Publications by authors named "Francisco Guarner"

97Publications

Antibiotics as Major Disruptors of Gut Microbiota.

Front Cell Infect Microbiol 2020 24;10:572912. Epub 2020 Nov 24.

Gastroenterology, National School of Medicine, Montevideo, Uruguay.

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November 2020

[Symbiosis in the human gastrointestinal tract].

Nutr Hosp 2021 Jan;37(Spec No2):34-37

Fisiología y Fisiopatología Digestiva. Vall d'Hebron Institut de Recerca (VHIR).

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January 2021

Alterations in Gut Microbiome in Cirrhosis as Assessed by Quantitative Metagenomics: Relationship With Acute-on-Chronic Liver Failure and Prognosis.

Gastroenterology 2021 Jan 14;160(1):206-218.e13. Epub 2020 Sep 14.

Liver Unit, Hospital Clínic de Barcelona, Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Centro de Investigacion en Red de Enfermedades Hepaticas y Digestivas (CIBEReHD), Madrid, Spain. Electronic address:

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January 2021

Recommendations of the Spanish Working Group on Crohn's Disease and Ulcerative Colitis (GETECCU) on pouchitis in ulcerative colitis. Part 2: Treatment.

Gastroenterol Hepatol 2020 Dec 27;43(10):649-658. Epub 2020 Jun 27.

Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III, Madrid, España; Unidad de EII, Servicio de Medicina Digestiva, Hospital Universitario y Politécnico La Fe, Valencia, España.

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December 2020

Editorial: Next-Generation Probiotics: From Commensal Bacteria to Novel Drugs and Food Supplements.

Front Microbiol 2019 27;10:1973. Epub 2019 Aug 27.

INRA, Commensal and Probiotics-Host Interactions Laboratory, Micalis Institute, INRA, AgroParisTech, Université Paris-Saclay, Jouy-en-Josas, France.

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August 2019

Abdominal distension after eating lettuce: The role of intestinal gas evaluated in vitro and by abdominal CT imaging.

Neurogastroenterol Motil 2019 12 11;31(12):e13703. Epub 2019 Aug 11.

Digestive System Research Unit, University Hospital Vall d'Hebron, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (Ciberehd), Barcelona, Spain.

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December 2019

Effects of Prebiotics vs a Diet Low in FODMAPs in Patients With Functional Gut Disorders.

Gastroenterology 2018 10 30;155(4):1004-1007. Epub 2018 Jun 30.

Digestive System Research Unit, University Hospital Vall d'Hebron, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (Ciberehd), Universitat Autònoma de Barcelona, Bellaterra (Cerdanyola del Vallès), Spain. Electronic address:

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October 2018

Crohn's Disease Disturbs the Immune Properties of Human Adipose-Derived Stem Cells Related to Inflammasome Activation.

Stem Cell Reports 2017 10 28;9(4):1109-1123. Epub 2017 Sep 28.

Unitat de Recerca, Hospital Universitari de Tarragona Joan XXIII, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, 43007 Tarragona, Spain; CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, 28014 Madrid, Spain. Electronic address:

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October 2017

Microbiome-Based Diagnostics: Ready for Applications in Laboratory Medicine?

Clin Chem 2017 11 7;63(11):1674-1679. Epub 2017 Sep 7.

Gastroenterologist, Department of Gastroenterology, Beilinson Hospital, Petach Tikva, Israel; Division of Gastroenterology and Hepatology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC.

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November 2017

Effect of Chicory-derived Inulin on Abdominal Sensations and Bowel Motor Function.

J Clin Gastroenterol 2017 Aug;51(7):619-625

*Digestive System Research Unit, University Hospital Vall d'Hebron, Barcelona †Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (Ciberehd) (Virtual Center for Biomedical Research Hepatic and Digestive Diseases), Madrid ‡Department de Medicina, Universitat Autònoma de Barcelona (Department of Medicine, Autonomous University of Barcelona), Bellaterra (Cerdanyola del Vallès), Spain §BENEO-Institute, Obrigheim, Germany.

