Frank Arfuso

Frank Arfuso

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Encapsulated human mesenchymal stem cells (eMSCs) as a novel anti-cancer agent targeting breast cancer stem cells: Development of 3D primed therapeutic MSCs.

Int J Biochem Cell Biol 2019 May 6;110:59-69. Epub 2019 Feb 6.

Division of Cancer Stem Cells and Cardiovascular Regeneration, School of Regenerative Medicine, Manipal Academy of Higher Education (MAHE), Bangalore, 560 065, India; Curtin Medical School, Curtin University, Perth, Western Australia, 6102, Australia; Cuor Stem Cellutions Pvt Ltd, School of Regenerative Medicine, Manipal Academy of Higher Education (MAHE), Bangalore, 560 065, India. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S13572725193003
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http://dx.doi.org/10.1016/j.biocel.2019.02.001DOI Listing
May 2019

Focus on Formononetin: Anticancer Potential and Molecular Targets.

Cancers (Basel) 2019 May 1;11(5). Epub 2019 May 1.

Lake Erie College of Osteopathic Medicine, Bradenton, FL 34211, USA.

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https://www.mdpi.com/2072-6694/11/5/611
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http://dx.doi.org/10.3390/cancers11050611DOI Listing
May 2019

Epigenetic demethylation of sFRPs, with emphasis on sFRP4 activation, leading to Wnt signalling suppression and histone modifications in breast, prostate, and ovary cancer stem cells.

Int J Biochem Cell Biol 2019 Apr 30;109:23-32. Epub 2019 Jan 30.

Stem Cell and Cancer Biology Laboratory, School of Pharmacy and Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth, WA, Australia. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S13572725193002
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http://dx.doi.org/10.1016/j.biocel.2019.01.016DOI Listing
April 2019

An in vivo pharmacological study: Variation in tissue-accumulation for the drug probucol as the result of targeted microtechnology and matrix-acrylic acid optimization and stabilization techniques.

PLoS One 2019 4;14(4):e0214984. Epub 2019 Apr 4.

Biotechnology and Drug Development Research Laboratory, School of Pharmacy and Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth, Western Australia, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214984PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449070PMC
April 2019

Honokiol for cancer therapeutics: A traditional medicine that can modulate multiple oncogenic targets.

Pharmacol Res 2019 Apr 17;144:192-209. Epub 2019 Apr 17.

Cancer Biology Laboratory and DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB) Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Assam, 781039, India. Electronic address:

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http://dx.doi.org/10.1016/j.phrs.2019.04.004DOI Listing
April 2019

Oleuropein induces apoptosis via abrogating NF-κB activation cascade in estrogen receptor-negative breast cancer cells.

J Cell Biochem 2019 Mar 27;120(3):4504-4513. Epub 2018 Sep 27.

Radiobiology Research Laboratory, Singapore Nuclear Research and Safety Initiative, National University of Singapore, Singapore.

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http://dx.doi.org/10.1002/jcb.27738DOI Listing
March 2019

The expanding roles of long non-coding RNAs in the regulation of cancer stem cells.

Int J Biochem Cell Biol 2019 Mar 7;108:17-20. Epub 2019 Jan 7.

Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, 117600, Singapore. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S13572725193000
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http://dx.doi.org/10.1016/j.biocel.2019.01.003DOI Listing
March 2019

Role of Natural Products in Modulating Histone Deacetylases in Cancer.

Molecules 2019 Mar 16;24(6). Epub 2019 Mar 16.

College of Korean Medicine, Kyung Hee University, 24 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea.

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http://dx.doi.org/10.3390/molecules24061047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471757PMC
March 2019

Stability and biological testing of taurine-conjugated bile acid antioxidant microcapsules for diabetes treatment.

Ther Deliv 2019 Feb;10(2):99-106

Biotechnology & Drug Development Research Laboratory, School of Pharmacy & Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth, Western Australia, 6102, Australia.

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http://dx.doi.org/10.4155/tde-2018-0034DOI Listing
February 2019

Potential of Zerumbone as an Anti-Cancer Agent.

Molecules 2019 Feb 18;24(4). Epub 2019 Feb 18.

Cancer Biology Laboratory, DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB), Department of Biosciences & Bioengineering, Indian Institute of Technology, Guwahati, Assam 781039, India.

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http://dx.doi.org/10.3390/molecules24040734DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413012PMC
February 2019

Dysregulation of Nrf2 in Hepatocellular Carcinoma: Role in Cancer Progression and Chemoresistance.

Cancers (Basel) 2018 Dec 3;10(12). Epub 2018 Dec 3.

Molecular Toxicology Laboratory, Department of Biotechnology, Bharathiar University, Coimbatore 641 046, Tamilnadu, India.

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http://dx.doi.org/10.3390/cancers10120481DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315366PMC
December 2018

Growth hormone during in vitro fertilization in older women modulates the density of receptors in granulosa cells, with improved pregnancy outcomes.

Fertil Steril 2018 12;110(7):1298-1310

Stem Cell and Cancer Biology Laboratory, School of Pharmacy and Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth, Australia.

