Francis J Hornicek

Francis J Hornicek

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Francis J Hornicek

Francis J Hornicek

Publications by authors named "Francis J Hornicek"

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Emerging next-generation sequencing-based discoveries for targeted osteosarcoma therapy.

Cancer Lett 2020 Apr 24;474:158-167. Epub 2020 Jan 24.

Department of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, 90095, USA. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2020.01.020DOI Listing
April 2020

Chimeric antigen receptor T (CAR-T) cell immunotherapy for sarcomas: From mechanisms to potential clinical applications.

Cancer Treat Rev 2020 Jan 25;82:101934. Epub 2019 Nov 25.

Department of Orthopedic Surgery, Sarcoma Biology Laboratory, David Geffen School of Medicine, University of California, Los Angeles, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ctrv.2019.101934DOI Listing
January 2020

Giants of Orthopaedic Surgery: Henry J. Mankin MD.

Clin Orthop Relat Res 2019 Dec;477(12):2647

F. J. Hornicek, Chair, Department of Orthopaedic Surgery at University of California at Los Angeles, Los Angeles, CA, USA.

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http://dx.doi.org/10.1097/CORR.0000000000001018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6907308PMC
December 2019

Establishment and Characterization of a Recurrent Osteosarcoma Cell Line: OSA 1777.

J Orthop Res 2019 Nov 18. Epub 2019 Nov 18.

Department of Orthopedic Surgery, Sarcoma Biology Laboratory, David Geffen School of Medicine, University of California, Los Angeles, California.

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http://dx.doi.org/10.1002/jor.24528DOI Listing
November 2019

Association between patient age and the risk of mortality following local recurrence of a sacral chordoma.

J Surg Oncol 2019 Nov 22. Epub 2019 Nov 22.

University Musculoskeletal Oncology Unit, Division of Orthopaedic Surgery, Department of Surgery, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1002/jso.25774DOI Listing
November 2019

Cancer Testis Antigens in Sarcoma: Expression, Function and Immunotherapeutic Application.

Cancer Lett 2019 Oct 18. Epub 2019 Oct 18.

Department of Orthopedic Surgery, Sarcoma Biology Laboratory, David Geffen School of Medicine at UCLA, 615 Charles E. Young Dr. South, Los Angeles, CA, 90095, USA. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2019.10.024DOI Listing
October 2019

Radiation-induced and neurofibromatosis-associated malignant peripheral nerve sheath tumors (MPNST) have worse outcomes than sporadic MPNST.

Radiother Oncol 2019 08 9;137:61-70. Epub 2019 May 9.

Department of Radiation Oncology, Massachusetts General Hospital, Boston, USA; Harvard Medical School, Boston, USA. Electronic address:

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http://dx.doi.org/10.1016/j.radonc.2019.03.015DOI Listing
August 2019

Exosomes promote pre-metastatic niche formation in ovarian cancer.

Mol Cancer 2019 08 13;18(1):124. Epub 2019 Aug 13.

Department of Obstetrics and Gynecology, The First Affiliated Hospital of Zhengzhou University, 1 Jianshe East Road, Zhengzhou, 450052, Henan, China.

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http://dx.doi.org/10.1186/s12943-019-1049-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691526PMC
August 2019

Low dose radiotherapy is associated with local complications but not disease control in sacral chordoma.

J Surg Oncol 2019 Jun 7;119(7):856-863. Epub 2019 Feb 7.

Division of Orthopaedic Surgery, Department of Surgery, University Musculoskeletal Oncology Unit Mount Sinai Hospital, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1002/jso.25399DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746225PMC
June 2019

Sacral chordoma: a clinical review of 101 cases with 30-year experience in a single institution.

Spine J 2019 05 14;19(5):869-879. Epub 2018 Nov 14.

Department of Orthopaedic Surgery, Orthopaedic Oncology Service, Massachusetts General Hospital - Harvard Medical School, 55 Fruit St, Boston, MA 02114, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S15299430183120
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http://dx.doi.org/10.1016/j.spinee.2018.11.002DOI Listing
May 2019

Cyclin-dependent kinase 9 (CDK9) is a novel prognostic marker and therapeutic target in ovarian cancer.

FASEB J 2019 May 6;33(5):5990-6000. Epub 2019 Feb 6.

Department of Obstetrics and Gynecology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

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https://www.fasebj.org/doi/10.1096/fj.201801789RR
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http://dx.doi.org/10.1096/fj.201801789RRDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463912PMC
May 2019

Advances in immune checkpoint inhibitors for bone sarcoma therapy.