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August 2017

MetaTrans: an open-source pipeline for metatranscriptomics.

Sci Rep 2016 05 23;6:26447. Epub 2016 May 23.

Digestive Research Unit, Vall d'Hebron Research Institute, Barcelona, 08035, Spain.

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May 2016

Gut Microbiota Linked to Sexual Preference and HIV Infection.

EBioMedicine 2016 Mar 28;5:135-46. Epub 2016 Jan 28.

IrsiCaixa AIDS Research Institute, Ctra de Canyet s/n, 08916 Badalona, Catalonia, Spain; Universitat de Vic-Universitat Central de Catalunya, C. Sagrada Família 7, 08500 Vic, Catalonia, Spain; Universitat Autònoma de Barcelona, 08193 Bellaterra, Catalonia, Spain; HIV Unit & Lluita Contra la SIDA Foundation, Hospital Universitari Germans Trias i Pujol, Ctra de Canyet s/n, 08916 Badalona, Catalonia, Spain.

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March 2016

Transportome Profiling Identifies Profound Alterations in Crohn's Disease Partially Restored by Commensal Bacteria.

J Crohns Colitis 2016 Jul 13;10(7):850-9. Epub 2016 Feb 13.

Molecular Pharmacology and Experimental Therapeutics, Department of Biochemistry and Molecular Biology, Institute of Biomedicine, University of Barcelona, Barcelona, Spain Oncology Program, CIBERehd, National Biomedical Research Institute on Liver and Gastrointestinal Diseases, Instituto de Salud Carlos III, Barcelona, Spain.

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July 2016

Galectin-4 interacts with the drug transporter human concentrative nucleoside transporter 3 to regulate its function.

FASEB J 2016 Feb 19;30(2):544-54. Epub 2015 Oct 19.

*Department of Biochemistry and Molecular Biology, University of Barcelona, Institute of Biomedicine (IBUB), Barcelona, Spain; Oncology Program, National Biomedical Research Institute of Liver and Gastrointestinal Diseases (CIBER EHD), Instituto de Salud Carlos III, Madrid, Spain; and Department of Gastroenterology, Digestive System Research Unit, Institut de Recerca Vall d'Hebron, University Hospital Vall d'Hebron, Universitat Autònoma de Barcelona, CIBER EHD, Barcelona, Spain

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February 2016

Reduction of butyrate- and methane-producing microorganisms in patients with Irritable Bowel Syndrome.

Sci Rep 2015 Aug 4;5:12693. Epub 2015 Aug 4.

1] Digestive System Research Unit, Vall d'Hebron Research Institute, Passeig Vall d'Hebron 119-129, Barcelona 08035, Spain [2] Centro de Investigacion Biomedica en Red en el Área tematica de Enfermedades Heptaticas y Digestivas, CIBERehd, Instituto de Salud Carlos III, Madrid, Spain.

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August 2015

The gut microbiome: What do we know?

Clin Liver Dis (Hoboken) 2015 Apr 7;5(4):86-90. Epub 2015 May 7.

Digestive System Research Unit University Hospital Vall d'Hebron Barcelona Spain.

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April 2015

From basic to applied research: lessons from the human microbiome projects.

J Clin Gastroenterol 2014 Nov-Dec;48 Suppl 1:S3-4

Digestive System Research Unit, University Hospital Vall d'Hebron, CIBEREHD, Barcelona, Spain.

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June 2015

Decade in review-gut microbiota: the gut microbiota era marches on.

Nat Rev Gastroenterol Hepatol 2014 11 9;11(11):647-9. Epub 2014 Sep 9.

Digestive System Research Unit, University Hospital Vall d'Hebron, CIBEREHD, Passeig Vall d'Hebron 119-129, Barcelona E08035, Spain.

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November 2014

Structure and functions of the gut microbiome.

Endocr Metab Immune Disord Drug Targets 2014 ;14(4):290-9

Digestive System Research Unit, Vall d'Hebron Research Institute, Barcelona, Spain.

