Publications by authors named "Francois Bertucci"

100Publications

Metabolic-Pathway-Based Subtyping of Triple-Negative Breast Cancer Reveals Potential Therapeutic Targets.

Cell Metab 2021 Jan 11;33(1):51-64.e9. Epub 2020 Nov 11.

Key Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, P.R. China; Precision Cancer Medicine Center, Fudan University Shanghai Cancer Center, Shanghai 200032, P.R. China. Electronic address:

View Article and Find Full Text PDF
January 2021

Novel Therapeutic Insights in Dedifferentiated Liposarcoma: A Role for FGFR and MDM2 Dual Targeting.

Cancers (Basel) 2020 Oct 20;12(10). Epub 2020 Oct 20.

Institute for Research on Cancer and Aging, Nice (IRCAN), Institut National de la Santé et de la Recherche Médicale (INSERM) U1081, Centre National de la Recherche Scientifique (CNRS) UMR7284, Université Côte d'Azur, 06107 Nice, France.

View Article and Find Full Text PDF
October 2020

Theranostic Targeting of CUB Domain Containing Protein 1 (CDCP1) in Pancreatic Cancer-Letter.

Clin Cancer Res 2020 Oct;26(20):5539

Laboratory of Predictive Oncology, Centre de Recherche en Cancérologie de Marseille, Institut Paoli-Calmettes, Aix-Marseille Université, INSERM UMR1068, CNRS UMR725, Marseille, France.

View Article and Find Full Text PDF
October 2020

Genomic landscape of inflammatory breast cancer identifies potential actionable genetic alterations.

Oncoscience 2020 Jul 30;7(7-8):57-59. Epub 2020 Jun 30.

Laboratoire d'Oncologie Prédictive, Centre de Recherche en Cancérologie de Marseille (CRCM), Inserm, U1068, CNRS UMR7258, Institut Paoli-Calmettes, Aix-Marseille Université, Marseille F-13009, France.

View Article and Find Full Text PDF
July 2020

Revisiting the Concept of Stress in the Prognosis of Solid Tumors: A Role for Stress Granules Proteins?

Cancers (Basel) 2020 Sep 1;12(9). Epub 2020 Sep 1.

Predictive Oncology Laboratory, Cancer Research Center of Marseille (CRCM), Inserm U1068, CNRS UMR7258, Institut Paoli-Calmettes, Aix Marseille Université, 13009 Marseille, France.

View Article and Find Full Text PDF
September 2020

Combining poly(ADP-ribose) polymerase inhibitors and immune checkpoint inhibitors in breast cancer: rationale and preliminary clinical results.

Curr Opin Oncol 2020 Nov;32(6):585-593

Medical Oncology Department, Institut Paoli-Calmettes, Aix-Marseille University, INSERM, CNRS, CRCM.

View Article and Find Full Text PDF
November 2020

Enhancement of Breast Cancer Cell Aggressiveness by lncRNA and its Mir-675 Derivative: Insight into Shared and Different Actions.

Cancers (Basel) 2020 Jun 29;12(7). Epub 2020 Jun 29.

University of Lille, CNRS, INSERM, CHU Lille, Centre Oscar Lambret, UMR 9020-UMR 1277-Canther-Cancer Heterogeneity, Plasticity and Resistance to Therapies, F-59000 Lille, France.

View Article and Find Full Text PDF
June 2020

New Therapeutics in HER2-Positive Advanced Breast Cancer: Towards a Change in Clinical Practices?pi.

Cancers (Basel) 2020 Jun 14;12(6). Epub 2020 Jun 14.

Department of Medical Oncology, Inserm U1068, CNRS UMR7258, Institute Paoli-Calmettes, Aix-Marseille University, 13009 Marseille, France.

View Article and Find Full Text PDF
June 2020

PARP Inhibitors in the Treatment of Early Breast Cancer: The Step Beyond?

Cancers (Basel) 2020 May 27;12(6). Epub 2020 May 27.

