Francois Ghiringhelli

Francois Ghiringhelli

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Francois Ghiringhelli

Publications by authors named "Francois Ghiringhelli"

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Implementation and use of whole exome sequencing for metastatic solid cancer.

EBioMedicine 2020 Jan 7;51:102624. Epub 2020 Jan 7.

Department of Medical Oncology, Georges François Leclerc Cancer Center - UNICANCER, 1 rue Professeur Marion, Dijon 21000, France; Platform of Transfer in Cancer Biology, Georges François Leclerc Cancer Center - UNICANCER, Dijon, France; Université Bourgogne Franche-Comté, Dijon, France; Genomic and Immunotherapy Medical Institute, Dijon, France; INSERM U1231, Dijon, France. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2019.102624DOI Listing
January 2020

Efficacy of immune checkpoint inhibitors in older patients with non-small cell lung cancer: Real-world data from multicentric cohorts in Canada and France.

J Geriatr Oncol 2020 Jan 13. Epub 2020 Jan 13.

Centre de recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Division of Oncology, Department of Medicine Montréal, QC, Canada; Centre Hospitalier de l'Université de Montréal (CHUM), Hematology-Oncology Division, Department of Medicine, Montréal, QC, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jgo.2020.01.002DOI Listing
January 2020

Platinum Derivatives Effects on Anticancer Immune Response.

Biomolecules 2019 Dec 20;10(1). Epub 2019 Dec 20.

Platform of Transfer in Cancer Biology, Centre Georges-François Leclerc, F-21000 Dijon, France.

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http://dx.doi.org/10.3390/biom10010013DOI Listing
December 2019

Immune Th17 lymphocytes play a critical role in the multiple beneficial properties of resveratrol.

Food Chem Toxicol 2019 Dec 26;137:111091. Epub 2019 Dec 26.

University of Bourgogne-Franche Comté, F-21000, Dijon, France; INSERM Research Center U1231 - Cancer and Adaptive Immune Response Team, Dijon, F-21000, France; INSERM U1231 "Lipids, Nutrition, Cancer", F-21000, Dijon, France.

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http://dx.doi.org/10.1016/j.fct.2019.111091DOI Listing
December 2019

Prognostic value of transcriptomic determination of tumour-infiltrating lymphocytes in localised breast cancer.

Eur J Cancer 2019 Oct 6;120:97-106. Epub 2019 Sep 6.

Platform of Transfer in Biology of Cancer, Georges Francois Leclerc Cancer Center, 1 Rue Du Professeur Marion, 21000 Dijon, France; GIMI Genetic and Immunology Medical Institute, 21000 Dijon, France; Department of Medical Oncology, Georges Francois Leclerc Cancer Center, 1 Rue Du Professeur Marion, 21000 Dijon, France; INSERM U1231, Dijon, France; Univ. Bourgogne Franche-Comté, Dijon, France. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2019.07.020DOI Listing
October 2019

[Immunoediting eventually proven in humans. Genetics to assist immunotherapy].

Med Sci (Paris) 2019 Aug-Sep;35(8-9):629-631. Epub 2019 Sep 18.

Centre Georges François Leclerc, Inserm UMR 1231, 1, rue du Pr Marion, 21000 Dijon, France.

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http://dx.doi.org/10.1051/medsci/2019125DOI Listing
September 2019

[Combinations of chemotherapy or radiotherapy with checkpoint inhibitors].

Biol Aujourdhui 2018 11;212(3-4):77-79. Epub 2019 Apr 11.

Université de Bourgogne Franche-Comté, Dijon, France - Centre Georges-François Leclerc, Département d'Oncologie Médicale, 1 rue Pr Marion, BP77980, 21079 Dijon, France - INSERM LNC U1231, Dijon, France.

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http://dx.doi.org/10.1051/jbio/2019004DOI Listing
August 2019

Is There a Place for Immunotherapy for Metastatic Microsatellite Stable Colorectal Cancer?

Front Immunol 2019 6;10:1816. Epub 2019 Aug 6.

Department of Medical Oncology, Centre Georges François Leclerc, Dijon, France.

