Publications by authors named "Francoise Pflumio"

59Publications

Ultra-high dose rate FLASH and conventional dose rate irradiation differentially affect human acute lymphoblastic leukemia and normal hematopoiesis.

Int J Radiat Oncol Biol Phys 2020 Oct 16. Epub 2020 Oct 16.

Team Niche and Cancer in Hematopoiesis, U1274, Inserm, 18 route du Panorama, 92260 Fontenay-aux-Roses, France; Laboratoire des cellules Souches Hématopoïétiques et des Leucémies, Service Cellules Souches et Radiations, iRCM/IBFJ/DRF, CEA, F-92260 Fontenay-aux-Roses, France; UMRE008 Stabilité Génétique, Cellules Souches et Radiations, Université de Paris and Université Paris-Saclay, U1274 Inserm, iRCM/IBFJ CEA, F-92265, Fontenay-aux-Roses, France.

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http://dx.doi.org/10.1016/j.ijrobp.2020.10.012DOI Listing
October 2020

Hypoxia Regulates Lymphoid Development of Human Hematopoietic Progenitors.

Cell Rep 2019 11;29(8):2307-2320.e6

UMR Stabilité Génétique Cellules Souches et Radiations, Université de Paris-Saclay, CEA, 18 route du Panorama, 92260 Fontenay-aux-Roses, France; UMR Stabilité Génétique Cellules Souches et Radiations, Université de Paris, CEA, 18 route du Panorama, 92260 Fontenay-aux-Roses, France; Team Niche and Cancer in Hematopoiesis, U1274, Inserm, 18 route du Panorama, 92260 Fontenay-aux-Roses, France; Laboratory of Hematopoietic Stem Cells and Leukemia/Service Stem Cells and Radiation /iRCM/JACOB/DRF, CEA, 18 route du Panorama, 92260 Fontenay-aux-Roses, France. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.10.050DOI Listing
November 2019

Frontline Science: Exhaustion and senescence marker profiles on human T cells in BRGSF-A2 humanized mice resemble those in human samples.

J Leukoc Biol 2020 01 4;107(1):27-42. Epub 2019 Aug 4.

IDMIT Department, CEA-Université Paris Sud 11-INSERM U1184, Immunology of Viral Infections and Autoimmune Diseases, IBFJ, F-92265, Paris, France.

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http://dx.doi.org/10.1002/JLB.5HI1018-410RRDOI Listing
January 2020

Desperately seeking a home marrow niche for T-cell acute lymphoblastic leukaemia.

Adv Biol Regul 2019 12 27;74:100640. Epub 2019 Jul 27.

UMRE008 Stabilité Génétique Cellules Souches et Radiations, U1274 Inserm, Université de Paris, Université Paris-Saclay, CEA, F-92260 Fontenay-aux-Roses, France; Laboratory of Hematopoietic Stem Cells and Leukemia, Team Niche and Cancer in Hematopoiesis, U1274, Inserm, CEA, 18 route du panorama, 92260, Fontenay-aux-Roses, France; Laboratoire labellisé par l'Association pour la Recherche sur le Cancer, France. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22124926193006
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http://dx.doi.org/10.1016/j.jbior.2019.100640DOI Listing
December 2019

Epigenetic Silencing Affects l-Asparaginase Sensitivity and Predicts Outcome in T-ALL.

Clin Cancer Res 2019 04 18;25(8):2483-2493. Epub 2019 Jan 18.

Université Paris Descartes Sorbonne Cité, Institut Necker-Enfants Malades (INEM), Institut National de recherche Médicale (INSERM) U1151, and Laboratory of Onco-Hematology, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Necker Enfants-Malades, Paris, France.

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http://dx.doi.org/10.1158/1078-0432.CCR-18-1844DOI Listing
April 2019

Bone marrow sites differently imprint dormancy and chemoresistance to T-cell acute lymphoblastic leukemia.

Blood Adv 2017 Sep 8;1(20):1760-1772. Epub 2017 Sep 8.

