Folkert W Asselbergs

Folkert W Asselbergs

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Folkert W Asselbergs

Folkert W Asselbergs

Publications by authors named "Folkert W Asselbergs"

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Predicting sustained ventricular arrhythmias in dilated cardiomyopathy: a meta-analysis and systematic review.

ESC Heart Fail 2020 Aug 14;7(4):1430-1441. Epub 2020 Apr 14.

Department of Cardiology, Division Heart & Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

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http://dx.doi.org/10.1002/ehf2.12689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7373946PMC
August 2020

Cardiovascular adverse events following treatment for non-Hodgkin lymphoma - Authors' reply.

Lancet Haematol 2020 Aug;7(8):e557-e558

Department of Cardiology, Division of Heart and Lungs, University Medical Centre Utrecht, University of Utrecht, Utrecht 85500, Netherlands; Institute of Cardiovascular Science, Faculty of Population Health Sciences, and Health Data Research UK, and Institute of Health Informatics, University College London, London, UK.

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http://dx.doi.org/10.1016/S2352-3026(20)30228-3DOI Listing
August 2020

Association of Factor V Leiden with Subsequent Atherothrombotic Events: A GENIUS-CHD Study of Individual Participant Data.

Circulation 2020 Jul 13. Epub 2020 Jul 13.

Institute of Cardiovascular Science and UCL BHF Research Accelerator, Faculty of Population Health Science, University College London, London, UK; Bart's Heart Centre, St Bartholomew's Hospital, London, EC1A2DA, UK.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.119.045526DOI Listing
July 2020

Carotid Intima-Media Thickness Progression as Surrogate Marker for Cardiovascular Risk: Meta-Analysis of 119 Clinical Trials Involving 100,667 Patients.

Circulation 2020 Jun 17. Epub 2020 Jun 17.

Department of Neurology, Goethe University, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.120.046361DOI Listing
June 2020

A registry-based algorithm to predict ejection fraction in patients with heart failure.

ESC Heart Fail 2020 Jun 17. Epub 2020 Jun 17.

Division of Cardiology, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1002/ehf2.12779DOI Listing
June 2020

Genetic drug target validation using Mendelian randomisation.

Nat Commun 2020 Jun 26;11(1):3255. Epub 2020 Jun 26.

Institute of Cardiovascular Science, Faculty of Population Health, University College London, London, WC1E 6BT, UK.

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http://dx.doi.org/10.1038/s41467-020-16969-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320010PMC
June 2020

Polygenic risk scores for coronary artery disease and subsequent event risk amongst established cases.

Hum Mol Genet 2020 May;29(8):1388-1395

Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, London NW1 2DA, UK.

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http://dx.doi.org/10.1093/hmg/ddaa052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254844PMC
May 2020

CAPACITY-COVID: a European Registry to determine the role of cardiovascular disease in the COVID-19 pandemic.

Eur Heart J 2020 05;41(19):1795-1796

Department of Cardiology, Division of Heart and Lungs, University Medical Centre Utrecht, Utrecht, the Netherlands.

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http://dx.doi.org/10.1093/eurheartj/ehaa280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184392PMC
May 2020

Family history and polygenic risk of cardiovascular disease: Independent factors associated with secondary cardiovascular events in patients undergoing carotid endarterectomy.

Atherosclerosis 2020 May 3. Epub 2020 May 3.

Laboratory of Clinical Chemistry and Hematology, Division Laboratories and Pharmacy, University Medical Centre Utrecht, Utrecht University, Utrecht, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2020.04.013DOI Listing
May 2020

Cardiovascular adverse events in patients with non-Hodgkin lymphoma treated with first-line cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) or CHOP with rituximab (R-CHOP): a systematic review and meta-analysis.

Lancet Haematol 2020 Apr 2;7(4):e295-e308. Epub 2020 Mar 2.

Department of Cardiology, Division of Heart and Lungs, University Medical Centre Utrecht, University of Utrecht, Utrecht, Netherlands; Netherlands Heart Institute, Utrecht, Netherlands; Health Data Research UK, Institute of Health Informatics and Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, London, UK.

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http://dx.doi.org/10.1016/S2352-3026(20)30031-4DOI Listing
April 2020

Low-Density Lipoprotein Cholesterol Target Attainment in Patients With Established Cardiovascular Disease: Analysis of Routine Care Data.

JMIR Med Inform 2020 Apr 2;8(4):e16400. Epub 2020 Apr 2.

Laboratory of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.

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http://dx.doi.org/10.2196/16400DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7163416PMC
April 2020

Model selection for metabolomics: predicting diagnosis of coronary artery disease using automated machine learning.

Bioinformatics 2020 Mar;36(6):1772-1778

Department of Biostatistics, Epidemiology and Informatics, Institute for Biomedical Informatics, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1093/bioinformatics/btz796DOI Listing
March 2020

Data mining information from electronic health records produced high yield and accuracy for current smoking status.

J Clin Epidemiol 2020 Feb 12;118:100-106. Epub 2019 Nov 12.

Laboratory of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

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http://dx.doi.org/10.1016/j.jclinepi.2019.11.006DOI Listing
February 2020

Age at menarche and heart failure risk: The EPIC-NL study.

Maturitas 2020 Jan 5;131:34-39. Epub 2019 Nov 5.

Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.maturitas.2019.10.003DOI Listing
January 2020

Adherence to the Dutch dietary guidelines and 15-year incidence of heart failure in the EPIC-NL cohort.

Eur J Nutr 2020 Jan 7. Epub 2020 Jan 7.

Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

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http://dx.doi.org/10.1007/s00394-019-02170-7DOI Listing
January 2020

Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure.

Authors:
Sonia Shah Albert Henry Carolina Roselli Honghuang Lin Garðar Sveinbjörnsson Ghazaleh Fatemifar Åsa K Hedman Jemma B Wilk Michael P Morley Mark D Chaffin Anna Helgadottir Niek Verweij Abbas Dehghan Peter Almgren Charlotte Andersson Krishna G Aragam Johan Ärnlöv Joshua D Backman Mary L Biggs Heather L Bloom Jeffrey Brandimarto Michael R Brown Leonard Buckbinder David J Carey Daniel I Chasman Xing Chen Xu Chen Jonathan Chung William Chutkow James P Cook Graciela E Delgado Spiros Denaxas Alexander S Doney Marcus Dörr Samuel C Dudley Michael E Dunn Gunnar Engström Tõnu Esko Stephan B Felix Chris Finan Ian Ford Mohsen Ghanbari Sahar Ghasemi Vilmantas Giedraitis Franco Giulianini John S Gottdiener Stefan Gross Daníel F Guðbjartsson Rebecca Gutmann Christopher M Haggerty Pim van der Harst Craig L Hyde Erik Ingelsson J Wouter Jukema Maryam Kavousi Kay-Tee Khaw Marcus E Kleber Lars Køber Andrea Koekemoer Claudia Langenberg Lars Lind Cecilia M Lindgren Barry London Luca A Lotta Ruth C Lovering Jian'an Luan Patrik Magnusson Anubha Mahajan Kenneth B Margulies Winfried März Olle Melander Ify R Mordi Thomas Morgan Andrew D Morris Andrew P Morris Alanna C Morrison Michael W Nagle Christopher P Nelson Alexander Niessner Teemu Niiranen Michelle L O'Donoghue Anjali T Owens Colin N A Palmer Helen M Parry Markus Perola Eliana Portilla-Fernandez Bruce M Psaty Kenneth M Rice Paul M Ridker Simon P R Romaine Jerome I Rotter Perttu Salo Veikko Salomaa Jessica van Setten Alaa A Shalaby Diane T Smelser Nicholas L Smith Steen Stender David J Stott Per Svensson Mari-Liis Tammesoo Kent D Taylor Maris Teder-Laving Alexander Teumer Guðmundur Thorgeirsson Unnur Thorsteinsdottir Christian Torp-Pedersen Stella Trompet Benoit Tyl Andre G Uitterlinden Abirami Veluchamy Uwe Völker Adriaan A Voors Xiaosong Wang Nicholas J Wareham Dawn Waterworth Peter E Weeke Raul Weiss Kerri L Wiggins Heming Xing Laura M Yerges-Armstrong Bing Yu Faiez Zannad Jing Hua Zhao Harry Hemingway Nilesh J Samani John J V McMurray Jian Yang Peter M Visscher Christopher Newton-Cheh Anders Malarstig Hilma Holm Steven A Lubitz Naveed Sattar Michael V Holmes Thomas P Cappola Folkert W Asselbergs Aroon D Hingorani Karoline Kuchenbaecker Patrick T Ellinor Chim C Lang Kari Stefansson J Gustav Smith Ramachandran S Vasan Daniel I Swerdlow R Thomas Lumbers

Nat Commun 2020 01 9;11(1):163. Epub 2020 Jan 9.

British Heart Foundation Research Accelerator, University College London, London, UK.

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http://dx.doi.org/10.1038/s41467-019-13690-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952380PMC
January 2020

Beyond GWAS in Atrial Fibrillation Genetics.

Circ Res 2020 01 30;126(3):361-363. Epub 2020 Jan 30.

Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, the Netherlands (F.W.A.); and Institute of Cardiovascular Science and Health Informatics, Faculty of Population Health Sciences, University College London, United Kingdom.

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http://dx.doi.org/10.1161/CIRCRESAHA.119.316479DOI Listing
January 2020

Risk factors for incident heart failure in age- and sex-specific strata: a population-based cohort using linked electronic health records.

Eur J Heart Fail 2019 10 7;21(10):1197-1206. Epub 2019 Jan 7.

Farr Institute of Health Informatics Research, Institute of Health Informatics, University College London, London, UK.

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http://doi.wiley.com/10.1002/ejhf.1350
Publisher Site
http://dx.doi.org/10.1002/ejhf.1350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7074015PMC
October 2019

Temporal evolution of myeloperoxidase and galectin 3 during 1 year after acute coronary syndrome admission.

Am Heart J 2019 10 6;216:143-146. Epub 2019 Apr 6.

Erasmus MC, University Medical Center Rotterdam, Thoraxcenter, Department of Cardiology, Rotterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ahj.2019.02.016DOI Listing
October 2019

A Genotype-Guided Strategy for Oral P2Y Inhibitors in Primary PCI.

