Francesco Di Virgilio

Francesco Di Virgilio

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Francesco Di Virgilio

Francesco Di Virgilio

Publications by authors named "Francesco Di Virgilio"

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Pharmacological blockade of the P2X7 receptor reverses retinal damage in a rat model of type 1 diabetes.

Authors:
Carmen Clapp Nundehui Diaz-Lezama Elva Adan-Castro Gabriela Ramirez-Hernandez Bibiana Moreno-Carranza Alba Clara Sarti Simonetta Falzoni Anna Solini Francesco Di Virgilio

Acta Diabetol 2019 Sep 13;56(9):1031-1036. Epub 2019 Apr 13.

Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Via Borsari 46, 44121, Ferrara, Italy.

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http://dx.doi.org/10.1007/s00592-019-01343-4DOI Listing
September 2019

TRPP2 dysfunction decreases ATP-evoked calcium, induces cell aggregation and stimulates proliferation in T lymphocytes.

Authors:
Riccardo Magistroni Alessandra Mangolini Sonia Guzzo Francesca Testa Mario R Rapanà Renzo Mignani Giorgia Russo Francesco di Virgilio Gianluca Aguiari

BMC Nephrol 2019 Sep 13;20(1):355. Epub 2019 Sep 13.

Department of Biomedical and Surgical Specialty Sciences, University of Ferrara, via Luigi Borsari 46, 44100, Ferrara, Italy.

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http://dx.doi.org/10.1186/s12882-019-1540-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743124PMC
September 2019

Role of the P2X7 receptor in tumor-associated inflammation.

Authors:
Elena Adinolfi Elena De Marchi Elisa Orioli Anna Pegoraro Francesco Di Virgilio

Curr Opin Pharmacol 2019 Aug 25;47:59-64. Epub 2019 Mar 25.

Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Italy.

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http://dx.doi.org/10.1016/j.coph.2019.02.012DOI Listing
August 2019

Editorial overview: Purinergic P2X receptors in innate immunity and inflammation.

Authors:
Francesco Di Virgilio Pablo Pelegrín

Curr Opin Pharmacol 2019 Aug 12;47:141-144. Epub 2019 Jun 12.

Biomedical Research Institute of Murcia IMIB-Arrixaca, University Clinical Hospital Virgen de la Arrixaca, Murcia, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.coph.2019.05.003DOI Listing
August 2019

Role of the P2X7 receptor in and glioma tumor growth.

Authors:
Letícia Scussel Bergamin Marina Capece Erica Salaro Alba Clara Sarti Simonetta Falzoni Mery Stéfani Leivas Pereira Marco Antônio De Bastiani Juliete Nathali Scholl Ana Maria O Battastini Francesco Di Virgilio

Oncotarget 2019 Aug 6;10(47):4840-4856. Epub 2019 Aug 6.

Department of Morphology, Surgery and Experimental Medicine, Section of Pathology, Oncology and Experimental Biology, University of Ferrara, Ferrara, Italy.

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http://dx.doi.org/10.18632/oncotarget.27106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690673PMC
August 2019

The P2X7 Receptor Is Overexpressed in the Lesional Skin of Subjects Affected by Hidradenitis Suppurativa: A Preliminary Study.

Authors:
Marco Manfredini Anna Lisa Giuliani Giulia Ruina Roberta Gafà Cristina Bosi Elisabetta Zoppas Francesco Di Virgilio Vincenzo Bettoli

Dermatology 2019 Aug 27:1-8. Epub 2019 Aug 27.

Section of Dermatology, Department of Clinical and Experimental Medicine, University of Ferrara, Ferrara, Italy.

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http://dx.doi.org/10.1159/000502026DOI Listing
August 2019

Extreme thrombocytosis in systemic juvenile idiopathic arthritis. A case report.

Authors:
Alessandra Iacono Monica Sprocati Anna Lisa Giuliani Francesco Di Virgilio Caterina Borgna-Pignatti Giuseppe Maggiore

Ital J Pediatr 2019 Jun 24;45(1):73. Epub 2019 Jun 24.

Department of Medical Sciences, Pediatrics, University of Ferrara, Ferrara, Italy.

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https://ijponline.biomedcentral.com/articles/10.1186/s13052-
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http://dx.doi.org/10.1186/s13052-019-0664-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591931PMC
June 2019

The P2X7 receptor modulates immune cells infiltration, ectonucleotidases expression and extracellular ATP levels in the tumor microenvironment.

Authors:
Elena De Marchi Elisa Orioli Anna Pegoraro Sabina Sangaletti Paola Portararo Antonio Curti Mario Paolo Colombo Francesco Di Virgilio Elena Adinolfi

Oncogene 2019 05 17;38(19):3636-3650. Epub 2019 Jan 17.

Department of Morphology, Surgery and Experimental Medicine, Section of Pathology, Oncology and Experimental Biology, University of Ferrara, Via Luigi Borsari, 46, 44121, Ferrara, Italy.

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http://dx.doi.org/10.1038/s41388-019-0684-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756114PMC
May 2019

Intercellular Calcium Signaling Induced by ATP Potentiates Macrophage Phagocytosis.

Authors:
Sara Zumerle Bianca Calì Fabio Munari Roberta Angioni Francesco Di Virgilio Barbara Molon Antonella Viola

Cell Rep 2019 Apr;27(1):1-10.e4

Department of Biomedical Sciences, University of Padova, Padova, Italy; Fondazione Istituto di Ricerca Pediatrica Città della Speranza, Padova, Italy.

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http://dx.doi.org/10.1016/j.celrep.2019.03.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449513PMC
April 2019

Amyloid β-dependent mitochondrial toxicity in mouse microglia requires P2X7 receptor expression and is prevented by nimodipine.

Authors:
Paola Chiozzi Alba Clara Sarti Juana M Sanz Anna Lisa Giuliani Elena Adinolfi Valentina Vultaggio-Poma Simonetta Falzoni Francesco Di Virgilio

Sci Rep 2019 Apr 24;9(1):6475. Epub 2019 Apr 24.

Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy.

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http://dx.doi.org/10.1038/s41598-019-42931-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6482182PMC
April 2019

The P2X7 Receptor Is Shed Into Circulation: Correlation With C-Reactive Protein Levels.

Authors:
Anna Lisa Giuliani Merhej Berchan Juana M Sanz Angelina Passaro Stefano Pizzicotti Valentina Vultaggio-Poma Alba Clara Sarti Francesco Di Virgilio

Front Immunol 2019 12;10:793. Epub 2019 Apr 12.

Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy.

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00793
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http://dx.doi.org/10.3389/fimmu.2019.00793DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474289PMC
April 2019

P2X7 Receptor Expression in Patients With Serositis Related to Systemic Lupus Erythematosus.

Authors:
Federica Furini Anna Lisa Giuliani Mattia Erminio Parlati Marcello Govoni Francesco Di Virgilio Alessandra Bortoluzzi

Front Pharmacol 2019 29;10:435. Epub 2019 Apr 29.

Section of Rheumatology, Department of Medical Sciences, University of Ferrara and Azienda Ospedaliero-Universitaria Sant'Anna di Ferrara, Cona, Italy.

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http://dx.doi.org/10.3389/fphar.2019.00435DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6501575PMC
April 2019

Extracellular nucleotides and nucleosides as signalling molecules.

Authors:
Anna Lisa Giuliani Alba Clara Sarti Francesco Di Virgilio

Immunol Lett 2019 01 12;205:16-24. Epub 2018 Nov 12.

Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferarra, Italy. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01652478183035
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http://dx.doi.org/10.1016/j.imlet.2018.11.006DOI Listing
January 2019

Extracellular ATP and P2 purinergic signalling in the tumour microenvironment.

Authors:
Francesco Di Virgilio Alba Clara Sarti Simonetta Falzoni Elena De Marchi Elena Adinolfi

Nat Rev Cancer 2018 10;18(10):601-618

Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy.

