Frances M Ashcroft

Frances M Ashcroft

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Frances M Ashcroft

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Low extracellular magnesium does not impair glucose-stimulated insulin secretion.

PLoS One 2019 4;14(6):e0217925. Epub 2019 Jun 4.

Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0217925PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548430PMC
February 2020

Nucleotide inhibition of the pancreatic ATP-sensitive K+ channel explored with patch-clamp fluorometry.

Elife 2020 Jan 7;9. Epub 2020 Jan 7.

Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.7554/eLife.52775DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7004565PMC
January 2020

Correction to: Q&A: insulin secretion and type 2 diabetes: why do β-cells fail?

BMC Biol 2019 04 9;17(1):32. Epub 2019 Apr 9.

Department of Physiology, Anatomy & Genetics, University of Oxford, Parks Road, Oxford, OX1 3PT, UK.

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http://dx.doi.org/10.1186/s12915-019-0650-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456947PMC
April 2019

Dysregulation of Glucagon Secretion by Hyperglycemia-Induced Sodium-Dependent Reduction of ATP Production.

Cell Metab 2019 02 8;29(2):430-442.e4. Epub 2018 Nov 8.

Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 7LE, UK; Metabolic Research, Department of Neuroscience and Physiology, Sahlgrenska Academy, University of Göteborg, Box 433, Göteborg 405 30, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2018.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370947PMC
February 2019

Binding of sulphonylureas to plasma proteins - A KATP channel perspective.

PLoS One 2018 17;13(5):e0197634. Epub 2018 May 17.

Oxford Centre for Gene Function, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0197634PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5957440PMC
December 2018

Role of the C-terminus of SUR in the differential regulation of β-cell and cardiac K channels by MgADP and metabolism.

J Physiol 2018 12 14;596(24):6205-6217. Epub 2018 Oct 14.

Henry Wellcome Centre for Gene Function, Department of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, Oxford, OX1 3PT, UK.

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http://dx.doi.org/10.1113/JP276708DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292810PMC
December 2018

Magnesium deficiency prevents high-fat-diet-induced obesity in mice.

Diabetologia 2018 09 9;61(9):2030-2042. Epub 2018 Jul 9.

Department of Physiology (286), Radboud Institute for Molecular Life Sciences, Radboud university medical center, P. O. Box 9101, 6500 HB, Nijmegen, the Netherlands.

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http://dx.doi.org/10.1007/s00125-018-4680-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096631PMC
September 2018

Monitoring real-time hormone release kinetics via high-content 3-D imaging of compensatory endocytosis.

Lab Chip 2018 09;18(18):2838-2848

Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, University of Oxford, Headington, OX3 7LE, Oxford, UK. and Oxford National Institute for Health Research, Biomedical Research Centre, Churchill Hospital, Oxford OX3 7LE, UK and Institute of Neuroscience of Physiology, Department of Physiology, Metabolic Research Unit, University of Göteborg, Box 430, SE-405 30 Göteborg, Sweden.

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http://dx.doi.org/10.1039/c8lc00417jDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250124PMC
September 2018

Influences: Find a friend.

J Gen Physiol 2018 07 21;150(7):895-896. Epub 2018 Jun 21.

University of Oxford, Oxford, England, UK

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http://dx.doi.org/10.1085/jgp.201812123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028500PMC
July 2018

Cardiac Dysfunction and Metabolic Inflexibility in a Mouse Model of Diabetes Without Dyslipidemia.

Diabetes 2018 06 2;67(6):1057-1067. Epub 2018 Apr 2.

Department of Physiology, Anatomy and Genetics and OXION, University of Oxford, Oxford, U.K.

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http://dx.doi.org/10.2337/db17-1195DOI Listing
June 2018

FTO demethylase activity is essential for normal bone growth and bone mineralization in mice.

Biochim Biophys Acta Mol Basis Dis 2018 Mar 2;1864(3):843-850. Epub 2017 Dec 2.

Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2017.11.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798602PMC
March 2018

Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men.

Physiol Rev 2018 01;98(1):117-214

Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, United Kingdom; Department of Neuroscience and Physiology, Metabolic Research Unit, Göteborg, Sweden; and Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.