Medical Oncology Department, Cancer Research Center of Marseille (CRCM), INSERM U1068, CNRS UMR7258, Institut Paoli-Calmettes, Aix-Marseille University, 13009 Marseille, France.

View Article and Find Full Text PDF
May 2020

Quantitative hormone receptor (HR) expression and gene expression analysis in HR+ inflammatory breast cancer (IBC) vs non-IBC.

BMC Cancer 2020 May 18;20(1):430. Epub 2020 May 18.

Morgan Welch Inflammatory Breast Cancer Research Program and Clinic, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030, USA.

View Article and Find Full Text PDF
May 2020

The therapeutic response of ER+/HER2- breast cancers differs according to the molecular Basal or Luminal subtype.

NPJ Breast Cancer 2020 6;6. Epub 2020 Mar 6.

Laboratoire d'Oncologie Prédictive, Centre de Recherche en Cancérologie de Marseille, Inserm U1068, CNRS UMR7258, Institut Paoli-Calmettes, Aix-Marseille Université, Marseille, France.

View Article and Find Full Text PDF
March 2020

Inflammatory breast cancer cells are characterized by abrogated TGFβ1-dependent cell motility and SMAD3 activity.

Breast Cancer Res Treat 2020 Apr 10;180(2):385-395. Epub 2020 Feb 10.

Center for Oncological Research (CORE), Faculty of Medicine and Health Sciences - University of Antwerp, Campus Drie Eiken - Universiteitsplein 1, 2610, Wilrijk - Antwerp, Belgium.

View Article and Find Full Text PDF
April 2020

expression is associated with longer postoperative, survival in adrenocortical carcinoma.

Oncoimmunology 2019;8(11):e1655362. Epub 2019 Aug 28.

Laboratoire Oncologie Prédictive, Centre de Recherche en Cancérologie de Marseille (CRCM), Institut Paoli-Calmettes, INSERM UMR1068, CNRS UMR725, Aix-Marseille Université, Marseille, France.

View Article and Find Full Text PDF
August 2019

Epigenetic down-regulation of the HIST1 locus predicts better prognosis in acute myeloid leukemia with NPM1 mutation.

Clin Epigenetics 2019 10 12;11(1):141. Epub 2019 Oct 12.

Epigenetic Factors in Normal and Malignant Hematopoiesis Team, Aix Marseille University, CNRS, Inserm, Institut Paoli-Calmettes, CRCM, 27 Boulevard Lei Roure, 13273, Marseille Cedex 09, France.

View Article and Find Full Text PDF
October 2019

Successful Imatinib Treatment of an Abdominal Compartment Syndrome due to Huge Gastrointestinal Stromal Tumour.

Case Rep Oncol 2019 May-Aug;12(2):644-649. Epub 2019 Aug 13.

Department of Medical Oncology, Centre de Recherche en Cancérologie de Marseille, INSERM UMR1068, CNRS UMR725, Institut Paoli-Calmettes, Marseille, France.

View Article and Find Full Text PDF
August 2019

[E-health and "Cancer outside the hospital walls", Big Data and artificial intelligence].

Bull Cancer 2020 Jan 19;107(1):102-112. Epub 2019 Sep 19.

Institut Paoli-Calmettes, département d'oncologie médicale, 13009 Marseille, France; Aix-Marseille université, Centre de recherche en cancérologie de Marseille, Inserm U1068-CNRS U7258, 13009 Marseille, France.

View Article and Find Full Text PDF
January 2020

A Tyrosine Kinase Expression Signature Predicts the Post-Operative Clinical Outcome in Triple Negative Breast Cancers.

Cancers (Basel) 2019 Aug 13;11(8). Epub 2019 Aug 13.

Department of Medical Oncology, Institut Paoli-Calmettes, Aix-Marseille Univ, CRCM, CNRS, INSERM, 13000 Marseille, France.

View Article and Find Full Text PDF
August 2019

PD-1/PD-L1 Targeting in Breast Cancer: The First Clinical Evidences Are Emerging. A Literature Review.