J Bone Oncol 2019 Apr 29;15:100221. Epub 2019 Jan 29.

Department of Orthopedic Surgery, Sarcoma Biology Laboratory, David Geffen School of Medicine, University of California, 615 Charles E. Young. Dr. South, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1016/j.jbo.2019.100221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365405PMC
April 2019

Targeting mutant TP53 as a potential therapeutic strategy for the treatment of osteosarcoma.

J Orthop Res 2019 03 12;37(3):789-798. Epub 2019 Feb 12.

Sarcoma Biology Laboratory, Department of Orthopaedic Surgery, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California, 90095.

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http://doi.wiley.com/10.1002/jor.24227
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http://dx.doi.org/10.1002/jor.24227DOI Listing
March 2019

Targeting regulation of cyclin dependent kinase 9 as a novel therapeutic strategy in synovial sarcoma.

J Orthop Res 2019 02 3;37(2):510-521. Epub 2019 Jan 3.

Sarcoma Biology Laboratory, Department of Orthopaedic Surgery, David Geffen School of Medicine at University of California Los Angeles, 615 Charles E. Young Dr. S., Los Angeles, California, 90095.

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http://dx.doi.org/10.1002/jor.24189DOI Listing
February 2019

Complications and reoperations after surgery for 647 patients with spine metastatic disease.

Spine J 2019 01 1;19(1):144-156. Epub 2018 Jun 1.

Department of Orthopaedic Surgery, Orthopaedic Oncology Service, Massachusetts General Hospital-Harvard Medical School, 55 Fruit St, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.spinee.2018.05.037DOI Listing
January 2019

RNA sequencing (RNA-Seq) and its application in ovarian cancer.

Gynecol Oncol 2019 01 5;152(1):194-201. Epub 2018 Oct 5.

Department of Obstetrics and Gynecology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China; Department of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00908258183128
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http://dx.doi.org/10.1016/j.ygyno.2018.10.002DOI Listing
January 2019

Cyclin-dependent kinase 9 (CDK9) is a novel prognostic marker and therapeutic target in osteosarcoma.

EBioMedicine 2019 Jan 20;39:182-193. Epub 2018 Dec 20.

Sarcoma Biology Laboratory, Department of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2018.12.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355967PMC
January 2019

From genomics to metabolomics: emerging metastatic biomarkers in osteosarcoma.

Cancer Metastasis Rev 2018 12;37(4):719-731

Department of Orthopaedic Surgery, Sarcoma Biology Laboratory, David Geffen School of Medicine at UCLA, 615 Charles E. Young Dr. S, Los Angeles, CA, 90095, USA.

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http://dx.doi.org/10.1007/s10555-018-9763-8DOI Listing
December 2018

Application of liquid biopsy in bone and soft tissue sarcomas: Present and future.

Cancer Lett 2018 12 14;439:66-77. Epub 2018 Sep 14.

Sarcoma Biology Laboratory, Department of Orthopaedic Surgery, David Geffen School of Medicine at University of Los Angeles, Los Angeles, CA, 90095, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03043835183056
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http://dx.doi.org/10.1016/j.canlet.2018.09.012DOI Listing
December 2018

Clinicopathologic characteristics of poorly differentiated chordoma.

Mod Pathol 2018 08 26;31(8):1237-1245. Epub 2018 Feb 26.

Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA, 02114, USA.

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http://dx.doi.org/10.1038/s41379-018-0002-1DOI Listing
August 2018

Expression and Clinical Implication of Autophagy-Associated Protein p62 in Osteosarcoma.

Oncology 2018 4;95(1):52-60. Epub 2018 Apr 4.

Department of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.

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http://dx.doi.org/10.1159/000487437DOI Listing
July 2018

CRISPR-Cas9-Mediated Silencing of CD44 in Human Highly Metastatic Osteosarcoma Cells.

Cell Physiol Biochem 2018 16;46(3):1218-1230. Epub 2018 Apr 16.

Sarcoma Biology Laboratory, Department of Orthopaedic Surgery, David Geffen School of Medicine at University of Los Angeles, Los Angeles, California, USA.

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http://dx.doi.org/10.1159/000489072DOI Listing
July 2018

Expression and role of autophagy-associated p62 (SQSTM1) in multidrug resistant ovarian cancer.