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http://www.physiology.org/doi/10.1152/physrev.00008.2017
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http://dx.doi.org/10.1152/physrev.00008.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866358PMC
January 2018

An Nonsense Mutation Causing Neonatal Diabetes Through Altered Transcript Expression.

J Clin Res Pediatr Endocrinol 2017 Sep 30;9(3):260-264. Epub 2017 Jun 30.

University of Exeter Medical School, Institute of Biomedical and Clinical Science, Department of Molecular Genetics, Exeter, United Kingdom.

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http://dx.doi.org/10.4274/jcrpe.4624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596808PMC
September 2017

Is Type 2 Diabetes a Glycogen Storage Disease of Pancreatic β Cells?

Cell Metab 2017 Jul;26(1):17-23

Department of Physiology, Anatomy, and Genetics and OXION, University of Oxford, Parks Road, Oxford OX1 3PT, UK.

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http://dx.doi.org/10.1016/j.cmet.2017.05.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890904PMC
July 2017

Neonatal Diabetes and the K Channel: From Mutation to Therapy.

Trends Endocrinol Metab 2017 05 3;28(5):377-387. Epub 2017 Mar 3.

Henry Wellcome Centre for Gene Function, Department of Physiology, Anatomy and Genetics, University of Oxford, OX1 3PT, UK.

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http://dx.doi.org/10.1016/j.tem.2017.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5582192PMC
May 2017

Functional identification of islet cell types by electrophysiological fingerprinting.

J R Soc Interface 2017 03;14(128)

Oxford Centre for Diabetes, Endocrinology, and Metabolism, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford OX3 7LE, UK.

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http://rsif.royalsocietypublishing.org/lookup/doi/10.1098/rs
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http://dx.doi.org/10.1098/rsif.2016.0999DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378133PMC
March 2017

Pancreatic β-Cells Express the Fetal Islet Hormone Gastrin in Rodent and Human Diabetes.

Diabetes 2017 02 18;66(2):426-436. Epub 2016 Nov 18.

Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University Hadassah Medical School, Jerusalem, Israel

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http://dx.doi.org/10.2337/db16-0641DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5248995PMC
February 2017

Running out of time: the decline of channel activity and nucleotide activation in adenosine triphosphate-sensitive K-channels.

Philos Trans R Soc Lond B Biol Sci 2016 08;371(1700)

Department of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, Oxford OX1 3PT, UK

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http://dx.doi.org/10.1098/rstb.2015.0426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938026PMC
August 2016

Systemic Administration of Glibenclamide Fails to Achieve Therapeutic Levels in the Brain and Cerebrospinal Fluid of Rodents.

PLoS One 2015 30;10(7):e0134476. Epub 2015 Jul 30.

Department of Physiology, Anatomy and Genetics and OXION, University of Oxford, Oxford, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0134476PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520580PMC
May 2016

The Nucleotide-Binding Sites of SUR1: A Mechanistic Model.

Biophys J 2015 Dec;109(12):2452-2460

Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2015.10.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4699857PMC
December 2015

Q&A: insulin secretion and type 2 diabetes: why do β-cells fail?

BMC Biol 2015 May 16;13:33. Epub 2015 May 16.

Department of Physiology, Anatomy & Genetics, University of Oxford, Parks Road, Oxford, OX1 3PT, UK.

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http://dx.doi.org/10.1186/s12915-015-0140-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4435650PMC
May 2015

Changes in gene expression associated with FTO overexpression in mice.

PLoS One 2014 19;9(5):e97162. Epub 2014 May 19.

Henry Wellcome Centre for Gene Function, Department of Physiology, Anatomy; and Genetics, University of Oxford, Parks Road, Oxford, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0097162PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026227PMC
December 2014

Na+ current properties in islet α- and β-cells reflect cell-specific Scn3a and Scn9a expression.

J Physiol 2014 Nov 28;592(21):4677-96. Epub 2014 Aug 28.

Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, OX3 7LJ, UK Department of Neuroscience and Physiology, Sahlgren's Academy, University of Göteborg, Box 430, SE40530, Göteborg, Sweden

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http://dx.doi.org/10.1113/jphysiol.2014.274209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4253470PMC
November 2014

Sulfonylureas suppress the stimulatory action of Mg-nucleotides on Kir6.2/SUR1 but not Kir6.2/SUR2A KATP channels: a mechanistic study.

J Gen Physiol 2014 Nov;144(5):469-86

Oxford Centre for Gene Function and Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford OX1 3PT, England, UK Oxford Centre for Gene Function and Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford OX1 3PT, England, UK

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http://dx.doi.org/10.1085/jgp.201411222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210431PMC
November 2014

Reversible changes in pancreatic islet structure and function produced by elevated blood glucose.

Nat Commun 2014 Aug 22;5:4639. Epub 2014 Aug 22.

Henry Wellcome Centre for Gene Function, Department of Physiology, Anatomy and Genetics and OXION, University of Oxford, Parks Road, Oxford OX1 3PT, UK.

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http://dx.doi.org/10.1038/ncomms5639DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143961PMC
August 2014

A mutation causing increased KATP channel activity leads to reduced anxiety in mice.

Physiol Behav 2014 Apr 25;129:79-84. Epub 2014 Feb 25.

Henry Wellcome Centre for Gene Function, Department of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, Oxford OX1 3PT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.physbeh.2014.02.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5576528PMC
April 2014

Type 2 diabetes and congenital hyperinsulinism cause DNA double-strand breaks and p53 activity in β cells.

Cell Metab 2014 Jan 12;19(1):109-21. Epub 2013 Dec 12.

Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2013.11.007DOI Listing
January 2014

Gain-of-function mutations in the K(ATP) channel (KCNJ11) impair coordinated hand-eye tracking.

PLoS One 2013 23;8(4):e62646. Epub 2013 Apr 23.

Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, Oxfordshire, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0062646PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3633835PMC
November 2013

Molecular mechanism of sulphonylurea block of K(ATP) channels carrying mutations that impair ATP inhibition and cause neonatal diabetes.

Diabetes 2013 Nov 8;62(11):3909-19. Epub 2013 Jul 8.

Henry Wellcome Centre for Gene Function, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, U.K.

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http://dx.doi.org/10.2337/db13-0531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806600PMC
November 2013

K(ATP) channels and islet hormone secretion: new insights and controversies.

Nat Rev Endocrinol 2013 Nov 17;9(11):660-9. Epub 2013 Sep 17.

Henry Wellcome Centre for Gene Function, Department of Physiology, Anatomy and Genetics, Parks Road, Oxford OX1 3PT, UK.

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http://dx.doi.org/10.1038/nrendo.2013.166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890885PMC
November 2013

Tetrameric structure of SUR2B revealed by electron microscopy of oriented single particles.

FEBS J 2013 Feb 27;280(4):1051-63. Epub 2013 Jan 27.

Department of Physiology, Henry Wellcome Centre for Gene Function, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1111/febs.12097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599479PMC
February 2013

Role for the obesity-related FTO gene in the cellular sensing of amino acids.

Proc Natl Acad Sci U S A 2013 Feb 28;110(7):2557-62. Epub 2013 Jan 28.

University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, and National Institute for Health Research Cambridge Biomedical Research Centre, Addenbrooke's Hospital, Cambridge CB2 0QQ, United Kingdom.

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http://dx.doi.org/10.1073/pnas.1222796110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3574930PMC
February 2013

Mouse Models of β-cell K Channel Dysfunction.

Drug Discov Today Dis Models 2013 ;10(2):e101-e109

Henry Wellcome Centre for Gene Function, Department of Physiology, Anatomy and Genetics, and OXION Centre for Ion Channel Studies, Sherrington Building, Parks Road, Oxford OX1 3PT, UK.

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http://dx.doi.org/10.1016/j.ddmod.2013.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890883PMC
January 2013

A universally conserved residue in the SUR1 subunit of the KATP channel is essential for translating nucleotide binding at SUR1 into channel opening.

J Physiol 2012 Oct 16;590(20):5025-36. Epub 2012 Jul 16.