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September 2015

Digestive Symptoms in Healthy People and Subjects With Irritable Bowel Syndrome: Validation of Symptom Frequency Questionnaire.

J Clin Gastroenterol 2015 Aug;49(7):e64-70

*Digestive System Research Unit, University Hospital Vall d'Hebron, CIBEREHD †Department of Medicine, Autonomous University of Barcelona, Barcelona, Spain ‡Danone Research, Palaiseau §Eurofins Optimed, Gières ∥Biorfortis, Nantes, France.

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August 2015

An integrated catalog of reference genes in the human gut microbiome.

Nat Biotechnol 2014 Aug 6;32(8):834-41. Epub 2014 Jul 6.

1] BGI-Shenzhen, Shenzhen, China. [2] Department of Biology, University of Copenhagen, Copenhagen, Denmark. [3] The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. [4] Princess Al-Jawhara AlBrahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), Faculty of Medicine, KAU, Jeddah, Saudi Arabia. [5] Macau University of Science and Technology, Macau, China.

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August 2014

Hot topics in gut microbiota.

United European Gastroenterol J 2013 Oct;1(5):311-8

Digestive System Research Unit, University Hospital Vall d'Hebron, Barcelona, Spain.

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October 2013

Processing faecal samples: a step forward for standards in microbial community analysis.

BMC Microbiol 2014 May 1;14:112. Epub 2014 May 1.

Vall d'Hebron Research Institute, Digestive System Research Unit, Passeig de la Vall d'Hebron 119-129, Barcelona 08035, Spain.

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May 2014

Short-term effect of antibiotics on human gut microbiota.

PLoS One 2014 18;9(4):e95476. Epub 2014 Apr 18.

Digestive System Research Unit, Vall d'Hebron Research Institute, Barcelona, Spain; Centro de Investigación Biomédica en Red en el Área temática de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain.

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May 2015

Microbiome composition by pyrosequencing in mesenteric lymph nodes of rats with CCl4-induced cirrhosis.

J Innate Immun 2014 29;6(3):263-71. Epub 2013 Nov 29.

Centro de Investigación Biomédica en Red en el Área temática de Enfermedades Hepáticas y Digestivas, Instituto de Salud Carlos III, Madrid, Spain.

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May 2015

[Progress in the knowledge of the intestinal human microbiota].

Nutr Hosp 2013 May-Jun;28(3):553-7

Servicio de Aparato Digestivo, Hospital Universitario Vall d'Hebrón, Barcelona, España.

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June 2014

Anal gas evacuation and colonic microbiota in patients with flatulence: effect of diet.

Gut 2014 Mar 13;63(3):401-8. Epub 2013 Jun 13.

Digestive System Research Unit, Departament de Medicina, University Hospital Vall d'Hebron, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (Ciberehd), Universitat Autònoma de Barcelona, , Barcelona, Spain.

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March 2014

Linking the gut microbiota to human health.

Br J Nutr 2013 Jan;109 Suppl 2:S21-6

Digestive System Research Unit, University Hospital Vall d'Hebron, Ciberehd, Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain.

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January 2013

Phylogenetic analysis of dysbiosis in ulcerative colitis during remission.

Inflamm Bowel Dis 2013 Mar;19(3):481-8

Department for Biotechnology and Biochemical Engineering, Faculty of Technology and Metallurgy, University of Belgrade, Belgrade, Serbia.

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March 2013

Understanding the microbiota in the midst of Renaissance architecture and olive groves.

Nat Immunol 2013 Feb;14(2):101-5

Digestive System Research Unit, University Hospital Vall d'Hebron, Centro de Investigación Biomédica en Red en Área temática de Enfermedades Hepáticas y Digestivas, Barcelona, Spain.

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February 2013

The intestinal microbiome, probiotics and prebiotics in neurogastroenterology.

Gut Microbes 2013 Jan-Feb;4(1):17-27. Epub 2012 Nov 30.

