Francesco Albano, MD,PhD - Hematology - University of Bari - Assistant Professor

Francesco Albano

MD,PhD

Hematology - University of Bari

Assistant Professor

Bari | Italy

Main Specialties: Hematology

Additional Specialties: Hematology

Francesco Albano, MD,PhD - Hematology - University of Bari - Assistant Professor

Francesco Albano

MD,PhD

Introduction

Primary Affiliation: Hematology - University of Bari - Bari , Italy

Specialties:

Additional Specialties:

Publications

54Publications

642Reads

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128PubMed Central Citations

IgG-lymphoplasmacytic lymphoma following polycythemia vera: JAK2 V617F and MYD88 L265P mutations separated in the same house.

Ann Hematol 2014 Sep 10;93(9):1605-7. Epub 2014 Jan 10.

Department of Emergency and Organ Transplantation (D.E.T.O.), Hematology Section, University of Bari, P.zza G. Cesare, 70124, Bari, Italy.

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http://dx.doi.org/10.1007/s00277-013-2004-xDOI Listing
September 2014
27 Reads
2.634 Impact Factor

Acute myeloid leukemia with t(16;16) (p13;q22) showing a new CBFB-MYH11 fusion transcript associated with an atypical leukemic blasts morphology.

Hum Pathol 2014 Mar 3;45(3):643-7. Epub 2013 Oct 3.

Department of Emergency and Organ Transplantation (D.E.T.O.), Hematology Section, University of Bari, 70124 Bari, Italy.

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http://dx.doi.org/10.1016/j.humpath.2013.09.013DOI Listing
March 2014
5 Reads
2 Citations
2.770 Impact Factor

Immunophenotypic and molecular features of 'cuplike' acute myeloid leukemias.

Eur J Haematol 2014 Feb;92(2):121-6

Department of Emergency - Section of Haematology, University of Bari, Bari, Italy.

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http://dx.doi.org/10.1111/ejh.12217DOI Listing
February 2014
19 Reads
2.070 Impact Factor

A novel t(4;16)(q25;q23.1) associated with EGF and ELOVL6 deregulation in acute myeloid leukemia.

Gene 2013 Oct 9;529(1):144-7. Epub 2013 Aug 9.

Department of Emergency and Organ Transplantation (D.E.T.O.), Hematology Section, University of Bari, 70124 Bari, Italy.

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http://dx.doi.org/10.1016/j.gene.2013.07.105DOI Listing
October 2013
17 Reads
2 Citations
2.140 Impact Factor

Outcome of allogeneic peripheral blood stem cell transplantation by donor graft CD3+/Tregs ratio: a single-center experience.

Biol Blood Marrow Transplant 2013 Mar 27;19(3):495-9. Epub 2012 Nov 27.

Hematology Section, Department of Emergency and Organ Transplantation, University of Bari, Piazza Giulio Cesare 11,Bari, Italy.

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http://dx.doi.org/10.1016/j.bbmt.2012.11.015DOI Listing
March 2013
24 Reads
6 Citations
3.404 Impact Factor

Extramedullary disease in acute promyelocytic leukemia: two-in-one disease.

Mediterr J Hematol Infect Dis 2011 21;3(1):e2011066. Epub 2011 Dec 21.

Ematologia con Trapianto, Università degli Studi di Bari "Aldo Moro"

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http://dx.doi.org/10.4084/MJHID.2011.066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248343PMC
October 2012
2 Reads
4 Citations

A new recurrent chromosomal translocation t(3;11)(q13;q14) in myelodysplastic syndromes associated with overexpression of the ILDR1 gene.

Leuk Res 2012 Jul 25;36(7):852-6. Epub 2012 Feb 25.

Department of Emergency and Organ Transplantation, Hematology Section, University of Bari, 70124 Bari, Italy.

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http://dx.doi.org/10.1016/j.leukres.2012.01.026DOI Listing
July 2012
2 Reads
2 Citations
2.351 Impact Factor

Decreased TET2 gene expression during chronic myeloid leukemia progression.

Leukemia Research

Recently it has been demonstrated that ten-eleven-translocation-2 (TET2) gene alterations may represent a crucial event in the pathogenesis of various myeloid malignancies. To date, the loss of TET2 function has been solely ascribed to mutations in the gene coding region. In this study, we report a chronic myeloid leukemia (CML) case showing a TET2 single copy partial deletion associated to a t(4;6;11) rearrangement, appearing during the progression of the disease and responsible for a decreased TET2 gene expression. A putative role for TET2 haploinsufficiency in this patient's CML progression is discussed.

