Francisco Estevez

Francisco Estevez

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Francisco Estevez

Publications by authors named "Francisco Estevez"

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6'-Benzyloxy-4-bromo-2'-hydroxychalcone is cytotoxic against human leukaemia cells and induces caspase-8- and reactive oxygen species-dependent apoptosis.

Chem Biol Interact 2019 Jan 19;298:137-145. Epub 2018 Dec 19.

Departamento de Bioquímica y Biología Molecular, Unidad Asociada al Consejo Superior de Investigaciones Científicas (CSIC), Instituto Universitario de Investigaciones Biomédicas y Sanitarias (IUIBS), Universidad de las Palmas de Gran Canaria, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.cbi.2018.12.010DOI Listing
January 2019

Synthesis and biological evaluation of alpha-bromoacryloylamido indolyl pyridinyl propenones as potent apoptotic inducers in human leukaemia cells.

J Enzyme Inhib Med Chem 2018 Dec;33(1):727-742

c Departamento de Bioquímica y Biología Molecular , Instituto Universitario de Investigaciones Biomédicas y Sanitarias, Universidad de las Palmas de Gran Canaria , Spain.

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http://dx.doi.org/10.1080/14756366.2018.1450749DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009983PMC
December 2018

3'-Hydroxy-3,4'-dimethoxyflavone-induced cell death in human leukaemia cells is dependent on caspases and reactive oxygen species and attenuated by the inhibition of JNK/SAPK.

Chem Biol Interact 2018 May 6;288:1-11. Epub 2018 Apr 6.

Departamento de Bioquímica y Biología Molecular, Unidad Asociada al Consejo Superior de Investigaciones Científicas (CSIC), Instituto Universitario de Investigaciones Biomédicas y Sanitarias, Universidad de las Palmas de Gran Canaria, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.cbi.2018.04.006DOI Listing
May 2018

Anticancer properties of the abietane diterpene 6,7-dehydroroyleanone obtained by optimized extraction.

Future Med Chem 2018 05 11;10(10):1177-1189. Epub 2018 May 11.

Research Center for Biosciences & Health Technologies (CBIOS), Universidade Lusófona de Humanidades e Tecnologias, 1749-024 Lisbon, Portugal.

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http://dx.doi.org/10.4155/fmc-2017-0239DOI Listing
May 2018

Use of the Perceval Sutureless Valve in Active Prosthetic Aortic Valve Endocarditis.

Ann Thorac Surg 2018 Apr 9;105(4):1168-1174. Epub 2017 Dec 9.

Department of Cardiac Surgery, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.

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http://dx.doi.org/10.1016/j.athoracsur.2017.11.031DOI Listing
April 2018

Recent Advances on Cytotoxic Sesquiterpene Lactones.

Curr Pharm Des 2018 ;24(36):4355-4361

Department of Biochemistry and Molecular Biology, Research Institute in Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.

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http://dx.doi.org/10.2174/1381612825666190119114323DOI Listing
January 2018

3'-Hydroxy-3,4'-dimethoxyflavone blocks tubulin polymerization and is a potent apoptotic inducer in human SK-MEL-1 melanoma cells.

Bioorg Med Chem 2017 11 3;25(21):6060-6070. Epub 2017 Oct 3.

Departamento de Bioquímica y Biología Molecular, Unidad Asociada al Consejo Superior de Investigaciones Científicas (CSIC), Instituto Universitario de Investigaciones Biomédicas y Sanitarias, Universidad de las Palmas de Gran Canaria, Paseo Blas Cabrera Felipe s/n, 35016 Las Palmas de Gran Canaria, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2017.09.043DOI Listing
November 2017

Statistical Analysis of the Main Configuration Parameters of the Network Dynamic and Adaptive Radio Protocol (DARP).

Sensors (Basel) 2017 Jun 26;17(7). Epub 2017 Jun 26.

