Franco Zunino

Franco Zunino

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Franco Zunino

Franco Zunino

Publications by authors named "Franco Zunino"

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c-MYC G-quadruplex binding by the RNA polymerase I inhibitor BMH-21 and analogues revealed by a combined NMR and biochemical Approach.

Biochim Biophys Acta Gen Subj 2018 Mar 8;1862(3):615-629. Epub 2017 Dec 8.

Department of Food, Environmental and Nutritional Sciences, Division of Chemistry and Molecular Biology, Università degli Studi di Milano, via Celoria 2, I-20133 Milano, Italy.

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http://dx.doi.org/10.1016/j.bbagen.2017.12.002DOI Listing
March 2018

Microenvironment modulation and enhancement of antilymphoma therapy by the heparanase inhibitor roneparstat.

Hematol Oncol 2018 Feb 21;36(1):360-362. Epub 2017 Jul 21.

Unit of Immunotherapy and Anticancer Innovative Therapeutics, Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

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http://dx.doi.org/10.1002/hon.2466DOI Listing
February 2018

Low-Temperature Curing Strength Enhancement in Cement-Based Materials Containing Limestone Powder.

Mater Struct 2017 Jun 28;50(3). Epub 2017 Apr 28.

Universidad del Desarrollo, Faculty of Engineering, Avenida La Plaza 680, Las Condes, Santiago, CHILE.

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http://dx.doi.org/10.1617/s11527-017-1042-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5528182PMC
June 2017

Limestone and Silica Powder Replacements for Cement: Early-Age Performance.

Cem Concr Compos 2017 Apr 5;78:43-56. Epub 2017 Jan 5.

National Institute of Standards and Technology, Materials and Structural Systems Division, 100 Bureau Drive, Stop 8615, Gaithersburg, MD 20899 USA.

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http://dx.doi.org/10.1016/j.cemconcomp.2017.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5424712PMC
April 2017

Synthesis and Evaluation of New Naphthalene and Naphthoquinone Derivatives as Anticancer Agents.

Arch Pharm (Weinheim) 2017 Jan 19;350(1). Epub 2016 Dec 19.

Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Padova, Italy.

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http://dx.doi.org/10.1002/ardp.201600286DOI Listing
January 2017

Chemical vs. Physical Acceleration of Cement Hydration.

Concr Int 2016 Nov;38(11):37-44

Sika Technology AG- Central Research, Tueffenwies 16 CH-8048, Zurich, SWITZERLAND.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5220402PMC
November 2016

3-Arylidene-N-hydroxyoxindoles: A New Class of Compounds Endowed with Antitumor Activity.

ChemMedChem 2016 08 17;11(16):1700-4. Epub 2016 Jun 17.

Department of Food, Environmental and Nutritional Sciences, Division of Chemistry and Molecular Biology, University of Milan, via Celoria 2, 20133, Milano, Italy.

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http://dx.doi.org/10.1002/cmdc.201600225DOI Listing
August 2016

Biphenyl-4-yl-acrylohydroxamic acids: Identification of a novel indolyl-substituted HDAC inhibitor with antitumor activity.

Eur J Med Chem 2016 Apr 3;112:99-105. Epub 2016 Feb 3.

Department of Food, Environmental and Nutritional Sciences, Division of Chemistry and Molecular Biology, University of Milan, via Celoria 2, 20133 Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2016.02.001DOI Listing
April 2016

New macrocyclic analogs of the natural histone deacetylase inhibitor FK228; design, synthesis and preliminary biological evaluation.

Bioorg Med Chem 2015 Nov 9;23(21):6785-93. Epub 2015 Oct 9.

Ronzoni Institute for Chemical and Biochem. Research, via G.Colombo 81, 20133 Milano, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2015.10.004DOI Listing
November 2015

Investigation on the ZBG-functionality of phenyl-4-yl-acrylohydroxamic acid derivatives as histone deacetylase inhibitors.

Bioorg Med Chem Lett 2015 Oct 5;25(20):4457-60. Epub 2015 Sep 5.

Department of Food, Environmental and Nutritional Sciences, University of Milan, Via Celoria 2, 20133 Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2015.09.006DOI Listing
October 2015

Perspectives in the development of hybrid bifunctional antitumour agents.

