Francesco Bernardi

Francesco Bernardi

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Francesco Bernardi

Francesco Bernardi

Publications by authors named "Francesco Bernardi"

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Tailoring the CRISPR system to transactivate coagulation gene promoters in normal and mutated contexts.

Biochim Biophys Acta Gene Regul Mech 2019 Jun 18;1862(6):619-624. Epub 2019 Apr 18.

Department of Life Sciences and Biotechnology, University of Ferrara, Italy.

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http://dx.doi.org/10.1016/j.bbagrm.2019.04.002DOI Listing
June 2019

Coagulation Pathways in Neurological Diseases: Multiple Sclerosis.

Front Neurol 2019 24;10:409. Epub 2019 Apr 24.

Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, Buffalo Neuroimaging Analysis Center, University at Buffalo, State University of New York, Buffalo, NY, United States.

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http://dx.doi.org/10.3389/fneur.2019.00409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491577PMC
April 2019

Disease-causing variants of the conserved +2T of 5' splice sites can be rescued by engineered U1snRNAs.

Hum Mutat 2019 Jan 19;40(1):48-52. Epub 2018 Nov 19.

Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy.

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http://dx.doi.org/10.1002/humu.23680DOI Listing
January 2019

Plasma levels of soluble NCAM in multiple sclerosis.

J Neurol Sci 2019 01 28;396:36-41. Epub 2018 Oct 28.

Department of Biomedical and Specialty Surgical Sciences, University of Ferrara, Italy. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0022510X183043
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http://dx.doi.org/10.1016/j.jns.2018.10.023DOI Listing
January 2019

The carboxyl-terminal region of human coagulation factor X as a natural linker for fusion strategies.

Thromb Res 2019 01 9;173:4-11. Epub 2018 Nov 9.

Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00493848183060
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http://dx.doi.org/10.1016/j.thromres.2018.11.007DOI Listing
January 2019

Increased CCL18 plasma levels are associated with neurodegenerative MRI outcomes in multiple sclerosis patients.

Mult Scler Relat Disord 2018 Oct 7;25:37-42. Epub 2018 Jul 7.

Jacobs Comprehensive MS Treatment and Research Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA; Department of Pharmaceutical Sciences, State University of New York, Buffalo, NY, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22110348183021
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http://dx.doi.org/10.1016/j.msard.2018.07.009DOI Listing
October 2018

Secretion of wild-type factor IX upon readthrough over F9 pre-peptide nonsense mutations causing hemophilia B.

Hum Mutat 2018 05 17;39(5):702-708. Epub 2018 Feb 17.

Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy.

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http://dx.doi.org/10.1002/humu.23404DOI Listing
May 2018

Factor VII deficiency: Unveiling the cellular and molecular mechanisms underlying three model alterations of the enzyme catalytic domain.

Biochim Biophys Acta Mol Basis Dis 2018 Mar 12;1864(3):660-667. Epub 2017 Dec 12.

Department of Hematology, Oslo University Hospital, NO-0424 Oslo, Norway; Research Institute of Internal Medicine, Oslo University Hospital, NO-0424 Oslo, Norway.

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http://dx.doi.org/10.1016/j.bbadis.2017.12.016DOI Listing
March 2018

Correction of the Exon 2 Duplication in DMD Myoblasts by a Single CRISPR/Cas9 System.

Mol Ther Nucleic Acids 2017 Jun 10;7:11-19. Epub 2017 Feb 10.

Genethon, INSERM UMR951, 1 bis, rue de l'Internationale BP60, 91002 Evry Cedex, France; Department of Life Sciences and Biotechnology, University of Ferrara, Fossato di Mortara 74, 44121 Ferrara, Italy. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S21622531173013
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http://dx.doi.org/10.1016/j.omtn.2017.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363679PMC
June 2017

Exploring Splicing-Switching Molecules For Seckel Syndrome Therapy.

Biochim Biophys Acta Mol Basis Dis 2017 01 14;1863(1):15-20. Epub 2016 Sep 14.

Department of Life Sciences and Biotechnology, Section of Biochemistry and Molecular Biology, University of Ferrara, Via Fossato di Mortara 74, 44121 Ferrara, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2016.09.011DOI Listing
January 2017

An Exon-Specific U1snRNA Induces a Robust Factor IX Activity in Mice Expressing Multiple Human FIX Splicing Mutants.

