Frances Shepherd

Frances Shepherd

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Frances Shepherd

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Evolution of rotavirus C in humans and several domestic animal species.

Zoonoses Public Health 2019 08 7;66(5):546-557. Epub 2019 Mar 7.

Veterinary Diagnostic Laboratory, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas.

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http://dx.doi.org/10.1111/zph.12575DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6629501PMC
August 2019

Financial Burden Among Patients With Lung Cancer in a Publically Funded Health Care System.

Clin Lung Cancer 2019 07 22;20(4):231-236. Epub 2018 Dec 22.

Princess Margaret Cancer Centre/University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.cllc.2018.12.010DOI Listing
July 2019

Outcomes of Long-term Interval Rescreening With Low-Dose Computed Tomography for Lung Cancer in Different Risk Cohorts.

J Thorac Oncol 2019 Jun 13;14(6):1003-1011. Epub 2019 Feb 13.

Department of Cardiothoracic Imaging, Toronto Joint Department of Medical Imaging, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.jtho.2019.01.031DOI Listing
June 2019

Elevated Platelet Count Appears to Be Causally Associated with Increased Risk of Lung Cancer: A Mendelian Randomization Analysis.

Cancer Epidemiol Biomarkers Prev 2019 May 30;28(5):935-942. Epub 2019 Jan 30.

Department of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China.

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http://dx.doi.org/10.1158/1055-9965.EPI-18-0356DOI Listing
May 2019

Effect of Coexisting KRAS and TP53 Mutations in Patients Treated With Chemotherapy for Non-small-cell Lung Cancer.

Clin Lung Cancer 2019 05 19;20(3):e338-e345. Epub 2018 Dec 19.

Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network and Department of Medicine, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1016/j.cllc.2018.12.009DOI Listing
May 2019

Genetic interaction analysis among oncogenesis-related genes revealed novel genes and networks in lung cancer development.

Oncotarget 2019 Mar 5;10(19):1760-1774. Epub 2019 Mar 5.

Biomedical Data Science Department, Dartmouth College, Hanover, NH, USA.

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http://dx.doi.org/10.18632/oncotarget.26678DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442994PMC
March 2019

A Career in Lung Cancer: Pushing Beyond Chemotherapy.

Am Soc Clin Oncol Educ Book 2019 Jan 17;39:583-589. Epub 2019 May 17.

3 The University of Texas Southwestern School of Medicine, Dallas, TX.

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http://dx.doi.org/10.1200/EDBK_239397DOI Listing
January 2019

Targeting the CDK4/6-Rb Pathway Enhances Response to PI3K Inhibition in -Mutant Lung Squamous Cell Carcinoma.

Clin Cancer Res 2018 12 9;24(23):5990-6000. Epub 2018 Aug 9.

University Health Network, Ontario Cancer Institute/Princess Margaret Cancer Centre, Toronto, Ontario, Canada.

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http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
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http://dx.doi.org/10.1158/1078-0432.CCR-18-0717DOI Listing
December 2018

Importance of Long-term Low-Dose CT Follow-up after Negative Findings at Previous Lung Cancer Screening.

Radiology 2018 10 10;289(1):218-224. Epub 2018 Jul 10.

From the Department of Cardiothoracic Imaging, Toronto Joint Department of Medical Imaging, University Health Network, Toronto, Canada (J.K., H.S.); Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, Toronto, Canada (G.L., G.M.O., M.M., F.A.S.); Toronto Joint Department of Medical Imaging Research, University Health Network, Toronto, Canada (R.M.); and Department of Pathology, Toronto General Hospital, Toronto, Canada (M.T.).

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http://pubs.rsna.org/doi/10.1148/radiol.2018180053
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http://dx.doi.org/10.1148/radiol.2018180053DOI Listing
October 2018

Tumor Mutation Burden as a Biomarker in Resected Non-Small-Cell Lung Cancer.

J Clin Oncol 2018 10 14;36(30):2995-3006. Epub 2018 Aug 14.

Siddhartha Devarakonda, Irena Lanc, and Ramaswamy Govindan, Washington University School of Medicine; Siddhartha Devarakonda and Ramaswamy Govindan, Siteman Cancer Center; Robert Fulton, Washington University School of Medicine, St. Louis; Ashiq Masood, University of Missouri Kansas City, Kansas City, MO; Federico Rotolo, Ken A. Olaussen, Gwénaël Le Teuff, Jean-Pierre Pignon, and Stefan Michiels, Université Paris-Saclay; Federico Rotolo, Ken A. Olaussen, Gwénaël Le Teuff, Jean-Pierre Pignon, Jean-Charles Soria, and Stefan Michiels, Gustave Roussy Cancer Campus, Villejuif; Elisabeth Brambilla and Anne McLeer-Florin, Centre Hospitalier Universitaire de Grenoble, La Tronche, France; Ming-Sound Tsao, Shingo Sakashita, and Frances A. Shepherd, Princess Margaret Cancer Centre and University of Toronto, Toronto; Keyue Ding and Lesley Seymour, Queen's University Kingston, Ontario, Canada; Stephen L. Graziano, State University of New York Upstate Medical University, Syracuse, NY; Robert Kratzke, University of Minnesota Medical School, Minneapolis, MN.