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http://dx.doi.org/10.1038/s41568-018-0037-0DOI Listing
October 2018

Islet-Derived eATP Fuels Autoreactive CD8 T Cells and Facilitates the Onset of Type 1 Diabetes.

Authors:
Sara Tezza Moufida Ben Nasr Francesca D'Addio Andrea Vergani Vera Usuelli Simonetta Falzoni Roberto Bassi Sergio Dellepiane Carmen Fotino Chiara Rossi Anna Maestroni Anna Solini Domenico Corradi Elisa Giani Chiara Mameli Federico Bertuzzi Marcus G Pezzolesi Clive H Wasserfall Mark A Atkinson Ernst-Martin Füchtbauer Camillo Ricordi Franco Folli Francesco Di Virgilio Antonello Pileggi Sirano Dhe-Paganon Gian Vincenzo Zuccotti Paolo Fiorina

Diabetes 2018 10 31;67(10):2038-2053. Epub 2018 Jul 31.

Division of Nephrology, Boston Children's Hospital, Harvard Medical School, Boston, MA

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http://dx.doi.org/10.2337/db17-1227DOI Listing
October 2018

Microglia P2X4 receptors as pharmacological targets for demyelinating diseases.

Authors:
Francesco Di Virgilio Alba Clara Sarti

EMBO Mol Med 2018 08;10(8)

Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy.

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http://dx.doi.org/10.15252/emmm.201809369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6079532PMC
August 2018

Extracellular ATP is a danger signal activating P2X7 receptor in a LPS mediated inflammation (ARDS/ALI).

Authors:
Sanja Cicko Thomas Christian Köhler Cemil Korcan Ayata Tobias Müller Nicolas Ehrat Anja Meyer Madelon Hossfeld Andreas Zech Francesco Di Virgilio Marco Idzko

Oncotarget 2018 Jul 17;9(55):30635-30648. Epub 2018 Jul 17.

University Hospital Freiburg, Department of Pneumology, Freiburg, Germany.

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http://dx.doi.org/10.18632/oncotarget.25761DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078145PMC
July 2018

Modulation of innate and adaptive immunity by P2X ion channels.

Authors:
Francesco Di Virgilio Alba Clara Sarti Fabio Grassi

Curr Opin Immunol 2018 06 7;52:51-59. Epub 2018 Apr 7.

Institute for Research in Biomedicine, Università della Svizzera Italiana, Via Vincenzo Vela 6, CH-6500 Bellinzona, Switzerland; Department of Medical Biotechnology and Translational Medicine (BIOMETRA), Università degli Studi di Milano, Via G.B. Viotti 3/5, 20133 Milan, Italy; Istituto Nazionale Genetica Molecolare "Romeo ed Enrica Invernizzi", Via Francesco Sforza, 35-20122 Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.coi.2018.03.026DOI Listing
June 2018

Macrophage P2X4 receptors augment bacterial killing and protect against sepsis.

Authors:
Balázs Csóka Zoltán H Németh Ildikó Szabó Daryl L Davies Zoltán V Varga János Pálóczi Simonetta Falzoni Francesco Di Virgilio Rieko Muramatsu Toshihide Yamashita Pál Pacher György Haskó

JCI Insight 2018 06 7;3(11). Epub 2018 Jun 7.

Department of Anesthesiology, Columbia University, New York, New York, USA.

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http://dx.doi.org/10.1172/jci.insight.99431DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997389PMC
June 2018

The P2X7 receptor: A main player in inflammation.

Authors:
Elena Adinolfi Anna Lisa Giuliani Elena De Marchi Anna Pegoraro Elisa Orioli Francesco Di Virgilio

Biochem Pharmacol 2018 05 27;151:234-244. Epub 2017 Dec 27.

Department of Morphology, Surgery and Experimental Medicine, Section of Pathology, Oncology and Experimental Biology, University of Ferrara, Ferrara, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2017.12.021DOI Listing
May 2018

The Elusive P2X7 Macropore.

Authors:
Francesco Di Virgilio Günther Schmalzing Fritz Markwardt

Trends Cell Biol 2018 05 10;28(5):392-404. Epub 2018 Feb 10.

Institute for Physiology, Martin Luther University, Halle/Saale, Germany.

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http://dx.doi.org/10.1016/j.tcb.2018.01.005DOI Listing
May 2018

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Authors:
Lorenzo Galluzzi Ilio Vitale Stuart A Aaronson John M Abrams Dieter Adam Patrizia Agostinis Emad S Alnemri Lucia Altucci Ivano Amelio David W Andrews Margherita Annicchiarico-Petruzzelli Alexey V Antonov Eli Arama Eric H Baehrecke Nickolai A Barlev Nicolas G Bazan Francesca Bernassola Mathieu J M Bertrand Katiuscia Bianchi Mikhail V Blagosklonny Klas Blomgren Christoph Borner Patricia Boya Catherine Brenner Michelangelo Campanella Eleonora Candi Didac Carmona-Gutierrez Francesco Cecconi Francis K-M Chan Navdeep S Chandel Emily H Cheng Jerry E Chipuk John A Cidlowski Aaron Ciechanover Gerald M Cohen Marcus Conrad Juan R Cubillos-Ruiz Peter E Czabotar Vincenzo D'Angiolella Ted M Dawson Valina L Dawson Vincenzo De Laurenzi Ruggero De Maria Klaus-Michael Debatin Ralph J DeBerardinis Mohanish Deshmukh Nicola Di Daniele Francesco Di Virgilio Vishva M Dixit Scott J Dixon Colin S Duckett Brian D Dynlacht Wafik S El-Deiry John W Elrod Gian Maria Fimia Simone Fulda Ana J García-Sáez Abhishek D Garg Carmen Garrido Evripidis Gavathiotis Pierre Golstein Eyal Gottlieb Douglas R Green Lloyd A Greene Hinrich Gronemeyer Atan Gross Gyorgy Hajnoczky J Marie Hardwick Isaac S Harris Michael O Hengartner Claudio Hetz Hidenori Ichijo Marja Jäättelä Bertrand Joseph Philipp J Jost Philippe P Juin William J Kaiser Michael Karin Thomas Kaufmann Oliver Kepp Adi Kimchi Richard N Kitsis Daniel J Klionsky Richard A Knight Sharad Kumar Sam W Lee John J Lemasters Beth Levine Andreas Linkermann Stuart A Lipton Richard A Lockshin Carlos López-Otín Scott W Lowe Tom Luedde Enrico Lugli Marion MacFarlane Frank Madeo Michal Malewicz Walter Malorni Gwenola Manic Jean-Christophe Marine Seamus J Martin Jean-Claude Martinou Jan Paul Medema Patrick Mehlen Pascal Meier Sonia Melino Edward A Miao Jeffery D Molkentin Ute M Moll Cristina Muñoz-Pinedo Shigekazu Nagata Gabriel Nuñez Andrew Oberst Moshe Oren Michael Overholtzer Michele Pagano Theocharis Panaretakis Manolis Pasparakis Josef M Penninger David M Pereira Shazib Pervaiz Marcus E Peter Mauro Piacentini Paolo Pinton Jochen H M Prehn Hamsa Puthalakath Gabriel A Rabinovich Markus Rehm Rosario Rizzuto Cecilia M P Rodrigues David C Rubinsztein Thomas Rudel Kevin M Ryan Emre Sayan Luca Scorrano Feng Shao Yufang Shi John Silke Hans-Uwe Simon Antonella Sistigu Brent R Stockwell Andreas Strasser Gyorgy Szabadkai Stephen W G Tait Daolin Tang Nektarios Tavernarakis Andrew Thorburn Yoshihide Tsujimoto Boris Turk Tom Vanden Berghe Peter Vandenabeele Matthew G Vander Heiden Andreas Villunger Herbert W Virgin Karen H Vousden Domagoj Vucic Erwin F Wagner Henning Walczak David Wallach Ying Wang James A Wells Will Wood Junying Yuan Zahra Zakeri Boris Zhivotovsky Laurence Zitvogel Gerry Melino Guido Kroemer

Cell Death Differ 2018 03 23;25(3):486-541. Epub 2018 Jan 23.