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November 2011
2 Reads

Genomic segmental duplications on the basis of the t(9;22) rearrangement in chronic myeloid leukemia

Oncogene. 2010 Apr 29;29(17):2509-16

Oncogene

A crucial role of segmental duplications (SDs) of the human genome has been shown in chromosomal rearrangements associated with several genomic disorders. Limited knowledge is yet available on the molecular processes resulting in chromosomal rearrangements in tumors. The t(9;22)(q34;q11) rearrangement causing the 5'BCR/3'ABL gene formation has been detected in more than 90% of cases with chronic myeloid leukemia (CML). In 10-18% of patients with CML, genomic deletions were detected on der(9) chromosome next to translocation breakpoints. The molecular mechanism triggering the t(9;22) and deletions on der(9) is still speculative. Here we report a molecular cytogenetic analysis of a large series of patients with CML with der(9) deletions, revealing an evident breakpoint clustering in two regions located proximally to ABL and distally to BCR, containing an interchromosomal duplication block (SD_9/22). The deletions breakpoints distribution appeared to be strictly related to the distance from the SD_9/22. Moreover, bioinformatic analyses of the regions surrounding the SD_9/22 revealed a high Alu frequency and a poor gene density, reflecting genomic instability and susceptibility to rearrangements. On the basis of our results, we propose a three-step model for t(9;22) formation consisting of alignment of chromosomes 9 and 22 mediated by SD_9/22, spontaneous chromosome breakages and misjoining of DNA broken ends.

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April 2010
3 Reads

MIRN199B downregulation in chronic myeloid leukaemia is associated with deletions on der(9).

Br J Haematol 2009 Jan 19;144(2):271-3. Epub 2008 Nov 19.

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http://dx.doi.org/10.1111/j.1365-2141.2008.07459.xDOI Listing
January 2009
3 Reads
1 Citation
4.711 Impact Factor

42. Subsets of CD34+ and early engraftment kinetics in allogeneic peripheral SCT for AML

Bone Marrow Transplant. 2008 Jun;41(11):977-81

Bone Marrow Transplantation

This study aimed to identify which graft product subset of CD34+ cells might be the most predictive of early hematopoietic recovery following allogeneic peripheral SCT (allo-PBSCT). The relationship between the number of 'mature' subsets of CD34+ cells (CD34+/CD33+, CD34+/CD38+, CD34+/DR+ and CD34+/CD133-) and 'immature' subsets of CD34+ cells (CD34+/CD33-, CD34+/CD38-, CD34+/DR- and CD34+/CD133+) and early neutrophil and platelet engraftment were studied in a homogeneous series (for disease, pre transplant chemotherapy, conditioning regimen and GVHD prophylaxis) of 30 AML patients after allo-PBSCT from HLA-identical siblings. In our experience, the total CD34+/CD133+ cell number was inversely correlated with the days required for the recovery of 0.5 x 10(9)/l neutrophils (r=or-0.82, P=0.02) and platelets of 20 x 10(9)/l (r=or-0.60, P=0.06); this correlation was better than the total CD34+ cell dose and neutrophil (r=or-0.70, P=0.04) and platelet engraftment (r=or-0.56, P=0.07). We suggest that a high number of CD34+/CD133+ PBSC may be associated with faster neutrophil and platelet recovery; these findings may help to predict the repopulating capacity of PBSC in patients after allo-PBSCT, especially when a relatively low number of CD34+ cells is infused.

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June 2008
4 Reads

Extramedullary molecular evidence of the 5'KIAA1509/3'PDGFRB fusion gene in chronic eosinophilic leukemia.

Leuk Res 2008 Feb 2;32(2):347-51. Epub 2007 Aug 2.

Hematology, University of Bari, Policlinico, Piazza G. Cesare 11, 70124 Bari, Italy.

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http://dx.doi.org/10.1016/j.leukres.2007.06.016DOI Listing
February 2008
14 Reads
2.351 Impact Factor

Late-appearing pseudocentric fission event during chronic myeloid leukemia progression.

Cancer Genet Cytogenet 2007 Apr;174(1):61-7

Department of Genetics and Microbiology, University of Bari, Via Amendola 165/A, 70126 Bari, Italy.

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http://dx.doi.org/10.1016/j.cancergencyto.2006.11.009DOI Listing
April 2007
17 Reads
2 Citations

Molecular cytogenetic characterization of deletions on der(9) in chronic myelocytic leukemia.

Cancer Genet Cytogenet 2006 Jun;167(2):97-102

Hematology, University of Foggia, Viale Pinto, 1, 71100, Foggia, Italy.

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http://dx.doi.org/10.1016/j.cancergencyto.2006.01.011DOI Listing
June 2006
15 Reads
4 Citations

57. Characterization of a recurrent translocation t(2;3)(p15-22;q26) occurring in acute myeloid leukaemia

Leukemia. 2006 Jan;20(1):48-54.

