Frank C Brosius

Frank C Brosius

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Frank C Brosius

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The Promise of Systems Biology for Diabetic Kidney Disease.

Adv Chronic Kidney Dis 2018 03;25(2):202-213

Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI; Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI; and the Department of Medicine, University of Arizona, Tucson, AZ.

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http://dx.doi.org/10.1053/j.ackd.2017.10.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877319PMC
March 2018

Podocyte-specific JAK2 overexpression worsens diabetic kidney disease in mice.

Kidney Int 2017 10 26;92(4):909-921. Epub 2017 May 26.

Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA; Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, USA. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2017.03.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610635PMC
October 2017

JAK inhibition in the treatment of diabetic kidney disease.

Diabetologia 2016 08 22;59(8):1624-7. Epub 2016 Jun 22.

Department of Internal Medicine, University of Michigan Medical School, 5520 MSRB1, 1150 W. Medical Center Dr., Ann Arbor, MI, 48109-5680, USA.

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http://dx.doi.org/10.1007/s00125-016-4021-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942738PMC
August 2016

Structural Predictors of Loss of Renal Function in American Indians with Type 2 Diabetes.

Clin J Am Soc Nephrol 2016 Feb 20;11(2):254-61. Epub 2016 Jan 20.

Diabetes Epidemiology and Clinical Research Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona;

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http://dx.doi.org/10.2215/CJN.05760515DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741038PMC
February 2016

Prevention of lithium-associated renal failure: recent evidence.

Lancet Psychiatry 2015 Dec;2(12):1045-7

University of Michigan, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1016/S2215-0366(15)00498-8DOI Listing
December 2015

Targeted Lipidomic and Transcriptomic Analysis Identifies Dysregulated Renal Ceramide Metabolism in a Mouse Model of Diabetic Kidney Disease.

J Proteomics Bioinform 2015 Oct 18;Suppl 14. Epub 2015 May 18.

Division of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.

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http://dx.doi.org/10.4172/jpb.S14-002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712744PMC
October 2015

MicroRNA-21 in glomerular injury.

J Am Soc Nephrol 2015 Apr 21;26(4):805-16. Epub 2014 Aug 21.

Internal Medicine, University of Michigan, Ann Arbor, Michigan; Department of Medicine, Albert Einstein College of Medicine, Bronx, New York;

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http://dx.doi.org/10.1681/ASN.2013121274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4378097PMC
April 2015

Maintenance of GLUT4 expression in smooth muscle prevents hypertension-induced changes in vascular reactivity.

Physiol Rep 2015 Feb 12;3(2). Epub 2015 Feb 12.

Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA Department of Physiology, University of Michigan Medical School, Ann Arbor, Michigan, USA.

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http://dx.doi.org/10.14814/phy2.12299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393207PMC
February 2015

JAK inhibition and progressive kidney disease.

Curr Opin Nephrol Hypertens 2015 Jan;24(1):88-95

aDepartments of Internal Medicine and Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA bDepartment of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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http://dx.doi.org/10.1097/MNH.0000000000000079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673981PMC
January 2015

Research capacity. Enabling the genomic revolution in Africa.