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http://dx.doi.org/10.1200/JCO.2018.78.1963DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804865PMC
October 2018

The prognostic effect of single and multiple cancer-related somatic mutations in resected non-small-cell lung cancer.

Lung Cancer 2018 09 19;123:22-29. Epub 2018 Jun 19.

Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network and the University of Toronto, Toronto, Ontario, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S01695002183043
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http://dx.doi.org/10.1016/j.lungcan.2018.06.023DOI Listing
September 2018

Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk.

Authors:
Xuemei Ji Yohan Bossé Maria Teresa Landi Jiang Gui Xiangjun Xiao David Qian Philippe Joubert Maxime Lamontagne Yafang Li Ivan Gorlov Mariella de Biasi Younghun Han Olga Gorlova Rayjean J Hung Xifeng Wu James McKay Xuchen Zong Robert Carreras-Torres David C Christiani Neil Caporaso Mattias Johansson Geoffrey Liu Stig E Bojesen Loic Le Marchand Demetrios Albanes Heike Bickeböller Melinda C Aldrich William S Bush Adonina Tardon Gad Rennert Chu Chen M Dawn Teare John K Field Lambertus A Kiemeney Philip Lazarus Aage Haugen Stephen Lam Matthew B Schabath Angeline S Andrew Hongbing Shen Yun-Chul Hong Jian-Min Yuan Pier A Bertazzi Angela C Pesatori Yuanqing Ye Nancy Diao Li Su Ruyang Zhang Yonathan Brhane Natasha Leighl Jakob S Johansen Anders Mellemgaard Walid Saliba Christopher Haiman Lynne Wilkens Ana Fernandez-Somoano Guillermo Fernandez-Tardon Erik H F M van der Heijden Jin Hee Kim Juncheng Dai Zhibin Hu Michael P A Davies Michael W Marcus Hans Brunnström Jonas Manjer Olle Melander David C Muller Kim Overvad Antonia Trichopoulou Rosario Tumino Jennifer Doherty Gary E Goodman Angela Cox Fiona Taylor Penella Woll Irene Brüske Judith Manz Thomas Muley Angela Risch Albert Rosenberger Kjell Grankvist Mikael Johansson Frances Shepherd Ming-Sound Tsao Susanne M Arnold Eric B Haura Ciprian Bolca Ivana Holcatova Vladimir Janout Milica Kontic Jolanta Lissowska Anush Mukeria Simona Ognjanovic Tadeusz M Orlowski Ghislaine Scelo Beata Swiatkowska David Zaridze Per Bakke Vidar Skaug Shanbeh Zienolddiny Eric J Duell Lesley M Butler Woon-Puay Koh Yu-Tang Gao Richard Houlston John McLaughlin Victoria Stevens David C Nickle Ma'en Obeidat Wim Timens Bin Zhu Lei Song María Soler Artigas Martin D Tobin Louise V Wain Fangyi Gu Jinyoung Byun Ahsan Kamal Dakai Zhu Rachel F Tyndale Wei-Qi Wei Stephen Chanock Paul Brennan Christopher I Amos

Nat Commun 2018 08 13;9(1):3221. Epub 2018 Aug 13.

Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, 03750, NH, USA.

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http://dx.doi.org/10.1038/s41467-018-05074-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089967PMC
August 2018

Venous thromboembolism with EGFR monoclonal antibody necitumumab in stage IV non-small cell lung cancer: A retrospective cohort analysis.

Thromb Res 2018 07 7;167:50-56. Epub 2018 May 7.

Princess Margaret Cancer Centre, University of Toronto, 610 University Avenue Toronto, Ontario, M5G2M9, Canada.

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http://dx.doi.org/10.1016/j.thromres.2018.05.004DOI Listing
July 2018

Helicase-like transcription factor expression is associated with a poor prognosis in Non-Small-Cell Lung Cancer (NSCLC).

BMC Cancer 2018 04 16;18(1):429. Epub 2018 Apr 16.

Department of Muldisciplinary Oncology and Therapeutic Innovations, Assistance Publique des Hôpitaux de Marseille (AP-HM), Aix-Marseille University, Chemin des Bourrely, 13195, Marseille, Cedex 20, France.

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http://dx.doi.org/10.1186/s12885-018-4215-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902896PMC
April 2018

Whole Genome Classification and Phylogenetic Analyses of Rotavirus B strains from the United States.

Pathogens 2018 Apr 18;7(2). Epub 2018 Apr 18.

Veterinary Diagnostic Laboratory, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA.

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http://dx.doi.org/10.3390/pathogens7020044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027208PMC
April 2018

Genome-wide interaction study of smoking behavior and non-small cell lung cancer risk in Caucasian population.

Carcinogenesis 2018 03;39(3):336-346

Biomedical Data Science Department, Dartmouth College, Hanover, NH, USA.