Leukemia

Six patients with de novo acute myeloid leukemia (AML) and a t(2;3)(p15-21;q26-27) were identified among approximately 1000 cases enrolled in the GIMEMA trial. The t(2;3) was the sole anomaly in three patients, whereas in three cases monosomy 7, trisomy 15 and 22, and trisomy 14 represented additional aberrations. No cryptic chromosome deletions at 5q, 7q, 12p, and 20q were observed. One patient carried a FLT3 D835 mutation; FLT3 internal tandem duplication (ITD) was not detected in three patients tested. Characterization of the translocation breakpoints using a 3q26 BAC contig specific for the PRDM3 locus showed that the breakpoints were located 5' to EVIl as follows: within myelodysplatic syndrome (MDS) intron 1 (# 3), between MDS1 exons 2 and 3 in three patients (# 1, 2, 4) with a 170bp cryptic deletion distal to the breakpoint in one (# 2), and in a more centromeric position spanning from intron 2 to the 5' region of EVI1 (# 6, 5). A set of 2p16-21 BAC probes showed that the breakpoints on chromosome 2p were located within BCL11A in two separate regions (# 1, 4 and # 2-5), within the thyroid adenoma-associated (THADA) gene (# 6) or distal to the ZFP36L2 locus (# 3). Regulatory elements were present in proximity of these breakpoints. RACE PCR studies revealed a chimeric transcript in 1/6 patient analyzed, but no fusion protein. Quantitative PCR showed a 21-58-fold over-expression of the EVIl gene in all cases analyzed. The patients showed dysplasia of at least two myeloid cell lineages in all cases; they had a low-to-normal platelet count and displayed an immature CD34+ CD117+ immunophenotype. Despite intensive chemotherapy and a median age of 43 years (range 36-59), only two patients attained a short-lived response; one patient is alive with active disease at 12 months, five died at 4-14 months. We arrived at the following conclusions: (a) the t(2;3) is a recurrent translocation having an approximate 0.5% incidence in adult AML; (b) breakpoints involve the 5' region of EVIl at 3q26, and the BCL11A, the THADA gene or other regions at 2p16.1-21; (c) cryptic deletions distal to the 3q26 breakpoint may occur in some cases; (d) the juxtaposition of the 5' region of EVIl with regulatory elements normally located on chromosome 2 brings about EVI1 overexpression; (e) clinical outcome in these cases is severe.

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January 2006
3 Reads

Submicroscopic deletions in an acute myeloid leukemia case with a four-way t(8;11;16;21).

Leuk Res 2005 Jul 2;29(7):855-8. Epub 2005 Mar 2.

Department of Hematology, University of Bari, Policlinico, Piazza G. Cesare 11, 70124 Bari, Italy.

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http://dx.doi.org/10.1016/j.leukres.2004.12.018DOI Listing
July 2005
8 Reads
2.351 Impact Factor

Non-treatment-related chronic myeloid leukemia as a second malignancy.

Leuk Res 2004 Feb;28(2):115-9

Department of Haematology, University of Bari, Policlinico, Piazza Giulio Cesare 11, 70124 Bari, Italy.

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http://dx.doi.org/10.1016/s0145-2126(03)00182-6DOI Listing
February 2004
5 Reads
1 Citation
2.351 Impact Factor

A chronic myelocytic leukemia case bearing deletions on the three chromosomes involved in a variant t(9;22;11).

Cancer Genet Cytogenet 2004 Jan;148(2):137-40

Sezione di Genetica, Dipartimento di Anatomia Patologica e Genetica, University of Bari, Bari, Italy.

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http://dx.doi.org/10.1016/s0165-4608(03)00246-2DOI Listing
January 2004
4 Reads
2 Citations

Genomic deletions on other chromosomes involved in variant t(9;22) chronic myeloid leukemia cases.

Genes Chromosomes Cancer 2003 Apr;36(4):353-60

Department of Hematology, University of Bari, 70126 Bari, Italy.

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http://doi.wiley.com/10.1002/gcc.10183
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http://dx.doi.org/10.1002/gcc.10183DOI Listing
April 2003
12 Reads
4 Citations
4.041 Impact Factor

Breakpoint characterization of der(9) deletions in chronic myeloid leukemia patients.

Genes Chromosomes Cancer 2002 Nov;35(3):271-6

Sezione di Genetica, DAPEG, University of Bari, Bari, Italy.

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http://dx.doi.org/10.1002/gcc.10116DOI Listing
November 2002
6 Reads
2 Citations
4.041 Impact Factor

Molecular cytogenetic characterization of a novel additional chromosomal aberration in blast crisis of a Ph-positive chronic myeloid leukemia.

Cancer Genet Cytogenet 2002 Apr;134(2):109-13

Department of Pathologic Anatomy and Genetics, Section of Genetics, University of Bari, Piazza G. Cesare 11, Via Amendola 165/A, 70126, Bari, Italy.

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http://dx.doi.org/10.1016/s0165-4608(01)00625-2DOI Listing
April 2002
3 Reads

Concomitant tetrasomy 3q and trisomy 18 in CD5(-), CD13(+) chronic lymphocytic leukemia.

Cancer Genet Cytogenet 2002 Mar;133(2):160-3

Department of Hematology, University of Bari, Policlinico, 70124 Bari, Italy.

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http://dx.doi.org/10.1016/s0165-4608(01)00583-0DOI Listing
March 2002
8 Reads
3 Citations

Top co-authors

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Luisa Anelli
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Antonella Zagaria
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Paola Casieri
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