Authors:
Charles Rotimi Akin Abayomi Alash'le Abimiku Victoria May Adabayeri Clement Adebamowo Ezekiel Adebiyi Adebowale D Ademola Adebowale Adeyemo Dwomoa Adu Dissou Affolabi Godfred Agongo Samuel Ajayi Sally Akarolo-Anthony Rufus Akinyemi Albert Akpalu Marianne Alberts Orlando Alonso Betancourt Ahmed Mansour Alzohairy Gobena Ameni Olukemi Amodu Gabriel Anabwani Kristian Andersen Fatiu Arogundade Oyedunni Arulogun Danny Asogun Rasheed Bakare Naby Balde Mary Lynn Baniecki Christine Beiswanger Alia Benkahla Lara Bethke Micheal Boehnke Vincent Boima James Brandful Andrew I Brooks Frank C Brosius Chester Brown Bruno Bucheton David T Burke Barrington G Burnett Stacy Carrington-Lawrence Nadia Carstens John Chisi Alan Christoffels Richard Cooper Heather Cordell Nigel Crowther Talishiea Croxton Jantina de Vries Leslie Derr Peter Donkor Seydou Doumbia Audrey Duncanson Ivy Ekem Ahmed El Sayed Mark E Engel John C K Enyaru Dean Everett Faisal M Fadlelmola Eyitayo Fakunle Kenneth H Fischbeck Anne Fischer Onikepe Folarin Junaid Gamieldien Robert F Garry Simani Gaseitsiwe Rasheed Gbadegesin Anita Ghansah Maria Giovanni Parham Goesbeck F Xavier Gomez-Olive Donald S Grant Ravnit Grewal Mark Guyer Neil A Hanchard Christian T Happi Scott Hazelhurst Branwen J Hennig Christiane Hertz- Fowler Winston Hide Friedhelm Hilderbrandt Christopher Hugo-Hamman Muntaser E Ibrahim Regina James Yasmina Jaufeerally-Fakim Carolyn Jenkins Ute Jentsch Pan-Pan Jiang Moses Joloba Victor Jongeneel Fourie Joubert Mukthar Kader Kathleen Kahn Pontiano Kaleebu Saidi H Kapiga Samar Kamal Kassim Ishmael Kasvosve Jonathan Kayondo Bernard Keavney Adeodata Kekitiinwa Sheik Humarr Khan Paul Kimmel Mary-Claire King Robert Kleta Mathurin Koffi Jeffrey Kopp Matthias Kretzler Judit Kumuthini Samuel Kyobe Catherine Kyobutungi Daniel T Lackland Karen A Lacourciere Guida Landouré Rita Lawlor Thomas Lehner Maia Lesosky Naomi Levitt Katherine Littler Zane Lombard Jeanne F Loring Sylvester Lyantagaye Annette Macleod Ebony B Madden Chengetai R Mahomva Julie Makani Manmak Mamven Marape Marape Graeme Mardon Patricia Marshall Darren P Martin Daniel Masiga Robin Mason Michael Mate-Kole Enock Matovu Mary Mayige Bongani M Mayosi Jean Claude Mbanya Sheryl A McCurdy Mark I McCarthy Helen McIlleron S O Mc'Ligeyo Corrine Merle Ana Olga Mocumbi Charles Mondo John V Moran Ayesha Motala Marva Moxey-Mims Wata Sununguko Mpoloka Chisomo L Msefula Thuli Mthiyane Nicola Mulder Gebregziab her Mulugeta Dieuodonne Mumba John Musuku Mo Nagdee Oyekanmi Nash Daouda Ndiaye Anh Quynh Nguyen Mark Nicol Oathokwa Nkomazana Shane Norris Betty Nsangi Alexander Nyarko Moffat Nyirenda Eileen Obe Reginald Obiakor Abraham Oduro Solomon F Ofori-Acquah Okechukwu Ogah Stephen Ogendo Kwaku Ohene-Frempong Akinlolu Ojo Timothy Olanrewaju John Oli Charlotte Osafo Odile Ouwe Missi Oukem-Boyer Bruce Ovbiagele Andrew Owen Mayowa Ojo Owolabi Lukman Owolabi Ellis Owusu-Dabo Guillaume Pare Rulan Parekh Hugh G Patterton Margaret B Penno Jane Peterson Rembert Pieper Jacob Plange-Rhule Martin Pollak Julia Puzak Rajkumar S Ramesar Michele Ramsay Rebekah Rasooly Shiksha Reddy Pardis C Sabeti Kwamena Sagoe Tunde Salako Oumar Samassékou Manjinder S Sandhu Osman Sankoh Fred Stephen Sarfo Marie Sarr Gasnat Shaboodien Issa Sidibe Gustave Simo Martin Simuunza Liam Smeeth Eugene Sobngwi Himla Soodyall Hermann Sorgho Oumou Sow Bah Sudha Srinivasan Dan J Stein Ezra S Susser Carmen Swanepoel Godfred Tangwa Andrew Tareila Ozlem Tastan Bishop Bamidele Tayo Nicki Tiffin Halidou Tinto Ekaete Tobin Stephen Meir Tollman Mahamadou Traoré Marsha J Treadwell Jennifer Troyer Masego Tsimako-Johnstone Vincent Tukei Ifeoma Ulasi Nzovu Ulenga Beverley van Rooyen Ablo Prudence Wachinou Salina P Waddy Alisha Wade Misaki Wayengera James Whitworth Louise Wideroff Cheryl A Winkler Sarah Winnicki Ambroise Wonkam Mengistu Yewondwos Tadase sen Nathan Yozwiak Heather Zar

