Folkert Kuipers

Folkert Kuipers

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Folkert Kuipers

Folkert Kuipers

Publications by authors named "Folkert Kuipers"

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The Origin of Follicular Bile Acids in the Human Ovary.

Am J Pathol 2019 Oct 29;189(10):2036-2045. Epub 2019 Jul 29.

Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands; Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden; Clinical Chemistry, Karolinska University Laboratory, Karolinska University Hospital, Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2019.06.011DOI Listing
October 2019

Potential of Intestine-Selective FXR Modulation for Treatment of Metabolic Disease.

Handb Exp Pharmacol 2019 ;256:207-234

Department of Pediatrics, University Medical Center Groningen, Faculty Campus Fryslân, University of Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1007/164_2019_233DOI Listing
September 2019

Systems genetics approach reveals cross-talk between bile acids and intestinal microbes.

PLoS Genet 2019 Aug 29;15(8):e1008307. Epub 2019 Aug 29.

Department of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.

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http://dx.doi.org/10.1371/journal.pgen.1008307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6715170PMC
August 2019

Blocking Sodium-Taurocholate Cotransporting Polypeptide Stimulates Biliary Cholesterol and Phospholipid Secretion in Mice.

Hepatology 2019 May 28. Epub 2019 May 28.

Tytgat Institute for Liver and Intestinal Research, Amsterdam Gastroenterology and Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/hep.30792DOI Listing
May 2019

Impaired Hepatic Phosphatidylcholine Synthesis Leads to Cholestasis in Mice Challenged With a High-Fat Diet.

Hepatol Commun 2019 Feb 2;3(2):262-276. Epub 2019 Jan 2.

Group on the Molecular and Cell Biology of Lipids and Department of Biochemistry University of Alberta Edmonton Canada.

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http://doi.wiley.com/10.1002/hep4.1302
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http://dx.doi.org/10.1002/hep4.1302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357837PMC
February 2019

Intestinal de novo phosphatidylcholine synthesis is required for dietary lipid absorption and metabolic homeostasis.

J Lipid Res 2018 09 14;59(9):1695-1708. Epub 2018 Jul 14.

Group on the Molecular and Cell Biology of Lipids University of Alberta, Edmonton, Alberta, Canada

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http://dx.doi.org/10.1194/jlr.M087056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121921PMC
September 2018

Pharmacomicrobiomics: a novel route towards personalized medicine?

Protein Cell 2018 05 28;9(5):432-445. Epub 2018 Apr 28.

Departments of Genetics, University Medical Center Groningen, PO Box 30001, 9700 RB, Groningen, The Netherlands.

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http://dx.doi.org/10.1007/s13238-018-0547-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960471PMC
May 2018

Cholesterol Transport Revisited: A New Turbo Mechanism to Drive Cholesterol Excretion.

Trends Endocrinol Metab 2018 02 21;29(2):123-133. Epub 2017 Dec 21.

Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Department of Vascular Medicine, University of Amsterdam Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.tem.2017.11.006DOI Listing
February 2018

ANGPTL4 promotes bile acid absorption during taurocholic acid supplementation via a mechanism dependent on the gut microbiota.

Biochim Biophys Acta Mol Cell Biol Lipids 2017 Oct 18;1862(10 Pt A):1056-1067. Epub 2017 Jul 18.

Nutrition, Metabolism and Genomics Group, Wageningen University, 6708 WE Wageningen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.bbalip.2017.07.005DOI Listing
October 2017

The art of quantifying glucose metabolism.

Am J Physiol Endocrinol Metab 2017 08;313(2):E257-E258

Departments of Pediatrics and Laboratory Medicine, University Medical Center Groningen, Groningen, The Netherlands

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http://dx.doi.org/10.1152/ajpendo.00066.2017DOI Listing
August 2017

An unexpected role for bile acid synthesis in adaptation to low temperature.

Nat Med 2017 07;23(7):800-802

Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands, and the Department of Vascular Medicine, University of Amsterdam, Academic Medical Center, Amsterdam, the Netherlands.

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http://www.nature.com/doifinder/10.1038/nm.4365
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http://dx.doi.org/10.1038/nm.4365DOI Listing
July 2017

Intestinal Farnesoid X Receptor Controls Transintestinal Cholesterol Excretion in Mice.

