Francisco X Real

Francisco X Real

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Francisco X Real

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Vitamin D differentially regulates colon stem cells in patient-derived normal and tumor organoids.

FEBS J 2019 Jul 15. Epub 2019 Jul 15.

Departments of Cancer Biology and Biochemistry, Instituto de Investigaciones Biomédicas 'Alberto Sols', Spanish National Research Council (CSIC)-Autonomous University of Madrid (UAM) and IdiPAZ, Madrid, Spain.

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http://dx.doi.org/10.1111/febs.14998DOI Listing
July 2019

Mouse Models Shed Light on the SLIT/ROBO Pathway in Pancreatic Development and Cancer.

Trends Cancer 2019 Mar 16;5(3):145-148. Epub 2019 Feb 16.

Epithelial Carcinogenesis Group, Spanish National Cancer Research Centre-CNIO, Madrid, Spain; CIBERONC, Madrid, Spain; Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain.

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https://linkinghub.elsevier.com/retrieve/pii/S24058033193002
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http://dx.doi.org/10.1016/j.trecan.2019.02.004DOI Listing
March 2019

Agnostic Pathway/Gene Set Analysis of Genome-Wide Association Data Identifies Associations for Pancreatic Cancer.

Authors:
Naomi Walsh Han Zhang Paula L Hyland Qi Yang Evelina Mocci Mingfeng Zhang Erica J Childs Irene Collins Zhaoming Wang Alan A Arslan Laura Beane-Freeman Paige M Bracci Paul Brennan Federico Canzian Eric J Duell Steven Gallinger Graham G Giles Michael Goggins Gary E Goodman Phyllis J Goodman Rayjean J Hung Charles Kooperberg Robert C Kurtz Núria Malats Loic LeMarchand Rachel E Neale Sara H Olson Ghislaine Scelo Xiao O Shu Stephen K Van Den Eeden Kala Visvanathan Emily White Wei Zheng Demetrius Albanes Gabriella Andreotti Ana Babic William R Bamlet Sonja I Berndt Ayelet Borgida Marie-Christine Boutron-Ruault Lauren Brais Paul Brennan Bas Bueno-de-Mesquita Julie Buring Kari G Chaffee Stephen Chanock Sean Cleary Michelle Cotterchio Lenka Foretova Charles Fuchs J Michael M Gaziano Edward Giovannucci Michael Goggins Thilo Hackert Christopher Haiman Patricia Hartge Manal Hasan Kathy J Helzlsouer Joseph Herman Ivana Holcatova Elizabeth A Holly Robert Hoover Rayjean J Hung Vladimir Janout Eric A Klein Robert C Kurtz Daniel Laheru I-Min Lee Lingeng Lu Núria Malats Satu Mannisto Roger L Milne Ann L Oberg Irene Orlow Alpa V Patel Ulrike Peters Miquel Porta Francisco X Real Nathaniel Rothman Howard D Sesso Gianluca Severi Debra Silverman Oliver Strobel Malin Sund Mark D Thornquist Geoffrey S Tobias Jean Wactawski-Wende Nick Wareham Elisabete Weiderpass Nicolas Wentzensen William Wheeler Herbert Yu Anne Zeleniuch-Jacquotte Peter Kraft Donghui Li Eric J Jacobs Gloria M Petersen Brian M Wolpin Harvey A Risch Laufey T Amundadottir Kai Yu Alison P Klein Rachael Z Stolzenberg-Solomon

J Natl Cancer Inst 2018 Dec 12. Epub 2018 Dec 12.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD.

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https://academic.oup.com/jnci/advance-article/doi/10.1093/jn
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http://dx.doi.org/10.1093/jnci/djy155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6579744PMC
December 2018

Genome-wide association study identifies inversion in the locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis.

Gut 2018 10 28;67(10):1855-1863. Epub 2017 Jul 28.

Department of Molecular and Cell Biology, Center for Exocrine Disorders, Boston University Henry M. Goldman School of Dental Medicine, Boston, Massachusetts, USA.

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http://gut.bmj.com/lookup/doi/10.1136/gutjnl-2017-314454
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http://dx.doi.org/10.1136/gutjnl-2017-314454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145291PMC
October 2018

Genetic unrelatedness of co-occurring pancreatic adenocarcinomas and IPMNs challenges current views of clinical management.

Gut 2018 09 16;67(9):1561-1563. Epub 2018 Apr 16.

Department of Diagnostics and Public Health-Section of Pathology, ARC-Net Research Center, University and Hospital Trust of Verona, Verona, Italy.

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http://dx.doi.org/10.1136/gutjnl-2018-316151DOI Listing
September 2018

Mutant Kras Dosage and Chromothripsis: The Right Ingredients for a Pancreatic Cancer Catastrophe.

Trends Cancer 2018 06 3;4(6):399-401. Epub 2018 May 3.

Epithelial Carcinogenesis Group, Spanish National Cancer Research Centre-CNIO, Madrid, Spain.

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http://dx.doi.org/10.1016/j.trecan.2018.04.004DOI Listing
June 2018

Asthma status is associated with decreased risk of aggressive urothelial bladder cancer.

