Floris Imhann

Floris Imhann

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Floris Imhann

Floris Imhann

Publications by authors named "Floris Imhann"

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SLC39A8 missense variant is associated with Crohn's disease but does not have a major impact on gut microbiome composition in healthy subjects.

Authors:
Valerie Collij Floris Imhann Arnau Vich Vila Jingyuan Fu Gerard Dijkstra Eleonora A M Festen Michiel D Voskuil Mark J Daly Ramnik J Xavier Cisca Wijmenga Alexandra Zhernakova Rinse K Weersma

PLoS One 2019 31;14(1):e0211328. Epub 2019 Jan 31.

Department of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, RB, Groningen, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211328PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354981PMC
October 2019

Anti-inflammatory Gut Microbial Pathways Are Decreased During Crohn's Disease Exacerbations.

Authors:
Marjolein A Y Klaassen Floris Imhann Valerie Collij Jingyuan Fu Cisca Wijmenga Alexandra Zhernakova Gerard Dijkstra Eleonora A M Festen Ranko Gacesa Arnau Vich Vila Rinse K Weersma

J Crohns Colitis 2019 Oct;13(11):1439-1449

University Medical Center Groningen, Department of Gastroenterology and Hepatology, Groningen, The Netherlands.

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http://dx.doi.org/10.1093/ecco-jcc/jjz077DOI Listing
October 2019

Author Correction: Gut microbiome structure and metabolic activity in inflammatory bowel disease.

Authors:
Eric A Franzosa Alexandra Sirota-Madi Julian Avila-Pacheco Nadine Fornelos Henry J Haiser Stefan Reinker Tommi Vatanen A Brantley Hall Himel Mallick Lauren J McIver Jenny S Sauk Robin G Wilson Betsy W Stevens Justin M Scott Kerry Pierce Amy A Deik Kevin Bullock Floris Imhann Jeffrey A Porter Alexandra Zhernakova Jingyuan Fu Rinse K Weersma Cisca Wijmenga Clary B Clish Hera Vlamakis Curtis Huttenhower Ramnik J Xavier

Nat Microbiol 2019 May;4(5):898

Broad Institute of MIT and Harvard, Cambridge, MA, USA.

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http://dx.doi.org/10.1038/s41564-019-0442-5DOI Listing
May 2019

MOLGENIS research: advanced bioinformatics data software for non-bioinformaticians.

Authors:
K Joeri van der Velde Floris Imhann Bart Charbon Chao Pang David van Enckevort Mariska Slofstra Ruggero Barbieri Rudi Alberts Dennis Hendriksen Fleur Kelpin Mark de Haan Tommy de Boer Sido Haakma Connor Stroomberg Salome Scholtens Gert-Jan van de Geijn Eleonora A M Festen Rinse K Weersma Morris A Swertz

Bioinformatics 2019 Mar;35(6):1076-1078

Genomics Coordination Center, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands.

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https://academic.oup.com/bioinformatics/advance-article/doi/
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http://dx.doi.org/10.1093/bioinformatics/bty742DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419911PMC
March 2019

Genetic effects on the commensal microbiota in inflammatory bowel disease patients.

Authors:
Hugues Aschard Vincent Laville Eric Tchetgen Tchetgen Dan Knights Floris Imhann Philippe Seksik Noah Zaitlen Mark S Silverberg Jacques Cosnes Rinse K Weersma Ramnik Xavier Laurent Beaugerie David Skurnik Harry Sokol

PLoS Genet 2019 03 8;15(3):e1008018. Epub 2019 Mar 8.

Department of Gastroenterology, Saint Antoine Hospital, Paris, France.

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http://dx.doi.org/10.1371/journal.pgen.1008018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426259PMC
March 2019

Correction to: The 1000IBD project: multi-omics data of 1000 inflammatory bowel disease patients; data release 1.

Authors:
Floris Imhann K J Van der Velde R Barbieri R Alberts M D Voskuil A Vich Vila V Collij L M Spekhorst K W J Van der Sloot V Peters H M Van Dullemen M C Visschedijk E A M Festen M A Swertz G Dijkstra R K Weersma

BMC Gastroenterol 2019 03 27;19(1):44. Epub 2019 Mar 27.

Department of Gastroenterology and Hepatology, University of Groningen and University Medical Center Groningen, PO Box 30.001, 9700RB, Groningen, the Netherlands.

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http://dx.doi.org/10.1186/s12876-019-0938-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436211PMC
March 2019

Gut microbiome structure and metabolic activity in inflammatory bowel disease.

Authors:
Eric A Franzosa Alexandra Sirota-Madi Julian Avila-Pacheco Nadine Fornelos Henry J Haiser Stefan Reinker Tommi Vatanen A Brantley Hall Himel Mallick Lauren J McIver Jenny S Sauk Robin G Wilson Betsy W Stevens Justin M Scott Kerry Pierce Amy A Deik Kevin Bullock Floris Imhann Jeffrey A Porter Alexandra Zhernakova Jingyuan Fu Rinse K Weersma Cisca Wijmenga Clary B Clish Hera Vlamakis Curtis Huttenhower Ramnik J Xavier

Nat Microbiol 2019 02 10;4(2):293-305. Epub 2018 Dec 10.