Gastroenterology 2017 04 5;152(5):1126-1138.e6. Epub 2017 Jan 5.

Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1053/j.gastro.2016.12.037DOI Listing
April 2017

Transintestinal and Biliary Cholesterol Secretion Both Contribute to Macrophage Reverse Cholesterol Transport in Rats-Brief Report.

Arterioscler Thromb Vasc Biol 2017 04 23;37(4):643-646. Epub 2017 Feb 23.

From the Departments of Pediatrics (J.F.d.B., M.S., A.D., M.K., R.H., F.K., U.J.F.T., A.K.G.) and Laboratory Medicine (F.K., A.K.G.), University of Groningen, University Medical Center Groningen, The Netherlands.

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https://www.ahajournals.org/doi/10.1161/ATVBAHA.116.308558
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http://dx.doi.org/10.1161/ATVBAHA.116.308558DOI Listing
April 2017

Reply to: "Impaired expression of multidrug resistance-associated protein 2 and liver damage in erythropoietic protoporphyria".

Hepatology 2016 May 21;63(5):1743-4. Epub 2015 Aug 21.

Department of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1002/hep.27993DOI Listing
May 2016

Nutrient Status Assessment in Individuals and Populations for Healthy Aging-Statement from an Expert Workshop.

Nutrients 2015 Dec 16;7(12):10491-500. Epub 2015 Dec 16.

Nutrition Science & Advocacy, DSM Nutritional Products Ltd., Wurmisweg 576, Kaiseraugst 4303, Switzerland.

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http://dx.doi.org/10.3390/nu7125547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4690099PMC
December 2015

Hepatic farnesoid X-receptor isoforms α2 and α4 differentially modulate bile salt and lipoprotein metabolism in mice.

PLoS One 2014 15;9(12):e115028. Epub 2014 Dec 15.

Department of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0115028PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266635PMC
November 2015

Gut microbiota inhibit Asbt-dependent intestinal bile acid reabsorption via Gata4.

J Hepatol 2015 Sep 27;63(3):697-704. Epub 2015 May 27.

Department of Pediatrics, Center for Liver, Digestive, and Metabolic Diseases, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; Department of Laboratory Medicine, Center for Liver, Digestive, and Metabolic Diseases, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2015.04.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5293168PMC
September 2015

A systems biology approach reveals the physiological origin of hepatic steatosis induced by liver X receptor activation.

FASEB J 2015 Apr 4;29(4):1153-64. Epub 2014 Dec 4.

Departments of *Pediatrics and Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands; Netherlands Consortium for Systems Biology, University of Amsterdam, Amsterdam, The Netherlands; Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands; and Groningen Centre for Systems Biology, University of Groningen, Groningen, The Netherlands

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http://dx.doi.org/10.1096/fj.14-254656DOI Listing
April 2015

New insights in the biology of ABC transporters ABCC2 and ABCC3: impact on drug disposition.

Expert Opin Drug Metab Toxicol 2015 Feb 7;11(2):273-93. Epub 2014 Nov 7.

University of Groningen, University Medical Center Groningen, Center for Liver, Digestive and Metabolic Diseases, Department of Pediatrics , Hanzeplein 1, 9713 GZ Groningen , The Netherlands

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http://dx.doi.org/10.1517/17425255.2015.981152DOI Listing
February 2015

Prednisolone increases enterohepatic cycling of bile acids by induction of Asbt and promotes reverse cholesterol transport.

J Hepatol 2014 Aug 26;61(2):351-7. Epub 2014 Mar 26.

University of Groningen, University Medical Center Groningen, Department of Pediatrics, Groningen, The Netherlands; Department of Laboratory Medicine, Groningen, The Netherlands.

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https://linkinghub.elsevier.com/retrieve/pii/S01688278140020
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http://dx.doi.org/10.1016/j.jhep.2014.03.025DOI Listing
August 2014

Beyond intestinal soap--bile acids in metabolic control.

Nat Rev Endocrinol 2014 Aug 13;10(8):488-98. Epub 2014 May 13.

Department of Pediatrics, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9700RB Groningen, Netherlands.

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http://www.nature.com/articles/nrendo.2014.60
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http://dx.doi.org/10.1038/nrendo.2014.60DOI Listing
August 2014

Cross-talk between liver and intestine in control of cholesterol and energy homeostasis.