Cancers (Basel) 2019 Jul 22;11(7). Epub 2019 Jul 22.

Department of Medical Oncology, Aix-Marseille University, Inserm U1068, CNRS UMR7258, Institute Paoli-Calmettes, 13009 Marseille, France.

View Article and Find Full Text PDF
July 2019

Sensitive and easy screening for circulating tumor cells by flow cytometry.

JCI Insight 2019 06 13;5. Epub 2019 Jun 13.

Predictive Oncology Laboratory, Cancer Research Center of Marseille (CRCM), Inserm U1068, CNRS UMR7258, Institut Paoli-Calmettes, Aix Marseille Université, Marseille, France.

View Article and Find Full Text PDF
June 2019

Liquid Biopsies for Ovarian Carcinoma: How Blood Tests May Improve the Clinical Management of a Deadly Disease.

Cancers (Basel) 2019 Jun 4;11(6). Epub 2019 Jun 4.

CRCM-Predictive Oncology laboratory, Institut Paoli-Calmettes, Inserm, CNRS, Aix-Marseille Univ, 232 Boulevard Sainte Marguerite, 13009 Marseille, France.

View Article and Find Full Text PDF
June 2019

PARP1 expression in soft tissue sarcomas is a poor-prognosis factor and a new potential therapeutic target.

Mol Oncol 2019 07 7;13(7):1577-1588. Epub 2019 Jun 7.

Predictive Oncology Laboratory, Marseille Cancer Research Center (CRCM), Institut Paoli-Calmettes, U1068 INSERM, U7258 CNRS, Aix-Marseille University, Marseille, France.

View Article and Find Full Text PDF
July 2019

A Comparison of DNA Mutation and Copy Number Profiles of Primary Breast Cancers and Paired Brain Metastases for Identifying Clinically Relevant Genetic Alterations in Brain Metastases.

Cancers (Basel) 2019 May 13;11(5). Epub 2019 May 13.

Laboratoire d'Oncologie Prédictive, Centre de Recherche en Cancérologie de Marseille (CRCM), Inserm, U1068, CNRS UMR7258, Aix-Marseille Université, Institut Paoli-Calmettes, F-13009 Marseille, France.

View Article and Find Full Text PDF
May 2019

Expression Is a Poor-Prognosis Marker in Pancreatic Adenocarcinoma.

J Clin Med 2019 Apr 30;8(5). Epub 2019 Apr 30.

Laboratoire d'Oncologie Prédictive, Centre de Recherche en Cancérologie de Marseille, Aix-Marseille Université, INSERM UMR1068, CNRS UMR725, F-13273 Marseille, France.

View Article and Find Full Text PDF
April 2019

ECT2 associated to PRICKLE1 are poor-prognosis markers in triple-negative breast cancer.

Br J Cancer 2019 04 11;120(9):931-940. Epub 2019 Apr 11.

Centre de Recherche en Cancérologie de Marseille, Equipe labellisée 'Predictive oncology' Ligue 2018, Aix Marseille Université, Inserm, CNRS, Institut Paoli Calmettes, 13009, Marseille, France.

View Article and Find Full Text PDF
April 2019

Head and Body/Tail Pancreatic Carcinomas Are Not the Same Tumors.

Cancers (Basel) 2019 Apr 8;11(4). Epub 2019 Apr 8.

Laboratoire Oncologie Prédictive, Centre de Recherche en Cancérologie de Marseille, INSERM UMR1068, CNRS UMR725, Aix-Marseille Université, 13273 Marseille, France.

View Article and Find Full Text PDF
April 2019

Outpatient Cancer Care Delivery in the Context of E-Oncology: A French Perspective on "Cancer outside the Hospital Walls".

Cancers (Basel) 2019 Feb 14;11(2). Epub 2019 Feb 14.

Aix-Marseille Univ, INSERM U1068, CNRS UMR7258, Département d'Oncologie Médicale, Institut Paoli-Calmettes, CRCM, 13009 Marseille, France.

