Fotios Loupakis

Fotios Loupakis

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Fotios Loupakis

Publications by authors named "Fotios Loupakis"

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An overview on clinical, pathological and molecular features of lung metastases from colorectal cancer.

Expert Rev Respir Med 2019 Jul 23;13(7):635-644. Epub 2019 May 23.

a Unit of Medical Oncology 1, Department of Clinical and Experimental Oncology , Istituto Oncologico Veneto IOV - IRCCS , Padova , Italia.

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http://dx.doi.org/10.1080/17476348.2019.1620605DOI Listing
July 2019

Quantitative evidence for early metastatic seeding in colorectal cancer.

Nat Genet 2019 Jul 17;51(7):1113-1122. Epub 2019 Jun 17.

Department of Medicine, Division of Oncology, Stanford University School of Medicine, Stanford, CA, USA.

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http://dx.doi.org/10.1038/s41588-019-0423-xDOI Listing
July 2019

Ramucirumab: the long and winding road toward being an option for mCRC treatment.

Expert Opin Biol Ther 2019 05 16;19(5):399-409. Epub 2019 Apr 16.

b Department of Oncology, Unit of Oncology 1 , Veneto Institute of Oncology, Scientific Institute for Research and Healthcare (IRCCS) , Padua , Italy.

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http://dx.doi.org/10.1080/14712598.2019.1600505DOI Listing
May 2019

Impact of polymorphisms within genes involved in regulating DNA methylation in patients with metastatic colorectal cancer enrolled in three independent, randomised, open-label clinical trials: a meta-analysis from TRIBE, MAVERICC and FIRE-3.

Eur J Cancer 2019 Apr 7;111:138-147. Epub 2019 Mar 7.

Division of Medical Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Department of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2019.01.105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436973PMC
April 2019

Novel Common Genetic Susceptibility Loci for Colorectal Cancer.

Authors:
Stephanie L Schmit Christopher K Edlund Fredrick R Schumacher Jian Gong Tabitha A Harrison Jeroen R Huyghe Chenxu Qu Marilena Melas David J Van Den Berg Hansong Wang Stephanie Tring Sarah J Plummer Demetrius Albanes M Henar Alonso Christopher I Amos Kristen Anton Aaron K Aragaki Volker Arndt Elizabeth L Barry Sonja I Berndt Stéphane Bezieau Stephanie Bien Amanda Bloomer Juergen Boehm Marie-Christine Boutron-Ruault Hermann Brenner Stefanie Brezina Daniel D Buchanan Katja Butterbach Bette J Caan Peter T Campbell Christopher S Carlson Jose E Castelao Andrew T Chan Jenny Chang-Claude Stephen J Chanock Iona Cheng Ya-Wen Cheng Lee Soo Chin James M Church Timothy Church Gerhard A Coetzee Michelle Cotterchio Marcia Cruz Correa Keith R Curtis David Duggan Douglas F Easton Dallas English Edith J M Feskens Rocky Fischer Liesel M FitzGerald Barbara K Fortini Lars G Fritsche Charles S Fuchs Manuela Gago-Dominguez Manish Gala Steven J Gallinger W James Gauderman Graham G Giles Edward L Giovannucci Stephanie M Gogarten Clicerio Gonzalez-Villalpando Elena M Gonzalez-Villalpando William M Grady Joel K Greenson Andrea Gsur Marc Gunter Christopher A Haiman Jochen Hampe Sophia Harlid John F Harju Richard B Hayes Philipp Hofer Michael Hoffmeister John L Hopper Shu-Chen Huang Jose Maria Huerta Thomas J Hudson David J Hunter Gregory E Idos Motoki Iwasaki Rebecca D Jackson Eric J Jacobs Sun Ha Jee Mark A Jenkins Wei-Hua Jia Shuo Jiao Amit D Joshi Laurence N Kolonel Suminori Kono Charles Kooperberg Vittorio Krogh Tilman Kuehn Sébastien Küry Andrea LaCroix Cecelia A Laurie Flavio Lejbkowicz Mathieu Lemire Heinz-Josef Lenz David Levine Christopher I Li Li Li Wolfgang Lieb Yi Lin Noralane M Lindor Yun-Ru Liu Fotios Loupakis Yingchang Lu Frank Luh Jing Ma Christoph Mancao Frank J Manion Sanford D Markowitz Vicente Martin Koichi Matsuda Keitaro Matsuo Kevin J McDonnell Caroline E McNeil Roger Milne Antonio J Molina Bhramar Mukherjee Neil Murphy Polly A Newcomb Kenneth Offit Hanane Omichessan Domenico Palli Jesus P Paredes Cotoré Julyann Pérez-Mayoral Paul D Pharoah John D Potter Conghui Qu Leon Raskin Gad Rennert Hedy S Rennert Bridget M Riggs Clemens Schafmayer Robert E Schoen Thomas A Sellers Daniela Seminara Gianluca Severi Wei Shi David Shibata Xiao-Ou Shu Erin M Siegel Martha L Slattery Melissa Southey Zsofia K Stadler Mariana C Stern Sebastian Stintzing Darin Taverna Stephen N Thibodeau Duncan C Thomas Antonia Trichopoulou Shoichiro Tsugane Cornelia M Ulrich Franzel J B van Duijnhoven Bethany van Guelpan Joseph Vijai Jarmo Virtamo Stephanie J Weinstein Emily White Aung Ko Win Alicja Wolk Michael Woods Anna H Wu Kana Wu Yong-Bing Xiang Yun Yen Brent W Zanke Yi-Xin Zeng Ben Zhang Niha Zubair Sun-Seog Kweon Jane C Figueiredo Wei Zheng Loic Le Marchand Annika Lindblom Victor Moreno Ulrike Peters Graham Casey Li Hsu David V Conti Stephen B Gruber