Paris Descartes/Paris V University, Paris, France.

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http://dx.doi.org/10.1038/s41418-017-0012-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864239PMC
March 2018

Non-nucleotide Agonists Triggering P2X7 Receptor Activation and Pore Formation.

Authors:
Francesco Di Virgilio Anna L Giuliani Valentina Vultaggio-Poma Simonetta Falzoni Alba C Sarti

Front Pharmacol 2018 1;9:39. Epub 2018 Feb 1.

Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy.

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http://dx.doi.org/10.3389/fphar.2018.00039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5799242PMC
February 2018

Assessing Extracellular ATP as Danger Signal In Vivo: The pmeLuc System.

Authors:
Francesco Di Virgilio Paolo Pinton Simonetta Falzoni

Methods Mol Biol 2016 ;1417:115-29

Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Via Borsari, 46, 44121, Ferrara, Italy.

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http://dx.doi.org/10.1007/978-1-4939-3566-6_7DOI Listing
December 2017

Design, synthesis and evaluation in an LPS rodent model of neuroinflammation of a novel F-labelled PET tracer targeting P2X7.

Authors:
Enrico Raffaele Fantoni Diego Dal Ben Simonetta Falzoni Francesco Di Virgilio Simon Lovestone Antony Gee

EJNMMI Res 2017 Dec 4;7(1):31. Epub 2017 Apr 4.

Department of Imaging Sciences and Biomedical Engineering, King's College London, St Thomas' Hospital, 4th floor Lambeth Wing, SE1 7EH, London, UK.

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http://ejnmmires.springeropen.com/articles/10.1186/s13550-01
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http://dx.doi.org/10.1186/s13550-017-0275-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378566PMC
December 2017

Extracellular ATP Activates the NLRP3 Inflammasome and Is an Early Danger Signal of Skin Allograft Rejection.

Authors:
Joaquín Amores-Iniesta Maria Barberà-Cremades Carlos M Martínez José A Pons Beatriz Revilla-Nuin Laura Martínez-Alarcón Francesco Di Virgilio Pascual Parrilla Alberto Baroja-Mazo Pablo Pelegrín

Cell Rep 2017 Dec;21(12):3414-3426

Experimental Surgery Group, Biomedical Research Institute of Murcia (IMIB-Arrixaca), University Clinical Hospital Virgen de la Arrixaca, 30120 Murcia, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.11.079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746605PMC
December 2017

ATP Release from Chemotherapy-Treated Dying Leukemia Cells Elicits an Immune Suppressive Effect by Increasing Regulatory T Cells and Tolerogenic Dendritic Cells.

Authors:
Mariangela Lecciso Darina Ocadlikova Sabina Sangaletti Sara Trabanelli Elena De Marchi Elisa Orioli Anna Pegoraro Paola Portararo Camilla Jandus Andrea Bontadini Annarita Redavid Valentina Salvestrini Pedro Romero Mario P Colombo Francesco Di Virgilio Michele Cavo Elena Adinolfi Antonio Curti

Front Immunol 2017 22;8:1918. Epub 2017 Dec 22.

Department of Experimental, Diagnostic and Specialty Medicine, Institute of Hematology L. and A. Seràgnoli, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.

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http://dx.doi.org/10.3389/fimmu.2017.01918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5744438PMC
December 2017

Use of luciferase probes to measure ATP in living cells and animals.

Authors:
Giampaolo Morciano Alba Clara Sarti Saverio Marchi Sonia Missiroli Simonetta Falzoni Lizzia Raffaghello Vito Pistoia Carlotta Giorgi Francesco Di Virgilio Paolo Pinton

Nat Protoc 2017 Aug 6;12(8):1542-1562. Epub 2017 Jul 6.

Section of Pathology, Oncology and Experimental Biology, Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy.

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http://dx.doi.org/10.1038/nprot.2017.052DOI Listing
August 2017

P2Y Receptor Activation Promotes Inflammation and Tissue Remodeling in Pulmonary Fibrosis.

Authors:
Tobias Müller Susanne Fay Rodolfo Paula Vieira Harry Karmouty-Quintana Sanja Cicko Cemil Korcan Ayata Gernot Zissel Torsten Goldmann Giuseppe Lungarella Davide Ferrari Francesco Di Virgilio Bernard Robaye Jean-Marie Boeynaems Eduardo R Lazarowski Michael R Blackburn Marco Idzko

Front Immunol 2017 22;8:1028. Epub 2017 Aug 22.

Department of Pneumology, University Medical Center Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.3389/fimmu.2017.01028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5572280PMC
August 2017

The P2X7 Receptor in Infection and Inflammation.

Authors:
Francesco Di Virgilio Diego Dal Ben Alba Clara Sarti Anna Lisa Giuliani Simonetta Falzoni

Immunity 2017 07;47(1):15-31

Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy.

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http://dx.doi.org/10.1016/j.immuni.2017.06.020DOI Listing
July 2017

The purinergic receptor subtype P2Y2 mediates chemotaxis of neutrophils and fibroblasts in fibrotic lung disease.

Authors:
Tobias Müller Susanne Fay Rodolfo Paula Vieira Harry Karmouty-Quintana Sanja Cicko Korcan Ayata Gernot Zissel Torsten Goldmann Giuseppe Lungarella Davide Ferrari Francesco Di Virgilio Bernard Robaye Jean-Marie Boeynaems Michael R Blackburn Marco Idzko

Oncotarget 2017 May;8(22):35962-35972

University Hospital Freiburg, Department of Pneumology, Germany.

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http://dx.doi.org/10.18632/oncotarget.16414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482630PMC
May 2017

The P2X7 Receptor-Interleukin-1 Liaison.

Authors:
Anna Lisa Giuliani Alba C Sarti Simonetta Falzoni Francesco Di Virgilio

Front Pharmacol 2017 16;8:123. Epub 2017 Mar 16.

Department of Morphology, Surgery and Experimental Medicine, University of Ferrara Ferrara, Italy.

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http://dx.doi.org/10.3389/fphar.2017.00123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5353276PMC
March 2017

Extracellular ATP induces apoptosis through P2X7R activation in acute myeloid leukemia cells but not in normal hematopoietic stem cells.

Authors:
Valentina Salvestrini Stefania Orecchioni Giovanna Talarico Francesca Reggiani Cristina Mazzetti Francesco Bertolini Elisa Orioli Elena Adinolfi Francesco Di Virgilio Annalisa Pezzi Michele Cavo Roberto M Lemoli Antonio Curti

Oncotarget 2017 Jan;8(4):5895-5908

Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.

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http://www.oncotarget.com/fulltext/13927
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http://dx.doi.org/10.18632/oncotarget.13927DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351599PMC
January 2017

"Hemophagocytic Lymphohistiocytosis after EBV reactivation and ibrutinib treatment in relapsed/refractory Chronic Lymphocytic Leukemia".

Authors:
Maurizio Cavallari Maria Ciccone Simonetta Falzoni Francesco Cavazzini Luca Formigaro Francesco Di Virgilio Antonella Rotola Gian Matteo Rigolin Antonio Cuneo

Leuk Res Rep 2017 22;7:11-13. Epub 2017 Jan 22.

Hematology Section, Azienda Ospedaliero-Universitaria Arcispedale S. Anna, Ferrara, Italy.

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http://dx.doi.org/10.1016/j.lrr.2017.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288319PMC
January 2017

Purinergic signalling in autoimmunity: A role for the P2X7R in systemic lupus erythematosus?