View Article and Find Full Text PDF
February 2019

Targeting Deficiency in Breast Cancer: What are the Clinical Evidences and the Next Perspectives?

Cancers (Basel) 2018 Dec 11;10(12). Epub 2018 Dec 11.

Department of Medical Oncology, Institut Paoli-Calmettes, 13009 Marseille, France.

View Article and Find Full Text PDF
December 2018

The SCRIB Paralog LANO/LRRC1 Regulates Breast Cancer Stem Cell Fate through WNT/β-Catenin Signaling.

Stem Cell Reports 2018 11 18;11(5):1040-1050. Epub 2018 Oct 18.

Centre de Recherche en Cancérologie de Marseille, CRCM, Aix Marseille University, Institut Paoli-Calmettes, CNRS, INSERM, 'Cell Polarity, Cell Signaling and Cancer'- Equipe Labellisée Ligue Contre le Cancer, Marseille, France. Electronic address:

View Article and Find Full Text PDF
November 2018

Rates of immune cell infiltration in patients with triple-negative breast cancer by molecular subtype.

PLoS One 2018 12;13(10):e0204513. Epub 2018 Oct 12.

Morgan Welch Inflammatory Breast Cancer Research Program and Clinic, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America.

View Article and Find Full Text PDF
March 2019

Giant Pedunculated Hepatic Hemangioma: A Case Report and Literature Review.

Case Rep Oncol 2018 May-Aug;11(2):476-484. Epub 2018 Jul 16.

Department of Medical Oncology, Institut Paoli-Calmettes, Marseille, France.

View Article and Find Full Text PDF
July 2018

Reversible rituximab-induced rectal Kaposi's sarcoma misdiagnosed as ulcerative colitis in a patient with HIV-negative follicular lymphoma.

Clin Sarcoma Res 2018 11;8:11. Epub 2018 Jun 11.

1INSERM UMR1068, CNRS UMR725, Department of Medical Oncology, Centre de Recherche en Cancérologie de Marseille (CRCM), Institut Paoli-Calmettes, 232 Bd de Sainte-Marguerite, 13009 Marseille, France.

View Article and Find Full Text PDF
June 2018

Efficacy and safety of regorafenib compared to placebo and to post-cross-over regorafenib in advanced non-adipocytic soft tissue sarcoma.

Eur J Cancer 2018 08 11;99:28-36. Epub 2018 Jun 11.

Department of Clinical Research and Innovation, Centre Oscar Lambret, 3 rue Combemale, 59000 Lille, France; Paris-Saclay University, Univ. Paris-Sud, CESP, INSERM, Gustave Roussy, 94805 Villejuif, France. Electronic address:

View Article and Find Full Text PDF
August 2018

CMTM6 stabilizes PD-L1 expression and refines its prognostic value in tumors.

Ann Transl Med 2018 Feb;6(3):54

Département d'Oncologie Moléculaire, ''Equipe labellisée Ligue Contre le Cancer,'' Centre de Recherche en Cancérologie de Marseille, Inserm UMR1068, UMR7258 CNRS, Aix-Marseille Université, Marseille, France.

View Article and Find Full Text PDF
February 2018

Metastatic Intimal Sarcoma of the Pulmonary Artery Sensitive to Carboplatin-Vinorelbine Chemotherapy: Case Report and Literature Review.

Case Rep Oncol 2018 Jan-Apr;11(1):21-28. Epub 2018 Jan 5.

aDepartment of Medical Oncology, Centre de Recherche en Cancérologie de Marseille (CRCM), Institut Paoli-Calmettes, Marseille, France.

View Article and Find Full Text PDF
January 2018

Impact of Trabectedin Interruption and Subsequent Rechallenge on Progression in Patients With Advanced Soft Tissue Sarcoma: Long-term Follow-up of the T-DIS trial.

Am J Clin Oncol 2018 Nov;41(11):1094-1100

*Medical Oncology Department ‡Methodology and Biostatistics Unit #Clinical Research Unit, Centre Oscar Lambret ∥Medical Oncology, Institut Claudius Regaud, Cedex †Medical Oncology Department, Villejuif §Medical Oncology Department, Centre Léon Bérard, Lyon ¶Medical Oncology Department, Institut Paoli Calmette, Marseille, France.

