Frank Claessens

Frank Claessens

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Frank Claessens

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AR variants: lost in translation to clinical practice?

Nat Rev Urol 2019 Jun 10. Epub 2019 Jun 10.

Molecular Endocrinology Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1038/s41585-019-0204-4DOI Listing
June 2019

Androgen Receptor in Neurons Slows Age-Related Cortical Thinning in Male Mice.

J Bone Miner Res 2019 Mar 15;34(3):508-519. Epub 2019 Jan 15.

Clinical and Experimental Endocrinology, Department of Chronic Diseases, Metabolism and Aging (CHROMETA), KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1002/jbmr.3625DOI Listing
March 2019

Author Correction: Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci.

Authors:
Fredrick R Schumacher Ali Amin Al Olama Sonja I Berndt Sara Benlloch Mahbubl Ahmed Edward J Saunders Tokhir Dadaev Daniel Leongamornlert Ezequiel Anokian Clara Cieza-Borrella Chee Goh Mark N Brook Xin Sheng Laura Fachal Joe Dennis Jonathan Tyrer Kenneth Muir Artitaya Lophatananon Victoria L Stevens Susan M Gapstur Brian D Carter Catherine M Tangen Phyllis J Goodman Ian M Thompson Jyotsna Batra Suzanne Chambers Leire Moya Judith Clements Lisa Horvath Wayne Tilley Gail P Risbridger Henrik Gronberg Markus Aly Tobias Nordström Paul Pharoah Nora Pashayan Johanna Schleutker Teuvo L J Tammela Csilla Sipeky Anssi Auvinen Demetrius Albanes Stephanie Weinstein Alicja Wolk Niclas Håkansson Catharine M L West Alison M Dunning Neil Burnet Lorelei A Mucci Edward Giovannucci Gerald L Andriole Olivier Cussenot Géraldine Cancel-Tassin Stella Koutros Laura E Beane Freeman Karina Dalsgaard Sorensen Torben Falck Orntoft Michael Borre Lovise Maehle Eli Marie Grindedal David E Neal Jenny L Donovan Freddie C Hamdy Richard M Martin Ruth C Travis Tim J Key Robert J Hamilton Neil E Fleshner Antonio Finelli Sue Ann Ingles Mariana C Stern Barry S Rosenstein Sarah L Kerns Harry Ostrer Yong-Jie Lu Hong-Wei Zhang Ninghan Feng Xueying Mao Xin Guo Guomin Wang Zan Sun Graham G Giles Melissa C Southey Robert J MacInnis Liesel M FitzGerald Adam S Kibel Bettina F Drake Ana Vega Antonio Gómez-Caamaño Robert Szulkin Martin Eklund Manolis Kogevinas Javier Llorca Gemma Castaño-Vinyals Kathryn L Penney Meir Stampfer Jong Y Park Thomas A Sellers Hui-Yi Lin Janet L Stanford Cezary Cybulski Dominika Wokolorczyk Jan Lubinski Elaine A Ostrander Milan S Geybels Børge G Nordestgaard Sune F Nielsen Maren Weischer Rasmus Bisbjerg Martin Andreas Røder Peter Iversen Hermann Brenner Katarina Cuk Bernd Holleczek Christiane Maier Manuel Luedeke Thomas Schnoeller Jeri Kim Christopher J Logothetis Esther M John Manuel R Teixeira Paula Paulo Marta Cardoso Susan L Neuhausen Linda Steele Yuan Chun Ding Kim De Ruyck Gert De Meerleer Piet Ost Azad Razack Jasmine Lim Soo-Hwang Teo Daniel W Lin Lisa F Newcomb Davor Lessel Marija Gamulin Tomislav Kulis Radka Kaneva Nawaid Usmani Sandeep Singhal Chavdar Slavov Vanio Mitev Matthew Parliament Frank Claessens Steven Joniau Thomas Van den Broeck Samantha Larkin Paul A Townsend Claire Aukim-Hastie Manuela Gago-Dominguez Jose Esteban Castelao Maria Elena Martinez Monique J Roobol Guido Jenster Ron H N van Schaik Florence Menegaux Thérèse Truong Yves Akoli Koudou Jianfeng Xu Kay-Tee Khaw Lisa Cannon-Albright Hardev Pandha Agnieszka Michael Stephen N Thibodeau Shannon K McDonnell Daniel J Schaid Sara Lindstrom Constance Turman Jing Ma David J Hunter Elio Riboli Afshan Siddiq Federico Canzian Laurence N Kolonel Loic Le Marchand Robert N Hoover Mitchell J Machiela Zuxi Cui Peter Kraft Christopher I Amos David V Conti Douglas F Easton Fredrik Wiklund Stephen J Chanock Brian E Henderson Zsofia Kote-Jarai Christopher A Haiman Rosalind A Eeles

Nat Genet 2019 02;51(2):363

Institute of Cancer Research, London, UK.

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http://www.nature.com/articles/s41588-018-0330-6
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http://dx.doi.org/10.1038/s41588-018-0330-6DOI Listing
February 2019

Circulating Metabolic Biomarkers of Screen-Detected Prostate Cancer in the ProtecT Study.

Cancer Epidemiol Biomarkers Prev 2019 Jan 23;28(1):208-216. Epub 2018 Oct 23.

MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, United Kingdom.

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http://cebp.aacrjournals.org/lookup/doi/10.1158/1055-9965.EP
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http://dx.doi.org/10.1158/1055-9965.EPI-18-0079DOI Listing
January 2019

Author Correction: Germline variation at 8q24 and prostate cancer risk in men of European ancestry.

Nat Commun 2019 01 17;10(1):382. Epub 2019 Jan 17.

Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, 90033, USA.

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http://dx.doi.org/10.1038/s41467-019-08293-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336778PMC
January 2019

Shared heritability and functional enrichment across six solid cancers.