N Engl J Med 2019 10 3;381(17):1621-1631. Epub 2019 Sep 3.

From the Department of Cardiology, St. Antonius Hospital, Nieuwegein (D.M.F.C., G.J.A.V., T.O.B., P.W.A.J., J.C.K., J.M.B.), the Department of Cardiology, Isala Hospital, Zwolle (R.S.H., A.W.J.H.), the Department of Cardiology, University Medical Center Maastricht, Maastricht (A.W.J.H.), the Department of Cardiology, Zuyderland Medical Center, Heerlen (A.W.J.H.), the Department of Cardiology, University Medical Center Groningen (P.H., J.M.B.), the Department of Pharmacy, University of Groningen (M.J.P.), and the Unit of Global Health, Department of Health Sciences, University of Groningen, University Medical Center Groningen (M.J.P., C.B.), Groningen, the Department of Cardiology, Rijnstate Hospital, Arnhem (R.M.T.J.G.), the Department of Cardiology, Division of Heart and Lungs (F.W.A.), and the Department of Clinical Pharmacy, Division of Laboratories, Pharmacy, and Biomedical Genetics (V.H.M.D.), University Medical Center Utrecht, and the Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences (A.B.), Utrecht University, Utrecht, the Department of Cardiology, Meander Medical Center, Amersfoort (A.M.), the Department of Cardiology, Onze Lieve Vrouwe Gasthuis, Amsterdam (J.-P.R.H.), and the Department of Cardiology, Amphia Hospital, Breda (W.J.M.D.) - all in the Netherlands; the Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy (E.B., C.M.); the Cardiovascular Research Center, Onze Lieve Vrouwe Hospital, Aalst (E.B.), and the Department of Cardiology, Imelda Hospital, Bonheiden (W.J.M.D.) - both in Belgium; and the Institute of Cardiovascular Science, Faculty of Population Health Sciences, and Health Data Research UK and Institute of Health Informatics, University College London, London (F.W.A.).

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http://dx.doi.org/10.1056/NEJMoa1907096DOI Listing
October 2019

Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9.

Authors:
Amand F Schmidt Michael V Holmes David Preiss Daniel I Swerdlow Spiros Denaxas Ghazaleh Fatemifar Rupert Faraway Chris Finan Dennis Valentine Zammy Fairhurst-Hunter Fernando Pires Hartwig Bernardo Lessa Horta Elina Hypponen Christine Power Max Moldovan Erik van Iperen Kees Hovingh Ilja Demuth Kristina Norman Elisabeth Steinhagen-Thiessen Juri Demuth Lars Bertram Christina M Lill Stefan Coassin Johann Willeit Stefan Kiechl Karin Willeit Dan Mason John Wright Richard Morris Goya Wanamethee Peter Whincup Yoav Ben-Shlomo Stela McLachlan Jackie F Price Mika Kivimaki Catherine Welch Adelaida Sanchez-Galvez Pedro Marques-Vidal Andrew Nicolaides Andrie G Panayiotou N Charlotte Onland-Moret Yvonne T van der Schouw Giuseppe Matullo Giovanni Fiorito Simonetta Guarrera Carlotta Sacerdote Nicholas J Wareham Claudia Langenberg Robert A Scott Jian'an Luan Martin Bobak Sofia Malyutina Andrzej Pająk Ruzena Kubinova Abdonas Tamosiunas Hynek Pikhart Niels Grarup Oluf Pedersen Torben Hansen Allan Linneberg Tine Jess Jackie Cooper Steve E Humphries Murray Brilliant Terrie Kitchner Hakon Hakonarson David S Carrell Catherine A McCarty Kirchner H Lester Eric B Larson David R Crosslin Mariza de Andrade Dan M Roden Joshua C Denny Cara Carty Stephen Hancock John Attia Elizabeth Holliday Rodney Scott Peter Schofield Martin O'Donnell Salim Yusuf Michael Chong Guillaume Pare Pim van der Harst M Abdullah Said Ruben N Eppinga Niek Verweij Harold Snieder Tim Christen D O Mook-Kanamori Stefan Gustafsson Lars Lind Erik Ingelsson Raha Pazoki Oscar Franco Albert Hofman Andre Uitterlinden Abbas Dehghan Alexander Teumer Sebastian Baumeister Marcus Dörr Markus M Lerch Uwe Völker Henry Völzke Joey Ward Jill P Pell Tom Meade Ingrid E Christophersen Anke H Maitland-van der Zee Ekaterina V Baranova Robin Young Ian Ford Archie Campbell Sandosh Padmanabhan Michiel L Bots Diederick E Grobbee Philippe Froguel Dorothée Thuillier Ronan Roussel Amélie Bonnefond Bertrand Cariou Melissa Smart Yanchun Bao Meena Kumari Anubha Mahajan Jemma C Hopewell Sudha Seshadri Caroline Dale Rui Providencia E Costa Paul M Ridker Daniel I Chasman Alex P Reiner Marylyn D Ritchie Leslie A Lange Alex J Cornish Sara E Dobbins Kari Hemminki Ben Kinnersley Marc Sanson Karim Labreche Matthias Simon Melissa Bondy Philip Law Helen Speedy James Allan Ni Li Molly Went Niels Weinhold Gareth Morgan Pieter Sonneveld Björn Nilsson Hartmut Goldschmidt Amit Sud Andreas Engert Markus Hansson Harry Hemingway Folkert W Asselbergs Riyaz S Patel Brendan J Keating Naveed Sattar Richard Houlston Juan P Casas Aroon D Hingorani

BMC Cardiovasc Disord 2019 10 29;19(1):240. Epub 2019 Oct 29.

Institute of Cardiovascular Science, University College London, 222 Euston Road, London, NW1 2DA, UK.

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http://dx.doi.org/10.1186/s12872-019-1187-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820948PMC
October 2019

Associations of autozygosity with a broad range of human phenotypes.

