Publications by authors named "Francesco Forconi"

100Publications

Guideline for diagnosis and management of hairy cell leukaemia (HCL) and hairy cell variant (HCL-V).

Authors:
Nilima Parry-Jones Anurag Joshi Francesco Forconi Claire Dearden

Br J Haematol 2020 Oct 14. Epub 2020 Oct 14.

Department of Haematology, Royal Marsden NHS Trust, London, UK.

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October 2020

Changes in Bcl-2 members in response to ibrutinib or venetoclax uncover functional hierarchy in determining resistance to venetoclax in CLL.

Authors:
Marco Vincent Haselager Karoline Kielbassa Johanna Ter Burg Danique Johanna Cornelia Bax Stacey Marie Fernandes Jannie Borst Constantine Tam Francesco Forconi Giorgia Chiodin Jennifer R Brown Julie Dubois Arnon P Kater Eric Eldering

Blood 2020 Jun 30. Epub 2020 Jun 30.

Lymphoma and Myeloma Center Amsterdam, LYMMCARE, Netherlands.

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June 2020

International prognostic score for asymptomatic early-stage chronic lymphocytic leukemia.

Authors:
Adalgisa Condoluci Lodovico Terzi di Bergamo Petra Langerbeins Manuela A Hoechstetter Carmen D Herling Lorenzo De Paoli Julio Delgado Kari G Rabe Massimo Gentile Michael Doubek Francesca R Mauro Giorgia Chiodin Mattias Mattsson Jasmin Bahlo Giovanna Cutrona Jana Kotaskova Clara Deambrogi Karin E Smedby Valeria Spina Alessio Bruscaggin Wei Wu Riccardo Moia Elena Bianchi Bernhard Gerber Emanuele Zucca Silke Gillessen Michele Ghielmini Franco Cavalli Georg Stussi Mark A Hess Tycho S Baumann Antonino Neri Manlio Ferrarini Richard Rosenquist Francesco Forconi Robin Foà Sarka Pospisilova Fortunato Morabito Stephan Stilgenbauer Hartmut Döhner Sameer A Parikh William G Wierda Emili Montserrat Gianluca Gaidano Michael Hallek Davide Rossi

Blood 2020 May;135(21):1859-1869

Institute of Oncology Research, Università della Svizzera Italiana, Bellinzona, Switzerland.

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May 2020

IGHV sequencing reveals acquired N-glycosylation sites as a clonal and stable event during follicular lymphoma evolution.

Authors:
Mariette Odabashian Emanuela Carlotti Shamzah Araf Jessica Okosun Filomena Spada John G Gribben Francesco Forconi Freda K Stevenson Mariarita Calaminici Sergey Krysov

Blood 2020 03;135(11):834-844

Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom; and.

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March 2020

Acalabrutinib monotherapy in patients with Waldenström macroglobulinemia: a single-arm, multicentre, phase 2 study.

Authors:
Roger G Owen Helen McCarthy Simon Rule Shirley D'Sa Sheeba K Thomas Olivier Tournilhac Francesco Forconi Marie José Kersten Pier Luigi Zinzani Sunil Iyengar Jaimal Kothari Monique C Minnema Efstathios Kastritis Thérèse Aurran-Schleinitz Bruce D Cheson Harriet Walter Daniel Greenwald Dih-Yih Chen Melanie M Frigault Ahmed Hamdy Raquel Izumi Priti Patel Helen Wei Sun Ku Lee Diana Mittag Richard R Furman

Lancet Haematol 2020 Feb 19;7(2):e112-e121. Epub 2019 Dec 19.

Weill Cornell Medical College, New York Presbyterian Hospital, New York, NY, USA.

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February 2020

Correction: Bidirectional linkage between the B-cell receptor and NOTCH1 in chronic lymphocytic leukemia and in Richter's syndrome: therapeutic implications.

Authors:
Francesca Arruga Valeria Bracciamà Nicoletta Vitale Tiziana Vaisitti Katiuscia Gizzi Alison Yeomans Marta Coscia Giovanni D'Arena Gianluca Gaidano John N Allan Richard R Furman Graham Packham Francesco Forconi Silvia Deaglio

Leukemia 2020 Jun;34(6):1721

Department of Medical Sciences, University of Turin, Turin, Italy.

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June 2020

Preclinical Evaluation of a Novel SHIP1 Phosphatase Activator for Inhibition of PI3K Signaling in Malignant B Cells.

Authors:
Elizabeth A Lemm Beatriz Valle-Argos Lindsay D Smith Johanna Richter Yohannes Gebreselassie Matthew J Carter Jana Karolova Michael Svaton Karel Helman Nicola J Weston-Bell Laura Karydis Chris T Williamson Georg Lenz Jeremy Pettigrew Curtis Harwig Freda K Stevenson Mark Cragg Francesco Forconi Andrew J Steele Jennifer Cross Lloyd Mackenzie Pavel Klener Graham Packham

Clin Cancer Res 2020 04 12;26(7):1700-1711. Epub 2019 Dec 12.

Cancer Research UK Centre, Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.

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April 2020

Integrative analysis of spontaneous CLL regression highlights genetic and microenvironmental interdependency in CLL.

Authors:
Marwan Kwok Ceri Oldreive Andy C Rawstron Anshita Goel Grigorios Papatzikas Rhiannon E Jones Samantha Drennan Angelo Agathanggelou Archana Sharma-Oates Paul Evans Edward Smith Surita Dalal Jingwen Mao Robert Hollows Naheema Gordon Mayumi Hamada Nicholas J Davies Helen Parry Andrew D Beggs Talha Munir Paul Moreton Shankara Paneesha Guy Pratt A Malcolm R Taylor Francesco Forconi Duncan M Baird Jean-Baptiste Cazier Paul Moss Peter Hillmen Tatjana Stankovic

Blood 2020 02;135(6):411-428

Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom.

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February 2020

The efficacy and safety of venetoclax therapy in elderly patients with relapsed, refractory chronic lymphocytic leukaemia.

Authors:
Toby A Eyre Lindsey E Roeker Christopher P Fox Satyen H Gohill Renata Walewska Harriet S Walter Francesco Forconi Angus Broom Arvind Arumainathan Danielle M Brander John N Allan Stephen J Schuster Brian T Hill Frederick Lansigan Bruce D Cheson Nicole Lamanna Catherine C Coombs Paul M Barr Alan P Skarbnik Mazyar Shadman Chaitra S Ujjani Laurie Pearson John M Pagel Ryan Jacobs Anthony R Mato

Br J Haematol 2020 03 4;188(6):918-923. Epub 2019 Nov 4.

Leukemia Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.

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March 2020

Bidirectional linkage between the B-cell receptor and NOTCH1 in chronic lymphocytic leukemia and in Richter's syndrome: therapeutic implications.

Authors:
Francesca Arruga Valeria Bracciamà Nicoletta Vitale Tiziana Vaisitti Katiuscia Gizzi Alison Yeomans Marta Coscia Giovanni D'Arena Gianluca Gaidano John N Allan Richard R Furman Graham Packham Francesco Forconi Silvia Deaglio

Leukemia 2020 02 29;34(2):462-477. Epub 2019 Aug 29.

Department of Medical Sciences, University of Turin, Turin, Italy.

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February 2020

BCR signaling contributes to autophagy regulation in chronic lymphocytic leukemia.

Authors:
Lindsay D Smith Annabel R Minton Matthew D Blunt Laura I Karydis David A Dutton Karly-Rai Rogers-Broadway Rachel Dobson Rena Liu Faith Norster Elizabeth Hogg Margaret Ashton-Key Jonathan C Strefford Li Jia Dimitar G Efremov G Vignir Helgason Peter W M Johnson Freda K Stevenson Francesco Forconi Mark S Cragg David A Tumbarello Graham Packham Andrew J Steele

Leukemia 2020 02 28;34(2):640-644. Epub 2019 Aug 28.

Cancer Sciences, University of Southampton, Southampton General Hospital, Somers Cancer Sciences Building, Southampton, SO16 6YD, UK.

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February 2020

Biological and clinical implications of mutations in chronic lymphocytic leukemia.