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http://dx.doi.org/10.1016/j.fertnstert.2018.08.018DOI Listing
December 2018

Pharmacological Utilization of Bergamottin, Derived from Grapefruits, in Cancer Prevention and Therapy.

Int J Mol Sci 2018 Dec 14;19(12). Epub 2018 Dec 14.

Department of Science in Korean Medicine, Kyung Hee University, 24 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea.

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http://dx.doi.org/10.3390/ijms19124048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321104PMC
December 2018

Stemness, Pluripotentiality, and Wnt Antagonism: sFRP4, a Wnt antagonist Mediates Pluripotency and Stemness in Glioblastoma.

Cancers (Basel) 2018 12 27;11(1). Epub 2018 Dec 27.

Division of Cancer Stem Cells and Cardiovascular and Neuronal Regeneration, School of Regenerative Medicine, Manipal Academy of Higher Education (MAHE), Bangalore 560 065, India.

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http://www.mdpi.com/2072-6694/11/1/25
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http://dx.doi.org/10.3390/cancers11010025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356444PMC
December 2018

Involvement of Bone Morphogenetic Proteins (BMP) in the Regulation of Ovarian Function.

Vitam Horm 2018 8;107:227-261. Epub 2018 Mar 8.

Stem Cell and Cancer Biology Laboratory, School of Pharmacy and Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth, WA, Australia.

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http://dx.doi.org/10.1016/bs.vh.2018.01.015DOI Listing
November 2018

Pharmacological effects of nanoencapsulation of human-based dosing of probucol on ratio of secondary to primary bile acids in gut, during induction and progression of type 1 diabetes.

Artif Cells Nanomed Biotechnol 2018 13;46(sup3):S748-S754. Epub 2018 Nov 13.

a Biotechnology and Drug Development Research Laboratory, School of Pharmacy and Biomedical Sciences , Curtin Health Innovation Research Institute, Curtin University , Perth , Australia.

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https://www.tandfonline.com/doi/full/10.1080/21691401.2018.1
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http://dx.doi.org/10.1080/21691401.2018.1511572DOI Listing
November 2018

Eudragit-based microcapsules of probucol with a gut-bacterial processed secondary bile acid.

Ther Deliv 2018 Nov;9(11):811-821

Biotechnology & Drug Development Research Laboratory, School of Pharmacy & Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth, Western Australia, Australia.

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https://www.future-science.com/doi/10.4155/tde-2018-0036
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http://dx.doi.org/10.4155/tde-2018-0036DOI Listing
November 2018

Morphological, Stability, and Hypoglycemic Effects of New Gliclazide-Bile Acid Microcapsules for Type 1 Diabetes Treatment: the Microencapsulation of Anti-diabetics Using a Microcapsule-Stabilizing Bile Acid.

AAPS PharmSciTech 2018 Oct 30;19(7):3009-3018. Epub 2018 Jul 30.

School of Pharmacy, Curtin University, GPO Box U1987, Perth, WA, 6845, Australia.

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http://dx.doi.org/10.1208/s12249-018-1127-8DOI Listing
October 2018

Molecular Targets Modulated by Fangchinoline in Tumor Cells and Preclinical Models.

Molecules 2018 Oct 5;23(10). Epub 2018 Oct 5.

College of Korean Medicine, Kyung Hee University, 24 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea.

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http://dx.doi.org/10.3390/molecules23102538DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222742PMC
October 2018

Potential Anti-Inflammatory and Anti-Cancer Properties of Farnesol.

Molecules 2018 Oct 31;23(11). Epub 2018 Oct 31.

Department of Science in Korean Medicine, Kyung Hee University, 24 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea.

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http://www.mdpi.com/1420-3049/23/11/2827
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http://dx.doi.org/10.3390/molecules23112827DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278318PMC
October 2018

Formononetin-induced oxidative stress abrogates the activation of STAT3/5 signaling axis and suppresses the tumor growth in multiple myeloma preclinical model.

Cancer Lett 2018 Sep 29;431:123-141. Epub 2018 May 29.

College of Korean Medicine, Kyung Hee University, 24 Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2018.05.038DOI Listing
September 2018

Novel tumor necrosis factor-α induced protein eight (TNFAIP8/TIPE) family: Functions and downstream targets involved in cancer progression.

Cancer Lett 2018 Sep 18;432:260-271. Epub 2018 Jun 18.

Cancer Biology Laboratory & DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB), Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam, 781039, India. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2018.06.017DOI Listing
September 2018

The Role of Signal Transducer and Activator of Transcription 3 (STAT3) and Its Targeted Inhibition in Hematological Malignancies.

Cancers (Basel) 2018 Sep 13;10(9). Epub 2018 Sep 13.

Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore.

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http://www.mdpi.com/2072-6694/10/9/327
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http://dx.doi.org/10.3390/cancers10090327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162647PMC
September 2018

Novel nano-encapsulation of probucol in microgels: scanning electron micrograph characterizations, buoyancy profiling, and antioxidant assay analyses.