Authors:
Xia Jiang Hilary K Finucane Fredrick R Schumacher Stephanie L Schmit Jonathan P Tyrer Younghun Han Kyriaki Michailidou Corina Lesseur Karoline B Kuchenbaecker Joe Dennis David V Conti Graham Casey Mia M Gaudet Jeroen R Huyghe Demetrius Albanes Melinda C Aldrich Angeline S Andrew Irene L Andrulis Hoda Anton-Culver Antonis C Antoniou Natalia N Antonenkova Susanne M Arnold Kristan J Aronson Banu K Arun Elisa V Bandera Rosa B Barkardottir Daniel R Barnes Jyotsna Batra Matthias W Beckmann Javier Benitez Sara Benlloch Andrew Berchuck Sonja I Berndt Heike Bickeböller Stephanie A Bien Carl Blomqvist Stefania Boccia Natalia V Bogdanova Stig E Bojesen Manjeet K Bolla Hiltrud Brauch Hermann Brenner James D Brenton Mark N Brook Joan Brunet Hans Brunnström Daniel D Buchanan Barbara Burwinkel Ralf Butzow Gabriella Cadoni Trinidad Caldés Maria A Caligo Ian Campbell Peter T Campbell Géraldine Cancel-Tassin Lisa Cannon-Albright Daniele Campa Neil Caporaso André L Carvalho Andrew T Chan Jenny Chang-Claude Stephen J Chanock Chu Chen David C Christiani Kathleen B M Claes Frank Claessens Judith Clements J Margriet Collée Marcia Cruz Correa Fergus J Couch Angela Cox Julie M Cunningham Cezary Cybulski Kamila Czene Mary B Daly Anna deFazio Peter Devilee Orland Diez Manuela Gago-Dominguez Jenny L Donovan Thilo Dörk Eric J Duell Alison M Dunning Miriam Dwek Diana M Eccles Christopher K Edlund Digna R Velez Edwards Carolina Ellberg D Gareth Evans Peter A Fasching Robert L Ferris Triantafillos Liloglou Jane C Figueiredo Olivia Fletcher Renée T Fortner Florentia Fostira Silvia Franceschi Eitan Friedman Steven J Gallinger Patricia A Ganz Judy Garber José A García-Sáenz Simon A Gayther Graham G Giles Andrew K Godwin Mark S Goldberg David E Goldgar Ellen L Goode Marc T Goodman Gary Goodman Kjell Grankvist Mark H Greene Henrik Gronberg Jacek Gronwald Pascal Guénel Niclas Håkansson Per Hall Ute Hamann Freddie C Hamdy Robert J Hamilton Jochen Hampe Aage Haugen Florian Heitz Rolando Herrero Peter Hillemanns Michael Hoffmeister Estrid Høgdall Yun-Chul Hong John L Hopper Richard Houlston Peter J Hulick David J Hunter David G Huntsman Gregory Idos Evgeny N Imyanitov Sue Ann Ingles Claudine Isaacs Anna Jakubowska Paul James Mark A Jenkins Mattias Johansson Mikael Johansson Esther M John Amit D Joshi Radka Kaneva Beth Y Karlan Linda E Kelemen Tabea Kühl Kay-Tee Khaw Elza Khusnutdinova Adam S Kibel Lambertus A Kiemeney Jeri Kim Susanne K Kjaer Julia A Knight Manolis Kogevinas Zsofia Kote-Jarai Stella Koutros Vessela N Kristensen Jolanta Kupryjanczyk Martin Lacko Stephan Lam Diether Lambrechts Maria Teresa Landi Philip Lazarus Nhu D Le Eunjung Lee Flavio Lejbkowicz Heinz-Josef Lenz Goska Leslie Davor Lessel Jenny Lester Douglas A Levine Li Li Christopher I Li Annika Lindblom Noralane M Lindor Geoffrey Liu Fotios Loupakis Jan Lubiński Lovise Maehle Christiane Maier Arto Mannermaa Loic Le Marchand Sara Margolin Taymaa May Lesley McGuffog Alfons Meindl Pooja Middha Austin Miller Roger L Milne Robert J MacInnis Francesmary Modugno Marco Montagna Victor Moreno Kirsten B Moysich Lorelei Mucci Kenneth Muir Anna Marie Mulligan Katherine L Nathanson David E Neal Andrew R Ness Susan L Neuhausen Heli Nevanlinna Polly A Newcomb Lisa F Newcomb Finn Cilius Nielsen Liene Nikitina-Zake Børge G Nordestgaard Robert L Nussbaum Kenneth Offit Edith Olah Ali Amin Al Olama Olufunmilayo I Olopade Andrew F Olshan Håkan Olsson Ana Osorio Hardev Pandha Jong Y Park Nora Pashayan Michael T Parsons Tanja Pejovic Kathryn L Penney Wilbert H M Peters Catherine M Phelan Amanda I Phipps Dijana Plaseska-Karanfilska Miranda Pring Darya Prokofyeva Paolo Radice Kari Stefansson Susan J Ramus Leon Raskin Gad Rennert Hedy S Rennert Elizabeth J van Rensburg Marjorie J Riggan Harvey A Risch Angela Risch Monique J Roobol Barry S Rosenstein Mary Anne Rossing Kim De Ruyck Emmanouil Saloustros Dale P Sandler Elinor J Sawyer Matthew B Schabath Johanna Schleutker Marjanka K Schmidt V Wendy Setiawan Hongbing Shen Erin M Siegel Weiva Sieh Christian F Singer Martha L Slattery Karina Dalsgaard Sorensen Melissa C Southey Amanda B Spurdle Janet L Stanford Victoria L Stevens Sebastian Stintzing Jennifer Stone Karin Sundfeldt Rebecca Sutphen Anthony J Swerdlow Eloiza H Tajara Catherine M Tangen Adonina Tardon Jack A Taylor M Dawn Teare Manuel R Teixeira Mary Beth Terry Kathryn L Terry Stephen N Thibodeau Mads Thomassen Line Bjørge Marc Tischkowitz Amanda E Toland Diana Torres Paul A Townsend Ruth C Travis Nadine Tung Shelley S Tworoger Cornelia M Ulrich Nawaid Usmani Celine M Vachon Els Van Nieuwenhuysen Ana Vega Miguel Elías Aguado-Barrera Qin Wang Penelope M Webb Clarice R Weinberg Stephanie Weinstein Mark C Weissler Jeffrey N Weitzel Catharine M L West Emily White Alice S Whittemore H-Erich Wichmann Fredrik Wiklund Robert Winqvist Alicja Wolk Penella Woll Michael Woods Anna H Wu Xifeng Wu Drakoulis Yannoukakos Wei Zheng Shanbeh Zienolddiny Argyrios Ziogas Kristin K Zorn Jacqueline M Lane Richa Saxena Duncan Thomas Rayjean J Hung Brenda Diergaarde James McKay Ulrike Peters Li Hsu Montserrat García-Closas Rosalind A Eeles Georgia Chenevix-Trench Paul J Brennan Christopher A Haiman Jacques Simard Douglas F Easton Stephen B Gruber Paul D P Pharoah Alkes L Price Bogdan Pasaniuc Christopher I Amos Peter Kraft Sara Lindström

Nat Commun 2019 01 25;10(1):431. Epub 2019 Jan 25.

Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., Seattle, WA, 98109-1024, USA.

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http://dx.doi.org/10.1038/s41467-018-08054-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347624PMC
January 2019

Inhibition of androgen receptor transactivation function by adenovirus type 12 E1A undermines prostate cancer cell survival.

Prostate 2018 11 15;78(15):1140-1156. Epub 2018 Jul 15.

Department of Anatomy and Cell Biology, UF Health Cancer Center and UF Genetics Institute, University of Florida College of Medicine, Gainesville, Florida.

