Francesco Beguinot

Francesco Beguinot

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Francesco Beguinot

Publications by authors named "Francesco Beguinot"

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Role of the HIF-1α/Nur77 axis in the regulation of the tyrosine hydroxylase expression by insulin in PC12 cells.

J Cell Physiol 2019 Jul 7;234(7):11861-11870. Epub 2018 Dec 7.

Department of Translational Medicine, Federico II University of Naples and URT "Genomic of Diabetes" of Institute of Experimental Endocrinology and Oncology, National Council of Research (CNR), Naples, Italy.

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http://dx.doi.org/10.1002/jcp.27898DOI Listing
July 2019

Methylglyoxal accumulation de-regulates HoxA5 expression, thereby impairing angiogenesis in glyoxalase 1 knock-down mouse aortic endothelial cells.

Biochim Biophys Acta Mol Basis Dis 2019 Jan 18;1865(1):73-85. Epub 2018 Oct 18.

URT of the Institute of Experimental Endocrinology and Oncology "G. Salvatore", National Council of Research, Naples, Italy; Department of Translational Medical Sciences, University of Naples "Federico II", Naples, Italy. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09254439183039
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http://dx.doi.org/10.1016/j.bbadis.2018.10.014DOI Listing
January 2019

High-fat diet unveils an enhancer element at the Ped/Pea-15 gene responsible for epigenetic memory in skeletal muscle.

Metabolism 2018 10 19;87:70-79. Epub 2018 Jun 19.

URT Genomics of Diabetes-IEOS, CNR/Department of Translational Medicine, "Federico II" University Medical School of Napoli, via Sergio Pansini 5, 80131 Naples, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.metabol.2018.06.001DOI Listing
October 2018

Oleic acid promotes prostate cancer malignant phenotype via the G protein-coupled receptor FFA1/GPR40.

J Cell Physiol 2018 Sep 16;233(9):7367-7378. Epub 2018 Apr 16.

Department of Medical and Translational Sciences of the University of Naples "Federico II" & URT dell'Istituto di Endocrinologia e Oncologia Sperimentale "Gaetano Salvatore", Consiglio Nazionale delle Ricerche, Naples, Italy.

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http://dx.doi.org/10.1002/jcp.26572DOI Listing
September 2018

Prep1 Deficiency Affects Olfactory Perception and Feeding Behavior by Impairing BDNF-TrkB Mediated Neurotrophic Signaling.

Mol Neurobiol 2018 Aug 18;55(8):6801-6815. Epub 2018 Jan 18.

Department of Translational Medical Science, "Federico II" University of Naples and URT "Genomics of Diabetes", Institute of Experimental Endocrinology and Oncology of CNR, Via Pansini 5, 80131, Naples, Italy.

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http://dx.doi.org/10.1007/s12035-018-0873-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061220PMC
August 2018

Prep1, A Homeodomain Transcription Factor Involved in Glucose and Lipid Metabolism.

Front Endocrinol (Lausanne) 2018 28;9:346. Epub 2018 Jun 28.

Department of Translational Medicine, Federico II University of Naples, Naples, Italy.

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http://dx.doi.org/10.3389/fendo.2018.00346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032887PMC
June 2018

Prep1 deficiency improves metabolic response in white adipose tissue.

Biochim Biophys Acta Mol Cell Biol Lipids 2018 May 21;1863(5):515-525. Epub 2018 Feb 21.

Department of Translational Medicine, Federico II University of Naples and URT "Genomic of Diabetes" of Institute of Experimental Endocrinology and Oncology, National Council of Research (CNR), Naples, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bbalip.2018.02.005DOI Listing
May 2018

The Destiny of Glucose from a MicroRNA Perspective.

Front Endocrinol (Lausanne) 2018 26;9:46. Epub 2018 Feb 26.

Istituto per l'Endocrinologia e l'Oncologia Sperimentale "Gaetano Salvatore" - CNR, Naples, Italy.