Mol Ther Nucleic Acids 2016 Oct 4;5(10):e370. Epub 2016 Oct 4.

Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy.

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http://dx.doi.org/10.1038/mtna.2016.77DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095682PMC
October 2016

Regulation of a strong F9 cryptic 5'ss by intrinsic elements and by combination of tailored U1snRNAs with antisense oligonucleotides.

Hum Mol Genet 2015 Sep 10;24(17):4809-16. Epub 2015 Jun 10.

Department of Life Sciences and Biotechnology, University of Ferrara and LTTA, Ferrara, Italy and.

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http://dx.doi.org/10.1093/hmg/ddv205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527485PMC
September 2015

Coagulation factor VII variants resistant to inhibitory antibodies.

Thromb Haemost 2014 Nov 7;112(5):972-80. Epub 2014 Aug 7.

Prof. Francesco Bernardi, Department of Life Sciences and Biotechnology, University of Ferrara, Via Fossato di Mortara 74, 44121 Ferrara, Italy, Tel.: +39 0532 974425, Fax: +39 0532 974484, E-mail:

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http://dx.doi.org/10.1160/TH14-03-0198DOI Listing
November 2014

Calmodulin expression distinguishes the smooth muscle cell population of human carotid plaque.

Am J Pathol 2013 Sep 6;183(3):996-1009. Epub 2013 Jul 6.

Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland.

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http://dx.doi.org/10.1016/j.ajpath.2013.06.006DOI Listing
September 2013

Molecular basis of coagulation factor V deficiency caused by the R1698W inter-domain mutation.

Thromb Haemost 2013 Jul 25;110(1):31-8. Epub 2013 Apr 25.

Sara Calzavarini, PhD, Service and Central Laboratory of Hematology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Rue du Bugnon 46, CH-1011 Lausanne, Switzerland.

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http://dx.doi.org/10.1160/TH12-10-0780DOI Listing
July 2013

Individualized Theory of Mind (iToM): When Memory Modulates Empathy.

Front Psychol 2013 1;4. Epub 2013 Feb 1.

Dipartimento di Psicologia and Centro Studi e Ricerche in Neuroscienze Cognitive, Università di Bologna Bologna, Italy.

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http://dx.doi.org/10.3389/fpsyg.2013.00004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561727PMC
February 2013

Phytochemical analysis and cytotoxicity towards multidrug-resistant leukemia cells of essential oils derived from Lebanese medicinal plants.

Planta Med 2012 Dec 15;78(18):1927-31. Epub 2012 Nov 15.

Faculty of Sciences II, Lebanese University, Chemistry Department, Fanar, Beirut, Lebanon.

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http://dx.doi.org/10.1055/s-0032-1327896DOI Listing
December 2012

Ribosome readthrough accounts for secreted full-length factor IX in hemophilia B patients with nonsense mutations.

Hum Mutat 2012 Sep 11;33(9):1373-6. Epub 2012 Jun 11.

Dipartimento di Biochimica e Biologia Molecolare and LTTA Centre, Università di Ferrara, Italy.

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http://dx.doi.org/10.1002/humu.22120DOI Listing
September 2012

An exon-specific U1 small nuclear RNA (snRNA) strategy to correct splicing defects.

Hum Mol Genet 2012 Jun 23;21(11):2389-98. Epub 2012 Feb 23.

Human Molecular Genetics, International Centre for Genetic Engineering and Biotechnology, Trieste, Italy.

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https://academic.oup.com/hmg/article-lookup/doi/10.1093/hmg/
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http://dx.doi.org/10.1093/hmg/dds045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3349419PMC
June 2012

Functional genetics.

Thromb Res 2012 Mar 17;129(3):336-40. Epub 2011 Nov 17.

Department of Biochemistry and Molecular Biology, University of Ferrara, Ferrara, Italy.

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http://dx.doi.org/10.1016/j.thromres.2011.10.028DOI Listing
March 2012

The dominant-negative von Willebrand factor gene deletion p.P1127_C1948delinsR: molecular mechanism and modulation.

Blood 2010 Dec 27;116(24):5371-6. Epub 2010 Aug 27.