Authors:
Francesco Di Virgilio Anna Lisa Giuliani

Biomed J 2016 Oct 27;39(5):326-338. Epub 2016 Oct 27.

Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy.

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http://dx.doi.org/10.1016/j.bj.2016.08.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138817PMC
October 2016

P2 receptors in cancer progression and metastatic spreading.

Authors:
Francesco Di Virgilio Simonetta Falzoni Anna Lisa Giuliani Elena Adinolfi

Curr Opin Pharmacol 2016 08 24;29:17-25. Epub 2016 May 24.

Department of Morphology, Surgery and Experimental Medicine, Section of Pathology, Oncology and Experimental Biology, University of Ferrara, Italy.

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http://dx.doi.org/10.1016/j.coph.2016.05.001DOI Listing
August 2016

P2X7 targeting inhibits growth of human mesothelioma.

Authors:
Francesca Amoroso Erica Salaro Simonetta Falzoni Paola Chiozzi Anna Lisa Giuliani Giorgio Cavallesco Pio Maniscalco Andrea Puozzo Ilaria Bononi Fernanda Martini Mauro Tognon Francesco Di Virgilio

Oncotarget 2016 Aug;7(31):49664-49676

Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy.

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http://dx.doi.org/10.18632/oncotarget.10430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5226537PMC
August 2016

Editorial overview: Cancer.

Authors:
Francesco Di Virgilio Paolo Pinton

Curr Opin Pharmacol 2016 08 29;29:v-vii. Epub 2016 Jul 29.

Department of Morphology, Surgery and Experimental Medicine, Section of Pathology, Oncology and Experimental Biology, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, 44121 Ferrara, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.coph.2016.07.009DOI Listing
August 2016

Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance.

Authors:
Federico Pietrocola Jonathan Pol Erika Vacchelli Shuan Rao David P Enot Elisa E Baracco Sarah Levesque Francesca Castoldi Nicolas Jacquelot Takahiro Yamazaki Laura Senovilla Guillermo Marino Fernando Aranda Sylvère Durand Valentina Sica Alexis Chery Sylvie Lachkar Verena Sigl Norma Bloy Aitziber Buque Simonetta Falzoni Bernhard Ryffel Lionel Apetoh Francesco Di Virgilio Frank Madeo Maria Chiara Maiuri Laurence Zitvogel Beth Levine Josef M Penninger Guido Kroemer

Cancer Cell 2016 07;30(1):147-160

Gustave Roussy Cancer Campus, 94800 Villejuif, France; INSERM, U1138, 75006 Paris, France; Equipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, 75006 Paris, France; Université Paris Descartes/Paris V, Sorbonne Paris Cité, 75006 Paris, France; Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus, 94800 Villejuif, France; Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, 75015 Paris, France; Department of Women's and Children's Health, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden; INSERM U1138, Centre de Recherche des Cordeliers, 75006 Paris, France. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715805PMC
July 2016

Involvement of the P2X7-NLRP3 axis in leukemic cell proliferation and death.

Authors:
Erica Salaro Alessia Rambaldi Simonetta Falzoni Francesca Saveria Amoroso Alessia Franceschini Alba Clara Sarti Massimo Bonora Francesco Cavazzini Gian Matteo Rigolin Maria Ciccone Valentina Audrito Silvia Deaglio Pablo Pelegrin Paolo Pinton Antonio Cuneo Francesco Di Virgilio

Sci Rep 2016 05 25;6:26280. Epub 2016 May 25.

Department of Morphology, Surgery and Experimental Medicine, Section of Pathology, Oncology and Experimental Biology, University of Ferrara, Italy.

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http://dx.doi.org/10.1038/srep26280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879576PMC
May 2016

P2RX7: A receptor with a split personality in inflammation and cancer.

Authors:
Francesco Di Virgilio

Mol Cell Oncol 2016 Mar 3;3(2):e1010937. Epub 2015 Feb 3.

Department of Morphology; Surgery and Experimental Medicine; Section of Pathology; Oncology and Experimental Biology; University of Ferrara ; Ferrara, Italy.

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http://dx.doi.org/10.1080/23723556.2015.1010937DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905332PMC
March 2016

P2X receptors and inflammation.

Authors:
Francesco Di Virgilio

Curr Med Chem 2015 ;22(7):866-77

Department of Morphology, Surgery and Experimental Medicine, Section of Pathology, Oncology and Experimental Biology, Via Borsari 46, University of Ferrara, Ferrara, Italy.

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http://dx.doi.org/10.2174/0929867322666141210155311DOI Listing
October 2015

Purinergic signaling in the immune system.

Authors:
Francesco Di Virgilio Marta Vuerich

Auton Neurosci 2015 Sep 30;191:117-23. Epub 2015 Apr 30.

Department of Morphology, Surgery and Experimental Medicine, Section of Pathology, Oncology and Experimental Biology, University of Ferrara Italy.

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http://dx.doi.org/10.1016/j.autneu.2015.04.011DOI Listing
September 2015

The P2X7 receptor directly interacts with the NLRP3 inflammasome scaffold protein.

Authors:
Alessia Franceschini Marina Capece Paola Chiozzi Simonetta Falzoni Juana Maria Sanz Alba Clara Sarti Massimo Bonora Paolo Pinton Francesco Di Virgilio

FASEB J 2015 Jun 17;29(6):2450-61. Epub 2015 Feb 17.

*Department of Morphology, Surgery and Experimental Medicine, Section of Pathology, Oncology and Experimental Biology, Department of Medical Sciences, Section of Internal Medicine, Gerontology, and Clinical Nutrition, and Laboratory of Technologies for Advanced Therapies, University of Ferrara, Ferrara, Italy

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June 2015

A Commentary on "PTX3 is an Extrinsic Oncosuppressor Regulating Complement-Dependent Inflammation in Cancer".

Authors:
Francesco Di Virgilio

Front Oncol 2015 28;5:118. Epub 2015 May 28.

Section of Pathology, Oncology and Experimental Biology, Department of Morphology, Surgery and Experimental Medicine, University of Ferrara , Ferrara , Italy.

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http://dx.doi.org/10.3389/fonc.2015.00118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446995PMC
June 2015

Trophic activity of human P2X7 receptor isoforms A and B in osteosarcoma.

Authors:
Anna Lisa Giuliani Davide Colognesi Tiziana Ricco Carlotta Roncato Marina Capece Francesca Amoroso Qi Guang Wang Elena De Marchi Allison Gartland Francesco Di Virgilio Elena Adinolfi

PLoS One 2014 16;9(9):e107224. Epub 2014 Sep 16.

Department of Morphology, Surgery and Experimental Medicine, Section of Experimental Pathology, Oncology and Biology, University of Ferrara, Ferrara, Italy.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0107224PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165768PMC
May 2015

Accelerated tumor progression in mice lacking the ATP receptor P2X7.

Authors:
Elena Adinolfi Marina Capece Alessia Franceschini Simonetta Falzoni Anna L Giuliani Alessandra Rotondo Alba C Sarti Massimo Bonora Susanne Syberg Domenica Corigliano Paolo Pinton Niklas R Jorgensen Luigi Abelli Laura Emionite Lizzia Raffaghello Vito Pistoia Francesco Di Virgilio

Cancer Res 2015 Feb 26;75(4):635-44. Epub 2014 Dec 26.

Department of Morphology, Surgery and Experimental Medicine, Section of Pathology, Oncology and Experimental Biology, University of Ferrara, Ferrara, Italy.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-1259DOI Listing
February 2015

p53 at the endoplasmic reticulum regulates apoptosis in a Ca2+-dependent manner.

Authors:
Carlotta Giorgi Massimo Bonora Giovanni Sorrentino Sonia Missiroli Federica Poletti Jan M Suski Fabian Galindo Ramirez Rosario Rizzuto Francesco Di Virgilio Ester Zito Pier Paolo Pandolfi Mariusz R Wieckowski Fabio Mammano Giannino Del Sal Paolo Pinton

Proc Natl Acad Sci U S A 2015 Feb 26;112(6):1779-84. Epub 2015 Jan 26.