Int J Cancer 2018 02 16;142(3):470-476. Epub 2017 Oct 16.

Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO), Madrid, CIBERONC, Spain.

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http://dx.doi.org/10.1002/ijc.31066DOI Listing
February 2018

The human PKP2/plakophilin-2 gene is induced by Wnt/β-catenin in normal and colon cancer-associated fibroblasts.

Int J Cancer 2018 02 31;142(4):792-804. Epub 2017 Oct 31.

Instituto de Investigaciones Biomédicas "Alberto Sols", Consejo Superior de Investigaciones Científicas (CSIC) -Universidad Autónoma de Madrid (UAM), Madrid, E-28029, Spain.

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http://dx.doi.org/10.1002/ijc.31104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5765413PMC
February 2018

Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer.

Authors:
Alison P Klein Brian M Wolpin Harvey A Risch Rachael Z Stolzenberg-Solomon Evelina Mocci Mingfeng Zhang Federico Canzian Erica J Childs Jason W Hoskins Ashley Jermusyk Jun Zhong Fei Chen Demetrius Albanes Gabriella Andreotti Alan A Arslan Ana Babic William R Bamlet Laura Beane-Freeman Sonja I Berndt Amanda Blackford Michael Borges Ayelet Borgida Paige M Bracci Lauren Brais Paul Brennan Hermann Brenner Bas Bueno-de-Mesquita Julie Buring Daniele Campa Gabriele Capurso Giulia Martina Cavestro Kari G Chaffee Charles C Chung Sean Cleary Michelle Cotterchio Frederike Dijk Eric J Duell Lenka Foretova Charles Fuchs Niccola Funel Steven Gallinger J Michael M Gaziano Maria Gazouli Graham G Giles Edward Giovannucci Michael Goggins Gary E Goodman Phyllis J Goodman Thilo Hackert Christopher Haiman Patricia Hartge Manal Hasan Peter Hegyi Kathy J Helzlsouer Joseph Herman Ivana Holcatova Elizabeth A Holly Robert Hoover Rayjean J Hung Eric J Jacobs Krzysztof Jamroziak Vladimir Janout Rudolf Kaaks Kay-Tee Khaw Eric A Klein Manolis Kogevinas Charles Kooperberg Matthew H Kulke Juozas Kupcinskas Robert J Kurtz Daniel Laheru Stefano Landi Rita T Lawlor I-Min Lee Loic LeMarchand Lingeng Lu Núria Malats Andrea Mambrini Satu Mannisto Roger L Milne Beatrice Mohelníková-Duchoňová Rachel E Neale John P Neoptolemos Ann L Oberg Sara H Olson Irene Orlow Claudio Pasquali Alpa V Patel Ulrike Peters Raffaele Pezzilli Miquel Porta Francisco X Real Nathaniel Rothman Ghislaine Scelo Howard D Sesso Gianluca Severi Xiao-Ou Shu Debra Silverman Jill P Smith Pavel Soucek Malin Sund Renata Talar-Wojnarowska Francesca Tavano Mark D Thornquist Geoffrey S Tobias Stephen K Van Den Eeden Yogesh Vashist Kala Visvanathan Pavel Vodicka Jean Wactawski-Wende Zhaoming Wang Nicolas Wentzensen Emily White Herbert Yu Kai Yu Anne Zeleniuch-Jacquotte Wei Zheng Peter Kraft Donghui Li Stephen Chanock Ofure Obazee Gloria M Petersen Laufey T Amundadottir

Nat Commun 2018 02 8;9(1):556. Epub 2018 Feb 8.

Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.

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http://dx.doi.org/10.1038/s41467-018-02942-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805680PMC
February 2018

A genetic roadmap of pancreatic cancer: still evolving.

Gut 2017 12 9;66(12):2170-2178. Epub 2017 Oct 9.

Epithelial Carcinogenesis Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.

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http://dx.doi.org/10.1136/gutjnl-2016-313317DOI Listing
December 2017

PIcKing on Fibroblast Growth Factor Receptors as Bladder Cancer Therapeutic Targets.

Eur Urol 2017 06 14;71(6):863-865. Epub 2017 Feb 14.

Epithelial Carcinogenesis Group, Cancer Cell Biology Programme, Spanish National Cancer Research Centre, Madrid, Spain; Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2017.01.049DOI Listing
June 2017

E-cadherin downregulation sensitizes PTEN-mutant tumors to PI3Kβ silencing.

Oncotarget 2016 Dec;7(51):84054-84071

Department of Immunology and Oncology, Centro Nacional de Biotecnología/CSIC, Universidad Autónoma de Madrid, Cantoblanco, Madrid, Spain.

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http://dx.doi.org/10.18632/oncotarget.13414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356644PMC
December 2016

The N-Terminal Phosphorylation of RB by p38 Bypasses Its Inactivation by CDKs and Prevents Proliferation in Cancer Cells.

Mol Cell 2016 10 15;64(1):25-36. Epub 2016 Sep 15.

Cell Signaling Research Group, Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2016.08.015DOI Listing
October 2016

Somatic Embryonic FGFR2 Mutations in Keratinocytic Epidermal Nevi.