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http://dx.doi.org/10.3389/fimmu.2019.01816DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691024PMC
August 2019

STAT3, a Master Regulator of Anti-Tumor Immune Response.

Cancers (Basel) 2019 Aug 30;11(9). Epub 2019 Aug 30.

Platform of Transfer in Cancer Biology, Centre Georges François Leclerc, INSERM LNC UMR1231,University of Bourgogne Franche-Comté, F-21000 Dijon, France.

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http://dx.doi.org/10.3390/cancers11091280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770459PMC
August 2019

Cancer cells induce immune escape via glycocalyx changes controlled by the telomeric protein TRF2.

EMBO J 2019 06 18;38(11). Epub 2019 Apr 18.

Université Côte d'Azur, Centre National de la Recherche Scientifique (CNRS) UMR7284, Institut National de la Santé et de la Recherche Médicale (INSERM) U1081, Institute for Research on Cancer and Aging, Nice (IRCAN), Nice, France

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http://dx.doi.org/10.15252/embj.2018100012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6545744PMC
June 2019

Optimized fractionated radiotherapy with anti-PD-L1 and anti-TIGIT: a promising new combination.

J Immunother Cancer 2019 Jun 25;7(1):160. Epub 2019 Jun 25.

Department of Radiation Oncology, Unicancer - Georges-Francois Leclerc Cancer Center, 1 rue Professeur Marion 77 980, 21079, Dijon Cedex, BP, France.

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http://dx.doi.org/10.1186/s40425-019-0634-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593525PMC
June 2019

Transcriptional Programs Underlying Cd4 T Cell Differentiation and Functions.

Int Rev Cell Mol Biol 2018 20;341:1-61. Epub 2018 Aug 20.

Centre de Recherche INSERM LNC-UMR1231, Dijon, France; Univ. Bourgogne Franche-Comté, Dijon, France; Platform of Transfer in Cancer Biology, Centre Georges-François Leclerc, Dijon, France.

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https://linkinghub.elsevier.com/retrieve/pii/S19376448183007
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http://dx.doi.org/10.1016/bs.ircmb.2018.07.002DOI Listing
April 2019

Therapeutic drug monitoring as a tool to optimize 5-FU-based chemotherapy in gastrointestinal cancer patients older than 75 years.

Eur J Cancer 2019 Apr 5;111:116-125. Epub 2019 Mar 5.

Pharmacy Department, Centre Georges-François Leclerc, 1 rue Pr. Marion, 21000 Dijon, France; INSERM U1231, University of Burgundy Franche-Comté, 7 Bd Jeanne d'Arc, 21000 Dijon, France. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2019.01.102DOI Listing
April 2019

Cell lines and immune classification of glioblastoma define patient's prognosis.

Br J Cancer 2019 04 22;120(8):806-814. Epub 2019 Mar 22.

Research Platform in Biological Oncology, Dijon, France.

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http://dx.doi.org/10.1038/s41416-019-0404-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474266PMC
April 2019

Deciphering the Roles of Innate Lymphoid Cells in Cancer.

Front Immunol 2019 3;10:656. Epub 2019 Apr 3.

INSERM UMR1231, Dijon, France.

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http://dx.doi.org/10.3389/fimmu.2019.00656DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462996PMC
April 2019

The Role of Molecular Profiling to Predict the Response to Immune Checkpoint Inhibitors in Lung Cancer.

Cancers (Basel) 2019 Feb 10;11(2). Epub 2019 Feb 10.

Department of Medical Oncology. Centre Georges-François Leclerc, 21000 Dijon, France.

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http://www.mdpi.com/2072-6694/11/2/201
Publisher Site
http://dx.doi.org/10.3390/cancers11020201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406957PMC
February 2019

Nouvelles stratégies innovantes en immunothérapie.

Bull Cancer 2018 Dec;105 Suppl 1:S101-S112

Université de Bourgogne Franche-Comté, 21000 Dijon, France; Centre Georges-François-Leclerc, département d'oncologie médicale, 1, rue du Professeur-Marion, 21000 Dijon, France; Inserm LNC U1231, 21000 Dijon, France. Electronic address:

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http://dx.doi.org/10.1016/S0007-4551(18)30395-3DOI Listing
December 2018

Genomic biomarker of checkpoint efficacy, highways for precision medicine in lung cancer.