Department of Morphology, Surgery and Experimental Medicine, Section of Pathology, Oncology and Experimental Biology, University of Ferrara, Ferrara 44121, Italy;

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http://dx.doi.org/10.1073/pnas.1410723112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330769PMC
February 2015

Possible protective role of the 489C>T P2X7R polymorphism in Alzheimer's disease.

Authors:
Juana M Sanz Simonetta Falzoni Roberta Rizzo Francesco Cipollone Giovanni Zuliani Francesco Di Virgilio

Exp Gerontol 2014 Dec 16;60:117-9. Epub 2014 Oct 16.

Department of Morphology, Surgery and Experimental Medicine, Section of General Pathology, University of Ferrara, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.exger.2014.10.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266448PMC
December 2014

Anti-tumor activity of a miR-199-dependent oncolytic adenovirus.

Authors:
Elisa Callegari Bahaeldin K Elamin Lucilla D'Abundo Simonetta Falzoni Giovanna Donvito Farzaneh Moshiri Maddalena Milazzo Giuseppe Altavilla Luciano Giacomelli Francesca Fornari Akseli Hemminki Francesco Di Virgilio Laura Gramantieri Massimo Negrini Silvia Sabbioni

PLoS One 2013 12;8(9):e73964. Epub 2013 Sep 12.

Dipartimento di Morfologia, Chirurgia e Medicina Sperimentale, Università di Ferrara, Ferrara, Italy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771938PMC
May 2014

Purinergic regulation of airway inflammation.

Authors:
Michael Koeppen Francesco Di Virgilio Eric T Clambey Holger K Eltzschig

Subcell Biochem 2011 ;55:159-93

Department of Anesthesiology, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA,

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http://link.springer.com/10.1007/978-94-007-1217-1_7
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February 2014

Purinergic signalling and cancer.

Authors:
Geoffrey Burnstock Francesco Di Virgilio

Purinergic Signal 2013 Dec;9(4):491-540

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http://link.springer.com/10.1007/s11302-013-9372-5
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3889385PMC
December 2013

The adjuvant MF59 induces ATP release from muscle that potentiates response to vaccination.

Authors:
Maria Vono Marianna Taccone Paola Caccin Marilena Gallotta Giovanna Donvito Simonetta Falzoni Emiliano Palmieri Michele Pallaoro Rino Rappuoli Francesco Di Virgilio Ennio De Gregorio Cesare Montecucco Anja Seubert

Proc Natl Acad Sci U S A 2013 Dec 9;110(52):21095-100. Epub 2013 Dec 9.

Dipartimento di Scienze Biomediche and Istituto di Neuroscienze del Consiglio Nazionale delle Ricerche, Università di Padova, 35131 Padova, Italy.

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http://dx.doi.org/10.1073/pnas.1319784110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876261PMC
December 2013

The therapeutic potential of modifying inflammasomes and NOD-like receptors.

Authors:
Francesco Di Virgilio

Pharmacol Rev 2013 Jul 16;65(3):872-905. Epub 2013 Apr 16.

Department of Morphology, Surgery and Experimental Medicine, Section of General Pathology, University of Ferrara, Via Borsari 46, 44121 Ferrara, Italy.

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http://dx.doi.org/10.1124/pr.112.006171DOI Listing
July 2013

Detecting adenosine triphosphate in the pericellular space.

Authors:
Simonetta Falzoni Giovanna Donvito Francesco Di Virgilio

Interface Focus 2013 Jun;3(3):20120101

Department of Morphology, Surgery and Experimental Medicine, Section of General Pathology , University of Ferrara , Via Borsari 46, Ferrara 44121 , Italy.

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http://dx.doi.org/10.1098/rsfs.2012.0101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638417PMC
June 2013

Why myotoxin-containing snake venoms possess powerful nucleotidases?

Authors:
Paola Caccin Patrizia Pellegatti Julián Fernandez Maria Vono Mariana Cintra-Francischinelli Bruno Lomonte José María Gutiérrez Francesco Di Virgilio Cesare Montecucco

Biochem Biophys Res Commun 2013 Jan 19;430(4):1289-93. Epub 2012 Dec 19.

Dipartimento di Scienze Biomediche, Università di Padova, and Istituto di Neuroscienze-CNR Sezione di Padova, Padova 35121, Italy.

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http://dx.doi.org/10.1016/j.bbrc.2012.11.129DOI Listing
January 2013

Purinergic P2Y₂ receptors promote neutrophil infiltration and hepatocyte death in mice with acute liver injury.

Authors:
Cemil Korcan Ayata Stephanie C Ganal Birgit Hockenjos Karolina Willim Rodolfo P Vieira Melanie Grimm Bernard Robaye Jean Marie Boeynaems Francesco Di Virgilio Patrizia Pellegatti Andreas Diefenbach Marco Idzko Peter Hasselblatt

Gastroenterology 2012 Dec 11;143(6):1620-1629.e4. Epub 2012 Sep 11.

Department of Medicine V, University Hospital Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1053/j.gastro.2012.08.049DOI Listing
December 2012

IL-18 associates to microvesicles shed from human macrophages by a LPS/TLR-4 independent mechanism in response to P2X receptor stimulation.

Authors:
Sara Gulinelli Erica Salaro Marta Vuerich Dania Bozzato Cinzia Pizzirani Giorgio Bolognesi Marco Idzko Francesco Di Virgilio Davide Ferrari

Eur J Immunol 2012 Dec 26;42(12):3334-45. Epub 2012 Oct 26.

Department of Experimental and Diagnostic Medicine, Section of General Pathology, University of Ferrara, Ferrara, Italy.

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http://dx.doi.org/10.1002/eji.201142268DOI Listing
December 2012

P2 receptors and immunity.

Authors:
Amel Rayah Jean M Kanellopoulos Francesco Di Virgilio

Microbes Infect 2012 Nov 13;14(14):1254-62. Epub 2012 Aug 13.

Institut de Biochimie et Biophysique Moléculaire et Cellulaire, CNRS UMR 8619, Université Paris Sud, 91405 Orsay Cedex, France.

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http://dx.doi.org/10.1016/j.micinf.2012.07.006DOI Listing
November 2012

Purines, purinergic receptors, and cancer.

Authors:
Francesco Di Virgilio

Cancer Res 2012 Nov 22;72(21):5441-7. Epub 2012 Oct 22.

Department of Experimental and Diagnostic Medicine, Section of General Pathology, University of Ferrara, Ferrara, Italy.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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November 2012

Special issue on cell and molecular biology of purinergic signalling: an introduction.

Authors:
Geoffrey Burnstock Paul A Insel Francesco Di Virgilio

Purinergic Signal 2012 Sep;8(3):341

Autonomic Neuroscience Centre, Royal Free and University College Medical School, Rowland Hill Street, London, NW3 2PF, UK.

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http://dx.doi.org/10.1007/s11302-012-9312-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3360090PMC
September 2012

AMP affects intracellular Ca2+ signaling, migration, cytokine secretion and T cell priming capacity of dendritic cells.

Authors:
Elisabeth Panther Thorsten Dürk Davide Ferrari Francesco Di Virgilio Melanie Grimm Stephan Sorichter Sanja Cicko Yared Herouy Johannes Norgauer Marco Idzko Tobias Müller

PLoS One 2012 18;7(5):e37560. Epub 2012 May 18.

Department of Gastroenterology, University Medical Centre Freiburg, Freiburg, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356328PMC
September 2012

The sixth sense: hematopoietic stem cells detect danger through purinergic signaling.

Authors:
Lara Rossi Valentina Salvestrini Davide Ferrari Francesco Di Virgilio Roberto M Lemoli

Blood 2012 Sep 11;120(12):2365-75. Epub 2012 Jul 11.

