Publications by authors named "Francis J Hornicek"

266 Publications

Targeting cancer stem cells by disulfiram and copper sensitizes radioresistant chondrosarcoma to radiation.

Cancer Lett 2021 Feb 11. Epub 2021 Feb 11.

Division of Surgical Oncology, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA. Electronic address:

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February 2021

Prognostic Significance of Cyclin E1 Expression in Patients With Chordoma: A Clinicopathological and Immunohistochemical Study.

Front Oncol 2020 17;10:596330. Epub 2020 Nov 17.

Sarcoma Biology Laboratory, Department of Orthopedic Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States.

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November 2020

Inhibition of ATR-Chk1 signaling blocks DNA double-strand-break repair and induces cytoplasmic vacuolization in metastatic osteosarcoma.

Ther Adv Med Oncol 2020 14;12:1758835920956900. Epub 2020 Sep 14.

Sarcoma Biology Laboratory, Department of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, 615 Charles E. Young Dr. S., Los Angeles, CA 90095, USA.

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September 2020

T-LAK cell-originated protein kinase (TOPK) is a Novel Prognostic and Therapeutic Target in Chordoma.

Cell Prolif 2020 Oct 22;53(10):e12901. Epub 2020 Sep 22.

Department of Orthopedic Surgery, Sarcoma Biology Laboratory, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.

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October 2020

Expression and clinical implications of leucine-rich repeat containing 15 (LRRC15) in osteosarcoma.

J Orthop Res 2020 11 19;38(11):2362-2372. Epub 2020 Sep 19.

Department of Orthopedic Surgery, Sarcoma Biology Laboratory, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.

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November 2020

The role of extracelluar matrix in osteosarcoma progression and metastasis.

J Exp Clin Cancer Res 2020 Sep 4;39(1):178. Epub 2020 Sep 4.

Department of Orthopedic Surgery, Sarcoma Biology Laboratory, David Geffen School of Medicine at UCLA, 615 Charles E. Young Dr. South, Los Angeles, CA, 90095, USA.

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September 2020

Cyclin-dependent kinase 12 (CDK12) in chordoma: prognostic and therapeutic value.

Eur Spine J 2020 12 20;29(12):3214-3228. Epub 2020 Jul 20.

Department of Orthopaedic Surgery, Sarcoma Biology Laboratory, David Geffen School of Medicine, University of California, Los Angeles, 615 Charles E. Young. Dr. South, Los Angeles, CA, 90095, USA.

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December 2020

Myc is a prognostic biomarker and potential therapeutic target in osteosarcoma.

Ther Adv Med Oncol 2020 10;12:1758835920922055. Epub 2020 May 10.

Department of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, 615 Charles, E. Young. Dr. South, Los Angeles, CA 90095, USA.

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May 2020

Corrigendum to "HER4 promotes cell survival and chemoresistance in osteosarcoma via interaction with NDRG1" [Biochim. Biophys. Acta Mol. Basis Dis. 1864 (2018) 1839-1849].

Biochim Biophys Acta Mol Basis Dis 2020 Jun 13;1866(6):165755. Epub 2020 Mar 13.

Department of Orthopedics, Shanghai General Hospital, School of Medicine Shanghai Jiao Tong University, Shanghai, China; Shanghai Bone Tumor Institution, Shanghai, China. Electronic address:

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June 2020

Cyclin E1 is a prognostic biomarker and potential therapeutic target in osteosarcoma.

J Orthop Res 2020 09 23;38(9):1952-1964. Epub 2020 Mar 23.

Department of Orthopedic Surgery, Sarcoma Biology Laboratory, David Geffen School of Medicine at UCLA, Los Angeles, California.

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September 2020

Surgical treatment of metastatic spine disease: an update on national trends and clinical outcomes from 2010 to 2014.

Spine J 2020 Jun 19;20(6):915-924. Epub 2020 Feb 19.

