Fons A Loo

Fons A van de Loo

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Fons A Loo

Fons A van de Loo

Publications by authors named "Fons A van de Loo"

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1PubMed Central Citations

Protective Role of the MER Tyrosine Kinase Efferocytosis in Rheumatoid Arthritis Models.

Front Immunol 2018 13;9:742. Epub 2018 Apr 13.

Experimental Rheumatology, Department of Rheumatology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands.

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http://dx.doi.org/10.3389/fimmu.2018.00742DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908888PMC
June 2019

A three-dimensional model to study human synovial pathology.

ALTEX 2019 9;36(1):18-28. Epub 2018 Oct 9.

Experimental Rheumatology, Department of Rheumatology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.

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https://www.altex.org/index.php/altex/article/view/827
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http://dx.doi.org/10.14573/altex.1804161DOI Listing
April 2019

Tyro3/Axl/Mertk-deficient mice develop bone marrow edema which is an early pathological marker in rheumatoid arthritis.

PLoS One 2018 18;13(10):e0205902. Epub 2018 Oct 18.

Experimental Rheumatology, Department of Rheumatology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0205902PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193696PMC
March 2019

The level of synovial AXL expression determines the outcome of inflammatory arthritis, possibly depending on the upstream role of TGF-β1.

Rheumatology (Oxford) 2019 Mar;58(3):536-546

Experimental Rheumatology, Department of Rheumatology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.

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http://dx.doi.org/10.1093/rheumatology/key337DOI Listing
March 2019

Interleukin 1 β-induced SMAD2/3 linker modifications are TAK1 dependent and delay TGFβ signaling in primary human mesenchymal stem cells.

Cell Signal 2017 12 21;40:190-199. Epub 2017 Sep 21.

Radboud University Medical Center, Department of Rheumatology, Experimental Rheumatology, PO Box 9101, 6500 HB Nijmegen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.cellsig.2017.09.010DOI Listing
December 2017

Transcriptional profiling distinguishes inner and outer annulus fibrosus from nucleus pulposus in the bovine intervertebral disc.

Eur Spine J 2017 08 31;26(8):2053-2062. Epub 2017 May 31.

Department of Rheumatology, Radboud University Medical Center, PO Box 9101, 6500 HB, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1007/s00586-017-5150-3DOI Listing
August 2017

Functional Tissue Analysis Reveals Successful Cryopreservation of Human Osteoarthritic Synovium.

PLoS One 2016 21;11(11):e0167076. Epub 2016 Nov 21.

Experimental Rheumatology, Department of Rheumatology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0167076PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5117761PMC
June 2017

Milk-Derived Nanoparticle Fraction Promotes the Formation of Small Osteoclasts But Reduces Bone Resorption.

J Cell Physiol 2017 01 2;232(1):225-33. Epub 2016 Jun 2.

Experimental Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1002/jcp.25414DOI Listing
January 2017

Two opposite extremes of adiposity similarly reduce inflammatory response of antigen-induced acute joint inflammation.

Nutrition 2017 Jan 5;33:132-140. Epub 2016 Jun 5.

Nutrition Department, Nursing School, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil; Immunopharmacology, Department of Biochemistry and Immunology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. Electronic address:

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http://dx.doi.org/10.1016/j.nut.2016.05.008DOI Listing
January 2017

Alarmin S100A9 Induces Proinflammatory and Catabolic Effects Predominantly in the M1 Macrophages of Human Osteoarthritic Synovium.

J Rheumatol 2016 10 1;43(10):1874-1884. Epub 2016 Aug 1.

From Experimental Rheumatology, Radboud University Medical Center, Nijmegen, the Netherlands; Institute of Immunology, University of Münster, Münster, Germany.M.H. van den Bosch, MSc, Experimental Rheumatology, Radboud University Medical Center; A.B. Blom, PhD, Experimental Rheumatology, Radboud University Medical Center; R.F. Schelbergen, PhD, Experimental Rheumatology, Radboud University Medical Center; M.I. Koenders, PhD, Experimental Rheumatology, Radboud University Medical Center; F.A. van de Loo, PhD, Experimental Rheumatology, Radboud University Medical Center; W.B. van den Berg, PhD, Professor, Experimental Rheumatology, Radboud University Medical Center; T. Vogl, PhD, Professor, Institute of Immunology, University of Muenster; J. Roth, PhD, Professor, Institute of Immunology, University of Münster; P.M. van der Kraan, PhD, Experimental Rheumatology, Radboud University Medical Center; P.L. van Lent, PhD, Experimental Rheumatology, Radboud University Medical Center.