Authors:
Fary Diop Riccardo Moia Chiara Favini Elisa Spaccarotella Lorenzo De Paoli Alessio Bruscaggin Valeria Spina Lodovico Terzi-di-Bergamo Francesca Arruga Chiara Tarantelli Clara Deambrogi Silvia Rasi Ramesh Adhinaveni Andrea Patriarca Simone Favini Sruthi Sagiraju Clive Jabangwe Ahad A Kodipad Denise Peroni Francesca R Mauro Ilaria Del Giudice Francesco Forconi Agostino Cortelezzi Francesco Zaja Riccardo Bomben Francesca Maria Rossi Carlo Visco Annalisa Chiarenza Gian Matteo Rigolin Roberto Marasca Marta Coscia Omar Perbellini Alessandra Tedeschi Luca Laurenti Marina Motta David Donaldson Phil Weir Ken Mills Patrick Thornton Sarah Lawless Francesco Bertoni Giovanni Del Poeta Antonio Cuneo Antonia Follenzi Valter Gattei Renzo Luciano Boldorini Mark Catherwood Silvia Deaglio Robin Foà Gianluca Gaidano Davide Rossi

Haematologica 2020 31;105(2):448-456. Epub 2020 Jan 31.

Institute of Oncology Research and Oncology Institute of Southern Switzerland, Bellinzona, Switzerland

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January 2020

Ibrutinib Plus Venetoclax in Relapsed/Refractory Chronic Lymphocytic Leukemia: The CLARITY Study.

Authors:
Peter Hillmen Andy C Rawstron Kristian Brock Samuel Muñoz-Vicente Francesca J Yates Rebecca Bishop Rebecca Boucher Donald MacDonald Christopher Fegan Alison McCaig Anna Schuh Andrew Pettitt John G Gribben Piers E M Patten Stephen Devereux Adrian Bloor Christopher P Fox Francesco Forconi Talha Munir

J Clin Oncol 2019 10 11;37(30):2722-2729. Epub 2019 Jul 11.

St James's Institute of Oncology, Leeds, United Kingdom.

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October 2019

Hedgehog activation in CLL.

Authors:
Giorgia Chiodin Francesco Forconi

Blood 2019 06;133(25):2628-2630

University of Southampton.

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June 2019

Efficacy of venetoclax monotherapy in patients with relapsed chronic lymphocytic leukaemia in the post-BCR inhibitor setting: a UK wide analysis.

Authors:
Toby A Eyre Amy A Kirkwood Sat Gohill George Follows Renata Walewska Harriet Walter Matthew Cross Francesco Forconi Nimish Shah Richard Chasty Alistair Hart Angus Broom Helen Marr Piers E M Patten Andy Dann Arvind Arumainathan Tal Munir Paneesha Shankara Adrian Bloor Rosalynd Johnston Kim Orchard Anna H Schuh Christopher P Fox

Br J Haematol 2019 05 15;185(4):656-669. Epub 2019 Feb 15.

Department of Haematology, Nottingham University Hospitals NHS Trust, Nottingham, UK.

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May 2019

Genome-wide promoter methylation of hairy cell leukemia.

Authors:
Alberto J Arribas Andrea Rinaldi Giorgia Chiodin Ivo Kwee Afua Adjeiwaa Mensah Luciano Cascione Davide Rossi Meena Kanduri Richard Rosenquist Emanuele Zucca Peter W Johnson Gianluca Gaidano Christopher C Oakes Francesco Bertoni Francesco Forconi

Blood Adv 2019 02;3(3):384-396

Cancer Sciences Unit, Cancer Research UK and NIHR Experimental Cancer Medicine Centres, University of Southampton, Southampton, United Kingdom.

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February 2019

Ibrutinib Therapy Releases Leukemic Surface IgM from Antigen Drive in Chronic Lymphocytic Leukemia Patients.

Authors:
Samantha Drennan Giorgia Chiodin Annalisa D'Avola Ian Tracy Peter W Johnson Livio Trentin Andrew J Steele Graham Packham Freda K Stevenson Francesco Forconi

Clin Cancer Res 2019 Apr 29;25(8):2503-2512. Epub 2018 Oct 29.

Cancer Sciences Unit, Cancer Research UK and NIHR Experimental Cancer Medicine Centres, University of Southampton, Southampton, United Kingdom.

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April 2019

Shaving Is an Epiphenomenon of Type I and II Anti-CD20-Mediated Phagocytosis, whereas Antigenic Modulation Limits Type I Monoclonal Antibody Efficacy.

Authors:
Lekh N Dahal Chie-Yin Huang Richard J Stopforth Abbie Mead Keith Chan Juliet X Bowater Martin C Taylor Priyanka Narang H T Claude Chan Jinny H Kim Andrew T Vaughan Francesco Forconi Stephen A Beers

J Immunol 2018 08 11;201(4):1211-1221. Epub 2018 Jul 11.

Antibody and Vaccine Group, Centre for Cancer Immunology, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, United Kingdom; and

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August 2018

Five years of ibrutinib in CLL.

Authors:
Francesco Forconi

Blood 2018 05;131(21):2280-2281

Southampton University Hospital Trust; University of Southampton.

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May 2018

Efficacy of bendamustine and rituximab as first salvage treatment in chronic lymphocytic leukemia and indirect comparison with ibrutinib: a GIMEMA, ERIC and UK CLL FORUM study.

Authors:
Antonio Cuneo George Follows Gian Matteo Rigolin Alfonso Piciocchi Alessandra Tedeschi Livio Trentin Angeles Medina Perez Marta Coscia Luca Laurenti Gerardo Musuraca Lucia Farina Alfredo Rivas Delgado Ester Maria Orlandi Piero Galieni Francesca Romana Mauro Carlo Visco Angela Amendola Atto Billio Roberto Marasca Annalisa Chiarenza Vittorio Meneghini Fiorella Ilariucci Monia Marchetti Stefano Molica Francesca Re Gianluca Gaidano Marcos Gonzalez Francesco Forconi Stefania Ciolli Agostino Cortelezzi Marco Montillo Lukas Smolej Anna Schuh Toby A Eyre Ben Kennedy Kris M Bowles Marco Vignetti Javier de la Serna Carol Moreno Robin Foà Paolo Ghia

Haematologica 2018 07 19;103(7):1209-1217. Epub 2018 Apr 19.

Division of Experimental Oncology, IRCCS San Raffaele Scientific Institute and Vita-Salute San Raffaele University, Milan, Italy.

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July 2018

Increased SHISA3 expression characterizes chronic lymphocytic leukemia patients sensitive to lenalidomide.

Authors:
Rossana Maffei Stefania Fiorcari Silvia Martinelli Stefania Benatti Jenny Bulgarelli Lara Rizzotto Giulia Debbia Rita Santachiara Gian Matteo Rigolin Francesco Forconi Davide Rossi Luca Laurenti Giuseppe A Palumbo Daniele Vallisa Antonio Cuneo Gianluca Gaidano Mario Luppi Roberto Marasca

Leuk Lymphoma 2018 02 22;59(2):423-433. Epub 2017 Jun 22.

a Division of Hematology, Department of Medical and Surgical Sciences , University of Modena and Reggio Emilia , Modena , Italy.

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February 2018

Immunoglobulin genes in chronic lymphocytic leukemia: key to understanding the disease and improving risk stratification.

Authors:
Lesley-Ann Sutton Anastasia Hadzidimitriou Panagiotis Baliakas Andreas Agathangelidis Anton W Langerak Stephan Stilgenbauer Sarka Pospisilova Zadie Davis Francesco Forconi Frederic Davi Paolo Ghia Richard Rosenquist Kostas Stamatopoulos

Haematologica 2017 06;102(6):968-971

Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Sweden.

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June 2017

STING Activation Reverses Lymphoma-Mediated Resistance to Antibody Immunotherapy.

Authors:
Lekh N Dahal Lang Dou Khiyam Hussain Rena Liu Alexander Earley Kerry L Cox Salome Murinello Ian Tracy Francesco Forconi Andrew J Steele Patrick J Duriez Diego Gomez-Nicola Jessica L Teeling Martin J Glennie Mark S Cragg Stephen A Beers

Cancer Res 2017 07 16;77(13):3619-3631. Epub 2017 May 16.

Antibody & Vaccine Group, Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, United Kingdom.

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July 2017

Consensus guidelines for the diagnosis and management of patients with classic hairy cell leukemia.

Authors:
Michael R Grever Omar Abdel-Wahab Leslie A Andritsos Versha Banerji Jacqueline Barrientos James S Blachly Timothy G Call Daniel Catovsky Claire Dearden Judit Demeter Monica Else Francesco Forconi Alessandro Gozzetti Anthony D Ho James B Johnston Jeffrey Jones Gunnar Juliusson Eric Kraut Robert J Kreitman Loree Larratt Francesco Lauria Gerard Lozanski Emili Montserrat Sameer A Parikh Jae H Park Aaron Polliack Graeme R Quest Kanti R Rai Farhad Ravandi Tadeusz Robak Alan Saven John F Seymour Tamar Tadmor Martin S Tallman Constantine Tam Enrico Tiacci Xavier Troussard Clive S Zent Thorsten Zenz Pier Luigi Zinzani Brunangelo Falini

Blood 2017 02 30;129(5):553-560. Epub 2016 Nov 30.