View Article and Find Full Text PDF
November 2018

Molecular classification as prognostic factor and guide for treatment decision of pancreatic cancer.

Biochim Biophys Acta Rev Cancer 2018 Apr 28;1869(2):248-255. Epub 2018 Feb 28.

Département d'Oncologie Moléculaire, Centre de Recherche en Cancérologie de Marseille, INSERM UMR1068, CNRS UMR7258, Aix-Marseille Université, Marseille, France; Faculté de Médecine, Aix-Marseille Université, Marseille, France.

View Article and Find Full Text PDF
April 2018

[PD-L1 expression and PD-1/PD-L1 inhibitors in breast cancer].

Bull Cancer 2018 Mar 16;105(3):263-274. Epub 2018 Feb 16.

Institut Paoli-Calmettes, département d'oncologie médicale, 232, boulevard de Sainte-Marguerite, 13009 Marseille, France; Aix-Marseille université, centre de recherche en cancérologie de Marseille, Inserm U1068-CNRS U7258, 232, boulevard de Sainte-Marguerite, 13009 Marseille, France; Aix-Marseille université, 13009 Marseille, France.

View Article and Find Full Text PDF
March 2018

"Wnt/β-Catenin in GIST"-Letter.

Mol Cancer Ther 2018 01;17(1):327-328

Department of Molecular Oncology, Centre de Recherche en Cancérologie de Marseille, Institut Paoli-Calmettes, INSERM UMR1068, CNRS UMR7258, Marseille, France.

View Article and Find Full Text PDF
January 2018

Stromal Expression of MARCKS Protein in Ovarian Carcinomas Has Unfavorable Prognostic Value.

Int J Mol Sci 2017 Dec 23;19(1). Epub 2017 Dec 23.

Département d'Oncologie Moléculaire, Centre de Recherche en Cancérologie de Marseille, Institut Paoli-Calmettes, INSERM UMR1068, CNRS UMR7258, Aix-Marseille Université, 13007 Marseille, France.

View Article and Find Full Text PDF
December 2017

[Triple-negative breast cancer therapy via nectin-4 targeting].

Med Sci (Paris) 2017 Nov 4;33(11):936-939. Epub 2017 Dec 4.

Inserm, U1068, CRCM, Équipe oncologie moléculaire, Université d'Aix-Marseille, UM 105, Institut Paoli-Calmettes, CNRS, UMR7258, 27, boulevard Lei Roure, 13009 Marseille, France.

View Article and Find Full Text PDF
November 2017

Validation and comparison of the molecular classifications of pancreatic carcinomas.

Mol Cancer 2017 11 6;16(1):168. Epub 2017 Nov 6.

Département d'Oncologie Moléculaire, Centre de Recherche en Cancérologie de Marseille, Institut Paoli-Calmettes, INSERM UMR1068, CNRS UMR725, Aix-Marseille Université, Marseille, France.

View Article and Find Full Text PDF
November 2017

Wnt Signaling Inhibition Promotes Apoptosis in Sarcomas-Letter.

Mol Cancer Ther 2017 10;16(10):2324

Department of Molecular Oncology, Centre de Recherche en Cancérologie de Marseille, Institut Paoli-Calmettes, INSERM UMR1068, CNRS UMR7258, Marseille, France.

View Article and Find Full Text PDF
October 2017

A 25-gene classifier predicts overall survival in resectable pancreatic cancer.

BMC Med 2017 09 20;15(1):170. Epub 2017 Sep 20.

Département d'Oncologie Moléculaire, Centre de Recherche en Cancérologie de Marseille, Inserm UMR1068, CNRS UMR725, Aix-Marseille Université, Marseille, France.

View Article and Find Full Text PDF
September 2017

Immunotherapy in Breast Cancer: the Emerging Role of PD-1 and PD-L1.

