Francoise Redini

Francoise Redini

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Francoise Redini

Francoise Redini

Publications by authors named "Francoise Redini"

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Genetically-achieved disturbances to the expression levels of TNFSF11 receptors modulate the effects of zoledronic acid on growing mouse skeletons.

Biochem Pharmacol 2019 Oct 28;168:133-148. Epub 2019 Jun 28.

INSERM, UMR-1238, Equipe 1, Faculté de Médecine, Université de Nantes, Nantes F-44035, France. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2019.06.027DOI Listing
October 2019

New Insights about the Wnt/β-Catenin Signaling Pathway in Primary Bone Tumors and Their Microenvironment: A Promising Target to Develop Therapeutic Strategies?

Int J Mol Sci 2019 Jul 31;20(15). Epub 2019 Jul 31.

Université de Nantes, INSERM, UMR1238, Phy-OS, Sarcomes Osseux et Remodelage des Tissus Calcifiés, 44035 Nantes, France.

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http://dx.doi.org/10.3390/ijms20153751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6696068PMC
July 2019

Jaw osteosarcoma models in mice: first description.

J Transl Med 2019 Feb 27;17(1):56. Epub 2019 Feb 27.

Laboratoire des sarcomes osseux et remodelage des tissus calcifiés (Phy.OS), UMR 1238, Faculté de médecine, 1 rue Gaston Veil, 44035, Nantes Cedex, France.

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http://dx.doi.org/10.1186/s12967-019-1807-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391788PMC
February 2019

Paradoxical side effects of bisphosphonates on the skeleton: What do we know and what can we do?

J Cell Physiol 2018 08 7;233(8):5696-5715. Epub 2018 Mar 7.

UMR-1238, INSERM, Equipe 1, Faculté de Médecine de l'Université de Nantes, Nantes, France.

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http://dx.doi.org/10.1002/jcp.26465DOI Listing
August 2018

Transforming Growth Factor-β Signaling Plays a Pivotal Role in the Interplay Between Osteosarcoma Cells and Their Microenvironment.

Front Oncol 2018 30;8:133. Epub 2018 Apr 30.

UMR1238 INSERM, Université de Nantes, PHY-OS, "Bone Sarcomas and Remodeling of Calcified Tissues", Medical School, Nantes, France.

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http://dx.doi.org/10.3389/fonc.2018.00133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937053PMC
April 2018

Proteoglycan-targeting applied to hypoxia-activated prodrug therapy in chondrosarcoma: first proof-of-concept.

Oncotarget 2017 Nov 27;8(56):95824-95840. Epub 2017 Sep 27.

Université Clermont Auvergne, INSERM, U1240 Imagerie Moléculaire et Stratégies Théranostiques, Clermont-Ferrand, France.

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http://dx.doi.org/10.18632/oncotarget.21337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707064PMC
November 2017

Doxycycline and its quaternary ammonium derivative for adjuvant therapies of chondrosarcoma.

Cancer Chemother Pharmacol 2017 Sep 13;80(3):517-526. Epub 2017 Jul 13.

Centre Jean Perrin, INSERM, U1240 Imagerie Moléculaire et Stratégies Théranostiques, Université Clermont Auvergne, 63000, Clermont-Ferrand, France.

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http://dx.doi.org/10.1007/s00280-017-3377-7DOI Listing
September 2017

TRAIL delivered by mesenchymal stromal/stem cells counteracts tumor development in orthotopic Ewing sarcoma models.

Int J Cancer 2016 Dec 12;139(12):2802-2811. Epub 2016 Sep 12.

INSERM, UMR-957, Equipe labellisée LIGUE contre le CANCER 2012, Nantes, F-44035, France.

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http://dx.doi.org/10.1002/ijc.30402DOI Listing
December 2016

[Which approach of therapeutic education (TE) for adolescents and young adults with cancer? Experience from the TE working group of "Go-AJA"].

