Francisca Vazquez

Francisca Vazquez

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Francisca Vazquez

Francisca Vazquez

Publications by authors named "Francisca Vazquez"

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66Publications

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Synthetic Lethal Interaction of SHOC2 Depletion with MEK Inhibition in RAS-Driven Cancers.

Cell Rep 2019 Oct;29(1):118-134.e8

Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, MA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.08.090DOI Listing
October 2019

Interrogation of Mammalian Protein Complex Structure, Function, and Membership Using Genome-Scale Fitness Screens.

Cell Syst 2018 05 16;6(5):555-568.e7. Epub 2018 May 16.

Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA; Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA 02142, USA; Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S24054712183018
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http://dx.doi.org/10.1016/j.cels.2018.04.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152908PMC
May 2018

Functional Genomic Characterization of Cancer Genomes.

Cold Spring Harb Symp Quant Biol 2016 4;81:237-246. Epub 2016 Nov 4.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02215.

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http://dx.doi.org/10.1101/sqb.2016.81.031070DOI Listing
February 2018

PRMT1-Mediated Translation Regulation Is a Crucial Vulnerability of Cancer.

Cancer Res 2017 09 27;77(17):4613-4625. Epub 2017 Jun 27.

Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/0008-5472.CAN-17-0216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5581676PMC
September 2017

Defining a Cancer Dependency Map.

Cell 2017 Jul;170(3):564-576.e16

Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA, USA; Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, USA; Department of Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, USA; Harvard Medical School, 25 Shattuck Street, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.06.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5667678PMC
July 2017

Complementary information derived from CRISPR Cas9 mediated gene deletion and suppression.

Nat Commun 2017 05 23;8:15403. Epub 2017 May 23.

Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, Massachusetts 02142, USA.

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http://dx.doi.org/10.1038/ncomms15403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457492PMC
May 2017

A PGC1α-mediated transcriptional axis suppresses melanoma metastasis.

Nature 2016 09 31;537(7620):422-426. Epub 2016 Aug 31.

Department of Cancer Biology, Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nature19347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5161587PMC
September 2016

Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting.

Cancer Discov 2016 08 3;6(8):914-29. Epub 2016 Jun 3.

Dana-Farber Cancer Institute, Boston, Massachusetts. Broad Institute of Harvard and MIT, Cambridge, Massachusetts. Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts. Harvard Medical School, Boston, Massachusetts. Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, Massachusetts.

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http://dx.doi.org/10.1158/2159-8290.CD-16-0154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972686PMC
August 2016

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.

Sci Data 2014 30;1:140035. Epub 2014 Sep 30.

Broad Institute of Harvard and MIT, 7 Cambridge Center , Cambridge, Massachusetts 02142, USA ; Department of Medical, Dana-Farber Cancer Institute , 450 Brookline Avenue, Boston, Massachusetts 02215, USA ; Center for Cancer Genome Discovery, Dana-Farber Cancer Institute , 450 Brookline Avenue, Boston, Massachusetts 02215, USA ; Departments of Medicine, Brigham and Women's Hospital, Harvard Medical School , Boston, Massachusetts 02115, USA.

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http://www.nature.com/articles/sdata201435
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http://dx.doi.org/10.1038/sdata.2014.35DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432652PMC
February 2016

Identification of an "Exceptional Responder" Cell Line to MEK1 Inhibition: Clinical Implications for MEK-Targeted Therapy.

Mol Cancer Res 2016 Feb 18;14(2):207-15. Epub 2015 Nov 18.

Broad Institute of Harvard and MIT, Cambridge, Massachusetts. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts. Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, Massachusetts. Department of Pathology, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1541-7786.MCR-15-0321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755909PMC
February 2016

Targeting mitochondrial oxidative metabolism in melanoma causes metabolic compensation through glucose and glutamine utilization.

Cancer Res 2014 Jul 8;74(13):3535-45. Epub 2014 May 8.

Authors' Affiliations: Department of Cancer Biology, Dana-Farber Cancer Institute; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts; and

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http://dx.doi.org/10.1158/0008-5472.CAN-13-2893-TDOI Listing
July 2014

Cyclin D1-Cdk4 controls glucose metabolism independently of cell cycle progression.

Nature 2014 Jun 25;510(7506):547-51. Epub 2014 May 25.

1] Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA [2] Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nature13267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076706PMC
June 2014

Residual complexes containing SMARCA2 (BRM) underlie the oncogenic drive of SMARCA4 (BRG1) mutation.

Mol Cell Biol 2014 Mar 13;34(6):1136-44. Epub 2014 Jan 13.