Science 2014 Jun;344(6190):1346-8

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http://dx.doi.org/10.1126/science.1251546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138491PMC
June 2014

Podocytes, signaling pathways, and vascular factors in diabetic kidney disease.

Adv Chronic Kidney Dis 2014 May;21(3):304-10

Departments of Internal Medicine and Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI; and Children's Renal Unit, University of Bristol, Bristol, United Kingdom.

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http://dx.doi.org/10.1053/j.ackd.2014.03.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4075065PMC
May 2014

How to find a prognostic biomarker for progressive diabetic nephropathy.

Kidney Int 2013 Jun;83(6):996-8

Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA.

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http://dx.doi.org/10.1038/ki.2013.58DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994989PMC
June 2013

New targets for treatment of diabetic nephropathy: what we have learned from animal models.

Curr Opin Nephrol Hypertens 2013 Jan;22(1):17-25

Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109-0676, USA.

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http://dx.doi.org/10.1097/MNH.0b013e32835b3766DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776427PMC
January 2013

Perspectives on systems biology applications in diabetic kidney disease.

J Cardiovasc Transl Res 2012 Aug 26;5(4):491-508. Epub 2012 Jun 26.

Division of Nephrology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109-0676, USA.

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http://dx.doi.org/10.1007/s12265-012-9382-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422674PMC
August 2012

Smooth muscle protein 22 alpha-Cre is expressed in myeloid cells in mice.

Biochem Biophys Res Commun 2012 Jun 16;422(4):639-42. Epub 2012 May 16.

Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Clinical Research Center of Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.

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http://dx.doi.org/10.1016/j.bbrc.2012.05.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377770PMC
June 2012

Do we now have a prognostic biomarker for progressive diabetic nephropathy?

J Am Soc Nephrol 2012 Mar 9;23(3):376-7. Epub 2012 Feb 9.

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http://dx.doi.org/10.1681/ASN.2012010090DOI Listing
March 2012

GLUT1 enhances mTOR activity independently of TSC2 and AMPK.

Am J Physiol Renal Physiol 2011 Sep 25;301(3):F588-96. Epub 2011 May 25.

Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, USA.

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http://dx.doi.org/10.1152/ajprenal.00472.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174561PMC
September 2011

The glomerular podocyte as a target of growth hormone action: implications for the pathogenesis of diabetic nephropathy.

Curr Diabetes Rev 2011 Jan;7(1):50-5

Pediatrics & Communicable Diseases, University of Michigan, Ann Arbor, MI 48109-0718, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007067PMC
January 2011

Susceptible mice: identifying a diabetic nephropathy disease locus using a murine model.

Authors:
Frank C Brosius

Kidney Int 2010 Sep;78(5):431-2

Department of Internal Medicine, University of Michigan Medical School, 1150 W. Medical Center Drive, Ann Arbor, MI 48109-0680, USA.

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http://dx.doi.org/10.1038/ki.2010.199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3863579PMC
September 2010

Understanding kidney disease: toward the integration of regulatory networks across species.

Semin Nephrol 2010 Sep;30(5):512-9

Department of Internal Medicine, Division of Nephrology, University of Michigan, Ann Arbor, MI 48109-0680, USA.

