 2015 Mar 13.
Center for Molecular Toxicology and Carcinogenesis, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, Pennsylvania, USA.

6β-hydroxytestosterone, a cytochrome P450 1B1 metabolite of testosterone, contributes to angiotensin II-induced hypertension and its pathogenesis in male mice.
Hypertension 2015 Jun 13;65(6):1279-87. Epub 2015 Apr 13.
From the Department of Pharmacology, College of Medicine (A.K.P., M.K., N.S.K., A.M.E., K.U.M.) and Department of Pharmaceutical Sciences, College of Pharmacy (Z.L., W.L.), University of Tennessee, Health Science Center, Memphis; and Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, Bethesda, MD (F.J.G.).

Activation of peroxisome proliferator-activated receptor α induces lysosomal biogenesis in brain cells: implications for lysosomal storage disorders.
J Biol Chem 2015 Apr 6;290(16):10309-24. Epub 2015 Mar 6.
From the Departments of Neurological Sciences and the Division of Research and Development, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois 60612

OF