Biochem Pharmacol 2015 Aug 11;96(4):297-305. Epub 2015 Jun 11.

Fondazione IRCCS Istituto Nazionale Tumori, Via Venezian 1, 20133 Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2015.06.006DOI Listing
August 2015

Targeting the invasive phenotype of cisplatin-resistant non-small cell lung cancer cells by a novel histone deacetylase inhibitor.

Biochem Pharmacol 2015 Mar 16;94(2):79-90. Epub 2015 Jan 16.

Molecular Pharmacology Unit, Fondazione IRCCS Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Via Venezian 1/Via Amadeo 42, 20133 Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2015.01.002DOI Listing
March 2015

Differential outcome of MEK1/2 inhibitor-platinum combinations in platinum-sensitive and -resistant ovarian carcinoma cells.

Cancer Lett 2014 Jun 24;347(2):212-24. Epub 2014 Feb 24.

Molecular Pharmacology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, via Amadeo 42, 20133 Milano, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2014.02.016DOI Listing
June 2014

The potential of heparanase as a therapeutic target in cancer.

Biochem Pharmacol 2014 May 22;89(1):12-9. Epub 2014 Feb 22.

Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2014.02.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709407PMC
May 2014

Influence of the adamantyl moiety on the activity of biphenylacrylohydroxamic acid-based HDAC inhibitors.

Eur J Med Chem 2014 May 8;79:251-9. Epub 2014 Apr 8.

Department of Food, Environmental and Nutritional Sciences, Division of Chemistry and Molecular Biology, Università di Milano, Via Celoria 2, 20133 Milano, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2014.04.021DOI Listing
May 2014

Synergistic antitumor activity of cetuximab and namitecan in human squamous cell carcinoma models relies on cooperative inhibition of EGFR expression and depends on high EGFR gene copy number.

Clin Cancer Res 2014 Feb 10;20(4):995-1006. Epub 2013 Dec 10.

Authors' Affiliations: Molecular Pharmacology Unit, Fondazione IRCCS Istituto Nazionale per lo Studio e la Cura dei Tumori; Molecular Pathology Unit, Ospedale Niguarda Ca' Grande, Milan; and Sigma-Tau S.p.A., Pomezia, Italy.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-1684DOI Listing
February 2014

7-Azaindole-1-carboxamides as a new class of PARP-1 inhibitors.

Bioorg Med Chem 2014 Feb 22;22(3):1089-103. Epub 2013 Dec 22.

Department of Food, Environmental and Nutritional Sciences, Division of Chemistry and Molecular Biology, Università di Milano, via Celoria 2, 20133 Milano, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2013.12.031DOI Listing
February 2014

Design, modeling, synthesis and biological activity evaluation of camptothecin-linked platinum anticancer agents.

Eur J Med Chem 2013 May 1;63:387-400. Epub 2013 Mar 1.

Department of Food, Environmental and Nutritional Sciences, Division of Chemistry and Molecular Biology, Università di Milano, Via Celoria 2, 20133 Milano, Italy.

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http://dx.doi.org/10.1016/j.ejmech.2013.02.022DOI Listing
May 2013

Molecular mechanisms of anthracycline activity.

Top Curr Chem 2008 ;283:1-19

Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, 20133, Milan, Italy.

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http://dx.doi.org/10.1007/128_2007_3DOI Listing
April 2013

Camptothecin-7-yl-methanthiole: semisynthesis and biological evaluation.

ChemMedChem 2012 Dec 19;7(12):2134-43. Epub 2012 Oct 19.

Dipartimento di Chimica, Università degli Studi di Milano, Via Golgi 19, 20133 Milano, Italy.

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http://dx.doi.org/10.1002/cmdc.201200322DOI Listing
December 2012

REST controls self-renewal and tumorigenic competence of human glioblastoma cells.

PLoS One 2012 11;7(6):e38486. Epub 2012 Jun 11.

Department of Pharmacological Sciences and Centre for Stem Cell Research, Università degli Studi di Milano, Milano, Italy.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0038486PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3372516PMC
November 2012

Sulfonates-PMMA nanoparticles conjugates: a versatile system for multimodal application.

