Frank A J L Scheer

Frank A J L Scheer

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Frank A J L Scheer

Publications by authors named "Frank A J L Scheer"

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Sex-dependent link between circadian misalignment and adiposity.

Nat Rev Endocrinol 2020 Jan;16(1):13-15

Medical Chronobiology Program, Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41574-019-0293-4DOI Listing
January 2020

Melatonin Effects on Glucose Metabolism: Time To Unlock the Controversy.

Trends Endocrinol Metab 2020 Jan 1. Epub 2020 Jan 1.

Medical Chronobiology Program, Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tem.2019.11.011DOI Listing
January 2020

Impact of circadian disruption on glucose metabolism: implications for type 2 diabetes.

Diabetologia 2020 Jan 8. Epub 2020 Jan 8.

Brigham and Women's Hospital, Medical Chronobiology Program, Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, 221 Longwood Avenue, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1007/s00125-019-05059-6DOI Listing
January 2020

Health consequences of circadian disruption.

Sleep 2020 Jan;43(1)

Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA.

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http://dx.doi.org/10.1093/sleep/zsz194DOI Listing
January 2020

Sex differences in the circadian misalignment effects on energy regulation.

Proc Natl Acad Sci U S A 2019 Nov 4;116(47):23806-23812. Epub 2019 Nov 4.

Medical Chronobiology Program, Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA 02115;

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http://dx.doi.org/10.1073/pnas.1914003116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6876189PMC
November 2019

Impact of Circadian Disruption on Cardiovascular Function and Disease.

Trends Endocrinol Metab 2019 Oct 16;30(10):767-779. Epub 2019 Aug 16.

Medical Chronobiology Program, Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA 02115, USA; Division of Sleep Medicine, Department of Medicine, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10432760193013
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http://dx.doi.org/10.1016/j.tem.2019.07.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779516PMC
October 2019

The circadian system modulates the rate of recovery of systolic blood pressure after exercise in humans.

Sleep 2019 Oct 16. Epub 2019 Oct 16.

Oregon Institute of Occupational Health Sciences, Oregon Health and Science University, Portland, Oregon, USA.

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http://dx.doi.org/10.1093/sleep/zsz253DOI Listing
October 2019

Meal timing and obesity: interactions with macronutrient intake and chronotype.

Int J Obes (Lond) 2019 09 31;43(9):1701-1711. Epub 2019 Jan 31.

Medical Chronobiology Program, Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA, USA.

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http://www.nature.com/articles/s41366-018-0284-x
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http://dx.doi.org/10.1038/s41366-018-0284-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669101PMC
September 2019

Ghrelin is impacted by the endogenous circadian system and by circadian misalignment in humans.

Int J Obes (Lond) 2019 08 19;43(8):1644-1649. Epub 2018 Sep 19.

Medical Chronobiology Program, Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA, USA.

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http://www.nature.com/articles/s41366-018-0208-9
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http://dx.doi.org/10.1038/s41366-018-0208-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424662PMC
August 2019

Impact of mental stress, the circadian system and their interaction on human cardiovascular function.

Psychoneuroendocrinology 2019 05 16;103:125-129. Epub 2019 Jan 16.

Medical Chronobiology Program, Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, 02215, United States; Division of Sleep Medicine, Harvard Medical School, Boston, MA, 02215, United States; Oregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, OR, 97239, United States.

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http://dx.doi.org/10.1016/j.psyneuen.2019.01.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686856PMC
May 2019

Heritability of the timing of food intake.

Clin Nutr 2019 04 12;38(2):767-773. Epub 2018 Mar 12.

Murcia Institute for BioHealth Research (IMIB-Arrixaca-UM), University of Murcia, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.clnu.2018.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135708PMC
April 2019

A healthy lifestyle - reducing T2DM risk in shift workers?

Nat Rev Endocrinol 2019 04;15(4):194-196

Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41574-019-0164-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642058PMC
April 2019

Caloric and Macronutrient Intake Differ with Circadian Phase and between Lean and Overweight Young Adults.

Nutrients 2019 03 11;11(3). Epub 2019 Mar 11.

Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, 221 Longwood Ave, Boston, MA 02115, USA.

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https://www.mdpi.com/2072-6643/11/3/587
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http://dx.doi.org/10.3390/nu11030587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471585PMC
March 2019

Circadian clocks and insulin resistance.

Nat Rev Endocrinol 2019 02;15(2):75-89

Department of Endocrinology and Metabolism, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands.