J Invest Dermatol 2016 08 19;136(8):1718-1721. Epub 2016 Apr 19.

Department of Dermatology, Parc de Salut Mar, Hospital del Mar, Barcelona, Spain; Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2016.03.040DOI Listing
August 2016

Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome.

Authors:
Mitchell J Machiela Weiyin Zhou Eric Karlins Joshua N Sampson Neal D Freedman Qi Yang Belynda Hicks Casey Dagnall Christopher Hautman Kevin B Jacobs Christian C Abnet Melinda C Aldrich Christopher Amos Laufey T Amundadottir Alan A Arslan Laura E Beane-Freeman Sonja I Berndt Amanda Black William J Blot Cathryn H Bock Paige M Bracci Louise A Brinton H Bas Bueno-de-Mesquita Laurie Burdett Julie E Buring Mary A Butler Federico Canzian Tania Carreón Kari G Chaffee I-Shou Chang Nilanjan Chatterjee Chu Chen Constance Chen Kexin Chen Charles C Chung Linda S Cook Marta Crous Bou Michael Cullen Faith G Davis Immaculata De Vivo Ti Ding Jennifer Doherty Eric J Duell Caroline G Epstein Jin-Hu Fan Jonine D Figueroa Joseph F Fraumeni Christine M Friedenreich Charles S Fuchs Steven Gallinger Yu-Tang Gao Susan M Gapstur Montserrat Garcia-Closas Mia M Gaudet J Michael Gaziano Graham G Giles Elizabeth M Gillanders Edward L Giovannucci Lynn Goldin Alisa M Goldstein Christopher A Haiman Goran Hallmans Susan E Hankinson Curtis C Harris Roger Henriksson Elizabeth A Holly Yun-Chul Hong Robert N Hoover Chao A Hsiung Nan Hu Wei Hu David J Hunter Amy Hutchinson Mazda Jenab Christoffer Johansen Kay-Tee Khaw Hee Nam Kim Yeul Hong Kim Young Tae Kim Alison P Klein Robert Klein Woon-Puay Koh Laurence N Kolonel Charles Kooperberg Peter Kraft Vittorio Krogh Robert C Kurtz Andrea LaCroix Qing Lan Maria Teresa Landi Loic Le Marchand Donghui Li Xiaolin Liang Linda M Liao Dongxin Lin Jianjun Liu Jolanta Lissowska Lingeng Lu Anthony M Magliocco Nuria Malats Keitaro Matsuo Lorna H McNeill Robert R McWilliams Beatrice S Melin Lisa Mirabello Lee Moore Sara H Olson Irene Orlow Jae Yong Park Ana Patiño-Garcia Beata Peplonska Ulrike Peters Gloria M Petersen Loreall Pooler Jennifer Prescott Ludmila Prokunina-Olsson Mark P Purdue You-Lin Qiao Preetha Rajaraman Francisco X Real Elio Riboli Harvey A Risch Benjamin Rodriguez-Santiago Avima M Ruder Sharon A Savage Fredrick Schumacher Ann G Schwartz Kendra L Schwartz Adeline Seow Veronica Wendy Setiawan Gianluca Severi Hongbing Shen Xin Sheng Min-Ho Shin Xiao-Ou Shu Debra T Silverman Margaret R Spitz Victoria L Stevens Rachael Stolzenberg-Solomon Daniel Stram Ze-Zhong Tang Philip R Taylor Lauren R Teras Geoffrey S Tobias David Van Den Berg Kala Visvanathan Sholom Wacholder Jiu-Cun Wang Zhaoming Wang Nicolas Wentzensen William Wheeler Emily White John K Wiencke Brian M Wolpin Maria Pik Wong Chen Wu Tangchun Wu Xifeng Wu Yi-Long Wu Jay S Wunder Lucy Xia Hannah P Yang Pan-Chyr Yang Kai Yu Krista A Zanetti Anne Zeleniuch-Jacquotte Wei Zheng Baosen Zhou Regina G Ziegler Luis A Perez-Jurado Neil E Caporaso Nathaniel Rothman Margaret Tucker Michael C Dean Meredith Yeager Stephen J Chanock

Nat Commun 2016 06 13;7:11843. Epub 2016 Jun 13.

Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1038/ncomms11843DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909985PMC
June 2016

c-MYC partners with BPTF in human cancer.

Mol Cell Oncol 2016 May 18;3(3):e1152346. Epub 2016 Feb 18.

Epithelial Carcinogenesis Group, Cancer Cell Biology Program, Spanish National Cancer Research Center-CNIO , Madrid, Spain.

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http://dx.doi.org/10.1080/23723556.2016.1152346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909403PMC
May 2016

Framework for the Integration of Genomics, Epigenomics and Transcriptomics in Complex Diseases.

Hum Hered 2015 28;79(3-4):124-36. Epub 2015 Jul 28.

Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.

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http://dx.doi.org/10.1159/000381184DOI Listing
April 2016

The acinar regulator Gata6 suppresses KrasG12V-driven pancreatic tumorigenesis in mice.

Gut 2016 Mar 16;65(3):476-86. Epub 2015 Jan 16.

Epithelial Carcinogenesis Group, BBVA Foundation-Cancer Cell Biology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain.

