Frank C Sciurba

Frank C Sciurba

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Frank C Sciurba

Publications by authors named "Frank C Sciurba"

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Benralizumab for the Prevention of COPD Exacerbations.

N Engl J Med 2019 09 20;381(11):1023-1034. Epub 2019 May 20.

From the Department of Thoracic Medicine and Surgery, Lewis Katz School of Medicine, Temple University, Philadelphia (G.J.C.); Pulmonary and Critical Care Division, Brigham and Women's Hospital, Harvard Medical School, Boston (B.R.C.); the Institute for Lung Health, Leicester National Institute for Health Research Biomedical Research Centre, Department of Respiratory Sciences, University of Leicester, Leicester (C.E.B.), the University of Manchester, Manchester University NHS Hospital Trust, Manchester (D.S.), and the Respiratory Medicine Unit, Nuffield Department of Medicine, University of Oxford, Oxford (M.B.) - all in the United Kingdom; Respiratory Institute, Hospital Clinic, University of Barcelona, Institut D'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red (CIBER) Enfermedades Respiratorias, Barcelona (A.A.); the Department of Medical Sciences, University of Ferrara, Ferrara, Italy (A.P.); the Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, BC, Canada (D.D.S.); the Department of Medicine, Pulmonary and Critical Care Medicine, University Medical Center Giessen and Marburg, Philipps-Universität Marburg, German Center for Lung Research (DZL), Marburg, Germany (C.F.V.); University of Pittsburgh School of Medicine, Pittsburgh (F.C.S.); the Department of Respiratory Medicine, Bispebjerg University Hospital, Copenhagen (V.B.); Kishiwada City Hospital, Osaka, Japan (M.K.); the Departamento de Investigación en Tabaquismo y EPOC, Instituto Nacional de Enfermedades Respiratorias, Ismael Cosio Villegas, Mexico City (A.R.-V.); the Division of Respiratory and Chest Medicine, E-Da Hospital and I-Shou University, Kaohsiung, Taiwan (Y.-F.W.); the Department of Respiratory Medicine and Allergology, Skane University Hospital, Lund University, Lund, Sweden (L.B.); and AstraZeneca, Gaithersburg, MD (V.H.S., M.J., S.O., N.M., P.N., M.G., U.J.M.).

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http://dx.doi.org/10.1056/NEJMoa1905248DOI Listing
September 2019

The Peak Index: Spirometry Metric for Airflow Obstruction Severity and Heterogeneity.

Ann Am Thorac Soc 2019 Aug;16(8):982-989

10Department of Electrical and Computer Engineering, University of Alabama at Birmingham, Birmingham, Alabama.

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http://dx.doi.org/10.1513/AnnalsATS.201811-812OCDOI Listing
August 2019

Loss of skin elasticity is associated with pulmonary emphysema, biomarkers of inflammation, and matrix metalloproteinase activity in smokers.

Respir Res 2019 Jun 24;20(1):128. Epub 2019 Jun 24.

Division of Pulmonary Allergy and Critical Care Medicine Department of Medicine, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Kaufmann Building, Suite 1211, 3471 Fifth Ave, Pittsburgh, PA, 15213, USA.

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http://dx.doi.org/10.1186/s12931-019-1098-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591816PMC
June 2019

Bronchoscopic device intervention in chronic obstructive pulmonary disease.

Curr Opin Pulm Med 2019 Mar;25(2):201-210

Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

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http://dx.doi.org/10.1097/MCP.0000000000000561DOI Listing
March 2019

Diagnosis and Outpatient Management of Chronic Obstructive Pulmonary Disease: A Review.

JAMA 2019 Feb;321(8):786-797

Division of Pulmonary, Department of Medicine, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1001/jama.2019.0131DOI Listing
February 2019

Reply to: The LIBERATE trial: Options to Reduce the Risk of Post-Procedural Pneumothorax and Length of Stay.

Am J Respir Crit Care Med 2018 Sep 19. Epub 2018 Sep 19.

University Medical Center Groningen, Pulmonary diseases, Groningen, Netherlands.