Artif Cells Nanomed Biotechnol 2018 27;46(sup3):S741-S747. Epub 2018 Sep 27.

a Biotechnology and Drug Development Research Laboratory, School of Pharmacy and Biomedical Sciences, Curtin Health Innovation Research Institute , Curtin University , Perth , Australia.

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https://www.tandfonline.com/doi/full/10.1080/21691401.2018.1
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http://dx.doi.org/10.1080/21691401.2018.1511571DOI Listing
September 2018

TIPE Family of Proteins and Its Implications in Different Chronic Diseases.

Int J Mol Sci 2018 Sep 29;19(10). Epub 2018 Sep 29.

Cancer Biology Laboratory, DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB), Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Assam 781039, India.

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http://www.mdpi.com/1422-0067/19/10/2974
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http://dx.doi.org/10.3390/ijms19102974DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213092PMC
September 2018

Role of RNF20 in cancer development and progression - a comprehensive review.

Biosci Rep 2018 08 12;38(4). Epub 2018 Jul 12.

Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, 117600 Singapore

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http://dx.doi.org/10.1042/BSR20171287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043722PMC
August 2018

The effect of ovarian reserve and receptor signalling on granulosa cell apoptosis during human follicle development.

Mol Cell Endocrinol 2018 07 4;470:219-227. Epub 2017 Nov 4.

Stem Cell and Cancer Biology Laboratory, School of Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth, Australia.

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http://dx.doi.org/10.1016/j.mce.2017.11.002DOI Listing
July 2018

Possible use of Punica granatum (Pomegranate) in cancer therapy.

Pharmacol Res 2018 07 2;133:53-64. Epub 2018 May 2.

Cancer Biology Laboratory & DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB), Department of Biosciences & Bioengineering, Indian Institute of Technology Guwahati, Assam 781039, India. Electronic address:

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http://dx.doi.org/10.1016/j.phrs.2018.04.021DOI Listing
July 2018

Potential role of genipin in cancer therapy.

Pharmacol Res 2018 07 24;133:195-200. Epub 2018 May 24.

Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, 117600, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.phrs.2018.05.007DOI Listing
July 2018

Antioxidant response elements: Discovery, classes, regulation and potential applications.

Redox Biol 2018 07 7;17:297-314. Epub 2018 May 7.

Molecular Toxicology Laboratory, Department of Biotechnology, Bharathiar University, Coimbatore 641046, Tamilnadu, India. Electronic address:

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http://dx.doi.org/10.1016/j.redox.2018.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007815PMC
July 2018

Modulation of diverse oncogenic transcription factors by thymoquinone, an essential oil compound isolated from the seeds of Nigella sativa Linn.

Pharmacol Res 2018 07 21;133:213-214. Epub 2018 May 21.

Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore; School of Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth, WA 6009, Australia. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10436618183066
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http://dx.doi.org/10.1016/j.phrs.2018.05.004DOI Listing
July 2018

NGAL is Downregulated in Oral Squamous Cell Carcinoma and Leads to Increased Survival, Proliferation, Migration and Chemoresistance.

Cancers (Basel) 2018 Jul 10;10(7). Epub 2018 Jul 10.

Cancer Biology Laboratory & DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB), Department of Biosciences & Bioengineering, Indian Institute of Technology Guwahati, Assam 781039, India.

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http://dx.doi.org/10.3390/cancers10070228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071146PMC
July 2018

Evidence for the Involvement of the Master Transcription Factor NF-κB in Cancer Initiation and Progression.

Biomedicines 2018 Jul 27;6(3). Epub 2018 Jul 27.

Institute of Molecular and Cellular Biology (A*STAR), 61 Biopolis Drive, Singapore 138673, Singapore.

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http://dx.doi.org/10.3390/biomedicines6030082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163404PMC
July 2018

Delivery of expression constructs of secreted frizzled-related protein 4 and its domains by chitosan-dextran sulfate nanoparticles enhances their expression and anti-cancer effects.

Mol Cell Biochem 2018 Jun 28;443(1-2):205-213. Epub 2017 Nov 28.

Stem Cell and Cancer Biology Laboratory, School of Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, GPO Box U1987, Perth, WA, 6845, Australia.

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http://link.springer.com/10.1007/s11010-017-3225-4
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http://dx.doi.org/10.1007/s11010-017-3225-4DOI Listing
June 2018

The Influence of Breast Tumour-Derived Factors and Wnt Antagonism on the Transformation of Adipose-Derived Mesenchymal Stem Cells into Tumour-Associated Fibroblasts.

Cancer Microenviron 2018 Jun 10;11(1):71-84. Epub 2018 Apr 10.

Stem Cell and Cancer Biology Laboratory, School of Pharmacy and Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth, WA, 6102, Australia.

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http://dx.doi.org/10.1007/s12307-018-0210-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008265PMC
June 2018

Potential Role of Natural Compounds as Anti-Angiogenic Agents in Cancer.

Curr Vasc Pharmacol 2017 ;15(6):503-519

Stem Cell and Cancer Biology Laboratory, School of Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth, WA 6009. Australia.