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http://www.nature.com/articles/s41574-018-0122-1
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http://dx.doi.org/10.1038/s41574-018-0122-1DOI Listing
February 2019

Effects of circadian misalignment on cognition in chronic shift workers.

Sci Rep 2019 Jan 24;9(1):699. Epub 2019 Jan 24.

Medical Chronobiology Program, Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1038/s41598-018-36762-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346005PMC
January 2019

Differential effects of the circadian system and circadian misalignment on insulin sensitivity and insulin secretion in humans.

Diabetes Obes Metab 2018 10 2;20(10):2481-2485. Epub 2018 Jul 2.

Medical Chronobiology Program, Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1111/dom.13391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167165PMC
October 2018

Fractal regulation and incident Alzheimer's disease in elderly individuals.

Alzheimers Dement 2018 09 4;14(9):1114-1125. Epub 2018 May 4.

Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA, USA; Division of Sleep Medicine, Department of Medicine, Harvard Medical School, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2018.03.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201319PMC
September 2018

Circadian misalignment induces fatty acid metabolism gene profiles and compromises insulin sensitivity in human skeletal muscle.

Proc Natl Acad Sci U S A 2018 07 9;115(30):7789-7794. Epub 2018 Jul 9.

Department of Nutrition and Movement Sciences, School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, 6200 MD Maastricht, The Netherlands;

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http://dx.doi.org/10.1073/pnas.1722295115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6065021PMC
July 2018

Daily circadian misalignment impairs human cognitive performance task-dependently.

Sci Rep 2018 02 14;8(1):3041. Epub 2018 Feb 14.

Medical Chronobiology Program, Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA, 02115, United States.

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http://dx.doi.org/10.1038/s41598-018-20707-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5812992PMC
February 2018

Circadian Biology: Uncoupling Human Body Clocks by Food Timing.

Curr Biol 2017 07;27(13):R656-R658

Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Medical Chronobiology Program, Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.cub.2017.05.057DOI Listing
July 2017

Circadian Misalignment Increases C-Reactive Protein and Blood Pressure in Chronic Shift Workers.

J Biol Rhythms 2017 04 27;32(2):154-164. Epub 2017 Mar 27.

Medical Chronobiology Program, Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1177/0748730417697537DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5858578PMC
April 2017

Circadian gene variants influence sleep and the sleep electroencephalogram in humans.

Chronobiol Int 2016;33(5):561-73. Epub 2016 Apr 18.

a Division of Sleep and Circadian Disorders, Department of Medicine and Department of Neurology , Brigham and Women's Hospital , Boston , MA , USA.

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http://dx.doi.org/10.3109/07420528.2016.1167078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5267557PMC
March 2017

Human adipose tissue expresses intrinsic circadian rhythm in insulin sensitivity.

FASEB J 2016 09 2;30(9):3117-23. Epub 2016 Jun 2.

Department of Physiology, Faculty of Biology, Biomedical Research Institute of Murcia (IMIB)-Arrixaca, University of Murcia, Murcia, Spain;

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http://www.fasebj.org/doi/10.1096/fj.201600269RR
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http://dx.doi.org/10.1096/fj.201600269RRDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001513PMC
September 2016

Demonstration of a day-night rhythm in human skeletal muscle oxidative capacity.

Mol Metab 2016 Aug 1;5(8):635-645. Epub 2016 Jul 1.

Department of Human Biology and Human Movement Sciences, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, PO Box 616, 6200 MD Maastricht, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2016.06.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021670PMC
August 2016

Circadian System and Glucose Metabolism: Implications for Physiology and Disease.

Trends Endocrinol Metab 2016 05 11;27(5):282-293. Epub 2016 Apr 11.

Medical Chronobiology Program, Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA 02115, USA; Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tem.2016.03.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4842150PMC
May 2016

Effects of the Internal Circadian System and Circadian Misalignment on Glucose Tolerance in Chronic Shift Workers.

J Clin Endocrinol Metab 2016 Mar 15;101(3):1066-74. Epub 2016 Jan 15.

Medical Chronobiology Program (C.J.M., T.E.P., J.M., F.A.J.L.S.), Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, Massachusetts 02115; and Division of Sleep Medicine (C.J.M., F.A.J.L.S.), Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115.

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https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.
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http://dx.doi.org/10.1210/jc.2015-3924DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4803172PMC
March 2016

Hungry for Sleep: A Role for Endocannabinoids?