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http://dx.doi.org/10.1164/rccm.201808-1477LEDOI Listing
September 2018

Mediastinal and Subcutaneous Chest Fat Are Differentially Associated with Emphysema Progression and Clinical Outcomes in Smokers.

Respiration 2017 15;94(6):501-509. Epub 2017 Sep 15.

Department of General Internal Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1159/000479886DOI Listing
August 2018

Mepolizumab for Eosinophilic COPD.

N Engl J Med 2018 02;378(7):681-683

Oxford Respiratory NIHR Biomedical Research Centre, Oxford, United Kingdom

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http://dx.doi.org/10.1056/NEJMc1715454DOI Listing
February 2018

Impact of neurological level and spinal curvature on pulmonary function in adults with spina bifida.

J Pediatr Rehabil Med 2018 ;11(4):243-254

Human Engineering Research Laboratories, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, PA, USA.

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http://dx.doi.org/10.3233/PRM-179451DOI Listing
January 2018

The St. George's Respiratory Questionnaire Appendix to the Food and Drug Administration Draft Guidance on COPD: Why a Small Step Forward Is So Important.

Chest 2017 11;152(5):914-916

Division of Pulmonary Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA.

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http://dx.doi.org/10.1016/j.chest.2017.07.040DOI Listing
November 2017

Mepolizumab for Eosinophilic Chronic Obstructive Pulmonary Disease.

N Engl J Med 2017 10 11;377(17):1613-1629. Epub 2017 Sep 11.

From the Respiratory Medicine Unit and Oxford Respiratory Biomedical Research Centre, Nuffield Department of Medicine, University of Oxford, Oxford (I.D.P.), and Clinical Statistics, GlaxoSmithKline, Uxbridge (B.M.) - both in the United Kingdom; the Department of Respiratory Medicine and CIC Nord, Aix-Marseille University, Marseille, France (P.C.); the Department of Thoracic Medicine and Surgery, Lewis Katz School of Medicine at Temple University, Philadelphia (G.J.C.); the Department of Pulmonary Medicine and Tuberculosis, University of Groningen and University Medical Center Groningen, Groningen, the Netherlands (H.A.M.K.); the Pulmonary Department, Mainz University Hospital, Mainz, Germany (S.K.); the Division of Pulmonary, Allergy, and Critical Care Medicine, Duke University, Durham (N.L.), and the Respiratory Medical Franchise (F.C.A.) and the Respiratory Therapeutic Area (E.S.B., S.S.H., D.B.R., S.W.Y.), GlaxoSmithKline, Research Triangle Park - all in North Carolina; the Department of Pneumology, Centre Hospitalier Universitaire-Université Catholique de Louvain, Namur, Namur, Belgium (J.-B.M.); the Division of Allergology and Respiratory Medicine, Showa University School of Medicine, Tokyo (H.S.); and the Department of Medicine, University of Pittsburgh, Pittsburgh (F.C.S.).

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http://dx.doi.org/10.1056/NEJMoa1708208DOI Listing
October 2017

EnRAGEed Kidneys in Chronic Obstructive Pulmonary Disease?

Am J Respir Crit Care Med 2017 06;195(11):1411-1413

1 Emphysema COPD Research Center of the Division of Pulmonary, Allergy, and Critical Care Medicine University of Pittsburgh School of Medicine Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1164/rccm.201701-0173EDDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955069PMC
June 2017

Determining the Role of Dynamic Hyperinflation in Patients with Severe Chronic Obstructive Pulmonary Disease.

Respiration 2015 10;90(4):306-13. Epub 2015 Sep 10.

Research Institute for Asthma and COPD, University Medical Center Groningen, Department of Pulmonary Diseases, University of Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1159/000439056DOI Listing
September 2016

COPD phenotypes in a lung cancer screening population.

Clin Respir J 2016 Jan 28;10(1):48-53. Epub 2014 Jul 28.

Department of Pulmonary and Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1111/crj.12180DOI Listing
January 2016

Bronchoscopic Lung Volume Reduction in COPD: Lessons in Implementing Clinically Based Precision Medicine.