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http://www.eurekaselect.com/154180/article
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http://dx.doi.org/10.2174/1570161115666170713094319DOI Listing
May 2018

Molecular targets and anti-cancer potential of escin.

Cancer Lett 2018 05 21;422:1-8. Epub 2018 Feb 21.

Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, 117593, Singapore. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03043835183016
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http://dx.doi.org/10.1016/j.canlet.2018.02.027DOI Listing
May 2018

Pro-Apoptotic and Anti-Cancer Properties of Diosgenin: A Comprehensive and Critical Review.

Nutrients 2018 05 19;10(5). Epub 2018 May 19.

Department of Pharmaceutical Sciences, College of Pharmacy, Larkin University, 18301 N. Miami Avenue, Miami, FL 33169, USA.

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http://dx.doi.org/10.3390/nu10050645DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986524PMC
May 2018

Corrigendum on "Isorhamnetin augments the anti-tumor effect of capeciatbine through the negative regulation of NF-κB signaling cascade in gastric cancer" [Cancer Lett. 363 (1) (2015) 28-36].

Cancer Lett 2018 04 17;420:259. Epub 2018 Jan 17.

Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, 117597, Singapore; Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia; Curtin Health Innovation Research Institute, Biosciences Research Precinct, School of Biomedical Sciences, Faculty of Health Sciences, Curtin University, Perth, WA 6845, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2018.01.003DOI Listing
April 2018

Correction: Role of novel histone modifications in cancer.

Oncotarget 2018 Apr 10;9(27):19460. Epub 2018 Apr 10.

Institute of Molecular and Cell Biology, ASTAR, Biopolis Drive, Proteos, Singapore, Singapore.

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http://dx.doi.org/10.18632/oncotarget.25152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5922411PMC
April 2018

Modulation of diverse oncogenic transcription factors by thymoquinone, an essential oil compound isolated from the seeds of Nigella sativa Linn.

Pharmacol Res 2018 03 21;129:357-364. Epub 2017 Nov 21.

Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, 117600, Singapore; School of Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth, Western Australia 6009, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.phrs.2017.11.023DOI Listing
March 2018

Therapeutic potential of gambogic acid, a caged xanthone, to target cancer.

Cancer Lett 2018 03 13;416:75-86. Epub 2017 Dec 13.

Cancer Biology Laboratory, DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB), Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Assam, 781039, India. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2017.12.014DOI Listing
March 2018

Dual role of autophagy in hallmarks of cancer.

Oncogene 2018 03 19;37(9):1142-1158. Epub 2017 Dec 19.

Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.

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http://dx.doi.org/10.1038/s41388-017-0046-6DOI Listing
March 2018

Granulosa Cell Apoptosis in the Ovarian Follicle-A Changing View.

Front Endocrinol (Lausanne) 2018 2;9:61. Epub 2018 Mar 2.

Stem Cell and Cancer Biology Laboratory, School of Pharmacy and Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth, WA, Australia.

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http://dx.doi.org/10.3389/fendo.2018.00061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840209PMC
March 2018

The inhibitory influence of adipose tissue-derived mesenchymal stem cell environment and Wnt antagonism on breast tumour cell lines.

Int J Biochem Cell Biol 2018 02 19;95:63-72. Epub 2017 Dec 19.

Stem Cell and Cancer Biology Laboratory, School of Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Western Australia, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.biocel.2017.12.013DOI Listing
February 2018

Role of novel histone modifications in cancer.

Oncotarget 2018 Feb 17;9(13):11414-11426. Epub 2017 Dec 17.

Institute of Molecular and Cell Biology, ASTAR, Biopolis Drive, Proteos, Singapore, Singapore.

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http://dx.doi.org/10.18632/oncotarget.23356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834259PMC
February 2018

Triple negative breast cancer in Asia: An insider's view.

Cancer Treat Rev 2018 Jan 10;62:29-38. Epub 2017 Nov 10.

Cancer Science Institute of Singapore, National University of Singapore, Singapore; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; National University Cancer Institute, National University Health System, Singapore; Curtin Medical School, Faculty of Health Sciences, Curtin University, Perth, WA, Australia; Medical Science Cluster, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.ctrv.2017.10.014DOI Listing
January 2018

Regulation of Cancer Stem Cell Metabolism by Secreted Frizzled-Related Protein 4 (sFRP4).

Cancers (Basel) 2018 Jan 31;10(2). Epub 2018 Jan 31.

School of Pharmacy and Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth, WA 6102, Australia.

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http://dx.doi.org/10.3390/cancers10020040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836072PMC
January 2018

The Role of Resveratrol in Cancer Therapy.

Int J Mol Sci 2017 Dec 1;18(12). Epub 2017 Dec 1.

College of Korean Medicine, Kyung Hee University, 24 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea.

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http://dx.doi.org/10.3390/ijms18122589DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751192PMC
December 2017

The Role of Wnt Signalling in Angiogenesis.

Clin Biochem Rev 2017 Nov;38(3):131-142

Stem Cell and Cancer Biology Laboratory, School of Biomedical Sciences, Curtin Health Innovation Research Institute, Bentley, WA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5759160PMC
November 2017

Increased Indoleamine 2,3-Dioxygenase and Quinolinic Acid Expression in Microglia and Müller Cells of Diabetic Human and Rodent Retina.

