Frank J Giordano

Frank J Giordano

UNVERIFIED PROFILE

Are you Frank J Giordano?   Register this Author

Register author
Frank J Giordano

Frank J Giordano

Publications by authors named "Frank J Giordano"

Are you Frank J Giordano?   Register this Author

53Publications

813Reads

21Profile Views

Polycystin 2-dependent cardio-protective mechanisms revealed by cardiac stress.

Pflugers Arch 2017 11 31;469(11):1507-1517. Epub 2017 Jul 31.

Department of Pharmacology, School of Medicine, Yale University, 333 Cedar St, New Haven, CT, 06520, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00424-017-2042-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5792378PMC
November 2017

Endothelial HIF-1α Enables Hypothalamic Glucose Uptake to Drive POMC Neurons.

Diabetes 2017 06 14;66(6):1511-1520. Epub 2017 Mar 14.

Program in Integrative Cell Signaling and Neurobiology of Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/db16-1106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440016PMC
June 2017

A Remote Role for Renalase.

EBioMedicine 2016 Jul 25;9:27-28. Epub 2016 Jun 25.

Department of Medicine, Section of Nephrology, Yale University School of Medicine, United States. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ebiom.2016.06.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972559PMC
July 2016

Endothelial Nogo-B regulates sphingolipid biosynthesis to promote pathological cardiac hypertrophy during chronic pressure overload.

JCI Insight 2016 Apr;1(5)

Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, Cornell University, New York, New York, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1172/jci.insight.85484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855879PMC
April 2016

Smooth Muscle Hypoxia-Inducible Factor 1α Links Intravascular Pressure and Atherosclerosis--Brief Report.

Arterioscler Thromb Vasc Biol 2016 Mar 21;36(3):442-5. Epub 2016 Jan 21.

From the Departments of Medicine (D.L., L.L., M.D., Y.H., J.C., W.J., F.J.G.) and Pharmacology (W.C.S.), Yale University, New Haven, CT; Department of Pathology, NYU Langone Medical Center, New York, NY (C.F.-H.); and Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY (A.D.L.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/ATVBAHA.115.306861DOI Listing
March 2016

Interferon-γ-mediated allograft rejection exacerbates cardiovascular disease of hyperlipidemic murine transplant recipients.

Circ Res 2015 Nov 23;117(11):943-55. Epub 2015 Sep 23.

From the Departments of Surgery (J.Z., L.Q., R.A., Q.L., Y.J., G.L., J.J.Y., G.T.) and Immunobiology (T.Y., Z.T., J.S.P.) and Medicine (Y.H., J.Z., M.M.S., F.J.G.) and the Interdepartmental Program in Vascular Biology and Therapeutics (J.J.Y., M.M.S., F.J.G., J.S.P., G.T.), Yale University School of Medicine, New Haven, CT; Veterans Affairs Connecticut Healthcare System, West Haven (J.J.Y., M.M.S., F.J.G., G.T.); Research Institute, Nationwide Children's Hospital, Columbus, OH (T.Y.); and Department of Vascular Surgery, Peking University People's Hospital, Beijing, P.R. China (Q.L., Y.J.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCRESAHA.115.306932DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636943PMC
November 2015

Nogo-B regulates endothelial sphingolipid homeostasis to control vascular function and blood pressure.

Nat Med 2015 Sep 24;21(9):1028-1037. Epub 2015 Aug 24.

Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, Cornell University, New York, New York, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nm.3934DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4692717PMC
September 2015

Thioredoxin-2 inhibits mitochondrial reactive oxygen species generation and apoptosis stress kinase-1 activity to maintain cardiac function.

Circulation 2015 Mar 27;131(12):1082-97. Epub 2015 Jan 27.

From Interdepartmental Program in Vascular Biology and Therapeutics, Department of Pathology, University School of Medicine, New Haven, CT (Q.H., H.J.Z., H.Z., Y.H., F.J.G., W.M.); Center for Translational Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China (H.J.Z., W.M.); Gilead Sciences Inc, Foster City, CA (F.H.-K., P.F., L.Y., L.B., G.R.B.); and Department of Surgery, Yale University School of Medicine, New Haven, CT (G.T.).

View Article

Download full-text PDF

Source
https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.114.0
Publisher Site
http://dx.doi.org/10.1161/CIRCULATIONAHA.114.012725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374031PMC
March 2015

Activation of hypoxia-inducible factor-2 in adipocytes results in pathological cardiac hypertrophy.

J Am Heart Assoc 2013 Dec 10;2(6):e000548. Epub 2013 Dec 10.

Department of Therapeutic Radiology, Yale School of Medicine, New Haven, CT.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/JAHA.113.000548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3886757PMC
December 2013

Hypoxia-inducible factor-1α in vascular smooth muscle regulates blood pressure homeostasis through a peroxisome proliferator-activated receptor-γ-angiotensin II receptor type 1 axis.

Hypertension 2013 Sep 5;62(3):634-40. Epub 2013 Aug 5.

Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, 10 Amistad St, New Haven, CT 06520, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/HYPERTENSIONAHA.111.00160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354705PMC
September 2013

Rapamycin inhibits smooth muscle cell proliferation and obstructive arteriopathy attributable to elastin deficiency.

