Francois Cambien

Francois Cambien

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Francois Cambien

Francois Cambien

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Genetic Reduction in Left Ventricular Protein Kinase C-α and Adverse Ventricular Remodeling in Human Subjects.

Circ Genom Precis Med 2018 03;11(3):e001901

From the Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia (R.H., M.P.M., J.B., K.B.M., T.P.C.); Cardiovascular Research Center (N.R.T., V.A.P., P.T.E.) and Center for Human Genetic Research and Cardiovascular Research Center (C.N.-C.), Massachusetts General Hospital, Boston; Department of Statistics, University of Illinois at Urbana-Champaign (S.D.Z.); Heidelberg University Hospital, Germany (B.M., H.A.K.); Department of Genetic Epidemiology, Institute of Human Genetics, University of Münster, Germany (F.R., M.S.); INSERM UMRS1166-IACN, Hôpital Pitié-Salpêtrière, Paris, France (E.V., F.C.); Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, MA (H.L.); Department of Epidemiology, University of Washington, Seattle (N.L.S.); Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, the Netherlands (J.F.F.); Boston University School of Medicine, MA (R.S.V.); Department of Cardiology, University of Groningen, University Medical Center Groningen, the Netherlands (P.v.d.H.); Medical and Population Genetics Program, Broad Institute, Cambridge, MA (C.N.-C.); Center for Applied Genomics, Children's Hospital of Philadelphia, PA (J.L., C.E.K., H.H.); Center for Bioinformatics and Computational Biology, University of Maryland, College Park (S.H.); Stanford Center for Inherited Cardiovascular Disease, Stanford University School of Medicine, CA (E.A.A.); Department of Cardiovascular Medicine, Cleveland Clinic, OH (C.S.M., W.H.W.T.); and Howard Hughes Medical Institute and Cincinnati Children's Hospital Medical Center, OH (M.M., J.D.M.).

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http://dx.doi.org/10.1161/CIRCGEN.117.001901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5858599PMC
March 2018

Role of lipid phosphate phosphatase 3 in human aortic endothelial cell function.

Cardiovasc Res 2016 12 30;112(3):702-713. Epub 2016 Sep 30.

Sorbonne Universités, UPMC, INSERM UMR_S 1166, ICAN, Genomics and Pathophysiology of Cardiovascular Diseases Team, 91 Bd de l'Hôpital, 75013 Paris, France

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http://dx.doi.org/10.1093/cvr/cvw217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5157138PMC
December 2016

Preservation Analysis of Macrophage Gene Coexpression Between Human and Mouse Identifies PARK2 as a Genetically Controlled Master Regulator of Oxidative Phosphorylation in Humans.

G3 (Bethesda) 2016 10 13;6(10):3361-3371. Epub 2016 Oct 13.

Sorbonne Universités, Université Pierre et Marie Curie, Paris 06, Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche en Santé 1166, F-75013 Paris, France Institute for Cardiometabolism and Nutrition, F-75013 Paris, France

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http://dx.doi.org/10.1534/g3.116.033894DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5068955PMC
October 2016

SASH1, a new potential link between smoking and atherosclerosis.

Atherosclerosis 2015 Oct 14;242(2):571-9. Epub 2015 Aug 14.

Sorbonne Universités, UPMC, UMR_S 1166-ICAN, Genomics and Pathophysiology of Cardiovascular Diseases, Institute of Cardiometabolism and Nutrition, ICAN, Pitié-Salpêtrière Hospital, F-75013, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2015.08.013DOI Listing
October 2015

Contribution of Rare and Common Genetic Variants to Plasma Lipid Levels and Carotid Stiffness and Geometry: A Substudy of the Paris Prospective Study 3.

Circ Cardiovasc Genet 2015 Aug 9;8(4):628-36. Epub 2015 Jul 9.

From the Inserm, UMR_S 1166 (C.P., G.E., U.E., F.C.), CNRS UMR 7190 (P.C.), and CNRS, UMR 8256 (Z.L.), Sorbonne Universités, UPMC Univ Paris 06; Inserm, UMR_S 970, Sorbonne Paris Cité (J.-P.E., P.B., M.A., G.E., S.L., X.J.); Department of Cardiology, European Hospital of Georges Pompidou, Université Paris Descartes (N.D.); Centre d'Investigations Préventives et Cliniques (IPC Center), Paris, France (B.P., F.T.); and Inserm, UMR_S 1116; Université de Lorraine, Nancy, France (V.R., P.L.).

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http://dx.doi.org/10.1161/CIRCGENETICS.114.000979DOI Listing
August 2015

Adrenomedullin and arterial stiffness: integrative approach combining monocyte ADM expression, plasma MR-Pro-ADM, and genome-wide association study.

Circ Cardiovasc Genet 2014 Oct 22;7(5):634-41. Epub 2014 Jul 22.

From UMR_S 1166, Sorbonne Universités UPMC Université Paris 06, UMR_S 1166 INSERM, UMR_S 1166 ICAN Institute for Cardiometabolism and Nutrition, Paris, France (F.B., M.G., R.C., G.M., D.-A.T., F.C., L.T.); Department of Cardiology, Caen University Hospital, Caen, France (F.B.); Department of Medicine II (P.S.W., T.M.), Center for Thrombosis and Hemostasis (P.S.W.), Institute for Clinical Chemistry and Laboratory Medicine (K.J.L.), University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany; Department of General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany (T.Z., S.B.); Institut de Cardiologie, Centre Hospitalier Universitaire Pitié-Salpêtriėre (ACTION Group, AP-HP, Université Paris 6), Paris, France (G.M.); Cardiovascular Engineering, Inc, Norwood, MA (G.F.M.); Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands (G.C.V.); and Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, MD (K.V.T.).