Oncotarget 2018 Nov 27;9(93):36547-36548. Epub 2018 Nov 27.

Francois Ghiringhelli: Platform of Transfer in Cancer Biology, Georges François Leclerc Cancer Center, UNICANCER, Dijon, France; Univ. Bourgogne Franche-Comté, Dijon, France; Georges François Leclerc Cancer Center - UNICANCER, Dijon, France; INSERM U1231, Dijon, France; Genetic and Immunology Medical Institute, Dijon, France.

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http://www.oncotarget.com/fulltext/26389
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http://dx.doi.org/10.18632/oncotarget.26389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290964PMC
November 2018

Regulation of T cell antitumor immune response by tumor induced metabolic stress.

Cell Stress 2018 Nov 27;3(1):9-18. Epub 2018 Nov 27.

Cancer Biology Research Platform, Centre Georges-François Leclerc, Dijon, France.

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http://dx.doi.org/10.15698/cst2019.01.171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6551678PMC
November 2018

Bevacizumab-based Chemotherapy for Poorly-differentiated Neuroendocrine Tumors.

Anticancer Res 2018 Oct;38(10):5963-5968

University of Bourgogne Franche-Comté, Dijon, France

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http://dx.doi.org/10.21873/anticanres.12943DOI Listing
October 2018

Reply to M. Mo et al.

J Clin Oncol 2018 08 4;36(23):2452-2453. Epub 2018 Jun 4.

Thomas Aparicio, Saint Louis Hospital, Assistance Publique-Hôpitaux de Paris, and Université Paris 7, Sorbonne Paris-Cité, Paris Diderot University, Paris, France; Francois Ghiringhelli, Centre Georges-François Leclerc, Dijon, France; Valerie Boige, Gustave Roussy, Villejuif, France; Karine Le Malicot, Fédération Francophone de Cancérologie Digestive, Dijon, France; Julien Taieb, Sorbonne Paris-Cité, Paris Descartes University, and Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, Paris, France; and Jaafar Bennouna, Centre Hospitalier Universitaire Nantes, Nantes, France.

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http://dx.doi.org/10.1200/JCO.2018.78.9669DOI Listing
August 2018

Docetaxel, cisplatin, and fluorouracil chemotherapy for metastatic or unresectable locally recurrent anal squamous cell carcinoma (Epitopes-HPV02): a multicentre, single-arm, phase 2 study.

Lancet Oncol 2018 08 2;19(8):1094-1106. Epub 2018 Jul 2.

Department of Oncology, University Hospital of Besancon, Centre Hospitalier Universitaire de Besançon, Besançon, France; Department of Oncology and Radiotherapy, Hôpital Nord Franche Comté, Montbéliard, France; Clinical Investigational Center, CIC-1431, University Hospital of Besançon, Besançon, France; INSERM, Unit 1098, University of Bourgogne Franche-Comté, Besançon, France; Groupe Coopérateur Multidisciplinaire en Oncologie (GERCOR) Oncology Multidisciplinary Group, Paris, France; Fédération Francophone de Cancérologie Digestive (FFCD), Dijon, France.

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http://dx.doi.org/10.1016/S1470-2045(18)30321-8DOI Listing
August 2018

Three Versus 6 Months of Oxaliplatin-Based Adjuvant Chemotherapy for Patients With Stage III Colon Cancer: Disease-Free Survival Results From a Randomized, Open-Label, International Duration Evaluation of Adjuvant (IDEA) France, Phase III Trial.

J Clin Oncol 2018 05 5;36(15):1469-1477. Epub 2018 Apr 5.