Gynecol Oncol 2018 07 24;150(1):143-150. Epub 2018 Apr 24.

Department of Obstetrics and Gynecology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China; Department of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ygyno.2018.04.557DOI Listing
July 2018

CDK4 expression in chordoma: A potential therapeutic target.

J Orthop Res 2018 06 22;36(6):1581-1589. Epub 2017 Dec 22.

UCLA Orthopaedic Surgery, Sarcoma Biology Laboratory, 615 Charles E Young Dr. South, Biomedical Sciences Research Building, Room 410, Los Angeles, CA 90095.

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http://dx.doi.org/10.1002/jor.23819DOI Listing
June 2018

Lower Extremity Megaprostheses in Orthopaedic Oncology.

J Am Acad Orthop Surg 2018 Jun;26(12):e249-e257

From the Department of Orthopaedic Surgery, Orthopaedic Oncology Service, Massachusetts General Hospital, Harvard Medical School, Boston, MA (Dr. Lozano Calderón, Dr. Kuechle, and Dr. Raskin) and the Department of Orthopaedic Surgery, Ronald Reagan UCLA Medical Center, Santa Monica, CA (Dr. Hornicek).

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http://Insights.ovid.com/crossref?an=00124635-201806150-0000
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http://dx.doi.org/10.5435/JAAOS-D-16-00218DOI Listing
June 2018

Henry J. Mankin: A Trailblazer in Skeletal Pathology Research.

Spine (Phila Pa 1976) 2018 Jun 8. Epub 2018 Jun 8.

UCLA Health, Department of Orthopaedic Surgery, Santa Monica, CA.

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http://dx.doi.org/10.1097/BRS.0000000000002730DOI Listing
June 2018

Expression and therapeutic implications of cyclin-dependent kinase 4 (CDK4) in osteosarcoma.

Biochim Biophys Acta Mol Basis Dis 2018 May 13;1864(5 Pt A):1573-1582. Epub 2018 Feb 13.

Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, People's Republic of China; Sarcoma Biology Laboratory, UCLA Orthopaedic Surgery, Los Angeles, CA 90095, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2018.02.004DOI Listing
May 2018

HER4 promotes cell survival and chemoresistance in osteosarcoma via interaction with NDRG1.

Biochim Biophys Acta Mol Basis Dis 2018 May 8;1864(5 Pt A):1839-1849. Epub 2018 Mar 8.

Department of Orthopedics, Shanghai General Hospital, School of Medicine Shanghai Jiao Tong University, Shanghai, China; Shanghai Bone Tumor Institution, Shanghai, China. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2018.03.008DOI Listing
May 2018

Inhibition of cyclin-dependent kinase 4 as a potential therapeutic strategy for treatment of synovial sarcoma.

Cell Death Dis 2018 05 1;9(5):446. Epub 2018 May 1.

Sarcoma Biology Laboratory, Department of Orthopaedic Surgery, David Geffen School of Medicine at University of Los Angeles, Los Angeles, CA, 90095, USA.

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http://dx.doi.org/10.1038/s41419-018-0474-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5906661PMC
May 2018

Synovial sarcoma of the shoulder: A series of 14 cases.

J Surg Oncol 2018 Mar 22;117(4):788-796. Epub 2017 Nov 22.

Department of Orthopaedic Surgery, Musculoskeletal Oncology Service, Massachusetts General Hospital-Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1002/jso.24889DOI Listing
March 2018

What Is the Effect of High-dose Radiation on Bone in Patients With Sacral Chordoma? A CT Study.

Clin Orthop Relat Res 2018 03;476(3):520-528

O. van Wulfften Palthe, Massachusetts General Hospital, Boston, MA, USA K.-W. Jee, Y.-L. E. Chen, Department of Radiation Oncology, Massachusetts General Hospital-Harvard Medical School, Boston, MA, USA J. A. M. Bramer, Department of Orthopaedic Surgery, Academic Medical Center, Amsterdam, Amsterdam, The Netherlands F. J. Hornicek, Harvard Medical School, Orthopaedic Oncology Service, Massachusetts General Hospital-Harvard Medical School, Boston, MA, USA J. H. Schwab, Department of Orthopaedic Surgery, Orthopaedic Oncology Service, Spine Surgery Service, Massachusetts General Hospital-Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1007/s11999.0000000000000063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260039PMC
March 2018

Targeting DYRK1B suppresses the proliferation and migration of liposarcoma cells.