J Natl Cancer Inst 2019 Feb;111(2):146-157

Department of Preventive Medicine, USC Norris Comprehensive Cancer Center.

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http://dx.doi.org/10.1093/jnci/djy099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555904PMC
February 2019

Safety and Tolerability of c-MET Inhibitors in Cancer.

Drug Saf 2019 02;42(2):211-233

Division of Medical Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Suite 5410, Los Angeles, CA, 90033, USA.

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http://dx.doi.org/10.1007/s40264-018-0780-xDOI Listing
February 2019

Shared heritability and functional enrichment across six solid cancers.

Authors:
Xia Jiang Hilary K Finucane Fredrick R Schumacher Stephanie L Schmit Jonathan P Tyrer Younghun Han Kyriaki Michailidou Corina Lesseur Karoline B Kuchenbaecker Joe Dennis David V Conti Graham Casey Mia M Gaudet Jeroen R Huyghe Demetrius Albanes Melinda C Aldrich Angeline S Andrew Irene L Andrulis Hoda Anton-Culver Antonis C Antoniou Natalia N Antonenkova Susanne M Arnold Kristan J Aronson Banu K Arun Elisa V Bandera Rosa B Barkardottir Daniel R Barnes Jyotsna Batra Matthias W Beckmann Javier Benitez Sara Benlloch Andrew Berchuck Sonja I Berndt Heike Bickeböller Stephanie A Bien Carl Blomqvist Stefania Boccia Natalia V Bogdanova Stig E Bojesen Manjeet K Bolla Hiltrud Brauch Hermann Brenner James D Brenton Mark N Brook Joan Brunet Hans Brunnström Daniel D Buchanan Barbara Burwinkel Ralf Butzow Gabriella Cadoni Trinidad Caldés Maria A Caligo Ian Campbell Peter T Campbell Géraldine Cancel-Tassin Lisa Cannon-Albright Daniele Campa Neil Caporaso André L Carvalho Andrew T Chan Jenny Chang-Claude Stephen J Chanock Chu Chen David C Christiani Kathleen B M Claes Frank Claessens Judith Clements J Margriet Collée Marcia Cruz Correa Fergus J Couch Angela Cox Julie M Cunningham Cezary Cybulski Kamila Czene Mary B Daly Anna deFazio Peter Devilee Orland Diez Manuela Gago-Dominguez Jenny L Donovan Thilo Dörk Eric J Duell Alison M Dunning Miriam Dwek Diana M Eccles Christopher K Edlund Digna R Velez Edwards Carolina Ellberg D Gareth Evans Peter A Fasching Robert L Ferris Triantafillos Liloglou Jane C Figueiredo Olivia Fletcher Renée T Fortner Florentia Fostira Silvia Franceschi Eitan Friedman Steven J Gallinger Patricia A Ganz Judy Garber José A García-Sáenz Simon A Gayther Graham G Giles Andrew K Godwin Mark S Goldberg David E Goldgar Ellen L Goode Marc T Goodman Gary Goodman Kjell Grankvist Mark H Greene Henrik Gronberg Jacek Gronwald Pascal Guénel Niclas Håkansson Per Hall Ute Hamann Freddie C Hamdy Robert J Hamilton Jochen Hampe Aage Haugen Florian Heitz Rolando Herrero Peter Hillemanns Michael Hoffmeister Estrid Høgdall Yun-Chul Hong John L Hopper Richard Houlston Peter J Hulick David J Hunter David G Huntsman Gregory Idos Evgeny N Imyanitov Sue Ann Ingles Claudine Isaacs Anna Jakubowska Paul James Mark A Jenkins Mattias Johansson Mikael Johansson Esther M John Amit D Joshi Radka Kaneva