Institute of Hematology, Department of Medicine, University and Hospital of Perugia, Perugia, Italy.

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February 2017

The Dual Syk/JAK Inhibitor Cerdulatinib Antagonizes B-cell Receptor and Microenvironmental Signaling in Chronic Lymphocytic Leukemia.

Authors:
Matthew D Blunt Stefan Koehrer Rachel C Dobson Marta Larrayoz Sarah Wilmore Alice Hayman Jack Parnell Lindsay D Smith Andrew Davies Peter W M Johnson Pamela B Conley Anjali Pandey Jonathan C Strefford Freda K Stevenson Graham Packham Francesco Forconi Greg P Coffey Jan A Burger Andrew J Steele

Clin Cancer Res 2017 May 3;23(9):2313-2324. Epub 2016 Oct 3.

Cancer Sciences Unit (MP824), University of Southampton, Southampton, United Kingdom.

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May 2017

PEITC-mediated inhibition of mRNA translation is associated with both inhibition of mTORC1 and increased eIF2α phosphorylation in established cell lines and primary human leukemia cells.

Authors:
Alison Yeomans Elizabeth Lemm Sarah Wilmore Breeze E Cavell Beatriz Valle-Argos Sergey Krysov Marina Sanchez Hidalgo Elodie Leonard Anne E Willis Francesco Forconi Freda K Stevenson Andrew J Steele Mark J Coldwell Graham Packham

Oncotarget 2016 11;7(46):74807-74819

Cancer Research UK Centre, Faculty of Medicine, University of Southampton, Southampton, UK.

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November 2016

Surface IgM expression and function are associated with clinical behavior, genetic abnormalities, and DNA methylation in CLL.

Authors:
Annalisa D'Avola Samantha Drennan Ian Tracy Isla Henderson Laura Chiecchio Marta Larrayoz Matthew Rose-Zerilli Jonathan Strefford Christoph Plass Peter W Johnson Andrew J Steele Graham Packham Freda K Stevenson Christopher C Oakes Francesco Forconi

Blood 2016 08 14;128(6):816-26. Epub 2016 Jun 14.

Haematology Oncology Group, Cancer Sciences Unit, and Cancer Sciences Unit, Cancer Research UK and National Institute for Health Research (NIHR) Experimental Cancer Medicine Centres, University of Southampton, Southampton, United Kingdom; Haematology Department, University Hospital Southampton NHS Trust, Southampton, United Kingdom.

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August 2016

IL-4 enhances expression and function of surface IgM in CLL cells.

Authors:
Maria M Aguilar-Hernandez Matthew D Blunt Rachel Dobson Alison Yeomans Stephen Thirdborough Marta Larrayoz Lindsay D Smith Adam Linley Jonathan C Strefford Andrew Davies Peter M W Johnson Natalia Savelyeva Mark S Cragg Francesco Forconi Graham Packham Freda K Stevenson Andrew J Steele

Blood 2016 06 21;127(24):3015-25. Epub 2016 Mar 21.

Cancer Research UK Centre, Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom;

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June 2016

The outcome of Chronic lymphocytic leukaemia patients with 97% IGHV gene identity to germline is distinct from cases with <97% identity and similar to those with 98% identity.

Authors:
Zadie Davis Francesco Forconi Anton Parker Anne Gardiner Peter Thomas Daniel Catovsky Matthew Rose-Zerilli Jonathan C Strefford David Oscier

Br J Haematol 2016 Apr 5;173(1):127-36. Epub 2016 Feb 5.

Department of Molecular Pathology, Royal Bournemouth Hospital, Sutton, UK.

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April 2016

Engagement of the B-cell receptor of chronic lymphocytic leukemia cells drives global and MYC-specific mRNA translation.

Authors:
Alison Yeomans Stephen M Thirdborough Beatriz Valle-Argos Adam Linley Sergey Krysov Marina Sanchez Hidalgo Elodie Leonard Muhammad Ishfaq Simon D Wagner Anne E Willis Andrew J Steele Freda K Stevenson Francesco Forconi Mark J Coldwell Graham Packham

Blood 2016 Jan 21;127(4):449-57. Epub 2015 Oct 21.

Cancer Research UK Centre, Faculty of Medicine, University of Southampton, Southampton, United Kingdom; Experimental Cancer Medicine Centre, Faculty of Medicine, University of Southampton, Southampton, United Kingdom;

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January 2016

Molecular prediction of durable remission after first-line fludarabine-cyclophosphamide-rituximab in chronic lymphocytic leukemia.

Authors:
Davide Rossi Lodovico Terzi-di-Bergamo Lorenzo De Paoli Michaela Cerri Guido Ghilardi Annalisa Chiarenza Pietro Bulian Carlo Visco Francesca R Mauro Fortunato Morabito Agostino Cortelezzi Francesco Zaja Francesco Forconi Luca Laurenti Ilaria Del Giudice Massimo Gentile Iolanda Vincelli Marina Motta Marta Coscia Gian Matteo Rigolin Alessandra Tedeschi Antonino Neri Roberto Marasca Omar Perbellini Carol Moreno Giovanni Del Poeta Massimo Massaia Pier Luigi Zinzani Marco Montillo Antonio Cuneo Valter Gattei Robin Foà Gianluca Gaidano

Blood 2015 Oct 14;126(16):1921-4. Epub 2015 Aug 14.

Division of Hematology, Department of Translational Medicine, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy;

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October 2015

Perturbation of the normal immune system in patients with CLL.

Authors:
Francesco Forconi Paul Moss

Blood 2015 Jul 17;126(5):573-81. Epub 2015 Jun 17.

School of Cancer Sciences, University of Birmingham & University Medical School, Birmingham, United Kingdom.

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July 2015

The PI3K/mTOR inhibitor PF-04691502 induces apoptosis and inhibits microenvironmental signaling in CLL and the Eµ-TCL1 mouse model.

Authors:
Matthew D Blunt Matthew J Carter Marta Larrayoz Lindsay D Smith Maria Aguilar-Hernandez Kerry L Cox Thomas Tipton Mark Reynolds Sarah Murphy Elizabeth Lemm Samantha Dias Andrew Duncombe Jonathan C Strefford Peter W M Johnson Francesco Forconi Freda K Stevenson Graham Packham Mark S Cragg Andrew J Steele

Blood 2015 Jun 8;125(26):4032-41. Epub 2015 May 8.

Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom;

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June 2015

Three years of ibrutinib in CLL.

Authors:
Francesco Forconi

Blood 2015 Apr;125(16):2455-6

UNIVERSITY OF SOUTHAMPTON HOSPITAL TRUST.

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April 2015

Genetics and Prognostication in Splenic Marginal Zone Lymphoma: Revelations from Deep Sequencing.

Authors:
Marina Parry Matthew Jj Rose-Zerilli Viktor Ljungström Jane Gibson Jun Wang Renata Walewska Helen Parker Anton Parker Zadie Davis Anne Gardiner Neil McIver-Brown Christina Kalpadakis Aliki Xochelli Achilles Anagnostopoulos Claudia Fazi David Gonzalez de Castro Claire Dearden Guy Pratt Richard Rosenquist Margaret Ashton-Key Francesco Forconi Andrew Collins Paolo Ghia Estella Matutes Gerassimos Pangalis Kostas Stamatopoulos David Oscier Jonathan C Strefford

Clin Cancer Res 2015 Sep 16;21(18):4174-4183. Epub 2015 Mar 16.

Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.

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September 2015

Higher levels of reactive oxygen species are associated with anergy in chronic lymphocytic leukemia.

Authors:
Adam Linley Beatriz Valle-Argos Andrew J Steele Freda K Stevenson Francesco Forconi Graham Packham

Haematologica 2015 Jul 6;100(7):e265-8. Epub 2015 Mar 6.

Cancer Research UK Centre, Cancer Sciences Unit, University of Southampton Faculty of Medicine, Southampton General Hospital, University Hospital Southampton, UK.

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July 2015

DNA methylation profiling identifies two splenic marginal zone lymphoma subgroups with different clinical and genetic features.