Oncotarget 2018 Mar 28;9(17):13154-13166. Epub 2017 Nov 28.

Department of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-6902, USA.

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http://dx.doi.org/10.18632/oncotarget.22743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862568PMC
March 2018

Immune Surveillance Plays a Role in Locally Aggressive Giant Cell Lesions of Bone.

Clin Orthop Relat Res 2017 Dec 19;475(12):3071-3081. Epub 2017 Jul 19.

Department of Orthopaedic Surgery, Massachusetts General Hospital-Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA.

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http://dx.doi.org/10.1007/s11999-017-5451-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5670060PMC
December 2017

Primary arthroplasty in healed osteoarticular allograft in patients with history of primary femoral bone tumors.

Surg Oncol 2017 Dec 5;26(4):498-505. Epub 2017 Oct 5.

Department of Orthopedic Surgery, Orthopedic Oncology Service, Massachusetts General Hospital, Harvard Medical School, United States; Beth Israel Deaconess Medical Center, Harvard Medical School, United States.

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http://dx.doi.org/10.1016/j.suronc.2017.10.003DOI Listing
December 2017

Expression and Therapeutic Potential of SOX9 in Chordoma.

Clin Cancer Res 2017 Sep 12;23(17):5176-5186. Epub 2017 Jun 12.

Sarcoma Biology Laboratory, Department of Orthopaedic Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-0177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5581713PMC
September 2017

Modified En Bloc Spondylectomy for Tumors of the Thoracic and Lumbar Spine: Surgical Technique and Outcomes.

J Bone Joint Surg Am 2017 Sep;99(17):1476-1484

1Department of Orthopaedic Surgery, Massachusetts General Hospital, Boston, Massachusetts 2Division of Thoracic Surgery, St. Elizabeth's Medical Center, Brighton, Massachusetts 3Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY.

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http://dx.doi.org/10.2106/JBJS.17.00141DOI Listing
September 2017

Regulation of microRNAs function by circular RNAs in human cancer.

Oncotarget 2017 Sep 4;8(38):64622-64637. Epub 2017 Aug 4.

Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, P.R. China.

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http://dx.doi.org/10.18632/oncotarget.19930DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610031PMC
September 2017

Noncoding RNA in drug resistant sarcoma.

Oncotarget 2017 Sep 6;8(40):69086-69104. Epub 2017 Jul 6.

Sarcoma Biology Laboratory, Department of Orthopaedic Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, 02114, USA.

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http://dx.doi.org/10.18632/oncotarget.19029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620323PMC
September 2017

Most efficient questionnaires to measure quality of life, physical function, and pain in patients with metastatic spine disease: a cross-sectional prospective survey study.

Spine J 2017 07 24;17(7):953-961. Epub 2017 Feb 24.

Department of Orthopaedic Surgery, Orthopaedic Oncology Service, Massachusetts General Hospital-Harvard Medical School, 55 Fruit St, Boston, MA 02114, USA.

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http://dx.doi.org/10.1016/j.spinee.2017.02.006DOI Listing
July 2017

Aberration of Promoter Methylation in Chondrosarcoma.

Anticancer Res 2017 06;37(6):2939-2945

Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, U.S.A.

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http://ar.iiarjournals.org/content/37/6/2939.abstract
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http://dx.doi.org/10.21873/anticanres.11647DOI Listing
June 2017

What questionnaires to use when measuring quality of life in sacral tumor patients: the updated sacral tumor survey.

Spine J 2017 05 14;17(5):636-644. Epub 2016 Nov 14.

Department of Orthopaedic Surgery, Orthopaedic Oncology Service, Massachusetts General Hospital - Harvard Medical School, Room 3.946, Yawkey Building, 55 Fruit St, Boston, MA 02114, USA.

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http://dx.doi.org/10.1016/j.spinee.2016.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5539909PMC
May 2017

Wnt inhibitory factor 1 (WIF1) methylation and its association with clinical prognosis in patients with chondrosarcoma.

Sci Rep 2017 05 8;7(1):1580. Epub 2017 May 8.

Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.

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http://dx.doi.org/10.1038/s41598-017-01763-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431504PMC
May 2017

How Does the Level of Nerve Root Resection in En Bloc Sacrectomy Influence Patient-Reported Outcomes?