Broad Institute of MIT and Harvard, Cambridge, MA, USA.

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http://www.nature.com/articles/s41564-018-0306-4
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http://dx.doi.org/10.1038/s41564-018-0306-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342642PMC
February 2019

The 1000IBD project: multi-omics data of 1000 inflammatory bowel disease patients; data release 1.

Authors:
Floris Imhann K J Van der Velde R Barbieri R Alberts M D Voskuil A Vich Vila V Collij L M Spekhorst K W J Van der Sloot V Peters H M Van Dullemen M C Visschedijk E A M Festen M A Swertz G Dijkstra R K Weersma

BMC Gastroenterol 2019 Jan 8;19(1). Epub 2019 Jan 8.

Department of Gastroenterology and Hepatology, University of Groningen and University Medical Center Groningen, PO Box 30.001, 9700RB, Groningen, the Netherlands.

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https://bmcgastroenterol.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/s12876-018-0917-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325838PMC
January 2019

Gut microbiota composition and functional changes in inflammatory bowel disease and irritable bowel syndrome.

Authors:
Arnau Vich Vila Floris Imhann Valerie Collij Soesma A Jankipersadsing Thomas Gurry Zlatan Mujagic Alexander Kurilshikov Marc Jan Bonder Xiaofang Jiang Ettje F Tigchelaar Jackie Dekens Vera Peters Michiel D Voskuil Marijn C Visschedijk Hendrik M van Dullemen Daniel Keszthelyi Morris A Swertz Lude Franke Rudi Alberts Eleonora A M Festen Gerard Dijkstra Ad A M Masclee Marten H Hofker Ramnik J Xavier Eric J Alm Jingyuan Fu Cisca Wijmenga Daisy M A E Jonkers Alexandra Zhernakova Rinse K Weersma

Sci Transl Med 2018 12;10(472)

University of Groningen and University Medical Center Groningen, Department of Gastroenterology and Hepatology, Groningen, Netherlands.

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http://dx.doi.org/10.1126/scitranslmed.aap8914DOI Listing
December 2018

Analysis of 1135 gut metagenomes identifies sex-specific resistome profiles.

Authors:
Trishla Sinha Arnau Vich Vila Sanzhima Garmaeva Soesma A Jankipersadsing Floris Imhann Valerie Collij Marc Jan Bonder Xiaofang Jiang Thomas Gurry Eric J Alm Mauro D'Amato Rinse K Weersma Sicco Scherjon Cisca Wijmenga Jingyuan Fu Alexander Kurilshikov Alexandra Zhernakova

Gut Microbes 2019 29;10(3):358-366. Epub 2018 Oct 29.

a Department of Genetics , University of Groningen, University Medical Center Groningen , Groningen , the Netherlands.

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https://www.tandfonline.com/doi/full/10.1080/19490976.2018.1
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http://dx.doi.org/10.1080/19490976.2018.1528822DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6546312PMC
October 2018

Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis.

Authors:
Rudi Alberts Elisabeth M G de Vries Elizabeth C Goode Xiaojun Jiang Fotis Sampaziotis Krista Rombouts Katrin Böttcher Trine Folseraas Tobias J Weismüller Andrew L Mason Weiwei Wang Graeme Alexander Domenico Alvaro Annika Bergquist Niklas K Björkström Ulrich Beuers Einar Björnsson Kirsten Muri Boberg Christopher L Bowlus Maria C Bragazzi Marco Carbone Olivier Chazouillères Angela Cheung Georgios Dalekos John Eaton Bertus Eksteen David Ellinghaus Martti Färkkilä Eleonora A M Festen Annarosa Floreani Irene Franceschet Daniel Nils Gotthardt Gideon M Hirschfield Bart van Hoek Kristian Holm Simon Hohenester Johannes Roksund Hov Floris Imhann Pietro Invernizzi Brian D Juran Henrike Lenzen Wolfgang Lieb Jimmy Z Liu Hanns-Ulrich Marschall Marco Marzioni Espen Melum Piotr Milkiewicz Tobias Müller Albert Pares Christian Rupp Christian Rust Richard N Sandford Christoph Schramm Stefan Schreiber Erik Schrumpf Mark S Silverberg Brijesh Srivastava Martina Sterneck Andreas Teufel Ludovic Vallier Joanne Verheij Arnau Vich Vila Boudewijn de Vries Kalliopi Zachou Roger W Chapman Michael P Manns Massimo Pinzani Simon M Rushbrook Konstantinos N Lazaridis Andre Franke Carl A Anderson Tom H Karlsen Cyriel Y Ponsioen Rinse K Weersma

Gut 2018 08 4;67(8):1517-1524. Epub 2017 Aug 4.

Department of Gastroenterology and Hepatology, University of Groningen and University Medical Centre Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1136/gutjnl-2016-313598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797498PMC
August 2018

Genomic and Expression Analyses Identify a Disease-Modifying Variant for Fibrostenotic Crohn's Disease.