Department of Computer Architecture and Technology, University of Granada, Periodista Daniel Saucedo Aranda S/N, 18071 Granada, Spain.

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http://dx.doi.org/10.3390/s17071502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5539715PMC
June 2017

Antiproliferative activity and apoptosis induction by 3',4'-dibenzyloxyflavonol on human leukemia cells.

Chem Biol Interact 2017 Apr 22;268:13-23. Epub 2017 Feb 22.

Departamento de Bioquímica y Biología Molecular, Unidad Asociada al Consejo Superior de Investigaciones Científicas (CSIC), Instituto Universitario de Investigaciones Biomédicas y Sanitarias, Universidad de las Palmas de Gran Canaria, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.cbi.2017.02.010DOI Listing
April 2017

mDARAL: A Multi-Radio Version for the DARAL Routing Algorithm.

Sensors (Basel) 2017 Feb 9;17(2). Epub 2017 Feb 9.

Department of Electrical Engineering and Computer Science, University of Applied Sciences of Münster, Stegerwaldstr. 39, D-48565 Steinfurt, Germany.

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http://dx.doi.org/10.3390/s17020324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5336107PMC
February 2017

Melatonin enhances hyperthermia-induced apoptotic cell death in human leukemia cells.

J Pineal Res 2016 Oct 13;61(3):381-95. Epub 2016 Aug 13.

Departamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología, Facultad de Ciencias de la Salud, Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.

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http://dx.doi.org/10.1111/jpi.12356DOI Listing
October 2016

Gardenin B-induced cell death in human leukemia cells involves multiple caspases but is independent of the generation of reactive oxygen species.

Chem Biol Interact 2016 Aug 14;256:220-7. Epub 2016 Jul 14.

Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Investigaciones Biomédicas y Sanitarias, Universidad de Las Palmas de Gran Canaria, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.cbi.2016.07.016DOI Listing
August 2016

DARAL: A Dynamic and Adaptive Routing Algorithm for Wireless Sensor Networks.

Sensors (Basel) 2016 Jun 24;16(7). Epub 2016 Jun 24.

Department of Computer Architecture and Technology, University of Granada, Periodista Daniel Saucedo Aranda, S/N, 18071 Granada, Spain.

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http://dx.doi.org/10.3390/s16070960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970014PMC
June 2016

Sesquiterpenoids Isolated from Two Species of the Asteriscus Alliance.

J Nat Prod 2016 05 4;79(5):1292-7. Epub 2016 May 4.

Instituto de Productos Naturales y Agrobiología-Consejo Superior de Investigaciones Científicas (CSIC) , Avenida Astrofísico Francisco Sánchez 3, 38206 La Laguna, Tenerife, Spain.

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http://dx.doi.org/10.1021/acs.jnatprod.5b01013DOI Listing
May 2016

Assessment of morbidity in gynaecologic oncology laparoscopy and identification of possible risk factors.

Ecancermedicalscience 2015 14;9:606. Epub 2015 Dec 14.

Clinical Epidemiology and Biostatistics Unit, Santiago de Compostela University Clinical Teaching Hospital and Santiago Health Research Institute, Spain.

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http://dx.doi.org/10.3332/ecancer.2015.606DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4679209PMC
December 2015

The abietane diterpenoid parvifloron D from Plectranthus ecklonii is a potent apoptotic inducer in human leukemia cells.

Phytomedicine 2015 Oct 10;22(11):1009-16. Epub 2015 Jul 10.

Department of Biochemistry and Molecular Biology, University of Las Palmas de Gran Canaria, Plaza Dr. Pasteur s/n, 35016 Las Palmas de Gran Canaria, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.phymed.2015.06.013DOI Listing
October 2015

Design, synthesis and antiproliferative activity of novel heterobivalent hybrids based on imidazo[2,1-b][1,3,4]thiadiazole and imidazo[2,1-b][1,3]thiazole scaffolds.

Eur J Med Chem 2015 Aug 25;101:205-17. Epub 2015 Jun 25.