Clin Orthop Relat Res 2017 Mar;475(3):607-616

Orthopaedic Oncology Service, Department of Orthopaedic Surgery, Massachusetts General Hospital-Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1007/s11999-016-4794-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289168PMC
March 2017

Facial Layer-by-Layer Engineering of Upconversion Nanoparticles for Gene Delivery: Near-Infrared-Initiated Fluorescence Resonance Energy Transfer Tracking and Overcoming Drug Resistance in Ovarian Cancer.

ACS Appl Mater Interfaces 2017 Mar 21;9(9):7941-7949. Epub 2017 Feb 21.

Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University , Boston, Massachusetts 02115, United States.

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http://dx.doi.org/10.1021/acsami.6b15321DOI Listing
March 2017

Genetic Analysis of Giant Cell Lesions of the Maxillofacial and Axial/Appendicular Skeletons.

J Oral Maxillofac Surg 2017 Feb 26;75(2):298-308. Epub 2016 Jul 26.

Walter Guralnik Distinguished Professor, Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital and Harvard School of Dental Medicine, Boston, MA.

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http://dx.doi.org/10.1016/j.joms.2016.07.014DOI Listing
February 2017

Regulation of microRNA-1 (miR-1) expression in human cancer.

Biochim Biophys Acta Gene Regul Mech 2017 Feb 5;1860(2):227-232. Epub 2016 Dec 5.

Department of Pharmacy, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, PR China; Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbagrm.2016.12.004DOI Listing
February 2017

Updated Outcome and Analysis of Tumor Response in Mobile Spine and Sacral Chordoma Treated With Definitive High-Dose Photon/Proton Radiation Therapy.

Int J Radiat Oncol Biol Phys 2017 02 13;97(2):254-262. Epub 2016 Oct 13.

Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.ijrobp.2016.10.006DOI Listing
February 2017

miR-15b modulates multidrug resistance in human osteosarcoma in vitro and in vivo.

Mol Oncol 2017 02 24;11(2):151-166. Epub 2016 Oct 24.

Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, MA, USA.

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http://doi.wiley.com/10.1002/1878-0261.12015
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http://dx.doi.org/10.1002/1878-0261.12015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5300234PMC
February 2017

Novel mechanisms and approaches to overcome multidrug resistance in the treatment of ovarian cancer.

Biochim Biophys Acta 2016 12 4;1866(2):266-275. Epub 2016 Oct 4.

Department of Gynecologic Oncology, The First Affiliated Hospital of Zhengzhou University, 1 Jianshe East Road, Zhengzhou 450052, People's Republic of China; Sarcoma Biology Laboratory, Department of Orthopaedic Surgery, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Jackson 1115, Boston, MA 02114, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bbcan.2016.10.001DOI Listing
December 2016

Clinical outcomes for patients after surgery and radiation therapy for mesenchymal chondrosarcomas.

J Surg Oncol 2016 Dec 28;114(8):982-986. Epub 2016 Oct 28.

Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1002/jso.24435DOI Listing
December 2016

Targeting ABCB1 (MDR1) in multi-drug resistant osteosarcoma cells using the CRISPR-Cas9 system to reverse drug resistance.

Oncotarget 2016 Dec;7(50):83502-83513

Sarcoma Biology Laboratory, Department of Orthopaedic surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.18632/oncotarget.13148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347784PMC
December 2016

Are perioperative allogeneic blood transfusions associated with 90-days infection after operative treatment for bone metastases?

J Surg Oncol 2016 Dec 18;114(8):997-1003. Epub 2016 Nov 18.

Department of Orthopaedic Surgery, Orthopaedic Oncology Service, Massachusetts General Hospital-Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1002/jso.24440DOI Listing
December 2016

A comparison of questionnaires for assessing physical function in patients with lower extremity bone metastases.

J Surg Oncol 2016 Nov 11;114(6):691-696. Epub 2016 Aug 11.

Department of Orthopaedic Surgery, Orthopaedic Oncology Service, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1002/jso.24400DOI Listing
November 2016

Aberrant DNA methylations in chondrosarcoma.

Epigenomics 2016 11 30;8(11):1519-1525. Epub 2016 Sep 30.

Sarcoma Biology Laboratory, Department of Orthopaedic Surgery, Massachusetts General Hospital & Harvard Medical School, 55 Fruit Street, Jackson 1115, Boston, MA 02114, USA.

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http://dx.doi.org/10.2217/epi-2016-0071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289043PMC
November 2016

Development of a Prognostic Survival Algorithm for Patients with Metastatic Spine Disease.