JAMA 2016 Jan;315(2):139-41

Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1001/jama.2015.17714DOI Listing
January 2016

Integrative phenotyping framework (iPF): integrative clustering of multiple omics data identifies novel lung disease subphenotypes.

BMC Genomics 2015 Nov 11;16:924. Epub 2015 Nov 11.

Department of Internal Medicine (Pulmonary, Critical Care and Sleep Medicine), Yale School of Medicine, New Haven, CT, 06520, USA.

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http://dx.doi.org/10.1186/s12864-015-2170-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4642618PMC
November 2015

Pulmonary fissure integrity and collateral ventilation in COPD patients.

PLoS One 2014 6;9(5):e96631. Epub 2014 May 6.

Division of Pulmonary Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0096631PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011857PMC
June 2015

Biomechanical properties of the skin in cutis laxa.

J Invest Dermatol 2014 Nov 20;134(11):2836-2838. Epub 2014 May 20.

Department of Human Genetics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0022202X153652
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http://dx.doi.org/10.1038/jid.2014.224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199921PMC
November 2014

Bidirectional elastic image registration using B-spline affine transformation.

Comput Med Imaging Graph 2014 Jun 25;38(4):306-14. Epub 2014 Jan 25.

Department of Radiology, University of Pittsburgh, Pittsburgh, PA 15213, United States; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15213, United States. Electronic address:

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http://dx.doi.org/10.1016/j.compmedimag.2014.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019704PMC
June 2014

Down-regulated peroxisome proliferator-activated receptor γ (PPARγ) in lung epithelial cells promotes a PPARγ agonist-reversible proinflammatory phenotype in chronic obstructive pulmonary disease (COPD).

J Biol Chem 2014 Mar 24;289(10):6383-93. Epub 2013 Dec 24.

From the Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213 and.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M113.536805
Publisher Site
http://dx.doi.org/10.1074/jbc.M113.536805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945305PMC
March 2014

Considerations and pitfalls in phenotyping and reclassification of chronic obstructive pulmonary disease.

Transl Res 2013 Oct 3;162(4):252-7. Epub 2013 Aug 3.

Division of Pulmonary Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA.

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http://dx.doi.org/10.1016/j.trsl.2013.07.006DOI Listing
October 2013

Assessment of lung volume collapsibility in chronic obstructive lung disease patients using CT.

Eur Radiol 2013 Jun 15;23(6):1564-72. Epub 2013 Mar 15.

Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15213, USA.

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http://dx.doi.org/10.1007/s00330-012-2746-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657332PMC
June 2013

A combinatorial F box protein directed pathway controls TRAF adaptor stability to regulate inflammation.

Nat Immunol 2013 May 31;14(5):470-9. Epub 2013 Mar 31.

Department of Medicine, Acute Lung Injury Center of Excellence, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

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http://dx.doi.org/10.1038/ni.2565DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3631463PMC
May 2013

Response.

Chest 2013 May;143(5):1517-1518

Emphysema COPD Research Center, Division of Pulmonary, Allergy, and Critical Care Medicine, Pittsburgh, PA. Electronic address:

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http://dx.doi.org/10.1378/chest.13-0404DOI Listing
May 2013

Optimal threshold in CT quantification of emphysema.

Eur Radiol 2013 Apr 1;23(4):975-84. Epub 2012 Nov 1.

Department of Radiology, University of Pittsburgh, Pittsburgh, PA 15213, USA.

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http://dx.doi.org/10.1007/s00330-012-2683-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573224PMC
April 2013

Computerized identification of airway wall in CT examinations using a 3D active surface evolution approach.

Med Image Anal 2013 Apr 29;17(3):283-96. Epub 2012 Nov 29.

Department of Radiology, University of Pittsburgh, Pittsburgh, PA 15213, USA.

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http://dx.doi.org/10.1016/j.media.2012.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3606689PMC
April 2013

Deglutitive subglottic air pressure and respiratory system recoil.

Dysphagia 2012 Dec 24;27(4):452-9. Epub 2012 Jan 24.

Department of Otolaryngology, Eye and Ear Institute, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.

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http://dx.doi.org/10.1007/s00455-011-9389-2DOI Listing
December 2012

Optimizing the 6-min walk test as a measure of exercise capacity in COPD.