NIZO Food Research, Ede, The Netherlands, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA.

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July 2013

The gut microbiota in IBD.

Nat Rev Gastroenterol Hepatol 2012 Oct 21;9(10):599-608. Epub 2012 Aug 21.

Digestive System Research Unit, University Hospital Vall d'Hebron, Barcelona, Spain.

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October 2012

Storage conditions of intestinal microbiota matter in metagenomic analysis.

BMC Microbiol 2012 Jul 30;12:158. Epub 2012 Jul 30.

Digestive System Research Unit, Vall d'Hebron Institut de Recerca, Ciberehd, Barcelona, Spain.

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July 2012

Lactobacillus paracasei and Lactobacillus plantarum strains downregulate proinflammatory genes in an ex vivo system of cultured human colonic mucosa.

Genes Nutr 2013 Mar 6;8(2):165-80. Epub 2012 Jun 6.

Department of Food Biotechnology, Instituto de Agroquímica y Tecnología de Alimentos, Spanish National Research Council (CSIC), Valencia, Spain.

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March 2013

Restoration of quality of life of patients with inflammatory bowel disease after one year with antiTNFα treatment.

J Crohns Colitis 2012 Oct 14;6(9):881-6. Epub 2012 Feb 14.

Unitat Atenció Crohn-Colitis, Hospital Universitari Vall d'Hebron, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (Ciberehd), Barcelona, Spain.

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October 2012

Enterotypes of the human gut microbiome.

Nature 2011 May 20;473(7346):174-80. Epub 2011 Apr 20.

European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany.

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May 2011

[The intestinal microbiota and inflammatory bowel disease].

Gastroenterol Hepatol 2011 Mar 5;34(3):147-54. Epub 2011 Mar 5.

Unidad de Investigación de Aparato Digestivo, Hospital Universitari Vall d'Hebron, Barcelona, España.

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March 2011

Reshaping the gut microbiome with bacterial transplantation and antibiotic intake.

Genome Res 2010 Oct 24;20(10):1411-9. Epub 2010 Aug 24.

Digestive System Research Unit, University Hospital Vall d'Hebron, Ciberehd, 08035 Barcelona, Spain.

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October 2010

[Probiotics and the digestive system. Current evidence].

Gastroenterol Hepatol 2009 May;32 Suppl 1:1-14

Centro Médico Teknon, Barcelona, España.

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May 2009

Prebiotics, probiotics and helminths: the 'natural' solution?

Dig Dis 2009 24;27(3):412-7. Epub 2009 Sep 24.

Digestive System Research Unit, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), University Hospital Vall d'Hebron, ES-08035 Barcelona, Spain.

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December 2009

Adhesion properties of Lactobacillus casei strains to resected intestinal fragments and components of the extracellular matrix.

Arch Microbiol 2009 Feb 31;191(2):153-61. Epub 2008 Oct 31.

Biotechnology Department, Instituto de Agroquímica y Tecnología de Alimentos-CSIC, P.O. Box 73, Burjassot, 46100, Valencia, Spain.

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February 2009

Lactobacillus casei downregulates commensals' inflammatory signals in Crohn's disease mucosa.

Inflamm Bowel Dis 2009 Feb;15(2):275-83

Digestive System Research Unit, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (Ciberehd), Barcelona, Spain.

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February 2009

What is the role of the enteric commensal flora in IBD?

Inflamm Bowel Dis 2008 Oct;14 Suppl 2:S83-4

Digestive System Research Unit, University Hospital Vall d'Hebron, Barcelona, Spain.

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October 2008

The gut microbiota predispose to the pathophysiology of acute postradiotherapy diarrhea.

Am J Gastroenterol 2008 Jul 28;103(7):1754-61. Epub 2008 Jun 28.

Unité d'Ecologie et de Physiologie du système Digestif, INRA, Jouy-en-Josas, France.

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July 2008

Prebiotics in inflammatory bowel diseases.

