Francoise Le Deist

Francoise Le Deist

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Francoise Le Deist

Francoise Le Deist

Publications by authors named "Francoise Le Deist"

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Mutations in the phosphatidylinositol glycan C () gene are associated with epilepsy and intellectual disability.

J Med Genet 2017 03 30;54(3):196-201. Epub 2016 Sep 30.

Monique and Jacques Roboh Department of Genetic Research, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.

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http://dx.doi.org/10.1136/jmedgenet-2016-104202DOI Listing
March 2017

Variants in TRIM22 That Affect NOD2 Signaling Are Associated With Very-Early-Onset Inflammatory Bowel Disease.

Gastroenterology 2016 05 4;150(5):1196-1207. Epub 2016 Feb 4.

SickKids Inflammatory Bowel Disease Center and Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Toronto, Hospital for Sick Children, Toronto, Ontario, Canada; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00165085160012
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http://dx.doi.org/10.1053/j.gastro.2016.01.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4842103PMC
May 2016

A case of C3 glomerulonephritis successfully treated with eculizumab.

Pediatr Nephrol 2015 Jun 22;30(6):1033-7. Epub 2015 Mar 22.

Department of Pediatrics, Division of Nephrology, CHU Sainte Justine and University of Montreal, 3175 Côte Sainte Catherine, H3T1C5, Montreal, QC, Canada.

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http://link.springer.com/content/pdf/10.1007%2Fs00467-015-30
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http://link.springer.com/10.1007/s00467-015-3061-2
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http://dx.doi.org/10.1007/s00467-015-3061-2DOI Listing
June 2015

Multiple intestinal atresia with combined immune deficiency related to TTC7A defect is a multiorgan pathology: study of a French-Canadian-based cohort.

Medicine (Baltimore) 2014 Dec;93(29):e327

From the Department of Microbiology, Infectiology and Immunology, University of Montreal, Montreal, Canada (IF, EH, FLD); Department of Microbiology and Immunology, CHU Sainte-Justine, Montreal, Canada (IF, FLD); CHU Sainte-Justine Research Center, Montreal, Canada (IF, NP, EH, HD, FLD); Department of Pathology and Cell Biology, CHU Sainte-Justine and University of Montreal, Montreal, Canada (NP); Department of Paediatrics, University of Montreal, Montreal, Canada (VM, EH, HD, FLD); Division of Gastroenterology, Hepatology and Nutrition, CHU Sainte-Justine, Montreal, Canada (VM); Histology Facility, IRIC, University of Montreal, Montreal, Montreal, Canada (MB); Medical Genetics Service, University of Sherbrooke, Sherbrooke, Canada (BM); and Division of Rheumatology, Immunology and Allergology, CHU Sainte-Justine Montreal, Canada (EH, HD, FLD).

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http://dx.doi.org/10.1097/MD.0000000000000327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602622PMC
December 2014

Impaired interferon-alpha production by plasmacytoid dendritic cells after cord blood transplantation in children: implication for post-transplantation toll-like receptor ligand-based immunotherapy.

Biol Blood Marrow Transplant 2014 Oct 14;20(10):1501-7. Epub 2014 Aug 14.

Groupe de Recherche en Transplantation et Immunologie du Sang de Cordon (GRETISC), Centre de Cancérologie Charles Bruneau, Centre de Recherche du CHU Sainte-Justine, Montréal, Québec, Canada; Département de Sciences Biomédicales, Université de Montréal, Québec, Canada; Département de Microbiologie et d'Immunologie, Université de Montréal, Québec, Canada; Département de Pédiatrie, Université de Montréal, Québec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.bbmt.2014.06.007DOI Listing
October 2014

Implication of different effector mechanisms by cord blood-derived and peripheral blood-derived cytokine-induced killer cells to kill precursor B acute lymphoblastic leukemia cell lines.

Cytotherapy 2014 Jun 12;16(6):845-56. Epub 2014 Feb 12.