Chest 2012 Dec;142(6):1545-1552

Emphysema Research Center, Division of Pulmonary and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA. Electronic address:

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http://dx.doi.org/10.1378/chest.11-2702DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515028PMC
December 2012

Clinical year in review III: asthma, chronic obstructive pulmonary disease, environmental and occupational lung disease, and ethics and end-of-life care.

Proc Am Thorac Soc 2012 Oct;9(4):197-203

Division of Pulmonary and Critical Care Medicine, National Jewish Health, 1400 Jackson St., J-201, Denver, CO 80206, USA.

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http://dx.doi.org/10.1513/pats.201206-032TTDOI Listing
October 2012

Elevated N-terminal pro-brain natriuretic peptide is associated with mortality in tobacco smokers independent of airflow obstruction.

PLoS One 2011 7;6(11):e27416. Epub 2011 Nov 7.

Division of Pulmonary and Critical Care Medicine, Geisinger Medical Center, Danville, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0027416PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210169PMC
May 2012

Distribution of Pneumocystis jirovecii in lungs from colonized COPD patients.

Diagn Microbiol Infect Dis 2011 Sep;71(1):24-8

Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.

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http://dx.doi.org/10.1016/j.diagmicrobio.2011.05.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159032PMC
September 2011

Quantitative computed tomography analysis, airflow obstruction, and lung cancer in the pittsburgh lung screening study.

J Thorac Oncol 2011 Jul;6(7):1200-5

Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S15560864153103
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http://dx.doi.org/10.1097/JTO.0b013e318219aa93DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157578PMC
July 2011

A new perspective on optimal care for patients with COPD.

Prim Care Respir J 2011 Jun;20(2):205-9

Department of Pulmonary Medicine and Tuberculosis, University Medical Center Groningen, University of Groningen, The Netherlands.

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http://dx.doi.org/10.4104/pcrj.2011.00041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6549820PMC
June 2011

A differential geometric approach to automated segmentation of human airway tree.

IEEE Trans Med Imaging 2011 Feb 16;30(2):266-78. Epub 2010 Sep 16.

Imaging Research Division, Department of Radiology, University of Pittsburgh, Pittsburgh, PA 15213, USA.

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http://ieeexplore.ieee.org/document/5575430/
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http://dx.doi.org/10.1109/TMI.2010.2076300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3271357PMC
February 2011

Perfusion scintigraphy and patient selection for lung volume reduction surgery.

Am J Respir Crit Care Med 2010 Oct 10;182(7):937-46. Epub 2010 Jun 10.

Division of Pulmonary and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA.

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http://dx.doi.org/10.1164/rccm.201001-0043OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2970864PMC
October 2010

Chronic obstructive pulmonary disease phenotypes: the future of COPD.

Am J Respir Crit Care Med 2010 Sep 3;182(5):598-604. Epub 2010 Jun 3.

University of Michigan-Pulmonary and Critical Care, 1500 E. Medical Center Drive, 3916 Taubman, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1164/rccm.200912-1843CCDOI Listing
September 2010

A randomized study of endobronchial valves for advanced emphysema.

N Engl J Med 2010 Sep;363(13):1233-44

University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.

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http://dx.doi.org/10.1056/NEJMoa0900928DOI Listing
September 2010

Computerized assessment of pulmonary fissure integrity using high resolution CT.

Med Phys 2010 Sep;37(9):4661-72

Department of Radiology, Imaging Research Center, University of Pittsburgh, 3362 Fifth Avenue, Pittsburgh, Pennsylvania 15213, USA.

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http://doi.wiley.com/10.1118/1.3475937
Publisher Site
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2937051PMC
http://dx.doi.org/10.1118/1.3475937DOI Listing
September 2010

Physiological and computed tomographic predictors of outcome from lung volume reduction surgery.

Am J Respir Crit Care Med 2010 Mar 3;181(5):494-500. Epub 2009 Dec 3.

Pulmonary and Critical Care Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.

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http://dx.doi.org/10.1164/rccm.200906-0911OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2830400PMC
March 2010