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http://dx.doi.org/10.1093/carcin/bgx113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6248554PMC
March 2018

Do Correlates of Pain-Related Stoicism and Cautiousness Differ in Younger and Older People With Advanced Cancer?

J Pain 2018 03 16;19(3):301-316. Epub 2017 Nov 16.

Department of Anesthesia and Pain Management, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada; Department of Supportive Care, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada; School of Kinesiology and Health Science, Faculty of Health, York University, Toronto, Ontario, Canada; Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Department of Anesthesia, Mount Sinai Hospital, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jpain.2017.11.002DOI Listing
March 2018

Longitudinal Surveillance of Porcine Rotavirus B Strains from the United States and Canada and Identification of Antigenically Important Sites.

Pathogens 2017 Dec 3;6(4). Epub 2017 Dec 3.

Veterinary Diagnostic Laboratory, Kansas State University, 1800 Denison Ave, Manhattan, KS 66506, USA.

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http://dx.doi.org/10.3390/pathogens6040064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5750588PMC
December 2017

Adjuvant Systemic Therapy and Adjuvant Radiation Therapy for Stage I to IIIA Completely Resected Non-Small-Cell Lung Cancers: American Society of Clinical Oncology/Cancer Care Ontario Clinical Practice Guideline Update.

J Clin Oncol 2017 Sep 24;35(25):2960-2974. Epub 2017 Apr 24.

Mark G. Kris and Jamie E. Chaft, Memorial Sloan Kettering Cancer Center; Harvey I. Pass, New York University Langone Medical Center, New York; Rahul Seth, Upstate Medical Center, Syracuse University, Syracuse, NY; Laurie E. Gaspar and Michael Weyant, University of Colorado School of Medicine, Aurora, CO; Erin B. Kennedy, American Society of Clinical Oncology, Alexandria, VA; Christopher G. Azzoli, Massachusetts General Hospital, Boston, MA; Steven H. Lin, MD Anderson Cancer Center; John R. Strawn, Patient Representative, Houston, TX; David R. Spigel, Sarah Cannon Cancer Center, Nashville, TN; Peter M. Ellis, Juravinski Cancer Center, Hamilton Health Sciences, Hamilton; Frances A. Shepherd, Princess Margaret Cancer Centre, University Health Network; and Yee C. Ung, Sunnybrook Regional Cancer Center, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1200/JCO.2017.72.4401DOI Listing
September 2017

Clinical Predictors of Early Mortality in Colorectal Cancer Patients Undergoing Chemotherapy: Results From a Global Prospective Cohort Study.

JNCI Cancer Spectr 2017 Sep 28;1(1):pkx009. Epub 2017 Nov 28.

Hematology/Oncology, Cleveland Clinic, Cleveland, OH (DPSS, MFK, KM, AAK); Hematology/Oncology, University of Washington, Seattle, WA (NMK, GHL); Princess Margaret Cancer Centre, University of Toronto, Toronto, Canada (FAS); Haematology and Haemostaseology, Medical University of Vienna, Vienna, Austria (IP); Stroke Unit, Internal and Cardiovascular Medicine, University of Perugia, Perugia, Italy (GA); Jane Anne Nohl Devision of Hematology, University of Southern California, Los Angeles, CA (HAL); Respiratory and Intensive Care Medicine, Universite Paris Descartes, Paris, France (GM).

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http://dx.doi.org/10.1093/jncics/pkx009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6649852PMC
September 2017

Phase II Trial of Atezolizumab As First-Line or Subsequent Therapy for Patients With Programmed Death-Ligand 1-Selected Advanced Non-Small-Cell Lung Cancer (BIRCH).

J Clin Oncol 2017 Aug 13;35(24):2781-2789. Epub 2017 Jun 13.

Solange Peters, Centre Hospitalier Universitaire Vaudois, Lausanne; Martin Früh, Kantonsspital St Gallen, St Gallen, Switzerland; Scott Gettinger, Yale Cancer Center, New Haven, CT; Melissa L. Johnson, Sarah Cannon Research Institute, Nashville, TN; Pasi A. Jänne, Dana-Farber Cancer Institute, Boston, MA; Marina C. Garassino, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy; Daniel Christoph, Universitätsklinikum Essen, and the Ruhrlandklinik, Universität Duisburg-Essen, Essen; Martin Reck, Lung Clinic Grosshansdorf, Airway Research Center North (ARCN), Member of the German Center for Lung Research (DZL), Grosshansdorf, Germany; Chee Keong Toh, National Cancer Centre, Singapore, Singapore; Naiyer A. Rizvi and Jamie E. Chaft, Memorial Sloan Kettering Cancer Center; Jamie E. Chaft, Weill Cornell Medical College, New York, NY; Enric Carcereny Costa, Catalan Institute of Oncology Badalona, Badalona; Luis Paz-Ares, Hospital Universitario Doce de Octubre & IIS i+12, CNIO, Ciberonc and Universidad Complutense, Madrid; Enriqueta Felip, Vall d'Hebron University Hospital and Vall d'Hebron Institute of Oncology, Barcelona, Spain; Jyoti D. Patel, University of Chicago, Chicago, IL; Laura Q.M. Chow, University of Washington, Seattle, WA; Marianna Koczywas, City of Hope, Duarte; Zhengrong Li, Jiaheng Qiu, Marcin Kowanetz, Simonetta Mocci, Geetha Shankar, and Alan Sandler, Genentech, South San Francisco, CA; Cheryl Ho, Vancouver Centre, BC Cancer Agency, Vancouver, British Columbia; Jeffrey Rothenstein, R.S. McLaughlin Durham Regional Cancer Centre, Oshawa; Frances A. Shepherd, Princess Margaret Cancer Centre/University Health Network and University of Toronto, Toronto, Ontario, Canada; Michel van den Heuvel, The Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Amsterdam, Netherlands; and Takayasu Kurata, Kansai Medical University Hirakata Hospital, Osaka, Japan.