Bull Cancer 2016 Dec 15;103(12):966-978. Epub 2016 Nov 15.

Cancer campus Gustave-Roussy, département de cancérologie de l'enfant et l'adolescent, équipe transversale SPIAJA, 114, rue Edouard-Vaillant, 94800 Villejuif, France.

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http://dx.doi.org/10.1016/j.bulcan.2016.10.006DOI Listing
December 2016

TGF-β Signaling in Bone Remodeling and Osteosarcoma Progression.

J Clin Med 2016 Nov 3;5(11). Epub 2016 Nov 3.

INSERM, UMR 957, Equipe Labellisée Ligue contre le Cancer 2012, Faculté de Médecine, 1 rue Gaston Veil, 44035 Nantes cedex, France.

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http://www.mdpi.com/2077-0383/5/11/96
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http://dx.doi.org/10.3390/jcm5110096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5126793PMC
November 2016

Severe compromise of preosteoblasts in a surgical mouse model of bisphosphonate-associated osteonecrosis of the jaw.

J Craniomaxillofac Surg 2016 Sep 22;44(9):1387-94. Epub 2016 Jul 22.

INSERM, UMR 957, Equipe Ligue Contre le Cancer 2012, 1 rue Gaston Veil, Nantes Cedex 1, 44035, Nantes, France; University of Nantes, Nantes Atlantique Universities, Pathophysiology of Bone Resorption and Therapy of Primary Bone Tumours Laboratory, 1 rue Gaston Veil, Nantes Cedex 1, 44035, Nantes, France; Nantes University Hospital, 1 Place Alexis-Ricordeau, 44093, Nantes Cedex 1, France; Department of Oncology and Metabolism, Medical School, Beech Hill Road, S10 2RX, Sheffield, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jcms.2016.07.015DOI Listing
September 2016

Blocking HSP90 Addiction Inhibits Tumor Cell Proliferation, Metastasis Development, and Synergistically Acts with Zoledronic Acid to Delay Osteosarcoma Progression.

Clin Cancer Res 2016 05 28;22(10):2520-33. Epub 2015 Dec 28.

Université de Nantes, Nantes atlantique universités, Laboratoire de Physiopathologie de la Résorption Osseuse et Thérapie des Tumeurs Osseuses Primitives, Nantes, France. INSERM, UMR 957, Nantes, France. LUNAM Université, Nantes, France. Equipe labellisée LIGUE 2012, Nantes, France.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-1925DOI Listing
May 2016

L-MTP-PE and zoledronic acid combination in osteosarcoma: preclinical evidence of positive therapeutic combination for clinical transfer.

Am J Cancer Res 2016 15;6(3):677-89. Epub 2016 Feb 15.

INSERM, UMR-957, Equipe Ligue Contre le Cancer 2012Nantes, F-44035, France; Université de Nantes, Faculté de Médecine, Laboratoire De Physiopathologie De La Résorption Osseuse Et Thérapie Des Tumeurs Osseuses PrimitivesNantes, F-44035, France; CHU Hôtel DieuNantes, F-44035, France.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4851846PMC
May 2016

Opposite Effects of Soluble Factors Secreted by Adipose Tissue on Proliferating and Quiescent Osteosarcoma Cells.

Plast Reconstr Surg 2016 Mar;137(3):865-75

Nantes and Tours, France From INSERM, UMR 957, Equipe Labellisée Ligue contre le Cancer 2012; the Université de Nantes, Nantes Atlantique Universités, Laboratoire de Physiopathologie de la Résorption Osseuse et Thérapie des Tumeurs Osseuses Primitives; University Hospital, Service de Chirurgie Plastique et des Brûlés and Service d'Anatomie Pathologique; and University Hospital, Service d'Anatomie Pathologique.

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http://dx.doi.org/10.1097/01.prs.0000479989.88114.8bDOI Listing
March 2016

Bone Tumor Environment as a Potential Therapeutic Target in Ewing Sarcoma.

