Frank J Gonzalez

Frank J Gonzalez

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Adrenoceptor-related decrease in serum triglycerides is independent of PPARα activation.

FEBS J 2019 Nov 28;286(21):4328-4341. Epub 2019 Jun 28.

Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1111/febs.14966DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829030PMC
November 2019

Withaferin A Improves Nonalcoholic Steatohepatitis in Mice.

J Pharmacol Exp Ther 2019 Nov 16;371(2):360-374. Epub 2019 Aug 16.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (D.P.P., T.Y., D.K., H.B.D., K.W.K., S.K., F.J.G.) and Laboratory of Cellular Biophysics and Inflammation, Pontifical Catholic University of Rio Grande do Sul, Rio Grande do Sul, Brazil (H.B.D.)

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http://dx.doi.org/10.1124/jpet.119.256792DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800446PMC
November 2019

Hepatocyte peroxisome proliferator-activated receptor α regulates bile acid synthesis and transport.

Biochim Biophys Acta Mol Cell Biol Lipids 2019 Oct 10;1864(10):1396-1411. Epub 2019 Jun 10.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 2089, United States of America. Electronic address:

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http://dx.doi.org/10.1016/j.bbalip.2019.05.014DOI Listing
October 2019

Parkin is transcriptionally regulated by the aryl hydrocarbon receptor: Impact on α-synuclein protein levels.

Biochem Pharmacol 2019 Oct 9;168:429-437. Epub 2019 Aug 9.

Departamento de Biología Celular, CINVESTAV-IPN, Av. IPN 2508, C.P. 07360 Ciudad de México, Mexico. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2019.08.002DOI Listing
October 2019

Metabolic Activation of Elemicin Leads to the Inhibition of Stearoyl-CoA Desaturase 1.

Chem Res Toxicol 2019 Oct 10;32(10):1965-1976. Epub 2019 Sep 10.

States Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany , Chinese Academy of Sciences , Kunming 650201 , China.

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http://dx.doi.org/10.1021/acs.chemrestox.9b00112DOI Listing
October 2019

Unraveling the role of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) expression in colon carcinogenesis.

NPJ Precis Oncol 2019 7;3:26. Epub 2019 Oct 7.

3Laboratory of Metabolism, National Cancer Institute, Bethesda, MD USA.

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http://dx.doi.org/10.1038/s41698-019-0098-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779880PMC
October 2019

A multiparametric organ toxicity predictor for drug discovery.

Toxicol Mech Methods 2019 Oct 29:1-8. Epub 2019 Oct 29.

Department of Botany, Bioinformatics and Climate Change Impacts Management, University School of Sciences, Gujarat University, Ahmedabad, India.

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http://dx.doi.org/10.1080/15376516.2019.1681044DOI Listing
October 2019

Propranolol is a mechanism-based inhibitor of CYP2D and CYP2D6 in humanized CYP2D6-transgenic mice: effects on activity and drug response.

Br J Pharmacol 2019 Oct 24. Epub 2019 Oct 24.

Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Department of Pharmacology & Toxicology, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1111/bph.14884DOI Listing
October 2019

Regulatory mechanisms mediated by peroxisome proliferator-activated receptor-β/δ in skin cancer.

Mol Carcinog 2019 09 6;58(9):1612-1622. Epub 2019 May 6.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.

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http://dx.doi.org/10.1002/mc.23033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6692234PMC
September 2019

Intestinal PPARα Protects Against Colon Carcinogenesis via Regulation of Methyltransferases DNMT1 and PRMT6.

Gastroenterology 2019 09 30;157(3):744-759.e4. Epub 2019 May 30.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00165085194097
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http://dx.doi.org/10.1053/j.gastro.2019.05.057DOI Listing
September 2019

Non-targeted metabolomics reveals diagnostic biomarker in the tongue coating of patients with chronic gastritis.

J Pharm Biomed Anal 2019 Sep 20;174:541-551. Epub 2019 Jun 20.

Hebei Province Hospital of Traditional Chinese Medicine, Shijiazhuang, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.jpba.2019.06.025DOI Listing
September 2019

Publisher Correction: Gut microbiota-bile acid-interleukin-22 axis orchestrates polycystic ovary syndrome.