CHU Sainte-Justine Research Center, Center of Cancerology Charles-Bruneau, Montreal, Quebec, Canada; Department of Microbiology and Immunology, University of Montreal, Montreal, Quebec, Canada; Department of Pediatrics, University of Montreal, Montreal, Quebec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jcyt.2013.12.010DOI Listing
June 2014

Ceftazidime-induced drug reaction with eosinophilia and systemic symptoms (DRESS) complicated by hemophagocytic lymphohistiocytosis.

J Allergy Clin Immunol Pract 2013 Jul-Aug;1(4):409-12. Epub 2013 May 27.

Department of Microbiology and Immunology, CHU Sainte-Justine Research Center, Université de Montréal, Montreal, Quebec, Canada; CHU Sainte-Justine Research Center, Université de Montréal, Montreal, Quebec, Canada; Division of Allergy and Clinical Immunology, Department of Pediatrics, CHU Sainte-Justine, Montreal, Quebec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jaip.2013.04.001DOI Listing
May 2014

Invasive group A Streptococcus disease in French-Canadian children is not associated with a defect in MyD88/IRAK4-pathway.

Allergy Asthma Clin Immunol 2014 Feb 5;10(1). Epub 2014 Feb 5.

Department of Microbiology, Infectiology and Immunology, CHU Sainte-Justine and University of Montreal, Montreal (Quebec), Canada.

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http://dx.doi.org/10.1186/1710-1492-10-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3927219PMC
February 2014

Cord blood-derived and peripheral blood-derived cytokine-induced killer cells are sensitive to Fas-mediated apoptosis.

Biol Blood Marrow Transplant 2013 Sep 12;19(9):1407-11. Epub 2013 Jul 12.

CHU Sainte-Justine Research Center, Center of Cancerology Charles-Bruneau, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1016/j.bbmt.2013.07.007DOI Listing
September 2013

Inflammatory bowel disease and T cell lymphopenia in G6PC3 deficiency.

J Clin Immunol 2013 Apr 20;33(3):520-5. Epub 2012 Nov 20.

Department of Pediatrics, CHU Sainte-Justine and Université de Montréal, Montreal, Canada.

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http://dx.doi.org/10.1007/s10875-012-9833-6DOI Listing
April 2013

Fatal Mycobacterium colombiense/cytomegalovirus coinfection associated with acquired immunodeficiency due to autoantibodies against interferon gamma: a case report.

BMC Infect Dis 2013 Jan 22;13:24. Epub 2013 Jan 22.

Department of Microbiology and Infectious Diseases, Centre Hospitalier Universitaire de Sherbrooke, 3001, 12ème Avenue Nord, Sherbrooke, Quebec J1H 5N4, Canada.

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http://dx.doi.org/10.1186/1471-2334-13-24DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561114PMC
January 2013

Human interferon-alpha increases the cytotoxic effect of CD56(+) cord blood-derived cytokine-induced killer cells on human B-acute lymphoblastic leukemia cell lines.

Cytotherapy 2012 Nov 14;14(10):1245-57. Epub 2012 Sep 14.

CHU Sainte-Justine Research Center, Center of Cancerology Charles-Bruneau, Montreal, Quebec, Canada.

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http://dx.doi.org/10.3109/14653249.2012.714864DOI Listing
November 2012

Secondary pulmonary alveolar proteinosis after unrelated cord blood hematopoietic cell transplantation.

Pediatr Transplant 2012 Aug 13;16(5):E146-9. Epub 2011 Mar 13.

Department of Pediatrics, Hematology Unit, University Hospital Geneva, Geneva, Switzerland.

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http://doi.wiley.com/10.1111/j.1399-3046.2011.01487.x
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http://dx.doi.org/10.1111/j.1399-3046.2011.01487.xDOI Listing
August 2012

Ataxia-telangiectasia presenting with a novel immunodeficiency.

Pediatr Neurol 2012 May;46(5):322-4

Division of Neurology, Department of Pediatrics, Centre Hospitalier Universitaire Sainte-Justine, University of Montreal, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1016/j.pediatrneurol.2012.02.027DOI Listing
May 2012

[Immunodeficiencies and pathologies associated with mutations in STIM/ORAI, a membrane complex in the heart of calcium signalling].