Department of Biochemistry, University of Las Palmas de Gran Canaria, Plaza Dr. Pasteur s/n, 35016 Las Palmas de Gran Canaria, Spain.

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http://dx.doi.org/10.1016/j.ejmech.2015.06.042DOI Listing
August 2015

Eupatorin-induced cell death in human leukemia cells is dependent on caspases and activates the mitogen-activated protein kinase pathway.

PLoS One 2014 12;9(11):e112536. Epub 2014 Nov 12.

Department of Biochemistry and Molecular Biology, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0112536PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229185PMC
July 2015

The eudesmanolide tanapsin from Tanacetum oshanahanii and its acetate induce cell death in human tumor cells through a mechanism dependent on reactive oxygen species.

Phytomedicine 2015 Mar 16;22(3):385-93. Epub 2015 Feb 16.

Department of Biochemistry and Molecular Biology, University of Las Palmas de Gran Canaria, Plaza Dr. Pasteur s/n, 35016 Las Palmas de Gran Canaria, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.phymed.2015.01.008DOI Listing
March 2015

Induction of G2/M phase arrest and apoptosis by the flavonoid tamarixetin on human leukemia cells.

Mol Carcinog 2014 Dec 13;53(12):939-50. Epub 2013 Jun 13.

Department of Biochemistry and Molecular Biology, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain; Instituto Canario de Investigación del Cáncer, Las Palmas de Gran Canaria, Spain.

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http://dx.doi.org/10.1002/mc.22055DOI Listing
December 2014

Synthesis and effects on cell viability of flavonols and 3-methyl ether derivatives on human leukemia cells.

Eur J Med Chem 2014 Sep 4;84:30-41. Epub 2014 Jul 4.

Departamento de Bioquímica y Biología Molecular, Unidad Asociada al Consejo Superior de Investigaciones Científicas (CSIC), Instituto Canario de Investigación del Cáncer, Universidad de Las Palmas de Gran Canaria, Plaza Dr. Pasteur s/n, 35016 Las Palmas de Gran Canaria, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2014.07.010DOI Listing
September 2014

Melatonin induces apoptosis through a caspase-dependent but reactive oxygen species-independent mechanism in human leukemia Molt-3 cells.

J Pineal Res 2013 Sep 1;55(2):195-206. Epub 2013 Jun 1.

Departamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología, Facultad de Ciencias de la Salud, Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.

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http://dx.doi.org/10.1111/jpi.12062DOI Listing
September 2013

A chemotaxonomic study of endemic species of genus Tanacetum from the Canary Islands.

Phytochemistry 2013 Aug 25;92:87-104. Epub 2013 May 25.

Departamento de Química, Unidad Asociada al CSIC, Universidad de Las Palmas de Gran Canaria, Campus de Tafira, 35017 Las Palmas de Gran Canaria, Canary Islands, Spain.

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http://dx.doi.org/10.1016/j.phytochem.2013.04.015DOI Listing
August 2013

Antiproliferative activity of abietane diterpenoids against human tumor cells.

J Nat Prod 2013 Aug 18;76(8):1413-23. Epub 2013 Jul 18.

Departamento de Bioquímica y Biología Molecular, Unidad Asociada al Consejo Superior de Investigaciones Científicas-CSIC, Instituto Canario de Investigación del Cáncer, Universidad de Las Palmas de Gran Canaria, Plaza Dr. Pasteur s/n, 35016 Las Palmas de Gran Canaria, Spain.

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http://dx.doi.org/10.1021/np400172kDOI Listing
August 2013

Anticancer activity of novel hybrid molecules containing 5-benzylidene thiazolidine-2,4-dione.

Eur J Med Chem 2013 May 14;63:544-57. Epub 2013 Mar 14.

Dipartimento di Scienze Chimiche e Farmaceutiche, Università di Ferrara, 44100 Ferrara, Italy.