Authors:
Alberto J Arribas Andrea Rinaldi Afua A Mensah Ivo Kwee Luciano Cascione Eloy F Robles Jose A Martinez-Climent David Oscier Luca Arcaini Luca Baldini Roberto Marasca Catherine Thieblemont Josette Briere Francesco Forconi Alberto Zamò Massimiliano Bonifacio Manuela Mollejo Fabio Facchetti Stephan Dirnhofer Maurilio Ponzoni Govind Bhagat Miguel A Piris Gianluca Gaidano Emanuele Zucca Davide Rossi Francesco Bertoni

Blood 2015 Mar 22;125(12):1922-31. Epub 2015 Jan 22.

Lymphoma & Genomics Research Program, Institute of Oncology Research, Bellinzona, Switzerland; Oncology Institute of Southern Switzerland, Bellinzona, Switzerland;

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March 2015

Tumor evolutionary directed graphs and the history of chronic lymphocytic leukemia.

Authors:
Jiguang Wang Hossein Khiabanian Davide Rossi Giulia Fabbri Valter Gattei Francesco Forconi Luca Laurenti Roberto Marasca Giovanni Del Poeta Robin Foà Laura Pasqualucci Gianluca Gaidano Raul Rabadan

Elife 2014 Dec 11;3. Epub 2014 Dec 11.

Department of Biomedical Informatics, Columbia University, New York, United States.

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December 2014

Stimulation of surface IgM of chronic lymphocytic leukemia cells induces an unfolded protein response dependent on BTK and SYK.

Authors:
Sergey Krysov Andrew J Steele Vania Coelho Adam Linley Marina Sanchez Hidalgo Matthew Carter Kathleen N Potter Benjamin Kennedy Andrew S Duncombe Margaret Ashton-Key Francesco Forconi Freda K Stevenson Graham Packham

Blood 2014 Nov 28;124(20):3101-9. Epub 2014 Aug 28.

Cancer Research United Kingdom Centre, Cancer Sciences Unit, University of Southampton Faculty of Medicine, Southampton General Hospital, Southampton, United Kingdom;

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November 2014

The meaning and relevance of B-cell receptor structure and function in chronic lymphocytic leukemia.

Authors:
Freda K Stevenson Francesco Forconi Graham Packham

Semin Hematol 2014 Jul 15;51(3):158-67. Epub 2014 May 15.

Cancer Sciences Unit, Cancer Research UK Centre, Faculty of Medicine, University of Southampton, Southampton, Hampshire, United Kingdom.

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July 2014

The outcome of B-cell receptor signaling in chronic lymphocytic leukemia: proliferation or anergy.

Authors:
Graham Packham Serge Krysov Alex Allen Natalia Savelyeva Andrew J Steele Francesco Forconi Freda K Stevenson

Haematologica 2014 Jul;99(7):1138-48

Cancer Research UK Centre, Faculty of Medicine, University of Southampton, UK

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July 2014

Endothelin-1 promotes survival and chemoresistance in chronic lymphocytic leukemia B cells through ETA receptor.

Authors:
Rossana Maffei Jenny Bulgarelli Stefania Fiorcari Silvia Martinelli Ilaria Castelli Vanessa Valenti Davide Rossi Goretta Bonacorsi Patrizia Zucchini Leonardo Potenza Daniele Vallisa Valter Gattei Giovanni Del Poeta Francesco Forconi Gianluca Gaidano Franco Narni Mario Luppi Roberto Marasca

PLoS One 2014 5;9(6):e98818. Epub 2014 Jun 5.

Hematology Division, Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena, Italy.

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August 2015

Variant B cell receptor isotype functions differ in hairy cell leukemia with mutated BRAF and IGHV genes.

Authors:
Nicola J Weston-Bell Francesco Forconi Hanneke C Kluin-Nelemans Surinder S Sahota

PLoS One 2014 30;9(1):e86556. Epub 2014 Jan 30.

Tumour Immunogenetics Group, Cancer Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.

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December 2014

HLA-G is a component of the chronic lymphocytic leukemia escape repertoire to generate immune suppression: impact of the HLA-G 14 base pair (rs66554220) polymorphism.

Authors:
Roberta Rizzo Valentina Audrito Paola Vacca Davide Rossi Davide Brusa Marina Stignani Daria Bortolotti Giovanni D'Arena Marta Coscia Luca Laurenti Francesco Forconi Gianluca Gaidano Maria Cristina Mingari Lorenzo Moretta Fabio Malavasi Silvia Deaglio

Haematologica 2014 May 20;99(5):888-96. Epub 2013 Dec 20.

or

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May 2014

Endothelium-mediated survival of leukemic cells and angiogenesis-related factors are affected by lenalidomide treatment in chronic lymphocytic leukemia.

Authors:
Rossana Maffei Stefania Fiorcari Jenny Bulgarelli Lara Rizzotto Silvia Martinelli Gian Matteo Rigolin Giulia Debbia Ilaria Castelli Goretta Bonacorsi Rita Santachiara Francesco Forconi Davide Rossi Luca Laurenti Giuseppe A Palumbo Daniele Vallisa Antonio Cuneo Gianluca Gaidano Mario Luppi Roberto Marasca

Exp Hematol 2014 Feb 6;42(2):126-36.e1. Epub 2013 Nov 6.

Division of Hematology, Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena, Italy.

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February 2014

Two main genetic pathways lead to the transformation of chronic lymphocytic leukemia to Richter syndrome.

Authors:
Ekaterina Chigrinova Andrea Rinaldi Ivo Kwee Davide Rossi Paola M V Rancoita Jonathan C Strefford David Oscier Kostas Stamatopoulos Theodora Papadaki Francoise Berger Ken H Young Fiona Murray Richard Rosenquist Timothy C Greiner Wing C Chan Ester M Orlandi Marco Lucioni Roberto Marasca Giorgio Inghirami Marco Ladetto Francesco Forconi Sergio Cogliatti Hana Votavova Steven H Swerdlow Stephan Stilgenbauer Miguel A Piris Andras Matolcsy Dominic Spagnolo Eugene Nikitin Alberto Zamò Valter Gattei Govind Bhagat German Ott Emanuele Zucca Gianluca Gaidano Francesco Bertoni

Blood 2013 Oct 4;122(15):2673-82. Epub 2013 Sep 4.

Lymphoma and Genomics Research Program, IOR Institute of Oncology Research, Bellinzona, Switzerland;

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October 2013

Promoter methylation patterns in Richter syndrome affect stem-cell maintenance and cell cycle regulation and differ from de novo diffuse large B-cell lymphoma.

Authors:
Andrea Rinaldi Afua Adjeiwaa Mensah Ivo Kwee Francesco Forconi Ester M Orlandi Marco Lucioni Valter Gattei Roberto Marasca Françoise Berger Sergio Cogliatti Franco Cavalli Emanuele Zucca Gianluca Gaidano Davide Rossi Francesco Bertoni

Br J Haematol 2013 Oct 21;163(2):194-204. Epub 2013 Aug 21.

Lymphoma and Genomics Research Programme, IOR Institute of Oncology Research, Bellinzona, Switzerland.

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October 2013

Identification in CLL of circulating intraclonal subgroups with varying B-cell receptor expression and function.

Authors:
Vânia Coelho Sergey Krysov Andrew Steele Marina Sanchez Hidalgo Peter W Johnson Prabhjoat S Chana Graham Packham Freda K Stevenson Francesco Forconi

Blood 2013 Oct 16;122(15):2664-72. Epub 2013 Aug 16.

Haematology Oncology Group.

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October 2013

Genome-wide high resolution DNA profiling of hairy cell leukaemia.

Authors:
Andrea Rinaldi Ivo Kwee Ken H Young Emanuele Zucca Gianluca Gaidano Francesco Forconi Francesco Bertoni

Br J Haematol 2013 Aug 21;162(4):566-9. Epub 2013 May 21.

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August 2013

Association between molecular lesions and specific B-cell receptor subsets in chronic lymphocytic leukemia.

Authors:
Davide Rossi Valeria Spina Riccardo Bomben Silvia Rasi Michele Dal-Bo Alessio Bruscaggin Francesca Maria Rossi Sara Monti Massimo Degan Carmela Ciardullo Roberto Serra Antonella Zucchetto Josep Nomdedeu Pietro Bulian Alberto Grossi Francesco Zaja Gabriele Pozzato Luca Laurenti Dimitar G Efremov Francesco Di-Raimondo Roberto Marasca Francesco Forconi Giovanni Del Poeta Gianluca Gaidano Valter Gattei

Blood 2013 Jun 1;121(24):4902-5. Epub 2013 May 1.

Division of Hematology, Department of Translational Medicine, Amedeo Avogadro University of Eastern Piedmont, Via Solaroli 17, Novara, Italy.