Bioorg Med Chem 2012 Nov 21;20(22):6640-7. Epub 2012 Sep 21.

Istituto per la Sintesi Organica e la Fotoreattività, CNR-I.S.O.F., Area della Ricerca di Bologna, via P. Gobetti 101, Bologna, Italy.

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http://dx.doi.org/10.1016/j.bmc.2012.09.023DOI Listing
November 2012

Development and therapeutic impact of HDAC6-selective inhibitors.

Biochem Pharmacol 2012 Sep 21;84(6):756-65. Epub 2012 Jun 21.

DeFENS, Department of Food, Environmental and Nutritional Sciences, Università degli Studi di Milano, Milan, Italy.

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http://dx.doi.org/10.1016/j.bcp.2012.06.014DOI Listing
September 2012

Synergistic antitumor effects of novel HDAC inhibitors and paclitaxel in vitro and in vivo.

PLoS One 2011 14;6(12):e29085. Epub 2011 Dec 14.

Molecular Pharmacology Unit, Experimental Oncology and Molecular Medicine, Fondazione Istituto Ricovero Cura Carattere Scientifico Istituto Nazionale Tumori, Milan, Italy.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0029085PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3241602PMC
August 2012

Synergistic interaction between the novel histone deacetylase inhibitor ST2782 and the proteasome inhibitor bortezomib in platinum-sensitive and resistant ovarian carcinoma cells.

J Inorg Biochem 2012 Aug 27;113:94-101. Epub 2012 Apr 27.

Department of Experimental Oncology and Molecular Medicine, Fondazione IRCSS Istituto Nazionale Tumori, via Amadeo 42, 20133 Milan, Italy.

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http://dx.doi.org/10.1016/j.jinorgbio.2012.04.007DOI Listing
August 2012

Sensitization of tumor cells by targeting histone deacetylases.

Biochem Pharmacol 2012 Apr 22;83(8):987-94. Epub 2011 Nov 22.

Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.

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http://dx.doi.org/10.1016/j.bcp.2011.11.010DOI Listing
April 2012

Role of tyrosyl-DNA phosphodiesterase 1 and inter-players in regulation of tumor cell sensitivity to topoisomerase I inhibition.

Biochem Pharmacol 2012 Jan 29;83(1):27-36. Epub 2011 Sep 29.

Molecular Pharmacology Unit, Dept. Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.

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http://dx.doi.org/10.1016/j.bcp.2011.09.021DOI Listing
January 2012

Interplay between Ret and Fap-1 regulates CD95-mediated apoptosis in medullary thyroid cancer cells.

Biochem Pharmacol 2011 Oct 2;82(7):778-88. Epub 2011 Jul 2.

Molecular Pharmacology Unit, Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

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http://dx.doi.org/10.1016/j.bcp.2011.06.037DOI Listing
October 2011

Synthesis, structural, and biological evaluation of bis-heteroarylmaleimides and bis-heterofused imides.

Bioorg Med Chem 2011 Sep 16;19(18):5291-9. Epub 2011 Aug 16.

Dipartimento di Scienze Farmacologiche, Università degli Studi di Milano, Via Balzaretti 9, 20133 Milano, Italy.

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http://linkinghub.elsevier.com/retrieve/pii/S096808961100650
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http://dx.doi.org/10.1016/j.bmc.2011.08.016DOI Listing
September 2011

Proteomic analysis of cellular response to novel proapoptotic agents related to atypical retinoids in human IGROV-1 ovarian carcinoma cells.

J Proteome Res 2011 Mar 18;10(3):1191-207. Epub 2011 Jan 18.

Dipartimento di Biotecnologie, Laboratorio di Proteomica e Spettrometria di Massa, University of Verona, Strada le Grazie 15, 37134, Verona, Italy.

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http://dx.doi.org/10.1021/pr100963nDOI Listing
March 2011

Atomic force microscopy study of DNA conformation in the presence of drugs.

Eur Biophys J 2011 Jan 30;40(1):59-68. Epub 2010 Sep 30.

Department of Experimental Medicine, University of Milano-Bicocca, Via Cadore 48, 20052, Monza, Milan, Italy.