Henry Wellcome Centre for Gene Function, Department of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, Oxford OX1 3PT, UK.

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http://dx.doi.org/10.1113/jphysiol.2012.236075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495298PMC
October 2012

FTO is expressed in neurones throughout the brain and its expression is unaltered by fasting.

PLoS One 2011 30;6(11):e27968. Epub 2011 Nov 30.

Department of Physiology, Anatomy and Genetics, OXION Centre for Ion Channel Studies, Henry Wellcome Centre for Gene Function, Oxford, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0027968PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3227617PMC
April 2012

Diabetes mellitus and the β cell: the last ten years.

Cell 2012 Mar;148(6):1160-71

Department of Physiology, Anatomy, and Genetics, Henry Wellcome Centre for Gene Function, University of Oxford, Sherrington Building, Parks Road, Oxford OX1 3PT, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S00928674120020
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http://dx.doi.org/10.1016/j.cell.2012.02.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890906PMC
March 2012

A high-throughput assay for modulators of NNT activity in permeabilized yeast cells.

J Biomol Screen 2011 Aug 20;16(7):734-43. Epub 2011 May 20.

Medical Research Council, Mammalian Genetics Unit, Harwell Science and Innovation Campus, Oxfordshire, United Kingdom.

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http://dx.doi.org/10.1177/1087057111408088DOI Listing
August 2011

A conserved tryptophan at the membrane-water interface acts as a gatekeeper for Kir6.2/SUR1 channels and causes neonatal diabetes when mutated.

J Physiol 2011 Jul 3;589(Pt 13):3071-83. Epub 2011 May 3.

Henry Wellcome Centre for Gene Function, Department of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, Oxford OX1 3PT, UK.

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http://dx.doi.org/10.1113/jphysiol.2011.209700DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3145925PMC
July 2011

Control of pancreatic β cell regeneration by glucose metabolism.

Cell Metab 2011 Apr;13(4):440-449

Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2011.02.012DOI Listing
April 2011

Chronic Palmitate Exposure Inhibits Insulin Secretion by Dissociation of Ca Channels from Secretory Granules.

Cell Metab 2011 Apr 5;13(4):487. Epub 2011 Apr 5.

The Oxford Centre for Diabetes, Endocrinology, and Metabolism, Churchill Hospital, Oxford OX3 7LJ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2011.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628175PMC
April 2011

Overexpression of Fto leads to increased food intake and results in obesity.

Nat Genet 2010 Dec 14;42(12):1086-92. Epub 2010 Nov 14.

MRC Harwell, Metabolism and Inflammation, Harwell Science and Innovation Campus, Harwell, UK.

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http://dx.doi.org/10.1038/ng.713DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018646PMC
December 2010

Activation of the K(ATP) channel by Mg-nucleotide interaction with SUR1.

J Gen Physiol 2010 Oct;136(4):389-405

Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, England, UK.

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http://dx.doi.org/10.1085/jgp.201010475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947056PMC
October 2010

The role of the KATP channel in glucose homeostasis in health and disease: more than meets the islet.

J Physiol 2010 Sep 2;588(Pt 17):3201-9. Epub 2010 Jun 2.

Henry Wellcome Centre for Gene Function, Department of Physiology, Anatomy and Genetics, and OXION Centre for Ion Channel Studies, Sherrington Building, Parks Road, Oxford OX1 3PT, UK.

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http://dx.doi.org/10.1113/jphysiol.2010.191767DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2976015PMC
September 2010

Muscle dysfunction caused by a KATP channel mutation in neonatal diabetes is neuronal in origin.

Science 2010 Jul 1;329(5990):458-61. Epub 2010 Jul 1.

Department of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, Oxford, OX1 3PT, UK.

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http://dx.doi.org/10.1126/science.1186146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890903PMC
July 2010

Asymmetric switching in a homodimeric ABC transporter: a simulation study.

PLoS Comput Biol 2010 Apr 29;6(4):e1000762. Epub 2010 Apr 29.

Department of Biochemistry, University of Oxford, Oxford, United Kingdom.