Authors:
David W Clark Yukinori Okada Kristjan H S Moore Dan Mason Nicola Pirastu Ilaria Gandin Hannele Mattsson Catriona L K Barnes Kuang Lin Jing Hua Zhao Patrick Deelen Rebecca Rohde Claudia Schurmann Xiuqing Guo Franco Giulianini Weihua Zhang Carolina Medina-Gomez Robert Karlsson Yanchun Bao Traci M Bartz Clemens Baumbach Ginevra Biino Matthew J Bixley Marco Brumat Jin-Fang Chai Tanguy Corre Diana L Cousminer Annelot M Dekker David A Eccles Kristel R van Eijk Christian Fuchsberger He Gao Marine Germain Scott D Gordon Hugoline G de Haan Sarah E Harris Edith Hofer Alicia Huerta-Chagoya Catherine Igartua Iris E Jansen Yucheng Jia Tim Kacprowski Torgny Karlsson Marcus E Kleber Shengchao Alfred Li Ruifang Li-Gao Anubha Mahajan Koichi Matsuda Karina Meidtner Weihua Meng May E Montasser Peter J van der Most Matthias Munz Teresa Nutile Teemu Palviainen Gauri Prasad Rashmi B Prasad Tallapragada Divya Sri Priyanka Federica Rizzi Erika Salvi Bishwa R Sapkota Daniel Shriner Line Skotte Melissa C Smart Albert Vernon Smith Ashley van der Spek Cassandra N Spracklen Rona J Strawbridge Salman M Tajuddin Stella Trompet Constance Turman Niek Verweij Clara Viberti Lihua Wang Helen R Warren Robyn E Wootton Lisa R Yanek Jie Yao Noha A Yousri Wei Zhao Adebowale A Adeyemo Saima Afaq Carlos Alberto Aguilar-Salinas Masato Akiyama Matthew L Albert Matthew A Allison Maris Alver Tin Aung Fereidoun Azizi Amy R Bentley Heiner Boeing Eric Boerwinkle Judith B Borja Gert J de Borst Erwin P Bottinger Linda Broer Harry Campbell Stephen Chanock Miao-Li Chee Guanjie Chen Yii-Der I Chen Zhengming Chen Yen-Feng Chiu Massimiliano Cocca Francis S Collins Maria Pina Concas Janie Corley Giovanni Cugliari Rob M van Dam Anna Damulina Maryam S Daneshpour Felix R Day Graciela E Delgado Klodian Dhana Alexander S F Doney Marcus Dörr Ayo P Doumatey Nduna Dzimiri S Sunna Ebenesersdóttir Joshua Elliott Paul Elliott Ralf Ewert Janine F Felix Krista Fischer Barry I Freedman Giorgia Girotto Anuj Goel Martin Gögele Mark O Goodarzi Mariaelisa Graff Einat Granot-Hershkovitz Francine Grodstein Simonetta Guarrera Daniel F Gudbjartsson Kamran Guity Bjarni Gunnarsson Yu Guo Saskia P Hagenaars Christopher A Haiman Avner Halevy Tamara B Harris Mehdi Hedayati David A van Heel Makoto Hirata Imo Höfer Chao Agnes Hsiung Jinyan Huang Yi-Jen Hung M Arfan Ikram Anuradha Jagadeesan Pekka Jousilahti Yoichiro Kamatani Masahiro Kanai Nicola D Kerrison Thorsten Kessler Kay-Tee Khaw Chiea Chuen Khor Dominique P V de Kleijn Woon-Puay Koh Ivana Kolcic Peter Kraft Bernhard K Krämer Zoltán Kutalik Johanna Kuusisto Claudia Langenberg Lenore J Launer Deborah A Lawlor I-Te Lee Wen-Jane Lee Markus M Lerch Liming Li Jianjun Liu Marie Loh Stephanie J London Stephanie Loomis Yingchang Lu Jian'an Luan Reedik Mägi Ani W Manichaikul Paolo Manunta Gísli Másson Nana Matoba Xue W Mei Christa Meisinger Thomas Meitinger Massimo Mezzavilla Lili Milani Iona Y Millwood Yukihide Momozawa Amy Moore Pierre-Emmanuel Morange Hortensia Moreno-Macías Trevor A Mori Alanna C Morrison Taulant Muka Yoshinori Murakami Alison D Murray Renée de Mutsert Josyf C Mychaleckyj Mike A Nalls Matthias Nauck Matt J Neville Ilja M Nolte Ken K Ong Lorena Orozco Sandosh Padmanabhan Gunnar Pálsson James S Pankow Cristian Pattaro Alison Pattie Ozren Polasek Neil Poulter Peter P Pramstaller Lluis Quintana-Murci Katri Räikkönen Sarju Ralhan Dabeeru C Rao Wouter van Rheenen Stephen S Rich Paul M Ridker Cornelius A Rietveld Antonietta Robino Frank J A van Rooij Daniela Ruggiero Yasaman Saba Charumathi Sabanayagam Maria Sabater-Lleal Cinzia Felicita Sala Veikko Salomaa Kevin Sandow Helena Schmidt Laura J Scott William R Scott Bahareh Sedaghati-Khayat Bengt Sennblad Jessica van Setten Peter J Sever Wayne H-H Sheu Yuan Shi Smeeta Shrestha Sharvari Rahul Shukla Jon K Sigurdsson Timo Tonis Sikka Jai Rup Singh Blair H Smith Alena Stančáková Alice Stanton John M Starr Lilja Stefansdottir Leon Straker Patrick Sulem Gardar Sveinbjornsson Morris A Swertz Adele M Taylor Kent D Taylor Natalie Terzikhan Yih-Chung Tham Gudmar Thorleifsson Unnur Thorsteinsdottir Annika Tillander Russell P Tracy Teresa Tusié-Luna Ioanna Tzoulaki Simona Vaccargiu Jagadish Vangipurapu Jan H Veldink Veronique Vitart Uwe Völker Eero Vuoksimaa Salma M Wakil Melanie Waldenberger Gurpreet S Wander Ya Xing Wang Nicholas J Wareham Sarah Wild Chittaranjan S Yajnik Jian-Min Yuan Lingyao Zeng Liang Zhang Jie Zhou Najaf Amin Folkert W Asselbergs Stephan J L Bakker Diane M Becker Benjamin Lehne David A Bennett Leonard H van den Berg Sonja I Berndt Dwaipayan Bharadwaj Lawrence F Bielak Murielle Bochud Mike Boehnke Claude Bouchard Jonathan P Bradfield Jennifer A Brody Archie Campbell Shai Carmi Mark J Caulfield David Cesarini John C Chambers Giriraj Ratan Chandak Ching-Yu Cheng Marina Ciullo Marilyn Cornelis Daniele Cusi George Davey Smith Ian J Deary Rajkumar Dorajoo Cornelia M van Duijn David Ellinghaus Jeanette Erdmann Johan G Eriksson Evangelos Evangelou Michele K Evans Jessica D Faul Bjarke Feenstra Mary Feitosa Sylvain Foisy Andre Franke Yechiel Friedlander Paolo Gasparini Christian Gieger Clicerio Gonzalez Philippe Goyette Struan F A Grant Lyn R Griffiths Leif Groop Vilmundur Gudnason Ulf Gyllensten Hakon Hakonarson Anders Hamsten Pim van der Harst Chew-Kiat Heng Andrew A Hicks Hagit Hochner Heikki Huikuri Steven C Hunt Vincent W V Jaddoe Philip L De Jager Magnus Johannesson Åsa Johansson Jost B Jonas J Wouter Jukema Juhani Junttila Jaakko Kaprio Sharon L R Kardia Fredrik Karpe Meena Kumari Markku Laakso Sander W van der Laan Jari Lahti Matthias Laudes Rodney A Lea Wolfgang Lieb Thomas Lumley Nicholas G Martin Winfried März Giuseppe Matullo Mark I McCarthy Sarah E Medland Tony R Merriman Andres Metspalu Brian F Meyer Karen L Mohlke Grant W Montgomery Dennis Mook-Kanamori Patricia B Munroe Kari E North Dale R Nyholt Jeffery R O'connell Carole Ober Albertine J Oldehinkel Walter Palmas Colin Palmer Gerard G Pasterkamp Etienne Patin Craig E Pennell Louis Perusse Patricia A Peyser Mario Pirastu Tinca J C Polderman David J Porteous Danielle Posthuma Bruce M Psaty John D Rioux Fernando Rivadeneira Charles Rotimi Jerome I Rotter Igor Rudan Hester M Den Ruijter Dharambir K Sanghera Naveed Sattar Reinhold Schmidt Matthias B Schulze Heribert Schunkert Robert A Scott Alan R Shuldiner Xueling Sim Neil Small Jennifer A Smith Nona Sotoodehnia E-Shyong Tai Alexander Teumer Nicholas J Timpson Daniela Toniolo David-Alexandre Tregouet Tiinamaija Tuomi Peter Vollenweider Carol A Wang David R Weir John B Whitfield Cisca Wijmenga Tien-Yin Wong John Wright Jingyun Yang Lei Yu Babette S Zemel Alan B Zonderman Markus Perola Patrik K E Magnusson André G Uitterlinden Jaspal S Kooner Daniel I Chasman Ruth J F Loos Nora Franceschini Lude Franke Chris S Haley Caroline Hayward Robin G Walters John R B Perry Tōnu Esko Agnar Helgason Kari Stefansson Peter K Joshi Michiaki Kubo James F Wilson

Nat Commun 2019 10 31;10(1):4957. Epub 2019 Oct 31.

Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, EH8 9AG, Scotland.

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http://dx.doi.org/10.1038/s41467-019-12283-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823371PMC
October 2019

Risk for Heart Failure: The Opportunity for Prevention With the American Heart Association's Life's Simple 7.

JACC Heart Fail 2019 08 10;7(8):637-647. Epub 2019 Jul 10.

Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.

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http://dx.doi.org/10.1016/j.jchf.2019.03.009DOI Listing
August 2019

Indoxyl Sulfate Stimulates Angiogenesis by Regulating Reactive Oxygen Species Production via CYP1B1.

Toxins (Basel) 2019 08 2;11(8). Epub 2019 Aug 2.

Department of Nephrology and Hypertension, DIGD, UMC Utrecht, University of Utrecht, 3584 CX Utrecht, The Netherlands.

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http://dx.doi.org/10.3390/toxins11080454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723868PMC
August 2019

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.