Department of Orthopedic Surgery, David Geffen School of Medicine at the University of California Los Angeles, 1250 16th St Suite 3142, Santa Monica, Los Angeles, CA, USA. Electronic address:

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June 2020

Emerging next-generation sequencing-based discoveries for targeted osteosarcoma therapy.

Cancer Lett 2020 04 24;474:158-167. Epub 2020 Jan 24.

Department of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, 90095, USA. Electronic address:

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April 2020

Chimeric antigen receptor T (CAR-T) cell immunotherapy for sarcomas: From mechanisms to potential clinical applications.

Cancer Treat Rev 2020 Jan 25;82:101934. Epub 2019 Nov 25.

Department of Orthopedic Surgery, Sarcoma Biology Laboratory, David Geffen School of Medicine, University of California, Los Angeles, CA, USA. Electronic address:

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January 2020

Giants of Orthopaedic Surgery: Henry J. Mankin MD.

Clin Orthop Relat Res 2019 Dec;477(12):2647

F. J. Hornicek, Chair, Department of Orthopaedic Surgery at University of California at Los Angeles, Los Angeles, CA, USA.

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December 2019

Association between patient age and the risk of mortality following local recurrence of a sacral chordoma.

J Surg Oncol 2019 Nov 22. Epub 2019 Nov 22.

University Musculoskeletal Oncology Unit, Division of Orthopaedic Surgery, Department of Surgery, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada.

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November 2019

Establishment and Characterization of a Recurrent Osteosarcoma Cell Line: OSA 1777.

J Orthop Res 2020 04 26;38(4):902-910. Epub 2019 Nov 26.

Department of Orthopedic Surgery, Sarcoma Biology Laboratory, David Geffen School of Medicine, University of California, Los Angeles, California.

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April 2020

Cancer testis antigens in sarcoma: Expression, function and immunotherapeutic application.

Cancer Lett 2020 06 18;479:54-60. Epub 2019 Oct 18.

Department of Orthopedic Surgery, Sarcoma Biology Laboratory, David Geffen School of Medicine at UCLA, 615 Charles E. Young Dr. South, Los Angeles, CA, 90095, USA. Electronic address:

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June 2020

Exosomes promote pre-metastatic niche formation in ovarian cancer.

Mol Cancer 2019 08 13;18(1):124. Epub 2019 Aug 13.

Department of Obstetrics and Gynecology, The First Affiliated Hospital of Zhengzhou University, 1 Jianshe East Road, Zhengzhou, 450052, Henan, China.

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August 2019

Advances in immune checkpoint inhibitors for bone sarcoma therapy.

J Bone Oncol 2019 Apr 29;15:100221. Epub 2019 Jan 29.

Department of Orthopedic Surgery, Sarcoma Biology Laboratory, David Geffen School of Medicine, University of California, 615 Charles E. Young. Dr. South, Los Angeles, CA 90095, USA.

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April 2019

Low dose radiotherapy is associated with local complications but not disease control in sacral chordoma.

J Surg Oncol 2019 Jun 7;119(7):856-863. Epub 2019 Feb 7.

Division of Orthopaedic Surgery, Department of Surgery, University Musculoskeletal Oncology Unit Mount Sinai Hospital, University of Toronto, Toronto, Canada.

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June 2019

Cyclin-dependent kinase 9 (CDK9) is a novel prognostic marker and therapeutic target in ovarian cancer.

FASEB J 2019 05 6;33(5):5990-6000. Epub 2019 Feb 6.

Department of Obstetrics and Gynecology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

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May 2019

Targeting mutant TP53 as a potential therapeutic strategy for the treatment of osteosarcoma.

J Orthop Res 2019 03 12;37(3):789-798. Epub 2019 Feb 12.

Sarcoma Biology Laboratory, Department of Orthopaedic Surgery, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California, 90095.

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March 2019

Cyclin-dependent kinase 9 (CDK9) is a novel prognostic marker and therapeutic target in osteosarcoma.

EBioMedicine 2019 Jan 20;39:182-193. Epub 2018 Dec 20.

Sarcoma Biology Laboratory, Department of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. Electronic address:

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January 2019