Thierry André and Benoist Chibaudel, Hôpital Saint-Antoine, Assistance Publique-Hôpitaux de Paris; Thierry André, Sorbonne Universités, UMPC Paris 06; Marine Hug de Larauze and Benoist Chibaudel and Thierry André, Groupe Coopérateur Multidisciplinaire en Oncologie (GERCOR); Christophe Louvet, Institut Mutualiste Montsouris; Céline Lepère, Hôpital Européen Georges Pompidou (HEGP); Gaël Deplanque, Groupe Hospitalier Saint-Joseph; Jean-Baptiste Bachet, Groupe Hospitalier Pitié Salpêtrière and Sorbonne Université, UMPC Paris 06; Ahmed Khalil, Hôpital Tenon; Julien Taieb, Hôpital Européen Georges Pompidou and Sorbonne Paris Cité, Université Paris Descartes, Paris; Julien Taieb, Fédération Française de Cancérologie Digestive; Jeremie Bez, Fédération Française de Cancérologie Digestive; François Ghiringhelli, Centre Georges-François Leclerc, Dijon; Dewi Vernerey and Sophie Paget-Bailly, CHU de Besançon; Serge Fratte, Hôpital de Besançon; Sophie Paget-Bailly, Franck Bonnetain and Dewi Vernerey INSERM UMR1098, Besançon; Laurent Mineur, Institut Sainte Catherine, Avignon; Jaafar Bennouna, Institut de Cancérologie de l'Ouest René Gauducheau, Saint-Herblain et Institut de Cancérologie Paul Papin, Angers; Jérôme Desrame, Hôpital Jean Mermoz, Lyon; Roger Faroux, Centre Hospitalier Départemental de La Roche sur Yon, La Roche sur Yon; Serge Fratte, Hôpital of Belfort-Montbeliard, Montbeliard; Jérôme Dauba, Centre Hospitalier Layné, Mont-de-Marsan; Olivier Dupuis, Clinique Victor Hugo, Le Mans; Yves Becouran, Institut Bergonié, Bordeaux; May Mabro, Hôpital Foch, Suresnes; Joëlle Egreteau, Centre Hospitalier de Bretagne Sud Site de Lorient, Lorient; Olivier Bouche, Hôpital Robert Debré, Reims; Marc Ychou, Institut du Cancer de Montpellier, and CHU de Montpellier, Montpellier; Marie Pierre Galais, Centre Francois Baclesse, Caen; Louis Marie Dourthe, Clinique Sainte Anne, Strasbourg; and Aimery de Gramont, Institut Hospitalier Franco-Britannique, Levallois-Perret, France.

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http://ascopubs.org/doi/10.1200/JCO.2017.76.0355
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http://dx.doi.org/10.1200/JCO.2017.76.0355DOI Listing
May 2018

amplification induces sensitivity to anti therapy in pancreatic acinar cell carcinoma.

World J Gastrointest Oncol 2018 Apr;10(4):103-107

Platform of Transfer in Oncology, Center GF Leclerc, Dijon 21000, France.

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http://dx.doi.org/10.4251/wjgo.v10.i4.103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5900454PMC
April 2018

WITHDRAWN: Nouvelles stratégies innovantes en immunothérapie.

Bull Cancer 2018 Apr 26. Epub 2018 Apr 26.

Université de Bourgogne Franche-Comté, 21000 Dijon, France; Centre Georges-François-Leclerc, département d'oncologie médicale, 1, rue du Professeur-Marion, 21000 Dijon, France; Inserm LNC U1231, 21000 Dijon, France. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00074551183011
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http://dx.doi.org/10.1016/j.bulcan.2018.03.004DOI Listing
April 2018

Bevacizumab Maintenance Versus No Maintenance During Chemotherapy-Free Intervals in Metastatic Colorectal Cancer: A Randomized Phase III Trial (PRODIGE 9).

J Clin Oncol 2018 03 18;36(7):674-681. Epub 2018 Jan 18.