Authors:
Valérie Turcot Yingchang Lu Heather M Highland Claudia Schurmann Anne E Justice Rebecca S Fine Jonathan P Bradfield Tõnu Esko Ayush Giri Mariaelisa Graff Xiuqing Guo Audrey E Hendricks Tugce Karaderi Adelheid Lempradl Adam E Locke Anubha Mahajan Eirini Marouli Suthesh Sivapalaratnam Kristin L Young Tamuno Alfred Mary F Feitosa Nicholas G D Masca Alisa K Manning Carolina Medina-Gomez Poorva Mudgal Maggie C Y Ng Alex P Reiner Sailaja Vedantam Sara M Willems Thomas W Winkler Gonçalo Abecasis Katja K Aben Dewan S Alam Sameer E Alharthi Matthew Allison Philippe Amouyel Folkert W Asselbergs Paul L Auer Beverley Balkau Lia E Bang Inês Barroso Lisa Bastarache Marianne Benn Sven Bergmann Lawrence F Bielak Matthias Blüher Michael Boehnke Heiner Boeing Eric Boerwinkle Carsten A Böger Jette Bork-Jensen Michiel L Bots Erwin P Bottinger Donald W Bowden Ivan Brandslund Gerome Breen Murray H Brilliant Linda Broer Marco Brumat Amber A Burt Adam S Butterworth Peter T Campbell Stefania Cappellani David J Carey Eulalia Catamo Mark J Caulfield John C Chambers Daniel I Chasman Yii-Der I Chen Rajiv Chowdhury Cramer Christensen Audrey Y Chu Massimiliano Cocca Francis S Collins James P Cook Janie Corley Jordi Corominas Galbany Amanda J Cox David S Crosslin Gabriel Cuellar-Partida Angela D'Eustacchio John Danesh Gail Davies Paul I W Bakker Mark C H Groot Renée Mutsert Ian J Deary George Dedoussis Ellen W Demerath Martin Heijer Anneke I Hollander Hester M Ruijter Joe G Dennis Josh C Denny Emanuele Di Angelantonio Fotios Drenos Mengmeng Du Marie-Pierre Dubé Alison M Dunning Douglas F Easton Todd L Edwards David Ellinghaus Patrick T Ellinor Paul Elliott Evangelos Evangelou Aliki-Eleni Farmaki I Sadaf Farooqi Jessica D Faul Sascha Fauser Shuang Feng Ele Ferrannini Jean Ferrieres Jose C Florez Ian Ford Myriam Fornage Oscar H Franco Andre Franke Paul W Franks Nele Friedrich Ruth Frikke-Schmidt Tessel E Galesloot Wei Gan Ilaria Gandin Paolo Gasparini Jane Gibson Vilmantas Giedraitis Anette P Gjesing Penny Gordon-Larsen Mathias Gorski Hans-Jörgen Grabe Struan F A Grant Niels Grarup Helen L Griffiths Megan L Grove Vilmundur Gudnason Stefan Gustafsson Jeff Haessler Hakon Hakonarson Anke R Hammerschlag Torben Hansen Kathleen Mullan Harris Tamara B Harris Andrew T Hattersley Christian T Have Caroline Hayward Liang He Nancy L Heard-Costa Andrew C Heath Iris M Heid Øyvind Helgeland Jussi Hernesniemi Alex W Hewitt Oddgeir L Holmen G Kees Hovingh Joanna M M Howson Yao Hu Paul L Huang Jennifer E Huffman M Arfan Ikram Erik Ingelsson Anne U Jackson Jan-Håkan Jansson Gail P Jarvik Gorm B Jensen Yucheng Jia Stefan Johansson Marit E Jørgensen Torben Jørgensen J Wouter Jukema Bratati Kahali René S Kahn Mika Kähönen Pia R Kamstrup Stavroula Kanoni Jaakko Kaprio Maria Karaleftheri Sharon L R Kardia Fredrik Karpe Sekar Kathiresan Frank Kee Lambertus A Kiemeney Eric Kim Hidetoshi Kitajima Pirjo Komulainen Jaspal S Kooner Charles Kooperberg Tellervo Korhonen Peter Kovacs Helena Kuivaniemi Zoltán Kutalik Kari Kuulasmaa Johanna Kuusisto Markku Laakso Timo A Lakka David Lamparter Ethan M Lange Leslie A Lange Claudia Langenberg Eric B Larson Nanette R Lee Terho Lehtimäki Cora E Lewis Huaixing Li Jin Li Ruifang Li-Gao Honghuang Lin Keng-Hung Lin Li-An Lin Xu Lin Lars Lind Jaana Lindström Allan Linneberg Ching-Ti Liu Dajiang J Liu Yongmei Liu Ken S Lo Artitaya Lophatananon Andrew J Lotery Anu Loukola Jian'an Luan Steven A Lubitz Leo-Pekka Lyytikäinen Satu Männistö Gaëlle Marenne Angela L Mazul Mark I McCarthy Roberta McKean-Cowdin Sarah E Medland Karina Meidtner Lili Milani Vanisha Mistry Paul Mitchell Karen L Mohlke Leena Moilanen Marie Moitry Grant W Montgomery Dennis O Mook-Kanamori Carmel Moore Trevor A Mori Andrew D Morris Andrew P Morris Martina Müller-Nurasyid Patricia B Munroe Mike A Nalls Narisu Narisu Christopher P Nelson Matt Neville Sune F Nielsen Kjell Nikus Pål R Njølstad Børge G Nordestgaard Dale R Nyholt Jeffrey R O'Connel Michelle L O'Donoghue Loes M Olde Loohuis Roel A Ophoff Katharine R Owen Chris J Packard Sandosh Padmanabhan Colin N A Palmer Nicholette D Palmer Gerard Pasterkamp Aniruddh P Patel Alison Pattie Oluf Pedersen Peggy L Peissig Gina M Peloso Craig E Pennell Markus Perola James A Perry John R B Perry Tune H Pers Thomas N Person Annette Peters Eva R B Petersen Patricia A Peyser Ailith Pirie Ozren Polasek Tinca J Polderman Hannu Puolijoki Olli T Raitakari Asif Rasheed Rainer Rauramaa Dermot F Reilly Frida Renström Myriam Rheinberger Paul M Ridker John D Rioux Manuel A Rivas David J Roberts Neil R Robertson Antonietta Robino Olov Rolandsson Igor Rudan Katherine S Ruth Danish Saleheen Veikko Salomaa Nilesh J Samani Yadav Sapkota Naveed Sattar Robert E Schoen Pamela J Schreiner Matthias B Schulze Robert A Scott Marcelo P Segura-Lepe Svati H Shah Wayne H-H Sheu Xueling Sim Andrew J Slater Kerrin S Small Albert V Smith Lorraine Southam Timothy D Spector Elizabeth K Speliotes John M Starr Kari Stefansson Valgerdur Steinthorsdottir Kathleen E Stirrups Konstantin Strauch Heather M Stringham Michael Stumvoll Liang Sun Praveen Surendran Amy J Swift Hayato Tada Katherine E Tansey Jean-Claude Tardif Kent D Taylor Alexander Teumer Deborah J Thompson Gudmar Thorleifsson Unnur Thorsteinsdottir Betina H Thuesen Anke Tönjes Gerard Tromp Stella Trompet Emmanouil Tsafantakis Jaakko Tuomilehto Anne Tybjaerg-Hansen Jonathan P Tyrer Rudolf Uher André G Uitterlinden Matti Uusitupa Sander W Laan Cornelia M Duijn Nienke Leeuwen Jessica van Setten Mauno Vanhala Anette Varbo Tibor V Varga Rohit Varma Digna R Velez Edwards Sita H Vermeulen Giovanni Veronesi Henrik Vestergaard Veronique Vitart Thomas F Vogt Uwe Völker Dragana Vuckovic Lynne E Wagenknecht Mark Walker Lars Wallentin Feijie Wang Carol A Wang Shuai Wang Yiqin Wang Erin B Ware Nicholas J Wareham Helen R Warren Dawn M Waterworth Jennifer Wessel Harvey D White Cristen J Willer James G Wilson Daniel R Witte Andrew R Wood Ying Wu Hanieh Yaghootkar Jie Yao Pang Yao Laura M Yerges-Armstrong Robin Young Eleftheria Zeggini Xiaowei Zhan Weihua Zhang Jing Hua Zhao Wei Zhao Wei Zhao Wei Zhou Krina T Zondervan Jerome I Rotter John A Pospisilik Fernando Rivadeneira Ingrid B Borecki Panos Deloukas Timothy M Frayling Guillaume Lettre Kari E North Cecilia M Lindgren Joel N Hirschhorn Ruth J F Loos

Nat Genet 2019 Jul;51(7):1191-1192

Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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July 2019

Use of Pharmacogenetic Drugs by the Dutch Population.

Front Genet 2019 2;10:567. Epub 2019 Jul 2.

Division Heart and Lungs, Department of Cardiology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.

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http://dx.doi.org/10.3389/fgene.2019.00567DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614185PMC
July 2019

The Translational Landscape of the Human Heart.

Cell 2019 06 30;178(1):242-260.e29. Epub 2019 May 30.

Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin, Germany; DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, 13347 Berlin, Germany; Berlin Institute of Health (BIH), 10178 Berlin, Germany; Charité-Universitätsmedizin, 10117 Berlin, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.05.010DOI Listing
June 2019

The effect of computerized decision support systems on cardiovascular risk factors: a systematic review and meta-analysis.

BMC Med Inform Decis Mak 2019 06 10;19(1):108. Epub 2019 Jun 10.

Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, University of Utrecht, Heidelberglaan 100, 3584, CX, Utrecht, the Netherlands.

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http://dx.doi.org/10.1186/s12911-019-0824-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558725PMC
June 2019

Big data analytics in adult congenital heart disease: why coding matters.

Eur Heart J 2019 04;40(13):1078-1080

Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, Utrecht, The Netherlands.

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http://dx.doi.org/10.1093/eurheartj/ehz089DOI Listing
April 2019

Subsequent Event Risk in Individuals With Established Coronary Heart Disease.

Authors:
Riyaz S Patel Vinicius Tragante Amand F Schmidt Raymond O McCubrey Michael V Holmes Laurence J Howe Kenan Direk Axel Åkerblom Karin Leander Salim S Virani Karol A Kaminski Jochen D Muehlschlegel Hooman Allayee Peter Almgren Maris Alver Ekaterina V Baranova Hassan Behloui Bram Boeckx Peter S Braund Lutz P Breitling Graciela Delgado Nubia E Duarte Marie-Pierre Dubé Line Dufresne Niclas Eriksson Luisa Foco Markus Scholz Crystel M Gijsberts Charlotte Glinge Yan Gong Jaana Hartiala Mahyar Heydarpour Jaroslav A Hubacek Marcus Kleber Daniel Kofink Salma Kotti Pekka Kuukasjärvi Vei-Vei Lee Andreas Leiherer Petra A Lenzini Daniel Levin Leo-Pekka Lyytikäinen Nicola Martinelli Ute Mons Christopher P Nelson Kjell Nikus Anna P Pilbrow Rafal Ploski Yan V Sun Michael W T Tanck W H Wilson Tang Stella Trompet Sander W van der Laan Jessica Van Setten Ragnar O Vilmundarson Chiara Viviani Anselmi Efthymia Vlachopoulou Lawien Al Ali Eric Boerwinkle Carlo Briguori John F Carlquist Kathryn F Carruthers Gavino Casu John Deanfield Panos Deloukas Frank Dudbridge Thomas Engstrøm Natalie Fitzpatrick Kim Fox Bruna Gigante Stefan James Marja-Liisa Lokki Paulo A Lotufo Nicola Marziliano Ify R Mordi Joseph B Muhlestein Christopher Newton-Cheh Jan Pitha Christoph H Saely Ayman Samman-Tahhan Pratik B Sandesara Andrej Teren Adam Timmis Frans Van de Werf Els Wauters Arthur A M Wilde Ian Ford David J Stott Ale Algra Maria G Andreassi Diego Ardissino Benoit J Arsenault Christie M Ballantyne Thomas O Bergmeijer Connie R Bezzina Simon C Body Eric H Boersma Peter Bogaty Michiel L Bots Hermann Brenner Jasper J Brugts Ralph Burkhardt Clara Carpeggiani Gianluigi Condorelli Rhonda M Cooper-DeHoff Sharon Cresci Nicolas Danchin Ulf de Faire Robert N Doughty Heinz Drexel James C Engert Keith A A Fox Domenico Girelli Diederick E Grobbee Emil Hagström Stanley L Hazen Claes Held Harry Hemingway Imo E Hoefer G Kees Hovingh Reza Jabbari Julie A Johnson J Wouter Jukema Marcin P Kaczor Mika Kähönen Jiri Kettner Marek Kiliszek Olaf H Klungel Bo Lagerqvist Diether Lambrechts Jari O Laurikka Terho Lehtimäki Daniel Lindholm B K Mahmoodi Anke H Maitland-van der Zee Ruth McPherson Olle Melander Andres Metspalu Anna Niemcunowicz-Janica Oliviero Olivieri Grzegorz Opolski Colin N Palmer Gerard Pasterkamp Carl J Pepine Alexandre C Pereira Louise Pilote Arshed A Quyyumi A Mark Richards Marek Sanak Agneta Siegbahn Tabassome Simon Juha Sinisalo J Gustav Smith John A Spertus Steen Stender Alexandre F R Stewart Wojciech Szczeklik Anna Szpakowicz Jean-Claude Tardif Jurriën M Ten Berg Jacob Tfelt-Hansen George Thanassoulis Joachim Thiery Christian Torp-Pedersen Yolanda van der Graaf Frank L J Visseren Johannes Waltenberger Peter E Weeke Pim Van der Harst Chim C Lang Naveed Sattar Vicky A Cameron Jeffrey L Anderson James M Brophy Guillaume Pare Benjamin D Horne Winfried März Lars Wallentin Nilesh J Samani Aroon D Hingorani Folkert W Asselbergs

Circ Genom Precis Med 2019 04 21;12(4):e002470. Epub 2019 Mar 21.

Institute of Health Informatics (N.F., A. Timmis, H.H., F.W.A.), Faculty of Population Health Science, University College London, United Kingdom.

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http://dx.doi.org/10.1161/CIRCGEN.119.002470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6629546PMC
April 2019

Association of Chromosome 9p21 With Subsequent Coronary Heart Disease Events.