Laboratoire de Recherche sur les Cellules Souches Hématopoïétiques et Leucémiques, Equipe Labellisée Ligue Nationale contre le Cancer, Institut de Radiobiologie Cellulaire et Moléculaire, Commissariat à l'énergie Atomique et aux Energies Alternatives (CEA), Fontenay-aux-Roses, France.

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http://dx.doi.org/10.1182/bloodadvances.2017004960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5728329PMC
September 2017

Homeobox protein TLX3 activates miR-125b expression to promote T-cell acute lymphoblastic leukemia.

Blood Adv 2017 May 4;1(12):733-747. Epub 2017 May 4.

Commissariat à l'Energie Atomique et aux Energies Alternatives, Institut de Radiobiologie Cellulaire et Moléculaire, Laboratoire des Cellules Souches Hématopoïétiques et Leucémiques, Equipe Labellisée Ligue Contre le Cancer, Unité Mixte de Recherche (UMR) 967 Stabilité génomique, cellules souches et radiations, Fontenay-aux-Roses, France.

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http://dx.doi.org/10.1182/bloodadvances.2017005538DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5728055PMC
May 2017

Bone marrow hematons: An access point to the human hematopoietic niche.

Am J Hematol 2017 Oct 29;92(10):1020-1031. Epub 2017 Jul 29.

CHU Clermont-Ferrand, Hôpital Estaing, Hématologie Biologique, 1 place Lucie et Raymond Aubrac, Clermont-Ferrand Cedex 1, 63003, France.

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http://dx.doi.org/10.1002/ajh.24830DOI Listing
October 2017

Triggering the TCR Developmental Checkpoint Activates a Therapeutically Targetable Tumor Suppressive Pathway in T-cell Leukemia.

Cancer Discov 2016 09 28;6(9):972-85. Epub 2016 Jun 28.

Université Paris Descartes Sorbonne Cité, Institut Necker-Enfants Malades (INEM), Institut national de recherche médicale (INSERM) U1151, and Laboratory of Onco-Hematology, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Necker Enfants-Malades, Paris, France.

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http://dx.doi.org/10.1158/2159-8290.CD-15-0675DOI Listing
September 2016

UTX inhibition as selective epigenetic therapy against TAL1-driven T-cell acute lymphoblastic leukemia.

Genes Dev 2016 Mar;30(5):508-21

The Sprott Center for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, Ontario K1H 8L6, Canada; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario K1H 8L6, Canada; Ottawa Institute for Systems Biology, Ottawa, Ontario K1H 8L6, Canada;

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http://dx.doi.org/10.1101/gad.276790.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782046PMC
March 2016

The SCL/TAL1 Transcription Factor Represses the Stress Protein DDiT4/REDD1 in Human Hematopoietic Stem/Progenitor Cells.

Stem Cells 2015 Jul 25;33(7):2268-79. Epub 2015 May 25.

CEA, DSV-IRCM-SCSR-LSHL, UMR 967, équipe labellisée Ligue Nationale contre le Cancer, Fontenay-aux-Roses, Paris, France.

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http://dx.doi.org/10.1002/stem.2028DOI Listing
July 2015

A systems biology approach for defining the molecular framework of the hematopoietic stem cell niche.

Cell Stem Cell 2014 Sep 17;15(3):376-391. Epub 2014 Jul 17.

Sorbonne Universités, UPMC Paris 06, IBPS, UMR 7622, Laboratoire de Biologie du Développement, 75005 Paris; CNRS, INSERM U1156, IBPS, UMR 7622, Laboratoire de Biologie du Développement, 75005 Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2014.06.005DOI Listing
September 2014

Interleukin-18 produced by bone marrow-derived stromal cells supports T-cell acute leukaemia progression.

EMBO Mol Med 2014 Jun 6;6(6):821-34. Epub 2014 Apr 6.