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http://dx.doi.org/10.3389/fendo.2018.00046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834423PMC
February 2018

The SGK1 inhibitor SI113 induces autophagy, apoptosis, and endoplasmic reticulum stress in endometrial cancer cells.

J Cell Physiol 2017 Dec 27;232(12):3735-3743. Epub 2017 Apr 27.

Department of Medical and Translational Sciences of the University of Naples "Federico II" & URT dell'Istituto di Endocrinologia e Oncologia Sperimentale 'Gaetano Salvatore', Consiglio Nazionale delle Ricerche, Naples, Italy.

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http://dx.doi.org/10.1002/jcp.25850DOI Listing
December 2017

Glucose impairs tamoxifen responsiveness modulating connective tissue growth factor in breast cancer cells.

Oncotarget 2017 Dec 20;8(65):109000-109017. Epub 2017 Nov 20.

Department of Translational Medicine, University of Naples "Federico II" & URT "Genomic of Diabetes" of Institute of Experimental Endocrinology and Oncology "G. Salvatore", National Council of Research (CNR), Naples 80131, Italy.

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http://dx.doi.org/10.18632/oncotarget.22552DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5752499PMC
December 2017

A peptide antagonist of Prep1-p160 interaction improves ceramide-induced insulin resistance in skeletal muscle cells.

Oncotarget 2017 Sep 30;8(42):71845-71858. Epub 2017 May 30.

Department of Translational Medicine, Federico II University of Naples and URT "Genomic of Diabetes" of Institute of Experimental Endocrinology and Oncology, National Council of Research (CNR), Naples, Italy.

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http://dx.doi.org/10.18632/oncotarget.18286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641094PMC
September 2017

Targetting PED/PEA-15 for diabetes treatment.

Expert Opin Ther Targets 2017 Jun 21;21(6):571-581. Epub 2017 Apr 21.

a National Council of Research , URT of the Institute of Experimental Endocrinology and Oncology "G. Salvatore" , Naples , Italy.

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http://dx.doi.org/10.1080/14728222.2017.1317749DOI Listing
June 2017

The role of miR-190a in methylglyoxal-induced insulin resistance in endothelial cells.

Biochim Biophys Acta Mol Basis Dis 2017 02 15;1863(2):440-449. Epub 2016 Nov 15.

URT of the Institute of Experimental Endocrinology and Oncology "G. Salvatore", National Council of Research, Naples, Italy; Department of Translational Medical Sciences, University of Naples "Federico II", Naples, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2016.11.018DOI Listing
February 2017

Methylglyoxal-Glyoxalase 1 Balance: The Root of Vascular Damage.

Int J Mol Sci 2017 Jan 18;18(1). Epub 2017 Jan 18.

Research Unit (URT) of the Institute of Experimental Endocrinology and Oncology "G. Salvatore", National Council of Research, 80131 Naples, Italy.

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http://dx.doi.org/10.3390/ijms18010188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5297820PMC
January 2017

Parkinson-like phenotype in insulin-resistant PED/PEA-15 transgenic mice.

Sci Rep 2016 07 18;6:29967. Epub 2016 Jul 18.

URT- Genomica del Diabete, Istituto di Endocrinologia ed Oncologia Sperimentale (IEOS-CNR), Naples, Italy.

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http://dx.doi.org/10.1038/srep29967DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947959PMC
July 2016

Circulating miRNAs as intercellular messengers, potential biomarkers and therapeutic targets for Type 2 diabetes.

Epigenomics 2015 ;7(4):653-67

Dipartimento di Scienze Mediche Traslazionali dell'Università di Napoli 'Federico II', Naples, Italy.

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http://dx.doi.org/10.2217/epi.15.18DOI Listing
June 2016

Pathologic endoplasmic reticulum stress induced by glucotoxic insults inhibits adipocyte differentiation and induces an inflammatory phenotype.

Biochim Biophys Acta 2016 Jun 2;1863(6 Pt A):1146-56. Epub 2016 Mar 2.