Department of Hematology and Oncological Sciences, L. and A. Seràgnoli, Institute of Hematology, University of Bologna and S. Orsola-Malpighi Hospital, Bologna, Italy.

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http://dx.doi.org/10.1182/blood-2012-04-422378DOI Listing
September 2012

Extracellular ATP exerts opposite effects on activated and regulatory CD4+ T cells via purinergic P2 receptor activation.

Authors:
Sara Trabanelli Darina Ocadlíková Sara Gulinelli Antonio Curti Valentina Salvestrini Rodolfo de Paula Vieira Marco Idzko Francesco Di Virgilio Davide Ferrari Roberto M Lemoli

J Immunol 2012 Aug 2;189(3):1303-10. Epub 2012 Jul 2.

Department of Hematology and Oncological Sciences L. & A. Seràgnoli, University of Bologna, 9-40138 Bologna, Italy.

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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.1103800
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August 2012

P2X7 receptor-stimulation causes fever via PGE2 and IL-1β release.

Authors:
Maria Barberà-Cremades Alberto Baroja-Mazo Ana I Gomez Francisco Machado Francesco Di Virgilio Pablo Pelegrín

FASEB J 2012 Jul 6;26(7):2951-62. Epub 2012 Apr 6.

Inflammation and Experimental Surgery Unit, Centro de Investigación Biomédica en Red de Enfermedades Hepaticas y Digestivas, University Hospital Virgen de Arrixaca-Fundación Formación Investigación Sanitaria Región Murcia, Murcia, Spain.

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http://www.fasebj.org/cgi/doi/10.1096/fj.12-205765
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July 2012

Expression of P2X7 receptor increases in vivo tumor growth.

Authors:
Elena Adinolfi Lizzia Raffaghello Anna Lisa Giuliani Luigi Cavazzini Marina Capece Paola Chiozzi Giovanna Bianchi Guido Kroemer Vito Pistoia Francesco Di Virgilio

Cancer Res 2012 Jun 13;72(12):2957-69. Epub 2012 Apr 13.

Section of General Pathology, Department of Experimental and Diagnostic Medicine, University of Ferrara, Ferrara, Italy.

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http://dx.doi.org/10.1158/0008-5472.CAN-11-1947DOI Listing
June 2012

Transient P2X7 receptor activation triggers macrophage death independent of Toll-like receptors 2 and 4, caspase-1, and pannexin-1 proteins.

Authors:
Peter J Hanley Moritz Kronlage Carsten Kirschning Adriana del Rey Francesco Di Virgilio Jens Leipziger Iain P Chessell Sarah Sargin Mikhail A Filippov Otto Lindemann Simon Mohr Volker Königs Hermann Schillers Martin Bähler Albrecht Schwab

J Biol Chem 2012 Mar 10;287(13):10650-63. Epub 2012 Jan 10.

Institut für Molekulare Zellbiologie, Westfälische Wilhelms-Universität Münster, 48149 Münster, Germany.

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http://dx.doi.org/10.1074/jbc.M111.332676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3323034PMC
March 2012

Purinergic signaling inhibits human acute myeloblastic leukemia cell proliferation, migration, and engraftment in immunodeficient mice.

Authors:
Valentina Salvestrini Roberta Zini Lara Rossi Sara Gulinelli Rossella Manfredini Elisa Bianchi Wanda Piacibello Luisa Caione Giorgia Migliardi Maria Rosaria Ricciardi Agostino Tafuri Marco Romano Simona Salati Francesco Di Virgilio Sergio Ferrari Michele Baccarani Davide Ferrari Roberto M Lemoli

Blood 2012 Jan 3;119(1):217-26. Epub 2011 Nov 3.

Department of Hematology and Oncological Sciences, L. & A. Seràgnoli, University of Bologna and S. Orsola-Malpighi Hospital, Bologna, Italy.

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http://dx.doi.org/10.1182/blood-2011-07-370775DOI Listing
January 2012

Autophagy-dependent anticancer immune responses induced by chemotherapeutic agents in mice.

Authors:
Mickaël Michaud Isabelle Martins Abdul Qader Sukkurwala Sandy Adjemian Yuting Ma Patrizia Pellegatti Shensi Shen Oliver Kepp Marie Scoazec Grégoire Mignot Santiago Rello-Varona Maximilien Tailler Laurie Menger Erika Vacchelli Lorenzo Galluzzi François Ghiringhelli Francesco di Virgilio Laurence Zitvogel Guido Kroemer

Science 2011 Dec;334(6062):1573-7

INSERM, U848, Villejuif, France.

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http://dx.doi.org/10.1126/science.1208347DOI Listing
December 2011

The P2X7 receptor and Pannexin-1 are both required for the promotion of multinucleated macrophages by the inflammatory cytokine GM-CSF.

Authors:
Irma Lemaire Simonetta Falzoni Bin Zhang Patrizia Pellegatti Francesco Di Virgilio

J Immunol 2011 Oct 24;187(7):3878-87. Epub 2011 Aug 24.

Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada.

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http://dx.doi.org/10.4049/jimmunol.1002780DOI Listing
October 2011

European meeting "P2 receptors: new targets for the treatment of osteoporosis".

Authors:
Niklas Rye Jørgensen Jean-Marie Boeynaems Francesco Di Virgilio

Purinergic Signal 2011 Jun 18;7(2):275-6. Epub 2011 Feb 18.

Research Center of Aging and Osteoporosis, Department of Medicine and Department of Clinical Biochemistry, Copenhagen University Hospital Glostrup, Glostrup, Denmark.

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http://dx.doi.org/10.1007/s11302-011-9223-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3146637PMC
June 2011

P2 receptors and extracellular ATP: a novel homeostatic pathway in inflammation.

Authors:
Martijn Jan Leo Bours Pieter Cornelis Dagnelie Anna Lisa Giuliani Anke Wesselius Francesco Di Virgilio

Front Biosci (Schol Ed) 2011 Jun 1;3:1443-56. Epub 2011 Jun 1.

Maastricht University, Department of Epidemiology, School for Public Health and Primary Care (CAPHRI), Maastricht, The Netherlands.

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June 2011

P2X7 receptor drives osteoclast fusion by increasing the extracellular adenosine concentration.

Authors:
Patrizia Pellegatti Simonetta Falzoni Giovanna Donvito Irma Lemaire Francesco Di Virgilio

FASEB J 2011 Apr 13;25(4):1264-74. Epub 2011 Jan 13.

Department of Experimental and Diagnostic Medicine, Section of General Pathology, Interdisciplinary Center for the Study of Inflammation, University of Ferrara, Ferrara, Italy.

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http://dx.doi.org/10.1096/fj.10-169854DOI Listing
April 2011

P2X7 receptor signaling in the pathogenesis of smoke-induced lung inflammation and emphysema.

Authors:
Monica Lucattelli Sanja Cicko Tobias Müller Marek Lommatzsch Giovanna De Cunto Silvia Cardini William Sundas Melanie Grimm Robert Zeiser Thorsten Dürk Gernot Zissel Stephan Sorichter Davide Ferrari Francesco Di Virgilio J Christian Virchow Giuseppe Lungarella Marco Idzko

Am J Respir Cell Mol Biol 2011 Mar 27;44(3):423-9. Epub 2010 May 27.

Department of Pulmonary Medicine, University of Freiburg, Germany.

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http://dx.doi.org/10.1165/rcmb.2010-0038OCDOI Listing
March 2011

Purinergic stimulation of human mesenchymal stem cells potentiates their chemotactic response to CXCL12 and increases the homing capacity and production of proinflammatory cytokines.