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http://dx.doi.org/10.1016/j.semnephrol.2010.07.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989742PMC
September 2010

A new pair of SOCS for diabetic nephropathy.

J Am Soc Nephrol 2010 May 22;21(5):723-4. Epub 2010 Apr 22.

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http://dx.doi.org/10.1681/ASN.2010030286DOI Listing
May 2010

The management of diabetic neuropathy in CKD.

Am J Kidney Dis 2010 Feb 30;55(2):365-85. Epub 2009 Dec 30.

Department of Internal Medicine, Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, MI 48109-2200, USA.

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http://dx.doi.org/10.1053/j.ajkd.2009.10.050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007054PMC
February 2010

Abnormalities in signaling pathways in diabetic nephropathy.

Expert Rev Endocrinol Metab 2010 ;5(1):51-64

Departments of Internal Medicine and Molecular and Integrative Physiology, University of Michigan Medical School, 5520 MSRB1, 1150 W. Medical Center Drive, Ann Arbor, MI 48109-0680, USA, Tel.: +1 734 764 3157, ,

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http://dx.doi.org/10.1586/eem.09.70DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2834210PMC
January 2010

GLUT1-induced cFLIP expression promotes proliferation and prevents apoptosis in vascular smooth muscle cells.

Am J Physiol Cell Physiol 2009 Sep 8;297(3):C759-65. Epub 2009 Jul 8.

Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.

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http://dx.doi.org/10.1152/ajpcell.00213.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2740397PMC
September 2009

A rapid, PPAR-gamma-dependent effect of pioglitazone on the phosphorylation of MYPT.

Am J Physiol Cell Physiol 2009 May 4;296(5):C1151-61. Epub 2009 Mar 4.

University of Michigan, Ann Arbor, MI 48109-0676, USA.

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http://www.physiology.org/doi/10.1152/ajpcell.00343.2008
Publisher Site
http://dx.doi.org/10.1152/ajpcell.00343.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2681377PMC
May 2009

New insights into the mechanisms of fibrosis and sclerosis in diabetic nephropathy.

Authors:
Frank C Brosius

Rev Endocr Metab Disord 2008 Dec;9(4):245-54

Departments of Internal Medicine, and Molecular and Integrative Physiology, University of Michigan Medical School, 5520 MSRB1, 1150 W. Medical Center Drive, Ann Arbor, MI, 48109-0680, USA.

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http://dx.doi.org/10.1007/s11154-008-9100-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776415PMC
December 2008

Is the ER stressed out in diabetic kidney disease?

J Am Soc Nephrol 2008 Nov 8;19(11):2040-2. Epub 2008 Oct 8.

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http://dx.doi.org/10.1681/ASN.2008090959DOI Listing
November 2008

Rosiglitazone treatment reduces diabetic neuropathy in streptozotocin-treated DBA/2J mice.

Endocrinology 2008 Oct 26;149(10):4928-37. Epub 2008 Jun 26.

University of Michigan, Department of Neurology, 5017 Basic Science Research Building, 109 Zina Pitcher Road, Ann Arbor, Michigan 48109-2200, USA.

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https://academic.oup.com/endo/article-lookup/doi/10.1210/en.
Publisher Site
http://dx.doi.org/10.1210/en.2008-0869DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2582925PMC
October 2008

A GSK-3/TSC2/mTOR pathway regulates glucose uptake and GLUT1 glucose transporter expression.

Am J Physiol Cell Physiol 2008 Sep 23;295(3):C836-43. Epub 2008 Jul 23.

Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109-0680, USA.

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http://dx.doi.org/10.1152/ajpcell.00554.2007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2544442PMC
September 2008

From fibrosis to sclerosis: mechanisms of glomerulosclerosis in diabetic nephropathy.

Diabetes 2008 Jun;57(6):1439-45

Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109-0680, USA.

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http://dx.doi.org/10.2337/db08-0061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4239998PMC
June 2008

Hypoxia-inducible factor-1alpha is a critical mediator of hypoxia induced apoptosis in cardiac H9c2 and kidney epithelial HK-2 cells.