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http://dx.plos.org/10.1371/journal.pcbi.1000762
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http://dx.doi.org/10.1371/journal.pcbi.1000762DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2861673PMC
April 2010

Interaction between mutations in the slide helix of Kir6.2 associated with neonatal diabetes and neurological symptoms.

Hum Mol Genet 2010 Mar 18;19(6):963-72. Epub 2009 Dec 18.

Henry Wellcome Centre for Gene Function, Department of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, Oxford OX1 3PT, UK.

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http://dx.doi.org/10.1093/hmg/ddp554DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2830823PMC
March 2010

New uses for old drugs: neonatal diabetes and sulphonylureas.

Cell Metab 2010 Mar;11(3):179-81

Henry Wellcome Centre for Gene Function, Department of Physiology, Anatomy and Genetics, University of Oxford, UK.

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http://dx.doi.org/10.1016/j.cmet.2010.02.004DOI Listing
March 2010

CLC-5 and KIF3B interact to facilitate CLC-5 plasma membrane expression, endocytosis, and microtubular transport: relevance to pathophysiology of Dent's disease.

Am J Physiol Renal Physiol 2010 Feb 25;298(2):F365-80. Epub 2009 Nov 25.

Academic Endocrine Unit, Nuffield Department of Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology, and Metabolism, Churchill Hospital, Oxford, United Kingdom.

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http://dx.doi.org/10.1152/ajprenal.00038.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822520PMC
February 2010

PIP(2)-binding site in Kir channels: definition by multiscale biomolecular simulations.

Biochemistry 2009 Nov;48(46):10926-33

Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK.

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http://pubs.acs.org/doi/abs/10.1021/bi9013193
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http://dx.doi.org/10.1021/bi9013193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895862PMC
November 2009

An in-frame deletion in Kir6.2 (KCNJ11) causing neonatal diabetes reveals a site of interaction between Kir6.2 and SUR1.

J Clin Endocrinol Metab 2009 Jul 7;94(7):2551-7. Epub 2009 Apr 7.

Henry Wellcome Centre for Gene Function, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, United Kingdom.

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http://dx.doi.org/10.1210/jc.2009-0159DOI Listing
July 2009

A cytosolic factor that inhibits KATP channels expressed in Xenopus oocytes by impairing Mg-nucleotide activation by SUR1.

J Physiol 2009 Apr 23;587(Pt 8):1649-56. Epub 2009 Feb 23.

Department of Physiology, Anatomy and Genetics, Parks Road, Oxford OX1 3PT, UK.

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http://doi.wiley.com/10.1113/jphysiol.2008.165126
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http://dx.doi.org/10.1113/jphysiol.2008.165126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2683953PMC
April 2009

Modeling K(ATP) channel gating and its regulation.

Prog Biophys Mol Biol 2009 Jan 17;99(1):7-19. Epub 2008 Oct 17.

Henry Wellcome Centre for Gene Function, Department of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, Oxford OX1 3PT, UK.

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http://dx.doi.org/10.1016/j.pbiomolbio.2008.10.002DOI Listing
January 2009

Review. SUR1: a unique ATP-binding cassette protein that functions as an ion channel regulator.

Philos Trans R Soc Lond B Biol Sci 2009 Jan;364(1514):257-67

Department of Physiology, Henry Wellcome Centre for Gene Function, University of Oxford, Parks Road, Oxford, UK.

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http://dx.doi.org/10.1098/rstb.2008.0142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2674095PMC
January 2009

How ATP inhibits the open K(ATP) channel.

J Gen Physiol 2008 Jul;132(1):131-44

Henry Wellcome Centre for Gene Function, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2442177PMC
July 2008

Glucose regulates the effects of leptin on hypothalamic POMC neurons.

Proc Natl Acad Sci U S A 2008 Jul 3;105(28):9811-6. Epub 2008 Jul 3.

Henry Wellcome Center for Gene Function, Department of Physiology, Anatomy, and Genetics, University of Oxford, Parks Road, Oxford OX1 3PT, United Kingdom.

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http://dx.doi.org/10.1073/pnas.0800952105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2443183PMC
July 2008

Reduced expression of Kir6.2/SUR2A subunits explains KATP deficiency in K+-depleted rats.