Authors:
Davide Ferrari Sara Gulinelli Valentina Salvestrini Giovanna Lucchetti Roberta Zini Rossella Manfredini Luisa Caione Wanda Piacibello Marilena Ciciarello Lara Rossi Marco Idzko Sergio Ferrari Francesco Di Virgilio Roberto M Lemoli

Exp Hematol 2011 Mar 9;39(3):360-74, 374.e1-5. Epub 2010 Dec 9.

Department of Experimental and Diagnostic Medicine, Section of General Pathology, University of Ferrara, via Borsari 46, Ferrara, Italy.

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http://dx.doi.org/10.1016/j.exphem.2010.12.001DOI Listing
March 2011

Graft-versus-host disease is enhanced by extracellular ATP activating P2X7R.

Authors:
Konrad Wilhelm Jayanthi Ganesan Tobias Müller Christoph Dürr Melanie Grimm Andreas Beilhack Christine D Krempl Stephan Sorichter Ulrike V Gerlach Eva Jüttner Alf Zerweck Frank Gärtner Patrizia Pellegatti Francesco Di Virgilio Davide Ferrari Neeraja Kambham Paul Fisch Jürgen Finke Marco Idzko Robert Zeiser

Nat Med 2010 Dec 21;16(12):1434-8. Epub 2010 Nov 21.

Department of Hematology and Oncology, Freiburg University Medical Center, Albert-Ludwigs-University, Freiburg, Germany.

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http://dx.doi.org/10.1038/nm.2242DOI Listing
December 2010

ATP secreted by endothelial cells blocks CX₃CL 1-elicited natural killer cell chemotaxis and cytotoxicity via P2Y₁₁ receptor activation.

Authors:
Stefania Gorini Giulia Callegari Giulia Romagnoli Caterina Mammi Domenico Mavilio Giuseppe Rosano Massimo Fini Francesco Di Virgilio Sara Gulinelli Simonetta Falzoni Andrea Cavani Davide Ferrari Andrea la Sala

Blood 2010 Nov 28;116(22):4492-500. Epub 2010 Jul 28.

Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), San Raffaele Pisana, Rome, Italy.

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http://dx.doi.org/10.1182/blood-2009-12-260828DOI Listing
November 2010

Trophic activity of a naturally occurring truncated isoform of the P2X7 receptor.

Authors:
Elena Adinolfi Maria Cirillo Ronja Woltersdorf Simonetta Falzoni Paola Chiozzi Patrizia Pellegatti Maria Giulia Callegari Doriana Sandonà Fritz Markwardt Günther Schmalzing Francesco Di Virgilio

FASEB J 2010 Sep 7;24(9):3393-404. Epub 2010 May 7.

Department of Experimental and Diagnostic Medicine, Section of General Pathology, Interdisciplinary Center for the Study of Inflammation, University of Ferrara, via L. Borsari 46, 44100, Ferrara, Italy.

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http://dx.doi.org/10.1096/fj.09-153601DOI Listing
September 2010

Dysregulation of P2X7 receptor-inflammasome axis in SAPHO syndrome: successful treatment with anakinra.

Authors:
Matteo Colina Cinzia Pizzirani Micheline Khodeir Simonetta Falzoni Marco Bruschi Francesco Trotta Francesco Di Virgilio

Rheumatology (Oxford) 2010 Jul 18;49(7):1416-8. Epub 2010 Mar 18.

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http://dx.doi.org/10.1093/rheumatology/keq074DOI Listing
July 2010

Diadenosine homodinucleotide products of ADP-ribosyl cyclases behave as modulators of the purinergic receptor P2X7.

Authors:
Santina Bruzzone Giovanna Basile Madhu Parakkottil Chothi Lucilla Nobbio Cesare Usai Emanuela Jacchetti Angelo Schenone Andreas H Guse Francesco Di Virgilio Antonio De Flora Elena Zocchi

J Biol Chem 2010 Jul 3;285(27):21165-74. Epub 2010 May 3.

Department of Experimental Medicine, Section of Biochemistry, and Center of Excellence for Biomedical Research (CEBR), University of Genova, Viale Benedetto XV/1, 16132 Genova, Italy.

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http://dx.doi.org/10.1074/jbc.M109.097964DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898341PMC
July 2010

Purinergic receptor inhibition prevents the development of smoke-induced lung injury and emphysema.

Authors:
Sanja Cicko Monica Lucattelli Tobias Müller Marek Lommatzsch Giovanna De Cunto Silvia Cardini William Sundas Melanine Grimm Robert Zeiser Thorsten Dürk Gernot Zissel Jean-Marie Boeynaems Stephan Sorichter Davide Ferrari Francesco Di Virgilio J Christian Virchow Giuseppe Lungarella Marco Idzko

J Immunol 2010 Jul 2;185(1):688-97. Epub 2010 Jun 2.

Department of Pulmonary Medicine, University Hospital, Freiburg, Germany.

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http://dx.doi.org/10.4049/jimmunol.0904042DOI Listing
July 2010

Extracellular adenosine triphosphate and chronic obstructive pulmonary disease.

Authors:
Marek Lommatzsch Sanja Cicko Tobias Müller Monica Lucattelli Kai Bratke Paul Stoll Melanie Grimm Thorsten Dürk Gernot Zissel Davide Ferrari Francesco Di Virgilio Stephan Sorichter Giuseppe Lungarella J Christian Virchow Marco Idzko

Am J Respir Crit Care Med 2010 May 21;181(9):928-34. Epub 2010 Jan 21.

Department of Pneumology, University of Rostock, Rostock, Germany.

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http://www.atsjournals.org/doi/abs/10.1164/rccm.200910-1506O
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May 2010

Functional and structural alterations in the endoplasmic reticulum and mitochondria during apoptosis triggered by C2-ceramide and CD95/APO-1/FAS receptor stimulation.

Authors:
Davide Ferrari Paolo Pinton Michelangelo Campanella Maria Giulia Callegari Cinzia Pizzirani Alessandro Rimessi Francesco Di Virgilio Tullio Pozzan Rosario Rizzuto

Biochem Biophys Res Commun 2010 Jan 24;391(1):575-81. Epub 2009 Nov 24.

Department of Experimental and Diagnostic Medicine, Section of General Pathology, Interdisciplinary Center for the Study of Inflammation and Emilia Romagna Laboratory BioPharmaNet, University of Ferrara, Ferrara, Italy.

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http://dx.doi.org/10.1016/j.bbrc.2009.11.101DOI Listing
January 2010

Dysfunctional inflammasome in Schnitzler's syndrome.

Authors:
Cinzia Pizzirani Simonetta Falzoni Marcello Govoni Renato La Corte Simona Donadei Francesco Di Virgilio Francesco Trotta Andrea Lo Monaco

Rheumatology (Oxford) 2009 Oct 20;48(10):1304-8. Epub 2009 Aug 20.

Department of Experimental and Diagnostic Medicine, Section of General Pathology, University of Ferrara, Ferrara, Italy.

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http://dx.doi.org/10.1093/rheumatology/kep222DOI Listing
October 2009

Extracellular ATP acting at the P2X7 receptor inhibits secretion of soluble HLA-G from human monocytes.

Authors:
Roberta Rizzo Davide Ferrari Loredana Melchiorri Marina Stignani Sara Gulinelli Olavio R Baricordi Francesco Di Virgilio

J Immunol 2009 Oct 11;183(7):4302-11. Epub 2009 Sep 11.

Department of Experimental and Diagnostic Medicine, Laboratory of Immunogenetics, Section of Medical Genetics, University of Ferrara, Via L. Borsari 46, Ferrara I-44100, Italy.

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http://www.jimmunol.org/content/183/7/4302.full.pdf
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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.0804265
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October 2009

Identification of novel immunosuppressive pathways paves the way for drug discovery.

Authors:
Francesco Di Virgilio Simon C Robson

Curr Opin Pharmacol 2009 Aug 20;9(4):445-6. Epub 2009 Jul 20.

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http://dx.doi.org/10.1016/j.coph.2009.06.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2756158PMC
August 2009

Extracellular nucleotides as negative modulators of immunity.