Nat Med 2019 Sep;25(9):1459

Department of Obstetrics and Gynecology, Center for Obesity and Metabolic Disease Research, School of Basic Medical Sciences, Third Hospital, Peking University, Beijing, China.

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http://www.nature.com/articles/s41591-019-0562-8
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http://dx.doi.org/10.1038/s41591-019-0562-8DOI Listing
September 2019

The essential role of the transporter ABCG2 in the pathophysiology of erythropoietic protoporphyria.

Sci Adv 2019 Sep 18;5(9):eaaw6127. Epub 2019 Sep 18.

Center for Pharmacogenetics, Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA.

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http://dx.doi.org/10.1126/sciadv.aaw6127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750912PMC
September 2019

Gut microbiota-bile acid-interleukin-22 axis orchestrates polycystic ovary syndrome.

Nat Med 2019 08 22;25(8):1225-1233. Epub 2019 Jul 22.

Department of Obstetrics and Gynecology, Center for Obesity and Metabolic Disease Research, School of Basic Medical Sciences, Third Hospital, Peking University, Beijing, China.

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http://dx.doi.org/10.1038/s41591-019-0509-0DOI Listing
August 2019

Dietary Intake Regulates the Circulating Inflammatory Monocyte Pool.

Cell 2019 Aug;178(5):1102-1114.e17

Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA; The Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.07.050DOI Listing
August 2019

Keratin 23 Is a Peroxisome Proliferator-Activated Receptor Alpha-Dependent, MYC-Amplified Oncogene That Promotes Hepatocyte Proliferation.

Hepatology 2019 Jul 20;70(1):154-167. Epub 2019 Mar 20.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD.

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http://dx.doi.org/10.1002/hep.30530DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597269PMC
July 2019

Impaired clearance of sunitinib leads to metabolic disorders and hepatotoxicity.

Br J Pharmacol 2019 Jul 7;176(13):2162-2178. Epub 2019 May 7.

State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China.

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http://dx.doi.org/10.1111/bph.14664DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555861PMC
July 2019

Role of Metabolic Activation in Elemicin-Induced Cellular Toxicity.

J Agric Food Chem 2019 Jul 16;67(29):8243-8252. Epub 2019 Jul 16.

State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China.

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http://dx.doi.org/10.1021/acs.jafc.9b02137DOI Listing
July 2019

A trans-fatty acid-rich diet promotes liver tumorigenesis in HCV core gene transgenic mice.

Carcinogenesis 2019 Jul 12. Epub 2019 Jul 12.

Department of Metabolic Regulation, Shinshu University School of Medicine, Matsumoto, Japan.

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http://dx.doi.org/10.1093/carcin/bgz132DOI Listing
July 2019

Hypoxia inducible factor 1α in vascular smooth muscle cells promotes angiotensin II-induced vascular remodeling via activation of CCL7-mediated macrophage recruitment.

Cell Death Dis 2019 Jul 18;10(8):544. Epub 2019 Jul 18.

Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University; Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education, Beijing, China.

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http://dx.doi.org/10.1038/s41419-019-1757-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639417PMC
July 2019

A metabolomic perspective of pazopanib-induced acute hepatotoxicity in mice.

Xenobiotica 2019 Jun 23;49(6):655-670. Epub 2018 Jul 23.

a State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming , China.

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http://dx.doi.org/10.1080/00498254.2018.1489167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628935PMC
June 2019

Adrenoceptor-stimulated inflammatory response in stress-induced serum amyloid A synthesis.

Psychopharmacology (Berl) 2019 Jun 6;236(6):1687-1699. Epub 2019 Jan 6.

Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1007/s00213-018-5149-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6643287PMC
June 2019

The Protective Roles of PPARα Activation in Triptolide-induced Liver Injury.

Toxicol Sci 2019 Jun 26. Epub 2019 Jun 26.

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China.

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http://dx.doi.org/10.1093/toxsci/kfz146DOI Listing
June 2019

The lncRNA HOTAIR transcription is controlled by HNF4α-induced chromatin topology modulation.

Cell Death Differ 2019 May 28;26(5):890-901. Epub 2018 Aug 28.

Istituto Pasteur-Fondazione Cenci Bolognetti, Department of Cellular Biotechnologies and Haematology, Sapienza University of Rome, Rome, Italy.