Thomas Aparicio, Centre Hospitalier Universitaire (CHU) Saint Louis, Assistance Public Hôpitaux de Paris (APHP), and Université Paris 7, Sorbonne Paris Cité; Julien Taieb, Hôpital Européen Georges Pompidou, Paris; Francois Ghiringhelli, Centre Georges-François Leclerc; Karine Le Malicot, Fédération Francophone de Cancérologie Digestive; Come Lepage, CHU Le Bocage, Institut National de la Santé et de la Recherche Médicale Unité Mixte de Recherche (UMR) 1231, Dijon; Valérie Boige, Institut Gustave Roussy, Villejuif; Olivier Bouché, CHU Robert Debré, Reims; Jean-Marc Phelip, CHU Saint Etienne-Hôpital Nord, Saint Priest en Jarez; Eric François, Centre Antoine Lacassagne, Nice; Christian Borel, Paul Strauss Center, Strasbourg; Roger Faroux, Centre Hospitalier (CH) La Roche sur Yon, La Roche sur Yon; Laetitia Dahan, CHU La Timone, Aix-Marseille-University, Marseille; Stéphane Jacquot, Centre de Cancérologie du Grand Montpellier, Montpellier; Dominique Genet, Accompagnement de la Recherche Clinique Hospitalière (ARCH)/Polyclinique, Limoges; Faiza Khemissa, CH Saint Jean, Perpignan; Etienne Suc, Clinique Saint Jean du Languedoc, Toulouse; Françoise Desseigne, Centre Léon Bérard, Lyon; Patrick Texereau, CH Layne, Mont-De-Marsan; and Jaafar Bennouna, Institut de Cancérologie de l'Ouest, Saint Herblay, France.

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http://dx.doi.org/10.1200/JCO.2017.75.2931DOI Listing
March 2018

The Balance Between Cytotoxic T-cell Lymphocytes and Immune Checkpoint Expression in the Prognosis of Colon Tumors.

J Natl Cancer Inst 2018 01;110(1)

Programme "Cartes d'Identité des Tumeurs," Ligue Nationale Contre le Cancer, Paris, France; INSERM, UMRS 938 - Centre de Recherche Saint-Antoine, Equipe "Instabilité des Microsatellites et Cancers," Equipe labellisée par la Ligue Nationale contre le Cancer, Paris, France; Sorbonne Université, UPMC Univ Paris 06, Paris, France; AP-HP, Hôpital Saint-Antoine, Service d'Anatomie et Cytologie Pathologiques, Paris, France; Centre de Recherche en Cancérologie de Toulouse, UMR 1037 INSERM - Université Toulouse III, Department of Pathology, CHU, Toulouse, France; Laboratoire d'Oncopharmacologie, EA 3836, Centre Antoine Lacassagne, Nice, France; INSERM, U682, Développement et Physiopathologie de l'Intestin et du Pancréas, Strasbourg, France; AP-HP, Hôpital Saint-Antoine, Service d'Oncologie Médicale, Paris, France; AP-HP, Laboratoire d'oncogénétique et d'Angiogénétique, GH Pitié-Salpétrière, Paris, France; INSERM, Unité Mixte de Recherche, Paris Sorbonne Cité, Université Paris Descartes, Paris, France; Aix Marseille Univ, INSERM, GMGF, Marseille, France and RGDS, HP Clairval, Marseille, France; AP-HP, Service de Chirurgie Générale et Digestive, Hôpital Saint-Antoine, Paris, France; Department of Oncologic Medicine, Gustave-Roussy, Villejuif, France; Université Paris Descartes, Paris Sorbonne Cité INSERM UMR-S775, Paris, France; INSERM, Burgundy Cancer Registry, U866, Burgundy University, Dijon University Hospital, BP 87900?21079 Dijon, France; Department of Medical Oncology, Centre Georges-François Leclerc, Dijon, France; INSERM, UMR866, Burgundy University; Platform of transfer in oncology, Burgundy University, Centre Georges-François Leclerc, Dijon, France.

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http://dx.doi.org/10.1093/jnci/djx136DOI Listing
January 2018

Dynamic evaluation of circulating tumour cells in patients with advanced gastric and oesogastric junction adenocarcinoma: Prognostic value and early assessment of therapeutic effects.

Eur J Cancer 2017 07 26;79:15-22. Epub 2017 Apr 26.

INSERM U970 - PARCC (Paris Cardiovascular Research Center), Paris Descartes University, Sorbonne Paris Cité, Paris, France; Hôpital Européen Georges-Pompidou, APHP, Department of GI Oncology, Paris Descartes University, Sorbonne Paris Cité, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2017.03.036DOI Listing
July 2017

Precision medicine in breast cancer: reality or utopia?

J Transl Med 2017 06 17;15(1):139. Epub 2017 Jun 17.

Département d'Oncologie Médicale, Centre Georges-François-Leclerc, 21000, Dijon, France.