Dipartimento di Scienze e Tecnologie Biologiche ed Ambientali, Università del Salento, Strada Monteroni, 73100 Lecce, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bbamcr.2016.02.019DOI Listing
June 2016

Understanding type 2 diabetes: from genetics to epigenetics.

Acta Diabetol 2015 Oct 5;52(5):821-7. Epub 2015 Apr 5.

Dipartimento di Scienze Mediche Traslazionali, "Federico II" University of Naples Medical School, Naples, Italy.

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http://link.springer.com/10.1007/s00592-015-0741-0
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http://dx.doi.org/10.1007/s00592-015-0741-0DOI Listing
October 2015

PED/PEA-15 inhibits hydrogen peroxide-induced apoptosis in Ins-1E pancreatic beta-cells via PLD-1.

PLoS One 2014 9;9(12):e113655. Epub 2014 Dec 9.

Dipartimento di Scienze Mediche e Traslazionali dell'Università di Napoli "Federico II", Naples, Italy; URT dell'Istituto di Endocrinologia e Oncologia Sperimentale Gaetano Salvatore, Consiglio Nazionale delle Ricerche, Naples, Italy.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0113655PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260953PMC
September 2015

Regulatory T cells, inflammation, and endoplasmic reticulum stress in women with defective endometrial receptivity.

Fertil Steril 2015 Jun 29;103(6):1579-86.e1. Epub 2015 Apr 29.

Dipartimento di Scienze Mediche Traslazionali and Istituto di Endocrinologia ed Oncologia Sperimentale "G. Salvatore" CNR, Università "Federico II," Naples, Italy. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00150282150021
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http://dx.doi.org/10.1016/j.fertnstert.2015.03.014DOI Listing
June 2015

Bisphenol-A impairs insulin action and up-regulates inflammatory pathways in human subcutaneous adipocytes and 3T3-L1 cells.

PLoS One 2013 9;8(12):e82099. Epub 2013 Dec 9.

Istituto di Endocrinologia ed Oncologia Sperimentale (IEOS-CNR), Naples, Italy ; Dipartimento di Scienze Mediche Traslazionali, Università degli Studi di Napoli "Federico II", Naples, Italy.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0082099PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857211PMC
October 2014

GRP78 mediates cell growth and invasiveness in endometrial cancer.

J Cell Physiol 2014 Oct;229(10):1417-26

Department of Molecular Medicine and Medical Biotechnologies & Institute of Endocrinology and Molecular Oncology of CNR, University "Federico II", Naples, Italy.

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http://dx.doi.org/10.1002/jcp.24578DOI Listing
October 2014

Methylglyoxal impairs endothelial insulin sensitivity both in vitro and in vivo.

Diabetologia 2014 Jul 24;57(7):1485-94. Epub 2014 Apr 24.

Institute of Experimental Endocrinology and Oncology 'G. Salvatore', National Council of Research, Via Pansini 5, 80131, Naples, Italy.

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http://link.springer.com/10.1007/s00125-014-3243-7
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http://dx.doi.org/10.1007/s00125-014-3243-7DOI Listing
July 2014

Transient covalent interactions of newly synthesized thyroglobulin with oxidoreductases of the endoplasmic reticulum.

J Biol Chem 2014 Apr 5;289(16):11488-96. Epub 2014 Mar 5.

From the Laboratorio di Patologia Generale, Dipartimento di Scienze e Tecnologie Biologiche ed Ambientali, Università del Salento, 73100 Lecce, Italy.

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http://dx.doi.org/10.1074/jbc.M113.520767DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036284PMC
April 2014

Personalized medicine and type 2 diabetes: lesson from epigenetics.

Epigenomics 2014 Apr;6(2):229-38

Dipartimento di Scienze Mediche Traslazionali, 'Federico II' University of Naples Medical School & Istituto per l' Endocrinologia e l' Oncologia Sperimentale del CNR, Via Sergio Pansini, 5 - Naples, 80131, Italy.

