Publications by authors named "Francesca M Buffa"

75Publications

MITF controls the TCA cycle to modulate the melanoma hypoxia response.

Pigment Cell Melanoma Res 2019 11 8;32(6):792-808. Epub 2019 Jul 8.

Ludwig Institute for Cancer Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1111/pcmr.12802DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6777998PMC
November 2019

Guidelines for using sigQC for systematic evaluation of gene signatures.

Nat Protoc 2019 05 10;14(5):1377-1400. Epub 2019 Apr 10.

Computational Biology and Integrative Genomics Lab, MRC/CRUK Oxford Institute and Department of Oncology, University of Oxford, Oxford, UK.

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http://www.nature.com/articles/s41596-019-0136-8
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http://dx.doi.org/10.1038/s41596-019-0136-8DOI Listing
May 2019

Modeling genotypes in their microenvironment to predict single- and multi-cellular behavior.

Gigascience 2019 03;8(3)

Computational Biology and Integrative Genomics, MRC/CRUK Oxford Institute, Departmemt of Oncology, University of Oxford, Old Road Campus, Oxford, Oxfordshire, OX3 7DQ, UK.

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http://dx.doi.org/10.1093/gigascience/giz010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423375PMC
March 2019

Pan-cancer characterisation of microRNA across cancer hallmarks reveals microRNA-mediated downregulation of tumour suppressors.

Nat Commun 2018 12 7;9(1):5228. Epub 2018 Dec 7.

Department of Oncology, Medical Sciences Division, University of Oxford, Oxford, OX3 7DQ, UK.

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http://dx.doi.org/10.1038/s41467-018-07657-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286392PMC
December 2018

The many faces of mathematical modelling in oncology.

Br J Radiol 2019 Jan 28;92(1093):20180856. Epub 2018 Nov 28.

CRUK/MRC Oxford Institute, Department of Oncology, Medical Science Division, University of Oxford , Oxford , United Kingdom.

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http://dx.doi.org/10.1259/bjr.20180856DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435080PMC
January 2019

Endogenous miRNA sponges mediate the generation of oscillatory dynamics for a non-coding RNA network.

J Theor Biol 2019 11 30;481:54-60. Epub 2018 Oct 30.

Departments of Translational Hematology and Oncology Research, Cleveland Clinic, Cleveland, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jtbi.2018.10.055DOI Listing
November 2019

Integrated Pharmacodynamic Analysis Identifies Two Metabolic Adaption Pathways to Metformin in Breast Cancer.

Cell Metab 2018 11 20;28(5):679-688.e4. Epub 2018 Sep 20.

Department of Oncology, University of Oxford, Churchill Hospital, Oxford OX3 7LE, UK; Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK; NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Churchill Hospital, Oxford OX3 7LE, UK.

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http://dx.doi.org/10.1016/j.cmet.2018.08.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224605PMC
November 2018

Development and Validation of a 28-gene Hypoxia-related Prognostic Signature for Localized Prostate Cancer.

EBioMedicine 2018 May 23;31:182-189. Epub 2018 Apr 23.

Translational Radiobiology Group, Division of Cancer Sciences, University of Manchester, Manchester Academic Health Science Centre, Christie Hospital, Manchester M20 4BX, UK; NIHR Manchester Biomedical Research Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2018.04.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6014579PMC
May 2018

IGF-1R associates with adverse outcomes after radical radiotherapy for prostate cancer.

Br J Cancer 2017 Nov 3;117(11):1600-1606. Epub 2017 Oct 3.

Department of Oncology, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK.

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http://dx.doi.org/10.1038/bjc.2017.337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5729437PMC
November 2017

Gemcitabine-Induced TIMP1 Attenuates Therapy Response and Promotes Tumor Growth and Liver Metastasis in Pancreatic Cancer.

Cancer Res 2017 11 1;77(21):5952-5962. Epub 2017 Aug 1.

Department of Oncology, CRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-2833DOI Listing
November 2017

TOPK modulates tumour-specific radiosensitivity and correlates with recurrence after prostate radiotherapy.

Br J Cancer 2017 Aug 4;117(4):503-512. Epub 2017 Jul 4.

CRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK.

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http://dx.doi.org/10.1038/bjc.2017.197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558685PMC
August 2017

In vitro downregulated hypoxia transcriptome is associated with poor prognosis in breast cancer.

Mol Cancer 2017 06 15;16(1):105. Epub 2017 Jun 15.

Department of Electronic and Computer Engineering, Brunel University London, Uxbridge, Middlesex, UB8 3PH, UK.

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http://dx.doi.org/10.1186/s12943-017-0673-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472949PMC
June 2017

Depletion of signal recognition particle 72kDa increases radiosensitivity.

Cancer Biol Ther 2017 06 11;18(6):425-432. Epub 2017 May 11.

a Cancer Research UK/ MRC Oxford Institute for Radiation Oncology, Gray Laboratories, Department of Oncology , University of Oxford , Oxford , UK.

