Francesca Lovat

Francesca Lovat

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Francesca Lovat

Francesca Lovat

Publications by authors named "Francesca Lovat"

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42Publications

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WWOX and p53 Dysregulation Synergize to Drive the Development of Osteosarcoma.

Cancer Res 2016 10 22;76(20):6107-6117. Epub 2016 Aug 22.

The Lautenberg Center for Immunology and Cancer Research, IMRIC, Faculty of Medicine, Hebrew University of Jerusalem, Israel. Department of Cancer Biology and Genetics (CBG), The Ohio State University Wexner Medical Center, Columbus, Ohio. Department of Biochemistry, University of Vermont College of Medicine, Burlington, Vermont.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-0621DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5146760PMC
October 2016

Lung cancer exosomes as drivers of epithelial mesenchymal transition.

Oncotarget 2016 Aug;7(34):54852-54866

Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, The Ohio State University, Columbus, Ohio 43210, USA.

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http://dx.doi.org/10.18632/oncotarget.10243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342386PMC
August 2016

microRNA classifiers are powerful diagnostic/prognostic tools in ALK-, EGFR-, and KRAS-driven lung cancers.

Proc Natl Acad Sci U S A 2015 Dec 16;112(48):14924-9. Epub 2015 Nov 16.

Comprehensive Cancer Center, Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, OH 43210;

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http://dx.doi.org/10.1073/pnas.1520329112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4672770PMC
December 2015

miR-15b/16-2 deletion promotes B-cell malignancies.

Proc Natl Acad Sci U S A 2015 Sep 31;112(37):11636-41. Epub 2015 Aug 31.

Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, OH 43210;

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http://dx.doi.org/10.1073/pnas.1514954112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4577143PMC
September 2015

Generation of mouse lines conditionally over-expressing microRNA using the Rosa26-Lox-Stop-Lox system.

Methods Mol Biol 2014 ;1194:203-24

Department of Molecular Virology, Immunology and Medical Genetics, Wexner Medical Center, Comprehensive Cancer Center, The Ohio State University, Biomedical Research Tower, Room 988, 460W. 12th Avenue, Columbus, OH, 43210, USA.

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http://dx.doi.org/10.1007/978-1-4939-1215-5_11DOI Listing
March 2015

Androgen receptor status is a prognostic marker in non-basal triple negative breast cancers and determines novel therapeutic options.

PLoS One 2014 5;9(2):e88525. Epub 2014 Feb 5.

Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University Wexner Medical Center and Comprehensive Cancer Center, Columbus, Ohio, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0088525PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914993PMC
September 2014

miR-15b/16-2 regulates factors that promote p53 phosphorylation and augments the DNA damage response following radiation in the lung.

J Biol Chem 2014 Sep 4;289(38):26406-16. Epub 2014 Aug 4.

From the Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, James Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210

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http://dx.doi.org/10.1074/jbc.M114.573592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176210PMC
September 2014

Fhit delocalizes annexin a4 from plasma membrane to cytosol and sensitizes lung cancer cells to paclitaxel.

PLoS One 2013 6;8(11):e78610. Epub 2013 Nov 6.

Department of Molecular Immunology, Virology and Medical Genetics, The Ohio State University, Columbus, Ohio, United States of America ; Lymphoma and Genomics Research Program, IOR Institute of Oncology Research, Bellinzona, Switzerland ; Dipartimento di Medicina Sperimentale e Clinica, University Magna Græcia, Campus "S. Venuta", Catanzaro, Italy.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0078610PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3819369PMC
August 2014

Protective role of miR-155 in breast cancer through RAD51 targeting impairs homologous recombination after irradiation.

Proc Natl Acad Sci U S A 2014 Mar 10;111(12):4536-41. Epub 2014 Mar 10.

Department of Molecular Virology, Immunology and Medical Genetics, Wexner Medical Center and Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210.

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http://dx.doi.org/10.1073/pnas.1402604111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970505PMC
March 2014

LZTS1 downregulation confers paclitaxel resistance and is associated with worse prognosis in breast cancer.

Oncotarget 2014 Feb;5(4):970-7

Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University Wexner Medical Center and Comprehensive Cancer Center, Columbus, Ohio, USA.

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http://www.oncotarget.com/fulltext/1630
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011598PMC
http://dx.doi.org/10.18632/oncotarget.1630DOI Listing
February 2014

B-cell malignancies in microRNA Eμ-miR-17~92 transgenic mice.

Proc Natl Acad Sci U S A 2013 Nov 21;110(45):18208-13. Epub 2013 Oct 21.

Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University Wexner Medical Center, Columbus, OH 43210.