Med Sci (Paris) 2011 Aug-Sep;27(8-9):737-45. Epub 2011 Aug 31.

Département de microbiologie et d'immunologie et centre de recherche, Montréal, Canada.

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http://dx.doi.org/10.1051/medsci/2011278016DOI Listing
November 2011

High prevalence of primary immune deficiencies in children with autoimmune disorders.

Clin Exp Rheumatol 2011 Jan-Feb;29(1):125-30. Epub 2011 Feb 23.

Division of Paediatric Rheumatology and Immunology, University of Montreal, Montreal, Canada.

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May 2011

21-Hydroxylase epitopes are targeted by CD8 T cells in autoimmune Addison's disease.

J Autoimmun 2010 Dec 3;35(4):309-15. Epub 2010 Aug 3.

Endocrinology Service, CHU Sainte-Justine, Department of Pediatrics, Université de Montréal, H3T 1C5 Montréal, Canada.

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http://dx.doi.org/10.1016/j.jaut.2010.07.001DOI Listing
December 2010

ZAP70: a master regulator of adaptive immunity.

Semin Immunopathol 2010 Jun 5;32(2):107-16. Epub 2010 Feb 5.

INSERM, U768, Hôpital Necker-Enfants Malades, Paris, France.

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http://dx.doi.org/10.1007/s00281-010-0196-xDOI Listing
June 2010

Hematopoietic engraftment of XLA bone marrow CD34(+) cells in NOG/SCID mice.

Cytotherapy 2009 ;11(2):198-205

Institut Paoli-Calmettes, Centre de Thérapie Cellulaire et Génique, Marseille, France.

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http://dx.doi.org/10.1080/14653240802716616DOI Listing
November 2009

Length of storage and in vitro immunomodulation induced by prestorage leukoreduced red blood cells.

Transfusion 2009 Nov 17;49(11):2326-34. Epub 2009 Jul 17.

Pediatric Critical Care Unit, the Division of Hematology-Oncology, the Department of Biochemistry, Sainte-Justine Hospital and Université de Montréal, Montréal, Canada.

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http://dx.doi.org/10.1111/j.1537-2995.2009.02319.xDOI Listing
November 2009

Hypomorphic mutation of ZAP70 in human results in a late onset immunodeficiency and no autoimmunity.

Eur J Immunol 2009 Jul;39(7):1966-76

Centre d'Etude des Déficits Immunitaires, Assistance Publique-Hôpitaux de Paris, Hôpital Necker-Enfants Malades, EU, Paris, France.

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http://dx.doi.org/10.1002/eji.200939385DOI Listing
July 2009

Relative CD4 lymphopenia and a skewed memory phenotype are the main immunologic abnormalities in a child with Omenn syndrome due to homozygous RAG1-C2633T hypomorphic mutation.

Clin Immunol 2009 Jun 25;131(3):447-55. Epub 2009 Feb 25.

Division of Allergy and Immunology, Montreal Children's Hospital, McGill University Health Center, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1016/j.clim.2009.01.014DOI Listing
June 2009

Renal granuloma and immunoglobulin M-complex glomerulonephritis: a case of common variable immunodeficiency?

Pediatr Nephrol 2009 Mar 12;24(3):601-4. Epub 2008 Aug 12.

Department of Pediatrics, CHU Sainte-Justine, Université de Montréal, 3175 Chemin de la Côte Sainte-Catherine, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1007/s00467-008-0958-zDOI Listing
March 2009

[Expression anomalies of the CD3-TCR complex expression and immunodeficiencies].

Med Sci (Paris) 2007 Feb;23(2):161-6

Département de microbiologie et d'immunologie, Université de Montréal, CHU Sainte-Justine, 3175, chemin de la Côte Sainte-Catherine, Montréal (Québec), H3T 1C5 Canada.

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http://dx.doi.org/10.1051/medsci/2007232161DOI Listing
February 2007

[Defect in lytic granule exocytosis: several causes, a same effect].