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June 2013

Integrated mutational and cytogenetic analysis identifies new prognostic subgroups in chronic lymphocytic leukemia.

Authors:
Davide Rossi Silvia Rasi Valeria Spina Alessio Bruscaggin Sara Monti Carmela Ciardullo Clara Deambrogi Hossein Khiabanian Roberto Serra Francesco Bertoni Francesco Forconi Luca Laurenti Roberto Marasca Michele Dal-Bo Francesca Maria Rossi Pietro Bulian Josep Nomdedeu Giovanni Del Poeta Valter Gattei Laura Pasqualucci Raul Rabadan Robin Foà Riccardo Dalla-Favera Gianluca Gaidano

Blood 2013 Feb 13;121(8):1403-12. Epub 2012 Dec 13.

Division of Hematology, Department of Translational Medicine, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy.

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February 2013

MGA, a suppressor of MYC, is recurrently inactivated in high risk chronic lymphocytic leukemia.

Authors:
Lorenzo De Paoli Michaela Cerri Sara Monti Silvia Rasi Valeria Spina Alessio Bruscaggin Mariangela Greco Carmela Ciardullo Rosella Famà Stefania Cresta Rossana Maffei Marco Ladetto Maurizio Martini Luca Laurenti Francesco Forconi Roberto Marasca Luigi M Larocca Francesco Bertoni Gianluca Gaidano Davide Rossi

Leuk Lymphoma 2013 May 12;54(5):1087-90. Epub 2012 Nov 12.

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May 2013

S1P1 expression is controlled by the pro-oxidant activity of p66Shc and is impaired in B-CLL patients with unfavorable prognosis.

Authors:
Nagaja Capitani Laura Patrussi Livio Trentin Orso Maria Lucherini Enrica Cannizzaro Enrica Migliaccio Federica Frezzato Cristina Gattazzo Francesco Forconi Piergiuseppe Pelicci Gianpietro Semenzato Cosima T Baldari

Blood 2012 Nov 1;120(22):4391-9. Epub 2012 Oct 1.

Department of Evolutionary Biology, University of Siena, Siena, Italy.

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November 2012

Clinical heterogeneity of de novo 11q deletion chronic lymphocytic leukaemia: prognostic relevance of extent of 11q deleted nuclei inside leukemic clone.

Authors:
Roberto Marasca Rossana Maffei Silvia Martinelli Stefania Fiorcari Jenny Bulgarelli Giulia Debbia Davide Rossi Francesca Maria Rossi Gian Matteo Rigolin Sara Martinelli Valter Gattei Giovanni Del Poeta Luca Laurenti Francesco Forconi Marco Montillo Gianluca Gaidano Mario Luppi

Hematol Oncol 2013 Jun 2;31(2):88-95. Epub 2012 Oct 2.

Division of Hematology, Dipartimento di Scienze Mediche e Chirurgiche Materno-infantili e dell'Adulto, University of Modena and Reggio Emilia, Modena, Italy.

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June 2013

Different impact of NOTCH1 and SF3B1 mutations on the risk of chronic lymphocytic leukemia transformation to Richter syndrome.

Authors:
Davide Rossi Silvia Rasi Valeria Spina Marco Fangazio Sara Monti Mariangela Greco Carmela Ciardullo Rosella Famà Stefania Cresta Alessio Bruscaggin Luca Laurenti Maurizio Martini Pellegrino Musto Francesco Forconi Roberto Marasca Luigi M Larocca Robin Foà Gianluca Gaidano

Br J Haematol 2012 Aug 10;158(3):426-9. Epub 2012 May 10.

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August 2012

Disruption of BIRC3 associates with fludarabine chemorefractoriness in TP53 wild-type chronic lymphocytic leukemia.

Authors:
Davide Rossi Marco Fangazio Silvia Rasi Tiziana Vaisitti Sara Monti Stefania Cresta Sabina Chiaretti Ilaria Del Giudice Giulia Fabbri Alessio Bruscaggin Valeria Spina Clara Deambrogi Marilisa Marinelli Rosella Famà Mariangela Greco Giulia Daniele Francesco Forconi Valter Gattei Francesco Bertoni Silvia Deaglio Laura Pasqualucci Anna Guarini Riccardo Dalla-Favera Robin Foà Gianluca Gaidano

Blood 2012 Mar 3;119(12):2854-62. Epub 2012 Feb 3.

Division of Hematology, Department of Translational Medicine, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy.

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March 2012

IGHV gene mutational status and 17p deletion are independent molecular predictors in a comprehensive clinical-biological prognostic model for overall survival prediction in chronic lymphocytic leukemia.

Authors:
Pietro Bulian Davide Rossi Francesco Forconi Giovanni Del Poeta Francesco Bertoni Emanuele Zucca Marco Montillo Gabriele Pozzato Giovanni D'Arena Dimitar G Efremov Roberto Marasca Francesco Lauria Gianluca Gaidano Valter Gattei Luca Laurenti

J Transl Med 2012 Jan 30;10:18. Epub 2012 Jan 30.

Clinical and Experimental Onco-Hematology Unit, IRCCS Centro di Riferimento Oncologico, via Franco Gallini 2, 33170 Aviano (PN), Italy.

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January 2012

The IGHV1-69/IGHJ3 recombinations of unmutated CLL are distinct from those of normal B cells.

Authors:
Francesco Forconi Kathleen N Potter Elisa Sozzi Isla Henderson Emanuele Cencini Davide Rossi Riccardo Bomben Valter Gattei Gianluca Gaidano Graham Packham Freda K Stevenson

Blood 2012 Mar 10;119(9):2106-9. Epub 2012 Jan 10.

Hematology, Department of Clinical Medicine and Immunological Sciences, University of Siena and Department of Oncology, Azienda Ospedaliera Universitaria Senese, Siena, Italy.

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March 2012

Multiple myeloma shows no intra-disease clustering of immunoglobulin heavy chain genes.

Authors:
Simone Ferrero Daniela Capello Mirija Svaldi Michela Boi Daniela Gatti Daniela Drandi Davide Rossi Sara Barbiero Barbara Mantoan Elisabetta Mantella Manuela Zanni Paola Ghione Alessandra Larocca Roberto Passera Francesco Bertoni Valter Gattei Francesco Forconi Luca Laurenti Giovanni Del Poeta Roberto Marasca Sergio Cortelazzo Gianluca Gaidano Antonio Palumbo Mario Boccadoro Marco Ladetto

Haematologica 2012 Jun 29;97(6):849-53. Epub 2011 Dec 29.

Division of Hematology, Department of Experimental Medicine and Oncology, University of Turin, Italy.

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June 2012

Integrated DNA copy number and methylation profiling of lymphoid neoplasms using a single array.

Authors:
Ivo Kwee Andrea Rinaldi Paola Rancoita Davide Rossi Daniela Capello Francesco Forconi Nicola Giuliani Roberto Piva Giorgio Inghirami Gianluca Gaidano Emanuele Zucca Francesco Bertoni

Br J Haematol 2012 Feb 25;156(3):354-7. Epub 2011 Nov 25.

Institute of Oncology Research (IOR) and Oncology Institute of Southern Switzerland.

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February 2012

Mutations of NOTCH1 are an independent predictor of survival in chronic lymphocytic leukemia.

Authors:
Davide Rossi Silvia Rasi Giulia Fabbri Valeria Spina Marco Fangazio Francesco Forconi Roberto Marasca Luca Laurenti Alessio Bruscaggin Michaela Cerri Sara Monti Stefania Cresta Rosella Famà Lorenzo De Paoli Pietro Bulian Valter Gattei Anna Guarini Silvia Deaglio Daniela Capello Raul Rabadan Laura Pasqualucci Riccardo Dalla-Favera Robin Foà Gianluca Gaidano

Blood 2012 Jan 10;119(2):521-9. Epub 2011 Nov 10.

Division of Hematology, Department of Clinical and Experimental Medicine, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy.

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January 2012

Mutations of the SF3B1 splicing factor in chronic lymphocytic leukemia: association with progression and fludarabine-refractoriness.

Authors:
Davide Rossi Alessio Bruscaggin Valeria Spina Silvia Rasi Hossein Khiabanian Monica Messina Marco Fangazio Tiziana Vaisitti Sara Monti Sabina Chiaretti Anna Guarini Ilaria Del Giudice Michaela Cerri Stefania Cresta Clara Deambrogi Ernesto Gargiulo Valter Gattei Francesco Forconi Francesco Bertoni Silvia Deaglio Raul Rabadan Laura Pasqualucci Robin Foà Riccardo Dalla-Favera Gianluca Gaidano

Blood 2011 Dec 28;118(26):6904-8. Epub 2011 Oct 28.