Front Oncol 2015 23;5:279. Epub 2015 Dec 23.

INSERM UMR_S 957, Nantes, France; Equipe labellisée Ligue contre le Cancer 2012, Nantes, France; Laboratoire de Physiopathologie de la Résorption osseuse et Thérapie des tumeurs osseuses primitives, Faculté de Médecine, Nantes, France; CHU Hôtel-Dieu, Nantes, France.

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http://dx.doi.org/10.3389/fonc.2015.00279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4688361PMC
January 2016

TRAIL-based therapy in pediatric bone tumors: how to overcome resistance.

Future Oncol 2015 ;11(3):535-42

INSERM, Nantes, France.

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http://dx.doi.org/10.2217/fon.14.293DOI Listing
November 2015

Skeletal consequences of RANKL-blocking antibody (IK22-5) injections during growth: mouse strain disparities and synergic effect with zoledronic acid.

Bone 2015 Apr 20;73:51-9. Epub 2014 Dec 20.

INSERM, UMR-957, Equipe Ligue Nationale Contre le Cancer 2012, Nantes F-44035, France; Université de Nantes, Faculté de Médecine, Laboratoire de physiopathologie de la résorption osseuse et thérapie des tumeurs osseuses primitives, Nantes F-44035, France.

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http://dx.doi.org/10.1016/j.bone.2014.12.011DOI Listing
April 2015

Oncostatin m, an inflammatory cytokine produced by macrophages, supports intramembranous bone healing in a mouse model of tibia injury.

Am J Pathol 2015 Mar 2;185(3):765-75. Epub 2015 Jan 2.

INSERM, UMR 957, Ligue Team 2012, Nantes, France; Pathophysiology of Bone Resorption Laboratory and Therapy of Primary Bone Tumors, Medicine Faculty, Université de Nantes, Nantes Atlantique Universités, Nantes, France. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2014.11.008DOI Listing
March 2015

BYL719, a new α-specific PI3K inhibitor: single administration and in combination with conventional chemotherapy for the treatment of osteosarcoma.

Int J Cancer 2015 Feb 30;136(4):784-96. Epub 2014 Jun 30.

INSERM, UMR 957, Nantes, 44035, France; Université de Nantes, Physiopathologie de la Résorption Osseuse et Thérapie des Tumeurs Osseuses Primitives, Nantes, 44035, France.

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http://dx.doi.org/10.1002/ijc.29040DOI Listing
February 2015

Imatinib mesylate exerts anti-proliferative effects on osteosarcoma cells and inhibits the tumour growth in immunocompetent murine models.

PLoS One 2014 5;9(3):e90795. Epub 2014 Mar 5.

INSERM, UMR 957, Nantes, France; Université de Nantes, Nantes Atlantique Universités, Physiopathologie de la Résorption Osseuse et Thérapie des Tumeurs Osseuses Primitives, Nantes, France; Equipe LIGUE Nationale Contre le Cancer 2012, Nantes, France; CHU de Nantes, Nantes, France.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0090795PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944320PMC
November 2014

Small rigid platforms functionalization with quaternary ammonium: targeting extracellular matrix of chondrosarcoma.

Nanomedicine 2014 Nov 25;10(8):1887-95. Epub 2014 Jun 25.

Institut Lumière Matière, UMR 5306 Université Lyon1-CNRS, Université de Lyon, 69622 Villeurbanne cédex, France; Hospices Civils de Lyon, Hôpital Edouard Herriot, 69000 Lyon, France.

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http://dx.doi.org/10.1016/j.nano.2014.06.011DOI Listing
November 2014

Preclinical evidence of potential craniofacial adverse effect of zoledronic acid in pediatric patients with bone malignancies.

Bone 2014 Nov 2;68:146-52. Epub 2014 Sep 2.