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http://dx.doi.org/10.1080/15384047.2017.1323587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536942PMC
June 2017

A Gene Signature for Selecting Benefit from Hypoxia Modification of Radiotherapy for High-Risk Bladder Cancer Patients.

Clin Cancer Res 2017 Aug 11;23(16):4761-4768. Epub 2017 Apr 11.

Translational Radiobiology Group, Division of Cancer Sciences, University of Manchester, Manchester Academic Health Science Centre, Christie Hospital, Manchester, United Kingdom.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-0038DOI Listing
August 2017

Vitamin D Receptor Expression in Plasmablastic Lymphoma and Myeloma Cells Confers Susceptibility to Vitamin D.

Endocrinology 2017 03;158(3):503-515

Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford , Oxford , UK.

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http://dx.doi.org/10.1210/en.2016-1802DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460784PMC
March 2017

Genomic alterations underlie a pan-cancer metabolic shift associated with tumour hypoxia.

Genome Biol 2016 06 29;17(1):140. Epub 2016 Jun 29.

Computational Biology and Integrative Genomics, Department of Oncology, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1186/s13059-016-0999-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926297PMC
June 2016

FANCD2 limits replication stress and genome instability in cells lacking BRCA2.

Nat Struct Mol Biol 2016 08 20;23(8):755-757. Epub 2016 Jun 20.

The CR-UK/MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, U.K.

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http://dx.doi.org/10.1038/nsmb.3252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973888PMC
August 2016

Estrogen receptor-α directly regulates the hypoxia-inducible factor 1 pathway associated with antiestrogen response in breast cancer.

Proc Natl Acad Sci U S A 2015 Dec 23;112(49):15172-7. Epub 2015 Nov 23.

Growth Factor Group, Cancer Research UK, Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom;

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http://dx.doi.org/10.1073/pnas.1422015112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4679044PMC
December 2015

Combining lapatinib and pertuzumab to overcome lapatinib resistance due to NRG1-mediated signalling in HER2-amplified breast cancer.

Oncotarget 2015 Mar;6(8):5678-94

Department of Oncology, Molecular Oncology Laboratories, The Weatherall Institute of Molecular Medicine, University of Oxford, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467394PMC
http://dx.doi.org/10.18632/oncotarget.3296DOI Listing
March 2015

Glucose utilization via glycogen phosphorylase sustains proliferation and prevents premature senescence in cancer cells.

Cell Metab 2012 Dec 21;16(6):751-64. Epub 2012 Nov 21.

Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK.

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http://dx.doi.org/10.1016/j.cmet.2012.10.017DOI Listing
December 2012

Prospective technical validation and assessment of intra-tumour heterogeneity of a low density array hypoxia gene profile in head and neck squamous cell carcinoma.

Eur J Cancer 2013 Jan 27;49(1):156-65. Epub 2012 Aug 27.

Translational Radiobiology Group, Institute of Cancer Sciences, Manchester Academic Health Science Centre, Christie Hospital, Wilmslow Road, Manchester M20 4BX, United Kingdom.

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http://dx.doi.org/10.1016/j.ejca.2012.07.028DOI Listing
January 2013

Assessing early therapeutic response to bevacizumab in primary breast cancer using magnetic resonance imaging and gene expression profiles.

J Natl Cancer Inst Monogr 2011 ;2011(43):71-4

University Department of Oncology, Molecular Oncology Laboratories, Medical Oncology, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK.

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https://academic.oup.com/jncimono/article-lookup/doi/10.1093
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http://dx.doi.org/10.1093/jncimonographs/lgr027DOI Listing
March 2012

Gene expression and hypoxia in breast cancer.

Genome Med 2011 Aug 26;3(8):55. Epub 2011 Aug 26.

The Weatherall Institute of Molecular Medicine, Department of Oncology, University of Oxford, Oxford OX3 9DS, UK.

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http://dx.doi.org/10.1186/gm271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3238181PMC
August 2011

microRNA-associated progression pathways and potential therapeutic targets identified by integrated mRNA and microRNA expression profiling in breast cancer.

Cancer Res 2011 Sep 7;71(17):5635-45. Epub 2011 Jul 7.

Oncology Department, Weatherall Institute of Molecular Medicine, University of Oxford and Genomics Research, Wellcome Trust Centre for Human Genetics, Oxford, UK.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-11-0489DOI Listing
September 2011

Close and stable relationship between proliferation and a hypoxia metagene in aromatase inhibitor-treated ER-positive breast cancer.

Clin Cancer Res 2011 May 15;17(9):3005-12. Epub 2011 Feb 15.

Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, United Kingdom.

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http://dx.doi.org/10.1158/1078-0432.CCR-10-1704DOI Listing
May 2011

Overexpression of POLQ confers a poor prognosis in early breast cancer patients.