Arterioscler Thromb Vasc Biol 2013 May 14;33(5):1028-35. Epub 2013 Mar 14.

Department of Surgery, Interdepartmental Program in Vascular Biology and Therapeutics, Yale University School of Medicine, New Haven, CT, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/ATVBAHA.112.300407DOI Listing
May 2013

IL-13 receptor α2-arginase 2 pathway mediates IL-13-induced pulmonary hypertension.

Am J Physiol Lung Cell Mol Physiol 2013 Jan 2;304(2):L112-24. Epub 2012 Nov 2.

Yale University School of Medicine, Dept. of Internal Medicine, New Haven, CT 06520-8057, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajplung.00101.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3543640PMC
January 2013

Normal glucose uptake in the brain and heart requires an endothelial cell-specific HIF-1α-dependent function.

Proc Natl Acad Sci U S A 2012 Oct 9;109(43):17478-83. Epub 2012 Oct 9.

Department of Medicine, Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT 06510, USA.

View Article

Download full-text PDF

Source
http://www.pnas.org/cgi/doi/10.1073/pnas.1209281109
Publisher Site
http://dx.doi.org/10.1073/pnas.1209281109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491491PMC
October 2012

miR-1 mediated suppression of Sorcin regulates myocardial contractility through modulation of Ca2+ signaling.

J Mol Cell Cardiol 2012 May 4;52(5):1027-37. Epub 2012 Feb 4.

Section of Cardiac Surgery, Department of Surgery, Yale University, New Haven, CT 06510, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yjmcc.2012.01.020DOI Listing
May 2012

Inhibition of microRNA-29 enhances elastin levels in cells haploinsufficient for elastin and in bioengineered vessels--brief report.

Arterioscler Thromb Vasc Biol 2012 Mar 17;32(3):756-9. Epub 2011 Nov 17.

Department of Pharmacology, Yale University School of Medicine, Amistad Research Bldg, 10 Amistad St, New Haven, CT 06520, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/ATVBAHA.111.238113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288647PMC
March 2012

Inhibition of intimal hyperplasia after stenting by over-expression of p15: a member of the INK4 family of cyclin-dependent kinase inhibitors.

J Mol Cell Cardiol 2011 Mar 21;50(3):417-25. Epub 2010 Nov 21.

Interventional Cardiology Unit, Chaim Sheba Medical Center, Tel Hashomer, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yjmcc.2010.11.007DOI Listing
March 2011

Cell communications in the heart.

Circulation 2010 Aug;122(9):928-37

Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520-8017, USA.

View Article

Download full-text PDF

Source
https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.108.8
Publisher Site
http://dx.doi.org/10.1161/CIRCULATIONAHA.108.847731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2941440PMC
August 2010

VEGF receptor 2 endocytic trafficking regulates arterial morphogenesis.

Dev Cell 2010 May 6;18(5):713-24. Epub 2010 May 6.

Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.devcel.2010.02.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2875289PMC
May 2010

Oxygen: both a passenger and a biological determinant in the vasculature.

Authors:
Frank J Giordano

Arterioscler Thromb Vasc Biol 2010 Apr;30(4):641-2

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/ATVBAHA.110.202945DOI Listing
April 2010

Chapter 13. Oxygen as a direct and indirect biological determinant in the vasculature.

Methods Enzymol 2008 ;444:285-304

Cardiovascular Medicine, Department of Medicine, and Vascular Biology and Translation Program, Yale University School of Medicine, New Haven, Connecticut, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S0076-6879(08)02813-9DOI Listing
January 2009

Chromogranin B regulates calcium signaling, nuclear factor kappaB activity, and brain natriuretic peptide production in cardiomyocytes.

Circ Res 2008 May 17;102(10):1230-8. Epub 2008 Apr 17.

Department of Pharmacology, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06520-8066, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCRESAHA.107.166033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952358PMC
May 2008

Differentiation by association: is a cell's fate determined by the company it keeps?

Am J Physiol Heart Circ Physiol 2008 Apr 22;294(4):H1503-4. Epub 2008 Feb 22.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajpheart.00138.2008DOI Listing
April 2008

Urocortin2 inhibits tumor growth via effects on vascularization and cell proliferation.

Proc Natl Acad Sci U S A 2008 Mar 28;105(10):3939-44. Epub 2008 Feb 28.

Department of Medicine, Yale University, New Haven, CT 06520, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.0712366105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2268793PMC
March 2008

Reexpression of caveolin-1 in endothelium rescues the vascular, cardiac, and pulmonary defects in global caveolin-1 knockout mice.

J Exp Med 2007 Oct 24;204(10):2373-82. Epub 2007 Sep 24.

Department of Pharmacology and Program in Vascular Cell Signaling and Therapeutics, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT 06511.

View Article

Download full-text PDF

Source
http://jem.rupress.org/content/204/10/2373.full.pdf
Web Search
http://www.jem.org/lookup/doi/10.1084/jem.20062340
Publisher Site
http://dx.doi.org/10.1084/jem.20062340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118452PMC
October 2007

Endothelial-specific expression of mitochondrial thioredoxin improves endothelial cell function and reduces atherosclerotic lesions.