Authors:
Riyaz S Patel Amand F Schmidt Vinicius Tragante Raymond O McCubrey Michael V Holmes Laurence J Howe Kenan Direk Axel Åkerblom Karin Leander Salim S Virani Karol A Kaminski Jochen D Muehlschlegel Marie-Pierre Dubé Hooman Allayee Peter Almgren Maris Alver Ekaterina V Baranova Hassan Behlouli Bram Boeckx Peter S Braund Lutz P Breitling Graciela Delgado Nubia E Duarte Line Dufresne Niclas Eriksson Luisa Foco Crystel M Gijsberts Yan Gong Jaana Hartiala Mahyar Heydarpour Jaroslav A Hubacek Marcus Kleber Daniel Kofink Pekka Kuukasjärvi Vei-Vei Lee Andreas Leiherer Petra A Lenzini Daniel Levin Leo-Pekka Lyytikäinen Nicola Martinelli Ute Mons Christopher P Nelson Kjell Nikus Anna P Pilbrow Rafal Ploski Yan V Sun Michael W T Tanck W H Wilson Tang Stella Trompet Sander W van der Laan Jessica van Setten Ragnar O Vilmundarson Chiara Viviani Anselmi Efthymia Vlachopoulou Eric Boerwinkle Carlo Briguori John F Carlquist Kathryn F Carruthers Gavino Casu John Deanfield Panos Deloukas Frank Dudbridge Natalie Fitzpatrick Bruna Gigante Stefan James Marja-Liisa Lokki Paulo A Lotufo Nicola Marziliano Ify R Mordi Joseph B Muhlestein Chris Newton Cheh Jan Pitha Christoph H Saely Ayman Samman-Tahhan Pratik B Sandesara Andrej Teren Adam Timmis Frans Van de Werf Els Wauters Arthur A M Wilde Ian Ford David J Stott Ale Algra Maria G Andreassi Diego Ardissino Benoit J Arsenault Christie M Ballantyne Thomas O Bergmeijer Connie R Bezzina Simon C Body Peter Bogaty Gert J de Borst Hermann Brenner Ralph Burkhardt Clara Carpeggiani Gianluigi Condorelli Rhonda M Cooper-DeHoff Sharon Cresci Ulf de Faire Robert N Doughty Heinz Drexel James C Engert Keith A A Fox Domenico Girelli Emil Hagström Stanley L Hazen Claes Held Harry Hemingway Imo E Hoefer G Kees Hovingh Julie A Johnson Pim A de Jong J Wouter Jukema Marcin P Kaczor Mika Kähönen Jiri Kettner Marek Kiliszek Olaf H Klungel Bo Lagerqvist Diether Lambrechts Jari O Laurikka Terho Lehtimäki Daniel Lindholm Bakhtawar K Mahmoodi Anke H Maitland-van der Zee Ruth McPherson Olle Melander Andres Metspalu Witold Pepinski Oliviero Olivieri Grzegorz Opolski Colin N Palmer Gerard Pasterkamp Carl J Pepine Alexandre C Pereira Louise Pilote Arshed A Quyyumi A Mark Richards Marek Sanak Markus Scholz Agneta Siegbahn Juha Sinisalo J Gustav Smith John A Spertus Alexandre F R Stewart Wojciech Szczeklik Anna Szpakowicz Jurriën M Ten Berg George Thanassoulis Joachim Thiery Yolanda van der Graaf Frank L J Visseren Johannes Waltenberger Pim Van der Harst Jean-Claude Tardif Naveed Sattar Chim C Lang Guillaume Pare James M Brophy Jeffrey L Anderson Winfried März Lars Wallentin Vicky A Cameron Benjamin D Horne Nilesh J Samani Aroon D Hingorani Folkert W Asselbergs

Circ Genom Precis Med 2019 04 21;12(4):e002471. Epub 2019 Mar 21.

Institute of Cardiovascular Science, Faculty of Population Health Science (R.S.P., A.F.S., L.J.H., K.D., J.D., A.D.H., F.W.A.).

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6625876PMC
April 2019

Adverse Drug Reactions to Guideline-Recommended Heart Failure Drugs in Women: A Systematic Review of the Literature.

JACC Heart Fail 2019 03;7(3):258-266

Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.jchf.2019.01.009DOI Listing
March 2019

The prevalence of pseudoxanthoma elasticum: Revised estimations based on genotyping in a high vascular risk cohort.

Eur J Med Genet 2019 Feb 22;62(2):90-92. Epub 2018 May 22.

Department of Vascular Medicine, University Medical Center Utrecht, Utrecht University, the Netherlands. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S17697212173088
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http://dx.doi.org/10.1016/j.ejmg.2018.05.020DOI Listing
February 2019

[Hypertrophic cardiomyopathy].

Ned Tijdschr Geneeskd 2019 02 7;163. Epub 2019 Feb 7.

Erasmus MC, afd. Cardiologie, Rotterdam.

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February 2019

Non-HLA Genetic Factors and Their Influence on Heart Transplant Outcomes: A Systematic Review.

Transplant Direct 2019 Feb 21;5(2):e422. Epub 2019 Jan 21.

Division Heart and Lungs, Department of Cardiology, University Medical Center Utrecht, University of Utrecht, Utrecht, the Netherlands.

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http://dx.doi.org/10.1097/TXD.0000000000000859DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415970PMC
February 2019

Can advanced analytics fix modern medicine's problem of uncertainty, imprecision, and inaccuracy?

Eur J Heart Fail 2019 01 10;21(1):86-89. Epub 2018 Dec 10.

Health Data Research UK and Institute of Health Informatics, University College London, London, UK.

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http://dx.doi.org/10.1002/ejhf.1370DOI Listing
January 2019

Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci.

Authors:
A Mesut Erzurumluoglu Mengzhen Liu Victoria E Jackson Daniel R Barnes Gargi Datta Carl A Melbourne Robin Young Chiara Batini Praveen Surendran Tao Jiang Sheikh Daud Adnan Saima Afaq Arpana Agrawal Elisabeth Altmaier Antonis C Antoniou Folkert W Asselbergs Clemens Baumbach Laura Bierut Sarah Bertelsen Michael Boehnke Michiel L Bots David M Brazel John C Chambers Jenny Chang-Claude Chu Chen Janie Corley Yi-Ling Chou Sean P David Rudolf A de Boer Christiaan A de Leeuw Joe G Dennis Anna F Dominiczak Alison M Dunning Douglas F Easton Charles Eaton Paul Elliott Evangelos Evangelou Jessica D Faul Tatiana Foroud Alison Goate Jian Gong Hans J Grabe Jeff Haessler Christopher Haiman Göran Hallmans Anke R Hammerschlag Sarah E Harris Andrew Hattersley Andrew Heath Chris Hsu William G Iacono Stavroula Kanoni Manav Kapoor Jaakko Kaprio Sharon L Kardia Fredrik Karpe Jukka Kontto Jaspal S Kooner Charles Kooperberg Kari Kuulasmaa Markku Laakso Dongbing Lai Claudia Langenberg Nhung Le Guillaume Lettre Anu Loukola Jian'an Luan Pamela A F Madden Massimo Mangino Riccardo E Marioni Eirini Marouli Jonathan Marten Nicholas G Martin Matt McGue Kyriaki Michailidou Evelin Mihailov Alireza Moayyeri Marie Moitry Martina Müller-Nurasyid Aliya Naheed Matthias Nauck Matthew J Neville Sune Fallgaard Nielsen Kari North Markus Perola Paul D P Pharoah Giorgio Pistis Tinca J Polderman Danielle Posthuma Neil Poulter Beenish Qaiser Asif Rasheed Alex Reiner Frida Renström John Rice Rebecca Rohde Olov Rolandsson Nilesh J Samani Maria Samuel David Schlessinger Steven H Scholte Robert A Scott Peter Sever Yaming Shao Nick Shrine Jennifer A Smith John M Starr Kathleen Stirrups Danielle Stram Heather M Stringham Ioanna Tachmazidou Jean-Claude Tardif Deborah J Thompson Hilary A Tindle Vinicius Tragante Stella Trompet Valerie Turcot Jessica Tyrrell Ilonca Vaartjes Andries R van der Leij Peter van der Meer Tibor V Varga Niek Verweij Henry Völzke Nicholas J Wareham Helen R Warren David R Weir Stefan Weiss Leah Wetherill Hanieh Yaghootkar Ersin Yavas Yu Jiang Fang Chen Xiaowei Zhan Weihua Zhang Wei Zhao Wei Zhao Kaixin Zhou Philippe Amouyel Stefan Blankenberg Mark J Caulfield Rajiv Chowdhury Francesco Cucca Ian J Deary Panos Deloukas Emanuele Di Angelantonio Marco Ferrario Jean Ferrières Paul W Franks Tim M Frayling Philippe Frossard Ian P Hall Caroline Hayward Jan-Håkan Jansson J Wouter Jukema Frank Kee Satu Männistö Andres Metspalu Patricia B Munroe Børge Grønne Nordestgaard Colin N A Palmer Veikko Salomaa Naveed Sattar Timothy Spector David Peter Strachan Pim van der Harst Eleftheria Zeggini Danish Saleheen Adam S Butterworth Louise V Wain Goncalo R Abecasis John Danesh Martin D Tobin Scott Vrieze Dajiang J Liu Joanna M M Howson

Mol Psychiatry 2019 Jan 7. Epub 2019 Jan 7.

MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK.

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http://www.nature.com/articles/s41380-018-0313-0
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http://dx.doi.org/10.1038/s41380-018-0313-0DOI Listing
January 2019

Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting.