Sleep 2016 Mar 1;39(3):495-6. Epub 2016 Mar 1.

Medical Chronobiology Program, Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA; and Division of Sleep Medicine, Department of Medicine, Harvard Medical School, Boston MA.

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http://dx.doi.org/10.5665/sleep.5510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763352PMC
March 2016

Circadian misalignment increases cardiovascular disease risk factors in humans.

Proc Natl Acad Sci U S A 2016 Mar 8;113(10):E1402-11. Epub 2016 Feb 8.

Medical Chronobiology Program, Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA 02115; Division of Sleep Medicine, Department of Medicine, Harvard Medical School, Boston, MA 02115

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http://dx.doi.org/10.1073/pnas.1516953113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4790999PMC
March 2016

Clock Genes Explain a Large Proportion of Phenotypic Variance in Systolic Blood Pressure and This Control Is Not Modified by Environmental Temperature.

Am J Hypertens 2016 Jan 4;29(1):132-40. Epub 2015 Jun 4.

Nutrition and Genomics Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, USA; Department of Epidemiology, Centro Nacional Investigaciones Cardiovasculares (CNIC), Madrid, Spain; Instituto Madrileño de Estudios Avanzados en Alimentación (IMDEA-FOOD), Madrid, Spain.

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http://dx.doi.org/10.1093/ajh/hpv082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863877PMC
January 2016

Common type 2 diabetes risk variant in MTNR1B worsens the deleterious effect of melatonin on glucose tolerance in humans.

Metabolism 2015 Dec 14;64(12):1650-7. Epub 2015 Aug 14.

Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA; Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.metabol.2015.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856010PMC
December 2015

The Human Circadian System Has a Dominating Role in Causing the Morning/Evening Difference in Diet-Induced Thermogenesis.

Obesity (Silver Spring) 2015 Oct;23(10):2053-8

Medical Chronobiology Program, Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1002/oby.21189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602397PMC
October 2015

Sleep inertia, sleep homeostatic and circadian influences on higher-order cognitive functions.

J Sleep Res 2015 Aug 13;24(4):364-371. Epub 2015 Mar 13.

Sleep and Chronobiology Laboratory, Department of Integrative Physiology, University of Colorado Boulder, Boulder CO, USA.

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http://dx.doi.org/10.1111/jsr.12291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5124508PMC
August 2015

Gene-Environment Interactions of Circadian-Related Genes for Cardiometabolic Traits.

Diabetes Care 2015 Aug 17;38(8):1456-66. Epub 2015 Jun 17.

Nutrition and Genomics Laboratory, Jean Mayer U.S. Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA Department of Epidemiology, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain Instituto Madrileño de Estudios Avanzados en Alimentación (IMDEA-FOOD), Madrid, Spain.

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http://dx.doi.org/10.2337/dc14-2709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4512139PMC
August 2015

Endogenous circadian regulation of pro-inflammatory cytokines and chemokines in the presence of bacterial lipopolysaccharide in humans.

Brain Behav Immun 2015 Jul 13;47:4-13. Epub 2014 Nov 13.

Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, 221 Longwood Ave., Boston, MA 02115, United States; Division of Sleep and Circadian Disorders, Department of Neurology, Brigham and Women's Hospital, 221 Longwood Ave., Boston, MA 02115, United States; Division of Sleep Medicine, Department of Medicine, Harvard Medical School, 164 Longwood Ave., Boston, MA 02115, United States.

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http://dx.doi.org/10.1016/j.bbi.2014.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4430446PMC
July 2015

Endogenous circadian system and circadian misalignment impact glucose tolerance via separate mechanisms in humans.

Proc Natl Acad Sci U S A 2015 Apr 13;112(17):E2225-34. Epub 2015 Apr 13.

Medical Chronobiology Program, Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA 02115; Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115;

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http://dx.doi.org/10.1073/pnas.1418955112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418873PMC
April 2015

Lack of exercise leads to significant and reversible loss of scale invariance in both aged and young mice.

Proc Natl Acad Sci U S A 2015 Feb 9;112(8):2320-4. Epub 2015 Feb 9.

Department of Molecular Cell Biology, Laboratory for Neurophysiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands;

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http://dx.doi.org/10.1073/pnas.1424706112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345576PMC
February 2015

Habitual sleep duration is associated with BMI and macronutrient intake and may be modified by CLOCK genetic variants.