Invest Ophthalmol Vis Sci 2017 10;58(12):5043-5055

Department of Ophthalmology, the Eugene and Marilyn Glick Eye Institute, Indiana University, Indianapolis, Indiana, United States.

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http://dx.doi.org/10.1167/iovs.17-21654DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5633007PMC
October 2017

Role of epigenetic modulation in cancer stem cell fate.

Int J Biochem Cell Biol 2017 09 12;90:9-16. Epub 2017 Jul 12.

Stem Cell and Cancer Biology Laboratory, School of Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth, WA, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.biocel.2017.07.003DOI Listing
September 2017

Epigenetic reprogramming converts human Wharton's jelly mesenchymal stem cells into functional cardiomyocytes by differential regulation of Wnt mediators.

Stem Cell Res Ther 2017 08 14;8(1):185. Epub 2017 Aug 14.

Division of Cancer Stem Cells and Cardiovascular Regeneration, Manipal Institute of Regenerative Medicine, Manipal University, Bangalore, 560 065, India.

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http://dx.doi.org/10.1186/s13287-017-0638-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557557PMC
August 2017

Infertility and ovarian follicle reserve depletion are associated with dysregulation of the FSH and LH receptor density in human antral follicles.

Mol Cell Endocrinol 2017 05 7;446:40-51. Epub 2017 Feb 7.

School of Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth, Australia.

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May 2017

Targeting multiple oncogenic pathways for the treatment of hepatocellular carcinoma.

Target Oncol 2017 02;12(1):1-10

Department of Pharmaceutical Sciences, College of Pharmacy, Larkin Health Sciences Institute, 18301 N. Miami Avenue, Miami, FL, 33169, USA.

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http://dx.doi.org/10.1007/s11523-016-0452-7DOI Listing
February 2017

Butein in health and disease: A comprehensive review.

Phytomedicine 2017 Feb 12;25:118-127. Epub 2016 Dec 12.

Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology, Guwahati, Assam 781 039, India. Electronic address:

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http://dx.doi.org/10.1016/j.phymed.2016.12.002DOI Listing
February 2017

Wanted DEAD/H or Alive: Helicases Winding Up in Cancers.

J Natl Cancer Inst 2017 01 25;109(6). Epub 2017 Jan 25.

Affiliations of authors: Cancer Science Institute of Singapore, National University of Singapore, Singapore (WC, GR, SSS, CW, YY, TZT, HY, BCG, TB, APK); Departments of Pharmacology (WC, GR, SSS, CW, BCG, GS, APK), Physiology (ZXC, ZC, CTY), and Biochemistry (VT), Yong Loo Lin School of Medicine, National University of Singapore, Singapore; KK Women's and Children's Hospital, Singapore (ZXC); Stem Cell and Cancer Biology Laboratory (FA), School of Biomedical Sciences (GS, APK), Curtin Health Innovation Research Institute, Curtin Medical School (APK), Curtin University, Perth, WA, Australia; National University Cancer Institute, National University Health System, Singapore (CTY, BCG, APK); 2 Department of Pediatrics, Semmelweis University, Budapest, Hungary (LSP); MTA TTK Lendület Cancer Biomarker Research Group, Research Centre for Natural Sciences, Budapest, Hungary (LSP); Department of Renal Medicine (MBL) and Department of Haematology-Oncology (BCG), National University Health System, Singapore; Institute of Molecular and Cell Biology (IMCB), A*STAR (Agency for Science, Technology and Research), Singapore (VT); Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, Australia (VT); Department of Biological Sciences, University of North Texas, Denton, TX (APK).

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http://dx.doi.org/10.1093/jnci/djw278DOI Listing
January 2017

Advanced bile acid-based multi-compartmental microencapsulated pancreatic β-cells integrating a polyelectrolyte-bile acid formulation, for diabetes treatment.

Artif Cells Nanomed Biotechnol 2016 30;44(2):588-95. Epub 2014 Oct 30.

a Biotechnology and Drug Development Research Laboratory, School of Pharmacy, Curtin Health Innovation Research Institute, Biosciences Research Precinct, Curtin University , Perth , Western Australia , Australia.

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http://dx.doi.org/10.3109/21691401.2014.971806DOI Listing
November 2016

Multicompartmental, multilayered probucol microcapsules for diabetes mellitus: Formulation characterization and effects on production of insulin and inflammation in a pancreatic β-cell line.

Artif Cells Nanomed Biotechnol 2016 Nov 17;44(7):1642-53. Epub 2015 Sep 17.

a Biotechnology and Drug Development Research Laboratory, School of Pharmacy, Curtin Health Innovation Research Institute, Curtin University , Perth, Western Australia, Australia.

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http://dx.doi.org/10.3109/21691401.2015.1069299DOI Listing
November 2016

Cancer stem cell metabolism: a potential target for cancer therapy.

Mol Cancer 2016 11 8;15(1):69. Epub 2016 Nov 8.