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http://dx.doi.org/10.1186/s12967-017-1239-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474301PMC
June 2017

Sirtuin-1 Activation Controls Tumor Growth by Impeding Th17 Differentiation via STAT3 Deacetylation.

Cell Rep 2017 04;19(4):746-759

University Bourgogne Franche-Comté, LNC UMR866, 21000 Dijon, France; INSERM, LNC UMR866, 21000 Dijon, France; Platform of Transfer in Oncology, University Bourgogne Franche-Comté, Centre Georges François Leclerc, 21000 Dijon, France; Department of Medical Oncology, Centre Georges François Leclerc, 21000 Dijon, France. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.04.004DOI Listing
April 2017

Alteration in Taste Perception in Cancer: Causes and Strategies of Treatment.

Front Physiol 2017 8;8:134. Epub 2017 Mar 8.

Physiologie de la Nutrition and Toxicologie, UMR U866 Institut National de la Santé et de la Recherche Médicale/Université de Bourgogne-Franche Compté/Agro-Sup Dijon, France.

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http://dx.doi.org/10.3389/fphys.2017.00134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340755PMC
March 2017

[The anti-tumor immune response in breast cancer: Update and therapeutic perspectives].

Ann Pathol 2017 Feb 31;37(1):133-141. Epub 2017 Jan 31.

Département d'oncologie médicale, centre Georges-François-Leclerc, 21000 Dijon, France; Plateforme de transfert en biologie cancérologique, centre Georges-François-Leclerc, 21000 Dijon, France; UMR Inserm U866, faculté de médecine de Dijon, 21000 Dijon, France; UFR des sciences de santé, 21000 Dijon, France; Université de Bourgogne, 21000 Dijon, France.

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http://dx.doi.org/10.1016/j.annpat.2016.12.012DOI Listing
February 2017

T9 cells in anti-tumor immunity.

Semin Immunopathol 2017 01 10;39(1):39-46. Epub 2016 Nov 10.

INSERM, U866,, Dijon, France.

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http://dx.doi.org/10.1007/s00281-016-0599-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5222918PMC
January 2017

Efficiency of olaparib in colorectal cancer patients with an alteration of the homologous repair protein.

World J Gastroenterol 2016 Dec;22(48):10680-10686

Francois Ghiringhelli, Department of Medical Oncology, Center GF Leclerc, 21000 Dijon, France.

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http://dx.doi.org/10.3748/wjg.v22.i48.10680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192280PMC
December 2016

Folfirinox in elderly patients with pancreatic or colorectal cancer-tolerance and efficacy.

World J Gastroenterol 2016 Nov;22(42):9378-9386

Jean-Florian Guion-Dusserre, Aurélie Bertaut, François Ghiringhelli, Julie Vincent, Valérie Quipourt, Sophie Marilier, Zoé Tharin, Leila Bengrine-Lefevre, Department of Medical Oncology, Centre Georges-François Leclerc, 21000 Dijon, France.

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http://dx.doi.org/10.3748/wjg.v22.i42.9378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5107701PMC
November 2016

Obesity As a Risk Factor for Anthracyclines and Trastuzumab Cardiotoxicity in Breast Cancer: A Systematic Review and Meta-Analysis.

J Clin Oncol 2016 09 25;34(26):3157-65. Epub 2016 Jul 25.

Charles Guenancia, Annick Lefebvre, and Yves Cottin, University Hospital; Charles Guenancia, Marianne Zeller, Luc Rochette, Yves Cottin, and Catherine Vergely, Institut National de la Santé et de la Recherche Médicale, U866, Laboratoire de Physiopathologie et Pharmacologie Cardio-Métaboliques; Sylvain Ladoire and François Ghiringhelli, Georges François Leclerc Cancer Center; Sylvain Ladoire and François Ghiringhelli, Institut National de la Santé et de la Recherche Médicale, CRI-866, University of Burgundy, Dijon; Annick Lefebvre, University Hospital, Reims, France; Daniela Cardinale, European Institute of Oncology, Milan, Italy; and Anthony F. Yu, Memorial Sloan Kettering Cancer Center, New York, NY.