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http://dx.doi.org/10.1161/CIRCGENETICS.113.000456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865635PMC
October 2014

Human CalDAG-GEFI gene (RASGRP2) mutation affects platelet function and causes severe bleeding.

J Exp Med 2014 Jun 23;211(7):1349-62. Epub 2014 Jun 23.

Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1166, F-75013 Paris, France Inserm, UMR_S 1166, Team Genomics and Pathophysiology of Cardiovascular Diseases, F-75013 Paris, France ICAN Institute for Cardiometabolism and Nutrition, F-75013 Paris, France.

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http://jem.rupress.org/content/211/7/1349.full.pdf
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http://www.jem.org/cgi/doi/10.1084/jem.20130477
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http://dx.doi.org/10.1084/jem.20130477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076591PMC
June 2014

Genome-wide association study for circulating tissue plasminogen activator levels and functional follow-up implicates endothelial STXBP5 and STX2.

Authors:
Jie Huang Jennifer E Huffman Munekazu Yamakuchi Munekazu Yamkauchi Stella Trompet Folkert W Asselbergs Maria Sabater-Lleal David-Alexandre Trégouët Wei-Min Chen Nicholas L Smith Marcus E Kleber So-Youn Shin Diane M Becker Weihong Tang Abbas Dehghan Andrew D Johnson Vinh Truong Lasse Folkersen Qiong Yang Tiphaine Oudot-Mellkah Brendan M Buckley Jason H Moore Frances M K Williams Harry Campbell Günther Silbernagel Veronique Vitart Igor Rudan Geoffrey H Tofler Gerjan J Navis Anita Destefano Alan F Wright Ming-Huei Chen Anton J M de Craen Bradford B Worrall Alicja R Rudnicka Ann Rumley Ebony B Bookman Bruce M Psaty Fang Chen Keith L Keene Oscar H Franco Bernhard O Böhm Andre G Uitterlinden Angela M Carter J Wouter Jukema Naveed Sattar Joshua C Bis Mohammad A Ikram Michèle M Sale Barbara McKnight Myriam Fornage Ian Ford Kent Taylor P Eline Slagboom Wendy L McArdle Fang-Chi Hsu Anders Franco-Cereceda Alison H Goodall Lisa R Yanek Karen L Furie Mary Cushman Albert Hofman Jacqueline C M Witteman Aaron R Folsom Saonli Basu Nena Matijevic Wiek H van Gilst James F Wilson Rudi G J Westendorp Sekar Kathiresan Muredach P Reilly Russell P Tracy Ozren Polasek Bernhard R Winkelmann Peter J Grant Hans L Hillege Francois Cambien David J Stott Gordon D Lowe Timothy D Spector James B Meigs Winfried Marz Per Eriksson Lewis C Becker Pierre-Emmanuel Morange Nicole Soranzo Scott M Williams Caroline Hayward Pim van der Harst Anders Hamsten Charles J Lowenstein David P Strachan Christopher J O'Donnell

Arterioscler Thromb Vasc Biol 2014 May 27;34(5):1093-101. Epub 2014 Feb 27.

From National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA (J.H., A.D.J., C.J.O.); Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, MD (J.H., A.D.J., C.J.O.); MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, Scotland, United Kingdom (J.E.H., V.V., A.F.W., C.H.); The Aab Cardiovascular Research Institute, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY (M.Y., C.J.L.); Departments of Cardiology (S.T., J.W.J.), Gerontology and Geriatrics (S.T., A.J.M.d.C., R.G.J.W.), and Molecular Epidemiology (P.E.S.), Leiden University Medical Center, the Netherlands; Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, the Netherlands (F.W.A.); Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, Utrecht, the Netherlands (F.W.A.); Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, London, United Kingdom (F.W.A.); Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit, Department of Medicine (M.S.-L., L.F., P.E., A.H.), Karolinska Institutet, Karolinska University Hospital, Solna, Stockholm, Sweden; INSERM UMRS 937, Pierre et Marie Curie University, Paris, France (D.-A.T., V.T., T.O.M., F.C.); ICAN Institute for Cardiometabolism and Nutrion, Paris, France (D.-A.T., V.T., F.C.); Departments of Public Health Sciences (W.M.C., B.B.W., F.C.) and Biochemistry and Molecular Genetics (M.M.S.), Center for Public Health Genomics, University of Virginia, Charlottesville, VA; Departments of Epidemiology (N.L.S., B.M.P., B.M.), Medicine (B.M.P., J.C.B.), and Health Services (B.M.P.), University of Washington, Seattle, WA; Group Health Research Institute, Group Health Cooperative, Seattle, WA (N.L.S., B.M.P.); Seattle Epidemiologic Research and Information Center, VA Office of Research and

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http://dx.doi.org/10.1161/ATVBAHA.113.302088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4009733PMC
May 2014

Increased monocyte adhesion by endothelial expression of VCAM-1 missense variation in vitro.

Atherosclerosis 2013 Oct 31;230(2):185-90. Epub 2013 Jul 31.