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http://dx.doi.org/10.1200/JCO.2016.71.9476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5562171PMC
August 2017

Psychometric Evaluation of the Pain Attitudes Questionnaire-Revised for People With Advanced Cancer.

J Pain 2017 07 6;18(7):811-824. Epub 2017 Mar 6.

Department of Supportive Care, Princess Margaret Cancer Centre, Toronto, Ontario, Canada; Department of Anesthesia and Pain Management, Toronto General Hospital, Toronto, Ontario, Canada; School of Kinesiology and Health Science, Faculty of Health, York University, Toronto, Ontario, Canada; Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Department of Anesthesia, Mount Sinai Hospital, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jpain.2017.02.432DOI Listing
July 2017

Uncommon EGFR mutations in advanced non-small cell lung cancer.

Lung Cancer 2017 07 27;109:137-144. Epub 2017 Apr 27.

Princess Margaret Cancer Centre, 610 University Avenue, Toronto, ON M5G 2M9, Canada.

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http://dx.doi.org/10.1016/j.lungcan.2017.04.016DOI Listing
July 2017

Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes.

Authors:
James D McKay Rayjean J Hung Younghun Han Xuchen Zong Robert Carreras-Torres David C Christiani Neil E Caporaso Mattias Johansson Xiangjun Xiao Yafang Li Jinyoung Byun Alison Dunning Karen A Pooley David C Qian Xuemei Ji Geoffrey Liu Maria N Timofeeva Stig E Bojesen Xifeng Wu Loic Le Marchand Demetrios Albanes Heike Bickeböller Melinda C Aldrich William S Bush Adonina Tardon Gad Rennert M Dawn Teare John K Field Lambertus A Kiemeney Philip Lazarus Aage Haugen Stephen Lam Matthew B Schabath Angeline S Andrew Hongbing Shen Yun-Chul Hong Jian-Min Yuan Pier Alberto Bertazzi Angela C Pesatori Yuanqing Ye Nancy Diao Li Su Ruyang Zhang Yonathan Brhane Natasha Leighl Jakob S Johansen Anders Mellemgaard Walid Saliba Christopher A Haiman Lynne R Wilkens Ana Fernandez-Somoano Guillermo Fernandez-Tardon Henricus F M van der Heijden Jin Hee Kim Juncheng Dai Zhibin Hu Michael P A Davies Michael W Marcus Hans Brunnström Jonas Manjer Olle Melander David C Muller Kim Overvad Antonia Trichopoulou Rosario Tumino Jennifer A Doherty Matt P Barnett Chu Chen Gary E Goodman Angela Cox Fiona Taylor Penella Woll Irene Brüske H-Erich Wichmann Judith Manz Thomas R Muley Angela Risch Albert Rosenberger Kjell Grankvist Mikael Johansson Frances A Shepherd Ming-Sound Tsao Susanne M Arnold Eric B Haura Ciprian Bolca Ivana Holcatova Vladimir Janout Milica Kontic Jolanta Lissowska Anush Mukeria Simona Ognjanovic Tadeusz M Orlowski Ghislaine Scelo Beata Swiatkowska David Zaridze Per Bakke Vidar Skaug Shanbeh Zienolddiny Eric J Duell Lesley M Butler Woon-Puay Koh Yu-Tang Gao Richard S Houlston John McLaughlin Victoria L Stevens Philippe Joubert Maxime Lamontagne David C Nickle Ma'en Obeidat Wim Timens Bin Zhu Lei Song Linda Kachuri María Soler Artigas Martin D Tobin Louise V Wain Thorunn Rafnar Thorgeir E Thorgeirsson Gunnar W Reginsson Kari Stefansson Dana B Hancock Laura J Bierut Margaret R Spitz Nathan C Gaddis Sharon M Lutz Fangyi Gu Eric O Johnson Ahsan Kamal Claudio Pikielny Dakai Zhu Sara Lindströem Xia Jiang Rachel F Tyndale Georgia Chenevix-Trench Jonathan Beesley Yohan Bossé Stephen Chanock Paul Brennan Maria Teresa Landi Christopher I Amos

Nat Genet 2017 Jul 12;49(7):1126-1132. Epub 2017 Jun 12.

Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.

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http://dx.doi.org/10.1038/ng.3892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510465PMC
July 2017

Pooled Analysis of the Prognostic and Predictive Effects of TP53 Comutation Status Combined With KRAS or EGFR Mutation in Early-Stage Resected Non-Small-Cell Lung Cancer in Four Trials of Adjuvant Chemotherapy.

J Clin Oncol 2017 Jun 28;35(18):2018-2027. Epub 2017 Apr 28.

Frances A. Shepherd and Ming-Sound Tsao, Princess Margaret Cancer Centre; University of Toronto, Toronto; Lesley Seymour, Queen's University, Kingston, Ontario, Canada; Benjamin Lacas, Gwénaël Le Teuff, Jean-Pierre Pignon, Thierry Le Chevalier, and Jean-Charles Soria, Institut Gustave-Roussy; Benjamin Lacas, Gwénaël Le Teuff, Jean-Pierre Pignon, Thierry Le Chevalier, and Jean-Charles Soria, University Paris XI, Paris; Pierre Hainaut, International Agency for Research on Cancer, Lyon; Jean-Yves Douillard, R Gauducheau, St Herblain; Elizabeth Brambilla, Inserm U823, Institut Albert Bonniot, Département de Pathologie CHU, Albert Michallon University Joseph Fourrier, Grenoble, France; Pasi A. Jänne, Dana-Farber Cancer Institute, Boston, MA; Stephen Graziano, State University of New York Upstate Medical University, Syracuse, NY; Robert Kratzke, University of Minnesota Medical School, Minneapolis, MN; and Robert Pirker and Martin Filipits, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1200/JCO.2016.71.2893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075828PMC
June 2017

Evolution of Symptom Burden of Advanced Lung Cancer Over a Decade.

Clin Lung Cancer 2017 05 5;18(3):274-280.e6. Epub 2017 Jan 5.

Princess Margaret Cancer Centre, University Health Network, Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cllc.2016.12.010DOI Listing
May 2017

Osimertinib or Platinum-Pemetrexed in EGFR T790M-Positive Lung Cancer.

N Engl J Med 2017 02 6;376(7):629-640. Epub 2016 Dec 6.

From the State Key Laboratory in Oncology in South China, Sir Y.K. Pao Centre for Cancer, Department of Clinical Oncology, Chinese University of Hong Kong, Hong Kong (T.S.M.), the Division of Pulmonary Oncology, Guangdong Lung Cancer Institute, Guangdong General Hospital, and Guangdong Academy of Medical Sciences, Guangzhou (Y.-L.W.), and the Department of Respiratory Disease, Daping Hospital, Third Military Medical University, Chongqing (Y.H.) - all in China; the Department of Medicine, Division of Hematology-Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, (M.-J.A.), and the Yonsei Cancer Center, Department of Internal Medicine, Division of Medical Oncology, Yonsei University College of Medicine (H.R.K.), Seoul, South Korea; the Thoracic Oncology Unit, Medical Oncology Department, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Nazionale dei Tumori, Milan (M.C.G.); the Department of Hematology and Medical Oncology, Emory University School of Medicine, Winship Cancer Institute, Atlanta (S.S.R.); the Department of Medical Oncology and Haematology, Princess Margaret Cancer Centre, Toronto (F.A.S.); the Third Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan (H.A.); the Department of Thoracic Oncology, the Netherlands Cancer Institute, Plesmanlaan, Amsterdam (W.S.M.E.T.); the Clinical Research Unit, Division of Cancer Services, St. George Hospital, Kogarah, NSW, Australia (C.K.L.); the Department of Hematology-Oncology, Johann Wolfgang Goethe University Medical Center, Frankfurt am Main, Germany (M.S.); AstraZeneca, Cambridge, United Kingdom (A.T., H.M., M.M., S.G.); and the Department of Thoracic-Head and Neck Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston (V.A.P.).

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http://dx.doi.org/10.1056/NEJMoa1612674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6762027PMC
February 2017

An Anaplastic Lymphoma Kinase Immunohistochemistry-Negative but Fluorescence In Situ Hybridization-Positive Lung Adenocarcinoma Is Resistant to Crizotinib.

J Thorac Oncol 2016 12 6;11(12):2248-2252. Epub 2016 Sep 6.

University Health Network, Ontario Cancer Institute/Princess Margaret Cancer Centre, Toronto, Ontario, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jtho.2016.08.139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573599PMC
December 2016

Response to Yamamoto et al.

J Thorac Oncol 2016 10;11(10):e129-30

Princess Margaret Cancer Centre, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.jtho.2016.08.130DOI Listing
October 2016

Cetuximab Inhibits T790M-Mediated Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor in a Lung Adenocarcinoma Patient-Derived Xenograft Mouse Model.

Clin Lung Cancer 2016 09 22;17(5):375-383.e2. Epub 2016 Jan 22.

Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cllc.2016.01.002DOI Listing
September 2016

Nivolumab in Combination With Platinum-Based Doublet Chemotherapy for First-Line Treatment of Advanced Non-Small-Cell Lung Cancer.