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http://dx.doi.org/10.1002/pros.23689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424568PMC
November 2018

Synthesis, biological evaluation and molecular modeling of a novel series of fused 1,2,3-triazoles as potential anti-coronavirus agents.

Bioorg Med Chem Lett 2018 11 22;28(21):3472-3476. Epub 2018 Sep 22.

Molecular Design and Synthesis, Department of Chemistry, KU Leuven, Celestijnenlaan 200F, 3001 Leuven, Belgium. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0960894X183075
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http://dx.doi.org/10.1016/j.bmcl.2018.09.019DOI Listing
November 2018

Germline variation at 8q24 and prostate cancer risk in men of European ancestry.

Nat Commun 2018 11 5;9(1):4616. Epub 2018 Nov 5.

Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, 90033, USA.

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http://www.nature.com/articles/s41467-018-06863-1
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http://dx.doi.org/10.1038/s41467-018-06863-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218483PMC
November 2018

Genito-urinary genomics and emerging biomarkers for immunomodulatory cancer treatment.

Semin Cancer Biol 2018 10 12;52(Pt 2):216-227. Epub 2017 Oct 12.

Department of Pathology, University Clinics St Luc, Sint-Lambrechts-Woluwe, Belgium.

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http://dx.doi.org/10.1016/j.semcancer.2017.10.004DOI Listing
October 2018

A kindred with mutant IKAROS and autoimmunity.

J Allergy Clin Immunol 2018 Aug 27;142(2):699-702.e12. Epub 2018 Apr 27.

Department of Microbiology and Immunology, KUL - University of Leuven, Leuven, Belgium; VIB Center for Brain and Disease Research, Leuven, Belgium. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00916749183061
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http://dx.doi.org/10.1016/j.jaci.2018.04.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541477PMC
August 2018

Androgen and estrogen actions on male physical activity: a story beyond muscle.

J Endocrinol 2018 Jul 9;238(1):R31-R52. Epub 2018 May 9.

Molecular Endocrinology LaboratoryDepartment of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1530/JOE-18-0125DOI Listing
July 2018

Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci.

Authors:
Fredrick R Schumacher Ali Amin Al Olama Sonja I Berndt Sara Benlloch Mahbubl Ahmed Edward J Saunders Tokhir Dadaev Daniel Leongamornlert Ezequiel Anokian Clara Cieza-Borrella Chee Goh Mark N Brook Xin Sheng Laura Fachal Joe Dennis Jonathan Tyrer Kenneth Muir Artitaya Lophatananon Victoria L Stevens Susan M Gapstur Brian D Carter Catherine M Tangen Phyllis J Goodman Ian M Thompson Jyotsna Batra Suzanne Chambers Leire Moya Judith Clements Lisa Horvath Wayne Tilley Gail P Risbridger Henrik Gronberg Markus Aly Tobias Nordström Paul Pharoah Nora Pashayan Johanna Schleutker Teuvo L J Tammela Csilla Sipeky Anssi Auvinen Demetrius Albanes Stephanie Weinstein Alicja Wolk Niclas Håkansson Catharine M L West Alison M Dunning Neil Burnet Lorelei A Mucci Edward Giovannucci Gerald L Andriole Olivier Cussenot Géraldine Cancel-Tassin Stella Koutros Laura E Beane Freeman Karina Dalsgaard Sorensen Torben Falck Orntoft Michael Borre Lovise Maehle Eli Marie Grindedal David E Neal Jenny L Donovan Freddie C Hamdy Richard M Martin Ruth C Travis Tim J Key Robert J Hamilton Neil E Fleshner Antonio Finelli Sue Ann Ingles Mariana C Stern Barry S Rosenstein Sarah L Kerns Harry Ostrer Yong-Jie Lu Hong-Wei Zhang Ninghan Feng Xueying Mao Xin Guo Guomin Wang Zan Sun Graham G Giles Melissa C Southey Robert J MacInnis Liesel M FitzGerald Adam S Kibel Bettina F Drake Ana Vega Antonio Gómez-Caamaño Robert Szulkin Martin Eklund Manolis Kogevinas Javier Llorca Gemma Castaño-Vinyals Kathryn L Penney Meir Stampfer Jong Y Park Thomas A Sellers Hui-Yi Lin Janet L Stanford Cezary Cybulski Dominika Wokolorczyk Jan Lubinski Elaine A Ostrander Milan S Geybels Børge G Nordestgaard Sune F Nielsen Maren Weischer Rasmus Bisbjerg Martin Andreas Røder Peter Iversen Hermann Brenner Katarina Cuk Bernd Holleczek Christiane Maier Manuel Luedeke Thomas Schnoeller Jeri Kim Christopher J Logothetis Esther M John Manuel R Teixeira Paula Paulo Marta Cardoso Susan L Neuhausen Linda Steele Yuan Chun Ding Kim De Ruyck Gert De Meerleer Piet Ost Azad Razack Jasmine Lim Soo-Hwang Teo Daniel W Lin Lisa F Newcomb Davor Lessel Marija Gamulin Tomislav Kulis Radka Kaneva Nawaid Usmani Sandeep Singhal Chavdar Slavov Vanio Mitev Matthew Parliament Frank Claessens Steven Joniau Thomas Van den Broeck Samantha Larkin Paul A Townsend Claire Aukim-Hastie Manuela Gago-Dominguez Jose Esteban Castelao Maria Elena Martinez Monique J Roobol Guido Jenster Ron H N van Schaik Florence Menegaux Thérèse Truong Yves Akoli Koudou Jianfeng Xu Kay-Tee Khaw Lisa Cannon-Albright Hardev Pandha Agnieszka Michael Stephen N Thibodeau Shannon K McDonnell Daniel J Schaid Sara Lindstrom Constance Turman Jing Ma David J Hunter Elio Riboli Afshan Siddiq Federico Canzian Laurence N Kolonel Loic Le Marchand Robert N Hoover Mitchell J Machiela Zuxi Cui Peter Kraft Christopher I Amos David V Conti Douglas F Easton Fredrik Wiklund Stephen J Chanock Brian E Henderson Zsofia Kote-Jarai Christopher A Haiman Rosalind A Eeles

Nat Genet 2018 07 11;50(7):928-936. Epub 2018 Jun 11.

Institute of Cancer Research, London, UK.

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http://dx.doi.org/10.1038/s41588-018-0142-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6568012PMC
July 2018

Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants.