University Hospital Münster, Institute of Sports Medicine, Molecular Genetics of Cardiovascular Disease, Horstmarer Landweg 39, D-48149 Münster, Germany; University Hospital Münster, Internal Medicine D, Nephrology, Hypertension and Rheumatology, Münster, Germany.

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http://dx.doi.org/10.1016/j.atherosclerosis.2013.07.039DOI Listing
October 2013

Cytokine phenotype, genotype, and renal outcomes at cardiac surgery.

Cytokine 2013 Jan 5;61(1):275-84. Epub 2012 Nov 5.

Department of Cardiac Anaesthesia, Belfast Health & Social Care Trust, Belfast BT12 6BA, Northern Ireland, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S10434666120074
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http://dx.doi.org/10.1016/j.cyto.2012.10.008DOI Listing
January 2013

Large-scale association analysis identifies new risk loci for coronary artery disease.

Authors:
Panos Deloukas Stavroula Kanoni Christina Willenborg Martin Farrall Themistocles L Assimes John R Thompson Erik Ingelsson Danish Saleheen Jeanette Erdmann Benjamin A Goldstein Kathleen Stirrups Inke R König Jean-Baptiste Cazier Asa Johansson Alistair S Hall Jong-Young Lee Cristen J Willer John C Chambers Tõnu Esko Lasse Folkersen Anuj Goel Elin Grundberg Aki S Havulinna Weang K Ho Jemma C Hopewell Niclas Eriksson Marcus E Kleber Kati Kristiansson Per Lundmark Leo-Pekka Lyytikäinen Suzanne Rafelt Dmitry Shungin Rona J Strawbridge Gudmar Thorleifsson Emmi Tikkanen Natalie Van Zuydam Benjamin F Voight Lindsay L Waite Weihua Zhang Andreas Ziegler Devin Absher David Altshuler Anthony J Balmforth Inês Barroso Peter S Braund Christof Burgdorf Simone Claudi-Boehm David Cox Maria Dimitriou Ron Do Alex S F Doney NourEddine El Mokhtari Per Eriksson Krista Fischer Pierre Fontanillas Anders Franco-Cereceda Bruna Gigante Leif Groop Stefan Gustafsson Jörg Hager Göran Hallmans Bok-Ghee Han Sarah E Hunt Hyun M Kang Thomas Illig Thorsten Kessler Joshua W Knowles Genovefa Kolovou Johanna Kuusisto Claudia Langenberg Cordelia Langford Karin Leander Marja-Liisa Lokki Anders Lundmark Mark I McCarthy Christa Meisinger Olle Melander Evelin Mihailov Seraya Maouche Andrew D Morris Martina Müller-Nurasyid Kjell Nikus John F Peden N William Rayner Asif Rasheed Silke Rosinger Diana Rubin Moritz P Rumpf Arne Schäfer Mohan Sivananthan Ci Song Alexandre F R Stewart Sian-Tsung Tan Gudmundur Thorgeirsson C Ellen van der Schoot Peter J Wagner George A Wells Philipp S Wild Tsun-Po Yang Philippe Amouyel Dominique Arveiler Hanneke Basart Michael Boehnke Eric Boerwinkle Paolo Brambilla Francois Cambien Adrienne L Cupples Ulf de Faire Abbas Dehghan Patrick Diemert Stephen E Epstein Alun Evans Marco M Ferrario Jean Ferrières Dominique Gauguier Alan S Go Alison H Goodall Villi Gudnason Stanley L Hazen Hilma Holm Carlos Iribarren Yangsoo Jang Mika Kähönen Frank Kee Hyo-Soo Kim Norman Klopp Wolfgang Koenig Wolfgang Kratzer Kari Kuulasmaa Markku Laakso Reijo Laaksonen Ji-Young Lee Lars Lind Willem H Ouwehand Sarah Parish Jeong E Park Nancy L Pedersen Annette Peters Thomas Quertermous Daniel J Rader Veikko Salomaa Eric Schadt Svati H Shah Juha Sinisalo Klaus Stark Kari Stefansson David-Alexandre Trégouët Jarmo Virtamo Lars Wallentin Nicholas Wareham Martina E Zimmermann Markku S Nieminen Christian Hengstenberg Manjinder S Sandhu Tomi Pastinen Ann-Christine Syvänen G Kees Hovingh George Dedoussis Paul W Franks Terho Lehtimäki Andres Metspalu Pierre A Zalloua Agneta Siegbahn Stefan Schreiber Samuli Ripatti Stefan S Blankenberg Markus Perola Robert Clarke Bernhard O Boehm Christopher O'Donnell Muredach P Reilly Winfried März Rory Collins Sekar Kathiresan Anders Hamsten Jaspal S Kooner Unnur Thorsteinsdottir John Danesh Colin N A Palmer Robert Roberts Hugh Watkins Heribert Schunkert Nilesh J Samani

Nat Genet 2013 Jan 2;45(1):25-33. Epub 2012 Dec 2.

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http://dx.doi.org/10.1038/ng.2480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679547PMC
January 2013

Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation.

Blood 2012 Dec 18;120(24):4873-81. Epub 2012 Sep 18.

National Heart, Lung, and Blood Institute (NHBLI) Framingham Heart Study, Framingham, MA 01702, USA.