Am J Pathol 2007 Mar;170(3):1108-20

Interdepartmental Program in Vascular Biology and Transplantation, Department of Pathology, Yale University School of Medicine, BCMM 454, 295 Congress Ave., New Haven, CT 06510, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2353/ajpath.2007.060960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1864879PMC
March 2007

Therapeutic gene regulation: targeting transcription.

Authors:
Frank J Giordano

Circulation 2007 Mar;115(10):1180-3

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCULATIONAHA.106.685255DOI Listing
March 2007

An engineered VEGF-activating zinc finger protein transcription factor improves blood flow and limb salvage in advanced-age mice.

FASEB J 2006 Mar 19;20(3):479-81. Epub 2006 Jan 19.

Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1096/fj.04-3670fjeDOI Listing
March 2006

Smad2 and Smad3 play different roles in rat hepatic stellate cell function and alpha-smooth muscle actin organization.

Mol Biol Cell 2005 Sep 29;16(9):4214-24. Epub 2005 Jun 29.

The University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1091/mbc.e05-02-0149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1196331PMC
September 2005

Oxygen, oxidative stress, hypoxia, and heart failure.

Authors:
Frank J Giordano

J Clin Invest 2005 Mar;115(3):500-8

Department of Medicine, Yale University School of Medicine, New Haven, Connecticut 06510, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1172/JCI24408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1052012PMC
March 2005

Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis.

Cancer Cell 2004 Nov;6(5):485-95

Molecular Biology Section, Division of Biological Sciences, University of California, San Diego, San Diego, California 92093, USA.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S153561080400302
Publisher Site
http://dx.doi.org/10.1016/j.ccr.2004.09.026DOI Listing
November 2004

Loss of skeletal muscle HIF-1alpha results in altered exercise endurance.

PLoS Biol 2004 Oct 24;2(10):e288. Epub 2004 Aug 24.

Molecular Biology Section, Division of Biology, School of Medicine, University of California, San Diego, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pbio.0020288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC514537PMC
October 2004

AMP-activated protein kinase mediates ischemic glucose uptake and prevents postischemic cardiac dysfunction, apoptosis, and injury.

J Clin Invest 2004 Aug;114(4):495-503

Department of Internal Medicine (Section of Cardiovascular Medicine), Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1172/JCI19297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC503766PMC
August 2004

Stem cells and cardiovascular disease.

J Nucl Cardiol 2003 Jul-Aug;10(4):403-12

Division of Cardiovascular Medicine, Boyer Center for Molecular Medicine, Yale University School of Medicine, 295 Congress Avenue, New Haven, CT 06520, USA.

View Article

Download full-text PDF

Source
January 2004

Decorin inhibition of PDGF-stimulated vascular smooth muscle cell function: potential mechanism for inhibition of intimal hyperplasia after balloon angioplasty.

Am J Pathol 2003 Sep;163(3):869-78

Roy and Ann Foss Interventional Cardiology Research Program, Terrence Donnelly Heart Centre, St. Michael's Hospital, University of Toronto, 30 Bond Street, Toronto, Ontario, Canada M5B 1W8.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1868258PMC
http://dx.doi.org/10.1016/S0002-9440(10)63447-5DOI Listing
September 2003

Retrograde coronary perfusion: a superior route to deliver therapeutics to the heart?*.

Authors:
Frank J Giordano

J Am Coll Cardiol 2003 Sep;42(6):1129-31

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0735-1097(03)00903-3DOI Listing
September 2003

Gene-based therapeutic angiogenesis.

Semin Thorac Cardiovasc Surg 2003 Jul;15(3):236-49

Department of Medicine, Cardiovascular Gene Therapy Program, Yale University School of Medicine, New Haven, CT, USA.

View Article

Download full-text PDF

Source
July 2003

Cell-permeable peptides improve cellular uptake and therapeutic gene delivery of replication-deficient viruses in cells and in vivo.

Nat Med 2003 Mar 24;9(3):357-62. Epub 2003 Feb 24.

Department of Pharmacology, Vascular Cell Signaling and Therapeutics Program, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nm835DOI Listing
March 2003

A new role for corticotropin-releasing factor receptor-2: suppression of vascularization.

Trends Cardiovasc Med 2003 Feb;13(2):68-71

Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, 10010 N. Torrey Pines Road, La Jolla, CA 92037, USA.

View Article

Download full-text PDF

Source
February 2003

Corticotropin-releasing factor receptor 2 is a tonic suppressor of vascularization.

Proc Natl Acad Sci U S A 2002 May;99(11):7734-9

Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, La Jolla, CA 92037, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.102187099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC124337PMC
May 2002

Restoration of deficient membrane proteins in the cardiomyopathic hamster by in vivo cardiac gene transfer.

Circulation 2002 Jan;105(4):502-8

Department of Medicine, Division of Cardiology, University of California, San Diego, CA 92093-0613B, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/hc0402.102953DOI Listing
January 2002