Beth Y Karlan Linda E Kelemen Tabea Kühl Kay-Tee Khaw Elza Khusnutdinova Adam S Kibel Lambertus A Kiemeney Jeri Kim Susanne K Kjaer Julia A Knight Manolis Kogevinas Zsofia Kote-Jarai Stella Koutros Vessela N Kristensen Jolanta Kupryjanczyk Martin Lacko Stephan Lam Diether Lambrechts Maria Teresa Landi Philip Lazarus Nhu D Le Eunjung Lee Flavio Lejbkowicz Heinz-Josef Lenz Goska Leslie Davor Lessel Jenny Lester Douglas A Levine Li Li Christopher I Li Annika Lindblom Noralane M Lindor Geoffrey Liu Fotios Loupakis Jan Lubiński Lovise Maehle Christiane Maier Arto Mannermaa Loic Le Marchand Sara Margolin Taymaa May Lesley McGuffog Alfons Meindl Pooja Middha Austin Miller Roger L Milne Robert J MacInnis Francesmary Modugno Marco Montagna Victor Moreno Kirsten B Moysich Lorelei Mucci Kenneth Muir Anna Marie Mulligan Katherine L Nathanson David E Neal Andrew R Ness Susan L Neuhausen Heli Nevanlinna Polly A Newcomb Lisa F Newcomb Finn Cilius Nielsen Liene Nikitina-Zake Børge G Nordestgaard Robert L Nussbaum Kenneth Offit Edith Olah Ali Amin Al Olama Olufunmilayo I Olopade Andrew F Olshan Håkan Olsson Ana Osorio Hardev Pandha Jong Y Park Nora Pashayan Michael T Parsons Tanja Pejovic Kathryn L Penney Wilbert H M Peters Catherine M Phelan Amanda I Phipps Dijana Plaseska-Karanfilska Miranda Pring Darya Prokofyeva Paolo Radice Kari Stefansson Susan J Ramus Leon Raskin Gad Rennert Hedy S Rennert Elizabeth J van Rensburg Marjorie J Riggan Harvey A Risch Angela Risch Monique J Roobol Barry S Rosenstein Mary Anne Rossing Kim De Ruyck Emmanouil Saloustros Dale P Sandler Elinor J Sawyer Matthew B Schabath Johanna Schleutker Marjanka K Schmidt V Wendy Setiawan Hongbing Shen Erin M Siegel Weiva Sieh Christian F Singer Martha L Slattery Karina Dalsgaard Sorensen Melissa C Southey Amanda B Spurdle Janet L Stanford Victoria L Stevens Sebastian Stintzing Jennifer Stone Karin Sundfeldt Rebecca Sutphen Anthony J Swerdlow Eloiza H Tajara Catherine M Tangen Adonina Tardon Jack A Taylor M Dawn Teare Manuel R Teixeira Mary Beth Terry Kathryn L Terry Stephen N Thibodeau Mads Thomassen Line Bjørge Marc Tischkowitz Amanda E Toland Diana Torres Paul A Townsend Ruth C Travis Nadine Tung Shelley S Tworoger Cornelia M Ulrich Nawaid Usmani Celine M Vachon Els Van Nieuwenhuysen Ana Vega Miguel Elías Aguado-Barrera Qin Wang Penelope M Webb Clarice R Weinberg Stephanie Weinstein Mark C Weissler Jeffrey N Weitzel Catharine M L West Emily White Alice S Whittemore H-Erich Wichmann Fredrik Wiklund Robert Winqvist Alicja Wolk Penella Woll Michael Woods Anna H Wu Xifeng Wu Drakoulis Yannoukakos Wei Zheng Shanbeh Zienolddiny Argyrios Ziogas Kristin K Zorn Jacqueline M Lane Richa Saxena Duncan Thomas Rayjean J Hung Brenda Diergaarde James McKay Ulrike Peters Li Hsu Montserrat García-Closas Rosalind A Eeles Georgia Chenevix-Trench Paul J Brennan Christopher A Haiman Jacques Simard Douglas F Easton Stephen B Gruber Paul D P Pharoah Alkes L Price Bogdan Pasaniuc Christopher I Amos Peter Kraft Sara Lindström