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http://www.bloodjournal.org/content/120/24/4873.full.pdf
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http://atvb.ahajournals.org/content/34/5/1093.full.pdf
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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2012-06-43
Publisher Site
http://dx.doi.org/10.1182/blood-2012-06-436188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3520624PMC
December 2012

Statistical colocalization of monocyte gene expression and genetic risk variants for type 1 diabetes.

Hum Mol Genet 2012 Jun 8;21(12):2815-24. Epub 2012 Mar 8.

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, University of Cambridge, Addenbrooke’s Hospital, Cambridge, UK.

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http://dx.doi.org/10.1093/hmg/dds098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3363338PMC
June 2012

Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies.

Authors:
Nadeem Sarwar Adam S Butterworth Daniel F Freitag John Gregson Peter Willeit Donal N Gorman Pei Gao Danish Saleheen Augusto Rendon Christopher P Nelson Peter S Braund Alistair S Hall Daniel I Chasman Anne Tybjærg-Hansen John C Chambers Emelia J Benjamin Paul W Franks Robert Clarke Arthur A M Wilde Mieke D Trip Maristella Steri Jacqueline C M Witteman Lu Qi C Ellen van der Schoot Ulf de Faire Jeanette Erdmann Heather M Stringham Wolfgang Koenig Daniel J Rader David Melzer David Reich Bruce M Psaty Marcus E Kleber Demosthenes B Panagiotakos Johann Willeit Patrik Wennberg Mark Woodward Svetlana Adamovic Eric B Rimm Tom W Meade Richard F Gillum Jonathan A Shaffer Albert Hofman Altan Onat Johan Sundström Sylvia Wassertheil-Smoller Dan Mellström John Gallacher Mary Cushman Russell P Tracy Jussi Kauhanen Magnus Karlsson Jukka T Salonen Lars Wilhelmsen Philippe Amouyel Bernard Cantin Lyle G Best Yoav Ben-Shlomo JoAnn E Manson George Davey-Smith Paul I W de Bakker Christopher J O'Donnell James F Wilson Anthony G Wilson Themistocles L Assimes John-Olov Jansson Claes Ohlsson Åsa Tivesten Östen Ljunggren Muredach P Reilly Anders Hamsten Erik Ingelsson Francois Cambien Joseph Hung G Neil Thomas Michael Boehnke Heribert Schunkert Folkert W Asselbergs John J P Kastelein Vilmundur Gudnason Veikko Salomaa Tamara B Harris Jaspal S Kooner Kristine H Allin Børge G Nordestgaard Jemma C Hopewell Alison H Goodall Paul M Ridker Hilma Hólm Hugh Watkins Willem H Ouwehand Nilesh J Samani Stephen Kaptoge Emanuele Di Angelantonio Olivier Harari John Danesh

Bayesian detection of expression quantitative trait loci hot spots.

Genetics 2011 Dec 16;189(4):1449-59. Epub 2011 Sep 16.

MRC Clinical Sciences Centre, Imperial College, London W12 0NN UK.

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http://dx.doi.org/10.1534/genetics.111.131425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3241411PMC
December 2011

New gene functions in megakaryopoiesis and platelet formation.

Authors:
Christian Gieger Aparna Radhakrishnan Ana Cvejic Weihong Tang Eleonora Porcu Giorgio Pistis Jovana Serbanovic-Canic Ulrich Elling Alison H Goodall Yann Labrune Lorna M Lopez Reedik Mägi Stuart Meacham Yukinori Okada Nicola Pirastu Rossella Sorice Alexander Teumer Katrin Voss Weihua Zhang Ramiro Ramirez-Solis Joshua C Bis David Ellinghaus Martin Gögele Jouke-Jan Hottenga Claudia Langenberg Peter Kovacs Paul F O'Reilly So-Youn Shin Tõnu Esko Jaana Hartiala Stavroula Kanoni Federico Murgia Afshin Parsa Jonathan Stephens Pim van der Harst C Ellen van der Schoot Hooman Allayee Antony Attwood Beverley Balkau François Bastardot Saonli Basu Sebastian E Baumeister Ginevra Biino Lorenzo Bomba Amélie Bonnefond François Cambien John C Chambers Francesco Cucca Pio D'Adamo Gail Davies Rudolf A de Boer Eco J C de Geus Angela Döring Paul Elliott Jeanette Erdmann David M Evans Mario Falchi Wei Feng Aaron R Folsom Ian H Frazer Quince D Gibson Nicole L Glazer Chris Hammond Anna-Liisa Hartikainen Susan R Heckbert Christian Hengstenberg Micha Hersch Thomas Illig Ruth J F Loos Jennifer Jolley Kay Tee Khaw Brigitte Kühnel Marie-Christine Kyrtsonis Vasiliki Lagou Heather Lloyd-Jones Thomas Lumley Massimo Mangino Andrea Maschio Irene Mateo Leach Barbara McKnight Yasin Memari Braxton D Mitchell Grant W Montgomery Yusuke Nakamura Matthias Nauck Gerjan Navis Ute Nöthlings Ilja M Nolte David J Porteous Anneli Pouta Peter P Pramstaller Janne Pullat Susan M Ring Jerome I Rotter Daniela Ruggiero Aimo Ruokonen Cinzia Sala Nilesh J Samani Jennifer Sambrook David Schlessinger Stefan Schreiber Heribert Schunkert James Scott Nicholas L Smith Harold Snieder John M Starr Michael Stumvoll Atsushi Takahashi W H Wilson Tang Kent Taylor Albert Tenesa Swee Lay Thein Anke Tönjes Manuela Uda Sheila Ulivi Dirk J van Veldhuisen Peter M Visscher Uwe Völker H-Erich Wichmann Kerri L Wiggins Gonneke Willemsen Tsun-Po Yang Jing Hua Zhao Paavo Zitting John R Bradley George V Dedoussis Paolo Gasparini Stanley L Hazen Andres Metspalu Mario Pirastu Alan R Shuldiner L Joost van Pelt Jaap-Jan Zwaginga Dorret I Boomsma Ian J Deary Andre Franke Philippe Froguel Santhi K Ganesh Marjo-Riitta Jarvelin Nicholas G Martin Christa Meisinger Bruce M Psaty Timothy D Spector Nicholas J Wareham Jan-Willem N Akkerman Marina Ciullo Panos Deloukas Andreas Greinacher Steve Jupe Naoyuki Kamatani Jyoti Khadake Jaspal S Kooner Josef Penninger Inga Prokopenko Derek Stemple Daniela Toniolo Lorenz Wernisch Serena Sanna Andrew A Hicks Augusto Rendon Manuel A Ferreira Willem H Ouwehand Nicole Soranzo