J Bone Joint Surg Am 2016 Nov;98(21):1767-1776

Department of Orthopaedic Surgery, Orthopaedic Oncology Service, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts

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http://dx.doi.org/10.2106/JBJS.15.00975DOI Listing
November 2016

Primary intra-articular sarcoma: a clinicopathological study of 15 cases.

Histopathology 2016 Oct 19;69(4):614-23. Epub 2016 May 19.

James Homer Wright Pathology Laboratories, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1111/his.12978DOI Listing
October 2016

Evaluation of P-glycoprotein (Pgp) expression in human osteosarcoma by high-throughput tissue microarray.

J Orthop Res 2016 09 2;34(9):1606-12. Epub 2016 Feb 2.

Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, 02114.

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http://dx.doi.org/10.1002/jor.23173DOI Listing
September 2016

Outcome after fixation of metastatic proximal femoral fractures: A systematic review of 40 studies.

J Surg Oncol 2016 Sep 3;114(4):507-19. Epub 2016 Jul 3.

Department of Orthopaedic Surgery, Orthopaedic Oncology Service Boston, Massachusetts General Hospital-Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1002/jso.24345DOI Listing
September 2016

The Discrepancy between Patient and Clinician Reported Function in Extremity Bone Metastases.

Sarcoma 2016 20;2016:1014248. Epub 2016 Sep 20.

Department of Orthopaedic Surgery, Orthopaedic Oncology Service, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5048023PMC
http://dx.doi.org/10.1155/2016/1014248DOI Listing
September 2016

Polymeric nanoparticle-based delivery of microRNA-199a-3p inhibits proliferation and growth of osteosarcoma cells.

Int J Nanomedicine 2015 15;10:2913-24. Epub 2015 Apr 15.

Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.2147/IJN.S79143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404938PMC
August 2016

Are allogeneic blood transfusions associated with decreased survival after surgical treatment for spinal metastases?

Spine J 2016 08 24;16(8):951-61. Epub 2016 Mar 24.

Department of Orthopaedic Surgery, Orthopaedic Oncology Service, Massachusetts General Hospital-Harvard Medical School, Room 3.946, Yawkey Building, 55 Fruit St, Boston, MA 02114, USA.

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http://dx.doi.org/10.1016/j.spinee.2016.03.043DOI Listing
August 2016

The experience of accommodating privacy restrictions during implementation of a large-scale surveillance study of an osteoporosis medication.

Pharmacoepidemiol Drug Saf 2016 08 19;25(8):960-8. Epub 2016 Apr 19.

Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1002/pds.4008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5074316PMC
August 2016

Metastasectomy, intralesional resection, or stabilization only in the treatment of bone metastases from renal cell carcinoma.

J Surg Oncol 2016 Aug 9;114(2):237-45. Epub 2016 May 9.

Department of Orthopaedic Surgery, Orthopaedic Oncology Service, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1002/jso.24284DOI Listing
August 2016

CASE RECORDS of the MASSACHUSETTS GENERAL HOSPITAL. Case 26-2016. A 28-Year-Old Woman with Back Pain and a Lesion in the Lumbar Spine.

N Engl J Med 2016 Aug;375(8):779-88

From the Department of Medicine, Division of Hematology-Oncology (E.C.), and the Departments of Orthopedic Surgery (F.J.H.), Radiation Oncology (Y.-L.C.), Radiology (D.I.R.), and Pathology (D.A.K.), Massachusetts General Hospital, and the Departments of Medicine (E.C.), Orthopedic Surgery (F.J.H.), Radiation Oncology (Y.-L.C.), Radiology (D.I.R.), and Pathology (D.A.K.), Harvard Medical School - both in Boston.

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http://dx.doi.org/10.1056/NEJMcpc1505482DOI Listing
August 2016

Cyclin-Dependent Kinase 11 (CDK11) Is Required for Ovarian Cancer Cell Growth In Vitro and In Vivo, and Its Inhibition Causes Apoptosis and Sensitizes Cells to Paclitaxel.

Mol Cancer Ther 2016 07 20;15(7):1691-701. Epub 2016 May 20.

Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1535-7163.MCT-16-0032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936930PMC
July 2016

Complications After Surgical Management of Proximal Femoral Metastasis: A Retrospective Study of 417 Patients.

J Am Acad Orthop Surg 2016 Jul;24(7):483-94

From the Department of Orthopaedic Surgery, Massachusetts General Hospital, Boston, MA.