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http://dx.doi.org/10.3899/jrheum.160270DOI Listing
October 2016

Suppression of the inflammatory response by disease-inducible interleukin-10 gene therapy in a three-dimensional micromass model of the human synovial membrane.

Arthritis Res Ther 2016 08 12;18:186. Epub 2016 Aug 12.

Experimental Rheumatology, Department of Rheumatology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, PO Box 9101, 6500 HB, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1186/s13075-016-1083-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4983024PMC
August 2016

Milk extracellular vesicles accelerate osteoblastogenesis but impair bone matrix formation.

J Nutr Biochem 2016 Apr 28;30:74-84. Epub 2015 Dec 28.

Experimental Rheumatology, Radboud University Medical Center, Nijmegen, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.jnutbio.2015.11.017DOI Listing
April 2016

Disease-regulated local IL-10 gene therapy diminishes synovitis and cartilage proteoglycan depletion in experimental arthritis.

Ann Rheum Dis 2015 Nov 15;74(11):2084-91. Epub 2014 Jul 15.

Experimental Rheumatology, Department of Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1136/annrheumdis-2014-205223DOI Listing
November 2015

Toll-like receptor 4 in bone marrow-derived cells as well as tissue-resident cells participate in aggravating autoimmune destructive arthritis.

Ann Rheum Dis 2013 Aug 3;72(8):1407-15. Epub 2013 Jan 3.

Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1136/annrheumdis-2012-202467DOI Listing
August 2013

Disease-dependent local IL-10 production ameliorates collagen induced arthritis in mice.

PLoS One 2012 16;7(11):e49731. Epub 2012 Nov 16.

Department of Rheumatology and Inflammation Research, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0049731PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500327PMC
June 2013

A pivotal role for antigen-presenting cells overexpressing SOCS3 in controlling invariant NKT cell responses during collagen-induced arthritis.

Ann Rheum Dis 2011 Dec 27;70(12):2167-75. Epub 2011 Aug 27.

Department of Rheumatology, Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, The Netherlands.

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http://dx.doi.org/10.1136/ard.2011.154815DOI Listing
December 2011

Toll-like receptor 4 signalling is specifically TGF-beta-activated kinase 1 independent in synovial fibroblasts.

Rheumatology (Oxford) 2011 Jul 18;50(7):1216-25. Epub 2011 Feb 18.

Department of Rheumatology, Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.1093/rheumatology/ker021DOI Listing
July 2011

A novel Saa3-promoter reporter distinguishes inflammatory subtypes in experimental arthritis and human synovial fibroblasts.

Ann Rheum Dis 2011 Jul 7;70(7):1311-9. Epub 2011 Apr 7.

Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, The Netherlands.

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http://dx.doi.org/10.1136/ard.2010.135665DOI Listing
July 2011

Abnormal actomyosin assembly in proliferating and differentiating myoblasts upon expression of a cytosolic DMPK isoform.

Biochim Biophys Acta 2011 May 2;1813(5):867-77. Epub 2011 Feb 2.

Department of Cell Biology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.bbamcr.2011.01.024DOI Listing
May 2011

Tumour necrosis factor alpha-driven IL-32 expression in rheumatoid arthritis synovial tissue amplifies an inflammatory cascade.

Ann Rheum Dis 2011 Apr 27;70(4):660-7. Epub 2010 Dec 27.

Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500HB, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1136/ard.2010.139196DOI Listing
April 2011

Inflammation-dependent secretion and splicing of IL-32{gamma} in rheumatoid arthritis.

Proc Natl Acad Sci U S A 2011 Mar 7;108(12):4962-7. Epub 2011 Mar 7.

Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, 6500 HB, Nijmegen, The Netherlands.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1016005108
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http://dx.doi.org/10.1073/pnas.1016005108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3064318PMC
March 2011

IL-32gamma and Streptococcus pyogenes cell wall fragments synergise for IL-1-dependent destructive arthritis via upregulation of TLR-2 and NOD2.

Ann Rheum Dis 2010 Oct 14;69(10):1866-72. Epub 2010 May 14.

Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500HB, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1136/ard.2009.127399DOI Listing
October 2010

A crucial role for tumor necrosis factor receptor 1 in synovial lining cells and the reticuloendothelial system in mediating experimental arthritis.

Arthritis Res Ther 2010 6;12(2):R61. Epub 2010 Apr 6.

Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, 6525 GA Nijmegen, The Netherlands.