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http://dx.doi.org/10.2217/epi.14.10DOI Listing
April 2014

PREP1 deficiency downregulates hepatic lipogenesis and attenuates steatohepatitis in mice.

Diabetologia 2013 Dec 20;56(12):2713-22. Epub 2013 Sep 20.

Department of Translational Medical Sciences, 'Federico II' University of Naples and Institute of Experimental Endocrinology and Oncology, National Council of Research, Via Pansini 5, 80131, Naples, Italy.

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http://dx.doi.org/10.1007/s00125-013-3053-3DOI Listing
December 2013

Adenoviral gene transfer of PLD1-D4 enhances insulin sensitivity in mice by disrupting phospholipase D1 interaction with PED/PEA-15.

PLoS One 2013 9;8(4):e60555. Epub 2013 Apr 9.

Dipartimento di Scienze Mediche e Traslazionali, Università di Napoli Federico II and Istituto di Endocrinologia e Oncologia Sperimentale Gaetano Salvatore, Consiglio Nazionale delle Ricerche, Naples, Italy.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0060555PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3621763PMC
October 2013

Cytotoxicity of dental resin composites: an in vitro evaluation.

J Appl Toxicol 2013 Jun 26;33(6):451-7. Epub 2011 Nov 26.

School of Dentistry, University of Naples Federico II, Naples, Italy.

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http://dx.doi.org/10.1002/jat.1765DOI Listing
June 2013

Measurement of glucose homeostasis in vivo: glucose and insulin tolerance tests.

Methods Mol Biol 2012 ;933:219-28

Dipartimento di Biologia e Patologia Cellulare e Molecolare and Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Federico II University of Naples, Naples, Italy.

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http://dx.doi.org/10.1007/978-1-62703-068-7_14DOI Listing
January 2013

Inhibition of autophagy enhances the effects of E1A-defective oncolytic adenovirus dl922-947 against glioma cells in vitro and in vivo.

Hum Gene Ther 2012 Jun 5;23(6):623-34. Epub 2012 Jun 5.

Dipartimento di Biologia e Patologia Cellulare e Molecolare, Università Federico II, 80131, Naples, Italy.

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http://dx.doi.org/10.1089/hum.2011.120DOI Listing
June 2012

Clozapine impairs insulin action by up-regulating Akt phosphorylation and Ped/Pea-15 protein abundance.

J Cell Physiol 2012 Apr;227(4):1485-92

Dipartimento di Neuroscienze, Sezione di Psichiatria, Laboratorio di Psichiatria Molecolare, University of Napoli Federico II, Napoli, Italy.

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http://dx.doi.org/10.1002/jcp.22864DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306790PMC
April 2012

Endoplasmic reticulum stress is activated in endometrial adenocarcinoma.

Gynecol Oncol 2012 Apr 4;125(1):220-5. Epub 2011 Dec 4.

Department of Obstetrics and Gynecology, University Federico II, Naples, Italy.

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http://dx.doi.org/10.1016/j.ygyno.2011.11.045DOI Listing
April 2012

Age-related impairment in insulin release: the essential role of β(2)-adrenergic receptor.

Diabetes 2012 Mar 7;61(3):692-701. Epub 2012 Feb 7.

Department of Clinical Medicine, Cardiovascular & Immunologic Sciences, Federico II University of Naples, Naples, Italy.

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http://dx.doi.org/10.2337/db11-1027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282797PMC
March 2012

Serum 25-Hydroxyvitamin D Levels, phosphoprotein enriched in diabetes gene product (PED/PEA-15) and leptin-to-adiponectin ratio in women with PCOS.

Nutr Metab (Lond) 2011 Nov 23;8:84. Epub 2011 Nov 23.

Department of Molecular and Clinical Endocrinology and Oncology, Division of Endocrinology, University Federico II of Naples, Via S, Pansini 5, Naples, 80131, Italy.