Am J Clin Nutr 2015 Jan 26;101(1):135-43. Epub 2014 Nov 26.

From the Nutrition and Genomics Laboratory (HSD, CES, KR, and JMO), Nutritional Epidemiology Laboratory (PFJ), and Cardiovascular Nutrition Laboratory (SL-F), Jean Mayer U.S. Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA; the Department of Mathematics, Computer Science, and Cooperative Engineering, University of St. Thomas, Houston, TX (JLF); the Translational Gerontology Branch (TT and LF) and Laboratory of Neurogenetics (DGH), National Institute on Aging, Baltimore, MD; the Divisions of Sleep and Circadian Disorders (BEC, DJG, RS, and FAJLS) and Cardiovascular Medicine and Channing Division of Network Medicine (DM), Brigham and Women's Hospital, Boston, MA; the Divisions of Sleep Medicine (BEC, DJG, and FAJLS) and Cardiovascular Medicine and Channing Division of Network Medicine (DM), Harvard Medical School, Boston, MA; the Sleep Disorders Center, VA Boston Healthcare System, Boston, MA (DJG); the Department of Nutrition, Harvard School of Public Health, Boston, MA (AH and DM); the Center for Human Genetic Research and Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA (RS); the Departments of Mental Health and Substance Abuse Services (LK and TP) and Chronic Disease Prevention (M-MP, MP, ASH, VS, and JGE) and National Institute for Health and Welfare (THL), Helsinki, Finland; the Cardiovascular Health Research Unit (TMB, RNL, and BMP), Departments of Medicine (TMB, RNL, BMP, and SAG), Biostatistics (TMB and WCJ), and Epidemiology and Health Services (BMP), Computational Medicine Core (SAG), Center for Lung Biology (SAG), and University of Washington Medicine Sleep Center (SAG), University of Washington, Seattle, WA; The Novo Nordisk Foundation Center for Basic Metabolic Research (AJ, NG, TH, and OP) and Department of Clinical Medicine (AL), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; the USDA

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http://dx.doi.org/10.3945/ajcn.114.095026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266883PMC
January 2015

Meal frequency and timing in health and disease.

Proc Natl Acad Sci U S A 2014 Nov 17;111(47):16647-53. Epub 2014 Nov 17.

Regulatory Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037

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http://dx.doi.org/10.1073/pnas.1413965111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4250148PMC
November 2014

Metabolic effects of sleep disruption, links to obesity and diabetes.

Curr Opin Endocrinol Diabetes Obes 2014 Aug;21(4):293-8

Medical Chronobiology Program, Division of Sleep and Circadian Disorders, Brigham & Women's Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1097/MED.0000000000000082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4370346PMC
August 2014

Simulated shift work in rats perturbs multiscale regulation of locomotor activity.

J R Soc Interface 2014 Jul;11(96)

Medical Biodynamics Program, Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA 02115, USA Medical Chronobiology Program, Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA 02115, USA Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115, USA Center for Dynamical Biomarkers and Translational Medicine, National Central University, Chungli 32001, Taiwan, Republic of China

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http://dx.doi.org/10.1098/rsif.2014.0318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032547PMC
July 2014

Noninvasive fractal biomarker of clock neurotransmitter disturbance in humans with dementia.

Sci Rep 2013 ;3:2229

Medical Biodynamics Program, Division of Sleep Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, United States.

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http://dx.doi.org/10.1038/srep02229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3714649PMC
February 2014

Human circadian system causes a morning peak in prothrombotic plasminogen activator inhibitor-1 (PAI-1) independent of the sleep/wake cycle.

Blood 2014 Jan 7;123(4):590-3. Epub 2013 Nov 7.

Medical Chronobiology Program, Division of Sleep Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA; and.

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http://dx.doi.org/10.1182/blood-2013-07-517060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901072PMC
January 2014

Common variants in CLOCK are not associated with measures of sleep duration in people of european ancestry from the sleep heart health study.

Biol Psychiatry 2013 Dec 17;74(12):e33-5. Epub 2013 Jul 17.

Center for Human Genetic Research and Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston; Program in Medical and Population Genetics, Broad Institute, Cambridge.

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http://dx.doi.org/10.1016/j.biopsych.2013.06.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4157567PMC
December 2013

The role of the circadian system in fractal neurophysiological control.

Biol Rev Camb Philos Soc 2013 Nov 10;88(4):873-94. Epub 2013 Apr 10.