Authors:
Tokhir Dadaev Edward J Saunders Paul J Newcombe Ezequiel Anokian Daniel A Leongamornlert Mark N Brook Clara Cieza-Borrella Martina Mijuskovic Sarah Wakerell Ali Amin Al Olama Fredrick R Schumacher Sonja I Berndt Sara Benlloch Mahbubl Ahmed Chee Goh Xin Sheng Zhuo Zhang Kenneth Muir Koveela Govindasami Artitaya Lophatananon Victoria L Stevens Susan M Gapstur Brian D Carter Catherine M Tangen Phyllis Goodman Ian M Thompson Jyotsna Batra Suzanne Chambers Leire Moya Judith Clements Lisa Horvath Wayne Tilley Gail Risbridger Henrik Gronberg Markus Aly Tobias Nordström Paul Pharoah Nora Pashayan Johanna Schleutker Teuvo L J Tammela Csilla Sipeky Anssi Auvinen Demetrius Albanes Stephanie Weinstein Alicja Wolk Niclas Hakansson Catharine West Alison M Dunning Neil Burnet Lorelei Mucci Edward Giovannucci Gerald Andriole Olivier Cussenot Géraldine Cancel-Tassin Stella Koutros Laura E Beane Freeman Karina Dalsgaard Sorensen Torben Falck Orntoft Michael Borre Lovise Maehle Eli Marie Grindedal David E Neal Jenny L Donovan Freddie C Hamdy Richard M Martin Ruth C Travis Tim J Key Robert J Hamilton Neil E Fleshner Antonio Finelli Sue Ann Ingles Mariana C Stern Barry Rosenstein Sarah Kerns Harry Ostrer Yong-Jie Lu Hong-Wei Zhang Ninghan Feng Xueying Mao Xin Guo Guomin Wang Zan Sun Graham G Giles Melissa C Southey Robert J MacInnis Liesel M FitzGerald Adam S Kibel Bettina F Drake Ana Vega Antonio Gómez-Caamaño Laura Fachal Robert Szulkin Martin Eklund Manolis Kogevinas Javier Llorca Gemma Castaño-Vinyals Kathryn L Penney Meir Stampfer Jong Y Park Thomas A Sellers Hui-Yi Lin Janet L Stanford Cezary Cybulski Dominika Wokolorczyk Jan Lubinski Elaine A Ostrander Milan S Geybels Børge G Nordestgaard Sune F Nielsen Maren Weisher Rasmus Bisbjerg Martin Andreas Røder Peter Iversen Hermann Brenner Katarina Cuk Bernd Holleczek Christiane Maier Manuel Luedeke Thomas Schnoeller Jeri Kim Christopher J Logothetis Esther M John Manuel R Teixeira Paula Paulo Marta Cardoso Susan L Neuhausen Linda Steele Yuan Chun Ding Kim De Ruyck Gert De Meerleer Piet Ost Azad Razack Jasmine Lim Soo-Hwang Teo Daniel W Lin Lisa F Newcomb Davor Lessel Marija Gamulin Tomislav Kulis Radka Kaneva Nawaid Usmani Chavdar Slavov Vanio Mitev Matthew Parliament Sandeep Singhal Frank Claessens Steven Joniau Thomas Van den Broeck Samantha Larkin Paul A Townsend Claire Aukim-Hastie Manuela Gago-Dominguez Jose Esteban Castelao Maria Elena Martinez Monique J Roobol Guido Jenster Ron H N van Schaik Florence Menegaux Thérèse Truong Yves Akoli Koudou Jianfeng Xu Kay-Tee Khaw Lisa Cannon-Albright Hardev Pandha Agnieszka Michael Andrzej Kierzek Stephen N Thibodeau Shannon K McDonnell Daniel J Schaid Sara Lindstrom Constance Turman Jing Ma David J Hunter Elio Riboli Afshan Siddiq Federico Canzian Laurence N Kolonel Loic Le Marchand Robert N Hoover Mitchell J Machiela Peter Kraft Matthew Freedman Fredrik Wiklund Stephen Chanock Brian E Henderson Douglas F Easton Christopher A Haiman Rosalind A Eeles David V Conti Zsofia Kote-Jarai

Nat Commun 2018 06 11;9(1):2256. Epub 2018 Jun 11.

The Institute of Cancer Research, London, SW7 3RP, UK.

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http://dx.doi.org/10.1038/s41467-018-04109-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995836PMC
June 2018

Sex steroids and the kidney: role in renal calcium and phosphate handling.

Mol Cell Endocrinol 2018 04 16;465:61-72. Epub 2017 Nov 16.

Clinical and Experimental Endocrinology, KU Leuven, Herestraat 49 Box 902, Belgium.

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http://dx.doi.org/10.1016/j.mce.2017.11.011DOI Listing
April 2018

Endocrinology of prostate cancer.

Mol Cell Endocrinol 2018 02;462(Pt A):1-2

Prostate Cancer Research Center, Institute for Biomedical Technology, FI-33014 University of Tampere, Biokatu, 6-8 33520, Tampere, Finland.

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http://dx.doi.org/10.1016/j.mce.2018.01.005DOI Listing
February 2018

Estradiol and Age-Related Bone Loss in Men.

Physiol Rev 2018 01;98(1)

Department of Clinical and Experimental Medicine, Clinical and Experimental Endocrinology, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1152/physrev.00051.2017DOI Listing
January 2018

Prostate cancer: The influence of steroid metabolism on CYP17A1 inhibitor activity.

Nat Rev Urol 2017 Oct 8;14(10):590-592. Epub 2017 Aug 8.

Molecular Endocrinology Laboratory, Department of Cellular and Molecular Medicine, Campus Gasthuisberg, Herestraat 49, PO Box 901, 3000 Leuven, Belgium; and at the Department of Urology, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium.

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http://www.nature.com/doifinder/10.1038/nrurol.2017.132
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http://dx.doi.org/10.1038/nrurol.2017.132DOI Listing
October 2017

A shortened tamoxifen induction scheme to induce CreER recombinase without side effects on the male mouse skeleton.

Mol Cell Endocrinol 2017 09 11;452:57-63. Epub 2017 May 11.

Clinical and Experimental Endocrinology, Department of Cellular and Molecular Medicine, KU Leuven, Herestraat 49 PO Box 902, 3000 Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.mce.2017.05.012DOI Listing
September 2017

Comparing the rules of engagement of androgen and glucocorticoid receptors.

Cell Mol Life Sci 2017 06 6;74(12):2217-2228. Epub 2017 Feb 6.

Molecular Endocrinology Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, Campus GHB ON1, Herestraat 49, PO Box 901, 3000, Leuven, Belgium.

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http://dx.doi.org/10.1007/s00018-017-2467-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425506PMC
June 2017

Structure of the homodimeric androgen receptor ligand-binding domain.

Nat Commun 2017 02 6;8:14388. Epub 2017 Feb 6.

Department of Biochemistry and Molecular Biomedicine, Institute of Biomedicine (IBUB) of the University of Barcelona (UB), Barcelona 08028, Spain.

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http://dx.doi.org/10.1038/ncomms14388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5303882PMC
February 2017

Estrogens and Androgens in Skeletal Physiology and Pathophysiology.