Division of Hematology, Department of Clinical and Experimental Medicine, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy.

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December 2011

Simple genetic diagnosis of hairy cell leukemia by sensitive detection of the BRAF-V600E mutation.

Authors:
Enrico Tiacci Gianluca Schiavoni Francesco Forconi Alessia Santi Livio Trentin Achille Ambrosetti Debora Cecchini Elisa Sozzi Paola Francia di Celle Cristiana Di Bello Alessandro Pulsoni Robin Foà Giorgio Inghirami Brunangelo Falini

Blood 2012 Jan 25;119(1):192-5. Epub 2011 Oct 25.

Institute of Hematology, University of Perugia, Perugia, Italy.

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January 2012

The coexistence of chronic lymphocytic leukemia and myeloproliperative neoplasms: a retrospective multicentric GIMEMA experience.

Authors:
Luca Laurenti Michela Tarnani Ilaria Nichele Stefania Ciolli Agostino Cortelezzi Francesco Forconi Davide Rossi Francesca Romana Mauro Giovanni D'Arena Giovanni Del Poeta Marco Montanaro Fortunato Morabito Caterina Musolino Vincenzo Callea Lorenzo Falchi Alessandra Tedeschi Achille Ambrosetti Gianluca Gaidano Giuseppe Leone Robin Foà

Am J Hematol 2011 Dec 22;86(12):1007-12. Epub 2011 Sep 22.

Hematology Institute, Catholic University, Largo A. Gemelli 8, Rome, Italy.

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December 2011

Molecular history of Richter syndrome: origin from a cell already present at the time of chronic lymphocytic leukemia diagnosis.

Authors:
Davide Rossi Valeria Spina Francesco Forconi Daniela Capello Marco Fangazio Silvia Rasi Maurizio Martini Valter Gattei Antonio Ramponi Luigi M Larocca Francesco Bertoni Gianluca Gaidano

Int J Cancer 2012 Jun 25;130(12):3006-10. Epub 2011 Aug 25.

Division of Hematology, Department of Clinical and Experimental Medicine, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy.

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June 2012

Genome-wide DNA profiling better defines the prognosis of chronic lymphocytic leukaemia.

Authors:
Andrea Rinaldi Michael Mian Ivo Kwee Davide Rossi Clara Deambrogi Afua A Mensah Francesco Forconi Valeria Spina Emanuele Cencini Daniela Drandi Marco Ladetto Rita Santachiara Roberto Marasca Valter Gattei Franco Cavalli Emanuele Zucca Gianluca Gaidano Francesco Bertoni

Br J Haematol 2011 Sep 12;154(5):590-9. Epub 2011 Jul 12.

Oncology Institute of Southern Switzerland (IOSI), Bellinzona, Switzerland Division of Haematology, Azienda Ospedaliera S. Maurizio, Bolzano/Bozen, Italy.

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September 2011

Hairy cell leukaemia: biological and clinical overview from immunogenetic insights.

Authors:
Francesco Forconi

Hematol Oncol 2011 Jun 2;29(2):55-66. Epub 2010 Nov 2.

Ematologia e Trapianti, Università di Siena & AOUS, Siena, Italy.

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June 2011

Del(13q14.3) length matters: an integrated analysis of genomic, fluorescence in situ hybridization and clinical data in 169 chronic lymphocytic leukaemia patients with 13q deletion alone or a normal karyotype.

Authors:
Michael Mian Andrea Rinaldi Afua Adjeiwaa Mensah Davide Rossi Marco Ladetto Francesco Forconi Roberto Marasca Valter Gattei Emanuele Zucca Franco Cavalli Gianluca Gaidano Ivo Kwee Francesco Bertoni

Hematol Oncol 2012 Mar 13;30(1):46-9. Epub 2011 Jun 13.

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March 2012

Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation.

Authors:
Giulia Fabbri Silvia Rasi Davide Rossi Vladimir Trifonov Hossein Khiabanian Jing Ma Adina Grunn Marco Fangazio Daniela Capello Sara Monti Stefania Cresta Ernesto Gargiulo Francesco Forconi Anna Guarini Luca Arcaini Marco Paulli Luca Laurenti Luigi M Larocca Roberto Marasca Valter Gattei David Oscier Francesco Bertoni Charles G Mullighan Robin Foá Laura Pasqualucci Raul Rabadan Riccardo Dalla-Favera Gianluca Gaidano

J Exp Med 2011 Jul 13;208(7):1389-401. Epub 2011 Jun 13.

Institute for Cancer Genetics and the Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032, USA.

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July 2011

BRAF mutations in hairy-cell leukemia.

Authors:
Enrico Tiacci Vladimir Trifonov Gianluca Schiavoni Antony Holmes Wolfgang Kern Maria Paola Martelli Alessandra Pucciarini Barbara Bigerna Roberta Pacini Victoria A Wells Paolo Sportoletti Valentina Pettirossi Roberta Mannucci Oliver Elliott Arcangelo Liso Achille Ambrosetti Alessandro Pulsoni Francesco Forconi Livio Trentin Gianpietro Semenzato Giorgio Inghirami Monia Capponi Francesco Di Raimondo Caterina Patti Luca Arcaini Pellegrino Musto Stefano Pileri Claudia Haferlach Susanne Schnittger Giovanni Pizzolo Robin Foà Laurent Farinelli Torsten Haferlach Laura Pasqualucci Raul Rabadan Brunangelo Falini

N Engl J Med 2011 Jun 11;364(24):2305-15. Epub 2011 Jun 11.

Institute of Hematology, University of Perugia, Perugia, Italy.

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June 2011

13q14 deletion size and number of deleted cells both influence prognosis in chronic lymphocytic leukemia.

Authors:
Michele Dal Bo Francesca Maria Rossi Davide Rossi Clara Deambrogi Francesco Bertoni Ilaria Del Giudice Giuseppe Palumbo Mauro Nanni Andrea Rinaldi Ivo Kwee Erika Tissino Giorgia Corradini Alessandro Gozzetti Emanuele Cencini Marco Ladetto Angela Maria Coletta Fabrizio Luciano Pietro Bulian Gabriele Pozzato Luca Laurenti Francesco Forconi Francesco Di Raimondo Roberto Marasca Giovanni Del Poeta Gianluca Gaidano Robin Foà Anna Guarini Valter Gattei

Genes Chromosomes Cancer 2011 Aug 11;50(8):633-43. Epub 2011 May 11.

Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico, IRCCS, Aviano (PN), Italy.

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August 2011

A pilot monocentric analysis of efficacy and safety of Fludarabine-Campath combination (Flucam) as first line treatment in elderly patients with chronic lymphocytic leukaemia and Tp53 disfunction.

Authors:
Emanuele Cencini Elisa Sozzi Anna Sicuranza Alberto Fabbri Donatella Raspadori Francesco Lauria Francesco Forconi

Br J Haematol 2011 Jul 26;154(2):271-4. Epub 2011 Apr 26.

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July 2011

Insight into the behavior of hairy cell leukemia by immunogenetic analysis.

Authors:
Francesco Forconi Emanuele Cencini Elisa Sozzi Anna Sicuranza Donatella Raspadori Francesco Lauria

Leuk Lymphoma 2011 Jun 19;52 Suppl 2:103-7. Epub 2011 Apr 19.

Sezione di Ematologia e Trapianti, Dipartimento di Medicina Clinica e Scienze Immunologiche, Università di Siena & AOUS, Siena, Italy.

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June 2011

Rituximab with pentostatin or cladribine: an effective combination treatment for hairy cell leukemia after disease recurrence.

Authors:
Monica Else Claire E Dearden Estella Matutes Francesco Forconi Francesco Lauria Humayun Ahmad Susan Kelly Anandika Liyanage Vijitha Ratnayake Jagadeesan Shankari Ioana Whalley Daniel Catovsky

Leuk Lymphoma 2011 Jun 19;52 Suppl 2:75-8. Epub 2011 Apr 19.

The Institute of Cancer Research and the Royal Marsden NHS Trust, Sutton, UK.

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June 2011

Alternative methods of cladribine administration.

Authors:
Francesco Lauria Emanuele Cencini Francesco Forconi

Leuk Lymphoma 2011 Jun 19;52 Suppl 2:34-7. Epub 2011 Apr 19.

Sezione di Ematologia e Trapianti, Dipartimento di Medicina Clinica e Scienze Immunologiche, Università di Siena & AOUS, Siena, Italy.