Oncotarget 2010 Jul;1(3):175-84

Gray Institute for Radiation Oncology and Biology, University of Oxford, Oxford, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2917771PMC
http://dx.doi.org/10.18632/oncotarget.124DOI Listing
July 2010

The histone demethylase JMJD2B is regulated by estrogen receptor alpha and hypoxia, and is a key mediator of estrogen induced growth.

Cancer Res 2010 Aug 3;70(16):6456-66. Epub 2010 Aug 3.

Growth Factor Group, Cancer Research UK, Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-0413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4261152PMC
August 2010

The role of hypoxia regulated microRNAs in cancer.

Curr Top Microbiol Immunol 2010 ;345:47-70

Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DS, UK.

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http://dx.doi.org/10.1007/82_2010_76DOI Listing
November 2010

hsa-mir-210 is a marker of tumor hypoxia and a prognostic factor in head and neck cancer.

Cancer 2010 May;116(9):2148-58

Cancer Research UK Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1002/cncr.25009DOI Listing
May 2010

Phase I/II trial of bevacizumab and radiotherapy for locally advanced inoperable colorectal cancer: vasculature-independent radiosensitizing effect of bevacizumab.

Clin Cancer Res 2009 Nov 3;15(22):7069-76. Epub 2009 Nov 3.

Departments of Pathology, and Radiotherapy/Oncology, Democritus University of Thrace, Alexandroupolis, Greece.

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http://dx.doi.org/10.1158/1078-0432.CCR-09-0688DOI Listing
November 2009

A new procedure for determining the genetic basis of a physiological process in a non-model species, illustrated by cold induced angiogenesis in the carp.

BMC Genomics 2009 Oct 23;10:490. Epub 2009 Oct 23.

Cancer Research UK Angiogenesis Group, Institute for Biomedical Research, Schools of Immunity and Infection and Cancer studies, College of Medicine and Dentistry, University of Birmingham, Birmingham, B15 2TT, UK.

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http://dx.doi.org/10.1186/1471-2164-10-490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771047PMC
October 2009

Assessment of tumour hypoxia for prediction of response to therapy and cancer prognosis.

J Cell Mol Med 2010 Jan 16;14(1-2):18-29. Epub 2009 Oct 16.

Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.

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http://doi.wiley.com/10.1111/j.1582-4934.2009.00944.x
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http://dx.doi.org/10.1111/j.1582-4934.2009.00944.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3837600PMC
January 2010

Multiple biomarker tissue microarrays: bioinformatics and practical approaches.

Cancer Metastasis Rev 2008 Sep;27(3):481-94

Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, K4/316 Clinical Science Center, 600 Highland Avenue, Madison, WI 53792, USA.

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http://link.springer.com/10.1007/s10555-008-9145-8
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http://dx.doi.org/10.1007/s10555-008-9145-8DOI Listing
September 2008

hsa-miR-210 Is induced by hypoxia and is an independent prognostic factor in breast cancer.

Clin Cancer Res 2008 Mar;14(5):1340-8

Genomics Group, Wellcome Trust Centre for Human Genetics, The Henry Wellcome Building for Genomic Medicine, University of Oxford, Oxford, United Kingdom.

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http://clincancerres.aacrjournals.org/content/14/5/1340.full
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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-07-1755DOI Listing
March 2008

A general framework for quantifying the effects of DNA repair inhibitors on radiation sensitivity as a function of dose.

Theor Biol Med Model 2007 Jul 19;4:25. Epub 2007 Jul 19.

Brighton and Sussex Medical School, University of Sussex, Falmer, Brighton, UK.

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http://dx.doi.org/10.1186/1742-4682-4-25DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1950494PMC
July 2007

Pre-treatment proliferation and the outcome of conventional and accelerated radiotherapy.

Eur J Cancer 2006 Feb 4;42(3):363-71. Epub 2006 Jan 4.

Gray Cancer Institute, Mount Vernon Hospital, Northwood, Middlesex HA6 2JR, UK.

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http://dx.doi.org/10.1016/j.ejca.2005.10.022DOI Listing
February 2006

Backscatter and dose perturbations for low- to medium-energy electron point sources at the interface between materials with different atomic numbers.

Radiat Res 2004 Dec;162(6):693-701

Gray Cancer Institute, Northwood, London, United Kingdom.

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http://dx.doi.org/10.1667/rr3271DOI Listing
December 2004

Molecular profiles as predictive marker for the effect of overall treatment time of radiotherapy in supraglottic larynx squamous cell carcinomas.

Radiother Oncol 2004 Sep;72(3):275-82

Department of Experimental Clinical Oncology, University Hospital of Aarhus, Noerrebrogade 44, build. 5, 8000 Aarhus C, Denmark.

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http://dx.doi.org/10.1016/j.radonc.2004.07.014DOI Listing
September 2004

A Monte-Carlo method for interface dosimetry of beta emitters.

Cancer Biother Radiopharm 2003 Jun;18(3):463-71

Joint Department of Physics, Institute of Cancer Research, University of London, UK.

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http://dx.doi.org/10.1089/108497803322285224DOI Listing
June 2003