Nature 2011 Nov 30;480(7376):201-8. Epub 2011 Nov 30.

Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr 1, 85764 Neuherberg, Germany.

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http://dx.doi.org/10.1038/nature10659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335296PMC
November 2011

A genome-wide association study identifies LIPA as a susceptibility gene for coronary artery disease.

Circ Cardiovasc Genet 2011 Aug 23;4(4):403-12. Epub 2011 May 23.

Department of Medicine II, University Medical Center Mainz, Germany.

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http://dx.doi.org/10.1161/CIRCGENETICS.110.958728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157552PMC
August 2011

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.

Authors:
Heribert Schunkert Inke R König Sekar Kathiresan Muredach P Reilly Themistocles L Assimes Hilma Holm Michael Preuss Alexandre F R Stewart Maja Barbalic Christian Gieger Devin Absher Zouhair Aherrahrou Hooman Allayee David Altshuler Sonia S Anand Karl Andersen Jeffrey L Anderson Diego Ardissino Stephen G Ball Anthony J Balmforth Timothy A Barnes Diane M Becker Lewis C Becker Klaus Berger Joshua C Bis S Matthijs Boekholdt Eric Boerwinkle Peter S Braund Morris J Brown Mary Susan Burnett Ian Buysschaert John F Carlquist Li Chen Sven Cichon Veryan Codd Robert W Davies George Dedoussis Abbas Dehghan Serkalem Demissie Joseph M Devaney Patrick Diemert Ron Do Angela Doering Sandra Eifert Nour Eddine El Mokhtari Stephen G Ellis Roberto Elosua James C Engert Stephen E Epstein Ulf de Faire Marcus Fischer Aaron R Folsom Jennifer Freyer Bruna Gigante Domenico Girelli Solveig Gretarsdottir Vilmundur Gudnason Jeffrey R Gulcher Eran Halperin Naomi Hammond Stanley L Hazen Albert Hofman Benjamin D Horne Thomas Illig Carlos Iribarren Gregory T Jones J Wouter Jukema Michael A Kaiser Lee M Kaplan John J P Kastelein Kay-Tee Khaw Joshua W Knowles Genovefa Kolovou Augustine Kong Reijo Laaksonen Diether Lambrechts Karin Leander Guillaume Lettre Mingyao Li Wolfgang Lieb Christina Loley Andrew J Lotery Pier M Mannucci Seraya Maouche Nicola Martinelli Pascal P McKeown Christa Meisinger Thomas Meitinger Olle Melander Pier Angelica Merlini Vincent Mooser Thomas Morgan Thomas W Mühleisen Joseph B Muhlestein Thomas Münzel Kiran Musunuru Janja Nahrstaedt Christopher P Nelson Markus M Nöthen Oliviero Olivieri Riyaz S Patel Chris C Patterson Annette Peters Flora Peyvandi Liming Qu Arshed A Quyyumi Daniel J Rader Loukianos S Rallidis Catherine Rice Frits R Rosendaal Diana Rubin Veikko Salomaa M Lourdes Sampietro Manj S Sandhu Eric Schadt Arne Schäfer Arne Schillert Stefan Schreiber Jürgen Schrezenmeir Stephen M Schwartz David S Siscovick Mohan Sivananthan Suthesh Sivapalaratnam Albert Smith Tamara B Smith Jaapjan D Snoep Nicole Soranzo John A Spertus Klaus Stark Kathy Stirrups Monika Stoll W H Wilson Tang Stephanie Tennstedt Gudmundur Thorgeirsson Gudmar Thorleifsson Maciej Tomaszewski Andre G Uitterlinden Andre M van Rij Benjamin F Voight Nick J Wareham George A Wells H-Erich Wichmann Philipp S Wild Christina Willenborg Jaqueline C M Witteman Benjamin J Wright Shu Ye Tanja Zeller Andreas Ziegler Francois Cambien Alison H Goodall L Adrienne Cupples Thomas Quertermous Winfried März Christian Hengstenberg Stefan Blankenberg Willem H Ouwehand Alistair S Hall Panos Deloukas John R Thompson Kari Stefansson Robert Roberts Unnur Thorsteinsdottir Christopher J O'Donnell Ruth McPherson Jeanette Erdmann Nilesh J Samani

Nat Genet 2011 Mar 6;43(4):333-8. Epub 2011 Mar 6.