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http://dx.doi.org/10.1007/s00249-010-0627-6DOI Listing
January 2011

Magnetic tweezers measurements of the nanomechanical properties of DNA in the presence of drugs.

Nucleic Acids Res 2010 Nov 3;38(20):7089-99. Epub 2010 Jul 3.

Dipartimento di Medicina Sperimentale, Universita' di Milano-Bicocca, via Cadore 48, Monza (MI) 20052, Italy.

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http://dx.doi.org/10.1093/nar/gkq597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2978368PMC
November 2010

Modulation of cell sensitivity to antitumor agents by targeting survival pathways.

Biochem Pharmacol 2010 Nov 3;80(10):1459-65. Epub 2010 Aug 3.

Molecular Pharmacology Unit, Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale Tumori, Via Venezian 1, 20133 Milan, Italy.

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http://dx.doi.org/10.1016/j.bcp.2010.07.030DOI Listing
November 2010

ATM- and ATR-mediated response to DNA damage induced by a novel camptothecin, ST1968.

Cancer Lett 2010 Jun 29;292(2):186-96. Epub 2009 Dec 29.

Fondazione IRCCS Istituto Nazionale dei Tumori, via Venezian 1, 20133 Milan, Italy.

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http://dx.doi.org/10.1016/j.canlet.2009.12.001DOI Listing
June 2010

Design, synthesis and anticancer activities of stilbene-coumarin hybrid compounds: Identification of novel proapoptotic agents.

Bioorg Med Chem 2010 May 29;18(10):3543-50. Epub 2010 Mar 29.

Dipartimento di Scienze Farmaceutiche, Via Belmeloro, 6, I-40126 Bologna, Italy.

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http://dx.doi.org/10.1016/j.bmc.2010.03.069DOI Listing
May 2010

Increased levels and defective glycosylation of MRPs in ovarian carcinoma cells resistant to oxaliplatin.

Biochem Pharmacol 2010 Apr 31;79(8):1108-17. Epub 2009 Dec 31.

Department of Experimental Oncology and Molecular Medicine, Fondazione IRCSS Istituto Nazionale Tumori, Milan, Italy.

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http://linkinghub.elsevier.com/retrieve/pii/S000629520901059
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http://dx.doi.org/10.1016/j.bcp.2009.12.002DOI Listing
April 2010

Sensitization of ovarian carcinoma cells to the atypical retinoid ST1926 by the histone deacetylase inhibitor, RC307: enhanced DNA damage response.

Int J Cancer 2010 Mar;126(5):1246-55

Preclinical Chemotherapy and Pharmacology Unit, Fondazione IRCCS Istituto Nazionale Tumori, via Venezian 1, 20133 Milan, Italy.

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http://dx.doi.org/10.1002/ijc.24819DOI Listing
March 2010

Concomitant downregulation of proliferation/survival pathways dependent on FGF-R3, JAK2 and BCMA in human multiple myeloma cells by multi-kinase targeting.

Biochem Pharmacol 2009 Nov 23;78(9):1139-47. Epub 2009 Jun 23.

Dipartimento di Oncologia Sperimentale e Medicina Molecolare, Fondazione IRCCS Istituto Nazionale dei Tumori, via Venezian 1, Milan, Italy.

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http://dx.doi.org/10.1016/j.bcp.2009.06.023DOI Listing
November 2009

Strategies to improve the efficacy of platinum compounds.

Curr Med Chem 2009 ;16(19):2355-65

Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, Milan, Italy.

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November 2009

Histone deacetylase and microtubules as targets for the synthesis of releasable conjugate compounds.

Bioorg Med Chem Lett 2009 Nov 30;19(22):6358-63. Epub 2009 Sep 30.

Dipartimento di Chimica Organica e Industriale, Università degli Studi di Milano, Via Venezian 21, Italy.

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http://dx.doi.org/10.1016/j.bmcl.2009.09.075DOI Listing
November 2009

Biological effects of a new vacuolar-H,-ATPase inhibitor in colon carcinoma cell lines.

Ann N Y Acad Sci 2009 Aug;1171:606-16

Fondazione Istituto Di Ricovero e Cura a Carattere Scientifico, Istituto Nazionale Tumori, Milano, Italy.