Medical Biodynamics Program, Division of Sleep Medicine, Brigham and Women's Hospital, Boston, MA, 02115, U.S.A.; Medical Chronobiology Program, Division of Sleep Medicine, Brigham and Women's Hospital, Boston, MA, 02115, U.S.A.; Division of Sleep Medicine, Harvard Medical School, Boston, MA, 02115, U.S.A.

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http://dx.doi.org/10.1111/brv.12032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766492PMC
November 2013

Direct effects of light on alertness, vigilance, and the waking electroencephalogram in humans depend on prior light history.

Sleep 2013 Aug 1;36(8):1239-46. Epub 2013 Aug 1.

Division of Sleep Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.

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http://dx.doi.org/10.5665/sleep.2894DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3700721PMC
August 2013

Alterations of melatonin receptors MT1 and MT2 in the hypothalamic suprachiasmatic nucleus during depression.

J Affect Disord 2013 Jun 26;148(2-3):357-67. Epub 2013 Jan 26.

Netherlands Institute for Neuroscience, Institute of Royal Netherlands Academy of Arts and Science, Meibergdreef 47, 1105 BA Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.jad.2012.12.025DOI Listing
June 2013

Day/night variability in blood pressure: influence of posture and physical activity.

Am J Hypertens 2013 Jun 27;26(6):822-8. Epub 2013 Mar 27.

Medical Chronobiology Program, Division of Sleep Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.

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https://academic.oup.com/ajh/article-lookup/doi/10.1093/ajh/
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http://dx.doi.org/10.1093/ajh/hpt026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3693479PMC
June 2013

The internal circadian clock increases hunger and appetite in the evening independent of food intake and other behaviors.

Obesity (Silver Spring) 2013 Mar;21(3):421-3

Medical Chronobiology Program, Division of Sleep Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1002/oby.20351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655529PMC
March 2013

The impact of the circadian timing system on cardiovascular and metabolic function.

Prog Brain Res 2012 ;199:337-358

Division of Sleep Medicine, Brigham and Women's Hospital, Boston, MA, USA; Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1016/B978-0-444-59427-3.00019-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3704149PMC
January 2013

Repeated melatonin supplementation improves sleep in hypertensive patients treated with beta-blockers: a randomized controlled trial.

Sleep 2012 Oct 1;35(10):1395-402. Epub 2012 Oct 1.

Medical Chronobiology Program, Division of Sleep Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.5665/sleep.2122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443766PMC
October 2012

Circadian system, sleep and endocrinology.

Mol Cell Endocrinol 2012 Feb 10;349(1):91-104. Epub 2011 Sep 10.

Division of Sleep Medicine, Brigham and Women's Hospital, Boston, MA, United States.

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http://dx.doi.org/10.1016/j.mce.2011.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3242827PMC
February 2012

Existence of an endogenous circadian blood pressure rhythm in humans that peaks in the evening.

Circ Res 2011 Apr 7;108(8):980-4. Epub 2011 Apr 7.

Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1161/CIRCRESAHA.110.233668DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3086568PMC
April 2011

The human circadian system adapts to prior photic history.

J Physiol 2011 Mar 10;589(Pt 5):1095-102. Epub 2011 Jan 10.

Department of Medicine, Brigham and Women's Hospital/Harvard Medical School, 221 Longwood Avenue, Suite 438, Boston, MA 02115, USA.

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http://dx.doi.org/10.1113/jphysiol.2010.201194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060589PMC
March 2011

Endogenous circadian rhythm in vasovagal response to head-up tilt.

Circulation 2011 Mar 21;123(9):961-70. Epub 2011 Feb 21.

Division of Sleep Medicine, Harvard Medical School, 221 Longwood Ave, 044 BLI, Boston, MA 02115, USA.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.110.943019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3089897PMC
March 2011

Impact of the human circadian system, exercise, and their interaction on cardiovascular function.

Proc Natl Acad Sci U S A 2010 Nov 8;107(47):20541-6. Epub 2010 Nov 8.

Division of Sleep Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1006749107
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http://dx.doi.org/10.1073/pnas.1006749107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996667PMC
November 2010

Acute effects of bright light exposure on cortisol levels.

J Biol Rhythms 2010 Jun;25(3):208-16

Sleep and Chronobiology Laboratory, Department of Integrative Physiology, Center for Neuroscience, University of Colorado, Boulder, Colorado 80309-0354, USA.