Universität zu Lübeck, Medizinische Klinik II, Lübeck, Germany.

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http://dx.doi.org/10.1038/ng.784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3119261PMC
March 2011

Contribution of SELP and PSGL-1 genotypes and haplotypes to the presence of coronary heart disease in Tunisians.

Mol Biol Rep 2011 Jan 8;38(1):495-501. Epub 2010 Apr 8.

Research Unit of Biology and Genetics of Cancer, Haematological and Autoimmune Diseases, Monastir, 5000, Tunisia.

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http://dx.doi.org/10.1007/s11033-010-0133-zDOI Listing
January 2011

Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies.

Authors:
Themistocles L Assimes Hilma Hólm Sekar Kathiresan Muredach P Reilly Gudmar Thorleifsson Benjamin F Voight Jeanette Erdmann Christina Willenborg Dhananjay Vaidya Changchun Xie Chris C Patterson Thomas M Morgan Mary Susan Burnett Mingyao Li Mark A Hlatky Joshua W Knowles John R Thompson Devin Absher Carlos Iribarren Alan Go Stephen P Fortmann Stephen Sidney Neil Risch Hua Tang Richard M Myers Klaus Berger Monika Stoll Svati H Shah Gudmundur Thorgeirsson Karl Andersen Aki S Havulinna J Enrique Herrera Nauder Faraday Yoonhee Kim Brian G Kral Rasika A Mathias Ingo Ruczinski Bhoom Suktitipat Alexander F Wilson Lisa R Yanek Lewis C Becker Patrick Linsel-Nitschke Wolfgang Lieb Inke R König Christian Hengstenberg Marcus Fischer Klaus Stark Wibke Reinhard Janina Winogradow Martina Grassl Anika Grosshennig Michael Preuss Stefan Schreiber H-Erich Wichmann Christa Meisinger Jean Yee Yechiel Friedlander Ron Do James B Meigs Gordon Williams David M Nathan Calum A MacRae Liming Qu Robert L Wilensky William H Matthai Atif N Qasim Hakon Hakonarson Augusto D Pichard Kenneth M Kent Lowell Satler Joseph M Lindsay Ron Waksman Christopher W Knouff Dawn M Waterworth Max C Walker Vincent E Mooser Jaume Marrugat Gavin Lucas Isaac Subirana Joan Sala Rafael Ramos Nicola Martinelli Oliviero Olivieri Elisabetta Trabetti Giovanni Malerba Pier Franco Pignatti Candace Guiducci Daniel Mirel Melissa Parkin Joel N Hirschhorn Rosanna Asselta Stefano Duga Kiran Musunuru Mark J Daly Shaun Purcell Sandra Eifert Peter S Braund Benjamin J Wright Anthony J Balmforth Stephen G Ball Willem H Ouwehand Panos Deloukas Michael Scholz Francois Cambien Andreas Huge Thomas Scheffold Veikko Salomaa Domenico Girelli Christopher B Granger Leena Peltonen Pascal P McKeown David Altshuler Olle Melander Joseph M Devaney Stephen E Epstein Daniel J Rader Roberto Elosua James C Engert Sonia S Anand Alistair S Hall Andreas Ziegler Christopher J O'Donnell John A Spertus David Siscovick Stephen M Schwartz Diane Becker Unnur Thorsteinsdottir Kari Stefansson Heribert Schunkert Nilesh J Samani Thomas Quertermous

J Am Coll Cardiol 2010 Nov;56(19):1552-63

Department of Medicine, Stanford University School of Medicine, Stanford, California 94304-1334, USA.

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http://dx.doi.org/10.1016/j.jacc.2010.06.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084526PMC
November 2010

Phospholipolyzed LDL induces an inflammatory response in endothelial cells through endoplasmic reticulum stress signaling.

FASEB J 2010 Sep 29;24(9):3284-97. Epub 2010 Apr 29.

INSERM UMRS 937, Université Pierre et Marie Curie, UPMC-Paris 6, Paris, France.

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http://dx.doi.org/10.1096/fj.09-146852DOI Listing
September 2010

Matrix metalloproteinase-3 and intracranial arterial dolichoectasia.

Ann Neurol 2010 Apr;67(4):508-15

Neurology Department, Versailles Hospital and Versailles Saint-Quentin-en-Yvelines University, Versailles, France.

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http://dx.doi.org/10.1002/ana.21922DOI Listing
April 2010

Association of three polymorphisms selected from a genome-wide association study with coronary heart disease in the Tunisian population.

J Thromb Thrombolysis 2010 Jan;29(1):114-8

Faculty of Pharmacy of Monastir, Research Unit of Biology and Genetics of Cancer, Haematological and Autoimmune Diseases, Monastir, 5000, Tunisia.

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http://dx.doi.org/10.1007/s11239-009-0336-0DOI Listing
January 2010

Low plasma retinol predicts coronary events in healthy middle-aged men: the PRIME Study.

Atherosclerosis 2010 Jan 14;208(1):270-4. Epub 2009 Jul 14.