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http://dx.doi.org/10.5435/JAAOS-D-16-00043DOI Listing
July 2016

The roles and therapeutic potential of cyclin-dependent kinases (CDKs) in sarcoma.

Cancer Metastasis Rev 2016 06;35(2):151-63

Department of Orthopaedic Surgery, Sarcoma Biology Laboratory, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Jackson 1115, Boston, MA, 02114, USA.

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http://dx.doi.org/10.1007/s10555-015-9601-1DOI Listing
June 2016

CSPG4 as a prognostic biomarker in chordoma.

Spine J 2016 06 9;16(6):722-7. Epub 2015 Dec 9.

Department of Orthopaedic Surgery, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, Boston, MA 02114, USA.

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http://dx.doi.org/10.1016/j.spinee.2015.11.059DOI Listing
June 2016

The emerging roles and therapeutic potential of cyclin-dependent kinase 11 (CDK11) in human cancer.

Oncotarget 2016 Jun;7(26):40846-40859

Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, People's Republic of China.

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http://dx.doi.org/10.18632/oncotarget.8519DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5130049PMC
June 2016

Pharmacokinetics and tolerability of NSC23925b, a novel P-glycoprotein inhibitor: preclinical study in mice and rats.

Sci Rep 2016 05 9;6:25659. Epub 2016 May 9.

Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1038/srep25659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4860631PMC
May 2016

Prognostic factors in alveolar soft part sarcoma: A SEER analysis.

J Surg Oncol 2016 Apr 25;113(5):581-6. Epub 2016 Jan 25.

Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1002/jso.24183DOI Listing
April 2016

Development and potential applications of CRISPR-Cas9 genome editing technology in sarcoma.

Cancer Lett 2016 Apr 21;373(1):109-118. Epub 2016 Jan 21.

Sarcoma Biology Laboratory, Department of Orthopaedic Surgery, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Jackson 1115, Boston, MA 02114, United States. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2016.01.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772675PMC
April 2016

Targeting EZH2-mediated methylation of H3K27 inhibits proliferation and migration of Synovial Sarcoma in vitro.

Sci Rep 2016 04 29;6:25239. Epub 2016 Apr 29.

Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, United States.

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http://dx.doi.org/10.1038/srep25239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850444PMC
April 2016

Sacral Insufficiency Fractures are Common After High-dose Radiation for Sacral Chordomas Treated With or Without Surgery.

Clin Orthop Relat Res 2016 Mar 23;474(3):766-72. Epub 2015 Sep 23.

Department of Orthopaedic Surgery, Orthopaedic Oncology Service, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114, USA.

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http://dx.doi.org/10.1007/s11999-015-4566-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746193PMC
March 2016

Complications after surgery for metastatic humeral lesions.

J Shoulder Elbow Surg 2016 Feb 5;25(2):207-15. Epub 2015 Nov 5.

Department of Orthopaedic Surgery, Orthopaedic Oncology Service, Massachusetts General Hospital-Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.jse.2015.08.009DOI Listing
February 2016

NVP-TAE684 reverses multidrug resistance (MDR) in human osteosarcoma by inhibiting P-glycoprotein (PGP1) function.

Br J Pharmacol 2016 Feb 15;173(3):613-26. Epub 2016 Jan 15.

Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1111/bph.13395DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728419PMC
February 2016

Targeting protein kinases to reverse multidrug resistance in sarcoma.

Cancer Treat Rev 2016 Feb 8;43:8-18. Epub 2015 Dec 8.

Sarcoma Biology Laboratory, Department of Orthopaedic Surgery, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Jackson 1115, Boston, MA 02114, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ctrv.2015.11.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735639PMC
February 2016

Characteristics and Patterns of Metastatic Disease from Chordoma.

Sarcoma 2015 30;2015:517657. Epub 2015 Dec 30.

Department of Orthopedic Surgery, Massachusetts General Hospital, Harvard Medical School, Orthopaedic Associates, 55 Fruit Street Yawkey 3B, Boston, MA 02114, USA.

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http://dx.doi.org/10.1155/2015/517657DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4710904PMC
February 2016

Denosumab-treated Giant Cell Tumor of Bone Exhibits Morphologic Overlap With Malignant Giant Cell Tumor of Bone.

Am J Surg Pathol 2016 Jan;40(1):72-80

*Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA †Department of Pathology, Miller School of Medicine, Jackson Memorial Hospital, University of Miami, Miami, FL ‡Department of Radiology §Department of Medicine, Division of Oncology ∥Department of Orthopaedics ¶Department of Pathology, Massachusetts General Hospital, Boston, MA.