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http://dx.doi.org/10.1016/j.ejmech.2013.02.030DOI Listing
May 2013

Ayanin diacetate-induced cell death is amplified by TRAIL in human leukemia cells.

Biochem Biophys Res Commun 2012 Nov 11;428(1):116-20. Epub 2012 Oct 11.

Departamento de Bioquímica, Unidad Asociada al Consejo Superior de Investigaciones Científicas, Universidad de Las Palmas de Gran Canaria, Plaza Dr. Pasteur s/n, 35016 Las Palmas de Gran Canaria, Spain.

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http://dx.doi.org/10.1016/j.bbrc.2012.10.017DOI Listing
November 2012

Secondary metabolites from two species of Tolpis and their biological activities.

Molecules 2012 Nov 1;17(11):12895-909. Epub 2012 Nov 1.

Departamento de Química, Unidad Asociada al CSIC, Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.

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http://dx.doi.org/10.3390/molecules171112895DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268065PMC
November 2012

Cell death triggered by synthetic flavonoids in human leukemia cells is amplified by the inhibition of extracellular signal-regulated kinase signaling.

Eur J Med Chem 2012 Sep 27;55:284-96. Epub 2012 Jul 27.

Department of Biochemistry and Molecular Biology, Associated Unit to the Spanish National Research Council (C.S.I.C.), University of Las Palmas de Gran Canaria, Instituto Canario de Investigación del Cáncer, Plaza Dr. Pasteur s/n, 35016 Las Palmas de Gran Canaria, Spain.

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http://dx.doi.org/10.1016/j.ejmech.2012.07.028DOI Listing
September 2012

Effect of C-ring modifications on the cytotoxicity of spirostan saponins and related glycosides.

Bioorg Med Chem 2012 Jul 17;20(14):4522-31. Epub 2012 May 17.

Institute of Pharmacy and Food, University of Havana, San Lázaro y L, 10400 La Habana, Cuba.

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http://dx.doi.org/10.1016/j.bmc.2012.05.018DOI Listing
July 2012

Synthetic menthyl α/β-(1→6)-diglucopyranosides-induced cell death in human leukemia cells is dependent on caspases.

Bioorg Med Chem Lett 2012 Jun 13;22(11):3665-70. Epub 2012 Apr 13.

Departamento de Bioquímica, Unidad Asociada al Consejo Superior de Investigaciones Científicas, Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.

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http://dx.doi.org/10.1016/j.bmcl.2012.04.035DOI Listing
June 2012

New insights into the structure-cytotoxicity relationship of spirostan saponins and related glycosides.

Bioorg Med Chem 2012 Apr 15;20(8):2690-700. Epub 2012 Feb 15.

Instituto de Productos Naturales y Agrobiología-CSIC, Av. Astrofísico Francisco Sánchez 3, 38206 La Laguna, Tenerife, Spain.

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http://dx.doi.org/10.1016/j.bmc.2012.02.026DOI Listing
April 2012

Secondary metabolites from two species of Pulicaria and their cytotoxic activity.

Chem Biodivers 2011 Nov;8(11):2080-9

Departamento de Química, Universidad de Las Palmas de Gran Canaria, Unidad Asociada al CSIC, Campus de Tafira, SP, Las Palmas de Gran Canaria.

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http://dx.doi.org/10.1002/cbdv.201000324DOI Listing
November 2011

Astragalin heptaacetate-induced cell death in human leukemia cells is dependent on caspases and activates the MAPK pathway.

Cancer Lett 2011 Oct 11;309(1):71-7. Epub 2011 Jun 11.

Departamento de Bioquímica, Unidad Asociada al Consejo Superior de Investigaciones Científicas, Universidad de Las Palmas de Gran Canaria, Instituto Canario de Investigación del Cáncer, Plaza Dr. Pasteur s/n, Las Palmas de Gran Canaria, Spain.

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http://dx.doi.org/10.1016/j.canlet.2011.05.018DOI Listing
October 2011

Pregnane steroidal glycosides and their cytostatic activities.