J Clin Oncol 2016 09 27;34(25):2969-79. Epub 2016 Jun 27.

Naiyer A. Rizvi and Matthew D. Hellmann, Memorial Sloan Kettering Cancer Center, New York, NY; Julie R. Brahmer, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD; Rosalyn A. Juergens, Juravinski Cancer Centre at McMaster University, Hamilton; Scott A. Laurie, Ottawa Hospital Cancer Centre, Ottawa; Frances A. Shepherd, Princess Margaret Cancer Centre, Toronto, Ontario, Canada; Hossein Borghaei, Fox Chase Cancer Center, Philadelphia, PA; Scott Gettinger, Yale Cancer Center, New Haven, CT; Laura Q. Chow, University of Washington, Seattle, WA; David E. Gerber, University of Texas Southwestern Medical Center, Dallas, TX; Jonathan W. Goldman, University of California, Los Angeles, Los Angeles, CA; Allen C. Chen, Yun Shen, Faith E. Nathan, and Christopher T. Harbison, Bristol-Myers Squibb, Princeton, NJ; and Scott Antonia, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.

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http://ascopubs.org/doi/10.1200/JCO.2016.66.9861
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http://dx.doi.org/10.1200/JCO.2016.66.9861DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5569693PMC
September 2016

Nivolumab Monotherapy for First-Line Treatment of Advanced Non-Small-Cell Lung Cancer.

J Clin Oncol 2016 09 27;34(25):2980-7. Epub 2016 Jun 27.

Scott Gettinger, Yale Cancer Center, New Haven, CT; Naiyer A. Rizvi and Matthew D. Hellmann, Memorial Sloan Kettering Cancer Center, New York, NY; Laura Q. Chow, University of Washington, Seattle, WA; Hossein Borghaei, Fox Chase Cancer Center, Philadelphia, PA; Julie Brahmer, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD; Neal Ready, Duke University Medical Center, Durham, NC; David E. Gerber, University of Texas Southwestern Medical Center, Dallas, TX; Frances A. Shepherd, Princess Margaret Cancer Centre, Toronto; Rosalyn A. Juergens, Juravinski Cancer Centre at McMaster University, Hamilton; Scott A. Laurie, Ottawa Hospital Cancer Centre, Ottawa, Ontario, Canada; Scott Antonia, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL; Jonathan W. Goldman, University of California, Los Angeles, Los Angeles, CA; and Faith E. Nathan, Yun Shen, and Christopher T. Harbison, Bristol-Myers Squibb, Princeton, NJ.

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http://dx.doi.org/10.1200/JCO.2016.66.9929DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5569692PMC
September 2016

Prognostic and Predictive Effect of TP53 Mutations in Patients with Non-Small Cell Lung Cancer from Adjuvant Cisplatin-Based Therapy Randomized Trials: A LACE-Bio Pooled Analysis.

J Thorac Oncol 2016 06 17;11(6):850-61. Epub 2016 Feb 17.

International Agency for Research on Cancer, Lyon, France; Department of Medical Oncology and Hematology, University Health Network, Princess Margaret Cancer Centre, University of Toronto, Toronto, Ontario, Canada; Department of Pathology, Centre Hospitalier Universitaire, Grenoble, France; International Prevention Research Institute, Lyon, France. Electronic address:

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http://dx.doi.org/10.1016/j.jtho.2016.02.002DOI Listing
June 2016

Prognostic Effect of Tumor Lymphocytic Infiltration in Resectable Non-Small-Cell Lung Cancer.

J Clin Oncol 2016 Apr 1;34(11):1223-30. Epub 2016 Feb 1.

Elisabeth Brambilla and Sylvie Lantuejoul, Institut Albert Bonniot-Institut National de la Santé et de la Recherche Médicale U823; and Centre Hospitalier Universitaire Albert Michallon, Grenoble; Gwénaël Le Teuff, Sophie Marguet, Ariane Dunant, Thierry Le Chevalier, and Jean-Charles Soria, Institut Gustave Roussy, Villejuif; Gwénaël Le Teuff, Sophie Marguet, Ariane Dunant, Thierry Le Chevalier, and Jean-Charles Soria, Université Paris-Sud, Orsay; Gwénaël Le Teuff, Université Paris-Saclay, Saint-Aubin; Jean-Yves Douillard, Centre René Gauducheau Institut de Cancerologie de l'Ouest, Saint-Herblain, France; Stephen Graziano, State University of New York Upstate Medical University, Syracuse, NY; Robert Pirker and Martin Filipits, Medical University of Vienna, Vienna; Helmut Popper, Medical University of Graz, Graz, Austria; Rafael Rosell, Catalan Institute of Oncology, Barcelona, Spain; Robert Kratzke, University of Minnesota, Minneapolis, MN; Frances A. Shepherd and Ming Sound Tsao, Princess Margaret Cancer Centre; Frances A. Shepherd and Ming Sound Tsao, University of Toronto, Toronto; and Lesley Seymour, Queen's University, Kingston, Ontario, Canada.