MONICA Reference Centre for Vitamins-Bern, Department of Biochemistry and Molecular Biology, University of Bern, Switzerland.

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http://dx.doi.org/10.1016/j.atherosclerosis.2009.07.018DOI Listing
January 2010

P-selectin gene polymorphisms and risk of coronary heart disease among Tunisians.

J Thromb Thrombolysis 2009 Oct 11;28(3):314-9. Epub 2008 Dec 11.

Research unit of Biology and Genetics of Cancer, Haematological and Autoimmune Diseases, Faculty of Pharmacy of Monastir, Monastir University, Monastir, Tunisia.

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http://dx.doi.org/10.1007/s11239-008-0297-8DOI Listing
October 2009

Identification and functional analyses of molecular haplotypes of the human osteoprotegerin gene promoter.

Arterioscler Thromb Vasc Biol 2009 Oct 6;29(10):1638-43. Epub 2009 Aug 6.

Leibniz-Institute for Arteriosclerosis Research, University of Münster, Münster, Germany.

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http://dx.doi.org/10.1161/ATVBAHA.109.193532DOI Listing
October 2009

Osteopontin gene variation and cardio/cerebrovascular disease phenotypes.

Atherosclerosis 2009 Sep 21;206(1):209-15. Epub 2009 Feb 21.

Leibniz-Institute for Arteriosclerosis Research, Department of Molecular Genetics of Cardiovascular Disease, University of Muenster, Domagkstrasse 3, Muenster, Germany.

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http://dx.doi.org/10.1016/j.atherosclerosis.2009.02.015DOI Listing
September 2009

Molecular and functional characterization of polymorphisms in the secreted phospholipase A2 group X gene: relevance to coronary artery disease.

J Mol Med (Berl) 2009 Jul 3;87(7):723-33. Epub 2009 Jun 3.

INSERM, UMRS937, UPMC Université Paris 06 and Faculté de Médecine Pierre et Marie Curie, 91, Boulevard de l'Hôpital, 75634, Paris, France.

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http://dx.doi.org/10.1007/s00109-009-0483-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2700867PMC
July 2009

Molecular genetic analysis of a human insulin-like growth factor 1 promoter P1 variation.

FASEB J 2009 May 22;23(5):1303-13. Epub 2008 Dec 22.

Department of Molecular Genetics of Cardiovascular Disease, Leibniz-Institute for Arteriosclerosis Research, University of Münster, Domagkstrasse 3, 48149 Münster, Germany.

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http://dx.doi.org/10.1096/fj.08-116863DOI Listing
May 2009

Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants.

Authors:
Sekar Kathiresan Benjamin F Voight Shaun Purcell Kiran Musunuru Diego Ardissino Pier M Mannucci Sonia Anand James C Engert Nilesh J Samani Heribert Schunkert Jeanette Erdmann Muredach P Reilly Daniel J Rader Thomas Morgan John A Spertus Monika Stoll Domenico Girelli Pascal P McKeown Chris C Patterson David S Siscovick Christopher J O'Donnell Roberto Elosua Leena Peltonen Veikko Salomaa Stephen M Schwartz Olle Melander David Altshuler Diego Ardissino Pier Angelica Merlini Carlo Berzuini Luisa Bernardinelli Flora Peyvandi Marco Tubaro Patrizia Celli Maurizio Ferrario Raffaela Fetiveau Nicola Marziliano Giorgio Casari Michele Galli Flavio Ribichini Marco Rossi Francesco Bernardi Pietro Zonzin Alberto Piazza Pier M Mannucci Stephen M Schwartz David S Siscovick Jean Yee Yechiel Friedlander Roberto Elosua Jaume Marrugat Gavin Lucas Isaac Subirana Joan Sala Rafael Ramos Sekar Kathiresan James B Meigs Gordon Williams David M Nathan Calum A MacRae Christopher J O'Donnell Veikko Salomaa Aki S Havulinna Leena Peltonen Olle Melander Goran Berglund Benjamin F Voight Sekar Kathiresan Joel N Hirschhorn Rosanna Asselta Stefano Duga Marta Spreafico Kiran Musunuru Mark J Daly Shaun Purcell Benjamin F Voight Shaun Purcell James Nemesh Joshua M Korn Steven A McCarroll Stephen M Schwartz Jean Yee Sekar Kathiresan Gavin Lucas Isaac Subirana Roberto Elosua Aarti Surti Candace Guiducci Lauren Gianniny Daniel Mirel Melissa Parkin Noel Burtt Stacey B Gabriel Nilesh J Samani John R Thompson Peter S Braund Benjamin J Wright Anthony J Balmforth Stephen G Ball Alistair S Hall Heribert Schunkert Jeanette Erdmann Patrick Linsel-Nitschke Wolfgang Lieb Andreas Ziegler Inke König Christian Hengstenberg Marcus Fischer Klaus Stark Anika Grosshennig Michael Preuss H-Erich Wichmann Stefan Schreiber Heribert Schunkert Nilesh J Samani Jeanette Erdmann Willem Ouwehand Christian Hengstenberg Panos Deloukas Michael Scholz Francois Cambien Muredach P Reilly Mingyao Li Zhen Chen Robert Wilensky William Matthai Atif Qasim Hakon H Hakonarson Joe Devaney Mary-Susan Burnett Augusto D Pichard Kenneth M Kent Lowell Satler Joseph M Lindsay Ron Waksman Christopher W Knouff Dawn M Waterworth Max C Walker Vincent Mooser Stephen E Epstein Daniel J Rader Thomas Scheffold Klaus Berger Monika Stoll Andreas Huge Domenico Girelli Nicola Martinelli Oliviero Olivieri Roberto Corrocher Thomas Morgan John A Spertus Pascal McKeown Chris C Patterson Heribert Schunkert Erdmann Erdmann Patrick Linsel-Nitschke Wolfgang Lieb Andreas Ziegler Inke R König Christian Hengstenberg Marcus Fischer Klaus Stark Anika Grosshennig Michael Preuss H-Erich Wichmann Stefan Schreiber Hilma Hólm Gudmar Thorleifsson Unnur Thorsteinsdottir Kari Stefansson James C Engert Ron Do Changchun Xie Sonia Anand Sekar Kathiresan Diego Ardissino Pier M Mannucci David Siscovick Christopher J O'Donnell Nilesh J Samani Olle Melander Roberto Elosua Leena Peltonen Veikko Salomaa Stephen M Schwartz David Altshuler