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http://dx.doi.org/10.1136/gutjnl-2014-308042DOI Listing
March 2016

The cis-regulatory switchboard of pancreatic ductal cancer.

EMBO J 2016 Mar 18;35(6):558-60. Epub 2016 Feb 18.

Epithelial Carcinogenesis Group, Cancer Cell Biology Programme, Spanish National Cancer Research Center-CNIO, Madrid, Spain Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain.

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http://dx.doi.org/10.15252/embj.201693999DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4801950PMC
March 2016

Choline Kinase Alpha (CHKα) as a Therapeutic Target in Pancreatic Ductal Adenocarcinoma: Expression, Predictive Value, and Sensitivity to Inhibitors.

Mol Cancer Ther 2016 Feb 14;15(2):323-33. Epub 2016 Jan 14.

Epithelial Carcinogenesis Group, Cancer Cell Biology Programme, Spanish National Cancer Research Center-CNIO, Madrid, Spain. Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain.

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http://dx.doi.org/10.1158/1535-7163.MCT-15-0214DOI Listing
February 2016

Somatic mosaicism: on the road to cancer.

Nat Rev Cancer 2016 01 18;16(1):43-55. Epub 2015 Dec 18.

Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, and at the Epithelial Carcinogenesis Group, Cancer Cell Biology Programme, Spanish National Cancer Research Centre-CNIO, 28029 Madrid, Spain.

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http://www.nature.com/articles/nrc.2015.1
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http://dx.doi.org/10.1038/nrc.2015.1DOI Listing
January 2016

BPTF is required for c-MYC transcriptional activity and in vivo tumorigenesis.

Nat Commun 2016 Jan 5;7:10153. Epub 2016 Jan 5.

Epithelial Carcinogenesis Group, Cancer Cell Biology Programme, Spanish National Cancer Research Center-CNIO, Madrid 28029, Spain.

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http://dx.doi.org/10.1038/ncomms10153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728380PMC
January 2016

Bladder Cancer Molecular Taxonomy: Summary from a Consensus Meeting.

Bladder Cancer 2016 Jan 7;2(1):37-47. Epub 2016 Jan 7.

Epithelial Carcinogenesis Group, Spanish National Cancer Research Centre-CNIO, Madrid, Spain and Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra , Barcelona, Spain.

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http://dx.doi.org/10.3233/BLC-150037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4927916PMC
January 2016

Modification of Occupational Exposures on Bladder Cancer Risk by Common Genetic Polymorphisms.

J Natl Cancer Inst 2015 Nov 14;107(11). Epub 2015 Sep 14.

Division of Cancer Epidemiology and Genetics (JDF, SK, JSC, MGC, MCF, DB, PS, LEM, LPO, ARB, AP, JFFJr, SJC, NC, NR, DTS), Experimental Pathology Laboratory, Laboratory of Pathology, Center for Cancer Research (KY, JYC, SMH), and Cancer and Inflammation Program (MLN), National Cancer Institute, Bethesda, MD; Usher Institute of Population Health Sciences and Informatics, The University of Edinburgh Medical School, Edinburgh UK (JDF); CIBERESP, CIBER Epidemiologia y Salud Publica, Madrid, Spain (MK, AT, JL); Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain (MK); Municipal Institute of Medical Research (IMIM-Hospital del Mar), Barcelona, Spain (MK); Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK (MGC); Spanish National Cancer Research Centre (CNIO), Madrid, Spain (FXR, NM); Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain (FXR, CS); Maine Cancer Registry, Augusta, ME (MS); Vermont Cancer Registry, Burlington, VT (AJ); Geisel School of Medicine at Dartmouth, Hanover, NH (MRK, AS); New Hampshire Department of Health and Human Services, Concord, NH (KRA); Clinical Research Directorate/Clinical Monitoring Research Program, Leidos Biomedical Research, Inc. (formerly SAIC-Frederick, Inc.), Frederick National Laboratory for Cancer Research, Frederick, MD (PL); Molecular Epidemiology Group, Instituto Universitario de Oncologia, Universidad de Oviedo, Oviedo, Asturias, Spain (AT); Hospital Ramón y Cajal, Elche, Madrid, Spain (AC); Unidad de Investigación, Hospital Universitario de Canarias, La Laguna, Spain (RGC).

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http://dx.doi.org/10.1093/jnci/djv223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675099PMC
November 2015

A Multicenter Trial Defining a Serum Protein Signature Associated with Pancreatic Ductal Adenocarcinoma.

Int J Proteomics 2015 26;2015:587250. Epub 2015 Oct 26.

Department of Immunotechnology and CREATE Health, Lund University, Medicon Village 406, 223 81 Lund, Sweden.

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http://dx.doi.org/10.1155/2015/587250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637476PMC
November 2015

Addressing the challenges of pancreatic cancer: future directions for improving outcomes.

Pancreatology 2015 Jan-Feb;15(1):8-18. Epub 2014 Oct 17.

Comprehensive Cancer Centre Munich, Klinikum der Universität München, Munich, Germany.