Glycobiology 2011 May 8;21(5):619-24. Epub 2010 Dec 8.

Departamento de Química de Productos Naturales y Biotecnología, Instituto de Productos Naturales y Agrobiología de Canarias, La Laguna, Tenerife, Canary Islands.

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http://dx.doi.org/10.1093/glycob/cwq203DOI Listing
May 2011

5,7,3'-Trihydroxy-3,4'-dimethoxyflavone inhibits the tubulin polymerization and activates the sphingomyelin pathway.

Mol Carcinog 2011 Feb 10;50(2):113-22. Epub 2010 Dec 10.

Department of Biochemistry and Molecular Biology, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.

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http://dx.doi.org/10.1002/mc.20693DOI Listing
February 2011

Mitral valve repair for ischemic mitral regurgitation using the Carpentier-McCarthy-Adams IMR ETlogix® ring: medium-term echocardiographic findings.

Rev Esp Cardiol 2010 Oct;63(10):1200-4

Servicio de Cirugía Cardiaca, Complejo Hospitalario Universitario de A Coruña, A Coruña, España.

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October 2010

Mycotic pseudoaneurysm following a Bentall procedure.

J Card Surg 2010 Sep;25(5):566-7

Department of Cardiothoracic Surgery, Complejo Hospitalario Universitario A Coruña, A Coruña, Spain.

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September 2010

Melatonin decreases cell proliferation and induces melanogenesis in human melanoma SK-MEL-1 cells.

J Pineal Res 2010 Aug 29;49(1):45-54. Epub 2010 Apr 29.

Departamento de Ciencias Clínicas, Facultad de Ciencias de la Salud, Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.

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http://dx.doi.org/10.1111/j.1600-079X.2010.00765.xDOI Listing
August 2010

5,7,3'-trihydroxy-3,4'-dimethoxyflavone-induced cell death in human leukemia cells is dependent on caspases and activates the MAPK pathway.

Mol Carcinog 2010 May;49(5):464-75

Department of Biochemistry and Molecular Biology, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.

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http://dx.doi.org/10.1002/mc.20619DOI Listing
May 2010

Naturally occurring asteriscunolide A induces apoptosis and activation of mitogen-activated protein kinase pathway in human tumor cell lines.

Mol Carcinog 2010 May;49(5):488-99

Department of Biochemistry and Molecular Biology, Instituto Canario de Investigación del Cáncer (ICIC), University of Las Palmas de Gran Canaria, Plaza Dr. Pasteur s/n, Las Palmas de Gran Canaria, Spain.

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http://dx.doi.org/10.1002/mc.20629DOI Listing
May 2010

Chemotaxonomy of Gonospermum and related genera.

Phytochemistry 2010 Apr 22;71(5-6):627-34. Epub 2010 Jan 22.

Departamento de Química, Universidad de Las Palmas de Gran Canaria, Campus de Tafira, 35017 Las Palmas de Gran Canaria, Canary Islands, Spain.

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http://dx.doi.org/10.1016/j.phytochem.2009.12.013DOI Listing
April 2010

Betuletol 3-methyl ether induces G(2)-M phase arrest and activates the sphingomyelin and MAPK pathways in human leukemia cells.

Mol Carcinog 2010 Jan;49(1):32-43

Department of Biochemistry and Molecular Biology, University of Las Palmas de Gran Canaria, Spain.

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http://dx.doi.org/10.1002/mc.20574DOI Listing
January 2010

Chemical constituents of Tolpis species.

Fitoterapia 2009 Oct 11;80(7):437-41. Epub 2009 Jun 11.

Departamento de Química, Universidad de Las Palmas de Gran Canaria, Campus de Tafira, 35017, Las Palmas de Gran Canaria, Gran Canaria, Canary Islands, Spain.