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http://pdfs.journals.lww.com/ajsp/2016/01000/Denosumab_treat
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http://dx.doi.org/10.1097/PAS.0000000000000506DOI Listing
January 2016

Surgical management of Gorham-Stout disease of the pelvis refractory to medical and radiation therapy.

Am J Orthop (Belle Mead NJ) 2015 Nov;44(11):E473-7

Department of Orthopaedic Surgery, Rush University Medical Center/Midwest Orthopedics at Rush, Chicago, IL.

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November 2015

The emerging roles and therapeutic potential of microRNAs (miRs) in liposarcoma.

Discov Med 2015 Nov;20(111):311-24

Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

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November 2015

Nsc23925 prevents the development of paclitaxel resistance by inhibiting the introduction of P-glycoprotein and enhancing apoptosis.

Int J Cancer 2015 Oct 5;137(8):2029-39. Epub 2015 May 5.

Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1002/ijc.29574DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529776PMC
October 2015

2015 Marshall Urist Young Investigator Award: Prognostication in Patients With Long Bone Metastases: Does a Boosting Algorithm Improve Survival Estimates?

Clin Orthop Relat Res 2015 Oct 9;473(10):3112-21. Epub 2015 Jul 9.

Department of Orthopaedic Surgery, Orthopaedic Oncology Service, Massachusetts General Hospital-Harvard Medical School, Boston, MA, USA,

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http://dx.doi.org/10.1007/s11999-015-4446-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562931PMC
October 2015

Spinal Cord Blood Supply and Its Surgical Implications.

J Am Acad Orthop Surg 2015 Oct 16;23(10):581-91. Epub 2015 Sep 16.

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http://dx.doi.org/10.5435/JAAOS-D-14-00219DOI Listing
October 2015

Paget Disease of Bone.

Orthop Clin North Am 2015 Oct;46(4):577-85

Orthopaedic Oncology Service, Department of Orthopaedic Surgery, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA; Orthopaedic Oncology Service, Department of Orthopaedic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00305898150008
Publisher Site
http://dx.doi.org/10.1016/j.ocl.2015.06.008DOI Listing
October 2015

Percutaneous Acetabuloplasty Compared With Open Reconstruction for Extensive Periacetabular Carcinoma Metastases.

J Arthroplasty 2015 Sep 27;30(9):1586-91. Epub 2015 Feb 27.

Massachusetts General Hospital, Harvard Combined Department of Orthopedics, Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.arth.2015.02.022DOI Listing
September 2015

Rhabdomyosarcoma: Advances in Molecular and Cellular Biology.

Sarcoma 2015 1;2015:232010. Epub 2015 Sep 1.

Department of Orthopaedic Surgery, Massachusetts General Hospital, 100 Blossom Street, Boston, MA 02114, USA ; Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, 100 Blossom Street, Boston, MA 02114, USA.

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http://dx.doi.org/10.1155/2015/232010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569767PMC
September 2015

Quality of life after en bloc resection of tumors in the mobile spine.

Spine J 2015 Aug 8;15(8):1728-37. Epub 2015 Apr 8.

Harvard Combined Department of Orthopedics, Massachusetts General Hospital Department of Orthopedic Surgery, 55 Fruit Street, Boston, MA 02114, USA.

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http://dx.doi.org/10.1016/j.spinee.2015.03.042DOI Listing
August 2015

CD44 is a direct target of miR-199a-3p and contributes to aggressive progression in osteosarcoma.

Sci Rep 2015 Jun 16;5:11365. Epub 2015 Jun 16.

Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.

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http://www.nature.com/articles/srep11365
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http://dx.doi.org/10.1038/srep11365DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468826PMC
June 2015

Up-regulation of CD44 in the development of metastasis, recurrence and drug resistance of ovarian cancer.

Oncotarget 2015 Apr;6(11):9313-26

Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496219PMC
http://dx.doi.org/10.18632/oncotarget.3220DOI Listing
April 2015

MicroRNA-155 expression is independently predictive of outcome in chordoma.

Oncotarget 2015 Apr;6(11):9125-39

Sarcoma Biology Laboratory, Department of Orthopaedic Surgery, Massachusetts General Hospital, Boston, MA 02114, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496207PMC
http://dx.doi.org/10.18632/oncotarget.3273DOI Listing
April 2015