Mol Aspects Med 2014 Jun 18;37:77-88. Epub 2014 Feb 18.

Departments of Pediatrics, University of Groningen, University Medical Center Groningen, The Netherlands.

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https://linkinghub.elsevier.com/retrieve/pii/S00982997140001
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http://dx.doi.org/10.1016/j.mam.2014.02.001DOI Listing
June 2014

FXR: the key to benefits in bariatric surgery?

Nat Med 2014 Apr;20(4):337-8

Departments of Pediatrics and Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1038/nm.3525DOI Listing
April 2014

Bile acid look-alike controls life span in C. elegans.

Cell Metab 2013 Aug;18(2):151-2

Departments of Pediatrics and Laboratory Medicine, University of Groningen, University Medical Center Groningen, The Netherlands.

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http://dx.doi.org/10.1016/j.cmet.2013.07.009DOI Listing
August 2013

Bile acid sequestration normalizes plasma cholesterol and reduces atherosclerosis in hypercholesterolemic mice. No additional effect of physical activity.

Atherosclerosis 2013 May 26;228(1):117-23. Epub 2013 Feb 26.

Department of Pediatrics, Center for Liver, Digestive, and Metabolic Diseases, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1016/j.atherosclerosis.2013.02.021DOI Listing
May 2013

Bile acids and cholestasis.

Gastroenterology 2013 Feb 21;144(2):e17-8. Epub 2012 Dec 21.

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http://dx.doi.org/10.1053/j.gastro.2012.10.053DOI Listing
February 2013

Stimulation of murine biliary cholesterol secretion by thyroid hormone is dependent on a functional ABCG5/G8 complex.

Hepatology 2012 Nov 14;56(5):1828-37. Epub 2012 Oct 14.

Department of Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden.

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http://dx.doi.org/10.1002/hep.25861DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533177PMC
November 2012

Chronic prednisolone treatment aggravates hyperglycemia in mice fed a high-fat diet but does not worsen dietary fat-induced insulin resistance.

Endocrinology 2012 Aug 31;153(8):3713-23. Epub 2012 May 31.

Department of Pediatrics, University of Groningen, University Medical Center Groningen, 9700 RB, Groningen, The Netherlands.

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http://dx.doi.org/10.1210/en.2011-1891DOI Listing
August 2012

Pharmacological LXR activation reduces presence of SR-B1 in liver membranes contributing to LXR-mediated induction of HDL-cholesterol.

Atherosclerosis 2012 Jun 3;222(2):382-9. Epub 2012 Mar 3.

Department of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1016/j.atherosclerosis.2012.02.014DOI Listing
June 2012

Treatment with high-dose simvastatin inhibits geranylgeranylation in AML blast cells in a subset of AML patients.

Exp Hematol 2012 Mar 25;40(3):177-186.e6. Epub 2011 Nov 25.

Department of Hematology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1016/j.exphem.2011.11.008DOI Listing
March 2012

Type I diabetes mellitus decreases in vivo macrophage-to-feces reverse cholesterol transport despite increased biliary sterol secretion in mice.

J Lipid Res 2012 Mar 18;53(3):348-57. Epub 2011 Dec 18.

Department of Pediatrics, Center for Liver, Digestive, and Metabolic Diseases, University Medical Center Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1194/jlr.M018671DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276458PMC
March 2012

Apolipoprotein CI knock-out mice display impaired memory functions.

J Alzheimers Dis 2011 ;23(4):737-47

Department of General Internal Medicine, Endocrinology and Metabolic Diseases, Leiden University Medical Center, TNO-Quality of Life, Gaubius Laboratory, The Netherlands.

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http://dx.doi.org/10.3233/JAD-2010-100576DOI Listing
December 2011

A reappraisal of the mechanism by which plant sterols promote neutral sterol loss in mice.

PLoS One 2011 30;6(6):e21576. Epub 2011 Jun 30.

Department of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0021576PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128081PMC
December 2011

Resistance to diet-induced adiposity in cannabinoid receptor-1 deficient mice is not due to impaired adipocyte function.

Nutr Metab (Lond) 2011 Dec 27;8:93. Epub 2011 Dec 27.