Authors:
Ganesh Chauhan Hieab H H Adams Claudia L Satizabal Joshua C Bis Alexander Teumer Muralidharan Sargurupremraj Edith Hofer Stella Trompet Saima Hilal Albert Vernon Smith Xueqiu Jian Rainer Malik Matthew Traylor Sara L Pulit Philippe Amouyel Bernard Mazoyer Yi-Cheng Zhu Sara Kaffashian Sabrina Schilling Gary W Beecham Thomas J Montine Gerard D Schellenberg Olafur Kjartansson Vilmundur Guðnason David S Knopman Michael E Griswold B Gwen Windham Rebecca F Gottesman Thomas H Mosley Reinhold Schmidt Yasaman Saba Helena Schmidt Fumihiko Takeuchi Shuhei Yamaguchi Toru Nabika Norihiro Kato Kumar B Rajan Neelum T Aggarwal Philip L De Jager Denis A Evans Bruce M Psaty Jerome I Rotter Kenneth Rice Oscar L Lopez Jiemin Liao Christopher Chen Ching-Yu Cheng Tien Y Wong Mohammad K Ikram Sven J van der Lee Najaf Amin Vincent Chouraki Anita L DeStefano Hugo J Aparicio Jose R Romero Pauline Maillard Charles DeCarli Joanna M Wardlaw Maria Del C Valdés Hernández Michelle Luciano David Liewald Ian J Deary John M Starr Mark E Bastin Susana Muñoz Maniega P Eline Slagboom Marian Beekman Joris Deelen Hae-Won Uh Robin Lemmens Henry Brodaty Margaret J Wright David Ames Giorgio B Boncoraglio Jemma C Hopewell Ashley H Beecham Susan H Blanton Clinton B Wright Ralph L Sacco Wei Wen Anbupalam Thalamuthu Nicola J Armstrong Elizabeth Chong Peter R Schofield John B Kwok Jeroen van der Grond David J Stott Ian Ford J Wouter Jukema Meike W Vernooij Albert Hofman André G Uitterlinden Aad van der Lugt Katharina Wittfeld Hans J Grabe Norbert Hosten Bettina von Sarnowski Uwe Völker Christopher Levi Jordi Jimenez-Conde Pankaj Sharma Cathie L M Sudlow Jonathan Rosand Daniel Woo John W Cole James F Meschia Agnieszka Slowik Vincent Thijs Arne Lindgren Olle Melander Raji P Grewal Tatjana Rundek Kathy Rexrode Peter M Rothwell Donna K Arnett Christina Jern Julie A Johnson Oscar R Benavente Sylvia Wasssertheil-Smoller Jin-Moo Lee Quenna Wong Braxton D Mitchell Stephen S Rich Patrick F McArdle Mirjam I Geerlings Yolanda van der Graaf Paul I W de Bakker Folkert W Asselbergs Velandai Srikanth Russell Thomson Rebekah McWhirter Chris Moran Michele Callisaya Thanh Phan Loes C A Rutten-Jacobs Steve Bevan Christophe Tzourio Karen A Mather Perminder S Sachdev Cornelia M van Duijn Bradford B Worrall Martin Dichgans Steven J Kittner Hugh S Markus Mohammad A Ikram Myriam Fornage Lenore J Launer Sudha Seshadri W T Longstreth Stéphanie Debette

Neurology 2019 Jan 16. Epub 2019 Jan 16.

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http://dx.doi.org/10.1212/WNL.0000000000006851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369905PMC
January 2019

Plasminogen activator inhibitor-1 and tissue plasminogen activator and incident AF: Data from the PREVEND study.

Int J Cardiol 2018 Dec 10;272:208-210. Epub 2018 Aug 10.

University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

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http://dx.doi.org/10.1016/j.ijcard.2018.08.029DOI Listing
December 2018

Modelling inherited cardiac disease using human induced pluripotent stem cell-derived cardiomyocytes: progress, pitfalls, and potential.

Cardiovasc Res 2018 12;114(14):1828-1842

Division Heart and Lungs, Department of Cardiology, Experimental Cardiology Laboratory, Regenerative Medicine Center, University Medical Center Utrecht, Internal Mail No G03.550, GA Utrecht, the Netherlands.

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https://academic.oup.com/cardiovascres/advance-article/doi/1
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http://dx.doi.org/10.1093/cvr/cvy208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6887927PMC
December 2018

A comprehensive evaluation of the genetic architecture of sudden cardiac arrest.

Eur Heart J 2018 11;39(44):3961-3969

Cardiovascular Health Research Unit, Division of Cardiology, Departments of Medicine and Epidemiology, University of Washington, 1730 Minor Ave, Seattle, WA, USA.

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http://fdslive.oup.com/www.oup.com/pdf/production_in_progres
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http://dx.doi.org/10.1093/eurheartj/ehy474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247663PMC
November 2018

Mendelian randomization: A powerful method to determine causality of biomarkers in diseases.

Int J Cardiol 2018 10 17;268:227-228. Epub 2018 May 17.

Department of Cardiology, Division Heart & Lungs, University Medical Center Utrecht, Utrecht University, The Netherlands; Durrer Center for Cardiovascular Research, Netherlands Heart Institute, Utrecht, The Netherlands; Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, London, United Kingdom; Farr Institute of Health Informatics Research and Institute of Health Informatics, University College London, London, United Kingdom.

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http://dx.doi.org/10.1016/j.ijcard.2018.05.049DOI Listing
October 2018

Prescription patterns of angiotensin-converting enzyme inhibitors for various indications: A UK population-based study.

Br J Clin Pharmacol 2018 10 24;84(10):2365-2372. Epub 2018 Jul 24.

Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht, The Netherlands.

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http://dx.doi.org/10.1111/bcp.13692DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138483PMC
October 2018

Algorithms used in telemonitoring programmes for patients with chronic heart failure: A systematic review.

Eur J Cardiovasc Nurs 2018 10 29;17(7):580-588. Epub 2018 Jun 29.

1 Department of Cardiology, University Medical Center Utrecht, The Netherlands.

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http://dx.doi.org/10.1177/1474515118786838DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168739PMC
October 2018

From lipid locus to drug target through human genomics.

Cardiovasc Res 2018 07;114(9):1258-1270

Department of Cardiology, University Medical Center Utrecht, University of Utrecht, Heidelberglaan 100, 3584 CX Utrecht, the Netherlands.

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http://dx.doi.org/10.1093/cvr/cvy120DOI Listing
July 2018

Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6.

Authors:
Bram P Prins Timothy J Mead Jennifer A Brody Gardar Sveinbjornsson Ioanna Ntalla Nathan A Bihlmeyer Marten van den Berg Jette Bork-Jensen Stefania Cappellani Stefan Van Duijvenboden Nikolai T Klena George C Gabriel Xiaoqin Liu Cagri Gulec Niels Grarup Jeffrey Haessler Leanne M Hall Annamaria Iorio Aaron Isaacs Ruifang Li-Gao Honghuang Lin Ching-Ti Liu Leo-Pekka Lyytikäinen Jonathan Marten Hao Mei Martina Müller-Nurasyid Michele Orini Sandosh Padmanabhan Farid Radmanesh Julia Ramirez Antonietta Robino Molly Schwartz Jessica van Setten Albert V Smith Niek Verweij Helen R Warren Stefan Weiss Alvaro Alonso David O Arnar Michiel L Bots Rudolf A de Boer Anna F Dominiczak Mark Eijgelsheim Patrick T Ellinor Xiuqing Guo Stephan B Felix Tamara B Harris Caroline Hayward Susan R Heckbert Paul L Huang J W Jukema Mika Kähönen Jan A Kors Pier D Lambiase Lenore J Launer Man Li Allan Linneberg Christopher P Nelson Oluf Pedersen Marco Perez Annette Peters Ozren Polasek Bruce M Psaty Olli T Raitakari Kenneth M Rice Jerome I Rotter Moritz F Sinner Elsayed Z Soliman Tim D Spector Konstantin Strauch Unnur Thorsteinsdottir Andrew Tinker Stella Trompet André Uitterlinden Ilonca Vaartjes Peter van der Meer Uwe Völker Henry Völzke Melanie Waldenberger James G Wilson Zhijun Xie Folkert W Asselbergs Marcus Dörr Cornelia M van Duijn Paolo Gasparini Daniel F Gudbjartsson Vilmundur Gudnason Torben Hansen Stefan Kääb Jørgen K Kanters Charles Kooperberg Terho Lehtimäki Henry J Lin Steven A Lubitz Dennis O Mook-Kanamori Francesco J Conti Christopher H Newton-Cheh Jonathan Rosand Igor Rudan Nilesh J Samani Gianfranco Sinagra Blair H Smith Hilma Holm Bruno H Stricker Sheila Ulivi Nona Sotoodehnia Suneel S Apte Pim van der Harst Kari Stefansson Patricia B Munroe Dan E Arking Cecilia W Lo Yalda Jamshidi

Genome Biol 2018 07 17;19(1):87. Epub 2018 Jul 17.

Genetics Research Centre, Molecular and Clinical Sciences Institute, St George's University of London, London, SW17 0RE, UK.

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http://dx.doi.org/10.1186/s13059-018-1457-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048820PMC
July 2018

PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity.

Authors:
Jessica van Setten Jennifer A Brody Yalda Jamshidi Brenton R Swenson Anne M Butler Harry Campbell Fabiola M Del Greco Daniel S Evans Quince Gibson Daniel F Gudbjartsson Kathleen F Kerr Bouwe P Krijthe Leo-Pekka Lyytikäinen Christian Müller Martina Müller-Nurasyid Ilja M Nolte Sandosh Padmanabhan Marylyn D Ritchie Antonietta Robino Albert V Smith Maristella Steri Toshiko Tanaka Alexander Teumer Stella Trompet Sheila Ulivi Niek Verweij Xiaoyan Yin David O Arnar Folkert W Asselbergs Joel S Bader John Barnard Josh Bis Stefan Blankenberg Eric Boerwinkle Yuki Bradford Brendan M Buckley Mina K Chung Dana Crawford Marcel den Hoed Josh C Denny Anna F Dominiczak Georg B Ehret Mark Eijgelsheim Patrick T Ellinor Stephan B Felix Oscar H Franco Lude Franke Tamara B Harris Hilma Holm Gandin Ilaria Annamaria Iorio Mika Kähönen Ivana Kolcic Jan A Kors Edward G Lakatta Lenore J Launer Honghuang Lin Henry J Lin Ruth J F Loos Steven A Lubitz Peter W Macfarlane Jared W Magnani Irene Mateo Leach Thomas Meitinger Braxton D Mitchell Thomas Munzel George J Papanicolaou Annette Peters Arne Pfeufer Peter P Pramstaller Olli T Raitakari Jerome I Rotter Igor Rudan Nilesh J Samani David Schlessinger Claudia T Silva Aldana Moritz F Sinner Jonathan D Smith Harold Snieder Elsayed Z Soliman Timothy D Spector David J Stott Konstantin Strauch Kirill V Tarasov Unnur Thorsteinsdottir Andre G Uitterlinden David R Van Wagoner Uwe Völker Henry Völzke Melanie Waldenberger Harm Jan Westra Philipp S Wild Tanja Zeller Alvaro Alonso Christy L Avery Stefania Bandinelli Emelia J Benjamin Francesco Cucca Marcus Dörr Luigi Ferrucci Paolo Gasparini Vilmundur Gudnason Caroline Hayward Susan R Heckbert Andrew A Hicks J Wouter Jukema Stefan Kääb Terho Lehtimäki Yongmei Liu Patricia B Munroe Afshin Parsa Ozren Polasek Bruce M Psaty Dan M Roden Renate B Schnabel Gianfranco Sinagra Kari Stefansson Bruno H Stricker Pim van der Harst Cornelia M van Duijn James F Wilson Sina A Gharib Paul I W de Bakker Aaron Isaacs Dan E Arking Nona Sotoodehnia

Nat Commun 2018 07 25;9(1):2904. Epub 2018 Jul 25.