BMC Cardiovasc Disord 2008 Apr 30;8. Epub 2008 Apr 30.

Department of Internal Medicine/Nephrology, University of Michigan Medical Center, Ann Arbor, MI-48109-0676, USA.

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http://bmccardiovascdisord.biomedcentral.com/articles/10.118
Publisher Site
http://dx.doi.org/10.1186/1471-2261-8-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2387135PMC
April 2008

Preserved expression of GLUT4 prevents enhanced agonist-induced vascular reactivity and MYPT1 phosphorylation in hypertensive mouse aorta.

Am J Physiol Heart Circ Physiol 2007 Jul 16;293(1):H402-8. Epub 2007 Mar 16.

Department of Internal Medicine, University of Michigan Medical School, 1150 W. Medical Center Drive, Ann Arbor, MI 48109-0676, USA.

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http://dx.doi.org/10.1152/ajpheart.00854.2006DOI Listing
July 2007

Identification of the glomerular podocyte as a target for growth hormone action.

Endocrinology 2007 May 1;148(5):2045-55. Epub 2007 Feb 1.

Department of Pediatrics, University of Michigan, Ann Arbor, Michigan 48109-0718, USA.

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http://dx.doi.org/10.1210/en.2006-1285DOI Listing
May 2007

Reduction in podocyte density as a pathologic feature in early diabetic nephropathy in rodents: prevention by lipoic acid treatment.

BMC Nephrol 2006 Mar 15;7. Epub 2006 Mar 15.

Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109-0676, USA.

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http://dx.doi.org/10.1186/1471-2369-7-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1435876PMC
March 2006

Role for GLUT1 in diabetic glomerulosclerosis.

Expert Rev Mol Med 2006 Feb 6;8(4):1-18. Epub 2006 Feb 6.

Department of Medicine, University of Chicago Hospitals, Chicago, IL, USA.

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http://dx.doi.org/10.1017/S1462399406010490DOI Listing
February 2006

Increased JNK phosphorylation and oxidative stress in response to increased glucose flux through increased GLUT1 expression in rat retinal endothelial cells.

Invest Ophthalmol Vis Sci 2005 Sep;46(9):3403-10

Departments of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1167/iovs.04-1064DOI Listing
September 2005

Immunolocalization of the proton-coupled oligopeptide transporter PEPT2 in developing rat brain.

Mol Pharm 2004 Jul-Aug;1(4):248-56

Department of Pharmaceutical Sciences, The University of Michigan, Ann Arbor, Michigan 48109-0504, USA.

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July 2005

Glucose transporters in diabetic nephropathy.

Pediatr Nephrol 2005 Apr 17;20(4):447-51. Epub 2005 Feb 17.

Departments of Internal Medicine and Physiology, University of Michigan, Ann Arbor, MI 48109-0676, USA.

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http://dx.doi.org/10.1007/s00467-004-1748-xDOI Listing
April 2005

Diabetic nephropathy: of mice and men.

Adv Chronic Kidney Dis 2005 Apr;12(2):128-45

Vanderbilt University and VA Medical Center, Nashville, TN 37232, USA.

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April 2005

Effects of PPAR-gamma ligands on vascular smooth muscle marker expression in hypertensive and normal arteries.

Am J Physiol Heart Circ Physiol 2005 Jan 2;288(1):H235-43. Epub 2004 Sep 2.

Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109-0676, USA.

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http://www.physiology.org/doi/10.1152/ajpheart.00643.2004
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http://dx.doi.org/10.1152/ajpheart.00643.2004DOI Listing
January 2005

Mouse models of diabetic nephropathy.

J Am Soc Nephrol 2005 Jan 24;16(1):27-45. Epub 2004 Nov 24.

Division of Nephrology and Department of Medicine, Vanderbilt University Medical School, S3223 MCN, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1681/ASN.2004080648DOI Listing
January 2005

Induction of antioxidant enzymes in murine podocytes precedes injury by puromycin aminonucleoside.