Commissariat à l'Energie Atomique et aux Energies Alternatives (CEA) DSV-IRCM-SCSR-LSHL Equipe Labellisée Ligue Contre le Cancer UMR 967, Fontenay-aux-Roses, France INSERM U967, Fontenay-aux-Roses, France Université Paris Diderot Sorbonne Paris Cité UMR 967, Fontenay-aux-Roses, France Université Paris-Sud UMR 967, Fontenay-aux-Roses, France

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http://dx.doi.org/10.1002/emmm.201303286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203358PMC
June 2014

Assessment of human multi-potent hematopoietic stem/progenitor cell potential using a single in vitro screening system.

PLoS One 2012 28;7(11):e50495. Epub 2012 Nov 28.

CEA, Laboratoire des Cellules Souches Hématopoïétiques et Leucémiques, Institut de Radiobiologie Cellulaire et Moléculaire (IRCM), Fontenay-aux-Roses, France.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0050495PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509091PMC
May 2013

[Novel ETO2-GLIS2 fusion and therapeutic strategy in acute megakaryoblastic leukemia].

Med Sci (Paris) 2012 Nov 12;28(11):1013-6. Epub 2012 Nov 12.

Université Paris Diderot, Paris, France.

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http://dx.doi.org/10.1051/medsci/20122811025DOI Listing
November 2012

Impaired functionality and homing of Fancg-deficient hematopoietic stem cells.

Hum Mol Genet 2012 Jan 3;21(1):121-35. Epub 2011 Oct 3.

Laboratoire de Gamétogenèse Apoptose et Génotoxicite, Institut de Radiobiologie Cellulaire et Moléculaire, Direction des Sciences du Vivant, Commissariat à l'Energie Atomique et aux Energies Alternatives, Fontenay-aux-Roses 92265, France.

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http://dx.doi.org/10.1093/hmg/ddr447DOI Listing
January 2012

Clonal selection in xenografted human T cell acute lymphoblastic leukemia recapitulates gain of malignancy at relapse.

J Exp Med 2011 Apr 4;208(4):653-61. Epub 2011 Apr 4.

Laboratoire de Recherche sur les Cellules Souches Hématopoïétiques et Leucémiques, Institut de Radiobiologie Cellulaire et Moléculaire, Commissariat à l'Energie Atomique et aux Energies Alternatives, 92265 Fontenay-aux-Roses, France.

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http://dx.doi.org/10.1084/jem.20110105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135355PMC
April 2011

Alternative lengthening of telomeres in human glioma stem cells.

Stem Cells 2011 Mar;29(3):440-51

Laboratoire de RadioPathologie, Institut de Radiobiologie Cellulaire et Moléculaire, CEA, Fontenay-aux-Roses, France.

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http://dx.doi.org/10.1002/stem.600DOI Listing
March 2011

[How a suppressor of tumor gets hooked of the leukaemic proliferation in man].

Med Sci (Paris) 2011 Feb 8;27(2):142-3. Epub 2011 Mar 8.

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http://dx.doi.org/10.1051/medsci/2011272142DOI Listing
February 2011

NKX3.1 is a direct TAL1 target gene that mediates proliferation of TAL1-expressing human T cell acute lymphoblastic leukemia.

J Exp Med 2010 Sep 20;207(10):2141-56. Epub 2010 Sep 20.

Laboratoire de recherche sur la Réparation et la Transcription dans les cellules Souches, Direction des Sciences du Vivant, Commissariat à l'Energie Atomique et aux Energies Alternatives, 92265 Fontenay-aux-Roses, France.

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http://dx.doi.org/10.1084/jem.20100745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947082PMC
September 2010

[Demonstration of leukemic stem cells in the human T-ALLs and study of the involvement of the NOTCH, TAL1 and ERK/MAPK pathways in human T-leukemogenesis].

Ann Pathol 2008 Nov 17;28 Spec No 1(1):S28-9. Epub 2008 Oct 17.

Laboratoire des cellules souches hématopoïétiques et leucémiques, institut de radiobiologie moléculaire et cellulaire, CEA, 18, route de Panorama, BP 6, 92265 Fontenay-aux-Roses, France.

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http://dx.doi.org/10.1016/j.annpat.2008.09.004DOI Listing
November 2008

NOTCH is a key regulator of human T-cell acute leukemia initiating cell activity.