Nat Genet 2009 Mar 8;41(3):334-41. Epub 2009 Feb 8.

Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1038/ng.327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2681011PMC
March 2009

The renin-angiotensin-aldosterone system in cerebral small vessel disease.

J Neurol 2008 Jul 2;255(7):993-1000. Epub 2008 May 2.

INSERM-698 and Coordinating Centre for the GENIC study, Dept. of Neurology and Stroke Centre, Bichat University Hospital and Medical School, Denis Diderot University, 46, rue Henri Huchard, 75018 Paris, France.

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http://dx.doi.org/10.1007/s00415-008-0816-8DOI Listing
July 2008

Cholesterol gene polymorphisms and cardiovascular events.

N Engl J Med 2008 Jul;359(1):92-3; author reply 93

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July 2008

Performance comparison of two microarray platforms to assess differential gene expression in human monocyte and macrophage cells.

BMC Genomics 2008 Jun 25;9:302. Epub 2008 Jun 25.

INSERM UMR S525, Faculté de Médecine Pierre et Marie Curie, Université Paris VI, 91 Boulevard de l'Hôpital, Paris 75634 Cedex 13, France.

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http://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2
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http://dx.doi.org/10.1186/1471-2164-9-302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2464609PMC
June 2008

Thrombomodulin gene polymorphisms in brain infarction and mortality after stroke.

J Neurol 2008 Apr 23;255(4):514-9. Epub 2008 Jan 23.

INSERM U698 and Denis Diderot University - Paris VII, Dept. of Neurology and Stroke Center, Bichat University Hospital, Paris, France.

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http://dx.doi.org/10.1007/s00415-008-0725-xDOI Listing
April 2008

Genetics of cardiovascular diseases: from single mutations to the whole genome.

Circulation 2007 Oct;116(15):1714-24

INSERM UMR S 525 and Université Pierre et Marie Curie, Paris, France.

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https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.106.6
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http://dx.doi.org/10.1161/CIRCULATIONAHA.106.661751DOI Listing
October 2007

Differential haplotypic expression of the interleukin-18 gene.

Eur J Hum Genet 2007 Aug 9;15(8):856-63. Epub 2007 May 9.

INSERM, UMR S 525, Paris, France.

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http://www.nature.com/articles/5201842
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http://dx.doi.org/10.1038/sj.ejhg.5201842DOI Listing
August 2007

Neutrophil elastase gene variation and coronary heart disease.

Pharmacogenet Genomics 2007 Aug;17(8):629-37

Department of Molecular Genetics of Cardiovascular Disease, Leibniz-Institute for Arteriosclerosis Research, University of Muenster, Muenster, Germany.

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http://dx.doi.org/10.1097/FPC.0b013e328042bb46DOI Listing
August 2007

Lack of association between complement factor H polymorphisms and coronary artery disease or myocardial infarction.

J Mol Med (Berl) 2007 Jul 30;85(7):771-5. Epub 2007 Mar 30.

INSERM UMR S525, Faculté de Médecine Pitié-Salpêtrière, 91 Boulevard de l'Hôpital, Paris, 75013, France.

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http://dx.doi.org/10.1007/s00109-007-0185-2DOI Listing
July 2007

Coronary heart disease aetiology: associations and causality.

C R Biol 2007 Apr 23;330(4):299-305. Epub 2007 Mar 23.

Unité mixte 780 Inserm-université Paris-Sud (Paris-11), 16, av. Paul-Vaillant-Couturier, 94907 Villejuif cedex, France.

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http://linkinghub.elsevier.com/retrieve/pii/S163106910700107
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http://dx.doi.org/10.1016/j.crvi.2007.02.016DOI Listing
April 2007

Cytokine polymorphisms associated with carotid intima-media thickness in stroke patients.

Stroke 2006 Jul 1;37(7):1691-6. Epub 2006 Jun 1.

Department of Neurology and Stroke Centre, Bichat University Hospital, Denis Diderot University and Medical School, Paris, France.

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http://dx.doi.org/10.1161/01.STR.0000226565.76113.6cDOI Listing
July 2006

Atherosclerosis: from genetic polymorphisms to system genetics.

Cardiovasc Toxicol 2005 ;5(2):143-52

INSERM U525, Paris.

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October 2005