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1128/MCB.01372-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958034PMC
March 2014

ARID1B is a specific vulnerability in ARID1A-mutant cancers.

Nat Med 2014 Mar 23;20(3):251-4. Epub 2014 Feb 23.

1] Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA. [2] Division of Hematology/Oncology, Boston Children's Hospital, Boston, Massachusetts, USA. [3] Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA. [4] Broad Institute of Harvard and MIT, Boston, Massachusetts, USA. [5] Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nm.3480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954704PMC
March 2014

Evaluation of Circulating Tumor Cells and Related Events as Prognostic Factors and Surrogate Biomarkers in Advanced NSCLC Patients Receiving First-Line Systemic Treatment.

Cancers (Basel) 2014 Jan 21;6(1):153-65. Epub 2014 Jan 21.

Translational Medical Oncology, Health Research Institute of Santiago (IDIS), Complexo Hospitalario Universitario de Santiago de Compostela (SERGAS), Trav. Choupana s/n 15706 Santiago de Compostela, Spain.

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http://dx.doi.org/10.3390/cancers6010153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3980598PMC
January 2014

Systematic interrogation of 3q26 identifies TLOC1 and SKIL as cancer drivers.

Cancer Discov 2013 Sep 13;3(9):1044-57. Epub 2013 Jun 13.

1Departments of Medical Oncology and 2Cancer Biology; 3Center for Cancer Genome Discovery, Dana-Farber Cancer Institute;4Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston; 5Broad Institute of Harvard and MIT, Cambridge, Massachusetts; and 6Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina.

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http://dx.doi.org/10.1158/2159-8290.CD-12-0592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770815PMC
September 2013

PGC1α expression defines a subset of human melanoma tumors with increased mitochondrial capacity and resistance to oxidative stress.

Cancer Cell 2013 Mar 14;23(3):287-301. Epub 2013 Feb 14.

Department of Cancer Biology, Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.ccr.2012.11.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708305PMC
March 2013

Glycine decarboxylase cleaves a "malignant" metabolic path to promote tumor initiation.

Cancer Cell 2012 Feb;21(2):143-5

Department of Cancer Biology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.ccr.2012.01.019DOI Listing
February 2012

A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN.

Proc Natl Acad Sci U S A 2009 Jan 29;106(2):480-5. Epub 2008 Dec 29.

Departments of Cell Biology and Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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http://www.pnas.org/content/early/2008/12/29/0811212106.full
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http://www.pnas.org/cgi/doi/10.1073/pnas.0811212106
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http://dx.doi.org/10.1073/pnas.0811212106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2626728PMC
January 2009

mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex.

Nature 2007 Nov;450(7170):736-40

Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nature06322DOI Listing
November 2007

Regulation of PTEN function as a PIP3 gatekeeper through membrane interaction.

Cell Cycle 2006 Jul 17;5(14):1523-7. Epub 2006 Jul 17.

Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.4161/cc.5.14.3005DOI Listing
July 2006

Nap1 regulates Dictyostelium cell motility and adhesion through SCAR-dependent and -independent pathways.

Curr Biol 2006 Apr;16(7):717-22

School of Biosciences, University of Birmingham, Edgbaston, UK.

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http://dx.doi.org/10.1016/j.cub.2006.02.068DOI Listing
April 2006

Tumor suppressor PTEN acts through dynamic interaction with the plasma membrane.

Proc Natl Acad Sci U S A 2006 Mar 28;103(10):3633-8. Epub 2006 Feb 28.

Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1073/pnas.0510570103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1450134PMC
March 2006

Temporal and spatial regulation of phosphoinositide signaling mediates cytokinesis.

Dev Cell 2005 Apr;8(4):467-77

Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1016/j.devcel.2005.02.010DOI Listing
April 2005

High tumor incidence and activation of the PI3K/AKT pathway in transgenic mice define AIB1 as an oncogene.

Cancer Cell 2004 Sep;6(3):263-74

Division of Molecular and Cellular Oncology, Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.ccr.2004.06.027DOI Listing
September 2004

Novel mechanism of PTEN regulation by its phosphatidylinositol 4,5-bisphosphate binding motif is critical for chemotaxis.

J Biol Chem 2004 Apr 5;279(16):16606-13. Epub 2004 Feb 5.

Department of Cell Biology, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1074/jbc.M312098200DOI Listing
April 2004

TSC2 regulates VEGF through mTOR-dependent and -independent pathways.

Cancer Cell 2003 Aug;4(2):147-58

Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA.

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August 2003