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http://dx.doi.org/10.1016/j.pan.2014.10.001DOI Listing
October 2015

Mnk1 is a novel acinar cell-specific kinase required for exocrine pancreatic secretion and response to pancreatitis in mice.

Gut 2015 Jun 18;64(6):937-47. Epub 2014 Jul 18.

Epithelial Carcinogenesis Group, Spanish National Cancer Research Center-CNIO, Madrid, Spain Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain.

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http://gut.bmj.com/lookup/doi/10.1136/gutjnl-2013-306068
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http://dx.doi.org/10.1136/gutjnl-2013-306068DOI Listing
June 2015

Intratumour heterogeneity in urologic cancers: from molecular evidence to clinical implications.

Eur Urol 2015 Apr 2;67(4):729-37. Epub 2014 May 2.

CR-UK London Research Institute, London, UK; University College London Cancer Institute, London, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03022838140039
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http://dx.doi.org/10.1016/j.eururo.2014.04.014DOI Listing
April 2015

Epidemiology of bladder cancer.

Hematol Oncol Clin North Am 2015 Apr;29(2):177-89, vii

Epithelial Carcinogenesis Group, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain; Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona 08003, Spain.

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http://dx.doi.org/10.1016/j.hoc.2014.10.001DOI Listing
April 2015

Characterization of large structural genetic mosaicism in human autosomes.

Authors:
Mitchell J Machiela Weiyin Zhou Joshua N Sampson Michael C Dean Kevin B Jacobs Amanda Black Louise A Brinton I-Shou Chang Chu Chen Constance Chen Kexin Chen Linda S Cook Marta Crous Bou Immaculata De Vivo Jennifer Doherty Christine M Friedenreich Mia M Gaudet Christopher A Haiman Susan E Hankinson Patricia Hartge Brian E Henderson Yun-Chul Hong H Dean Hosgood Chao A Hsiung Wei Hu David J Hunter Lea Jessop Hee Nam Kim Yeul Hong Kim Young Tae Kim Robert Klein Peter Kraft Qing Lan Dongxin Lin Jianjun Liu Loic Le Marchand Xiaolin Liang Jolanta Lissowska Lingeng Lu Anthony M Magliocco Keitaro Matsuo Sara H Olson Irene Orlow Jae Yong Park Loreall Pooler Jennifer Prescott Radhai Rastogi Harvey A Risch Fredrick Schumacher Adeline Seow Veronica Wendy Setiawan Hongbing Shen Xin Sheng Min-Ho Shin Xiao-Ou Shu David VanDen Berg Jiu-Cun Wang Nicolas Wentzensen Maria Pik Wong Chen Wu Tangchun Wu Yi-Long Wu Lucy Xia Hannah P Yang Pan-Chyr Yang Wei Zheng Baosen Zhou Christian C Abnet Demetrius Albanes Melinda C Aldrich Christopher Amos Laufey T Amundadottir Sonja I Berndt William J Blot Cathryn H Bock Paige M Bracci Laurie Burdett Julie E Buring Mary A Butler Tania Carreón Nilanjan Chatterjee Charles C Chung Michael B Cook Michael Cullen Faith G Davis Ti Ding Eric J Duell Caroline G Epstein Jin-Hu Fan Jonine D Figueroa Joseph F Fraumeni Neal D Freedman Charles S Fuchs Yu-Tang Gao Susan M Gapstur Ana Patiño-Garcia Montserrat Garcia-Closas J Michael Gaziano Graham G Giles Elizabeth M Gillanders Edward L Giovannucci Lynn Goldin Alisa M Goldstein Mark H Greene Goran Hallmans Curtis C Harris Roger Henriksson Elizabeth A Holly Robert N Hoover Nan Hu Amy Hutchinson Mazda Jenab Christoffer Johansen Kay-Tee Khaw Woon-Puay Koh Laurence N Kolonel Charles Kooperberg Vittorio Krogh Robert C Kurtz Andrea LaCroix Annelie Landgren Maria Teresa Landi Donghui Li Linda M Liao Nuria Malats Katherine A McGlynn Lorna H McNeill Robert R McWilliams Beatrice S Melin Lisa Mirabello Beata Peplonska Ulrike Peters Gloria M Petersen Ludmila Prokunina-Olsson Mark Purdue You-Lin Qiao Kari G Rabe Preetha Rajaraman Francisco X Real Elio Riboli Benjamín Rodríguez-Santiago Nathaniel Rothman Avima M Ruder Sharon A Savage Ann G Schwartz Kendra L Schwartz Howard D Sesso Gianluca Severi Debra T Silverman Margaret R Spitz Victoria L Stevens Rachael Stolzenberg-Solomon Daniel Stram Ze-Zhong Tang Philip R Taylor Lauren R Teras Geoffrey S Tobias Kala Viswanathan Sholom Wacholder Zhaoming Wang Stephanie J Weinstein William Wheeler Emily White John K Wiencke Brian M Wolpin Xifeng Wu Jay S Wunder Kai Yu Krista A Zanetti Anne Zeleniuch-Jacquotte Regina G Ziegler Mariza de Andrade Kathleen C Barnes Terri H Beaty Laura J Bierut Karl C Desch Kimberly F Doheny Bjarke Feenstra David Ginsburg John A Heit Jae H Kang Cecilia A Laurie Jun Z Li William L Lowe Mary L Marazita Mads Melbye Daniel B Mirel Jeffrey C Murray Sarah C Nelson Louis R Pasquale Kenneth Rice Janey L Wiggs Anastasia Wise Margaret Tucker Luis A Pérez-Jurado Cathy C Laurie Neil E Caporaso Meredith Yeager Stephen J Chanock

Am J Hum Genet 2015 Mar;96(3):487-97

Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2015.01.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4375431PMC
March 2015

Inflammatory biomarkers and bladder cancer prognosis: a systematic review.