Br J Nutr 2007 Oct;98 Suppl 1:S85-9

Digestive System Research Unit Ciberehd University Hospital Vall d'Hebron Passeig Vall d'Hebron, 119-129 08035 Barcelona, Spain.

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October 2007

Studies with inulin-type fructans on intestinal infections, permeability, and inflammation.

J Nutr 2007 11;137(11 Suppl):2568S-2571S

Digestive System Research Unit, University Hospital Vall d'Hebron, CIBEREHD, Barcelona, Spain.

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November 2007

Hygiene, microbial diversity and immune regulation.

Curr Opin Gastroenterol 2007 Nov;23(6):667-72

Digestive System Research Unit, Ciberehd, University Hospital Vall d'Hebron, Barcelona, Spain.

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November 2007

Lactobacillus casei prevents the upregulation of ICAM-1 expression and leukocyte recruitment in experimental colitis.

Am J Physiol Gastrointest Liver Physiol 2006 Dec 10;291(6):G1155-62. Epub 2006 Aug 10.

Department of Gastroenterology, Hospital Clínic of Barcelona, University of Barcelona, Barcelona, Spain.

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December 2006

Prebiotics and mucosal barrier function.

J Nutr 2006 08;136(8):2269; author reply 2270-1

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August 2006

Modulation of apoptosis in intestinal lymphocytes by a probiotic bacteria in Crohn's disease.

J Leukoc Biol 2006 May;79(5):917-22

Digestive System Research Unit, University Hospital Vall d'Hebron, Autonomous University of Barcelona, Barcelona, Spain.

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May 2006

Enteric flora in health and disease.

Digestion 2006 8;73 Suppl 1:5-12. Epub 2006 Feb 8.

Digestive System Research Unit, University Hospital Vall d'Hebron, Barcelona, Spain.

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June 2006

Should yoghurt cultures be considered probiotic?

Br J Nutr 2005 Jun;93(6):783-6

Digestive System Research Unit, University Hospital Vall d'Hebron, Barcelona, Spain.

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June 2005

The intestinal flora in inflammatory bowel disease: normal or abnormal?

Curr Opin Gastroenterol 2005 Jul;21(4):414-8

Digestive System Research Unit, University Hospital Vall d'Hebron, Barcelona, Spain.

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July 2005

Inulin and oligofructose: impact on intestinal diseases and disorders.

Br J Nutr 2005 Apr;93 Suppl 1:S61-5

Digestive System Research Unit, University Hospital Vall d'Hebron, Passeig Vall d'Hebron 119-129, Barcelona 08035, Spain.

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April 2005

Role of bacteria in experimental colitis.

Best Pract Res Clin Gastroenterol 2003 Oct;17(5):793-804

Digestive System Research Unit, Hospital General Vall d'Hebron, Barcelona 08035, Spain.

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October 2003

Microecology as a target for therapeutic intervention in inflammatory bowel disease.

IDrugs 2003 Sep;6(9):868-73

University Hospital Vall d'Hebron, Digestive System Research Unit, Passeig Vall d'Hebron, 119-129, E-08035 Barcelona, Spain.

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September 2003

Effects of nonpathogenic bacteria on cytokine secretion by human intestinal mucosa.

Am J Gastroenterol 2003 Apr;98(4):865-70

Digestive System Research Unit, Hospitals Vall d'Hebron, Universidad Autónoma de Barcelona, Barcelona, Spain.

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April 2003

Gut flora in health and disease.

Lancet 2003 Feb;361(9356):512-9

Digestive System Research Unit, Hospital General Vall d'Hebron, Barcelona, Spain.

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February 2003

Increased activity and expression of matrix metalloproteinase-9 in a rat model of distal colitis.

Am J Physiol Gastrointest Liver Physiol 2003 Jan 11;284(1):G116-22. Epub 2002 Sep 11.

Digestive Disease Research Unit, Hospital Vall d'Hebron, 08035 Barcelona, Spain.

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January 2003