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http://dx.doi.org/10.1038/s41418-018-0170-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461983PMC
May 2019

β Cell Hypoxia-Inducible Factor-1α Is Required for the Prevention of Type 1 Diabetes.

Cell Rep 2019 May;27(8):2370-2384.e6

Center for Diabetes, Obesity, and Endocrinology (CDOE), The Westmead Institute for Medical Research (WIMR), The University of Sydney, Sydney, NSW, Australia; Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia; St Vincent's Clinical School, University of New South Wales, Kensington, NSW, Australia; Department of Diabetes and Endocrinology, Westmead Hospital, Sydney, NSW, Australia. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247193056
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http://dx.doi.org/10.1016/j.celrep.2019.04.086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6661122PMC
May 2019

Hepatic metabolic adaptation in a murine model of glutathione deficiency.

Chem Biol Interact 2019 Apr 20;303:1-6. Epub 2019 Feb 20.

Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT, 06520, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cbi.2019.02.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743730PMC
April 2019

Pregnane X receptor activation potentiates ritonavir hepatotoxicity.

J Clin Invest 2019 04 30;129(7):2898-2903. Epub 2019 Apr 30.

Center for Pharmacogenetics, Department of Pharmaceutical Sciences, School of Pharmacy, and.

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http://www.jci.org/articles/view/128274
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http://dx.doi.org/10.1172/JCI128274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597219PMC
April 2019

Endothelial Cell-Targeted Deletion of PPAR Blocks Rosiglitazone-Induced Plasma Volume Expansion and Vascular Remodeling in Adipose Tissue.

J Pharmacol Exp Ther 2019 03 3;368(3):514-523. Epub 2019 Jan 3.

Cardiometabolic Disorders Department, Merck Research Laboratories, Kenilworth, New Jersey (T.E.A., L.A.M., N.S., E.I.Z., H.L., J.W.W., C.H.C., J.P.B.); Department of Pathology and Molecular Medicine (G.E.S.-G., E.D.L., C.J.B.N.), Cancer Biology and Genetics Division, Cancer Research Institute (R.E.R., C.J.B.N.), and Department of Biomedical and Molecular Sciences (J.Y.S., C.J.B.N.), Queen's University, Kingston, Ontario, Canada; National Cancer Institute, National Institutes of Health, Bethesda, Maryland (F.J.G.); and Takeda Pharmaceuticals International, Inc., Cambridge, Massachusetts (J.P.B.)

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http://dx.doi.org/10.1124/jpet.118.250985DOI Listing
March 2019

Celastrol Protects From Cholestatic Liver Injury Through Modulation of SIRT1-FXR Signaling.

Mol Cell Proteomics 2019 03 7;18(3):520-533. Epub 2019 Jan 7.

From the ‡State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;

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http://dx.doi.org/10.1074/mcp.RA118.000817DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398203PMC
March 2019

A systemic workflow for profiling metabolome and lipidome in tissue.

J Chromatogr A 2019 Mar 30;1589:105-115. Epub 2018 Dec 30.

School of Public Health/MOE Key Lab for Public Health, Fudan University, Shanghai, 200032, China. Electronic address:

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http://dx.doi.org/10.1016/j.chroma.2018.12.061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628932PMC
March 2019

In utero exposure to di(2-ethylhexyl)phthalate suppresses blood glucose and leptin levels in the offspring of wild-type mice.

Toxicology 2019 03 17;415:49-55. Epub 2019 Jan 17.

College of Life and Health Sciences, Chubu University, 1200 Matsumoto-cho, Kasugai, Aichi, 487-8501, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.tox.2019.01.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628919PMC
March 2019

Modulation of Lipid Metabolism by Celastrol.

J Proteome Res 2019 Mar 12;18(3):1133-1144. Epub 2019 Feb 12.

State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China.

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http://pubs.acs.org/doi/10.1021/acs.jproteome.8b00797
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http://dx.doi.org/10.1021/acs.jproteome.8b00797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6626529PMC
March 2019

Bioengineered miRNA-1291 prodrug therapy in pancreatic cancer cells and patient-derived xenograft mouse models.

Cancer Lett 2019 02 30;442:82-90. Epub 2018 Oct 30.