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http://dx.doi.org/10.1186/1743-7075-8-84DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293764PMC
November 2011

Tyr phosphatase-mediated P-ERK inhibition suppresses senescence in EIA + v-raf transformed cells, which, paradoxically, are apoptosis-protected in a MEK-dependent manner.

Neoplasia 2011 Feb;13(2):120-30

Dipartimento di Scienze e Tecnologie Biologiche ed Ambientali, Facoltà di Scienze Matematiche Fisiche e Naturali, Università degli Studi del Salento, Lecce, Italy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033591PMC
February 2011

Prep1 controls insulin glucoregulatory function in liver by transcriptional targeting of SHP1 tyrosine phosphatase.

Diabetes 2011 01 23;60(1):138-47. Epub 2010 Sep 23.

Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Università degli Studi di Napoli Federico II, Naples, Italy.

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http://dx.doi.org/10.2337/db10-0860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012165PMC
January 2011

Residues 762-801 of PLD1 mediate the interaction with PED/PEA15.

Mol Biosyst 2010 Oct 11;6(10):2039-48. Epub 2010 Aug 11.

Istituto di Biostrutture e Bioimmagini, CNR, via Mezzocannone 16, 80134 Napoli, Italy.

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http://dx.doi.org/10.1039/c005272hDOI Listing
October 2010

PED/PEA-15 modulates coxsackievirus-adenovirus receptor expression and adenoviral infectivity via ERK-mediated signals in glioma cells.

Hum Gene Ther 2010 Sep;21(9):1067-76

Dipartimento di Biologia e Patologia Cellulare e Molecolare, Università Federico II, Naples, Italy.

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http://dx.doi.org/10.1089/hum.2009.181DOI Listing
September 2010

Selective disruption of insulin-like growth factor-1 (IGF-1) signaling via phosphoinositide-dependent kinase-1 prevents the protective effect of IGF-1 on human cancer cell death.

J Biol Chem 2010 Feb 31;285(9):6563-72. Epub 2009 Dec 31.

Dipartimento di Biologia e Patologia Cellulare e Molecolare and Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Università di Napoli Federico II, 80131 Naples, Italy.

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http://dx.doi.org/10.1074/jbc.M109.097410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2825452PMC
February 2010

Frontiers: PED/PEA-15, a multifunctional protein controlling cell survival and glucose metabolism.

Am J Physiol Endocrinol Metab 2009 Sep 16;297(3):E592-601. Epub 2009 Jun 16.

Dept. of Cellular and Molecular Biology and Pathology, Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Federico II Univ. of Naples, Naples, Italy.

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http://dx.doi.org/10.1152/ajpendo.00228.2009DOI Listing
September 2009

The cannabinoid CB1 receptor antagonist rimonabant stimulates 2-deoxyglucose uptake in skeletal muscle cells by regulating the expression of phosphatidylinositol-3-kinase.

Mol Pharmacol 2008 Dec 18;74(6):1678-86. Epub 2008 Sep 18.

Dipartimento di Biologia e Patologia Cellulare e Molecolare & Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Università degli Studi di Napoli Federico II, Napoli, Italy.

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http://dx.doi.org/10.1124/mol.108.049205DOI Listing
December 2008

In skeletal muscle advanced glycation end products (AGEs) inhibit insulin action and induce the formation of multimolecular complexes including the receptor for AGEs.

J Biol Chem 2008 Dec 27;283(52):36088-99. Epub 2008 Oct 27.

Dipartimento di Biologia e Patologia Cellulare e Molecolare and Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Università degli Studi di Napoli Federico II, Naples 80131, Italy.

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http://dx.doi.org/10.1074/jbc.M801698200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2662288PMC
December 2008

Prep1 deficiency induces protection from diabetes and increased insulin sensitivity through a p160-mediated mechanism.

Mol Cell Biol 2008 Sep 21;28(18):5634-45. Epub 2008 Jul 21.

Dipartimento di Biologia e Patologia Cellulare e Molecolare, Università di Napoli Federico II, Via Sergio Pansini, 5, Naples 80131, Italy.