Departments of Medicine and Epidemiology, Cardiovascular Health Research Unit, Division of Cardiology, University of Washington, Seattle, 98101, WA, USA.

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http://dx.doi.org/10.1038/s41467-018-04766-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060178PMC
July 2018

Feasibility and implementation of CYP2C19 genotyping in patients using antiplatelet therapy.

Pharmacogenomics 2018 05 27;19(7):621-628. Epub 2018 Apr 27.

Department of Clinical Pharmacy, University Medical Center Utrecht, 3584 CX, Utrecht, The Netherlands.

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http://dx.doi.org/10.2217/pgs-2018-0013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021912PMC
May 2018

Common and Rare Coding Genetic Variation Underlying the Electrocardiographic PR Interval.

Authors:
Honghuang Lin Jessica van Setten Albert V Smith Nathan A Bihlmeyer Helen R Warren Jennifer A Brody Farid Radmanesh Leanne Hall Niels Grarup Martina Müller-Nurasyid Thibaud Boutin Niek Verweij Henry J Lin Ruifang Li-Gao Marten E van den Berg Jonathan Marten Stefan Weiss Bram P Prins Jeffrey Haessler Leo-Pekka Lyytikäinen Hao Mei Tamara B Harris Lenore J Launer Man Li Alvaro Alonso Elsayed Z Soliman John M Connell Paul L Huang Lu-Chen Weng Heather S Jameson William Hucker Alan Hanley Nathan R Tucker Yii-Der Ida Chen Joshua C Bis Kenneth M Rice Colleen M Sitlani Jan A Kors Zhijun Xie Chengping Wen Jared W Magnani Christopher P Nelson Jørgen K Kanters Moritz F Sinner Konstantin Strauch Annette Peters Melanie Waldenberger Thomas Meitinger Jette Bork-Jensen Oluf Pedersen Allan Linneberg Igor Rudan Rudolf A de Boer Peter van der Meer Jie Yao Xiuqing Guo Kent D Taylor Nona Sotoodehnia Jerome I Rotter Dennis O Mook-Kanamori Stella Trompet Fernando Rivadeneira André Uitterlinden Mark Eijgelsheim Sandosh Padmanabhan Blair H Smith Henry Völzke Stephan B Felix Georg Homuth Uwe Völker Massimo Mangino Timothy D Spector Michiel L Bots Marco Perez Mika Kähönen Olli T Raitakari Vilmundur Gudnason Dan E Arking Patricia B Munroe Bruce M Psaty Cornelia M van Duijn Emelia J Benjamin Jonathan Rosand Nilesh J Samani Torben Hansen Stefan Kääb Ozren Polasek Pim van der Harst Susan R Heckbert J Wouter Jukema Bruno H Stricker Caroline Hayward Marcus Dörr Yalda Jamshidi Folkert W Asselbergs Charles Kooperberg Terho Lehtimäki James G Wilson Patrick T Ellinor Steven A Lubitz Aaron Isaacs

Circ Genom Precis Med 2018 05;11(5):e002037

Section of Computational Biomedicine (H.L.) and Section of Cardiovascular Medicine (E.J.B.), Department of Medicine, Boston University School of Medicine, MA. National Heart Lung and Blood Institute's and Boston University's Framingham Heart Study, MA (H.L., E.J.B.). Department of Cardiology, Division Heart & Lungs, University Medical Center Utrecht, University of Utrecht, The Netherlands (J.v.S., F.W.A.). Icelandic Heart Association, Kopavogur (A.V.S., V.G.). Faculty of Medicine, University of Iceland, Reykjavik (A.V.S., V.G.). Predoctoral Training Program in Human Genetics, McKusick-Nathans Institute of Genetic Medicine (N.A.B.) and McKusick-Nathans Institute of Genetic Medicine (D.E.A.), Johns Hopkins University School of Medicine, Baltimore, MD. William Harvey Research Institute (H.R.W., P.B.M.) and NIHR Barts Cardiovascular Research Unit (H.R.W., P.B.M.), Barts and The London School of Medicine and Dentistry, Queen Mary University of London, United Kingdom. Cardiovascular Health Research Unit, Department of Medicine (J.A.B., J.C.B., C.M.S.), Department of Biostatistics (K.M.R.), Cardiovascular Health Research Unit, Division of Cardiology, Departments of Medicine and Epidemiology (N.S.), Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology and Health Services (B.M.P.), and Cardiovascular Health Research Unit, Department of Epidemiology (S.R.H.), University of Washington, Seattle. Center for Human Genetic Research (F. Radmanesh, J.R.) and Cardiovascular Research Center (P.L.H., L.-C.W., H.S.J., W.H., A.H., N.R.T., P.T.E., S.A.L.), Massachusetts General Hospital, Boston. Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA (L.-C.W., P.T.E., S.A.L.). Department of Cardiovascular Sciences, University of Leicester, United Kingdom (L.H., C.P.N., N.J.S.). NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, United Kingdom (L.H., C.P.N., N.J.S.). The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences (N.G., J.B.-J., O. Pedersen, T.H.), Laboratory of Experimental Cardiology (J.K.K.), and Department of Clinical Medicine, Faculty of Health and Medical Sciences (A.L.), University of Copenhagen, Denmark. Department of Medicine I, University Hospital Munich, Ludwig Maximilian's University Munich, Germany (M.M.-N., M.F.S., S.K.). Chair of Genetic Epidemiology, IBE, Faculty of Medicine, LMU Munich, Germany (K.S.). DZHK (German Cardiovascular Research Centre), Partner Site: Munich Heart Alliance, Germany (M.M.-N., M.F.S., A.P., T.M., S.K.). Institute of Genetic Epidemiology (M.M.-N., K.S.), Institute of Epidemiology II (A.P., M.W.), Research Unit of Molecular Epidemiology (M.W.), and Institute of Human Genetics (T.M.), Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine (T.B., J.M., C.H.) and Usher Institute of Population Health Sciences and Informatics (I.R.), University of Edinburgh, United Kingdom. University of Groningen, University Medical Center Groningen, Department of Cardiology, The Netherlands (N.V., R.A.d.B., P.v.d.M., P.v.d.H.). Institute for Translational Genomics and Population Sciences and Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA (H.J.L., Y.-D.I.C., J.Y., X.G., K.D.T., J.I.R.). Department of Clinical Epidemiology (R.L.-G., D.O.M.-K.) and Department of Cardiology (S.T., J.W.J.), Leiden University Medical Center, The Netherlands. Department of Medical Informatics (M.E.v.d.B.), Human Genomics Facility (F. Rivadeneira), Human Genotyping Facility (A.U.), and Department of Epidemiology (M.E., B.H. Stricker), Erasmus MC, University Medical Center Rotterdam, The Netherlands. Interfaculty Institute for Genetics and Functional Genomics, University Medicine and Ernst-Moritz-Arndt-University Greifswald, Germany (S.W., G.H., U.V.). DZHK (German Cardiovascular Research Centre), Partner Site Greifswald, Germany (S.W., H.V., S.B.F., U.V., M.D.). Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA (J.H., C.K.). Department of Clinical Chemistry, Fimlab Laboratories and Faculty of Medicine and Life Sciences (L.-P.L., T.L.) and Department of Clinical Physiology, Tampere University Hospital and Faculty of Medicine and Life Sciences (M.K.), University of Tampere, Finland. Department of Data Science (H.M.) and Physiology and Biophysics (J.G.W.), University of Mississippi Medical Center, Jackson. Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, MD (T.B.H., L.J.L.). Division of Nephrology and Hypertension, Internal Medicine, School of Medicine, University of Utah, Salt Lake City (M.L.). Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA (A.A.). Epidemiological Cardiology Research Center (EPICARE), Wake Forest School of Medicine, Winston Salem, NC (E.Z.S.). Medical Research Institute (J.M.C.) and Division of Population Health Sciences (B.H. Smith), Ninewells Hospital and Medical School, University of Dundee, United Kingdom. Department of Medical Informatics (J.A.K.) and Genetic Epidemiology Unit, Department of Epidemiology (C.M.v.D.), Erasmus MC, Rotterdam, The Netherlands. TCM Clinical Basis Institute, Zhejiang Chinese Medicine University, Hangzhou, China (Z.X., C.W.). Division of Cardiology, Department of Medicine, UPMC Heart and Vascular Institute, University of Pittsburgh, PA (J.W.M.). German Center for Diabetes Research, Neuherberg, Germany (A.P.). Institute of Human Genetics, Technische Universität München, Germany (T.M.). Research Centre for Prevention and Health, Capital Region of Denmark, Copenhagen (A.L.). Department of Clinical Experimental Research, Rigshospitalet, Denmark (A.L.). British Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Scotland (S.P.). Institute for Community Medicine (H.V.) and Department of Internal Medicine B (S.B.F., M.D.), University Medicine Greifswald, Germany. Department of Twin Research and Genetic Epidemiology, King's College London, United Kingdom (M.M., T.D.S.). Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands (M.L.B.). Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, CA (M.P.). Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, and Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Finland (O.T.R.). Kaiser Permanente Washington Health Research Institute, Kaiser Foundation Health Plan of Washington, Seattle (B.M.P., S.R.H.). Faculty of Medicine, University of Split, Croatia (O. Polasek). Cardiogenetics Lab, Genetics and Molecular Cell Sciences Research Centre, Cardiovascular and Cell Sciences Institute, St George's, University of London, Cranmer Terrace, United Kingdom (B.P.P., Y.J.). Durrer Center for Cardiovascular Research, Netherlands Heart Institute, Utrecht, The Netherlands (F.W.A.). Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, London, United Kingdom (F.W.A.). Farr Institute of Health Informatics Research and Institute of Health Informatics, University College London, London, United Kingdom; CARIM School for Cardiovascular Diseases, Maastricht Centre for Systems Biology (MaCSBio) and Department of Biochemistry, Maastricht University, The Netherlands (A.I.).