Physiol Rev 2017 01;97(1):135-187

Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences and the Central Arkansas Veterans Healthcare System, Little Rock, Arkansas; Departments of Cellular and Molecular Medicine and Clinical and Experimental Medicine, KU Leuven, Leuven, Belgium; Center for Metabolic Bone Diseases, University Hospitals Leuven, Leuven, Belgium; and Institut National de la Santé et de la Recherche Médicale UMR1011, University of Lille and Institut Pasteur de Lille, Lille, France.

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http://dx.doi.org/10.1152/physrev.00033.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5539371PMC
January 2017

Effects of sex hormone-binding globulin (SHBG) on androgen bioactivity in vitro.

Mol Cell Endocrinol 2016 12 26;437:280-291. Epub 2016 Aug 26.

Laboratory of Molecular Endocrinology, Department of Cellular and Molecular Medicine, KU Leuven, Herestraat 49 PO Box 901, 3000, Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.mce.2016.08.041DOI Listing
December 2016

Androgens have antiresorptive effects on trabecular disuse osteopenia independent from muscle atrophy.

Bone 2016 12 10;93:33-42. Epub 2016 Sep 10.

Clinical and Experimental Endocrinology, Department of Cellular and Molecular Medicine, KU Leuven, Herestraat 49, PO box 902, 3000 Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.bone.2016.09.011DOI Listing
December 2016

Muscle-bone interactions: From experimental models to the clinic? A critical update.

Mol Cell Endocrinol 2016 09 23;432:14-36. Epub 2015 Oct 23.

Clinical and Experimental Endocrinology, Department of Clinical and Experimental Medicine, KU Leuven, 3000 Leuven, Belgium.

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http://dx.doi.org/10.1016/j.mce.2015.10.017DOI Listing
September 2016

Low Free Testosterone Is Associated with Hypogonadal Signs and Symptoms in Men with Normal Total Testosterone.

J Clin Endocrinol Metab 2016 07 24;101(7):2647-57. Epub 2016 Feb 24.

Department of Clinical and Experimental Medicine (L.A., B.D., D.V.), KU Leuven, Laboratory of Clinical and Experimental Endocrinology, Leuven, Belgium; Department of Cellular and Molecular Medicine (L.A., M.R.L., F.C.), KU Leuven, Laboratory of Molecular Endocrinology, Leuven, Belgium; Department of Endocrinology (L.A., B.D., D.V.), University Hospitals Leuven, Leuven, Belgium; Andrology Research Unit (F.C.W.W., T.B.A.), Endocrinology and Diabetes Research Group, Institute of Human Development, Faculty of Medical and Human Sciences, The University of Manchester, Manchester, UK; Manchester Royal Infirmary (F.C.W.W.), Central Manchester University Hospitals National Health Services (NHS) Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK; Arthritis Research UK Centre of Epidemiology (T.W.O.N., S.R.P.), The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK; National Institute for Health Research Manchester Musculoskeletal Biomedical Research Unit (T.W.O.N.), Central Manchester NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK; Department of Clinical and Experimental Medicine (M.R.L.), KU Leuven, Laboratory of Gerontology and Geriatrics, Leuven, Belgium; Department of Surgery and Cancer, Imperial College London (I.T.H.), Hammersmith Campus, London, UK; Department of Physiology (I.T.H.), Institute of Biomedicine, University of Turku, Turku, Finland; Department of Human Nutrition (M.E.J.L.), University of Glasgow, Glasgow, UK; Department of Clinical Biochemistry (B.G.K.), University Hospital of South Manchester, Manchester, UK; Sexual Medicine and Andrology Unit (G.R.), Department of Experimental Clinical and Biochemical Sciences, University of Florence, Florence, Italy; Endocrinology Unit (G.F.), Department of Experimental Clinical and Biochemical Sciences, University of Florence, Florence, Italy; Department of Obstetrics, Gynaecology and Andrology (G.B.), Albert Szent-György Medica

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http://dx.doi.org/10.1210/jc.2015-4106DOI Listing
July 2016

The Effect of F877L and T878A Mutations on Androgen Receptor Response to Enzalutamide.

Mol Cancer Ther 2016 07 16;15(7):1702-12. Epub 2016 May 16.

Molecular Endocrinology Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1158/1535-7163.MCT-15-0892DOI Listing
July 2016

Androgen Deficiency Exacerbates High-Fat Diet-Induced Metabolic Alterations in Male Mice.

Endocrinology 2016 Feb 12;157(2):648-65. Epub 2015 Nov 12.

Molecular Endocrinology Laboratory (V.D., M.R.L., L.A., F.C.), Department of Cellular and Molecular Medicine, KU Leuven, 3000 Leuven, Belgium; Gerontology and Geriatrics (M.R.L.), KU Leuven, 3000 Leuven, Belgium; Clinical and Experimental Endocrinology (F.J., L.A., G.C., B.D., D.V.), Department of Clinical and Experimental Medicine, KU Leuven, 3000 Leuven, Belgium; Gene Expression Unit (K.L., L.G.), Department of Cellular and Molecular Medicine, KU Leuven, 3000 Leuven, Belgium; Exercise Physiology Research Group (L.D.), Department of Kinesiology, KU Leuven, 3000 Leuven, Belgium; and Institute of Neuroscience (L.D.), Université Catholique de Louvain, 1348 Louvain-la-Neuve, Belgium.

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http://dx.doi.org/10.1210/en.2015-1713DOI Listing
February 2016

Enobosarm (GTx-024) Modulates Adult Skeletal Muscle Mass Independently of the Androgen Receptor in the Satellite Cell Lineage.

Endocrinology 2015 Dec 22;156(12):4522-33. Epub 2015 Sep 22.

Molecular Endocrinology Laboratory (V.D., M.R.L., F.C.), Department of Cellular and Molecular Medicine, Department of Gerontology and Geriatrics (M.R.L.), and Clinical and Experimental Endocrinology (F.J., D.V.), Department of Clinical and Experimental Medicine, KU Leuven, 3000 Leuven, Belgium; and Medical Research Council Centre for Inflammation Research (I.S., P.T.K.S.), University of Edinburgh, Edinburgh EH16 4SB, United Kingdom.

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http://dx.doi.org/10.1210/en.2015-1479DOI Listing
December 2015

Endocrine determinants of incident sarcopenia in middle-aged and elderly European men.

J Cachexia Sarcopenia Muscle 2015 Sep 27;6(3):242-52. Epub 2015 Apr 27.

Research Group for Musculoskeletal Rehabilitation, Department of Rehabilitation Sciences, KU Leuven Leuven, Belgium.

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http://dx.doi.org/10.1002/jcsm.12030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4575556PMC
September 2015

The androgen receptor has no direct antiresorptive actions in mouse osteoclasts.

Mol Cell Endocrinol 2015 Aug 6;411:198-206. Epub 2015 May 6.