Department of Biochemistry and Molecular Biology, University of Ferrara, Ferrara.

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http://dx.doi.org/10.1182/blood-2010-02-268920DOI Listing
December 2010

Effective hemostasis during minor surgery in a case of hereditary combined deficiency of vitamin K-dependent clotting factors.

Clin Appl Thromb Hemost 2010 Apr 13;16(2):221-3. Epub 2009 Jan 13.

Haemophilia and Thrombosis Centre, University of L'Aquila, Ospedale San Salvatore, Via Vetoio 1, Coppito, L'Aquila, Italy.

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http://dx.doi.org/10.1177/1076029608330473DOI Listing
April 2010

Membrane binding and anticoagulant properties of protein S natural variants.

Thromb Res 2010 Feb 29;125(2):e33-9. Epub 2009 Oct 29.

Department of Biochemistry and Molecular Biology, ICSI, University of Ferrara, Ferrara, Italy.

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http://dx.doi.org/10.1016/j.thromres.2009.09.015DOI Listing
February 2010

Rescue of coagulation factor VII function by the U1+5A snRNA.

Blood 2009 Jun 22;113(25):6461-4. Epub 2009 Apr 22.

Department of Biochemistry, University of Ferrara, Italy.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2009-03-20
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http://dx.doi.org/10.1182/blood-2009-03-207613DOI Listing
June 2009

Factor VII Deficiency.

Semin Thromb Hemost 2009 Jun 13;35(4):400-6. Epub 2009 Jul 13.

Dipartimento di Medicina Interna e Sanità Pubblica, Università dell'Aquila, L'Aquila 67010, Italy.

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http://dx.doi.org/10.1055/s-0029-1225762DOI Listing
June 2009

Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants.

Authors:
Sekar Kathiresan Benjamin F Voight Shaun Purcell Kiran Musunuru Diego Ardissino Pier M Mannucci Sonia Anand James C Engert Nilesh J Samani Heribert Schunkert Jeanette Erdmann Muredach P Reilly Daniel J Rader Thomas Morgan John A Spertus Monika Stoll Domenico Girelli Pascal P McKeown Chris C Patterson David S Siscovick Christopher J O'Donnell Roberto Elosua Leena Peltonen Veikko Salomaa Stephen M Schwartz Olle Melander David Altshuler Diego Ardissino Pier Angelica Merlini Carlo Berzuini Luisa Bernardinelli Flora Peyvandi Marco Tubaro Patrizia Celli Maurizio Ferrario Raffaela Fetiveau Nicola Marziliano Giorgio Casari Michele Galli Flavio Ribichini Marco Rossi Francesco Bernardi Pietro Zonzin Alberto Piazza Pier M Mannucci Stephen M Schwartz David S Siscovick Jean Yee Yechiel Friedlander Roberto Elosua Jaume Marrugat Gavin Lucas Isaac Subirana Joan Sala Rafael Ramos Sekar Kathiresan James B Meigs Gordon Williams David M Nathan Calum A MacRae Christopher J O'Donnell Veikko Salomaa Aki S Havulinna Leena Peltonen Olle Melander Goran Berglund Benjamin F Voight Sekar Kathiresan Joel N Hirschhorn Rosanna Asselta Stefano Duga Marta Spreafico Kiran Musunuru Mark J Daly Shaun Purcell Benjamin F Voight Shaun Purcell James Nemesh Joshua M Korn Steven A McCarroll Stephen M Schwartz Jean Yee Sekar Kathiresan Gavin Lucas Isaac Subirana Roberto Elosua Aarti Surti Candace Guiducci Lauren Gianniny Daniel Mirel Melissa Parkin Noel Burtt Stacey B Gabriel Nilesh J Samani John R Thompson Peter S Braund Benjamin J Wright Anthony J Balmforth Stephen G Ball Alistair S Hall Heribert Schunkert Jeanette Erdmann Patrick Linsel-Nitschke Wolfgang Lieb Andreas Ziegler Inke König Christian Hengstenberg Marcus Fischer Klaus Stark Anika Grosshennig Michael Preuss H-Erich Wichmann Stefan Schreiber Heribert Schunkert Nilesh J Samani Jeanette Erdmann Willem Ouwehand Christian Hengstenberg Panos Deloukas Michael Scholz Francois Cambien Muredach P Reilly Mingyao Li Zhen Chen Robert Wilensky William Matthai Atif Qasim Hakon H Hakonarson Joe Devaney Mary-Susan Burnett Augusto D Pichard Kenneth M Kent Lowell Satler Joseph M Lindsay Ron Waksman Christopher W Knouff Dawn M Waterworth Max C Walker Vincent Mooser Stephen E Epstein Daniel J Rader Thomas Scheffold Klaus Berger Monika Stoll Andreas Huge Domenico Girelli Nicola Martinelli Oliviero Olivieri Roberto Corrocher Thomas Morgan John A Spertus Pascal McKeown Chris C Patterson Heribert Schunkert Erdmann Erdmann Patrick Linsel-Nitschke Wolfgang Lieb Andreas Ziegler Inke R König Christian Hengstenberg Marcus Fischer Klaus Stark Anika Grosshennig Michael Preuss H-Erich Wichmann Stefan Schreiber Hilma Hólm Gudmar Thorleifsson Unnur Thorsteinsdottir Kari Stefansson James C Engert Ron Do Changchun Xie Sonia Anand Sekar Kathiresan Diego Ardissino Pier M Mannucci David Siscovick Christopher J O'Donnell Nilesh J Samani Olle Melander Roberto Elosua Leena Peltonen Veikko Salomaa Stephen M Schwartz David Altshuler