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http://dx.doi.org/10.1161/CIRCGEN.117.002037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5951629PMC
May 2018

Integrative Bioinformatics Approaches for Identification of Drug Targets in Hypertension.

Front Cardiovasc Med 2018 4;5:25. Epub 2018 Apr 4.

Department of Cardiology, University Medical Center Utrecht, University of Utrecht, Utrecht, Netherlands.

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http://dx.doi.org/10.3389/fcvm.2018.00025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5894467PMC
April 2018

ExomeChip-Wide Analysis of 95 626 Individuals Identifies 10 Novel Loci Associated With QT and JT Intervals.

Authors:
Nathan A Bihlmeyer Jennifer A Brody Albert Vernon Smith Helen R Warren Honghuang Lin Aaron Isaacs Ching-Ti Liu Jonathan Marten Farid Radmanesh Leanne M Hall Niels Grarup Hao Mei Martina Müller-Nurasyid Jennifer E Huffman Niek Verweij Xiuqing Guo Jie Yao Ruifang Li-Gao Marten van den Berg Stefan Weiss Bram P Prins Jessica van Setten Jeffrey Haessler Leo-Pekka Lyytikäinen Man Li Alvaro Alonso Elsayed Z Soliman Joshua C Bis Tom Austin Yii-Der Ida Chen Bruce M Psaty Tamara B Harrris Lenore J Launer Sandosh Padmanabhan Anna Dominiczak Paul L Huang Zhijun Xie Patrick T Ellinor Jan A Kors Archie Campbell Alison D Murray Christopher P Nelson Martin D Tobin Jette Bork-Jensen Torben Hansen Oluf Pedersen Allan Linneberg Moritz F Sinner Annette Peters Melanie Waldenberger Thomas Meitinger Siegfried Perz Ivana Kolcic Igor Rudan Rudolf A de Boer Peter van der Meer Henry J Lin Kent D Taylor Renée de Mutsert Stella Trompet J Wouter Jukema Arie C Maan Bruno H C Stricker Fernando Rivadeneira André Uitterlinden Uwe Völker Georg Homuth Henry Völzke Stephan B Felix Massimo Mangino Timothy D Spector Michiel L Bots Marco Perez Olli T Raitakari Mika Kähönen Nina Mononen Vilmundur Gudnason Patricia B Munroe Steven A Lubitz Cornelia M van Duijn Christopher H Newton-Cheh Caroline Hayward Jonathan Rosand Nilesh J Samani Jørgen K Kanters James G Wilson Stefan Kääb Ozren Polasek Pim van der Harst Susan R Heckbert Jerome I Rotter Dennis O Mook-Kanamori Mark Eijgelsheim Marcus Dörr Yalda Jamshidi Folkert W Asselbergs Charles Kooperberg Terho Lehtimäki Dan E Arking Nona Sotoodehnia

Circ Genom Precis Med 2018 01;11(1):e001758

From the Predoctoral Training Program in Human Genetics (N.A.B.) and McKusick-Nathans Institute of Genetic Medicine (N.A.B., D.E.A.), Johns Hopkins School of Medicine, Baltimore, MD; Cardiovascular Health Research Unit, Department of Medicine (J.A.B., J.C.B., T.A., N.S.), Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Services (B.M.P.), and Cardiovascular Health Research Unit, Department of Epidemiology (S.R.H.), University of Washington, Seattle; Icelandic Heart Association, Kopavogur (A.V.S., V.G.); Faculty of Medicine, University of Iceland, Reykavik (A.V.S., V.G.); Clinical Pharmacology Department, William Harvey Research Institute, Barts and London School of Medicine and Dentistry (H.R.W., P.B.M.) and NIHR Barts Cardiovascular Biomedical Research Unit (H.R.W., P.B.M.), Queen Mary University of London, United Kingdom; Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, MA (H.L., Z.X.); School for Cardiovascular Diseases, Maastricht Center for Systems Biology and Department of Biochemistry, Maastricht University, The Netherlands (A.I.); Genetic Epidemiology Unit, Department of Epidemiology (A.I., C.M.v.D.) and Department of Medical Informatics (J.A.K.), Erasmus University Medical Center, Rotterdam, The Netherlands; Biostatistics Department, Boston University School of Public Health, MA (C.-T.L.); Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine (J.M., C.H.), Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine (A.C.), and Usher Institute for Population Health Sciences and Informatics (I.R.), University of Edinburgh, United Kingdom; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA (F.R., P.T.E., S.A.L., J.R.); Center for Human Genetic Research (F.R., J.R.), Cardiovascular Research Center (P.L.H., P.T.E., S.A.L.), and Center for Human Genetic Research and Cardiovascular Research Center (C.H.N.-C.), Harvard Medical School, Massachusetts General Hospital, Boston; Department of Cardiovascular Sciences (L.M.H., C.P.N., N.J.S.) and Genetic Epidemiology Group, Department of Health Sciences (M.D.T.), University of Leicester, United Kingdom; NIHR Leicester Cardiovascular Biomedical Research Unit (L.M.H., C.P.N.) and NIHR Leicester Respiratory Biomedical Research Unit (M.D.T.), Glenfield Hospital, United Kingdom; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences (N.G., J.B.-J., T.H., O.P.), Department of Clinical Medicine, Faculty of Health and Medical Sciences (A.L.), and Laboratory of Experimental Cardiology (J.K.K.), University of Copenhagen, Denmark; Department of Data Science, School of Population Health (H.M.) and Physiology and Biophysics (J.G.W.), University of Mississippi Medical Center, Jackson; Institute of Genetic Epidemiology (M.M.-N.), Institute of Epidemiology II (A.P., M.W., S.P.), Research Unit of Molecular Epidemiology (M.W.), and Institute of Human Genetics (T.M.), Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg; Department of Medicine I, University Hospital Munich, Ludwig-Maximilians University, Germany (M.M.-N., M.F.S., S.K.); DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance (M.M.-N., M.F.S., A.P., T.M., S.K.); MRC Human Genetics Unit, MRC IGMM, University of Edinburgh, Scotland (J.E.H.); Department of Cardiology (N.V., R.A.d.B., P.v.d.M., P.v.d.H.) and Department of Internal Medicine (M.E.), University Medical Center Groningen, University of Groningen, The Netherlands; Institute for Translational Genomics and Population Sciences and Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance (X.G., J.Y., Y.-D.I.C.); Department of Clinical Epidemiology (R.L.-G., R.d.M.) and University of Split School of Medicine (I.K., O.P.), University of Split, Croatia; Departments of Cardiology (S.T., J.W.J., A.C.M.), Gerontology and Geriatrics (S.T.), and Public Health and Primary Care (D.O.M.-K.), Leiden University Medical Center, The Netherlands; Departments of Medical Informatics (M.v.d.B.), Epidemiology (B.H.C.S.), and Epidemiology (M.E.), Erasmus MC - University Medical Center Rotterdam, The Netherlands; Interfaculty Institute for Genetics and Functional Genomics, University Medicine and Ernst-Moritz-Arndt-University, Greifswald, Germany (S.W., U.V., G.H.); DZHK (German Centre for Cardiovascular Research), partner site Greifswald (S.W., U.V., H.V., S.B.F., M.D.); Cardiogenetics Lab, Genetics and Molecular Cell Sciences Research Centre, Cardiovascular and Cell Sciences Institute, St George's, University of London, United Kingdom (B.P.P., Y.J.); Division Heart and Lungs, Department of Cardiology, (J.v.S., F.W.A.) and Julius Center for Health Sciences and Primary Care (M.L.B.), University Medical Center Utrecht, The Netherlands; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA (J.H., C.K.); Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland (L.-P.L., N.M., T.L.); Department of Clinical Physiology, Tampere University Hospital, University of Tampere School of Medicine, Finland (M.K.); Division of Nephrology and Hypertension, Internal Medicine, School of Medicine, University of Utah, Salt Lake City (M.L.); Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA (A.A.); Epidemiological Cardiology Research Center (EPICARE), Wake Forest School of Medicine, Winston-Salem, NC (E.Z.S.); Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, MD (T.B.H., L.J.L.); Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, United Kingdom (S.P., A.D.); Institute of Medical Sciences, Aberdeen Biomedical Imaging Centre, University of Aberdeen, United Kingdom (A.D.M.); Research Centre for Prevention and Health, Capital Region of Denmark, Copenhagen (A.L.); Department of Clinical Experimental Research, Rigshospitalet, Glostrup, Denmark (A.L.); German Center for Diabetes Research, Neuherberg (A.P.); Institute of Human Genetics, Technische Universität München, Germany (T.M.); Durrer Center for Cardiogenetic Research, Amsterdam, The Netherlands (J.W.J.); Interuniversity Cardiology Institute of Netherlands, Utrecht (J.W.J.); Inspectorate of Health Care, Utrecht, The Netherlands (B.H.C.S.); Human Genomics Facility (F.R.) and Human Genotyping Facility (A.U.), Erasmus MC - University Medical Center Rotterdam, The Netherlands; Institute for Community Medicine (H.V.) and Department of Internal Medicine B (S.B.F., M.D.), University Medicine Greifswald, Germany; Department of Twin Research and Genetic Epidemiology, King's College London, United Kingdom (M.M., T.D.S.); Stanford School of Medicine, CA (M.P.); Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital and Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Finland (O.T.R.); Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge (C.H.N.-C.); NIHR Leicester Biomedical Research Unit in Cardiovascular Disease, United Kingdom (N.J.S.); Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, Utrecht (F.W.A.); and Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, United Kingdom (F.W.A.).

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http://dx.doi.org/10.1161/CIRCGEN.117.001758DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992491PMC
January 2018