Francisco Javier Gamo

Francisco Javier Gamo

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Francisco Javier Gamo

Francisco Javier Gamo

Publications by authors named "Francisco Javier Gamo"

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60Publications

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Identification of Small Molecules Disrupting the Ubiquitin Proteasome System in Malaria.

ACS Infect Dis 2019 Dec 7;5(12):2105-2117. Epub 2019 Nov 7.

Tres Cantos Medicines Development Campus, Diseases of the Developing World . GlaxoSmithKline , Severo Ochoa 2 , Tres Cantos , 28760 Madrid , Spain.

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https://pubs.acs.org/doi/10.1021/acsinfecdis.9b00216
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http://dx.doi.org/10.1021/acsinfecdis.9b00216DOI Listing
December 2019

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis.

Proc Natl Acad Sci U S A 2019 04 20;116(14):7015-7020. Epub 2019 Mar 20.

Wellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1814685116
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http://dx.doi.org/10.1073/pnas.1814685116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452685PMC
April 2019

Efforts Aimed To Reduce Attrition in Antimalarial Drug Discovery: A Systematic Evaluation of the Current Antimalarial Targets Portfolio.

ACS Infect Dis 2018 04 24;4(4):568-576. Epub 2018 Jan 24.

Tres Cantos Medicines Development Campus, DDW , GlaxoSmithKline , Severo Ochoa, 2 , 28760 Tres Cantos , Madrid , Spain.

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http://dx.doi.org/10.1021/acsinfecdis.7b00211DOI Listing
April 2018

Identification of Collateral Sensitivity to Dihydroorotate Dehydrogenase Inhibitors in Plasmodium falciparum.

ACS Infect Dis 2018 04 22;4(4):508-515. Epub 2018 Jan 22.

Department of Immunology and Infectious Diseases , Harvard T. H. Chan School of Public Health , 665 Huntington Avenue , Boston , Massachusetts 02115 , United States.

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http://dx.doi.org/10.1021/acsinfecdis.7b00217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899019PMC
April 2018

Development of a Novel High-Density [3H]Hypoxanthine Scintillation Proximity Assay To Assess Plasmodium falciparum Growth.

Antimicrob Agents Chemother 2016 10 23;60(10):5949-56. Epub 2016 Sep 23.

Platform Technology and Science, Centro de Investigación Básica, GlaxoSmithKline, Tres Cantos, Spain.

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http://dx.doi.org/10.1128/AAC.00433-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5038259PMC
October 2016

A high-throughput fluorescence-based assay for Plasmodium dihydroorotate dehydrogenase inhibitor screening.

Anal Biochem 2016 08 29;506:13-21. Epub 2016 Apr 29.

Platform Technology and Science Tres Cantos, GlaxoSmithKline, Centro de Investigación Básica, 28760, Tres Cantos, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.ab.2016.04.013DOI Listing
August 2016

A novel validated assay to support the discovery of new anti-malarial gametocytocidal agents.

Malar J 2016 07 22;15(1):385. Epub 2016 Jul 22.

Tres Cantos Medicines Development Campus, Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, 28760, Madrid, Spain.

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http://dx.doi.org/10.1186/s12936-016-1429-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4957904PMC
July 2016

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.