Eur Urol 2014 Dec 20;66(6):1078-91. Epub 2014 Aug 20.

Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2014.07.033DOI Listing
December 2014

Transcriptome analysis of pancreatic cancer reveals a tumor suppressor function for HNF1A.

Carcinogenesis 2014 Dec 18;35(12):2670-8. Epub 2014 Sep 18.

Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA, Epithelial Carcinogenesis Group, CNIO-Spanish National Cancer Research Centre, E-28029 Madrid, Spain, Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute and Bioinformatics and Molecular Analysis Section, Division of Computational Bioscience, Center for Information Technology, National Institutes of Health, Bethesda, MD 20892, USA, Department of Laboratory Medicine and Pathology and Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA and Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, 08003 Barcelona, Spain

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http://carcin.oxfordjournals.org/content/35/12/2670.full.pdf
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http://www.carcin.oxfordjournals.org/cgi/doi/10.1093/carcin/
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http://dx.doi.org/10.1093/carcin/bgu193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247517PMC
December 2014

Nicotine promotes initiation and progression of KRAS-induced pancreatic cancer via Gata6-dependent dedifferentiation of acinar cells in mice.

Gastroenterology 2014 Nov 12;147(5):1119-33.e4. Epub 2014 Aug 12.

Stem Cells and Cancer Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain; Centre for Stem Cells in Cancer & Ageing, Barts Cancer Institute, Queen Mary University of London, UK. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2014.08.002DOI Listing
November 2014

Ribonucleoprotein HNRNPA2B1 interacts with and regulates oncogenic KRAS in pancreatic ductal adenocarcinoma cells.

Gastroenterology 2014 Oct 3;147(4):882-892.e8. Epub 2014 Jul 3.

Departament de Biologia Cellular, Immunologia i Neurociències, Facultat de Medicina, IDIBAPS, Universitat de Barcelona, Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2014.06.041DOI Listing
October 2014

Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer.

Authors:
Brian M Wolpin Cosmeri Rizzato Peter Kraft Charles Kooperberg Gloria M Petersen Zhaoming Wang Alan A Arslan Laura Beane-Freeman Paige M Bracci Julie Buring Federico Canzian Eric J Duell Steven Gallinger Graham G Giles Gary E Goodman Phyllis J Goodman Eric J Jacobs Aruna Kamineni Alison P Klein Laurence N Kolonel Matthew H Kulke Donghui Li Núria Malats Sara H Olson Harvey A Risch Howard D Sesso Kala Visvanathan Emily White Wei Zheng Christian C Abnet Demetrius Albanes Gabriella Andreotti Melissa A Austin Richard Barfield Daniela Basso Sonja I Berndt Marie-Christine Boutron-Ruault Michelle Brotzman Markus W Büchler H Bas Bueno-de-Mesquita Peter Bugert Laurie Burdette Daniele Campa Neil E Caporaso Gabriele Capurso Charles Chung Michelle Cotterchio Eithne Costello Joanne Elena Niccola Funel J Michael Gaziano Nathalia A Giese Edward L Giovannucci Michael Goggins Megan J Gorman Myron Gross Christopher A Haiman Manal Hassan Kathy J Helzlsouer Brian E Henderson Elizabeth A Holly Nan Hu David J Hunter Federico Innocenti Mazda Jenab Rudolf Kaaks Timothy J Key Kay-Tee Khaw Eric A Klein Manolis Kogevinas Vittorio Krogh Juozas Kupcinskas Robert C Kurtz Andrea LaCroix Maria T Landi Stefano Landi Loic Le Marchand Andrea Mambrini Satu Mannisto Roger L Milne Yusuke Nakamura Ann L Oberg Kouros Owzar Alpa V Patel Petra H M Peeters Ulrike Peters Raffaele Pezzilli Ada Piepoli Miquel Porta Francisco X Real Elio Riboli Nathaniel Rothman Aldo Scarpa Xiao-Ou Shu Debra T Silverman Pavel Soucek Malin Sund Renata Talar-Wojnarowska Philip R Taylor George E Theodoropoulos Mark Thornquist Anne Tjønneland Geoffrey S Tobias Dimitrios Trichopoulos Pavel Vodicka Jean Wactawski-Wende Nicolas Wentzensen Chen Wu Herbert Yu Kai Yu Anne Zeleniuch-Jacquotte Robert Hoover Patricia Hartge Charles Fuchs Stephen J Chanock Rachael S Stolzenberg-Solomon Laufey T Amundadottir

Nat Genet 2014 Sep 3;46(9):994-1000. Epub 2014 Aug 3.

1] Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. [2].

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http://dx.doi.org/10.1038/ng.3052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191666PMC
September 2014

Next-generation sequencing of urologic cancers: next is now.

Eur Urol 2014 Jul 5;66(1):4-7. Epub 2014 Apr 5.

Genetic and Molecular Epidemiology Group, CNIO-Spanish National Cancer Research Center, Madrid, Spain.

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http://dx.doi.org/10.1016/j.eururo.2014.03.028DOI Listing
July 2014

The transcription factor GATA6 enables self-renewal of colon adenoma stem cells by repressing BMP gene expression.

Nat Cell Biol 2014 Jul 22;16(7):695-707. Epub 2014 Jun 22.

1] Institute for Research in Biomedicine (IRB Barcelona), 08028 Barcelona, Spain [2] Institució Catalana de Recerca i Estudis Avançats (ICREA), 08010 Barcelona, Spain.

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http://dx.doi.org/10.1038/ncb2992DOI Listing
July 2014

Nr5a2 heterozygosity sensitises to, and cooperates with, inflammation in KRas(G12V)-driven pancreatic tumourigenesis.

Gut 2014 Apr 18;63(4):647-55. Epub 2013 Apr 18.

Epithelial Carcinogenesis Group, Molecular Pathology Programme, CNIO-Spanish National Cancer Research Center, , Madrid, Spain.

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http://dx.doi.org/10.1136/gutjnl-2012-304381DOI Listing
April 2014

Klf4 and Klf5 differentially inhibit mesoderm and endoderm differentiation in embryonic stem cells.

Nat Commun 2014 Apr 28;5:3719. Epub 2014 Apr 28.

1] Inserm, U846, 18 Avenue Doyen Lepine, Bron 69500, France [2] Stem Cell and Brain Research Institute, Bron 69500, France [3] Université de Lyon, Université Lyon 1, Lyon 69003, France.

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http://dx.doi.org/10.1038/ncomms4719DOI Listing
April 2014

Gata6 is required for complete acinar differentiation and maintenance of the exocrine pancreas in adult mice.

Gut 2013 Oct 21;62(10):1481-8. Epub 2012 Sep 21.

Epithelial Carcinogenesis Group, Molecular Pathology Programme, CNIO-Spanish National Cancer Research Centre, Madrid, Spain.

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http://dx.doi.org/10.1136/gutjnl-2012-303328DOI Listing
October 2013

Bladder cancer and seroreactivity to BK, JC and Merkel cell polyomaviruses: the Spanish bladder cancer study.

Int J Cancer 2013 Aug 27;133(3):597-603. Epub 2013 Feb 27.

Unit of Infections and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology, IDIBELL, 08908 L' Hospitalet de Llobregat, Barcelona, Spain.

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http://doi.wiley.com/10.1002/ijc.28053
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http://dx.doi.org/10.1002/ijc.28053DOI Listing
August 2013

ICAT is a novel Ptf1a interactor that regulates pancreatic acinar differentiation and displays altered expression in tumours.

Biochem J 2013 May;451(3):395-405

Grupo de Carcinogénesis Epitelial, Programa de Patología Molecular, CNIO-Spanish National Cancer Research Center, 28029 Madrid, Spain.

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http://dx.doi.org/10.1042/BJ20120873DOI Listing
May 2013

Pancreatic cancer risk and levels of trace elements.

Gut 2012 Nov 19;61(11):1583-8. Epub 2011 Dec 19.

Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO), C/ Melchor Fernández Almagro 3, Madrid, Spain.

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http://dx.doi.org/10.1136/gutjnl-2011-301086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310963PMC
November 2012

Relationships of hepatic and pancreatic biomarkers with the cholestatic syndrome and tumor stage in pancreatic cancer.

Biomarkers 2012 Sep 16;17(6):557-65. Epub 2012 Jul 16.

Hospital del Mar Research Institute - IMIM, Barcelona, Catalonia, Spain.

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http://dx.doi.org/10.3109/1354750X.2012.701331DOI Listing
September 2012

Gene expression dynamics after murine pancreatitis unveils novel roles for Hnf1α in acinar cell homeostasis.

Gut 2012 Aug 23;61(8):1187-96. Epub 2011 Sep 23.

Grup de Recerca en Patologia Pancreàtica Exocrina, Institut de Recerca Hospital Universitari Vall d'Hebron, Pg Vall d'Hebron 119-129, Barcelona 08035, Spain.

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http://dx.doi.org/10.1136/gutjnl-2011-300360DOI Listing
August 2012

Detectable clonal mosaicism and its relationship to aging and cancer.