Stem Cell and Cancer Biology Laboratory, School of Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth, WA, 6102, Australia.

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http://dx.doi.org/10.1186/s12943-016-0555-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101698PMC
November 2016

Characterization of a novel bile acid-based delivery platform for microencapsulated pancreatic β-cells.

Artif Cells Nanomed Biotechnol 2016 11;44(1):194-200. Epub 2014 Jul 11.

a Biotechnology and Drug Development Research Laboratory, School of Pharmacy, CHIRI Biosciences Research Precinct, Curtin University , Perth , WA , Australia.

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http://dx.doi.org/10.3109/21691401.2014.934457DOI Listing
October 2016

A comprehensive study of novel microcapsules incorporating gliclazide and a permeation enhancing bile acid: hypoglycemic effect in an animal model of Type-1 diabetes.

Drug Deliv 2016 Oct 26;23(8):2869-2880. Epub 2015 Nov 26.

a Biotechnology and Drug Development Research Laboratory, School of Pharmacy, Curtin Health Innovation Research Institute, Biosciences Research Precinct, School of Pharmacy, Curtin University , Perth , WA , Australia.

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http://dx.doi.org/10.3109/10717544.2015.1110846DOI Listing
October 2016

Cancer prevention and therapy through the modulation of transcription factors by bioactive natural compounds.

Semin Cancer Biol 2016 10 30;40-41:35-47. Epub 2016 Mar 30.

Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore; School of Biomedical Sciences, Curtin Health Innovation Research Institute, Biosciences Research Precinct, Curtin University, Western Australia 6009, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.semcancer.2016.03.005DOI Listing
October 2016

The role of the bile acid chenodeoxycholic acid in the targeted oral delivery of the anti-diabetic drug gliclazide, and its applications in type 1 diabetes.

Artif Cells Nanomed Biotechnol 2016 Sep 25;44(6):1508-19. Epub 2015 Jul 25.

a Biotechnology and Drug Development Research Laboratory, School of Pharmacy, Curtin Health Innovation Research Institute, Biosciences Research Precinct, School of Pharmacy, Curtin University , Perth WA , Australia.

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http://dx.doi.org/10.3109/21691401.2015.1058807DOI Listing
September 2016

Swelling, mechanical strength, and release properties of probucol microcapsules with and without a bile acid, and their potential oral delivery in diabetes.

Artif Cells Nanomed Biotechnol 2016 Aug 26;44(5):1290-7. Epub 2015 Mar 26.

a Biotechnology and Drug Development Research Laboratory, School of Pharmacy, Curtin Health Innovation Research Institute, Biosciences Research Precinct, Curtin University , Perth , Western Australia , Australia.

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http://dx.doi.org/10.3109/21691401.2015.1024845DOI Listing
August 2016

Novel chenodeoxycholic acid-sodium alginate matrix in the microencapsulation of the potential antidiabetic drug, probucol. An in vitro study.

J Microencapsul 2015 20;32(6):589-97. Epub 2015 Jul 20.

a Biotechnology and Drug Development Research Laboratory, School of Pharmacy, Curtin Health Innovation Research Institute, Curtin University , Perth, Western Australia , Australia .

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http://dx.doi.org/10.3109/02652048.2015.1065922DOI Listing
June 2016

Targeting transcription factor STAT3 for cancer prevention and therapy.

Pharmacol Ther 2016 06 12;162:86-97. Epub 2016 Feb 12.

Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; School of Biomedical Sciences, CHIRI Biosciences Research Precinct, Curtin University, WA 6009, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.pharmthera.2015.10.004DOI Listing
June 2016

sFRP-mediated Wnt sequestration as a potential therapeutic target for Alzheimer's disease.

Int J Biochem Cell Biol 2016 06 7;75:104-11. Epub 2016 Apr 7.

Stem Cell and Cancer Biology Laboratory, School of Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth, Western Australia 6845, Australia.

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http://dx.doi.org/10.1016/j.biocel.2016.04.002DOI Listing
June 2016

Role of Wnt signalling in early pregnancy.

Reprod Fertil Dev 2016 Apr;28(5):525-44

School of Women's and Infant's Health, University of Western Australia, King Edward Memorial Hospital, 374 Bagot Road, Subiaco, WA 6008, Australia.

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http://dx.doi.org/10.1071/RD14079DOI Listing
April 2016

Dysregulation of granulosal bone morphogenetic protein receptor 1B density is associated with reduced ovarian reserve and the age-related decline in human fertility.

Mol Cell Endocrinol 2016 Apr 20;425:84-93. Epub 2016 Jan 20.

School of Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth, Australia.

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http://dx.doi.org/10.1016/j.mce.2016.01.016DOI Listing
April 2016

Release and swelling studies of an innovative antidiabetic-bile acid microencapsulated formulation, as a novel targeted therapy for diabetes treatment.

J Microencapsul 2015 29;32(2):151-6. Epub 2014 Sep 29.

Biotechnology and Drug Development Research Laboratory, School of Pharmacy, Curtin Health Innovation Research Institute, Biosciences Research Precinct, Curtin University , Perth, Western Australia , Australia .

