Publications



Minimum Information about a Biosynthetic Gene cluster.
Nat Chem Biol 2015 Sep;11(9):625-31
1] Microbial Genomics and Bioinformatics Research Group, Max Planck Institute for Marine Microbiology, Bremen, Germany. [2] Jacobs University Bremen gGmbH, Bremen, Germany.

Insights into the evolution of enzyme substrate promiscuity after the discovery of (βα)₈ isomerase evolutionary intermediates from a diverse metagenome.
BMC Evol Biol 2015 Jun 10;15:107. Epub 2015 Jun 10.
Evolution of Metabolic Diversity, Unidad de Genómica Avanzada (Langebio), Cinvestav-IPN, Km 9.6 Libramiento Norte, Carretera Irapuato - León, CP 36821, Irapuato, México.

Molecular annotation of ketol-acid reductoisomerases from Streptomyces reveals a novel amino acid biosynthesis interlock mediated by enzyme promiscuity.
Microb Biotechnol 2015 Mar 9;8(2):239-52. Epub 2014 Oct 9.
Evolution of Metabolic Diversity Laboratory, Unidad de Genómica Avanzada (Langebio), Cinvestav-IPN, Km 9.6 Libramiento Norte, Irapuato, Guanajuato, CP36822, México.

Promiscuous and adaptable enzymes fill "holes" in the tetrahydrofolate pathway in Chlamydia species.
MBio 2014 Jul 8;5(4):e01378-14. Epub 2014 Jul 8.
Department of Microbiology and Immunology, F. Edward Hébert School of Medicine, Uniformed Services University, Bethesda, Maryland, USA

First draft genome sequence of a strain from the genus Citricoccus.
J Bacteriol 2011 Nov;193(21):6092-3
Centro de Investigación y Estudios Avanzados, Laboratorio Nacional de Genómica para la Biodiversidad (LANGEBIO), Km. 9.6 Libramiento Norte Carretera Irapuato-León, Apdo. Postal 629, Irapuato 36821, Guanajuato, Mexico.

Exploring the Structure-Function Loop Adaptability of a (β/α)(8)-Barrel Enzyme through Loop Swapping and Hinge Variability.
J Mol Biol 2011 Aug 27;411(1):143-57. Epub 2011 May 27.
Departamento de Ingeniería Celular y Biocatálisis, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Avenida Universidad 2001, Cuernavaca, C.P. 62210, México.

Disruption of the siderophore-binding desE receptor gene in Streptomyces coelicolor A3(2) results in impaired growth in spite of multiple iron-siderophore transport systems.
Microb Biotechnol 2011 Mar 10;4(2):275-85. Epub 2011 Jan 10.
Evolution of Metabolic Diversity Laboratory, Laboratorio Nacional de Genómica para la Biodiversidad (Langebio), CINVESTAV-IPN, Km 9.6 Libramiento Norte, Carretera Irapuato-León, Irapuato, C.P. 36822, México.

Identification and analysis of residues contained on beta --> alpha loops of the dual-substrate (beta alpha)8 phosphoribosyl isomerase A specific for its phosphoribosyl anthranilate isomerase activity.
Protein Sci 2010 Mar;19(3):535-43
Evolution of Metabolic Diversity Laboratory, Laboratorio Nacional de Genómica para la Biodiversidad (Langebio), CINVESTAV-IPN, Km 9.6 Libramiento Norte, Carretera Irapuato-León, Irapuato, C.P. 36822, México.





OF