Nat Commun 2019 01 25;10(1):431. Epub 2019 Jan 25.

Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., Seattle, WA, 98109-1024, USA.

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http://dx.doi.org/10.1038/s41467-018-08054-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347624PMC
January 2019

Impact of primary tumour location on efficacy of bevacizumab plus chemotherapy in metastatic colorectal cancer.

Br J Cancer 2018 12 29;119(12):1451-1455. Epub 2018 Nov 29.

University of Southern California, Norris Comprehensive Cancer Center, Keck School of Medicine, 1441 Eastlake Ave, Los Angeles, CA, 90033, USA.

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http://www.nature.com/articles/s41416-018-0304-6
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http://dx.doi.org/10.1038/s41416-018-0304-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288128PMC
December 2018

LONG-NONCODING RNAs in gastroesophageal cancers.

Noncoding RNA Res 2018 Dec 1;3(4):195-212. Epub 2018 Nov 1.

Department of Medicine (DIMED), Surgical Pathology & Cytopathology Unit, University of Padua, Padua, PD, Italy.

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http://dx.doi.org/10.1016/j.ncrna.2018.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257886PMC
December 2018

Noninferiority of three months versus six months of oxaliplatin-based adjuvant chemotherapy for resected colon cancer. How should IDEA findings affect clinical practice?

Int J Cancer 2018 11 11;143(10):2342-2350. Epub 2018 Aug 11.

Medical Oncology Unit, Department of Systems Medicine, Tor Vergata University Hospital, Rome, Italy.

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http://dx.doi.org/10.1002/ijc.31616DOI Listing
November 2018

Cancer Immunotherapy and Identification of Prognostic and Predictive Biomarkers.

Biomed Res Int 2018;2018:5184075. Epub 2018 Mar 20.

Medical Oncology Unit 1, Clinical and Experimental Oncology Department, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy.

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http://dx.doi.org/10.1155/2018/5184075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884437PMC
October 2018

Pharmacokinetic analysis of metronomic capecitabine in refractory metastatic colorectal cancer patients.

Invest New Drugs 2018 08 27;36(4):709-714. Epub 2018 Feb 27.

Divisione di Farmacologia, Dipartimento di Medicina Clinica e Sperimentale, Università di Pisa, Pisa, Italy.

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http://dx.doi.org/10.1007/s10637-018-0579-8DOI Listing
August 2018

Loss of Chromosome 18q11.2-q12.1 Is Predictive for Survival in Patients With Metastatic Colorectal Cancer Treated With Bevacizumab.

J Clin Oncol 2018 07 24;36(20):2052-2060. Epub 2018 May 24.