Authors:
Wesley C Van Voorhis John H Adams Roberto Adelfio Vida Ahyong Myles H Akabas Pietro Alano Aintzane Alday Yesmalie Alemán Resto Aishah Alsibaee Ainhoa Alzualde Katherine T Andrews Simon V Avery Vicky M Avery Lawrence Ayong Mark Baker Stephen Baker Choukri Ben Mamoun Sangeeta Bhatia Quentin Bickle Lotfi Bounaadja Tana Bowling Jürgen Bosch Lauren E Boucher Fabrice F Boyom Jose Brea Marian Brennan Audrey Burton Conor R Caffrey Grazia Camarda Manuela Carrasquilla Dee Carter Maria Belen Cassera Ken Chih-Chien Cheng Worathad Chindaudomsate Anthony Chubb Beatrice L Colon Daisy D Colón-López Yolanda Corbett Gregory J Crowther Noemi Cowan Sarah D'Alessandro Na Le Dang Michael Delves Joseph L DeRisi Alan Y Du Sandra Duffy Shimaa Abd El-Salam El-Sayed Michael T Ferdig José A Fernández Robledo David A Fidock Isabelle Florent Patrick V T Fokou Ani Galstian Francisco Javier Gamo Suzanne Gokool Ben Gold Todd Golub Gregory M Goldgof Rajarshi Guha W Armand Guiguemde Nil Gural R Kiplin Guy Michael A E Hansen Kirsten K Hanson Andrew Hemphill Rob Hooft van Huijsduijnen Takaaki Horii Paul Horrocks Tyler B Hughes Christopher Huston Ikuo Igarashi Katrin Ingram-Sieber Maurice A Itoe Ajit Jadhav Amornrat Naranuntarat Jensen Laran T Jensen Rays H Y Jiang Annette Kaiser Jennifer Keiser Thomas Ketas Sebastien Kicka Sunyoung Kim Kiaran Kirk Vidya P Kumar Dennis E Kyle Maria Jose Lafuente Scott Landfear Nathan Lee Sukjun Lee Adele M Lehane Fengwu Li David Little Liqiong Liu Manuel Llinás Maria I Loza Aristea Lubar Leonardo Lucantoni Isabelle Lucet Louis Maes Dalu Mancama Nuha R Mansour Sandra March Sheena McGowan Iset Medina Vera Stephan Meister Luke Mercer Jordi Mestres Alvine N Mfopa Raj N Misra Seunghyun Moon John P Moore Francielly Morais Rodrigues da Costa Joachim Müller Arantza Muriana Stephen Nakazawa Hewitt Bakela Nare Carl Nathan Nathalie Narraidoo Sujeevi Nawaratna Kayode K Ojo Diana Ortiz Gordana Panic George Papadatos Silvia Parapini Kailash Patra Ngoc Pham Sarah Prats David M Plouffe Sally-Ann Poulsen Anupam Pradhan Celia Quevedo Ronald J Quinn Christopher A Rice Mohamed Abdo Rizk Andrea Ruecker Robert St Onge Rafaela Salgado Ferreira Jasmeet Samra Natalie G Robinett Ulrich Schlecht Marjorie Schmitt Filipe Silva Villela Francesco Silvestrini Robert Sinden Dennis A Smith Thierry Soldati Andreas Spitzmüller Serge Maximilian Stamm David J Sullivan William Sullivan Sundari Suresh Brian M Suzuki Yo Suzuki S Joshua Swamidass Donatella Taramelli Lauve R Y Tchokouaha Anjo Theron David Thomas Kathryn F Tonissen Simon Townson Abhai K Tripathi Valentin Trofimov Kenneth O Udenze Imran Ullah Cindy Vallieres Edgar Vigil Joseph M Vinetz Phat Voong Vinh Hoan Vu Nao-Aki Watanabe Kate Weatherby Pamela M White Andrew F Wilks Elizabeth A Winzeler Edward Wojcik Melanie Wree Wesley Wu Naoaki Yokoyama Paul H A Zollo Nada Abla Benjamin Blasco Jeremy Burrows Benoît Laleu Didier Leroy Thomas Spangenberg Timothy Wells Paul A Willis

PLoS Pathog 2016 07 28;12(7):e1005763. Epub 2016 Jul 28.

Medicines for Malaria Venture, Geneva, Switzerland.

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http://dx.doi.org/10.1371/journal.ppat.1005763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965013PMC
July 2016

In vitro resistance selections for Plasmodium falciparum dihydroorotate dehydrogenase inhibitors give mutants with multiple point mutations in the drug-binding site and altered growth.

J Biol Chem 2014 Jun 29;289(26):17980-95. Epub 2014 Apr 29.

From the Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, the Infectious Disease Initiative, Broad Institute, Cambridge, Massachusetts 02142

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http://dx.doi.org/10.1074/jbc.M114.558353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140291PMC
June 2014

Antimalarial drug resistance: new treatments options for Plasmodium.

Drug Discov Today Technol 2014 Mar;11:81-88

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http://dx.doi.org/10.1016/j.ddtec.2014.03.002DOI Listing
March 2014

Antimalarial drug resistance and early drug discovery.

Curr Pharm Des 2013 ;19(2):270-81

Department of Microbiology, School of Biomedical Sciences, Monash University, Clayton, Victoria, Australia.

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July 2013

Antimalarial drug discovery: recent progress and future directions.

Prog Med Chem 2013 ;52:97-151

Tres Cantos Medicines Development Campus, Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, Spain.

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https://linkinghub.elsevier.com/retrieve/pii/B97804446265230
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http://dx.doi.org/10.1016/B978-0-444-62652-3.00003-XDOI Listing
June 2013

Quinolin-4(1H)-imines are potent antiplasmodial drugs targeting the liver stage of malaria.

J Med Chem 2013 Jun 23;56(11):4811-5. Epub 2013 May 23.

Research Institute for Medicines and Pharmaceutical Sciences (iMed.UL), Faculty of Pharmacy, University of Lisbon, Avenida Prof. Gama Pinto, 1649-019 Lisbon, Portugal.

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http://dx.doi.org/10.1021/jm400246eDOI Listing
June 2013

Discovery and biochemical characterization of Plasmodium thioredoxin reductase inhibitors from an antimalarial set.

Biochemistry 2012 Jun 1;51(23):4764-71. Epub 2012 Jun 1.

GlaxoSmithKline, Medicines Research Centre, Stevenage, Hertfordshire, UK.

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http://dx.doi.org/10.1021/bi3005076DOI Listing
June 2012

Global phenotypic screening for antimalarials.

Chem Biol 2012 Jan;19(1):116-29

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1016/j.chembiol.2012.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3269778PMC
January 2012

Phenotypic screens, chemical genomics, and antimalarial lead discovery.

PLoS Pathog 2011 Aug 18;7(8):e1002156. Epub 2011 Aug 18.

Tres Cantos Medicine Development Campus, Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, Spain.

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http://dx.doi.org/10.1371/journal.ppat.1002156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158047PMC
August 2011