Department of Biochemistry & Molecular Medicine, UC Davis School of Medicine, Sacramento, CA, 95817, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03043835183065
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http://dx.doi.org/10.1016/j.canlet.2018.10.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311422PMC
February 2019

Hepatocyte Peroxisome Proliferator-Activated Receptor α Enhances Liver Regeneration after Partial Hepatectomy in Mice.

Am J Pathol 2019 02 16;189(2):272-282. Epub 2018 Nov 16.

Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education, Capital Medical University, Beijing, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00029440183019
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http://dx.doi.org/10.1016/j.ajpath.2018.10.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593252PMC
February 2019

Pregnane X Receptor Regulates Liver Size and Liver Cell Fate by Yes-Associated Protein Activation in Mice.

Hepatology 2019 Jan 17;69(1):343-358. Epub 2018 Dec 17.

Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China.

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http://dx.doi.org/10.1002/hep.30131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324985PMC
January 2019

Peroxisome proliferator-activated receptor α attenuates high-cholesterol diet-induced toxicity and pro-thrombotic effects in mice.

Arch Toxicol 2019 01 19;93(1):149-161. Epub 2018 Oct 19.

Department of Metabolic Regulation, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, Japan.

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http://dx.doi.org/10.1007/s00204-018-2335-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6661123PMC
January 2019

Induction of Hepatic Metabolic Functions by a Novel Variant of Hepatocyte Nuclear Factor 4γ.

Mol Cell Biol 2018 12 28;38(24). Epub 2018 Nov 28.

Division of Molecular Science, Graduate School of Science and Technology, Gunma University, Kiryu, Gunma, Japan

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http://dx.doi.org/10.1128/MCB.00213-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275183PMC
December 2018

The roles of breast cancer resistance protein (BCRP/ABCG2) and multidrug resistance-associated proteins (MRPs/ABCCs) in the excretion of cycloicaritin-3-O-glucoronide in UGT1A1-overexpressing HeLa cells.

Chem Biol Interact 2018 Dec 17;296:45-56. Epub 2018 Sep 17.

College of Pharmacy, Jinan University, Guangzhou, 510632, PR China; Guangdong Provincial Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632, PR China.

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http://dx.doi.org/10.1016/j.cbi.2018.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628920PMC
December 2018

The role of hypoxia-inducible factors in metabolic diseases.

Nat Rev Endocrinol 2018 12;15(1):21-32

Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China.

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http://dx.doi.org/10.1038/s41574-018-0096-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6624429PMC
December 2018

Gut microbiota and intestinal FXR mediate the clinical benefits of metformin.

Nat Med 2018 12 5;24(12):1919-1929. Epub 2018 Nov 5.

Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, and the Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China.

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http://www.nature.com/articles/s41591-018-0222-4
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http://dx.doi.org/10.1038/s41591-018-0222-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6479226PMC
December 2018

Role of Farnesoid X Receptor and Bile Acids in Hepatic Tumor Development.

Hepatol Commun 2018 Dec 1;2(12):1567-1582. Epub 2018 Oct 1.

Laboratory of Metabolism National Cancer Institute, National Institutes of Health Bethesda MD.

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http://dx.doi.org/10.1002/hep4.1263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287584PMC
December 2018

Pharmacophore-based virtual screening of catechol-o-methyltransferase (COMT) inhibitors to combat Alzheimer's disease.

J Biomol Struct Dyn 2018 Nov 27;36(15):3938-3957. Epub 2017 Dec 27.

a Department of Botany, Bioinformatics and Climate Change Impacts Management , University School of Sciences, Gujarat University , Ahmedabad 380 009 , Gujarat , India.

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http://dx.doi.org/10.1080/07391102.2017.1404931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371058PMC
November 2018

Extrahepatic PPARα modulates fatty acid oxidation and attenuates fasting-induced hepatosteatosis in mice.

J Lipid Res 2018 11 29;59(11):2140-2152. Epub 2018 Aug 29.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892

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http://www.jlr.org/lookup/doi/10.1194/jlr.M088419
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http://dx.doi.org/10.1194/jlr.M088419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210912PMC
November 2018

Noncanonical farnesoid X receptor signaling inhibits apoptosis and impedes liver fibrosis.

EBioMedicine 2018 Nov 15;37:322-333. Epub 2018 Oct 15.