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http://dx.doi.org/10.1111/j.1749-6632.2009.04705.xDOI Listing
August 2009

Gamma-glutamyltransferase-dependent resistance to arsenic trioxide in melanoma cells and cellular sensitization by ascorbic acid.

Free Radic Biol Med 2009 Jun 17;46(11):1516-26. Epub 2009 Mar 17.

Preclinical Chemotherapy and Pharmacology Unit, Fondazione IRCCS Istituto Nazionale Tumori, via Venezian 1, 20133 Milan, Italy.

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http://dx.doi.org/10.1016/j.freeradbiomed.2009.03.006DOI Listing
June 2009

Targeting RET for thyroid cancer therapy.

Biochem Pharmacol 2009 Feb 6;77(3):297-309. Epub 2008 Nov 6.

Fondazione IRCCS Istituto Nazionale dei Tumori, via Venezian 1, 20133 Milan, Italy.

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http://linkinghub.elsevier.com/retrieve/pii/S000629520800752
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http://dx.doi.org/10.1016/j.bcp.2008.10.033DOI Listing
February 2009

Semisynthesis, biological activity, and molecular modeling studies of C-ring-modified camptothecins.

J Med Chem 2009 Feb;52(4):1029-39

Istituto CNR per la Sintesi Organica e Fotoreattività I.S.O.F., Area della Ricerca di Bologna, Via P. Gobetti 101, 40129 Bologna, Italy.

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http://dx.doi.org/10.1021/jm801153yDOI Listing
February 2009

Interaction between double helix DNA fragments and a new topopyrone acting as human topoisomerase I poison.

Bioorg Med Chem 2009 Jan 10;17(2):484-91. Epub 2008 Dec 10.

Dipartimento di Scienze Molecolari Agroalimentari, Università di Milano, via Celoria 2, 20133 Milano, Italy.

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http://dx.doi.org/10.1016/j.bmc.2008.12.005DOI Listing
January 2009

Synthesis, modeling, and RET protein kinase inhibitory activity of 3- and 4-substituted beta-carbolin-1-ones.

J Med Chem 2008 Dec;51(24):7777-87

Dipartimento di Scienze Molecolari Agroalimentari, Universita di Milano, Via Celoria 2, 20133 Milano, Italy.

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http://dx.doi.org/10.1021/jm8007823DOI Listing
December 2008

A proteomic approach for evaluating the cell response to a novel histone deacetylase inhibitor in colon cancer cells.

Biochim Biophys Acta 2008 Nov 4;1784(11):1702-10. Epub 2008 May 4.

Dipartimento Scientifico e Tecnologico, Laboratorio di Proteomica, Università degli Studi di Verona, Verona, Italy.

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http://dx.doi.org/10.1016/j.bbapap.2008.04.022DOI Listing
November 2008

Semisynthesis of new D-seco-C-nor-taxane derivatives containing a polyfunctionalized furanosyl or cyclopentenyl or cyclopentyl C-ring.

J Org Chem 2008 Nov 22;73(22):8893-900. Epub 2008 Oct 22.

Istituto di Chimica Organica A. Marchesini Facoltà di Farmacia, Università degli Studi di Milano, via Venezian 21, 20133, Milano, Italy.

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http://dx.doi.org/10.1021/jo801458jDOI Listing
November 2008

Targeting topoisomerase I: molecular mechanisms and cellular determinants of response to topoisomerase I inhibitors.

Expert Opin Ther Targets 2008 Oct;12(10):1243-56

Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, 20133 Milan, Italy.

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http://www.tandfonline.com/doi/full/10.1517/14728222.12.10.1
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http://dx.doi.org/10.1517/14728222.12.10.1243 DOI Listing
October 2008

Eradication of ovarian tumor xenografts by locoregional administration of targeted immunotherapy.

Clin Cancer Res 2008 Sep;14(17):5512-8

Preclinical Chemotherapy and Pharmacology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

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http://dx.doi.org/10.1158/1078-0432.CCR-08-0445DOI Listing
September 2008

The human homolog of fission yeast Rad17 is implicated in tumor growth.

Cancer Lett 2008 Aug 18;266(2):194-202. Epub 2008 Apr 18.