Clinical and Experimental Endocrinology, Department of Clinical and Experimental Medicine, KU Leuven, Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.mce.2015.04.030DOI Listing
August 2015

Associations between sex steroids and the development of metabolic syndrome: a longitudinal study in European men.

J Clin Endocrinol Metab 2015 Apr 30;100(4):1396-404. Epub 2015 Jan 30.

Department of Clinical and Experimental Medicine (L.A., B.D., D.V.), KU Leuven, Laboratory of Clinical and Experimental Endocrinology, B-3000 Leuven, Belgium; Department of Cellular and Molecular Medicine (L.A., M.R.L., F.C.), KU Leuven, Laboratory of Molecular Endocrinology, B-3000 Leuven, Belgium; Department of Endocrinology (L.A., B.D., D.V.), University Hospitals Leuven, B-3000 Leuven, Belgium; Andrology Research Unit (F.C.W.W., E.L.C., J.D.F., M.K.R.), Endocrinology and Diabetes Research Group, Institute of Human Development, Faculty of Medical and Human Sciences, The University of Manchester, Manchester M13 9WL, United Kingdom; Manchester Royal Infirmary (F.C.W.W.), Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester M13 9WL, United Kingdom; Arthritis Research UK Centre of Epidemiology (T.W.O., S.R.P.), The University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9WL, United Kingdom; NIHR Manchester Musculoskeletal Biomedical Research Unit (T.W.O.), Central Manchester NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester M13 9WL, United Kingdom; The Endocrinology and Diabetes Research Group (M.K.R.), Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9WL United Kingdom; Manchester Diabetes Centre (M.K.R.), Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester M13 9WL, United Kingdom; Department of Clinical and Experimental Medicine (M.R.L.), KU Leuven, Laboratory of Gerontology and Geriatrics, B-3000 Leuven, Belgium; Department of Surgery and Cancer (I.T.H.), Imperial College London, Hammersmith Campus, London W12 ONN, United Kingdom; Department of Endocrinology (T.S.H.), Ashford and St. Peter's NHS Foundation Trust Hospital, Chertsey, Surrey, KT16 0PZ, United Kingdom; Department of Hum

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April 2015

Androgens inhibit the osteogenic response to mechanical loading in adult male mice.

Endocrinology 2015 Apr 5;156(4):1343-53. Epub 2015 Feb 5.

Division of Clinical and Experimental Endocrinology (M.S., F.J., L.D., G.C., D.V.), Department of Clinical and Experimental Medicine, Molecular Endocrinology Laboratory (M.R.L., V.D., F.C.), Department of Cellular and Molecular Medicine, and Division of Gerontology and Geriatrics (M.R.L.), Department of Clinical and Experimental Medicine, KU Leuven, 3000 Leuven, Belgium; School of Veterinary Science (P.D.), University of Bristol, Bristol BS13NY, United Kingdom; and Laboratory of Pathophysiology (G.J.B., P.C.D.), University of Antwerp, B-2610 Antwerp, Belgium.

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http://dx.doi.org/10.1210/en.2014-1673DOI Listing
April 2015

Sex steroid actions in male bone.

Endocr Rev 2014 Dec 9;35(6):906-60. Epub 2014 Sep 9.

Clinical and Experimental Endocrinology (D.V.) and Gerontology and Geriatrics (M.R.L., E.G.), Department of Clinical and Experimental Medicine; Laboratory of Molecular Endocrinology, Department of Cellular and Molecular Medicine (M.R.L., F.C.); and Centre for Metabolic Bone Diseases (D.V., M.R.L., E.G.), KU Leuven, B-3000 Leuven, Belgium; and Center for Bone and Arthritis Research (M.K.L., L.V., A.E.B., C.O.), Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 413 45 Gothenburg, Sweden.

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http://dx.doi.org/10.1210/er.2014-1024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4234776PMC
December 2014

Emerging mechanisms of enzalutamide resistance in prostate cancer.

Nat Rev Urol 2014 12 16;11(12):712-6. Epub 2014 Sep 16.

Urology, Department of Development and Regeneration, University Hospitals Leuven, Herestraat 49, Leuven 3000, Belgium.

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http://dx.doi.org/10.1038/nrurol.2014.243DOI Listing
December 2014

The role of single nucleotide polymorphisms in predicting prostate cancer risk and therapeutic decision making.

Biomed Res Int 2014 19;2014:627510. Epub 2014 Feb 19.

Laboratory of Molecular Endocrinology, Department of Cellular and Molecular Medicine, KU Leuven, Campus Gasthuisberg O&N1, P.O. Box 901, Herestraat 49, 3000 Leuven, Belgium.

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http://dx.doi.org/10.1155/2014/627510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950427PMC
November 2014

Comparative genomic and transcriptomic analyses of LNCaP and C4-2B prostate cancer cell lines.

PLoS One 2014 28;9(2):e90002. Epub 2014 Feb 28.

Laboratory of Molecular Endocrinology, Department of Cellular and Molecular Medicine, University of Leuven, Campus Gasthuisberg, Leuven, Belgium.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938550PMC
October 2014

Androgen receptor antagonists for prostate cancer therapy.

Endocr Relat Cancer 2014 Aug 17;21(4):T105-18. Epub 2014 Mar 17.

Laboratory of Molecular EndocrinologyDepartment of Cellular and Molecular Medicine, Katholieke Universiteit Leuven, Herestraat 49, B-3000 Leuven, BelgiumUrologyDepartment of Development and Regeneration, University Hospitals Leuven, Herestraat 49, 3000 Leuven, BelgiumLaboratory for Structural BioinformaticsCenter for Life Science Technologies, RIKEN, Yokohama, Japan

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http://dx.doi.org/10.1530/ERC-13-0545DOI Listing
August 2014

Androgen signalling and steroid receptor crosstalk in endocrine cancers.

Endocr Relat Cancer 2014 Aug;21(4):E3-5

Molecular Endocrinology LaboratoryDepartment of Cellular and Molecular Medicine, KU Leuven, Herestraat 49, Campus GHB ON1, PO Box 901, 3000 Leuven, BelgiumDame Roma Mitchell Cancer Research LaboratoriesSchool of Medicine, University of Adelaide, Adelaide, South Australia 5000, Australia.

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http://dx.doi.org/10.1530/ERC-14-0274DOI Listing
August 2014

Androgen receptor uses relaxed response element stringency for selective chromatin binding and transcriptional regulation in vivo.

Nucleic Acids Res 2014 Apr 22;42(7):4230-40. Epub 2014 Jan 22.

Department of Physiology, Institute of Biomedicine, Biomedicum Helsinki, University of Helsinki, FI-00014 Helsinki, Finland and Department of Cellular and Molecular Medicine, Molecular Endocrinology Laboratory, Katholieke Universiteit Leuven, Campus Gasthuisberg, BE-3000 Leuven, Belgium.