Erik van Dijk, Hedde D. Biesma, Martijn Cordes, Maarten Neerincx, Paul P. Eijk, Henk M.W. Verheul, Nicole C.T. van Grieken, and Bauke Ylstra, Vrije Universiteit Medical Center; Gerrit A. Meijer, Netherlands Cancer Institute; Cornelis J.A. Punt, Academic Medical Center, Amsterdam; Miriam Koopman, University Medical Center Utrecht, Utrecht, the Netherlands; Dominiek Smeets and Diether Lambrechts, KU Leuven, Leuven, Belgium; Sudipto Das, Orna Bacon, Jochen H.M. Prehn, Bryan T. Hennessey, Darran P. O'Connor, and Annette T. Byrne, Royal College of Surgeons in Ireland; Verena Murphy, Cancer Trials Ireland; Anna Barat, Deborah A. McNamara, and Elaine W. Kay, Beaumont Hospital; Bozena Fender and William M. Gallagher, OncoMark Ltd; Rut Klinger and William M. Gallagher, University College Dublin, Dublin, United Kingdom; Johannes Betge, Timo Gaiser, and Matthias P.A. Ebert, University Hospital Mannheim, Mannheim, Germany; and Fotios Loupakis, Veneto Institute of Oncology IOV-IRCCS Padua, Italy.

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http://dx.doi.org/10.1200/JCO.2017.77.1782DOI Listing
July 2018

Precision medicine in cholangiocarcinoma.

Transl Gastroenterol Hepatol 2018 12;3:40. Epub 2018 Jul 12.

Department of Molecular Medicine (DMM), University of Padua, Padua, Italy.

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http://tgh.amegroups.com/article/view/4380/5166
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http://dx.doi.org/10.21037/tgh.2018.07.02DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6087799PMC
July 2018

The role of tumor angiogenesis as a therapeutic target in colorectal cancer.

Expert Rev Anticancer Ther 2018 03 19;18(3):251-266. Epub 2018 Jan 19.

a Medical Oncology Unit 1, Clinical and Experimental Oncology Department , Veneto Institute of Oncology IOV-IRCCS , Padua , Italy.

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https://www.tandfonline.com/doi/full/10.1080/14737140.2018.1
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http://dx.doi.org/10.1080/14737140.2018.1428092DOI Listing
March 2018

Potential role of polymorphisms in the transporter genes ENT1 and MATE1/OCT2 in predicting TAS-102 efficacy and toxicity in patients with refractory metastatic colorectal cancer.

Eur J Cancer 2017 11 6;86:197-206. Epub 2017 Oct 6.

Division of Medical Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90033, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2017.08.033DOI Listing
November 2017

Anti-EGFR monoclonal antibody panitumumab for the treatment of patients with metastatic colorectal cancer: an overview of current practice and future perspectives.

Expert Opin Biol Ther 2017 10 28;17(10):1297-1308. Epub 2017 Jul 28.

a Clinical and Experimental Oncology Department, Medical Oncology Unit 1 , Veneto Institute of Oncology IOV - IRCCS , Padova , Italy.

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https://www.tandfonline.com/doi/full/10.1080/14712598.2017.1
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http://dx.doi.org/10.1080/14712598.2017.1356815DOI Listing
October 2017

New perspectives for TAS-102: TASK successful?

Lancet Oncol 2017 09 28;18(9):1139-1141. Epub 2017 Jul 28.

Unit of Medical Oncology 1, Department of Clinical and Experimental Oncology, Istituto Oncologico Veneto, IRCCS, 35128 Padua, Italy.

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http://dx.doi.org/10.1016/S1470-2045(17)30574-0DOI Listing
September 2017

Homeobox B9 Mediates Resistance to Anti-VEGF Therapy in Colorectal Cancer Patients.

Clin Cancer Res 2017 Aug 15;23(15):4312-4322. Epub 2017 Mar 15.

Digestive Molecular Clinical Oncology Research Unit, Department of Medicine, Università degli studi di Verona, Verona, Italy.