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http://dx.doi.org/10.1016/j.fitote.2009.06.001DOI Listing
October 2009

alpha-Bromoacrylamido N-substituted isatin derivatives as potent inducers of apoptosis in human myeloid leukemia cells.

ChemMedChem 2009 Oct;4(10):1668-76

Dipartimento di Scienze Farmaceutiche, Università di Ferrara, 44100 Ferrara (Italy).

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http://dx.doi.org/10.1002/cmdc.200900245DOI Listing
October 2009

Mid-term results of thoracic endovascular aortic repair in surgical high-risk patients.

Interact Cardiovasc Thorac Surg 2009 Jul 9;9(1):61-5. Epub 2009 Apr 9.

Department of Cardiothoracic Surgery, Juan Canalejo Hospital, La Coruña, Spain.

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http://dx.doi.org/10.1510/icvts.2008.196402DOI Listing
July 2009

Sesquiterpene lactones from Gonospermum gomerae and G. fruticosum and their cytotoxic activities.

J Nat Prod 2008 Dec;71(12):2015-20

Departamento de Química, Universidad de Las Palmas de Gran Canaria, Campus de Tafira, 35017 Las Palmas de Gran Canaria, Canary Islands, Spain.

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http://dx.doi.org/10.1021/np800474vDOI Listing
December 2008

Induction of G2-M phase arrest and apoptosis by alpha-methylene-gamma-butyrolactones in human leukemia cells.

Cancer Lett 2008 Sep 2;269(1):139-47. Epub 2008 Jun 2.

Department of Biochemistry, University of Las Palmas de Gran Canaria, Plaza Dr. Pasteur s/n, 35016 Las Palmas de Gran Canaria, Spain.

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http://dx.doi.org/10.1016/j.canlet.2008.04.028DOI Listing
September 2008

Trifolin acetate-induced cell death in human leukemia cells is dependent on caspase-6 and activates the MAPK pathway.

Apoptosis 2008 May;13(5):716-28

Department of Biochemistry, Instituto Canario de Investigación del Cáncer (I.C.I.C.), University of Las Palmas de Gran Canaria, Plaza Dr. Pasteur s/n, 35016, Las Palmas de Gran Canaria, Spain.

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http://dx.doi.org/10.1007/s10495-008-0202-0DOI Listing
May 2008

Synthesis of novel spirostanic saponins and their cytotoxic activity.

Bioorg Med Chem 2008 Feb 4;16(4):2063-76. Epub 2007 Nov 4.

Instituto de Productos Naturales y Agrobiología-C.S.I.C., Antonio González, Av. Astrofísico F. Sánchez 3, 38206 La Laguna, Tenerife, Spain.

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https://linkinghub.elsevier.com/retrieve/pii/S09680896070095
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http://dx.doi.org/10.1016/j.bmc.2007.10.089DOI Listing
February 2008

Cytotoxic activities of flavonoid glycoside acetates from Consolida oliveriana.

Planta Med 2008 Feb 23;74(2):171-4. Epub 2008 Jan 23.

Instituto Universitario de Bio-Orgánica Antonio González, La Laguna, Tenerife, Spain.

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http://dx.doi.org/10.1055/s-2008-1034278DOI Listing
February 2008

A new ceramide from Suillus luteus and its cytotoxic activity against human melanoma cells.

Chem Biodivers 2008 Jan;5(1):120-5

Instituto de Productos Naturales y Agrobiología, CSIC, Instituto Universitario de Bio-Orgánica Antonio González, Av. Astrofísico F. Sánchez 3, E-38206 La Laguna, Tenerife.

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http://dx.doi.org/10.1002/cbdv.200890002DOI Listing
January 2008

Right counterpulsation?

Eur J Cardiothorac Surg 2007 Nov 5;32(5):797. Epub 2007 Sep 5.

Department of Cardiac Surgery, Juan Canalejo Hospital, A Coruña, Spain.