Blood 2009 Feb 4;113(8):1730-40. Epub 2008 Nov 4.

Institut Cochin, Université Paris Descartes, Centre National de la Recherche Scientifique, Unite Mixte de Recherche 8104 Paris, France.

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http://dx.doi.org/10.1182/blood-2008-02-138172DOI Listing
February 2009

The HOXB4 homeoprotein differentially promotes ex vivo expansion of early human lymphoid progenitors.

Stem Cells 2008 Feb 25;26(2):312-22. Epub 2007 Oct 25.

Institut Cochin, Département d'Hématologie, Paris, France.

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http://dx.doi.org/10.1634/stemcells.2007-0721DOI Listing
February 2008

CD4 regulation in human lymphoid non-T-cells: a role for the silencer element.

Mol Immunol 2007 Jan 21;44(4):267-75. Epub 2006 Apr 21.

Université Pierre et Marie Curie/CNRS UMR 7087, Groupe Hospitalier Pitié-Salpêtrière, 83 Boulevard de l'Hôpital, 75651 Paris cedex 13, France.

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http://dx.doi.org/10.1016/j.molimm.2006.03.002DOI Listing
January 2007

Dynamics of thymus-colonizing cells during human development.

Immunity 2006 Feb;24(2):217-30

Laboratoire d'Immunologie Cellulaire et Immunopathologie de l'Ecole Pratique des Hautes Etudes and UMR 7151, Centre National de la Recherche Scientifique, Université Paris 7, Paris, France.

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http://dx.doi.org/10.1016/j.immuni.2006.01.008DOI Listing
February 2006

SCL/TAL1 expression level regulates human hematopoietic stem cell self-renewal and engraftment.

Blood 2005 Oct 16;106(7):2318-28. Epub 2005 Jun 16.

Department of Hematology, Institut Cochin, U567 Institut National de la Santé et de la Recherche Médicale (INSERM), Centre National de la Recherche Scientifique (CNRS) UMR 8104, Paris, France.

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http://www.bloodjournal.org/content/106/7/2318.full.pdf
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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2005-02-05
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http://dx.doi.org/10.1182/blood-2005-02-0557DOI Listing
October 2005

Molecular characterization of early human T/NK and B-lymphoid progenitor cells in umbilical cord blood.

Blood 2004 Dec 26;104(13):3918-26. Epub 2004 Aug 26.

EMI-0013 Institut National de la Santé et de la Recherche Médicale-Université Paris 7, Laboratoire d'Immunologie Cellulaire et Immunopathologie de l'EcolePratique des Hauntes Etudes, Hôpital Saint-Louis, 75475 Paris CEDEX 10, France.

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http://dx.doi.org/10.1182/blood-2004-05-1845DOI Listing
December 2004

Human CD34+ cells differentiate into microglia and express recombinant therapeutic protein.

Proc Natl Acad Sci U S A 2004 Mar 27;101(10):3557-62. Epub 2004 Feb 27.

Institut National de la Santé et de la Recherche Médicale U561, Hôpital Saint-Vincent de Paul, 75014 Paris, France.

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http://dx.doi.org/10.1073/pnas.0306431101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC373501PMC
March 2004

Ex vivo expansion of human hematopoietic stem cells by direct delivery of the HOXB4 homeoprotein.

Nat Med 2003 Nov 26;9(11):1423-7. Epub 2003 Oct 26.

Institut Cochin, Département d'Hématologie, INSERM U567, CNRS UMR 8104, Université Paris 5, Maternité Port-Royal, 123, Bd de Port-Royal, 75014 Paris, France.

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http://dx.doi.org/10.1038/nm953DOI Listing
November 2003

Maximal lentivirus-mediated gene transfer and sustained transgene expression in human hematopoietic primitive cells and their progeny.

Mol Ther 2002 Nov;6(5):673-7

Institut Cochin, INSERM U567, CNRS UMR 8104, Hematology Department, Maternité de Port-Royal, Paris, France.

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November 2002