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http://dx.doi.org/10.1200/JCO.2015.63.0970DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872323PMC
April 2016

Should EGFR tyrosine kinase inhibitors be used in non-small cell lung cancer in the absence of EGFR mutations? Yes, there is a role for EGFR TKIs in these patients.

Clin Adv Hematol Oncol 2016 Jan;14(1):41-3

University of Toronto Faculty of Medicine and Princess Margaret Cancer Centre, Toronto, Ontario, Canada.

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January 2016

Adjuvant Erlotinib Versus Placebo in Patients With Stage IB-IIIA Non-Small-Cell Lung Cancer (RADIANT): A Randomized, Double-Blind, Phase III Trial.

J Clin Oncol 2015 Dec 31;33(34):4007-14. Epub 2015 Aug 31.

Karen Kelly, University of California, Davis, Comprehensive Cancer Center, Sacramento, CA; Nasser K. Altorki, New York Presbyterian Hospital-Weill Cornell Medical Center, New York, NY; Wilfried E.E. Eberhardt, University Hospital Essen, Essen, Germany; Mary E.R. O'Brien, Royal Marsden Hospital, London, United Kingdom; David R. Spigel, Sarah Cannon Research Institute, Nashville, TN; Lucio Crinò, Ospedale S. Maria della Misericordia, Perugia, Italy; Chun-Ming Tsai, Taipei General Hospital and National Yang-Ming University, Taipei, Taiwan; Joo-Hang Kim, Yonsei University Health System, Seoul; Eun Kyung Cho, Gachon University, Incheon, Korea; Philip C. Hoffman, The University of Chicago Medical Center, Chicago; Jiuzhou Wang and Margaret A. Foley, Astellas Pharma, Northbrook, IL; Sergey V. Orlov, I.P. Pavlov Medical University, St Petersburg, Russia; Piotr Serwatowski, Specjalistyczny Szpital, Sokolowskiego, Szczecin, Poland; Julie D. Horan, Novella Clinical, Boulder, CO; and Frances A. Shepherd, Princess Margaret Cancer Centre, University of Toronto, Toronto, Ontario, Canada.

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http://jco.ascopubs.org/content/early/2015/08/31/JCO.2015.61
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December 2015

Analysis of serum protein levels of angiogenic factors and their soluble receptors as markers of response to cediranib in the NCIC CTG BR.24 clinical trial.

Lung Cancer 2015 Nov 16;90(2):288-95. Epub 2015 Sep 16.

Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre University Health Network, and the University of Toronto, 610 University Avenue, Toronto, Ontario M5G 2M9, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.lungcan.2015.09.004DOI Listing
November 2015

Subtype Classification of Lung Adenocarcinoma Predicts Benefit From Adjuvant Chemotherapy in Patients Undergoing Complete Resection.

J Clin Oncol 2015 Oct 27;33(30):3439-46. Epub 2015 Apr 27.

Ming-Sound Tsao and Frances A. Shepherd, Princess Margaret Cancer Centre, University Health Network, and University of Toronto, Toronto; Lesley Seymour, NCIC Clinical Trials Group and Queen's University, Kingston, Ontario, Canada; Sophie Marguet, Gwénaël Le Teuff, Thierry Le-Chevalier, Jean-Pierre Pignon, and Jean-Charles Soria, Gustave Roussy, Villejuif; Sylvie Lantuejoul and Elisabeth M. Brambilla, Inserm U823, Centre Hospitalier Universitaire de Grenoble, Institut Albert Bonniot, Université Joseph Fourier, Grenoble; Jean-Yves Douillard, Centre René Gauducheau, Saint-Herblain, Nantes, France; Robert Kratzke, University of Minnesota, Minneapolis, MN; Stephen L. Graziano, SUNY Upstate Medical University, Syracuse, NY; Helmut H. Popper, Institute of Pathology, University Medical School of Graz, Graz, Austria; and Rafael Rosell, Catalan Institute of Oncology, Barcelona, Spain.

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http://dx.doi.org/10.1200/JCO.2014.58.8335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4606061PMC
October 2015

Central Nervous System Pseudoprogression in a Patient Treated with PD-1 Checkpoint Inhibitor.

J Thorac Oncol 2015 Oct;10(10):e100-1

*Department of Medical Oncology and Haematology, Princess Margaret Cancer Centre, University of Toronto, Toronto, Ontario, Canada; and †Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/JTO.0000000000000587DOI Listing
October 2015

PTPRF Expression as a Potential Prognostic/Predictive Marker for Treatment with Erlotinib in Non-Small-Cell Lung Cancer.

J Thorac Oncol 2015 Sep;10(9):1364-1369

Department of Oncology Biomarkers, Genentech Inc., SanFrancisco, California. Electronic address:

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http://dx.doi.org/10.1097/JTO.0000000000000624DOI Listing
September 2015

Clinical Utility of Patient-Derived Xenografts to Determine Biomarkers of Prognosis and Map Resistance Pathways in EGFR-Mutant Lung Adenocarcinoma.