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http://dx.doi.org/10.1016/j.ejcts.2007.08.007DOI Listing
November 2007

Acetyl derivative of quercetin 3-methyl ether-induced cell death in human leukemia cells is amplified by the inhibition of ERK.

Carcinogenesis 2007 Oct 4;28(10):2105-13. Epub 2007 Jun 4.

Department of Biochemistry, University of Las Palmas de Gran Canaria, Plaza Dr. Pasteur s/n, 35016 Las Palmas de Gran Canaria, Spain.

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http://dx.doi.org/10.1093/carcin/bgm131DOI Listing
October 2007

Inhibition of proliferation and induction of apoptosis by melatonin in human myeloid HL-60 cells.

J Pineal Res 2007 Mar;42(2):131-8

Departamento de Bioquímica, Biología Molecular y Fisiología, Centro de Ciencias de la Salud, Universidad de Las Palmas de Gran Canaria, Spain.

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http://dx.doi.org/10.1111/j.1600-079X.2006.00392.xDOI Listing
March 2007

[Aortic valve replacement with a Cryolife O'Brien stentless bioprosthesis].

Rev Esp Cardiol 2007 Jan;60(1):45-50

Servicio de Cirugía Cardiaca, Hospital Universitario Juan Canalejo, A Coruña, Spain.

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January 2007

Phenylbenzopyrones structure-activity studies identify betuletol derivatives as potential antitumoral agents.

Eur J Pharmacol 2006 Oct 22;548(1-3):9-20. Epub 2006 Jul 22.

Department of Biochemistry, I.C.I.C., University of Las Palmas de Gran Canaria, Plaza Dr. Pasteur s/n, 35016 Las Palmas de Gran Canaria, Spain.

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http://dx.doi.org/10.1016/j.ejphar.2006.07.020DOI Listing
October 2006

Isolation, structure elucidation, total synthesis, and evaluation of new natural and synthetic ceramides on human SK-MEL-1 melanoma cells.

J Med Chem 2006 Sep;49(19):5830-9

Instituto de Productos Naturales y Agrobiología, C.S.I.C., Instituto Universitario de Bio-Organica Antonio Gonzalez, Avda. Astrofísico F. Sanchez 3, 38206 La Laguna, Tenerife, Spain.

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http://dx.doi.org/10.1021/jm0605334DOI Listing
September 2006

A homo-isoflavonoid and a cytotoxic saponin from Dracaena draco.

Chem Biodivers 2006 Jan;3(1):62-8

Instituto de Productos Naturales y Agrobiología-C.S.I.C., Avenida Astrofísico F. Sánchez 3, E-38206 La Laguna, Tenerife.

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http://dx.doi.org/10.1002/cbdv.200690008DOI Listing
January 2006

Sesquiterpenoids from Pulicaria canariensis and their cytotoxic activities.

J Nat Prod 2005 Apr;68(4):523-31

Departamento de Química, Universidad de Las Palmas de Gran Canaria, Campus de Tafira, 35017 Las Palmas de Gran Canaria, Spain.

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http://dx.doi.org/10.1021/np0496183DOI Listing
April 2005

Cladocalol, a pentacyclic 28-nor-triterpene from Eucalyptus cladocalyx with cytotoxic activity.

Phytochemistry 2005 Mar;66(6):627-32

Laboratory of Valorisation of Natural Resources, University of Constantine, Constantine 25000, Algeria.

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http://dx.doi.org/10.1016/j.phytochem.2004.12.018DOI Listing
March 2005

Lanostanoid triterpenes from Laetiporus sulphureus and apoptosis induction on HL-60 human myeloid leukemia cells.

J Nat Prod 2004 Dec;67(12):2008-11

Instituto de Productos Naturales y Agrobiología, CSIC, Instituto Universitario de Bio-Orgánica Antonio González, Avenida Astrofísico F. Sánchez 3, 38206 La Laguna, Tenerife, Spain.

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http://dx.doi.org/10.1021/np049762oDOI Listing
December 2004

Childhood and malaria vaccines combined in biodegradable microspheres produce immunity with synergistic interactions.