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http://dx.doi.org/10.1128/MCB.00117-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2546928PMC
September 2008

Targeting of PED/PEA-15 molecular interaction with phospholipase D1 enhances insulin sensitivity in skeletal muscle cells.

J Biol Chem 2008 Aug 9;283(31):21769-78. Epub 2008 Jun 9.

Istituto di Biostrutture e Bioimmagini and Istituto di Endocrinologia e Oncologia Sperimentale Gaetano Salvatore, Consiglio Nazionale delle Ricerche, Naples, Italy.

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http://dx.doi.org/10.1074/jbc.M803771200DOI Listing
August 2008

Expression and purification of the D4 region of PLD1 and characterization of its interaction with PED-PEA15.

Protein Expr Purif 2008 Jun 29;59(2):302-8. Epub 2008 Feb 29.

Istituto di Biostrutture e Bioimmagini (IBB), CNR, via Mezzocannone 16, 80134 Napoli, Italy.

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http://dx.doi.org/10.1016/j.pep.2008.02.012DOI Listing
June 2008

Atypical protein kinase C dysfunction and the metabolic syndrome.

Trends Endocrinol Metab 2008 Mar 21;19(2):39-41. Epub 2008 Feb 21.

Dipartimento di Biologia e Patologia Cellulare e Molecolare, Federico II University of Naples Medical School, Via Sergio Pansini 5, Naples, Italy.

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http://dx.doi.org/10.1016/j.tem.2007.11.005DOI Listing
March 2008

ER stress is associated with dedifferentiation and an epithelial-to-mesenchymal transition-like phenotype in PC Cl3 thyroid cells.

J Cell Sci 2008 Feb 22;121(Pt 4):477-86. Epub 2008 Jan 22.

Istituto di Endocrinologia ed Oncologia Sperimentale G Salvatore, Via S Pansini 5, Napoli, Italy.

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http://dx.doi.org/10.1242/jcs.017202DOI Listing
February 2008

Glucose regulates diacylglycerol intracellular levels and protein kinase C activity by modulating diacylglycerol kinase subcellular localization.

J Biol Chem 2007 Nov 3;282(44):31835-43. Epub 2007 Aug 3.

Dipartimento di Biologia e Patologia Cellulare e Molecolare & Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Federico II University of Naples, Via Pansini 5, Naples 80131, Italy.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M702481200
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http://dx.doi.org/10.1074/jbc.M702481200DOI Listing
November 2007

Phorbol esters induce intracellular accumulation of the anti-apoptotic protein PED/PEA-15 by preventing ubiquitinylation and proteasomal degradation.

J Biol Chem 2007 Mar 16;282(12):8648-57. Epub 2007 Jan 16.

Dipartimento di Biologia e Patologia cellulare e Molecolare (DBPCM), Federico II University of Naples, Via Pansini 5, 80131 Naples, Italy.

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http://dx.doi.org/10.1074/jbc.M608359200DOI Listing
March 2007

PTEN targeting: the search for novel insulin sensitisers provides new insight into obesity research.

Diabetologia 2007 Feb;50(2):247-9

Department of Cellular and Molecular Biology and Pathology, University of Naples Federico II, 5 via Sergio Pansini, Naples, 80131, Italy.

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http://dx.doi.org/10.1007/s00125-006-0547-2DOI Listing
February 2007

Protein kinase C-alpha regulates insulin action and degradation by interacting with insulin receptor substrate-1 and 14-3-3 epsilon.

J Biol Chem 2005 Dec 10;280(49):40642-9. Epub 2005 Oct 10.

Dipartimento di Biologia e Patologia Cellulare e Molecolare and Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Federico II University of Naples, Italy.

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http://dx.doi.org/10.1074/jbc.M508570200DOI Listing
December 2005

Raised expression of the antiapoptotic protein ped/pea-15 increases susceptibility to chemically induced skin tumor development.