Department of Experimental Oncology and Laboratories, Fondazione IRCCS Istituto Nazionale Tumori, via Venezian 1, 20133 Milan, Italy.

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http://dx.doi.org/10.1016/j.canlet.2008.02.057DOI Listing
August 2008

Antitumor efficacy of trastuzumab in nude mice orthotopically xenografted with human pancreatic tumor cells expressing low levels of HER-2/neu.

J Immunother 2008 Jul-Aug;31(6):537-44

Preclinical Chemotherapy and Pharmacology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, Milan, Italy.

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http://dx.doi.org/10.1097/CJI.0b013e31817c37ffDOI Listing
August 2008

Defining targets of modulation of human tumor cell response to cisplatin.

J Inorg Biochem 2008 Jul 8;102(7):1406-15. Epub 2008 Jan 8.

Department of Experimental Oncology and Laboratories, Fondazione IRCCS, Istituto Nazionale per lo Studio e la Cura dei Tumori, Via Venezian 1, 20133 Milan, Italy.

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http://dx.doi.org/10.1016/j.jinorgbio.2008.01.002DOI Listing
July 2008

Cyclic pifithrin-alpha sensitizes wild type p53 tumor cells to antimicrotubule agent-induced apoptosis.

Neoplasia 2008 Jun;10(6):587-96

Department of Experimental Oncology and Laboratories, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2386543PMC
http://dx.doi.org/10.1593/neo.08262DOI Listing
June 2008

Cooperation between p53 and p73 in cisplatin-induced apoptosis in ovarian carcinoma cells.

Cancer Lett 2008 May 7;263(1):140-4. Epub 2008 Feb 7.

Fondazione IRCCS Istituto Nazionale Tumori, via Venezian 1, 20133 Milan, Italy.

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http://dx.doi.org/10.1016/j.canlet.2007.12.024DOI Listing
May 2008

Thiocamptothecin.

J Med Chem 2008 May 18;51(10):3040-4. Epub 2008 Apr 18.

Laboratory of Chemistry Istituto I.S.O.F.-Consiglio Nazionale delle Ricerche (CNR) Via P. Gobetti, 101, 40129-Bologna, Italy.

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http://dx.doi.org/10.1021/jm8001982DOI Listing
May 2008

E-ring-modified 7-oxyiminomethyl camptothecins: Synthesis and preliminary in vitro and in vivo biological evaluation.

Bioorg Med Chem Lett 2008 May 30;18(9):2910-5. Epub 2008 Mar 30.

Sigma-Tau Research & Development, Via Pontina Km 30.400, I-00040 Pomezia, Rome, Italy.

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http://dx.doi.org/10.1016/j.bmcl.2008.03.074DOI Listing
May 2008

Synthesis and cytotoxic activity of new 9-substituted camptothecins.

Bioorg Med Chem Lett 2008 May 10;18(9):2781-7. Epub 2008 Apr 10.

Dipartimento di Scienze Molecolari Agroalimentari, Università di Milano, Via Celoria 2, 20133 Milano, Italy.

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http://dx.doi.org/10.1016/j.bmcl.2008.04.016DOI Listing
May 2008

Combination of metronomic gimatecan and CpG-oligodeoxynucleotides against an orthotopic pancreatic cancer xenograft.

Cancer Biol Ther 2008 Apr 9;7(4):596-601. Epub 2008 Jan 9.

Preclinical Chemotherapy and Pharmacology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

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http://dx.doi.org/10.4161/cbt.7.4.5548DOI Listing
April 2008

Synthesis and biological evaluation of pyrroloiminoquinone derivatives.

Bioorg Med Chem 2008 Mar 28;16(5):2431-8. Epub 2007 Nov 28.

Dipartimento di Chimica Organica e Industriale, Università degli Studi di Milano, Via Venezian 21, 20133 Milano, Italy.

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https://linkinghub.elsevier.com/retrieve/pii/S09680896070102
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http://dx.doi.org/10.1016/j.bmc.2007.11.063DOI Listing
March 2008

Cellular response to oxidative stress and ascorbic acid in melanoma cells overexpressing gamma-glutamyltransferase.

Eur J Cancer 2008 Mar 7;44(5):750-9. Epub 2008 Mar 7.