Kidney Int 2004 Nov;66(5):1881-9

Department of Pediatrics, University of Michigan, Ann Arbor, Michigan 48109, USA.

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http://dx.doi.org/10.1111/j.1523-1755.2004.00962.xDOI Listing
November 2004

GLUT1-deficient mice exhibit impaired endothelium-dependent vascular relaxation.

Eur J Pharmacol 2004 Aug;496(1-3):213-4

Internal Medicine, Division of Nephrology, University of Michigan Medical School, 1560 MSRB 2, 1150 W. Medical Center Drive, Ann Arbor, MI 48109-0676, USA.

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http://dx.doi.org/10.1016/j.ejphar.2004.06.022DOI Listing
August 2004

Increased vascular sensitivity and connexin43 expression after sympathetic denervation.

Cardiovasc Res 2004 May;62(2):388-96

Department of Physiology, University of Michigan, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1016/j.cardiores.2003.12.024DOI Listing
May 2004

Trophic factors and cytokines in early diabetic glomerulopathy.

Authors:
Frank C Brosius

Exp Diabesity Res 2003 Oct-Dec;4(4):225-33

Departments of Internal Medicine and Physiology, University of Michigan, Ann Arbor, Michigan 48109-0676, USA.

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http://dx.doi.org/10.1155/EDR.2003.225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2478608PMC
January 2004

Glucose transporter-1-deficient mice exhibit impaired development and deformities that are similar to diabetic embryopathy.

Proc Natl Acad Sci U S A 2003 Dec 12;100(26):15613-8. Epub 2003 Dec 12.

Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1073/pnas.2536196100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC307616PMC
December 2003

How glucose and glucose transporters protect cardiac myocytes.

Authors:
Frank C Brosius

J Mol Cell Cardiol 2003 Oct;35(10):1187-9

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October 2003

PI3-kinase-induced hyperreactivity in DOCA-salt hypertension is independent of GSK-3 activity.

Hypertension 2003 Apr 10;41(4):898-902. Epub 2003 Mar 10.

Department of Internal Medicine, University of Michigan, Ann Arbor, Mich 48109-0676, USA.

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http://dx.doi.org/10.1161/01.HYP.0000061762.58873.2FDOI Listing
April 2003

Targeted disruption of the PEPT2 gene markedly reduces dipeptide uptake in choroid plexus.

J Biol Chem 2003 Feb 6;278(7):4786-91. Epub 2002 Dec 6.

Department of Pharmaceutical Sciences, College of Pharmacy, the University of Michigan, Ann Arbor, Michigan 48109, USA.

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http://dx.doi.org/10.1074/jbc.M207397200DOI Listing
February 2003

Evidence for a novel TGF-beta1-independent mechanism of fibronectin production in mesangial cells overexpressing glucose transporters.

Diabetes 2003 Feb;52(2):527-35

Department of Internal Medicine, Division of Endocrinology, Metabolism and Pathobio-Chemistry, University of Tübingen, Germany.

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http://dx.doi.org/10.2337/diabetes.52.2.527DOI Listing
February 2003

Enhanced glycogen synthase kinase-3beta activity mediates hypoxia-induced apoptosis of vascular smooth muscle cells and is prevented by glucose transport and metabolism.

J Biol Chem 2002 Nov 27;277(44):41667-73. Epub 2002 Aug 27.

Department of Internal Medicine, University of Michigan, Ann Arbor 48109-0676, USA.

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http://dx.doi.org/10.1074/jbc.M206405200DOI Listing
November 2002

Glucose uptake and adenoviral mediated GLUT1 infection decrease hypoxia-induced HIF-1alpha levels in cardiac myocytes.

J Mol Cell Cardiol 2002 Aug;34(8):1063-73

Department of Internal Medicine, University of Michigan Medical Center, 1150 W Medical Center Drive, 1560 MSRB II, Ann Arbor, MI 48109-0676, USA.

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August 2002