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http://dx.doi.org/10.1177/0748730410368413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3686562PMC
June 2010

Effects of circadian disruption on the cardiometabolic system.

Rev Endocr Metab Disord 2009 Dec;10(4):245-60

Division of Sleep Medicine, Harvard Medical School, Brigham and Women's Hospital, 221 Longwood Avenue, Boston, MA 02115, USA.

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http://dx.doi.org/10.1007/s11154-009-9122-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3026852PMC
December 2009

Is there a circadian variation of epileptiform abnormalities in idiopathic generalized epilepsy?

Epilepsy Behav 2009 Nov 27;16(3):461-7. Epub 2009 Sep 27.

Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.yebeh.2009.08.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861150PMC
November 2009

Adverse metabolic and cardiovascular consequences of circadian misalignment.

Proc Natl Acad Sci U S A 2009 Mar 2;106(11):4453-8. Epub 2009 Mar 2.

Division of Sleep Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.0808180106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2657421PMC
March 2009

Reduction of scale invariance of activity fluctuations with aging and Alzheimer's disease: Involvement of the circadian pacemaker.

Proc Natl Acad Sci U S A 2009 Feb 6;106(8):2490-4. Epub 2009 Feb 6.

Division of Sleep Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.0806087106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2650290PMC
February 2009

The circadian pacemaker generates similar circadian rhythms in the fractal structure of heart rate in humans and rats.

Cardiovasc Res 2008 Oct 6;80(1):62-8. Epub 2008 Jun 6.

Division of Sleep Medicine, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA.

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http://dx.doi.org/10.1093/cvr/cvn150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2732059PMC
October 2008

An endogenous circadian rhythm in sleep inertia results in greatest cognitive impairment upon awakening during the biological night.

J Biol Rhythms 2008 Aug;23(4):353-61

Medical Chronobiology Program, Division of Sleep Medicine, Brigham and Women's Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1177/0748730408318081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130065PMC
August 2008

The endogenous circadian pacemaker imparts a scale-invariant pattern of heart rate fluctuations across time scales spanning minutes to 24 hours.

J Biol Rhythms 2008 Jun;23(3):265-73

Division of Sleep Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1177/0748730408316166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2885843PMC
June 2008

Plasticity of the intrinsic period of the human circadian timing system.

PLoS One 2007 Aug 8;2(8):e721. Epub 2007 Aug 8.

Division of Sleep Medicine, Department of Medicine, Brigham & Women's Hospital and Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0000721PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1934931PMC
August 2007

Decreased sleep in heart failure: are medications to blame?

Arch Intern Med 2007 May;167(10):1098-9; author reply 1099-100

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http://dx.doi.org/10.1001/archinte.167.10.1098-bDOI Listing
May 2007

Short-wavelength sensitivity for the direct effects of light on alertness, vigilance, and the waking electroencephalogram in humans.

Sleep 2006 Feb;29(2):161-8

Division of Sleep Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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February 2006

Potential use of melatonin as adjunct antihypertensive therapy.

Am J Hypertens 2005 Dec;18(12 Pt 1):1619-20

Harvard Medical School and Division of Sleep Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1016/j.amjhyper.2005.07.013DOI Listing
December 2005

Melatonin, sleep, and circadian rhythms.

Sleep Med Rev 2005 Feb;9(1):5-9

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http://dx.doi.org/10.1016/j.smrv.2004.11.004DOI Listing
February 2005

Daily nighttime melatonin reduces blood pressure in male patients with essential hypertension.

Hypertension 2004 Feb 19;43(2):192-7. Epub 2004 Jan 19.

Netherlands Institute for Brain Research, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1161/01.HYP.0000113293.15186.3bDOI Listing
February 2004

Light and diurnal cycle affect autonomic cardiac balance in human; possible role for the biological clock.

Auton Neurosci 2004 Jan;110(1):44-8

Project Group Hypothalamic Integration Mechanisms, Netherlands Institute for Brain Research, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.autneu.2003.03.001DOI Listing
January 2004

Human basal cortisol levels are increased in hospital compared to home setting.

Neurosci Lett 2002 Nov;333(2):79-82

Department of Hypothalamic Integration Mechanisms, Netherlands Institute for Brain Research, 1105 AZ, The, Amsterdam, Netherlands.

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http://dx.doi.org/10.1016/s0304-3940(02)00988-6DOI Listing
November 2002