Nat Genet 2009 Mar 8;41(3):334-41. Epub 2009 Feb 8.

Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1038/ng.327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2681011PMC
March 2009

Evidence for an overlapping role of CLOCK and NPAS2 transcription factors in liver circadian oscillators.

Mol Cell Biol 2008 May 3;28(9):3070-5. Epub 2008 Mar 3.

Dipartimento di Biochimica e Biologia Molecolare, Università di Ferrara, Via Fossato di Mortara 74, 44100 Ferrara, Italia.

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http://dx.doi.org/10.1128/MCB.01931-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2293078PMC
May 2008

U1-snRNA-mediated rescue of mRNA processing in severe factor VII deficiency.

Blood 2008 Mar 21;111(5):2681-4. Epub 2007 Dec 21.

Department of Biochemistry and Molecular Biology, University of Ferrara, Via Fossato di Mortara 74, Ferrara, Italy.

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http://dx.doi.org/10.1182/blood-2007-10-117440DOI Listing
March 2008

Characterization of anti-coagulant properties of prenylated coumarin ferulenol.

Biochim Biophys Acta 2007 Oct 12;1770(10):1437-40. Epub 2007 Jul 12.

Dipartimento di Biochimica e Biologia Molecolare, Università di Ferrara, Italy.

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http://dx.doi.org/10.1016/j.bbagen.2007.06.013DOI Listing
October 2007

Temporal variations of coagulation factor VII activity in mice are influenced by lighting regime.

Chronobiol Int 2007 ;24(2):305-13

Department of Biology and Evolution and Neuroscience Centre, University of Ferrara, Ferrara, Italy.

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http://www.tandfonline.com/doi/full/10.1080/0742052070128230
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http://dx.doi.org/10.1080/07420520701282307DOI Listing
June 2007

Increased factor VIII coagulant activity levels in male carriers of the factor V R2 polymorphism.

Blood Coagul Fibrinolysis 2007 Mar;18(2):125-9

Department of Clinical and Experimental Medicine, University of Verona, Italy.

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http://dx.doi.org/10.1097/MBC.0b013e328011c06dDOI Listing
March 2007

Intracellular evaluation of ER targeting elucidates a mild form of inherited coagulation deficiency.

Mol Med 2006 Jul-Aug;12(7-8):137-42

Department of Biochemistry and Molecular Biology, University of Ferrara, Via Fossato di Mortara 74, Ferrara, Italy.

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http://dx.doi.org/10.2119/2005-00040.RizzottoDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1626593PMC
January 2007

An underestimated combination of opposites resulting in enhanced thrombotic tendency.

Blood 2005 Oct 16;106(7):2363-5. Epub 2005 Jun 16.

Department of Medical and Surgical Sciences, Second Chair of Internal Medicine, University of Padua Medical School, Padua, Italy.