INSERM, UMR-957, Nantes, F-44035, France; Université de Nantes Nantes Atlantique Université, Faculté de Médecine, Laboratoire de physiopathologie de la résorption osseuse et thérapie des tumeurs osseuses primitives, Nantes F-44035, France. Electronic address:

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http://dx.doi.org/10.1016/j.bone.2014.08.018DOI Listing
November 2014

Overexpression of smad7 blocks primary tumor growth and lung metastasis development in osteosarcoma.

Clin Cancer Res 2014 Oct 8;20(19):5097-112. Epub 2014 Aug 8.

INSERM, UMR 957, Equipe labellisée Ligue contre le Cancer 2012, Nantes, France. Université de Nantes, Laboratoire de Physiopathologie de la Résorption Osseuse et Thérapie des Tumeurs Osseuses Primitives, Nantes, France. CHU Hôtel Dieu, Nantes, France.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-3191DOI Listing
October 2014

Clusterin inhibition using OGX-011 synergistically enhances zoledronic acid activity in osteosarcoma.

Oncotarget 2014 Sep;5(17):7805-19

Université de Nantes, Nantes atlantique universités, Laboratoire de Physiopathologie de la Résorption Osseuse et Thérapie des Tumeurs Osseuses Primitives, Nantes F-44035, France. INSERM, UMR 957, Nantes F-44035, France. LUNAM Université. Equipe labellisée LIGUE 2012, Nantes, cedex.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202162PMC
http://dx.doi.org/10.18632/oncotarget.2308DOI Listing
September 2014

NVP-BEZ235, a dual PI3K/mTOR inhibitor, inhibits osteosarcoma cell proliferation and tumor development in vivo with an improved survival rate.

Cancer Lett 2014 Mar 11;344(2):291-8. Epub 2013 Dec 11.

INSERM, UMR 957, Equipe LIGUE Nationale Contre le Cancer 2012, Nantes 44035, France; Université de Nantes, Nantes atlantique universités, Pathophysiology of Bone Resorption and Therapy of Primary Bone Tumors, Nantes, France; Nanrtes University Hospital, rue Gaston Veil, 44035, Nantes, France. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2013.11.017DOI Listing
March 2014

Selective inhibition of BET bromodomain epigenetic signalling interferes with the bone-associated tumour vicious cycle.

Nat Commun 2014 Mar 19;5:3511. Epub 2014 Mar 19.

1] INSERM, UMR 957, Équipe labellisée ligue 2012, 1 Rue Gaston Veil, Nantes 44035, France [2] Physiopathologie de la Résorption Osseuse et Thérapie des Tumeurs Osseuses Primitives, Université de Nantes, Nantes Atlantique Universités, EA3822, 1 Rue Gaston Veil, Nantes 44035, France.

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http://dx.doi.org/10.1038/ncomms4511DOI Listing
March 2014

Osteoprotegerin: multiple partners for multiple functions.

Cytokine Growth Factor Rev 2013 Oct 1;24(5):401-9. Epub 2013 Jul 1.

INSERM, UMR957, Nantes F-44035, France; Université de Nantes, Nantes atlantique universités, Laboratoire de Physiopathologie de la Résorption Osseuse et Thérapie des Tumeurs Osseuses Primitives, Nantes F-44035, France; CHU, Hôtel Dieu, Nantes, France. Electronic address:

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http://dx.doi.org/10.1016/j.cytogfr.2013.06.001DOI Listing
October 2013

New chondrosarcoma cell lines and mouse models to study the link between chondrogenesis and chemoresistance.

Lab Invest 2013 Oct 19;93(10):1100-14. Epub 2013 Aug 19.

1] INSERM, UMR 957, Equipe Labellisée LIGUE 2012, Nantes, France [2] Université de Nantes, Nantes Atlantique Universités, Laboratoire de Physiopathologie de la Résorption Osseuse et Thérapie des Tumeurs Osseuses Primitives, Nantes, France [3] Atlantic Bone Screen (ABS), St Herblain, France.