State Key Laboratory of Natural Medicines, Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, China. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2018.10.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286639PMC
November 2018

Effects of disease salience and xenophobia on support for humanitarian aid.

Politics Life Sci 2017 ;36(2):17-36

3University of Nebraska,Lincoln.

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http://dx.doi.org/10.1017/pls.2017.24DOI Listing
October 2018

Fat-specific protein 27 is a novel target gene of liver X receptor α.

Mol Cell Endocrinol 2018 10 15;474:48-56. Epub 2018 Feb 15.

Faculty of Pharmaceutical Science, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan.

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http://dx.doi.org/10.1016/j.mce.2018.02.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6594021PMC
October 2018

Intestine farnesoid X receptor agonist and the gut microbiota activate G-protein bile acid receptor-1 signaling to improve metabolism.

Hepatology 2018 10 21;68(4):1574-1588. Epub 2018 May 21.

Department of Integrative Medical Sciences, College of Medicine, Northeast Ohio Medical University, Rootstown, OH.

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http://dx.doi.org/10.1002/hep.29857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6111007PMC
October 2018

Metabolic alterations in triptolide-induced acute hepatotoxicity.

Biomed Chromatogr 2018 Oct 4;32(10):e4299. Epub 2018 Jul 4.

National Cancer Institute, National Institutes of Health, Laboratory of Metabolism, Center for Cancer Research, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1002/bmc.4299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150827PMC
October 2018

Molecular Regulation of Carcinogenesis: Friend and Foe.

Toxicol Sci 2018 10;165(2):277-283

Department of Veterinary and Biomedical Sciences, The Center of Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, Pennsylvania 16802.

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http://dx.doi.org/10.1093/toxsci/kfy185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154271PMC
October 2018

The Evolution of Carcinogenesis.

Toxicol Sci 2018 10;165(2):272-276

Laboratory of Metabolism, National Cancer Institute, Bethesda, Maryland 20892.

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http://dx.doi.org/10.1093/toxsci/kfy184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154269PMC
October 2018

In vitrometabolic mapping of neobavaisoflavone in human cytochromes P450 and UDP-glucuronosyltransferase enzymes by ultra high-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry.

J Pharm Biomed Anal 2018 Sep 18;158:351-360. Epub 2018 Jun 18.

College of Pharmacy, Jinan University, Guangzhou 510632, PR China; Guangdong Provincial Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, PR China; Integrated Chinese and Western Medicine Postdoctoral Research Station, Jinan University, Guangzhou 510632, PR China.

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http://dx.doi.org/10.1016/j.jpba.2018.06.022DOI Listing
September 2018

Glycyrrhizin Alleviates Nonalcoholic Steatohepatitis via Modulating Bile Acids and Meta-Inflammation.

Drug Metab Dispos 2018 09 29;46(9):1310-1319. Epub 2018 Jun 29.

State Key Laboratory of Natural Medicines, Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, Jiangsu, China (Ti. Y., H.W., L.C., G.W., H.H.); and Laboratory of Metabolism, Center for Cancer Research, National Institutes of Health National Cancer Institute, Bethesda, Maryland (Ti. Y., Q.W., S.T., To.Y., G.L., K.W.K., F.J.G.)

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http://dx.doi.org/10.1124/dmd.118.082008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081736PMC
September 2018

Structure-Activity Relationships of the Main Bioactive Constituents of on Aryl Hydrocarbon Receptor Activation and Associated Bile Acid Homeostasis.

Drug Metab Dispos 2018 07 24;46(7):1030-1040. Epub 2018 Apr 24.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (Yo.Z., Ti.Y., D.S. C.X., To.Y., K.W.K., F.J.G.); State Key Laboratory of Natural and Biomimetic Drugs and Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing, China (Yo.Z., Yi.Z., L.Z., X.Y.); Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, Oregon (W.H.B.); and College of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang, Liaoning, China (D.S.)

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http://dx.doi.org/10.1124/dmd.117.080176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003592PMC
July 2018

Inhibition of tumorigenesis by peroxisome proliferator-activated receptor (PPAR)-dependent cell cycle blocks in human skin carcinoma cells.

Toxicology 2018 07 3;404-405:25-32. Epub 2018 May 3.