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http://dx.doi.org/10.1182/blood-2005-04-1461DOI Listing
October 2005

Circadian rhythms in mouse blood coagulation.

J Biol Rhythms 2005 Jun;20(3):219-24

Department of Biology and Neuroscience Centre, University of Ferrara, Ferrara, Italy.

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http://dx.doi.org/10.1177/0748730405275654DOI Listing
June 2005

Daily and circadian rhythms of tissue factor pathway inhibitor and factor VII activity.

Arterioscler Thromb Vasc Biol 2005 Mar 16;25(3):646-9. Epub 2004 Dec 16.

Deparment of di Biochimica e Biologia Molecolare, Università di Ferrara, Via L. Borsari 46, 44100 Ferrara, Italia.

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http://dx.doi.org/10.1161/01.ATV.0000153140.13148.e0DOI Listing
March 2005

Modulation of factor V levels in plasma by polymorphisms in the C2 domain.

Arterioscler Thromb Vasc Biol 2004 Jan 1;24(1):200-6. Epub 2003 Dec 1.

Department of Biochemistry and Molecular Biology, Ferrara University, Italy.

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http://dx.doi.org/10.1161/01.ATV.0000109750.34073.f6DOI Listing
January 2004

Coinheritance of Factor V (FV) Leiden enhances thrombin formation and is associated with a mild bleeding phenotype in patients homozygous for the FVII 9726+5G>A (FVII Lazio) mutation.

Blood 2003 Dec 24;102(12):4014-20. Epub 2003 Jul 24.

Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, PO Box 616, 6200 MD Maastricht, the Netherlands.

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http://dx.doi.org/10.1182/blood-2003-04-1199DOI Listing
December 2003

Modulation of thrombophilia genes by environmental factors.

Pathophysiol Haemost Thromb 2002 Sep-Dec;32(5-6):335-7

Dipartimento di Biochimica e Biologia Molecolare, Università degli Studi di Ferrara, Ferrara, Italy.

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http://dx.doi.org/10.1159/000076692DOI Listing
October 2003

The factor V HR2 haplotype and the risk of venous thrombosis: a meta-analysis.

Haematologica 2003 Oct;88(10):1182-9

Department of Hematology, San Bortolo Hospital, Vicenza, Italy.

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October 2003

Role of family history in identifying women with thrombophilia and higher risk of venous thromboembolism during oral contraception.

Arch Intern Med 2003 May;163(9):1105-9

Division of Angiology, Cardiovascular Department, Unità di Ricerca Clinica sulla Trombofilia Marino Golinelli, University Hospital S. Orsola-Malpighi, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy.

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http://dx.doi.org/10.1001/archinte.163.9.1105DOI Listing
May 2003

Asymptomatic carriership of factor V Leiden and genotypes of the fibrinogen gene cluster.

Br J Haematol 2003 May;121(4):632-8

Dipartimento di Biochimica e Biologia Molecolare, Università di Ferrara, Unità di Ricerca Clinica sulla Trombofilia 'Marino Golinelli', Divisione di Angiologia, Azienda Ospedaliera di Bologna, Policlinico S.Orsola-Malpighi, Bologna, Italia.

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May 2003

Factor VII mutant V154G models a zymogen-like form of factor VIIa.

Biochem J 2003 Feb;369(Pt 3):563-71

Department of Biochemistry and Molecular Biology, University of Ferrara, Via Luigi Borsari, 46 Ferrara 44100, Italy.

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http://biochemj.org/lookup/doi/10.1042/bj20020888
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http://dx.doi.org/10.1042/BJ20020888DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1223097PMC
February 2003

Impaired prothrombinase activity of factor X Gly381Asp results in severe familial CRM+ FX deficiency.

Thromb Haemost 2003 Feb;89(2):243-8

Department of Biochemistry and Molecular Biology, University of Ferara, Ferrara, Italy.

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February 2003

Modulation of Thrombophilia Genes by Environmental Factors.

Pathophysiol Haemost Thromb 2002 ;32(5-6):329-332

Dipartimento di Biochimica e Biologia Molecolare, Università degli Studi di Ferrara, Ferrara, Italy.

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http://dx.doi.org/10.1159/000073592DOI Listing
January 2002