Center for Behavior and Neurosciences, Unit Neuroendocrinology, University of Groningen, Nijenborgh 7, 9747 AG Groningen, The Netherlands.

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http://dx.doi.org/10.1186/1743-7075-8-93DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307495PMC
December 2011

Voluntary wheel running increases bile acid as well as cholesterol excretion and decreases atherosclerosis in hypercholesterolemic mice.

Atherosclerosis 2011 Oct 12;218(2):323-9. Epub 2011 Jul 12.

Department of Pediatrics, University of Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1016/j.atherosclerosis.2011.06.040DOI Listing
October 2011

Reverse cholesterol transport revisited: contribution of biliary versus intestinal cholesterol excretion.

Arterioscler Thromb Vasc Biol 2011 Aug 12;31(8):1726-33. Epub 2011 May 12.

Department of Pediatrics, University Medical Center Groningen, University of Groningen, The Netherlands.

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http://dx.doi.org/10.1161/ATVBAHA.108.181206DOI Listing
August 2011

Liver receptor homolog-1 is critical for adequate up-regulation of Cyp7a1 gene transcription and bile salt synthesis during bile salt sequestration.

Hepatology 2011 Jun;53(6):2075-85

Department of Pediatrics, Center for Liver, Digestive, and Metabolic Diseases, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1002/hep.24286DOI Listing
June 2011

The liver X receptor: control of cellular lipid homeostasis and beyond Implications for drug design.

Prog Lipid Res 2010 Oct 2;49(4):343-52. Epub 2010 Apr 2.

Department of Pediatrics, Center for Liver Digestive and Metabolic Diseases, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1016/j.plipres.2010.03.002DOI Listing
October 2010

Intestinal FXR-mediated FGF15 production contributes to diurnal control of hepatic bile acid synthesis in mice.

Lab Invest 2010 Oct 7;90(10):1457-67. Epub 2010 Jun 7.

Department of Pediatrics, Center for Liver, Digestive and Metabolic Diseases, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1038/labinvest.2010.107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6643294PMC
October 2010

Activation of liver X receptors with T0901317 attenuates cardiac hypertrophy in vivo.

Eur J Heart Fail 2010 Oct 29;12(10):1042-50. Epub 2010 Jun 29.

Department of Experimental Cardiology, University Medical Center Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands.

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http://dx.doi.org/10.1093/eurjhf/hfq109DOI Listing
October 2010

Improved glycemic control with colesevelam treatment in patients with type 2 diabetes is not directly associated with changes in bile acid metabolism.

Hepatology 2010 Oct;52(4):1455-64

Department of Pediatrics, Center for Liver, Digestive and Metabolic Diseases, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1002/hep.23831DOI Listing
October 2010

Two time-point assessment of bile acid kinetics in humans using stable isotopes.

Isotopes Environ Health Stud 2010 Sep;46(3):325-36

Department of Laboratory Medicine, University Medical Center, Groningen, The Netherlands.

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http://dx.doi.org/10.1080/10256016.2010.503894DOI Listing
September 2010

Plasma bile acids are not associated with energy metabolism in humans.

Nutr Metab (Lond) 2010 Sep 3;7:73. Epub 2010 Sep 3.

Dept. of Pediatrics, Center for Liver, Digestive and Metabolic Diseases, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands.

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http://dx.doi.org/10.1186/1743-7075-7-73DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2942888PMC
September 2010

Exercise enhances whole-body cholesterol turnover in mice.

Med Sci Sports Exerc 2010 Aug;42(8):1460-8

Department of Pediatrics, Center for Liver, Digestive, and Metabolic Diseases, University Medical Center Groningen, University of Groningen, The Netherlands.

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http://dx.doi.org/10.1249/MSS.0b013e3181cfcb02DOI Listing
August 2010

A role of the bile salt receptor FXR in atherosclerosis.

Arterioscler Thromb Vasc Biol 2010 Aug;30(8):1519-28

Laboratory of Pediatrics, Center for Liver, Digestive and Metabolic Diseases, University Medical Center Groningen, Hanzeplein 1, 9713 EZ Groningen, The Netherlands.

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http://dx.doi.org/10.1161/ATVBAHA.109.197897DOI Listing
August 2010

The effects of intrauterine malnutrition on maternal-fetal cholesterol transport and fetal lipid synthesis in mice.