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June 2011

B-cell receptor, clinical course and prognosis in chronic lymphocytic leukaemia: the growing saga of the IGHV3 subgroup gene usage.

Authors:
Michele Dal-Bo Ilaria Del Giudice Riccardo Bomben Daniela Capello Francesco Bertoni Francesco Forconi Luca Laurenti Davide Rossi Antonella Zucchetto Gabriele Pozzato Roberto Marasca Dimitar G Efremov Anna Guarini Giovanni Del Poeta Robin Foà Gianluca Gaidano Valter Gattei

Br J Haematol 2011 Apr 8;153(1):3-14. Epub 2011 Feb 8.

Department of Cellular Biotechnologies and Haematology, Sapienza University, Rome, Italy.

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April 2011

The genetics of Richter syndrome reveals disease heterogeneity and predicts survival after transformation.

Authors:
Davide Rossi Valeria Spina Clara Deambrogi Silvia Rasi Luca Laurenti Kostas Stamatopoulos Luca Arcaini Marco Lucioni Gabrielle B Rocque Zijun Y Xu-Monette Carlo Visco Julie Chang Ekaterina Chigrinova Francesco Forconi Roberto Marasca Caroline Besson Theodora Papadaki Marco Paulli Luigi M Larocca Stefano A Pileri Valter Gattei Francesco Bertoni Robin Foà Ken H Young Gianluca Gaidano

Blood 2011 Mar 25;117(12):3391-401. Epub 2011 Jan 25.

Division of Hematology, Department of Clinical and Experimental Medicine, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy.

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March 2011

The host genetic background of DNA repair mechanisms is an independent predictor of survival in diffuse large B-cell lymphoma.

Authors:
Davide Rossi Silvia Rasi Alice Di Rocco Alberto Fabbri Francesco Forconi Annunziata Gloghini Alessio Bruscaggin Silvia Franceschetti Marco Fangazio Lorenzo De Paoli Riccardo Bruna Daniela Capello Annalisa Chiappella Chiara Lobetti Bodoni Manuela Giachelia Maria Chiara Tisi Enrico M Pogliani Francesco Lauria Marco Ladetto Stefan Hohaus Maurizio Martelli Umberto Vitolo Antonino Carbone Robin Foà Gianluca Gaidano

Blood 2011 Feb 14;117(8):2405-13. Epub 2010 Dec 14.

Division of Hematology, Department of Clinical and Experimental Medicine & CRIFF, Amedeo Avogadro University of Eastern Piedmont, Via Solaroli 17, Novara, Italy.

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February 2011

Molecular insight into the biology and clinical course of hairy cell leukemia utilizing immunoglobulin gene analysis.

Authors:
Francesco Forconi Emanuele Cencini Anna Sicuranza Elisa Sozzi Francesco Lauria

Leuk Lymphoma 2011 Jan 6;52(1):15-23. Epub 2010 Dec 6.

Ematologia e Trapianti, Università di Siena, Siena, Italy.

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January 2011

A variant of the LRP4 gene affects the risk of chronic lymphocytic leukaemia transformation to Richter syndrome.

Authors:
Silvia Rasi Valeria Spina Alessio Bruscaggin Tiziana Vaisitti Claudio Tripodo Francesco Forconi Lorenzo De Paoli Marco Fangazio Elisa Sozzi Emanuele Cencini Luca Laurenti Roberto Marasca Carlo Visco Zijun Y Xu-Monette Valter Gattei Ken H Young Fabio Malavasi Silvia Deaglio Gianluca Gaidano Davide Rossi

Br J Haematol 2011 Feb 1;152(3):284-94. Epub 2010 Dec 1.

Division of Haematology, Department of Clinical and Experimental Medicine & IRCAD, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy.

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February 2011

Genome-wide DNA profiling of marginal zone lymphomas identifies subtype-specific lesions with an impact on the clinical outcome.

Authors:
Andrea Rinaldi Michael Mian Ekaterina Chigrinova Luca Arcaini Govind Bhagat Urban Novak Paola M V Rancoita Cassio P De Campos Francesco Forconi Randy D Gascoyne Fabio Facchetti Maurilio Ponzoni Silvia Govi Andrés J M Ferreri Manuela Mollejo Miguel A Piris Luca Baldini Jean Soulier Catherine Thieblemont Vincenzo Canzonieri Valter Gattei Roberto Marasca Silvia Franceschetti Gianluca Gaidano Alessandra Tucci Silvia Uccella Maria Grazia Tibiletti Stephan Dirnhofer Claudio Tripodo Claudio Doglioni Riccardo Dalla Favera Franco Cavalli Emanuele Zucca Ivo Kwee Francesco Bertoni

Blood 2011 Feb 29;117(5):1595-604. Epub 2010 Nov 29.

Laboratory of Experimental Oncology and Lymphoma Unit, Oncology Institute of Southern Switzerland, via Vincenzo Vela 6, Bellinzona, Switzerland.

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February 2011

Immunogenetics features and genomic lesions in splenic marginal zone lymphoma.

Authors:
Andrea Rinaldi Francesco Forconi Luca Arcaini Michael Mian Elena Sozzi Silvia Zibellini Luca Baldini Silvia Franceschetti Gianluca Gaidano Roberto Marasca Manuela Mollejo Miguel A Piris Alessandra Tucci Fabio Facchetti Govind Bhagat Riccardo D Favera Paola M V Rancoita Emanuele Zucca Ivo Kwee Francesco Bertoni

Br J Haematol 2010 Dec;151(5):435-9

Laboratory of Experimental Oncology and Lymphoma Unit, Oncology Institute of Southern Switzerland (IOSI), Bellinzona, Switzerland.

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December 2010

Predicting the clinical course of Hodgkin lymphoma.

Authors:
Alberto Fabbri Alessandro Gozzetti Francesco Forconi Francesco Lauria

Nat Rev Clin Oncol 2010 Aug;7(8):doi:10.1038/nrclinonc.2010.36-c1

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August 2010

Multicentre validation of a prognostic index for overall survival in chronic lymphocytic leukaemia.

Authors:
Pietro Bulian Michela Tarnani Davide Rossi Francesco Forconi Giovanni Del Poeta Francesco Bertoni Emanuele Zucca Marco Montillo Gabriele Pozzato Silvia Deaglio Giovanni D'Arena Dimitar Efremov Roberto Marasca Francesco Lauria Valter Gattei Gianluca Gaidano Luca Laurenti

Hematol Oncol 2011 Jun 28;29(2):91-9. Epub 2010 Jul 28.

Clinical and Experimental Onco-Hematology Unit, IRCCS, Centro di Riferimento Oncologico, Aviano (PN), Italy.

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June 2011

Lack of allelic exclusion by secondary rearrangements of tumour B-cell receptor light chains in hairy cell leukaemia.

Authors:
Elisa Sozzi Teresa Amato Surinder S Sahota Sandra Nuti Donatella Raspadori Anna Sicuranza Emanuele Cencini Piero Tosi Francesco Lauria Francesco Forconi

Hematol Oncol 2011 Mar;29(1):31-7

Sezione and Unità di Ematologia, Università di Siena & AOUS, Italy.

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March 2011

Stereotyped patterns of B-cell receptor in splenic marginal zone lymphoma.

Authors:
Silvia Zibellini Daniela Capello Francesco Forconi Paolo Marcatili Davide Rossi Sara Rattotti Silvia Franceschetti Elisa Sozzi Emanuele Cencini Roberto Marasca Luca Baldini Alessandra Tucci Francesco Bertoni Francesco Passamonti Ester Orlandi Marzia Varettoni Michele Merli Silvia Rizzi Valter Gattei Anna Tramontano Marco Paulli Gianluca Gaidano Luca Arcaini

Haematologica 2010 Oct 29;95(10):1792-6. Epub 2010 May 29.

Division of Hematology, Department of Oncohematology, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Viale Golgi 19, Pavia, Italy.

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October 2010

MDM4 (MDMX) is overexpressed in chronic lymphocytic leukaemia (CLL) and marks a subset of p53wild-type CLL with a poor cytotoxic response to Nutlin-3.

Authors:
Michele Dal Bo Paola Secchiero Massimo Degan Daniela Marconi Riccardo Bomben Gabriele Pozzato Gianluca Gaidano Giovanni Del Poeta Francesco Forconi Giorgio Zauli Valter Gattei

Br J Haematol 2010 Jul 28;150(2):237-9. Epub 2010 Apr 28.

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July 2010

Angiopoietin-2 plasma dosage predicts time to first treatment and overall survival in chronic lymphocytic leukemia.