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http://dx.doi.org/10.3109/02652048.2014.958204DOI Listing
March 2016

Secreted frizzled-related protein 4 inhibits glioma stem-like cells by reversing epithelial to mesenchymal transition, inducing apoptosis and decreasing cancer stem cell properties.

PLoS One 2015 1;10(6):e0127517. Epub 2015 Jun 1.

Division of Cancer Stem Cells and Cardiovascular Regeneration, Manipal Institute of Regenerative Medicine, Manipal University, Bangalore, 560 065, India; Stem Cell and Cancer Biology Laboratory, School of Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth, 6845, Western Australia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452329PMC
March 2016

Therapeutic approach to target mesothelioma cancer cells using the Wnt antagonist, secreted frizzled-related protein 4: Metabolic state of cancer cells.

Exp Cell Res 2016 Feb 8;341(2):218-24. Epub 2016 Feb 8.

Stem Cell and Cancer Biology Laboratory, School of Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Bentley, WA, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.yexcr.2016.02.008DOI Listing
February 2016

Wnt antagonist secreted frizzled-related protein 4 upregulates adipogenic differentiation in human adipose tissue-derived mesenchymal stem cells.

PLoS One 2015 25;10(2):e0118005. Epub 2015 Feb 25.

School of Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth, Western Australia, Australia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340908PMC
January 2016

Ageing and the telomere connection: An intimate relationship with inflammation.

Ageing Res Rev 2016 Jan 23;25:55-69. Epub 2015 Nov 23.

Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Curtin Health Innovation Research Institute, Biosciences Research Precinct, School of Biomedical Sciences, Faculty of Health Sciences, Curtin University, WA, Australia; Memory, Aging and Cognition Centre, National University Health System, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.arr.2015.11.006DOI Listing
January 2016

Multi-lineage differentiation of mesenchymal stem cells - To Wnt, or not Wnt.

Int J Biochem Cell Biol 2015 Nov 26;68:139-47. Epub 2015 Sep 26.

Stem Cell and Cancer Biology Laboratory, School of Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth, Western Australia 6102, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.biocel.2015.09.008DOI Listing
November 2015

Targeting the PI3K/Akt signaling pathway in gastric carcinoma: A reality for personalized medicine?

World J Gastroenterol 2015 Nov;21(43):12261-73

Shikha Satendra Singh, Wei Ney Yap, Shreya Kar, Chao Wang, Wanpei Cai, Gautam Sethi, Alan Prem Kumar, Cancer Science Institute of Singapore, National University of Singapore, Singapore City 117597, Singapore.

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http://dx.doi.org/10.3748/wjg.v21.i43.12261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649111PMC
November 2015

The effect of a tertiary bile acid, taurocholic acid, on the morphology and physical characteristics of microencapsulated probucol: potential applications in diabetes: a characterization study.

Drug Deliv Transl Res 2015 Oct;5(5):511-22

Biotechnology and Drug Development Research Laboratory, School of Pharmacy, Curtin Health Innovation Research Institute, Biosciences Research Precinct, Curtin University, GPO Box U1987, Perth, Western Australia, 6845, Australia.

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October 2015

Author Response: Sufficient Evidence for Lymphatics in the Developing and Adult Human Choroid?

Invest Ophthalmol Vis Sci 2015 Oct;56(11):6711-3

School of Optometry, University of New South Wales, Sydney, New South Wales, Australia; and 5Save Sight Institute, University of Sydney, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1167/iovs.15-18011DOI Listing
October 2015

Flow cytometric analysis of FSHR, BMRR1B, LHR and apoptosis in granulosa cells and ovulation rate in merino sheep.

Reproduction 2015 Aug 6;150(2):151-63. Epub 2015 May 6.

School of Biomedical SciencesCurtin Health Innovation Research Institute, Curtin University, GPO Box U1987, Perth, Western Australia 6845, AustraliaCentre of Bioactive Discovery in Health and AgeingUniversity of New England, Armidale, New South Wales, Australia.

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http://dx.doi.org/10.1530/REP-14-0581DOI Listing
August 2015

Microencapsulation as a novel delivery method for the potential antidiabetic drug, Probucol.

Drug Des Devel Ther 2014 9;8:1221-30. Epub 2014 Sep 9.

Biotechnology and Drug Development Research Laboratory School of Pharmacy, Curtin Health Innovation Research Institute, Biosciences Research Precinct, Curtin University, Perth, Western Australia, Australia.

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http://dx.doi.org/10.2147/DDDT.S67349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166910PMC
July 2015

An optimized probucol microencapsulated formulation integrating a secondary bile acid (deoxycholic acid) as a permeation enhancer.

Drug Des Devel Ther 2014 29;8:1673-83. Epub 2014 Sep 29.

Biotechnology and Drug Development Research Laboratory, School of Pharmacy, Curtin Health Innovation Research Institute, Biosciences Research Precinct, Curtin University, Perth, Australia.