Pediatr Res 2010 Jul;68(1):10-5

Department of Pediatrics, University Medical Center Groningen, University of Groningen, 9713 BN Groningen, The Netherlands.

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http://dx.doi.org/10.1203/PDR.0b013e3181e1219bDOI Listing
July 2010

Voluntary exercise increases cholesterol efflux but not macrophage reverse cholesterol transport in vivo in mice.

Nutr Metab (Lond) 2010 Jul 1;7:54. Epub 2010 Jul 1.

Department of Pediatrics, Center for Liver, Digestive and Metabolic Diseases, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1186/1743-7075-7-54DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2903598PMC
July 2010

Chronic prednisolone treatment reduces hepatic insulin sensitivity while perturbing the fed-to-fasting transition in mice.

Endocrinology 2010 May 25;151(5):2171-8. Epub 2010 Feb 25.

Department of Pediatrics, Center for Liver Digestive and Metabolic Diseases, University Medical Center Groningen, RB Groningen, The Netherlands.

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http://endo.endojournals.org/content/151/5/2171.full.pdf
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http://press.endocrine.org/doi/abs/10.1210/en.2009-1374
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http://dx.doi.org/10.1210/en.2009-1374DOI Listing
May 2010

Activation of liver X receptor-alpha reduces activation of the renal and cardiac renin-angiotensin-aldosterone system.

Lab Invest 2010 Apr 1;90(4):630-6. Epub 2010 Feb 1.

Department of Experimental Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

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http://www.nature.com/articles/labinvest20107
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http://dx.doi.org/10.1038/labinvest.2010.7DOI Listing
April 2010

Scavenger receptor BI facilitates hepatic very low density lipoprotein production in mice.

J Lipid Res 2010 Mar 1;51(3):544-53. Epub 2009 Sep 1.

Department of Pediatrics, Center for Liver, Digestive and Metabolic Diseases, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

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http://www.jlr.org/content/51/3/544.full.pdf
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http://www.jlr.org/cgi/doi/10.1194/jlr.M000844
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http://dx.doi.org/10.1194/jlr.M000844DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2817584PMC
March 2010

Bile salt sequestration induces hepatic de novo lipogenesis through farnesoid X receptor- and liver X receptor alpha-controlled metabolic pathways in mice.

Hepatology 2010 Mar;51(3):806-16

Department of Pediatrics, Center for Liver, Digestive, and Metabolic Diseases, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1002/hep.23408DOI Listing
March 2010

The liver X-receptor gene promoter is hypermethylated in a mouse model of prenatal protein restriction.

Am J Physiol Regul Integr Comp Physiol 2010 Feb 4;298(2):R275-82. Epub 2009 Nov 4.

Center for Liver, Digestive and Metabolic Diseases, Laboratory of Pediatrics, Univ. Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands.

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http://dx.doi.org/10.1152/ajpregu.00413.2009DOI Listing
February 2010

Reduced fecal sterol excretion in subjects with familial hypoalphalipoproteinemia.

Atherosclerosis 2009 Dec 18;207(2):614-6. Epub 2009 Jun 18.

Department of Vascular Medicine, Academic Medical Centre, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.atherosclerosis.2009.06.022DOI Listing
December 2009

Fenofibrate simultaneously induces hepatic fatty acid oxidation, synthesis, and elongation in mice.

J Biol Chem 2009 Dec 2;284(49):34036-44. Epub 2009 Oct 2.

Department of Pediatrics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.

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http://dx.doi.org/10.1074/jbc.M109.051052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797174PMC
December 2009

Developments in bile acid kinetic measurements using (13)C and (2)H: 10(5) times improved sensitivity during the last 40 years.

Isotopes Environ Health Stud 2009 Dec;45(4):275-88

Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1080/10256010903356888DOI Listing
December 2009

Fetal liver X receptor activation acutely induces lipogenesis but does not affect plasma lipid response to a high-fat diet in adult mice.

Am J Physiol Endocrinol Metab 2009 Nov 1;297(5):E1171-8. Epub 2009 Sep 1.

Dept. of Pediatrics, Univ. Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands.

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http://dx.doi.org/10.1152/ajpendo.00021.2009DOI Listing
November 2009

Scavenger receptor class B type I mediates biliary cholesterol secretion independent of ATP-binding cassette transporter g5/g8 in mice.