Authors:
Rossana Maffei Silvia Martinelli Rita Santachiara Davide Rossi Carla Guarnotta Elisa Sozzi Antonella Zucchetto Gian Matteo Rigolin Stefania Fiorcari Ilaria Castelli Marcella Fontana Valeria Coluccio Giovanna Leonardi Patrizia Zucchini Claudio Tripodo Antonio Cuneo Valter Gattei Giovanni Del Poeta Francesco Forconi Gianluca Gaidano Giuseppe Torelli Roberto Marasca

Blood 2010 Jul 9;116(4):584-92. Epub 2010 Apr 9.

Hematology Unit, Department of Oncology and Hematology, University of Modena and Reggio Emilia, Via Del Pozzo 71, Modena, Italy.

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July 2010

Molecular and clinical features of chronic lymphocytic leukemia with stereotyped B-cell receptors in a Ukrainian cohort.

Authors:
Nadiia Bilous Riccardo Bomben Michele Dal Bo Daniela Capello Francesco Forconi Luca Laurenti Francesco Bertoni Dimitar G Efremov Roberto Marasca Giovanni Del Poeta Zoya Martina Iryna Kryachouk Iryna Dyagil Gianluca Gaidano Anatoliy Chumak Valter Gattei Iryna Abramenko

Leuk Lymphoma 2010 May;51(5):822-38

Research Center for Radiation Medicine, Academy of Medical Sciences, Kiev, 04053, Ukraine.

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May 2010

Impact of the host genetic background on prognosis of chronic lymphocytic leukemia.

Authors:
Silvia Rasi Francesco Forconi Alessio Bruscaggin Elisa Sozzi Gianluca Gaidano Davide Rossi

Blood 2010 Feb;115(5):1106-7

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February 2010

Expression of mutated IGHV3-23 genes in chronic lymphocytic leukemia identifies a disease subset with peculiar clinical and biological features.

Authors:
Riccardo Bomben Michele Dal-Bo Dania Benedetti Daniela Capello Francesco Forconi Daniela Marconi Francesco Bertoni Rossana Maffei Luca Laurenti Davide Rossi Maria Ilaria Del Principe Fabrizio Luciano Elisa Sozzi Ilaria Cattarossi Antonella Zucchetto Francesca Maria Rossi Pietro Bulian Emanuele Zucca Milena S Nicoloso Massimo Degan Roberto Marasca Dimitar G Efremov Giovanni Del Poeta Gianluca Gaidano Valter Gattei

Clin Cancer Res 2010 Jan 12;16(2):620-8. Epub 2010 Jan 12.

Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico, I.R.C.C.S., Aviano (PN), Italy.

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January 2010

IGHD3-3 fails to behave as unfavourable prognostic marker in chronic lymphocytic leukaemia.

Authors:
Riccardo Bomben Michele Dal Bo Daniela Capello Francesco Forconi Francesco Bertoni Rossana Maffei Luca Laurenti Davide Rossi Emanuele Zucca Massimo Degan Roberto Marasca Dimitar G Efremov Giovanni Del Poeta Gianluca Gaidano Valter Gattei

Br J Haematol 2010 Apr 7;149(2):299-302. Epub 2009 Jan 7.

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April 2010

Impaired expression of p66Shc, a novel regulator of B-cell survival, in chronic lymphocytic leukemia.

Authors:
Nagaja Capitani Orso Maria Lucherini Elisa Sozzi Micol Ferro Nico Giommoni Francesca Finetti Giulia De Falco Emanuele Cencini Donatella Raspadori Pier Giuseppe Pelicci Francesco Lauria Francesco Forconi Cosima T Baldari

Blood 2010 May 8;115(18):3726-36. Epub 2010 Jan 8.

Department of Evolutionary Biology, University of Siena, 53100 Siena, Italy.

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May 2010

Genomic profiling of Richter's syndrome: recurrent lesions and differences with de novo diffuse large B-cell lymphomas.

Authors:
Marta Scandurra Davide Rossi Clara Deambrogi Paola M V Rancoita Ekaterina Chigrinova Michael Mian Michaela Cerri Silvia Rasi Elisa Sozzi Francesco Forconi Maurilio Ponzoni Santiago M Moreno Miguel A Piris Giorgio Inghirami Emanuele Zucca Valter Gattei Andrea Rinaldi Ivo Kwee Gianluca Gaidano Francesco Bertoni

Hematol Oncol 2010 Jun;28(2):62-7

Laboratory of Experimental Oncology, Oncology Institute of Southern Switzerland (IOSI), Bellinzona, Switzerland.

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June 2010

The normal IGHV1-69-derived B-cell repertoire contains stereotypic patterns characteristic of unmutated CLL.

Authors:
Francesco Forconi Kathleen N Potter Isla Wheatley Nikos Darzentas Elisa Sozzi Kostas Stamatopoulos C Ian Mockridge Graham Packham Freda K Stevenson

Blood 2010 Jan 3;115(1):71-7. Epub 2009 Nov 3.

Hematology and Bone Marrow Transplantation, University of Siena and AOUS, Siena, Italy.

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January 2010

Combination therapies to improve the long-term outcome in hairy cell leukemia.

Authors:
Francesco Lauria Francesco Forconi

Leuk Lymphoma 2009 Oct;50 Suppl 1:18-22

Department of Hematology and Transplant, University of Siena, AOUS, Siena, Italy.

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October 2009

Intrinsic and extrinsic factors influencing the clinical course of B-cell chronic lymphocytic leukemia: prognostic markers with pathogenetic relevance.

Authors:
Michele Dal-Bo Francesco Bertoni Francesco Forconi Antonella Zucchetto Riccardo Bomben Roberto Marasca Silvia Deaglio Luca Laurenti Dimitar G Efremov Gianluca Gaidano Giovanni Del Poeta Valter Gattei

J Transl Med 2009 Aug 28;7:76. Epub 2009 Aug 28.

Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico, IRCCS, Aviano (PN), Italy.

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August 2009

Hairy cell leukemias with unmutated IGHV genes define the minor subset refractory to single-agent cladribine and with more aggressive behavior.

Authors:
Francesco Forconi Elisa Sozzi Emanuele Cencini Francesco Zaja Tamara Intermesoli Caterina Stelitano Luigi Rigacci Filippo Gherlinzoni Renato Cantaffa Anna Baraldi Andrea Gallamini Alfonso Zaccaria Alessandro Pulsoni Marco Gobbi Maristella Tassi Donatella Raspadori Lorenzo Leoncini Andrea Rinaldi Elena Sabattini Francesco Bertoni Stefano A Pileri Francesco Lauria

Blood 2009 Nov 10;114(21):4696-702. Epub 2009 Aug 10.

Ematologia e Trapianti, Università di Siena, Azienda Ospedaliera Universitaria Senese, Siena, Italy.

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November 2009

Stereotyped B-cell receptor is an independent risk factor of chronic lymphocytic leukemia transformation to Richter syndrome.

Authors:
Davide Rossi Valeria Spina Michaela Cerri Silvia Rasi Clara Deambrogi Lorenzo De Paoli Luca Laurenti Rossana Maffei Francesco Forconi Francesco Bertoni Emanuele Zucca Claudio Agostinelli Antonello Cabras Marco Lucioni Maurizio Martini Michele Magni Silvia Deaglio Marco Ladetto Josep F Nomdedeu Caroline Besson Antonio Ramponi Vincenzo Canzonieri Marco Paulli Roberto Marasca Luigi M Larocca Antonino Carbone Stefano A Pileri Valter Gattei Gianluca Gaidano

Clin Cancer Res 2009 Jul 9;15(13):4415-22. Epub 2009 Jun 9.

Amedeo Avogadro University of Eastern Piedmont, Novara, Italy.

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July 2009

The prognosis of clinical monoclonal B cell lymphocytosis differs from prognosis of Rai 0 chronic lymphocytic leukaemia and is recapitulated by biological risk factors.

Authors:
Davide Rossi Elisa Sozzi Alessia Puma Lorenzo De Paoli Silvia Rasi Valeria Spina Alessandro Gozzetti Maristella Tassi Emanuele Cencini Donatella Raspadori Valeria Pinto Francesco Bertoni Valter Gattei Francesco Lauria Gianluca Gaidano Francesco Forconi

Br J Haematol 2009 Jun 5;146(1):64-75. Epub 2009 May 5.

Division of Haematology, Department of Clinical and Experimental Medicine and BRMA, Amedeo Avogadro University of Eastern Piedmont and Azienda Ospedaliero-Universitaria Maggiore della Carità, Novara, Italy.

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June 2009