Curr Oncol Rep 2017 Aug 10;19(10):64. Epub 2017 Aug 10.

Department of Medical Oncology, Institut Paoli-Calmettes, 232 Bd. Ste-Marguerite, 13009, Marseille, France.

View Article and Find Full Text PDF
August 2017

Characterization and Targeting of Platelet-Derived Growth Factor Receptor alpha (PDGFRA) in Inflammatory Breast Cancer (IBC).

Neoplasia 2017 Jul 10;19(7):564-573. Epub 2017 Jun 10.

The Laboratory for Cytoskeletal Physiology, Department of Biological Sciences, The University of Delaware, Newark, DE; The Center for Translational Cancer Research, The University of Delaware, Newark, DE; The Helen F. Graham Cancer Center, Newark, DE. Electronic address:

View Article and Find Full Text PDF
July 2017

The use of systemic therapies to prevent progression of inflammatory breast cancer: which targeted therapies to add on cytotoxic combinations?

Expert Rev Anticancer Ther 2017 07 25;17(7):593-606. Epub 2017 May 25.

a Department of Medical Oncology, Institut Paoli-Calmettes, Aix Marseille Univ , CNRS U7258, INSERM U1068, CRCM , Marseille , France.

View Article and Find Full Text PDF
July 2017

PDL1 expression is a poor-prognosis factor in soft-tissue sarcomas.

Oncoimmunology 2017;6(3):e1278100. Epub 2017 Feb 8.

Department of Molecular Oncology, Institut Paoli-Calmettes, Centre de Recherche en Cancérologie de Marseille, UMR1068 Inserm , Marseille, France.

View Article and Find Full Text PDF
February 2017

Prognostic Value of Molecular Subtypes in Pancreatic Cancer.

Pancreas 2017 04;46(4):e29-e31

Département d'Oncologie Moléculaire, Centre de Recherche en Cancérologie de Marseille, INSERM UMR1068, CNRS UMR725, Aix-Marseille Université, Marseille, France, Département d'Oncologie Médicale, Institut Paoli-Calmettes, Marseille, France, Faculté de Médecine, Aix-Marseille Université, Marseille, France, Département d'Oncologie Moléculaire, Centre de Recherche en Cancérologie de Marseille, INSERM UMR1068, CNRS UMR725, Aix-Marseille Université, Marseille, France, Faculté de Médecine, Aix-Marseille Université, Marseille, France, Département de Chirurgie Générale et Viscérale, AP-HM, Marseille, France Département d'Oncologie Moléculaire, Centre de Recherche en Cancérologie de Marseille, INSERM UMR1068, CNRS UMR725, Aix-Marseille Université, Marseille, France Département d'Oncologie Médicale, Institut Paoli-Calmettes, Marseille, France Département d'Anatomopathologie, Institut Paoli-Calmettes, Marseille, France Département d'Oncologie Médicale, Institut Paoli-Calmettes, Marseille, France Département d'Oncologie Moléculaire, Centre de Recherche en Cancérologie de Marseille, INSERM UMR1068, CNRS UMR725, Aix-Marseille Université, Marseille, France.

View Article and Find Full Text PDF
April 2017

[Impact of Her2 and BRCA1/2 status in high-dose chemotherapy and autologous stem cells transplantation in the treatment of breast cancer: The Institut Paoli Calmettes' experience].

Bull Cancer 2017 Apr 16;104(4):332-343. Epub 2017 Feb 16.

Institut Paoli-Calmettes (IPC), département d'oncologie médicale, 232, boulevard de Sainte-Marguerite, 13009 Marseille cedex 9, France; Centre de recherches en cancérologie de Marseille (CRCM), UMR Inserm 1068/CNRS 7258/AMU 105/IPC, 232, boulevard de Sainte-Marguerite, 13009 Marseille, France; Aix-Marseille université, Jardin du Pharo, 58, boulevard Charles-Livon, 13284 Marseille, France. Electronic address:

View Article and Find Full Text PDF
April 2017