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http://dx.doi.org/10.1038/labinvest.2013.101DOI Listing
October 2013

Drugs targeting the bone microenvironment: new therapeutic tools in Ewing's sarcoma?

Expert Opin Emerg Drugs 2013 Sep 20;18(3):339-52. Epub 2013 Aug 20.

INSERM, UMR-957, Equipe Ligue Contre le Cancer 2012 , Nantes, F-44035, France.

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http://dx.doi.org/10.1517/14728214.2013.823948DOI Listing
September 2013

Osteoprotegerin inhibits bone resorption and prevents tumor development in a xenogenic model of Ewing's sarcoma by inhibiting RANKL.

J Bone Oncol 2013 Sep 20;2(3):95-104. Epub 2013 May 20.

INSERM, Equipe Ligue Contre le Cancer 2012, UMR-957, Nantes F-44035, France; Université de Nantes, EA3822, Faculté de Médecine, Laboratoire de physiopathologie de la résorption osseuse et thérapie des tumeurs osseuses primitives, Nantes F-44035, France.

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http://dx.doi.org/10.1016/j.jbo.2013.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4723385PMC
September 2013

Targeted therapies for bone sarcomas.

Bonekey Rep 2013 Jul 17;2:378. Epub 2013 Jul 17.

INSERM, UMR 957, Faculty of Medicine, University of Nantes , Nantes, France ; Faculté de Médecine, Université de Nantes, Nantes Atlantique Universités, Laboratoire de Physiopathologie de la Résorption Osseuse et Thérapie des Tumeurs Osseuses Primitives , Nantes, France ; University Hospital, Hôtel Dieu , CHU de Nantes, France ; Equipe Labellisée Ligue Nationale Contre le Cancer 2012 , Nantes, France.

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http://dx.doi.org/10.1038/bonekey.2013.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817966PMC
July 2013

A Disintegrin And Metalloproteinase 12 produced by tumour cells accelerates osteosarcoma tumour progression and associated osteolysis.

Eur J Cancer 2013 Jun 13;49(9):2253-63. Epub 2013 Mar 13.

LUNAM Université, France; INSERM, UMR-S 957, Nantes, France; Université de Nantes, Laboratoire de Physiopathologie de la Résorption Osseuse et Thérapie des Tumeurs Osseuses Primitives, Nantes, France; CHU de Nantes, Nantes, France; Equipe labellisée Ligue contre le Cancer 2012, Nantes, France. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2013.02.020DOI Listing
June 2013

Current therapeutic strategies and novel approaches in osteosarcoma.

Cancers (Basel) 2013 May 24;5(2):591-616. Epub 2013 May 24.

INSERM, UMR 957, 1 Rue Gaston Veil, 44035 Nantes, France.

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http://dx.doi.org/10.3390/cancers5020591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730336PMC
May 2013

In vivo evidence of the targeting of cartilaginous tissue by pyridinium functionalized nanoparticles.

Chem Commun (Camb) 2013 Apr;49(29):3046-8

Laboratoire de Physico-Chimie des Matériaux Luminescents, UMR 5620 CNRS - Université Claude Bernard Lyon 1, Université de Lyon, 69622 Villeurbanne Cedex, France.

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http://dx.doi.org/10.1039/c3cc39106jDOI Listing
April 2013

Bone sarcomas: from biology to targeted therapies.

Sarcoma 2012 27;2012:301975. Epub 2012 Nov 27.

Department of Oncology for Children and Adolescents, Institut Gustave Roussy, 114 rue Edouard Vaillant, 94805 Villejuif Cedex, France.

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http://dx.doi.org/10.1155/2012/301975DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514839PMC
December 2012

Oncostatin M is a growth factor for Ewing sarcoma.

Am J Pathol 2012 Nov 13;181(5):1782-95. Epub 2012 Sep 13.