Med Sci (Paris) 2006 Aug-Sep;22(8-9):733-8

Inserm U768, Hôpital Necker-Enfants-Malades, 149, rue de Sèvres, 75015 Paris, France.

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http://dx.doi.org/10.1051/medsci/20062289733DOI Listing
December 2006

Familial NK cell deficiency associated with impaired IL-2- and IL-15-dependent survival of lymphocytes.

J Immunol 2006 Dec;177(12):8835-43

Laboratoire de Génétique Humaine des Maladies Infectieuses, Université de Paris René Descartes-INSERM Unité 550, Faculté de Médecine Necker, 156 rue de Vaugirard, 75015 Paris, France, European Union (EU).

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http://dx.doi.org/10.4049/jimmunol.177.12.8835DOI Listing
December 2006

Mycophenolate mofetil as an alternate immunosuppressor for autoimmune lymphoproliferative syndrome.

J Pediatr Hematol Oncol 2006 Dec;28(12):824-6

1st Pediatric Clinic, University of Athens, Aghia Sophia Children's Hospital, Athens, Greece.

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https://insights.ovid.com/crossref?an=00043426-200612000-000
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http://dx.doi.org/10.1097/MPH.0b013e31802d7503DOI Listing
December 2006

XIAP deficiency in humans causes an X-linked lymphoproliferative syndrome.

Nature 2006 Nov;444(7115):110-4

Inserm 768, Laboratoire du Développement Normal et Pathologique du Système Immunitaire, Univ. René Descartes, Paris, F-75015, France.

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http://dx.doi.org/10.1038/nature05257DOI Listing
November 2006

Kaposi's sarcoma in a child with Wiskott-Aldrich syndrome.

Eur J Pediatr 2006 Jul 7;165(7):453-7. Epub 2006 Apr 7.

Unité d'Immunologie et d'Hématologie Pédiatriques AP-HP, Hôpital Necker-Enfants Malades, 149 rue de Sèvres, 75015, Paris, EU, France.

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http://dx.doi.org/10.1007/s00431-006-0107-2DOI Listing
July 2006

Successful allogeneic hemopoietic stem cell transplantation in a child who had anhidrotic ectodermal dysplasia with immunodeficiency.

Pediatrics 2006 Jul 12;118(1):e205-11. Epub 2006 Jun 12.

Unité d'Immunologie et d'Hématologie Pédiatriques, Institut National de la Santé et de la Recherche Médicale U429, Hôpital Necker-Enfants Malades, Paris, France.

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http://dx.doi.org/10.1542/peds.2005-2661DOI Listing
July 2006

Omenn syndrome in an infant with IL7RA gene mutation.

J Pediatr 2006 Feb;148(2):272-4

Department of Pediatrics and Angelo Nocivelli Institute for Molecular Medicine, University of Brescia, Spedali Civili, 25123 Brescia, Italy.

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http://dx.doi.org/10.1016/j.jpeds.2005.10.004DOI Listing
February 2006

Severe combined immunodeficiency and microcephaly in siblings with hypomorphic mutations in DNA ligase IV.

Eur J Immunol 2006 Jan;36(1):224-35

INSERM, Hôpital Necker Enfants-Malades, U429, Unité Développement Normal et Pathologique du Système Immunitaire, Paris, France.

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http://dx.doi.org/10.1002/eji.200535401DOI Listing
January 2006

CD3 deficiencies.

Curr Opin Allergy Clin Immunol 2005 Dec;5(6):491-5

Department of Pediatric Immuno-Hematology and Inserm Unit 429, Necker-Enfants Malades Hospital, Paris, France.

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http://dx.doi.org/10.1097/01.all.0000191886.12645.79DOI Listing
December 2005

The repair of DNA damages/modifications during the maturation of the immune system: lessons from human primary immunodeficiency disorders and animal models.

Adv Immunol 2005 ;87:237-95

Développement Normal et Pathologique du Système Immunitaire, INSERM U429, Hôpital Necker, Paris, France.