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http://dx.doi.org/10.1186/ar2974DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2888212PMC
September 2010

Computational design and application of endogenous promoters for transcriptionally targeted gene therapy for rheumatoid arthritis.

Mol Ther 2009 Nov 18;17(11):1877-87. Epub 2009 Aug 18.

Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1038/mt.2009.182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835043PMC
November 2009

Local interleukin-1-driven joint pathology is dependent on toll-like receptor 4 activation.

Am J Pathol 2009 Nov 15;175(5):2004-13. Epub 2009 Oct 15.

Department of Rheumatology, Radboud University Nijmegen Medical Centre, The Netherlands.

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http://dx.doi.org/10.2353/ajpath.2009.090262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2774064PMC
November 2009

A tail-anchored myotonic dystrophy protein kinase isoform induces perinuclear clustering of mitochondria, autophagy, and apoptosis.

PLoS One 2009 Nov 25;4(11):e8024. Epub 2009 Nov 25.

Department of Cell Biology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0008024PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778554PMC
November 2009

Elevated extracellular matrix production and degradation upon bone morphogenetic protein-2 (BMP-2) stimulation point toward a role for BMP-2 in cartilage repair and remodeling.

Arthritis Res Ther 2007 ;9(5):R102

Experimental Rheumatology and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Geert Grooteplein 26-28, Nijmegen, 6500 HB, The Netherlands.

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http://dx.doi.org/10.1186/ar2305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212581PMC
April 2008

Gene therapy works in animal models of rheumatoid arthritis...so what!

Curr Rheumatol Rep 2006 Oct;8(5):386-93

Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Geert Grooteplein 28, 6525 GA Nijmegen, The Netherlands.

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October 2006

Interleukin-17 acts independently of TNF-alpha under arthritic conditions.

J Immunol 2006 May;176(10):6262-9

Experimental Rheumatology and Advanced Therapeutics, Radboud University Nijmegen Medical Center, PO Box 9101, 6500 HB Nijmegen, the Netherlands.

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http://dx.doi.org/10.4049/jimmunol.176.10.6262DOI Listing
May 2006

IL-32, a proinflammatory cytokine in rheumatoid arthritis.

Proc Natl Acad Sci U S A 2006 Feb 21;103(9):3298-303. Epub 2006 Feb 21.

Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, The Netherlands.

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http://dx.doi.org/10.1073/pnas.0511233103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1413916PMC
February 2006

Gene therapy in animal models of rheumatoid arthritis: are we ready for the patients?

Arthritis Res Ther 2004 29;6(5):183-96. Epub 2004 Jul 29.

Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, University Medical Center Nijmegen, Nijmegen Center for Molecular Life Sciences, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1186/ar1214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC546285PMC
October 2005

Male IL-6 gene knock out mice developed more advanced osteoarthritis upon aging.

Osteoarthritis Cartilage 2005 Jan;13(1):66-73

Rheumatology Research Laboratory, University Medical Center Nijmegen, Nijmegen Center for Molecular Life Sciences, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.joca.2004.09.011DOI Listing
January 2005

Inflammation-responsive promoters for fine-tuned gene therapy in rheumatoid arthritis.

Curr Opin Mol Ther 2004 Oct;6(5):537-45

University Medical Center Nijmegen, Nijmegen Center for Molecular Life Sciences, Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Geert Grooteplein 26-28, 6500 HB Nijmegen, The Netherlands.

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October 2004

Role of gene therapy in tissue engineering procedures in rheumatology: the use of animal models.

Biomaterials 2004 Apr;25(9):1497-504

Experimental Rheumatology and Advanced Therapeutics, Nijmegen Center for Molecular Life Sciences, University Medical Center Nijmegen, Geert Grooteplein 26-28, GA 6525, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/s0142-9612(03)00493-9DOI Listing
April 2004

Inducible nitric oxide synthase mediates bone loss in ovariectomized mice.

Endocrinology 2003 Mar;144(3):1098-107

Institute of Pharmacology, School of Medicine, University of Messina, 98100 Messina, Italy.

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http://dx.doi.org/10.1210/en.2002-220597DOI Listing
March 2003

Gene therapy for rheumatoid arthritis. Lessons from animal models, including studies on interleukin-4, interleukin-10, and interleukin-1 receptor antagonist as potential disease modulators.

Rheum Dis Clin North Am 2002 Feb;28(1):127-49

Department of Rheumatology, University Medical Center Nijmegen, Nijmegen, The Netherlands.

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February 2002