INSERM, UMR, Ligue Team 2012, Nantes, France.

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http://dx.doi.org/10.1016/j.ajpath.2012.07.023DOI Listing
November 2012

Targeting the EWSR1-FLI1 oncogene-induced protein kinase PKC-β abolishes ewing sarcoma growth.

Cancer Res 2012 Sep 28;72(17):4494-503. Epub 2012 Aug 28.

Institut Curie, INSERM U830, Unité de Génétique et Biologie des Cancers, Institut Curie, Unité de génétique somatique, Paris, France.

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http://dx.doi.org/10.1158/0008-5472.CAN-12-0371DOI Listing
September 2012

Molecular alterations associated with osteosarcoma development.

Sarcoma 2012 15;2012:523432. Epub 2012 Feb 15.

INSERM, UMR-S 957, 1 Rue Gaston Veil, 44035 Nantes, France.

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http://dx.doi.org/10.1155/2012/523432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3289857PMC
August 2012

Proteoglycans: complex diversity in structure and functions.

Methods Mol Biol 2012 ;836:vii-viii

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http://dx.doi.org/10.1007/978-1-61779-498-8DOI Listing
May 2012

A functional, new short isoform of death receptor 4 in Ewing's sarcoma cell lines may be involved in TRAIL sensitivity/resistance mechanisms.

Mol Cancer Res 2012 Mar 18;10(3):336-46. Epub 2012 Jan 18.

1INSERM, Equipe labellisee LIGUE 2012 UMR 957, Laboratoire de Physiopathologie de la Résorption Osseuse et Thérapie des Tumeurs Osseuses Primitives, EA3822, Nantes, France.

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http://dx.doi.org/10.1158/1541-7786.MCR-11-0390DOI Listing
March 2012

Synergistic inhibitory effect of apomine and lovastatin on osteosarcoma cell growth.

Cancer 2012 Feb 12;118(3):750-60. Epub 2011 Jul 12.

National Institute of Health and Medical Research, Nantes, France.

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http://dx.doi.org/10.1002/cncr.26336DOI Listing
February 2012

Mifamurtide for the treatment of nonmetastatic osteosarcoma.

Expert Opin Pharmacother 2011 Feb;12(2):285-92

Shiga University of Medical Science, Department of Orthopaedic Surgery, Otsu, Shiga, Japan.

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http://www.tandfonline.com/doi/full/10.1517/14656566.2011.54
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http://dx.doi.org/10.1517/14656566.2011.543129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413631PMC
February 2011

Proteoglycans on bone tumor development.

Drug Discov Today 2010 Jul 27;15(13-14):553-60. Epub 2010 May 27.

Université de Nantes, France.

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http://dx.doi.org/10.1016/j.drudis.2010.05.009DOI Listing
July 2010

Preclinical evidence that use of TRAIL in Ewing's sarcoma and osteosarcoma therapy inhibits tumor growth, prevents osteolysis, and increases animal survival.

Clin Cancer Res 2010 Apr 6;16(8):2363-74. Epub 2010 Apr 6.

Institut National de la Sante et de la Recherche Medicale UMR_S 957, Université de Nantes EA 3822, Nantes Atlantique Universités, Physiopathologie de la Résorption Osseuse et Thérapie des Tumeurs Osseuses Primitives, Nantes, France.

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http://dx.doi.org/10.1158/1078-0432.CCR-09-1779DOI Listing
April 2010

Glycosaminoglycans as potential regulators of osteoprotegerin therapeutic activity in osteosarcoma.

Cancer Res 2009 Jan;69(2):526-36

Faculté de Médecine, Laboratoire de Physiopathologie de la Résorption Osseuse, Institut National de la Sante et de la Recherche Medicale ERI 7, Université de Nantes, Nantes cedex 1, France.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-2648DOI Listing
January 2009

Killer dendritic cells link innate and adaptive immunity against established osteosarcoma in rats.