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http://dx.doi.org/10.1073/pnas.1315365110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3831438PMC
November 2013

Angiotensin-converting-enzyme inhibition counteracts angiotensin II-mediated endothelial cell dysfunction by modulating the p38/SirT1 axis.

J Hypertens 2013 Oct;31(10):1972-83

aDepartment of Applied Clinical Sciences and Biotechnology, University of L'Aquila bDepartment MeSVA, University of L'Aquila, L'Aquila, Italy cDepartment of Molecular Immunology, Virology, and Medical Genetics, The Ohio State University, Columbus, Ohio, USA dPreclinical Development Department, Menarini Ricerche, Firenze, Italy *Francesco Marampon and Giovanni L. Gravina contributed equally to the writing of this article.

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http://dx.doi.org/10.1097/HJH.0b013e3283638b32DOI Listing
October 2013

Integrated microRNA and mRNA signatures associated with survival in triple negative breast cancer.

PLoS One 2013 6;8(2):e55910. Epub 2013 Feb 6.

Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University Wexner Medical Center, Columbus, Ohio, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0055910PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566108PMC
August 2013

Non-coding RNAs and cancer.

Int J Mol Sci 2013 Aug 19;14(8):17085-110. Epub 2013 Aug 19.

Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.3390/ijms140817085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759953PMC
August 2013

Toll-like receptor 3 (TLR3) activation induces microRNA-dependent reexpression of functional RARβ and tumor regression.

Proc Natl Acad Sci U S A 2013 Jun 28;110(24):9812-7. Epub 2013 May 28.

Department of Anatomical, Histological, Forensic & Orthopaedic Sciences, DAHFMO, Unit of Histology and Medical Embryology, Istituto Pasteur-Fondazione Cenci Bolognetti, La Sapienza University of Rome, 00161 Rome, Italy.

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http://dx.doi.org/10.1073/pnas.1304610110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683754PMC
June 2013

miRNA signatures associate with pathogenesis and progression of osteosarcoma.

Cancer Res 2012 Apr 20;72(7):1865-77. Epub 2012 Feb 20.

Department of Orthopaedics and Center for Children's Cancer Research, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-11-2663DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328547PMC
April 2012

MicroRNAs in the pathogenesis of cancer.

Semin Oncol 2011 Dec;38(6):724-33

Molecular Virology Immunology & Medical Genetics, The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S009377541100214
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http://dx.doi.org/10.1053/j.seminoncol.2011.08.006DOI Listing
December 2011

Mutated beta-catenin evades a microRNA-dependent regulatory loop.

Proc Natl Acad Sci U S A 2011 Mar 7;108(12):4840-5. Epub 2011 Mar 7.

Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1073/pnas.1101734108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3064338PMC
March 2011

Role of T198 modification in the regulation of p27(Kip1) protein stability and function.

PLoS One 2011 Mar 14;6(3):e17673. Epub 2011 Mar 14.

Division of Experimental Oncology 2, Centro di Riferimento Oncologico, National Cancer Institute, Aviano, Italy.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0017673PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3056717PMC
March 2011

MicroRNA-21 induces resistance to 5-fluorouracil by down-regulating human DNA MutS homolog 2 (hMSH2).

Proc Natl Acad Sci U S A 2010 Dec 15;107(49):21098-103. Epub 2010 Nov 15.

Departments of Molecular Virology, Ohio State University Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1015541107
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http://dx.doi.org/10.1073/pnas.1015541107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3000294PMC
December 2010

Proepithelin is an autocrine growth factor for bladder cancer.

Carcinogenesis 2009 May 23;30(5):861-8. Epub 2009 Feb 23.

Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1093/carcin/bgp050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2675649PMC
May 2009

Stathmin activity influences sarcoma cell shape, motility, and metastatic potential.

Mol Biol Cell 2008 May 27;19(5):2003-13. Epub 2008 Feb 27.

Division of Experimental Oncology 2, Division of Pathology, and Clinical and Experimental Hematology Research Unit, Centro di Riferimento Oncologico, Istituto Nazionale Tumori, IRCCS Aviano 33081, Italy.

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http://dx.doi.org/10.1091/mbc.e07-09-0894DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2366875PMC
May 2008

p27Kip1 expression inhibits glioblastoma growth, invasion, and tumor-induced neoangiogenesis.

Mol Cancer Ther 2008 May;7(5):1164-75

Division of Experimental Oncology 2, Centro di Riferimento Oncologico, Istituto Nazionale Tumori, IRCCS, Via Franco Gallini, 2 33081 Aviano, Italy.

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http://dx.doi.org/10.1158/1535-7163.MCT-07-2154DOI Listing
May 2008