Department of Veterinary and Biomedical Sciences, The Center of Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA 16802, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tox.2018.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026558PMC
July 2018

Aspirin binds to PPARα to stimulate hippocampal plasticity and protect memory.

Proc Natl Acad Sci U S A 2018 07 16;115(31):E7408-E7417. Epub 2018 Jul 16.

Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612;

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http://dx.doi.org/10.1073/pnas.1802021115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077698PMC
July 2018

Metabolic profiling of corylin in vivo and in vitro.

J Pharm Biomed Anal 2018 Jun 26;155:157-168. Epub 2018 Mar 26.

College of Pharmacy, Jinan University, Guangzhou 510632, PR China; Guangdong Provincial Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, PR China; Integrated Chinese and Western Medicine Postdoctoral research station, Jinan University, Guangzhou 510632, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.jpba.2018.03.047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6666405PMC
June 2018

Inverse association of vitamin D levels with lung cancer mediated by genetic variation.

Cancer Med 2018 06 3;7(6):2764-2775. Epub 2018 May 3.

Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, 20892.

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http://dx.doi.org/10.1002/cam4.1444DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010700PMC
June 2018

Hepatic peroxisome proliferator-activated receptor alpha mediates the major metabolic effects of Wy-14643.

J Gastroenterol Hepatol 2018 May 19;33(5):1138-1145. Epub 2018 Feb 19.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1111/jgh.14046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334298PMC
May 2018

Simultaneous determination of etonogestrel and ethinyl estradiol in human plasma by UPLC-MS/MS and its pharmacokinetic study.

Biomed Chromatogr 2018 May 19;32(5):e4165. Epub 2018 Jan 19.

Department of Chemistry, School of Sciences, Gujarat University, Ahmedabad, Gujarat, India.

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http://dx.doi.org/10.1002/bmc.4165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6643291PMC
May 2018

PPARα Mediates the Hepatoprotective Effects of Nutmeg.

J Proteome Res 2018 05 25;17(5):1887-1897. Epub 2018 Apr 25.

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany , Chinese Academy of Sciences , Kunming 650201 , China.

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http://pubs.acs.org/doi/10.1021/acs.jproteome.7b00901
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http://dx.doi.org/10.1021/acs.jproteome.7b00901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628927PMC
May 2018

Adipocyte-derived Lysophosphatidylcholine Activates Adipocyte and Adipose Tissue Macrophage Nod-Like Receptor Protein 3 Inflammasomes Mediating Homocysteine-Induced Insulin Resistance.

EBioMedicine 2018 May 27;31:202-216. Epub 2018 Apr 27.

Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing 100191, People's Republic of China. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2018.04.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013933PMC
May 2018

Metabolic Profiling of the Novel Hypoxia-Inducible Factor 2 Inhibitor PT2385 In Vivo and In Vitro.

Drug Metab Dispos 2018 04 23;46(4):336-345. Epub 2018 Jan 23.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (C.X., X.G., D.S., Y.Z., K.W.K., F.J.G.); and Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan, Shanxi, People's Republic of China (X.G., X.Q.)

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http://dx.doi.org/10.1124/dmd.117.079723DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829541PMC
April 2018

Distinct role of nuclear receptor corepressor 1 regulated de novo fatty acids synthesis in liver regeneration and hepatocarcinogenesis in mice.

Hepatology 2018 03 26;67(3):1071-1087. Epub 2018 Jan 26.

The International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China.

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http://dx.doi.org/10.1002/hep.29562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6661113PMC
March 2018

Chemical inhibition and stable knock-down of efflux transporters leads to reduced glucuronidation of wushanicaritin in UGT1A1-overexpressing HeLa cells: the role of breast cancer resistance protein (BCRP) and multidrug resistance-associated proteins (MRPs) in the excretion of glucuronides.

Food Funct 2018 Mar 10;9(3):1410-1423. Epub 2018 Jan 10.

College of Pharmacy, Jinan University, Guangzhou 510632, P. R. China. and Guangdong Provincial Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, P. R. China. and Integrated Chinese and Western Medicine Postdoctoral Research Station, Jinan University, Guangzhou 510632, P. R. China and Guangzhou Research and Creativity Biotechnology Co. Ltd, Guangzhou, 510663, P. R. China.