Cancer Res 2008 Nov;68(22):9433-40

Institut National de la Sante et de la Recherche Medicale, U643, CHU Nantes, Institut de Transplantation et de Recherche en Transplantation-Urologie-Néphrologie, IUN, Université de Nantes, Faculté de Médecine, France.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-0104DOI Listing
November 2008

Therapeutic efficacy of soluble receptor activator of nuclear factor-kappa B-Fc delivered by nonviral gene transfer in a mouse model of osteolytic osteosarcoma.

Mol Cancer Ther 2008 Oct;7(10):3389-98

INSERM, ERI 7, Université de Nantes, Nantes atlantique universités, Laboratoire de Physiopathologie de la Résorption Osseuse et Thérapie des Tumeurs Osseuses Primitives, EA3822, 1 rue Gaston Veil, 44035 Nantes cedex 1, France.

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http://dx.doi.org/10.1158/1535-7163.MCT-08-0497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2772022PMC
October 2008

RANKL/RANK/OPG: key therapeutic target in bone oncology.

Curr Drug Discov Technol 2008 Sep;5(3):263-8

Department of Orthopaedic Surgery, Shiga University of Medical Science, Otsu, Shiga, Japan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661019PMC
September 2008

Receptor activator of nuclear factor-kappaB ligand (RANKL) directly modulates the gene expression profile of RANK-positive Saos-2 human osteosarcoma cells.

Oncol Rep 2007 Dec;18(6):1365-71

Université de Nantes, Nantes Atlantique Universités, Laboratoire de Physiopathologie de Résorption Osseuse et Thérapie des Tumeurs Osseuses Primitives, EA3822, Nantes, F-44035, France.

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December 2007

mTOR inhibitors (rapamycin and its derivatives) and nitrogen containing bisphosphonates: bi-functional compounds for the treatment of bone tumours.

Curr Med Chem 2007 ;14(13):1381-7

INSERM ERI 7, Faculté de Médecine, 1 rue Gatson Veil, 44035 Nantes cedex 1, F-44035 France.

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http://dx.doi.org/10.2174/092986707780831159DOI Listing
September 2007

Proteoglycans: key partners in bone cell biology.

Bioessays 2007 Aug;29(8):758-71

EA3822-INSERM ERI7, Physiopathologie de la Résorption Osseuse et Thérapie des Tumeurs Osseuses Primitives, Faculté de Médecine, 1 rue Gaston Veil, 44035 Nantes cedex 1, France.

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http://dx.doi.org/10.1002/bies.20612DOI Listing
August 2007

Therapeutic relevance of osteoprotegerin gene therapy in osteosarcoma: blockade of the vicious cycle between tumor cell proliferation and bone resorption.

Cancer Res 2007 Aug;67(15):7308-18

Institut National de la Sante et de la Recherche Medicale (INSERM), ERI 7, Université de Nantes, Nantes Atlantique Universités, Laboratoire de Physiopathologie de la Résorption Osseuse et Thérapie des Tumeurs Osseuses Primitives, Nantes, France.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-4130DOI Listing
August 2007

mTOR inhibitors (rapamycin and its derivatives) and nitrogen containing bisphosphonates: bi-functional compounds for the treatment of bone tumours.

Curr Med Chem 2007 ;14(13):1381-7

INSERM ERI 7, Faculté de Médecine, 1 rue Gatson Veil, 44035 Nantes cedex 1, F-44035 France.

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http://dx.doi.org/10.2174/092986707780831159DOI Listing
September 2007

Osteosarcoma: current status of immunotherapy and future trends (Review).

Oncol Rep 2006 Mar;15(3):693-700

Université de Nantes EA 3822, INSERM ERI 7, Physiopathologie de la Résorption Osseuse et Thérapie des Tumeurs Osseuses Primitives, Faculté de Médecine, 44035 Nantes cedex 1, France.