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http://dx.doi.org/10.1200/JCO.2016.67.4846DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5569689PMC
September 2016

Accumulation of MDSC and Th17 Cells in Patients with Metastatic Colorectal Cancer Predicts the Efficacy of a FOLFOX-Bevacizumab Drug Treatment Regimen.

Cancer Res 2016 09 5;76(18):5241-52. Epub 2016 Aug 5.

INSERM, U866, Dijon, France. UFR des Sciences de Santé, Université de Bourgogne-Franche Comté, Dijon, France. Centre Georges François Leclerc, Dijon, France. Plateforme de Transfert en Biologie Cancérologique, CGFL, Dijon, France.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-3164DOI Listing
September 2016

Biomarkers of immunogenic stress in metastases from melanoma patients: Correlations with the immune infiltrate.

Oncoimmunology 2016 Jun 16;5(6):e1160193. Epub 2016 Mar 16.

Equipe 11 labellisée pas la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Paris, France; INSERM, U1138, Paris, France; Université Paris Descartes, Sorbonne Paris Cité, Paris, France; Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus, Villejuif, France; Pôle de Biologie, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, Paris, France; Karolinska Institute, Department of Women's and Children's Health, Karolinska University Hospital, Stockholm, Sweden.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938307PMC
June 2016

[Th9 cells: a new population of helper T cells].

Med Sci (Paris) 2016 Apr 2;32(4):387-93. Epub 2016 May 2.

Centre Georges François Leclerc, 1, rue du Professeur Marion, 21079 Dijon, France - Inserm, U866, faculté de médecine et de pharmacie, 7, boulevard Jeanne d'Arc, 21079 Dijon, France - Université de Bourgogne, faculté de médecine, 7, boulevard Jeanne d'Arc, 21079 Dijon, France.

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http://dx.doi.org/10.1051/medsci/20163204017DOI Listing
April 2016

Restoring Anticancer Immune Response by Targeting Tumor-Derived Exosomes With a HSP70 Peptide Aptamer.

J Natl Cancer Inst 2016 Mar 22;108(3). Epub 2015 Nov 22.

Affiliations of authors:INSERM, UMR 866, Laboratoire d'Excellence LipSTIC , Dijon , France (JG, GM, MC, AMMD, NP, AH, SR, HM, NI, VC, CR, FL, FG, AdT, RS, CG); Faculty of Medicine and Pharmacy, University of Burgundy , Dijon , France (JG, GM, MC, AMMD, NP, AH, SR, HM, NI, VC, CR, FL, FG, AdT, RS, CG); Department of Medical Oncology, Georges-François Leclerc Centre , Dijon , France (JG, NI, CR, AB, VG, FG, PF, CG); Department of Biostatistics, Georges-François Leclerc Centre , Dijon , France (AB); CHU , Dijon , France (FL); Equipe Labellisée par la Ligue Nationale contre le Cancer (CG).

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http://dx.doi.org/10.1093/jnci/djv330DOI Listing
March 2016

Tumor infiltration by Tbet+ effector T cells and CD20+ B cells is associated with survival in gastric cancer patients.

Oncoimmunology 2016 Feb 3;5(2):e1054598. Epub 2015 Jun 3.

Department of Medical Oncology Center Georges François Leclerc; Dijon, France; Faculté des Sciences de Santé; Université de Bourgogne; Dijon, France; Institut National de la Santé et de la Recherche Médicale (INSERM) UMR 866; Dijon, France; Department of Biology and Pathology of Tumors. Plateform of Genetic; Immunology and Histology of Solid Tumors; Centre Georges-François Leclerc; Dijon, France; Faculté des Sciences de Santé; Université de Bourgogne; Dijon, France.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4801425PMC
February 2016

Human ectonucleotidase-expressing CD25 Th17 cells accumulate in breast cancer tumors and exert immunosuppressive functions.

Oncoimmunology 2016;5(1):e1055444. Epub 2015 Jul 6.

UMR866; INSERM; Dijon, France; Faculté de Médecine; Université de Bourgogne; Dijon, France; Department of Medical Oncology; Centre Georges François Leclerc; Dijon, France; LA and FG share senior co-authorship.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760277PMC
July 2015