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http://dx.doi.org/10.1016/S0065-2776(05)87007-5DOI Listing
September 2005

Severe and progressive encephalitis as a presenting manifestation of a novel missense perforin mutation and impaired cytolytic activity.

Blood 2005 Apr 14;105(7):2658-63. Epub 2004 Dec 14.

Inistitut National de la Santé et de la Recherche Médicale (INSERM) U429, Hôpital Necker-Enfants Malades, 149 rue de Sèvres, 75743 Paris, Cedex 15, France.

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http://dx.doi.org/10.1182/blood-2004-09-3590DOI Listing
April 2005

Ca2+ ionophores trigger membrane remodeling without a need for store-operated Ca2+ entry.

Biochem Biophys Res Commun 2005 Feb;327(1):335-41

INSERM Unité 143, 80 rue du Général Leclerc, 94276, Le Kremlin-Bicêtre, France.

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http://dx.doi.org/10.1016/j.bbrc.2004.12.018DOI Listing
February 2005

[Severe combined immunodeficiency: susceptibility to HPV?].

Med Sci (Paris) 2005 Feb;21(2):125-7

Centre d'étude des déficits immunitaires, Hôpital Necker-Enfants malades, 149, rue de Sèvres, 75015 Paris, France.

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http://dx.doi.org/10.1051/medsci/2005212125DOI Listing
February 2005

Autoimmune lymphoproliferative syndrome and perforin.

N Engl J Med 2005 Jan;352(3):306-7; author reply 306-7

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http://dx.doi.org/10.1056/NEJM200501203520319DOI Listing
January 2005

Artemis sheds new light on V(D)J recombination.

Immunol Rev 2004 Aug;200:142-55

Développement Normal et Pathologique du Système Immunitaire, INSERM U429, Paris, France.

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http://dx.doi.org/10.1111/j.0105-2896.2004.00169.xDOI Listing
August 2004

Cell-death signaling and human disease.

Curr Opin Immunol 2003 Jun;15(3):325-31

Institut National de la santé et de la Recherche Médicale U429, Hôpital Necker Enfants Malades, 149 rue de Sèvres, 75743 Paris Cedex 15, France.

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http://dx.doi.org/10.1016/s0952-7915(03)00042-6DOI Listing
June 2003

Mechanisms of CD47-induced caspase-independent cell death in normal and leukemic cells: link between phosphatidylserine exposure and cytoskeleton organization.

Blood 2002 Oct;100(8):2882-90

Centre de Recherche du Centre Hospitalier Université Montreal, Laboratoire d' Immunorégulation, Université de Montréal, Canada.

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http://dx.doi.org/10.1182/blood-2001-12-0217DOI Listing
October 2002

Differential sensitivity of Jurkat and primary T cells to caspase-independent cell death triggered upon Fas stimulation.

Eur J Immunol 2002 Aug;32(8):2376-84

INSERM U429, Développement Normal et Pathologique du Système Immunitaire, Hôpital Necker-Enfants Malades, Paris, France.

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http://dx.doi.org/10.1002/1521-4141(200208)32:8<2376::AID-IMMU2376>3.0.CO;2-VDOI Listing
August 2002

Functional consequences of perforin gene mutations in 22 patients with familial haemophagocytic lymphohistiocytosis.

Br J Haematol 2002 Jun;117(4):965-72

Unité de Recherche sur le développement normal et pathologique du système immunitaire, INSERM U429, Hôpital Necker-Enfants Malades, 149 rue de Sevres, 75743 Paris cedex 15, France.

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http://dx.doi.org/10.1046/j.1365-2141.2002.03534.xDOI Listing
June 2002

Improving immune reconstitution while preventing graft-versus-host disease in allogeneic stem cell transplantation.

Semin Hematol 2002 Jan;39(1):32-40

Laboratoire de Thérapie Cellulaire et Génique, INSERM U429, Hôpital Necker-Enfants Malades, Paris, France.

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http://dx.doi.org/10.1053/shem.2002.29251DOI Listing
January 2002