Oncogene 2005 Oct;24(47):7012-21

Dipartimento di Biologia e Patologia Cellulare e Molecolare, Università di Napoli Federico II, Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Via Sergio Pansini, 5, Naples 80131, Italy.

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http://dx.doi.org/10.1038/sj.onc.1208871DOI Listing
October 2005

Omi/HtrA2 promotes cell death by binding and degrading the anti-apoptotic protein ped/pea-15.

J Biol Chem 2004 Nov 24;279(45):46566-72. Epub 2004 Aug 24.

Dipartimento di Biologia e Patologia Cellulare e Molecolare and Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Università degli Studi di Napoli Federico II, Naples 80131, Italy.

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http://dx.doi.org/10.1074/jbc.M406317200DOI Listing
November 2004

Protein kinase C-zeta and protein kinase B regulate distinct steps of insulin endocytosis and intracellular sorting.

J Biol Chem 2004 Mar 6;279(12):11137-45. Epub 2004 Jan 6.

Dipartimento di Biologia e Patologia Cellulare e Molecolare L. Califano and Istituto di Endocrinologia ed Oncologia Sperimentale del C.N.R., Università degli Studi di Napoli Federico II, Via S. Pansini, 5, 80131 Naples, Italy.

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http://dx.doi.org/10.1074/jbc.M308751200DOI Listing
March 2004

Human glycated albumin affects glucose metabolism in L6 skeletal muscle cells by impairing insulin-induced insulin receptor substrate (IRS) signaling through a protein kinase C alpha-mediated mechanism.

J Biol Chem 2003 Nov 11;278(48):47376-87. Epub 2003 Sep 11.

Dipartimento di Biologia e Patologia Cellulare e Molecolare & Centro di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Università di Napoli Federico II, Via S. Pansini, 5, 80131 Naples, Italy.

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http://dx.doi.org/10.1074/jbc.M301088200DOI Listing
November 2003

Protein kinase B/Akt binds and phosphorylates PED/PEA-15, stabilizing its antiapoptotic action.

Mol Cell Biol 2003 Jul;23(13):4511-21

Dipartimento di Biologia e Patologia Cellulare e Molecolare and Istituto di Endocrinologia ed Oncologia Sperimentale del C.N.R., Federico II University of Naples, Naples, Italy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC164852PMC
July 2003

Protein kinase Calpha activation by RET: evidence for a negative feedback mechanism controlling RET tyrosine kinase.

Oncogene 2003 May;22(19):2942-9

Dipartimento di Biologia e Patologia Cellulare e Molecolare 'L Califano', Università degli Studi di Napoli 'Federico II', via S Pansini 5, 80131 Napoli, Italy.

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http://dx.doi.org/10.1038/sj.onc.1206475DOI Listing
May 2003

Tumor necrosis factor-related apoptosis-inducing ligand-induced death-inducing signaling complex and its modulation by c-FLIP and PED/PEA-15 in glioma cells.

J Biol Chem 2002 Jul 25;277(28):25020-5. Epub 2002 Apr 25.

Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M202946200
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July 2002

Glucose regulates insulin mitogenic effect by modulating SHP-2 activation and localization in JAr cells.

J Biol Chem 2002 Jul 30;277(27):24306-14. Epub 2002 Apr 30.

Dipartimento di Ginecologia, Ostetricia e Fisiopatologia della Riproduzione Umana, Università degli Studi di Napoli Federico II, 80131 Naples, Italy.

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http://dx.doi.org/10.1074/jbc.M202962200DOI Listing
July 2002

Multiple members of the mitogen-activated protein kinase family are necessary for PED/PEA-15 anti-apoptotic function.

J Biol Chem 2002 Mar 14;277(13):11013-8. Epub 2002 Jan 14.

Dipartimento di Biologia e Patologia Cellulare e Molecolare & Centro di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Università di Napoli Federico II, Via S. Pansini, 5, 80131 Naples, Italy.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M110934200
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http://dx.doi.org/10.1074/jbc.M110934200DOI Listing
March 2002