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http://dx.doi.org/10.1039/c7fo01298eDOI Listing
March 2018

Corrigendum to "Metabolic adaptation to intermittent fasting is independent of peroxisome proliferator-activated receptor alpha" [Mol Metab 7 (2018) 80-89].

Mol Metab 2018 03 2;9:217-219. Epub 2018 Feb 2.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2018.01.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870094PMC
March 2018

Role of the pregnane X receptor in binge ethanol-induced steatosis and hepatotoxicity.

J Pharmacol Exp Ther 2018 Feb 5. Epub 2018 Feb 5.

North Carolina Central University;

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http://dx.doi.org/10.1124/jpet.117.244665DOI Listing
February 2018

Pregnane X receptor promotes ethanol-induced hepatosteatosis in mice.

J Biol Chem 2018 01 9;293(1):1-17. Epub 2017 Nov 9.

From the Julius L. Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, North Carolina 27707,

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http://dx.doi.org/10.1074/jbc.M117.815217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766906PMC
January 2018

Metabolic adaptation to intermittent fasting is independent of peroxisome proliferator-activated receptor alpha.

Mol Metab 2018 01 6;7:80-89. Epub 2017 Nov 6.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2017.10.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784329PMC
January 2018

Growth arrest and DNA damage-inducible 45α protects against nonalcoholic steatohepatitis induced by methionine- and choline-deficient diet.

Biochim Biophys Acta Mol Basis Dis 2017 12 24;1863(12):3170-3182. Epub 2017 Aug 24.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2017.08.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5675002PMC
December 2017

TCDD induces UbcH7 expression and synphilin-1 protein degradation in the mouse ventral midbrain.

J Biochem Mol Toxicol 2017 Oct 16;31(10). Epub 2017 Jun 16.

Departamento de Biología Celular, CINVESTAV-IPN, México D.F, México.

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http://dx.doi.org/10.1002/jbt.21947DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309283PMC
October 2017

Inhibitory effects of fifteen phthalate esters in human cDNA-expressed UDP-glucuronosyltransferase supersomes.

Chemosphere 2017 Oct 19;185:983-990. Epub 2017 Jul 19.

Department of Toxicology, School of Public Health, Tianjin Medical University, 22 Qixiangtai Road, Heping District, Tianjin, China. Electronic address:

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http://dx.doi.org/10.1016/j.chemosphere.2017.07.105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331009PMC
October 2017

A Western diet-induced mouse model reveals a possible mechanism by which metformin decreases obesity.

Eur J Clin Pharmacol 2017 Oct 22;73(10):1337-1339. Epub 2017 Aug 22.

Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, and the Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, People's Republic of China.

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http://dx.doi.org/10.1007/s00228-017-2322-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5693664PMC
October 2017

Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota.

Cell Metab 2017 Oct 14;26(4):672-685.e4. Epub 2017 Sep 14.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2017.08.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668683PMC
October 2017

Editor's Highlight: PPARβ/δ and PPARγ Inhibit Melanoma Tumorigenicity by Modulating Inflammation and Apoptosis.

Toxicol Sci 2017 10;159(2):436-448

Department of Veterinary and Biomedical Sciences, The Center of Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, Pennsylvania 16802.

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http://dx.doi.org/10.1093/toxsci/kfx147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837686PMC
October 2017

Lack of epithelial PPARγ causes cystic adenomatoid malformations in mouse fetal lung.

Biochem Biophys Res Commun 2017 09 21;491(2):271-276. Epub 2017 Jul 21.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.bbrc.2017.07.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291199PMC
September 2017

Orthogonal Comparison of GC-MS and H NMR Spectroscopy for Short Chain Fatty Acid Quantitation.

Anal Chem 2017 08 12;89(15):7900-7906. Epub 2017 Jul 12.

Center for Molecular Toxicology and Carcinogenesis, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University , University Park, Pennsylvania 16802, United States.

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http://dx.doi.org/10.1021/acs.analchem.7b00848DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334302PMC
August 2017

ISN Forefronts Symposium 2015: Nuclear Receptors and Diabetic Nephropathy.

Kidney Int Rep 2016 Sep 5;1(3):177-188. Epub 2016 Aug 5.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.

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http://dx.doi.org/10.1016/j.ekir.2016.07.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601313PMC
September 2016