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http://dx.doi.org/10.2147/DDDT.S68247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4189710PMC
July 2015

Isorhamnetin augments the anti-tumor effect of capecitabine through the negative regulation of NF-κB signaling cascade in gastric cancer.

Cancer Lett 2015 07 28;363(1):28-36. Epub 2015 Mar 28.

Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597; Department of Botany and Microbiology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia; Curtin Health Innovation Research Institute, Biosciences Research Precinct, School of Biomedical Sciences, Faculty of Health Sciences, Curtin University, Perth, WA 6845, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2015.03.033DOI Listing
July 2015

Targeting TNF-related apoptosis-inducing ligand (TRAIL) receptor by natural products as a potential therapeutic approach for cancer therapy.

Exp Biol Med (Maywood) 2015 Jun 7;240(6):760-73. Epub 2015 Apr 7.

Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore School of Biomedical Sciences, CHIRI Biosciences Research Precinct, Curtin University, Western Australia 6009, Australia Department of Botany and Microbiology, College of Science, King Saud University, Riyadh 11451, Kingdom of Saudi Arabia

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http://dx.doi.org/10.1177/1535370215579167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4935211PMC
June 2015

Novel artificial cell microencapsulation of a complex gliclazide-deoxycholic bile acid formulation: a characterization study.

Drug Des Devel Ther 2014 28;8:1003-12. Epub 2014 Jul 28.

Biotechnology and Drug Development Research Laboratory, School of Pharmacy, Curtin Health Innovation Research Institute, Biosciences Research Precinct, Curtin University, Perth, WA, Australia.

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http://dx.doi.org/10.2147/DDDT.S65396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122185PMC
May 2015

NF-κB in cancer therapy.

Arch Toxicol 2015 May 18;89(5):711-31. Epub 2015 Feb 18.

Department of Pharmacology, Yong Loo Lin School of Medicine, Cancer Science Institute, National University of Singapore, Singapore, 117597, Singapore.

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http://dx.doi.org/10.1007/s00204-015-1470-4DOI Listing
May 2015

Analysis of the intricate relationship between chronic inflammation and cancer.

Biochem J 2015 May;468(1):1-15

*Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.

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http://dx.doi.org/10.1042/BJ20141337DOI Listing
May 2015

Probucol release from novel multicompartmental microcapsules for the oral targeted delivery in type 2 diabetes.

AAPS PharmSciTech 2015 Feb 29;16(1):45-52. Epub 2014 Aug 29.

Biotechnology and Drug Development Research Laboratory, School of Pharmacy, Curtin Health Innovation Research Institute, Biosciences Research Precinct, Curtin University, Perth, WA, Australia.

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http://dx.doi.org/10.1208/s12249-014-0205-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309805PMC
February 2015

The multifaceted role of curcumin in cancer prevention and treatment.

Molecules 2015 Feb 5;20(2):2728-69. Epub 2015 Feb 5.

Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.

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http://dx.doi.org/10.3390/molecules20022728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272781PMC
February 2015

Secreted frizzled-related protein 4 and its implications in cancer and apoptosis.

Tumour Biol 2015 Jan 13;36(1):143-52. Epub 2014 Dec 13.

School of Biomedical Science, Faculty of Health Sciences, Curtin University, GPO Box U1987, Perth, Western Australia, 6845, Australia,

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http://dx.doi.org/10.1007/s13277-014-2956-zDOI Listing
January 2015

Evidence for lymphatics in the developing and adult human choroid.

Invest Ophthalmol Vis Sci 2015 Jan 13;56(2):1310-27. Epub 2015 Jan 13.

Discipline of Anatomy, School of Medical Sciences, Bosch Institute, The University of Sydney, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1167/iovs.14-15705DOI Listing
January 2015

Multifunctional properties of chicken embryonic prenatal mesenchymal stem cells- pluripotency, plasticity, and tumor suppression.

Stem Cell Rev 2014 Dec;10(6):856-70

Division of Cancer Stem Cells and Cardiovascular Regeneration, Manipal Institute of Regenerative Medicine, Manipal University, Bangalore, 560 065, India.

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http://dx.doi.org/10.1007/s12015-014-9530-3DOI Listing
December 2014

The effects of phenoxodiol on the cell cycle of prostate cancer cell lines.

Cancer Cell Int 2014 8;14(1):110. Epub 2014 Nov 8.

School of Anatomy, Physiology and Human Biology, Faculty of Science, The University of Western Australia, Crawley, Perth, WA 6009 Australia ; Curtin Health Innovation Research Institute, Biosciences Research Precinct, School of Biomedical Sciences, Faculty of Health Sciences, Curtin University, GPO Box U1987, 6845 Perth, WA Australia.

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http://dx.doi.org/10.1186/s12935-014-0110-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231195PMC
November 2014

Nutrient regulation of insulin secretion and action.

J Endocrinol 2014 Jun 25;221(3):R105-20. Epub 2014 Mar 25.

School of Biomedical SciencesCHIRI Biosciences Research Precinct, Curtin University, GPO Box U1987, Perth, Western Australia, Australia.

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http://dx.doi.org/10.1530/JOE-13-0616DOI Listing
June 2014