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http://dx.doi.org/10.1158/1078-0432.CCR-16-3153DOI Listing
August 2017

Autophagy-related polymorphisms predict hypertension in patients with metastatic colorectal cancer treated with FOLFIRI and bevacizumab: Results from TRIBE and FIRE-3 trials.

Eur J Cancer 2017 05 26;77:13-20. Epub 2017 Mar 26.

Division of Medical Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90033, USA; Department of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90033, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2017.02.020DOI Listing
May 2017

The role of pharmacogenetics in the new ESMO colorectal cancer guidelines.

Pharmacogenomics 2017 02 23;18(3):197-200. Epub 2017 Jan 23.

Oncologia Medica 1, Istituto Oncologico Veneto, IRCCS Padova, Italy.

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http://dx.doi.org/10.2217/pgs-2016-0191DOI Listing
February 2017

Topoisomerase 1 Promoter Variants and Benefit from Irinotecan in Metastatic Colorectal Cancer Patients.

Oncology 2016 31;91(5):283-288. Epub 2016 Aug 31.

Unit of Clinical Pharmacology and Pharmacogenetics, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

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http://dx.doi.org/10.1159/000448004DOI Listing
January 2017

Prognostic Impact of IL6 Genetic Variants in Patients with Metastatic Colorectal Cancer Treated with Bevacizumab-Based Chemotherapy.

Clin Cancer Res 2016 07 2;22(13):3218-26. Epub 2016 Feb 2.

Division of Medical Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-2422DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930688PMC
July 2016

TAS-102 for the treatment of metastatic colorectal cancer.

Expert Rev Anticancer Ther 2015 28;15(11):1283-92. Epub 2015 Oct 28.

a Division of Medical Oncology , Azienda Ospedaliero-Universitaria Pisana, Istituto Toscano Tumori , Pisa , Italy.

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http://dx.doi.org/10.1586/14737140.2015.1105746DOI Listing
June 2016

CDX2 as a Prognostic Biomarker in Colon Cancer.

N Engl J Med 2016 06;374(22):2183

University of Southern California, Los Angeles, Los Angeles, CA

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http://dx.doi.org/10.1056/NEJMc1602584DOI Listing
June 2016

Body Mass Index Is Prognostic in Metastatic Colorectal Cancer: Pooled Analysis of Patients From First-Line Clinical Trials in the ARCAD Database.

J Clin Oncol 2016 Jan 26;34(2):144-50. Epub 2015 Oct 26.

Lindsay A. Renfro and Daniel J. Sargent, Mayo Clinic, Rochester, MN; Fotios Loupakis and Alfredo Falcone, Azienda Ospedaliero-Universitaria Pisana and Università di Pisa, Pisa, Italy; Richard Adams, Cardiff University, Cardiff; Matthew T. Seymour, St James's Hospital and University of Leeds, Leeds, United Kingdom; Volker Heinemann, University of Munich, Munich; Hans-Joachim Schmoll, University Clinic Halle (Saale), Halle; Rainer Porschen, Klinikum Bremen-Ost Klinik für Innere Medizin, Bremen; Carsten Bokemeyer, University Hospital Cancer Center, University Hospital, Hamburg-Eppendorf, Germany; Jean-Yves Douillard, Institut de Cancerologie, Centre René Gauducheau, Nantes; Christophe Tournigand, University of Paris Est Creteil, Henri-Mondor Hospital, Créteil; Benoist Chibaudel and Aimery de Gramont, Franco-British Institute, Levallois-Perret, France; Herbert Hurwitz, Duke University Medical Center, Durham, NC; Charles S. Fuchs, Dana-Farber Cancer Institute Boston, MA; Eduardo Diaz-Rubio, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos, Madrid, Spain; Niall C. Tebbutt, Austin Health, Heidelberg, Victoria, Australia; Cornelis J.A. Punt, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands; J. Randolph Hecht, David Geffen School of Medicine at the University of California at Los Angeles; Heinz-Josef Lenz, University of Southern California/Norris Comprehensive Cancer Center, Keck School of Medicine, Los Angeles, CA; Eric Van Cutsem, University Hospital Leuven, Leuven, Belgium; Richard M. Goldberg, Ohio State University, Columbus, OH; and Leonard B. Saltz, Memorial Sloan-Kettering Cancer Center, New York, NY.