Hepatology 2009 Oct;50(4):1263-72

Department of Pediatrics, Center for Liver, Digestive and Metabolic Diseases, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1002/hep.23112DOI Listing
October 2009

Lack of Abcg1 results in decreased plasma HDL cholesterol levels and increased biliary cholesterol secretion in mice fed a high cholesterol diet.

Atherosclerosis 2009 Sep 11;206(1):141-7. Epub 2009 Mar 11.

Center for Liver, Digestive and Metabolic Diseases, Dept. of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1016/j.atherosclerosis.2009.02.022DOI Listing
September 2009

Hepatic SR-BI, not endothelial lipase, expression determines biliary cholesterol secretion in mice.

J Lipid Res 2009 Aug 28;50(8):1571-80. Epub 2009 Feb 28.

Center for Liver, Digestive and Metabolic Diseases, Department of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1194/jlr.M800434-JLR200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2724056PMC
August 2009

Activation of the liver X receptor stimulates trans-intestinal excretion of plasma cholesterol.

J Biol Chem 2009 Jul 5;284(29):19211-9. Epub 2009 May 5.

Department of Pediatrics, Center for Liver, Digestive, and Metabolic Diseases, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands.

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http://dx.doi.org/10.1074/jbc.M109.014860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2740545PMC
July 2009

Variability in responsiveness to lovastatin of the primitive CD34+ AML subfraction compared to normal CD34+ cells.

Ann Hematol 2009 Jun 11;88(6):573-80. Epub 2008 Nov 11.

Department of Hematology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1007/s00277-008-0633-2DOI Listing
June 2009

High fat feeding induces hepatic fatty acid elongation in mice.

PLoS One 2009 Jun 26;4(6):e6066. Epub 2009 Jun 26.

Department of Pediatrics, Center for Liver Digestive and Metabolic Diseases, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0006066PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699051PMC
June 2009

An increased flux through the glucose 6-phosphate pool in enterocytes delays glucose absorption in Fxr-/- mice.

J Biol Chem 2009 Apr 9;284(16):10315-23. Epub 2009 Feb 9.

Departments of Laboratory Medicine and Pediatrics, Center for Liver Digestive and Metabolic Diseases, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.

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http://dx.doi.org/10.1074/jbc.M807317200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2667718PMC
April 2009

Association of plasma phytosterol concentrations with incident coronary heart disease Data from the CORA study, a case-control study of coronary artery disease in women.

Atherosclerosis 2009 Mar 26;203(1):284-90. Epub 2008 Jun 26.

Division of Endocrinology and Metabolism of Ageing, University Hospital Hamburg-Eppendorf, Germany.

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http://dx.doi.org/10.1016/j.atherosclerosis.2008.06.014DOI Listing
March 2009

Altered bile composition after liver transplantation is associated with the development of nonanastomotic biliary strictures.

J Hepatol 2009 Jan 7;50(1):69-79. Epub 2008 Oct 7.

Section of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands.

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http://dx.doi.org/10.1016/j.jhep.2008.07.032DOI Listing
January 2009

Low retinol levels differentially modulate bile salt-induced expression of human and mouse hepatic bile salt transporters.

Hepatology 2009 Jan;49(1):151-9

Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1002/hep.22661DOI Listing
January 2009

Nuclear receptors: mediators and modifiers of inflammation-induced cholestasis.

Front Biosci (Landmark Ed) 2009 Jan 1;14:2599-630. Epub 2009 Jan 1.

Department of Pediatrics Center for Liver, Digestive and Metabolic Diseases, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4085779PMC
http://dx.doi.org/10.2741/3400DOI Listing
January 2009

Lxralpha deficiency hampers the hepatic adaptive response to fasting in mice.

J Biol Chem 2008 Sep 8;283(37):25437-45. Epub 2008 Jul 8.

Departments of Pediatrics and Laboratory Medicine, Center for Liver Digestive and Metabolic Diseases, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1074/jbc.M801922200DOI Listing
September 2008

Chipping away at gallstones.

Nat Med 2008 Jul;14(7):715-6

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http://www.nature.com/articles/nm0708-715
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http://dx.doi.org/10.1038/nm0708-715DOI Listing
July 2008