J Control Release 2004 Oct;99(3):345-55

Division of Bacteriology, National Institute for Biological Standards and Controls, Blanche Lane, South Mimms, Potters Bar, Hertfordshire EN6 3QG, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S016836590400332
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http://dx.doi.org/10.1016/j.jconrel.2004.07.014DOI Listing
October 2004

Icogenin, a new cytotoxic steroidal saponin isolated from Dracaena draco.

Bioorg Med Chem 2004 Aug;12(16):4423-9

Instituto de Productos Naturales y Agrobiología-CSIC, Instituto Universitario de Bio-Orgánica Antonio González, La Laguna, Tenerife, Spain.

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http://dx.doi.org/10.1016/j.bmc.2004.06.009DOI Listing
August 2004

Isolation from Eucalyptus occidentalis and identification of a new kaempferol derivative that induces apoptosis in human myeloid leukemia cells.

J Nat Prod 2004 Apr;67(4):527-31

Laboratoire de Valorisation des Ressources Naturelles, Université Mentouri, Constantine, Route de Aín El Bey 25000 Constantine, Algeria.

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http://pubs.acs.org/doi/abs/10.1021/np049960f
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http://dx.doi.org/10.1021/np049960fDOI Listing
April 2004

Enantioselective synthesis and biological activity of (3S,4R)- and (3S,4S)-3-hydroxy-4-hydroxymethyl- 4-butanolides in relation to PGE2.

J Med Chem 2004 Jan;47(2):292-5

Instituto Universitario de Bio-Orgánica Antonio González-Instituto de Productos Naturales y Agrobiología-CSIC, Avenida Astrofísico F. Sánchez 3, 38206 La Laguna, Tenerife, Canary Islands, Spain.

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http://dx.doi.org/10.1021/jm034216yDOI Listing
January 2004

Potent induction of apoptosis by germacranolide sesquiterpene lactones on human myeloid leukemia cells.

Eur J Pharmacol 2003 Dec;482(1-3):77-84

Department of Chemistry, University of Las Palmas de Gran Canaria, Edificio Ciencias Básicas, Campus Universitario de Tafira, 35017 Las Palmas de Gran Canaria, Spain.

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December 2003

Melatonin prevents apoptosis and enhances HSP27 mRNA expression induced by heat shock in HL-60 cells: possible involvement of the MT2 receptor.

J Pineal Res 2003 Nov;35(4):231-8

Departamento de Ciencias Clínicas, Biología Molecular y Fisiología, Facultad de Ciencias de la Salud, Universidad de Las Palmas de Gran Canaria, Spain.

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November 2003

Sesquiterpenoid derivatives from Gonospermum elegans and their cytotoxic activity for HL-60 human promyelocytic cells.

J Nat Prod 2003 Jul;66(7):943-8

Departamento de Química, Universidad de Las Palmas de Gran Canaria, Campus de Tafira, 35017 Las Palmas de Gran Canaria, Canary Islands, Spain.

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http://dx.doi.org/10.1021/np020390yDOI Listing
July 2003

Steroidal saponins from the bark of Dracaena draco and their cytotoxic activities.

J Nat Prod 2003 Jun;66(6):793-8

Instituto Universitario de Bio-Orgánica Antonio González, Instituto de Productos Naturales y Agrobiología-CSIC, Avenida Astrofísico F. Sánchez 3, 38206 La Laguna, Tenerife, Spain.

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http://dx.doi.org/10.1021/np020517jDOI Listing
June 2003

New lanostanoids from the fungus Ganoderma concinna.

J Nat Prod 2002 Mar;65(3):417-21

Instituto Universitario de Bio-Orgánica "Antonio González", Instituto de Productos Naturales y Agrobiología.-CSIC, Avenida Astrofísico F. Sánchez 3, 38206 La Laguna, Tenerife, Spain.

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March 2002