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http://dx.doi.org/10.1093/nar/gkt1401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985627PMC
April 2014

Looking at nuclear receptors from a new angle.

Mol Cell Endocrinol 2014 Jan 18;382(1):97-106. Epub 2013 Sep 18.

Laboratory of Molecular Endocrinology, Department of Cellular and Molecular Medicine, KU Leuven, O&N1, Herestraat 49, 3000 Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.mce.2013.09.009DOI Listing
January 2014

Androgen regulation of the TMPRSS2 gene and the effect of a SNP in an androgen response element.

Mol Endocrinol 2013 Dec 9;27(12):2028-40. Epub 2013 Oct 9.

Molecular Endocrinology Laboratory, Department of Cellular and Molecular Medicine KU Leuven, Campus Gasthuisberg O&N1, PO Box 901, Herestraat 49, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.1210/me.2013-1098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5426606PMC
December 2013

Sensitive routine liquid chromatography-tandem mass spectrometry method for serum estradiol and estrone without derivatization.

Anal Bioanal Chem 2013 Oct 28;405(26):8569-77. Epub 2013 Jul 28.

Clinical Department of Laboratory Medicine, University Hospitals Leuven, Herestraat 49, 3000, Leuven, Belgium,

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http://dx.doi.org/10.1007/s00216-013-7259-5DOI Listing
October 2013

Osteoporosis in older men: recent advances in pathophysiology and treatment.

Best Pract Res Clin Endocrinol Metab 2013 Aug 23;27(4):527-39. Epub 2013 May 23.

Geriatric Medicine, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium; Gerontology and Geriatrics, Department of Clinical and Experimental Medicine, KU Leuven, Herestraat 49, 3000 Leuven, Belgium; Laboratory of Molecular Endocrinology, Department of Cellular and Molecular Medicine, KU Leuven, Herestraat 49, 3000 Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.beem.2013.04.010DOI Listing
August 2013

Novel insights in the regulation and mechanism of androgen action on bone.

Curr Opin Endocrinol Diabetes Obes 2013 Jun;20(3):240-4

Clinical and Experimental Endocrinology, Department of Experimental Medicine, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1097/MED.0b013e32835f7d04DOI Listing
June 2013

The genomic landscape of prostate cancer.

Int J Mol Sci 2013 May 24;14(6):10822-51. Epub 2013 May 24.

Molecular Endocrinology Laboratory, Department of Cellular and Molecular Medicine, University of Leuven, Campus Gasthuisberg, Herestraat 49, P.O. Box 901, 3000 Leuven, Belgium.

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http://dx.doi.org/10.3390/ijms140610822DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709705PMC
May 2013

The discovery of novel human androgen receptor antagonist chemotypes using a combined pharmacophore screening procedure.

ChemMedChem 2013 Apr 21;8(4):644-51. Epub 2013 Feb 21.

Zhang Initiative Research Unit, Advanced Science Institute, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.

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http://dx.doi.org/10.1002/cmdc.201200549DOI Listing
April 2013

Androgen receptor (AR) in osteocytes is important for the maintenance of male skeletal integrity: evidence from targeted AR disruption in mouse osteocytes.

J Bone Miner Res 2012 Dec;27(12):2535-43

Clinical and Experimental Endocrinology, Department of Experimental Medicine, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1002/jbmr.1713DOI Listing
December 2012

A role for selective androgen response elements in the development of the epididymis and the androgen control of the 5α reductase II gene.

FASEB J 2012 Oct 13;26(10):4360-72. Epub 2012 Jul 13.

Department of Cellular and Molecular Medicine, Katholieke Univesiteit Leuven, Campus Gasthuisberg O&N1 P.O. Box 901, Herestraat 49, 3000 Leuven, Belgium.

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http://dx.doi.org/10.1096/fj.11-202283DOI Listing
October 2012

Variations in the exome of the LNCaP prostate cancer cell line.

Prostate 2012 Sep 27;72(12):1317-27. Epub 2011 Dec 27.

Molecular Endocrinology Laboratory, Department of Molecular Cell Biology, University of Leuven, 3000 Leuven, Belgium.

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http://dx.doi.org/10.1002/pros.22480DOI Listing
September 2012

Evidence for DNA-binding domain--ligand-binding domain communications in the androgen receptor.

Mol Cell Biol 2012 Aug 29;32(15):3033-43. Epub 2012 May 29.

Laboratory of Molecular Endocrinology, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1128/MCB.00151-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3434514PMC
August 2012

The hinge region in androgen receptor control.

Mol Cell Endocrinol 2012 Jul 2;358(1):1-8. Epub 2012 Mar 2.

Molecular Endocrinology Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, Campus Gasthuisberg O&N1, Herestraat 49, 3000 Leuven, Belgium.

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http://dx.doi.org/10.1016/j.mce.2012.02.019DOI Listing
July 2012

Identification and characterization of MEL-3, a novel AR antagonist that suppresses prostate cancer cell growth.

Mol Cancer Ther 2012 Jun 10;11(6):1257-68. Epub 2012 Apr 10.

Laboratory of Molecular Endocrinology, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1158/1535-7163.MCT-11-0763DOI Listing
June 2012

Androgens and skeletal muscle: cellular and molecular action mechanisms underlying the anabolic actions.

Cell Mol Life Sci 2012 May 19;69(10):1651-67. Epub 2011 Nov 19.

Molecular Endocrinology Laboratory, Department of Molecular Cell Biology, K.U. Leuven, Campus Gasthuisberg, O&N1, Herestraat 49, Leuven, Belgium.

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http://link.springer.com/10.1007/s00018-011-0883-3
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May 2012

Inhibition of cathepsin K for treatment of osteoporosis.

Curr Osteoporos Rep 2012 Mar;10(1):73-9

Leuven University Division of Geriatric Medicine and Centre for Metabolic Bone Diseases, UZ Leuven campus Gasthuisberg, Herestraat 49, B-3000 Leuven, Belgium.

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http://link.springer.com/10.1007/s11914-011-0085-9
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March 2012

Structural basis for nuclear hormone receptor DNA binding.

Mol Cell Endocrinol 2012 Jan 27;348(2):411-7. Epub 2011 Jul 27.

Molecular Endocrinology Laboratory, Department Molecular Cell Biology, Campus GHB, ON1, Herestraat 49, 3000 Leuven, Belgium.

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http://dx.doi.org/10.1016/j.mce.2011.07.025DOI Listing
January 2012

Regulation of androgen receptor-dependent transcription by coactivator MED1 is mediated through a newly discovered noncanonical binding motif.

J Biol Chem 2012 Jan 18;287(2):858-70. Epub 2011 Nov 18.

Department of Physiology and Biophysics, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey 08854, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M111.304519
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http://dx.doi.org/10.1074/jbc.M111.304519DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3256875PMC
January 2012

Identification and characterization of androgen response elements.