Authors:
Kevin B Jacobs Meredith Yeager Weiyin Zhou Sholom Wacholder Zhaoming Wang Benjamin Rodriguez-Santiago Amy Hutchinson Xiang Deng Chenwei Liu Marie-Josephe Horner Michael Cullen Caroline G Epstein Laurie Burdett Michael C Dean Nilanjan Chatterjee Joshua Sampson Charles C Chung Joseph Kovaks Susan M Gapstur Victoria L Stevens Lauren T Teras Mia M Gaudet Demetrius Albanes Stephanie J Weinstein Jarmo Virtamo Philip R Taylor Neal D Freedman Christian C Abnet Alisa M Goldstein Nan Hu Kai Yu Jian-Min Yuan Linda Liao Ti Ding You-Lin Qiao Yu-Tang Gao Woon-Puay Koh Yong-Bing Xiang Ze-Zhong Tang Jin-Hu Fan Melinda C Aldrich Christopher Amos William J Blot Cathryn H Bock Elizabeth M Gillanders Curtis C Harris Christopher A Haiman Brian E Henderson Laurence N Kolonel Loic Le Marchand Lorna H McNeill Benjamin A Rybicki Ann G Schwartz Lisa B Signorello Margaret R Spitz John K Wiencke Margaret Wrensch Xifeng Wu Krista A Zanetti Regina G Ziegler Jonine D Figueroa Montserrat Garcia-Closas Nuria Malats Gaelle Marenne Ludmila Prokunina-Olsson Dalsu Baris Molly Schwenn Alison Johnson Maria Teresa Landi Lynn Goldin Dario Consonni Pier Alberto Bertazzi Melissa Rotunno Preetha Rajaraman Ulrika Andersson Laura E Beane Freeman Christine D Berg Julie E Buring Mary A Butler Tania Carreon Maria Feychting Anders Ahlbom J Michael Gaziano Graham G Giles Goran Hallmans Susan E Hankinson Patricia Hartge Roger Henriksson Peter D Inskip Christoffer Johansen Annelie Landgren Roberta McKean-Cowdin Dominique S Michaud Beatrice S Melin Ulrike Peters Avima M Ruder Howard D Sesso Gianluca Severi Xiao-Ou Shu Kala Visvanathan Emily White Alicja Wolk Anne Zeleniuch-Jacquotte Wei Zheng Debra T Silverman Manolis Kogevinas Juan R Gonzalez Olaya Villa Donghui Li Eric J Duell Harvey A Risch Sara H Olson Charles Kooperberg Brian M Wolpin Li Jiao Manal Hassan William Wheeler Alan A Arslan H Bas Bueno-de-Mesquita Charles S Fuchs Steven Gallinger Myron D Gross Elizabeth A Holly Alison P Klein Andrea LaCroix Margaret T Mandelson Gloria Petersen Marie-Christine Boutron-Ruault Paige M Bracci Federico Canzian Kenneth Chang Michelle Cotterchio Edward L Giovannucci Michael Goggins Judith A Hoffman Bolton Mazda Jenab Kay-Tee Khaw Vittorio Krogh Robert C Kurtz Robert R McWilliams Julie B Mendelsohn Kari G Rabe Elio Riboli Anne Tjønneland Geoffrey S Tobias Dimitrios Trichopoulos Joanne W Elena Herbert Yu Laufey Amundadottir Rachael Z Stolzenberg-Solomon Peter Kraft Fredrick Schumacher Daniel Stram Sharon A Savage Lisa Mirabello Irene L Andrulis Jay S Wunder Ana Patiño García Luis Sierrasesúmaga Donald A Barkauskas Richard G Gorlick Mark Purdue Wong-Ho Chow Lee E Moore Kendra L Schwartz Faith G Davis Ann W Hsing Sonja I Berndt Amanda Black Nicolas Wentzensen Louise A Brinton Jolanta Lissowska Beata Peplonska Katherine A McGlynn Michael B Cook Barry I Graubard Christian P Kratz Mark H Greene Ralph L Erickson David J Hunter Gilles Thomas Robert N Hoover Francisco X Real Joseph F Fraumeni Neil E Caporaso Margaret Tucker Nathaniel Rothman Luis A Pérez-Jurado Stephen J Chanock

Nat Genet 2012 May 6;44(6):651-8. Epub 2012 May 6.

Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), Rockville, Maryland, USA.

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http://dx.doi.org/10.1038/ng.2270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3372921PMC
May 2012

Pancreatic ductal adenocarcinoma and acinar cells: a matter of differentiation and development?

Gut 2012 Mar 5;61(3):449-58. Epub 2011 Jul 5.

Cancer Research Program, Garvan Institute of Medical Research, Darlinghurst-Sydney, NSW, Australia.

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http://gut.bmj.com/lookup/doi/10.1136/gut.2010.235804
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http://dx.doi.org/10.1136/gut.2010.235804DOI Listing
March 2012

Key contribution of CPEB4-mediated translational control to cancer progression.

Nat Med 2011 Dec 4;18(1):83-90. Epub 2011 Dec 4.

Cancer Research Programme, Hospital del Mar Research Institute (IMIM), Barcelona, Spain.

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http://dx.doi.org/10.1038/nm.2540DOI Listing
December 2011

p53-dependent regulation of growth, epithelial-mesenchymal transition and stemness in normal pancreatic epithelial cells.

Cell Cycle 2011 Apr 15;10(8):1312-21. Epub 2011 Apr 15.

Programa de Patología Molecular, Centro Nacional de Investigaciones Oncológicas, Madrid, Spain.

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http://dx.doi.org/10.4161/cc.10.8.15363DOI Listing
April 2011