Neuromuscul Disord 2008 Jan 6;18(1):74-80. Epub 2007 Sep 6.

Department of Pharmacobiology, Faculty of Pharmacy, University of Bari, via Orabona no 4, 70120 Bari, Italy.

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http://dx.doi.org/10.1016/j.nmd.2007.07.009DOI Listing
January 2008

Mosaic paternal uniparental isodisomy and an ABCC8 gene mutation in a patient with permanent neonatal diabetes and hemihypertrophy.

Diabetes 2008 Jan 17;57(1):255-8. Epub 2007 Oct 17.

Department of Endocrinology and Diabetes, Bristol Royal Hospital for Children and University of Bristol, Bristol, UK.

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http://dx.doi.org/10.2337/db07-0999DOI Listing
January 2008

A mutation in the ATP-binding site of the Kir6.2 subunit of the KATP channel alters coupling with the SUR2A subunit.

J Physiol 2007 Nov 13;584(Pt 3):743-53. Epub 2007 Sep 13.

Department of Physiology, Anatomy and Genetics, Oxford University, Oxford, UK.

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http://doi.wiley.com/10.1113/jphysiol.2007.143149
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November 2007

Increased ATPase activity produced by mutations at arginine-1380 in nucleotide-binding domain 2 of ABCC8 causes neonatal diabetes.

Proc Natl Acad Sci U S A 2007 Nov 19;104(48):18988-92. Epub 2007 Nov 19.

Henry Wellcome Centre for Gene Function, Department of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, Oxford OX1 3PT, United Kingdom.

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November 2007

The Walter B. Cannon Physiology in Perspective Lecture, 2007. ATP-sensitive K+ channels and disease: from molecule to malady.

Am J Physiol Endocrinol Metab 2007 Oct 24;293(4):E880-9. Epub 2007 Jul 24.

Henry Wellcome Centre for Gene Function, Dept. of Physiology, Anatomy and Genetics, Univ. of Oxford, Parks Road, Oxford OX1 3PT, UK.

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October 2007

Mechanism of action of a sulphonylurea receptor SUR1 mutation (F132L) that causes DEND syndrome.

Hum Mol Genet 2007 Aug 21;16(16):2011-9. Epub 2007 Jun 21.

University Laboratory of Physiology, Oxford University, Oxford, UK.

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http://dx.doi.org/10.1093/hmg/ddm149DOI Listing
August 2007

Identification of the PIP2-binding site on Kir6.2 by molecular modelling and functional analysis.

EMBO J 2007 Aug 2;26(16):3749-59. Epub 2007 Aug 2.

Department of Biochemistry, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/sj.emboj.7601809DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1952224PMC
August 2007

Studies of the ATPase activity of the ABC protein SUR1.

FEBS J 2007 Jul 11;274(14):3532-3544. Epub 2007 Jun 11.

Henry Wellcome Centre for Gene Function, Department of Physiology, Anatomy and Genetics, University of Oxford, UKLaboratory of Molecular Biophysics, Department of Biochemistry, University of Oxford, UK.

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http://dx.doi.org/10.1111/j.1742-4658.2007.05879.xDOI Listing
July 2007

Glucagon-like peptide 1 stimulates hypothalamic proopiomelanocortin neurons.

J Neurosci 2007 Jul;27(27):7125-9

University Laboratory of Physiology, Oxford OX1 3PT, United Kingdom.

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http://dx.doi.org/10.1523/JNEUROSCI.1025-07.2007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868967PMC
July 2007

Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production.

Cell Metab 2007 Jun;5(6):438-49

Department of Mouse Genetics and Metabolism, Institute for Genetics, Center for Molecular Medicine, University of Cologne, D-50674 Cologne, Germany.

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http://dx.doi.org/10.1016/j.cmet.2007.05.004DOI Listing
June 2007

R-type Ca(2+)-channel-evoked CICR regulates glucose-induced somatostatin secretion.

Nat Cell Biol 2007 Apr 18;9(4):453-60. Epub 2007 Mar 18.

Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford OX3 7LJ, UK.

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April 2007