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http://dx.doi.org/10.1200/JCO.2015.61.6441DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5070548PMC
January 2016

BRAF-mutated metastatic colorectal cancer between past and future.

Br J Cancer 2015 Dec 10;113(11):1634-5. Epub 2015 Sep 10.

Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

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http://dx.doi.org/10.1038/bjc.2015.316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705874PMC
December 2015

TRIBE study: are all three cytotoxic drugs crucial? - Authors' reply.

Lancet Oncol 2015 Dec;16(16):e578-9

Polo Oncologico, Azienda Ospedaliero-Universitaria Pisana, Via Roma 67, 56126 Pisa, Italy; Dipartimento di Ricerca Traslazionale e delle Nuove Tecnologie in Medicina, Università di Pisa, Pisa, Italy. Electronic address:

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http://dx.doi.org/10.1016/S1470-2045(15)00416-7DOI Listing
December 2015

TAS-102, a novel antitumor agent: a review of the mechanism of action.

Cancer Treat Rev 2015 Nov 6;41(9):777-83. Epub 2015 Jun 6.

Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana, Istituto Toscano Tumori, Via Taddeo Alderotti 26/N, 50139 Firenze, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ctrv.2015.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624296PMC
November 2015

First-line anti-EGFR monoclonal antibodies in panRAS wild-type metastatic colorectal cancer: A systematic review and meta-analysis.

Crit Rev Oncol Hematol 2015 Oct 5;96(1):156-66. Epub 2015 Jun 5.

Fondazione IRCCS Istituto Nazionale dei Tumori, Medical Oncology Unit, Milan, Italy; Department of Radiology, Oncology and Human-Pathology, Sapienza University of Rome, Rome, Italy.

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http://dx.doi.org/10.1016/j.critrevonc.2015.05.016DOI Listing
October 2015

Polymorphisms in Genes Involved in EGFR Turnover Are Predictive for Cetuximab Efficacy in Colorectal Cancer.

Mol Cancer Ther 2015 Oct 23;14(10):2374-81. Epub 2015 Jul 23.

USC/Norris Comprehensive Cancer Center, Keck School of Medicine, Sharon Carpenter Laboatory, Los Angeles, California. Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.

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http://dx.doi.org/10.1158/1535-7163.MCT-15-0121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596768PMC
October 2015

First-line chemotherapy for mCRC—a review and evidence-based algorithm.

Nat Rev Clin Oncol 2015 Oct 28;12(10):607-19. Epub 2015 Jul 28.

Unit of Medical Oncology 2, Azienda Ospedaliera-Universitaria Pisana, Via Roma 67, 56126 Pisa, Italy.

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http://dx.doi.org/10.1038/nrclinonc.2015.129DOI Listing
October 2015

Primary tumor location as a prognostic factor in metastatic colorectal cancer.

J Natl Cancer Inst 2015 Mar 24;107(3). Epub 2015 Feb 24.

University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA (FL, DY, WZ, HJL); U.O. Oncologia Medica, Azienda Ospedaliero-Universitaria Pisana, Istituto Toscano Tumori, Pisa, Italy (FL, CC, CA, AF); Genentech, Inc., South San Francisco, CA (LY, SF, CL, SJS, TM); Department of General, Visceral, and Tumor Surgery, University of Cologne, Cologne, Germany (MKHM); Response Genetics, Inc., Los Angeles, CA (MKHM); Department of Medical Oncology and Transplantation, Duke University, Durham, NC (HIH); Memorial Sloan-Kettering Cancer Center, New York, NY (LS) Current Affiliations: Onyx Pharmaceuticals, Inc. South San Francisco, CA (SF); Biocenter, Physiological Chemistry 1, University of Wuerzburg, Wuerzburg, Germany (SJS); Biomarker, Translational and Predictive Medicine Consulting, San Francisco, CA (TM).

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http://dx.doi.org/10.1093/jnci/dju427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4565528PMC
March 2015

Initial therapy with FOLFOXIRI and bevacizumab for metastatic colorectal cancer.