Authors:
Francesco Di Virgilio Jean-Marie Boeynaems Simon C Robson

Curr Opin Pharmacol 2009 Aug 21;9(4):507-13. Epub 2009 Jul 21.

Department of Experimental and Diagnostic Medicine, Section of General Pathology, University of Ferrara, Italy.

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http://dx.doi.org/10.1016/j.coph.2009.06.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158611PMC
August 2009

5-hydroxytryptamine modulates migration, cytokine and chemokine release and T-cell priming capacity of dendritic cells in vitro and in vivo.

Authors:
Tobias Müller Thorsten Dürk Britta Blumenthal Melanie Grimm Sanja Cicko Elisabeth Panther Stephan Sorichter Yared Herouy Francesco Di Virgilio Davide Ferrari Johannes Norgauer Marco Idzko

PLoS One 2009 Jul 31;4(7):e6453. Epub 2009 Jul 31.

Department of Pneumology, University Hospital Freiburg, Freiburg, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714071PMC
July 2009

P2X(7): a growth-promoting receptor-implications for cancer.

Authors:
Francesco Di Virgilio Davide Ferrari Elena Adinolfi

Purinergic Signal 2009 Jun 4;5(2):251-6. Epub 2009 Mar 4.

Department of Experimental and Diagnostic Medicine, Section of General Pathology, and Interdisciplinary Center for the Study of Inflammation (ICSI), University of Ferrara, Via Borsari 46, Ferrara, 44100, Italy,

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http://dx.doi.org/10.1007/s11302-009-9145-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2686832PMC
June 2009

Editorial.

Authors:
Francesco Di Virgilio James S Wiley

Purinergic Signal 2009 Jun;5(2):127-8

Department of Experimental and Diagnostic Medicine, Section of General Pathology, and Interdisciplinary Center for the Study of Inflammation (ICSI), University of Ferrara, Via Borsari 46, Ferrara, 44100, Italy,

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http://dx.doi.org/10.1007/s11302-009-9159-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2686833PMC
June 2009

Expression of the P2X7 receptor increases the Ca2+ content of the endoplasmic reticulum, activates NFATc1, and protects from apoptosis.

Authors:
Elena Adinolfi Maria Giulia Callegari Maria Cirillo Paolo Pinton Carlotta Giorgi Dario Cavagna Rosario Rizzuto Francesco Di Virgilio

J Biol Chem 2009 Apr 9;284(15):10120-8. Epub 2009 Feb 9.

Department of Experimental and Diagnostic Medicine, Section of General Pathology, and Interdisciplinary Center for the Study of Inflammation, University of Ferrara, via Borsari 46, 44100 Ferrara, Italy.

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http://dx.doi.org/10.1074/jbc.M805805200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2665066PMC
April 2009

Activation of microglia by amyloid {beta} requires P2X7 receptor expression.

Authors:
Juana M Sanz Paola Chiozzi Davide Ferrari Marilena Colaianna Marco Idzko Simonetta Falzoni Renato Fellin Luigia Trabace Francesco Di Virgilio

J Immunol 2009 Apr;182(7):4378-85

Department of Clinical and Experimental Medicine, University of Ferrara, Italy.

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http://dx.doi.org/10.4049/jimmunol.0803612DOI Listing
April 2009

1513A>C polymorphism in the P2X7 receptor gene in patients with papillary thyroid cancer: correlation with histological variants and clinical parameters.

Authors:
Angela Dardano Simonetta Falzoni Nadia Caraccio Antonio Polini Sara Tognini Anna Solini Piero Berti Francesco Di Virgilio Fabio Monzani

J Clin Endocrinol Metab 2009 Feb 18;94(2):695-8. Epub 2008 Nov 18.

Department of Internal Medicine, University of Pisa, via Roma 67, 56126 Pisa, Italy.

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http://dx.doi.org/10.1210/jc.2008-1322DOI Listing
February 2009

Purinergic signalling in inflammation of the central nervous system.

Authors:
Francesco Di Virgilio Stefania Ceruti Placido Bramanti Maria P Abbracchio

Trends Neurosci 2009 Feb 8;32(2):79-87. Epub 2009 Jan 8.

Department of Experimental and Diagnostic Medicine, Section of General Pathology, Interdisciplinary Center for the Study of Inflammation, University of Ferrara, 44100 Ferrara, Italy.

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http://dx.doi.org/10.1016/j.tins.2008.11.003DOI Listing
February 2009

The human cathelicidin LL-37 modulates the activities of the P2X7 receptor in a structure-dependent manner.

Authors:
Linda Tomasinsig Cinzia Pizzirani Barbara Skerlavaj Patrizia Pellegatti Sara Gulinelli Alessandro Tossi Francesco Di Virgilio Margherita Zanetti

J Biol Chem 2008 Nov 2;283(45):30471-81. Epub 2008 Sep 2.

Department of Biomedical Sciences and Technology, University of Udine, 33100 Udine, Italy.

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http://dx.doi.org/10.1074/jbc.M802185200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2662141PMC
November 2008

Activation of human alveolar macrophages via P2 receptors: coupling to intracellular Ca2+ increases and cytokine secretion.

Authors:
Daniel Myrtek Tobias Müller Verena Geyer Natalie Derr Davide Ferrari Gernot Zissel Thorsten Dürk Stephan Sorichter Werner Luttmann Michael Kuepper Johannes Norgauer Francesco Di Virgilio J Christian Virchow Marco Idzko

J Immunol 2008 Aug;181(3):2181-8

University Hospital Freiburg, Department of Pneumology, Freiburg, Germany.

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http://dx.doi.org/10.4049/jimmunol.181.3.2181DOI Listing
August 2008

Increased level of extracellular ATP at tumor sites: in vivo imaging with plasma membrane luciferase.

Authors:
Patrizia Pellegatti Lizzia Raffaghello Giovanna Bianchi Federica Piccardi Vito Pistoia Francesco Di Virgilio

PLoS One 2008 Jul 9;3(7):e2599. Epub 2008 Jul 9.

Department of Experimental and Diagnostic Medicine, Section of General Pathology, Interdisciplinary Center for the Study of Inflammation, University of Ferrara, Ferrara, Italy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2440522PMC
July 2008

First joint italian-german purine club meeting "progress in purinergic receptor pharmacology and function".

Authors:
Francesco Caciagli Francesco Di Virgilio

Purinergic Signal 2006 Nov 11;2(4):573-4. Epub 2006 Nov 11.

Department of Biomedical Sciences-Section of Pharmacology and Toxicology, University of Chieti-Medical School, Via dei Vestini 29, Pal.B, 66013, Chieti, Italy,

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http://dx.doi.org/10.1007/s11302-006-9029-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2096657PMC
November 2006

Purinergic mechanism in the immune system: A signal of danger for dendritic cells.

Authors:
Francesco Di Virgilio

Purinergic Signal 2005 Sep 29;1(3):205-9. Epub 2005 Jul 29.

Department of Experimental and Diagnostic Medicine, Section of General Pathology, and Interdisciplinary Center for the Study of Inflammation (ICSI), University of Ferrara, Ferrara, Italy,

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http://dx.doi.org/10.1007/s11302-005-6312-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2096539PMC
September 2005

P2X(7) receptor: Death or life?

Authors:
Elena Adinolfi Cinzia Pizzirani Marco Idzko Elisabeth Panther Johannes Norgauer Francesco Di Virgilio Davide Ferrari

Purinergic Signal 2005 Sep 29;1(3):219-27. Epub 2005 Jul 29.

Department of Experimental and Diagnostic Medicine, Section of General Pathology and Interdisciplinary Center for the Study of Inflammation (ICSI), University of Ferrara, Ferrara, Italy.

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http://dx.doi.org/10.1007/s11302-005-6322-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2096546PMC
September 2005