J Clin Oncol 2015 Aug 29;33(22):2472-80. Epub 2015 Jun 29.

Erin L. Stewart, Celine Mascaux, Nhu-An Pham, Shingo Sakashita, Jenna Sykes, Lucia Kim, Naoki Yanagawa, Ghassan Allo, Kota Ishizawa, Dennis Wang, Chang-Qi Zhu, Ming Li, Christine Ng, Ni Liu, Melania Pintilie, Petra Martin, Tom John, Igor Jurisica, Natasha B. Leighl, Benjamin G. Neel, Thomas K. Waddell, Frances A. Shepherd, Geoffrey Liu, Ming-Sound Tsao, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada; Lucia Kim, Inha University College of Medicine, Incheon, South Korea; and Tom John, Austin Hospital, Heidelberg, Australia.

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http://200.40.135.66:90/toc/0873/2015/0873-20150801-22-09.pd
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http://jco.ascopubs.org/cgi/doi/10.1200/JCO.2014.60.1492
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August 2015

Phase III Multinational, Randomized, Double-Blind, Placebo-Controlled Study of Tivantinib (ARQ 197) Plus Erlotinib Versus Erlotinib Alone in Previously Treated Patients With Locally Advanced or Metastatic Nonsquamous Non-Small-Cell Lung Cancer.

J Clin Oncol 2015 Aug 13;33(24):2667-74. Epub 2015 Jul 13.

Giorgio Scagliotti and Silvia Novello, University of Turin, Orbassano, Torino; Adolfo Favaretto, Istituto Oncologico Veneto, Padova; Armando Santoro, Istituto Clinico Humanitas, Milan, Italy; Joachim von Pawel, Asklepios-Fachkliniken München-Gauting, Munich, Germany; Rodryg Ramlau, Poznań University of Medical Sciences, Poznań, Poland; Fabrice Barlesi, Aix Marseille University, Assistance Publique Hôpitaux de Marseille, Marseille, France; Wallace Akerley, Huntsman Cancer Institute, Salt Lake City, UT; Sergey Orlov, St Petersburg State Medical University, St Petersburg, Russian Federation; David Spigel, Clinical Locations, Nashville, TN; Vera Hirsh, McGill University Health Centre, Montreal, Quebec; Frances A. Shepherd, Princess Margaret Cancer Centre, Toronto, Ontario, Canada; Lecia V. Sequist, Massachusetts General Hospital, Boston; Jeffrey S. Ross, Foundation Medicine, Cambridge; Brian Schwartz, ArQule, Woburn, MA; Alan Sandler, Genentech, San Francisco, CA; and Qiang Wang, Reinhard von Roemeling, and Dale Shuster, Daiichi Sankyo, Edison, NJ.

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http://dx.doi.org/10.1200/JCO.2014.60.7317DOI Listing
August 2015

Inhibiting MDM2-p53 Interaction Suppresses Tumor Growth in Patient-Derived Non-Small Cell Lung Cancer Xenograft Models.

J Thorac Oncol 2015 Aug;10(8):1172-80

*Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada; ‡Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; and §Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1097/JTO.0000000000000584DOI Listing
August 2015

Cabazitaxel Versus Topotecan in Patients with Small-Cell Lung Cancer with Progressive Disease During or After First-Line Platinum-Based Chemotherapy.

J Thorac Oncol 2015 Aug;10(8):1221-8

*Perelman Center for Advanced Medicine, Philadelphia, Pennsylvania; †Yonsei Cancer Center, Yonsei University Health System, Seoul, Republic of Korea; ‡Korányi National Institute of Pulmonology, Budapest, Hungary; §Klinikum Loewenstein, Loewenstein, Germany; ‖Princess Margaret Cancer Centre, Toronto, Ontario, Canada; ¶Vall d'Hebron Institute of Oncology, Barcelona, Spain; #Oncology Department, Poznan University of Medical Sciences, Poznan, Poland; **Oncology Unit, 3rd Department of Medicine, Athens University School of Medicine, Sotiria General Hospital, Athens, Greece; ††Sanofi, Bridgewater, New Jersey; ‡‡Sanofi, Vitry-sur-Seine, France; and §§Division of Haematology and Oncology, Klinikum Kassel, Kassel, Germany.

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http://dx.doi.org/10.1097/JTO.0000000000000588DOI Listing
August 2015

NRF2 Pathway Activation and Adjuvant Chemotherapy Benefit in Lung Squamous Cell Carcinoma.

Clin Cancer Res 2015 Jun 4;21(11):2499-505. Epub 2015 Mar 4.

Department of Pathology, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada.

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http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
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http://dx.doi.org/10.1158/1078-0432.CCR-14-2206DOI Listing
June 2015

Diffuse Hemorrhagic Brain Metastases in an ALK Fusion Positive Patient on Crizotinib.

J Thorac Oncol 2015 Jun;10(6):965-6

University Health Network, Department of Oncology and Hematology, Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1097/JTO.0000000000000403DOI Listing
June 2015