Preclinical Chemotherapy and Pharmacology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Via Venezian 1, Milan, Italy.

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http://dx.doi.org/10.1016/j.ejca.2008.02.010DOI Listing
March 2008

Modulation of survival pathways in ovarian carcinoma cell lines resistant to platinum compounds.

Mol Cancer Ther 2008 Mar;7(3):679-87

Department of Experimental Oncology and Laboratories, Istituto Nazionale Tumori, Via Venezian 1, Milan, Italy.

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http://dx.doi.org/10.1158/1535-7163.MCT-07-0450DOI Listing
March 2008

Antiproliferative effects on human tumor cells and rat aortic smooth muscular cells of 2,3-heteroarylmaleimides and heterofused imides.

Bioorg Med Chem 2008 Feb 13;16(4):1691-701. Epub 2007 Nov 13.

Dipartimento di Scienze Farmacologiche, Università degli Studi di Milano, via Balzaretti 9, 20133 Milano, Italy.

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http://dx.doi.org/10.1016/j.bmc.2007.11.024DOI Listing
February 2008

Synthesis and cytotoxic activity of a new series of topoisomerase I inhibitors.

Bioorg Med Chem Lett 2008 Feb 25;18(4):1484-9. Epub 2007 Dec 25.

Dipartimento di Scienze Molecolari Agroalimentari, Università di Milano, via Celoria 2, 20133 Milano, Italy.

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http://dx.doi.org/10.1016/j.bmcl.2007.12.055DOI Listing
February 2008

Relevance of extracellular and intracellular interactions of camptothecins as determinants of antitumor activity.

Biochem Pharmacol 2007 Nov 3;74(10):1437-44. Epub 2007 May 3.

Department of Experimental Oncology and Laboratories, Fondazione IRCCS Istituto Nazionale dei Tumori, via Venezian 1, 20133 Milan, Italy.

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http://dx.doi.org/10.1016/j.bcp.2007.04.027DOI Listing
November 2007

Gamma-glutamyltransferase, redox regulation and cancer drug resistance.

Curr Opin Pharmacol 2007 Aug 5;7(4):360-6. Epub 2007 Jul 5.

Dipartimento di Patologia Sperimentale, Università di Pisa, Scuola MedicaVia Roma 55, 56126 Pisa, Italy.

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http://linkinghub.elsevier.com/retrieve/pii/S147148920700090
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http://dx.doi.org/10.1016/j.coph.2007.04.004DOI Listing
August 2007

Synthesis and RET protein kinase inhibitory activity of 3-arylureidobenzylidene-indolin-2-ones.

Bioorg Med Chem Lett 2007 Jul 30;17(14):3962-8. Epub 2007 Apr 30.

Dipartimento di Scienze Molecolari Agroalimentari, Università di Milano, Via Celoria 2, 20133 Milano, Italy.

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http://dx.doi.org/10.1016/j.bmcl.2007.04.091DOI Listing
July 2007

Effect of paclitaxel on intracellular localization of c-Myc and P-c-Myc in prostate carcinoma cell lines.

Ann N Y Acad Sci 2007 Jan;1095:175-81

Istituto Nazionale Tumori, Via Venezian 1, 20133 Milano, Italy.

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http://dx.doi.org/10.1196/annals.1397.021DOI Listing
January 2007

Cucurbitane triterpenes from the fruiting bodies and cultivated mycelia of Leucopaxillus gentianeus.

J Nat Prod 2006 Dec;69(12):1796-9

DISAV, Università degli Studi del Piemonte Orientale, Via Bellini 25G, 15100 Alessandria, Italy.

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http://dx.doi.org/10.1021/np060213nDOI Listing
December 2006

Inhibition of c-Met and prevention of spontaneous metastatic spreading by the 2-indolinone RPI-1.

Mol Cancer Ther 2006 Sep;5(9):2388-97

Department of Experimental Oncology and Laboratories, Preclinical Chemotherapy and Pharmacology Unit, Istituto Nazionale Tumori, via Venezian 1, 20133 Milan, Italy.

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http://dx.doi.org/10.1158/1535-7163.MCT-06-0245DOI Listing
September 2006