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March 2006

RANKL directly induces bone morphogenetic protein-2 expression in RANK-expressing POS-1 osteosarcoma cells.

Int J Oncol 2006 Jan;28(1):261-9

Université de Nantes EA 3822, INSERM ERI 7, Physiopathologie de la Résorption Osseuse et Thérapie des Tumeurs Osseuses Primitives, Faculté de Médecine, 44035 Nantes cedex 1, France.

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January 2006

Zoledronic acid suppresses lung metastases and prolongs overall survival of osteosarcoma-bearing mice.

Cancer 2005 Dec;104(11):2522-9

Universite de Nantes EA 3822; INSERM ERI 7, Physiopathologie de la Resorption Osseuse et Therapie des Tumeurs Osseuses Primitives, Faculte de Medecine, Nantes, France.

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http://dx.doi.org/10.1002/cncr.21530DOI Listing
December 2005

Osteolytic bone diseases: physiological analogues of bone resorption effectors as alternative therapeutic tools.

Drug Discov Today 2005 Feb;10(4):242-7

Pathophysiology of Bone Resorption Laboratory and Therapy of Primitive Bone Tumors, EA3822, INSERM ERI 7, Medicine Faculty, 1 rue Gaston Veil, 44035 Nantes cedex 1, France.

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http://linkinghub.elsevier.com/retrieve/pii/S135964460403265
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http://dx.doi.org/10.1016/S1359-6446(04)03265-9DOI Listing
February 2005

The molecular triad OPG/RANK/RANKL: involvement in the orchestration of pathophysiological bone remodeling.

Cytokine Growth Factor Rev 2004 Dec;15(6):457-75

EA 3822, INSERM ESPRI, Physiopathologie de la Résorption Osseuse et Thérapie des Tumeurs Osseuses Primitives, Faculté de Médecine, 1 rue Gaston Veil, 44035 Nantes Cedex 1, France.

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http://dx.doi.org/10.1016/j.cytogfr.2004.06.004DOI Listing
December 2004

Downregulation of osteoblast markers and induction of the glial fibrillary acidic protein by oncostatin M in osteosarcoma cells require PKCdelta and STAT3.

J Bone Miner Res 2004 Nov 23;19(11):1850-61. Epub 2004 Aug 23.

Laboratory of Pathophysiology of Bone Resorption and Therapy of Primitive Bone Tumors, INSERM ESPRI, Nantes, France.

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http://dx.doi.org/10.1359/JBMR.040817DOI Listing
November 2004

Bisphosphonates: new therapeutic agents for the treatment of bone tumors.

Trends Mol Med 2004 Jul;10(7):337-43

Laboratoire de Physiopathologie de la Résorption Osseuse et Thérapie des Tumeurs Osseuses Primitives. Faculté de Médecine, 1 rue Gaston Veil, 44035 Nantes 1, France.

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http://dx.doi.org/10.1016/j.molmed.2004.05.007DOI Listing
July 2004

Receptor activator of nuclear factor kappaB ligand (RANKL)/osteoprotegerin (OPG) ratio is increased in severe osteolysis.

Am J Pathol 2003 Nov;163(5):2021-31

Laboratoire de Physiopathologie de la Résorption Osseuse et Thérapie des Tumeurs Osseuses Primitives, Faculté de Médecine, Centre Hospitalier Universitaire, 1 rue Gaston Veil, 44035 Nantes Cedex, France.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1892410PMC
http://dx.doi.org/10.1016/s0002-9440(10)63560-2DOI Listing
November 2003

Recent advances in TGF-beta effects on chondrocyte metabolism. Potential therapeutic roles of TGF-beta in cartilage disorders.

Cytokine Growth Factor Rev 2002 Jun;13(3):241-57

Laboratoire de Physiopathologie de la Résorption Osseuse EE 99-01, Faculté de Médecine, University of Nantes, 1 rue Gaston Veil, 44035 Nantes, France.

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June 2002