Methods Mol Biol 2011 ;776:81-93

Department of Molecular Cell Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA.

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http://dx.doi.org/10.1007/978-1-61779-243-4_6DOI Listing
November 2011

Calcium and vitamin d supplementation in men.

J Osteoporos 2011 25;2011:875249. Epub 2011 Aug 25.

Division of Geriatric Medicine, Leuven University Hospital, Herestraat 49, 3000 Leuven, Belgium.

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http://dx.doi.org/10.4061/2011/875249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3163142PMC
November 2011

Testosterone and the male skeleton: a dual mode of action.

J Osteoporos 2011 14;2011:240328. Epub 2011 Sep 14.

Experimental Medicine and Endocrinology, Department of Experimental Medicine, K. U. Leuven, 300 Leuven, Belgium.

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http://www.hindawi.com/journals/jos/2011/240328/
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173882PMC
November 2011

NBBS isolated from Pygeum africanum bark exhibits androgen antagonistic activity, inhibits AR nuclear translocation and prostate cancer cell growth.

Invest New Drugs 2010 Dec 23;28(6):729-43. Epub 2009 Sep 23.

Institute of Human Genetics, Jena University Hospital, 07743, Jena, Germany.

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http://dx.doi.org/10.1007/s10637-009-9304-yDOI Listing
December 2010

A 629RKLKK633 motif in the hinge region controls the androgen receptor at multiple levels.

Cell Mol Life Sci 2010 Jun 26;67(11):1919-27. Epub 2010 Feb 26.

Molecular Endocrinology Laboratory, Department of Molecular Cell Biology, Catholic University of Leuven, Campus Gasthuisberg O&N1, Herestraat 49, Box 901, 3000, Leuven, Belgium.

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http://dx.doi.org/10.1007/s00018-010-0302-1DOI Listing
June 2010

The rules of DNA recognition by the androgen receptor.

Mol Endocrinol 2010 May 19;24(5):898-913. Epub 2010 Mar 19.

Katholieke Universiteit Leuven, Campus Gasthuisberg, O/N1, Herestraat 49, 3000 Leuven, Belgium.

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http://dx.doi.org/10.1210/me.2009-0310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5417492PMC
May 2010

Diverse roles of androgen receptor (AR) domains in AR-mediated signaling.

Nucl Recept Signal 2008 Jun 27;6:e008. Epub 2008 Jun 27.

Molecular Endocrinology Laboratory, Campus Gasthuisberg, University of Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1621/nrs.06008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2443950PMC
June 2008

Identification of androgen-selective androgen-response elements in the human aquaporin-5 and Rad9 genes.

Biochem J 2008 May;411(3):679-86

Laboratory of Molecular Endocrinology, Department of Molecular Cell Biology, Faculty of Medicine, Catholic University of Leuven, Campus Gasthuisberg, Onderwijs en Navorsing I, Box 901, Herestraat 49, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.1042/BJ20071352DOI Listing
May 2008

Squalene synthase, a determinant of Raft-associated cholesterol and modulator of cancer cell proliferation.

J Biol Chem 2007 Jun 5;282(26):18777-85. Epub 2007 May 5.

Laboratory for Experimental Medicine and Endocrinology, Department of Molecular Cell Biology, Katholieke Universiteit Leuven, Herestraat 49, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.1074/jbc.M611763200DOI Listing
June 2007

The hinge region regulates DNA binding, nuclear translocation, and transactivation of the androgen receptor.

Cancer Res 2007 May;67(9):4514-23

Molecular Endocrinology Laboratory, Department of Molecular Cell Biology, Faculty of Medicine, Campus Gasthuisberg, University of Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-1701DOI Listing
May 2007

Loss of androgen receptor binding to selective androgen response elements causes a reproductive phenotype in a knockin mouse model.

Proc Natl Acad Sci U S A 2007 Mar 12;104(12):4961-6. Epub 2007 Mar 12.

Molecular Endocrinology Laboratory, Department of Molecular Cell Biology, Catholic University of Leuven, Campus Gasthuisberg, Herestraat 49, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.1073/pnas.0610814104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1829247PMC
March 2007

Interplay between two hormone-independent activation domains in the androgen receptor.

Cancer Res 2006 Jan;66(1):543-53

Molecular Endocrinology Laboratory, Faculty of Medicine, Campus Gasthuisberg, University of Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-2389DOI Listing
January 2006

Altered Vitamin D receptor-coactivator interactions reflect superagonism of Vitamin D analogs.

J Steroid Biochem Mol Biol 2005 Oct 20;97(1-2):65-8. Epub 2005 Jul 20.

Laboratorium voor Experimentele Geneeskunde en Endocrinologie, Katholieke Universiteit Leuven, Gasthuisberg, Herestraat 49, B-3000 Leuven, Belgium.

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http://linkinghub.elsevier.com/retrieve/pii/S096007600500233
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October 2005

Comparison of different androgen bioassays in the screening for environmental (anti)androgenic activity.

Environ Toxicol Chem 2005 Oct;24(10):2646-56

Division of Biochemistry, Faculty of Medicine, Campus Gasthuisberg, K.U.Leuven, Herestraat 49, B-3000 Leuven, Belgium.

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October 2005

Superagonistic action of 14-epi-analogs of 1,25-dihydroxyvitamin D explained by vitamin D receptor-coactivator interaction.

Mol Pharmacol 2005 May 22;67(5):1566-73. Epub 2005 Feb 22.

Laboratorium voor Experimentele Geneeskunde en Endocrinologie, Katholieke Universiteit Leuven, Belgium.

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http://dx.doi.org/10.1124/mol.104.008730DOI Listing
May 2005

DNA recognition by nuclear receptors.

Essays Biochem 2004 ;40:59-72

Department of Molecular Cell Biology, Faculty of Medicine, Campus GHB O/N, Herestraat 49, 3000 Leuven, Belgium.

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February 2005

The hinge region of the androgen receptor plays a role in proteasome-mediated transcriptional activation.

Ann N Y Acad Sci 2004 Dec;1030:587-92

Biochemistry Division, Laboratory of Molecular Endocrinology, Catholic University of Leuven, Campus Gasthuisberg O&N, Herestraat 49, Leuven, 3000, Belgium.

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http://doi.wiley.com/10.1196/annals.1329.068
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http://dx.doi.org/10.1196/annals.1329.068DOI Listing
December 2004

Identification of an androgen response element in intron 8 of the sterol regulatory element-binding protein cleavage-activating protein gene allowing direct regulation by the androgen receptor.

J Biol Chem 2004 Jul 6;279(29):30880-7. Epub 2004 May 6.

Laboratory for Experimental Medicine and Endocrinology, Faculty of Medicine, Onderwijs en Navorsing, Gasthuisberg, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.1074/jbc.M401615200DOI Listing
July 2004