N Engl J Med 2014 Oct;371(17):1609-18

From Azienda Ospedaliero-Universitaria Pisana and Università di Pisa, Pisa (F.L., C. Cremolini, G.M., L.S., A.F.), Istituto Oncologico Veneto, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Padua (S.L., V.Z.), Sapienza Università di Roma (E.C.) and Università Campus Biomedico (G. Tonini), Rome, Azienda Istituti Ospitalieri, Cremona (G. Tomasello), Ospedale San Raffaele, IRCCS, Milan (M.R.), Azienda Ospedaliero-Universitaria Città della Salute e della Scienza, Turin (R.S.), Fondazione Poliambulanza, Brescia (A.Z.), Centro di Riferimento Oncologico, IRCCS, Aviano (A.B.), Ospedale Versilia, Lido di Camaiore (D.A.), Ospedale San Martino, IRCCS, Genoa (S.C.), Azienda Ospedaliera Universitaria Federico II, Naples (C. Carlomagno), Arcispedale Santa Maria Nuova, IRCCS, Reggio Emilia (C.B.), Ospedale Felice Lotti, Pontedera (G.A.), and Azienda Ospedaliero-Universitaria Careggi and Istituto Toscano Tumori, Florence (L.B.) - all in Italy.

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http://dx.doi.org/10.1056/NEJMoa1403108DOI Listing
October 2014

Biomarkers and response to bevacizumab--letter.

Clin Cancer Res 2014 Feb;20(4):1056-7

Authors' Affiliations: Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana; Division of Pharmacology, Department of Clinical and Experimental Medicine; Division of Medical Oncology, Department of Translational Research, University of Pisa, Pisa; and Istituto Toscano Tumori, Firenze, Italy.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-2763DOI Listing
February 2014

A perspective on the current management of advanced colorectal cancer.

Future Oncol 2013 Nov;9(11):1687-91

Department of Oncology, University & General Hospital, Udine, Italy.

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http://dx.doi.org/10.2217/fon.13.189DOI Listing
November 2013

Prognostic role of lemur tyrosine kinase-3 germline polymorphisms in adjuvant gastric cancer in Japan and the United States.

Mol Cancer Ther 2013 Oct 5;12(10):2261-72. Epub 2013 Aug 5.

Corresponding Author: Heinz-Josef Lenz, Sharon A. Carpenter Laboratory, Division of Medical Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, 1441 Eastlake Avenue, Los Angeles, CA 90033.

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http://mct.aacrjournals.org/cgi/doi/10.1158/1535-7163.MCT-12
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http://dx.doi.org/10.1158/1535-7163.MCT-12-1134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810398PMC
October 2013

Adjuvant systemic chemotherapy after putative curative resection of colorectal liver and lung metastases.

Clin Colorectal Cancer 2013 Sep 14;12(3):188-94. Epub 2013 Jun 14.

Seràgnoli Department of Hematology and Oncological Sciences, University of Bologna, S.Orsola-Malpighi Hospital, Bologna, Italy.

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http://dx.doi.org/10.1016/j.clcc.2013.04.002DOI Listing
September 2013

Liquid biopsy: monitoring cancer-genetics in the blood.

Nat Rev Clin Oncol 2013 Aug 9;10(8):472-84. Epub 2013 Jul 9.

Department of Oncology, University of Turin, Institute for Cancer Research and Treatment, Strada Provinciale 142 Km 3.95, 10060 Candiolo, Turin, Italy.

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http://dx.doi.org/10.1038/nrclinonc.2013.110DOI Listing
August 2013

Caveolin-1 is a novel regulator of K-RAS-dependent migration in colon carcinogenesis.

Int J Cancer 2013 Jul 12;133(1):43-57. Epub 2013 Feb 12.

Department of Biochemistry and Molecular Biophysics, Biochemistry and Molecular and Cellular Biology Graduate Program, University of Arizona, Tucson, AZ, USA.

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http://dx.doi.org/10.1002/ijc.28001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3633716PMC
July 2013