Authors:
Marijn C Visschedijk Lieke M Spekhorst Shih-Chin Cheng Ellen S van Loo B H Dianne Jansen Tjasso Blokzijl Hyunsuk Kil Dirk J de Jong Marieke Pierik Jeroen P W J Maljaars C Janneke van der Woude Adriaan A van Bodegraven Bas Oldenburg Mark Löwenberg Vincent B Nieuwenhuijs Floris Imhann Suzanne van Sommeren Rudi Alberts Ramnik J Xavier Gerard Dijkstra Klaas Nico Faber C Marcelo Aldaz Rinse K Weersma Eleonora A M Festen

J Crohns Colitis 2018 04;12(5):582-588

Department of Gastroenterology and Hepatology, University of Groningen and University Medical Centre Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1093/ecco-jcc/jjy001DOI Listing
April 2018

Interplay of host genetics and gut microbiota underlying the onset and clinical presentation of inflammatory bowel disease.

Authors:
Floris Imhann Arnau Vich Vila Marc Jan Bonder Jingyuan Fu Dirk Gevers Marijn C Visschedijk Lieke M Spekhorst Rudi Alberts Lude Franke Hendrik M van Dullemen Rinze W F Ter Steege Curtis Huttenhower Gerard Dijkstra Ramnik J Xavier Eleonora A M Festen Cisca Wijmenga Alexandra Zhernakova Rinse K Weersma

Gut 2018 01 8;67(1):108-119. Epub 2016 Oct 8.

Department of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1136/gutjnl-2016-312135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5699972PMC
January 2018

Prevalence of- and risk factors for work disability in Dutch patients with inflammatory bowel disease.

Authors:
Lieke M Spekhorst Bas Oldenburg Ad A van Bodegraven Dirk J de Jong Floris Imhann Andrea E van der Meulen-de Jong Marieke J Pierik Janneke C van der Woude Gerard Dijkstra Geert D'Haens Mark Löwenberg Rinse K Weersma Eleonora A M Festen

World J Gastroenterol 2017 Dec;23(46):8182-8192

Department of Gastroenterology and Hepatology, University of Groningen and University Medical Centre Groningen, Groningen, 9700 RB Groningen, the Netherlands.

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http://dx.doi.org/10.3748/wjg.v23.i46.8182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739924PMC
December 2017

Cohort profile: design and first results of the Dutch IBD Biobank: a prospective, nationwide biobank of patients with inflammatory bowel disease.

Authors:
Lieke M Spekhorst Floris Imhann Eleonora A M Festen Ad A van Bodegraven Nanne K H de Boer Gerd Bouma Herma H Fidder Geert d'Haens Frank Hoentjen Daan W Hommes Dirk J de Jong Mark Löwenberg P W Jeroen Maljaars Andrea E van der Meulen-de Jong Bas Oldenburg Marieke J Pierik Cyriel Y Ponsioen Pieter C Stokkers Hein W Verspaget Marijn C Visschedijk C Janneke van der Woude Gerard Dijkstra Rinse K Weersma

BMJ Open 2017 11 8;7(11):e016695. Epub 2017 Nov 8.

Department of Gastroenterology and Hepatology, University of Groningen and Medical Center Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1136/bmjopen-2017-016695DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5695377PMC
November 2017

Pooled Resequencing of 122 Ulcerative Colitis Genes in a Large Dutch Cohort Suggests Population-Specific Associations of Rare Variants in MUC2.

Authors:
Marijn C Visschedijk Rudi Alberts Soren Mucha Patrick Deelen Dirk J de Jong Marieke Pierik Lieke M Spekhorst Floris Imhann Andrea E van der Meulen-de Jong C Janneke van der Woude Adriaan A van Bodegraven Bas Oldenburg Mark Löwenberg Gerard Dijkstra David Ellinghaus Stefan Schreiber Cisca Wijmenga Manuel A Rivas Andre Franke Cleo C van Diemen Rinse K Weersma

PLoS One 2016 4;11(8):e0159609. Epub 2016 Aug 4.

Department of Gastroenterology and Hepatology, University of Groningen, University Medical Centre Groningen, 9700 RB, Groningen, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0159609PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973970PMC
August 2017

The influence of proton pump inhibitors and other commonly used medication on the gut microbiota.

Authors:
Floris Imhann Arnau Vich Vila Marc Jan Bonder Ailine G Lopez Manosalva Debby P Y Koonen Jingyuan Fu Cisca Wijmenga Alexandra Zhernakova Rinse K Weersma

Gut Microbes 2017 07 24;8(4):351-358. Epub 2017 Jan 24.

a University of Groningen and University Medical Center Groningen , Department of Gastroenterology and Hepatology , Groningen , the Netherlands.

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http://dx.doi.org/10.1080/19490976.2017.1284732DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570416PMC
July 2017

The effect of host genetics on the gut microbiome.

Authors:
Marc Jan Bonder Alexander Kurilshikov Ettje F Tigchelaar Zlatan Mujagic Floris Imhann Arnau Vich Vila Patrick Deelen Tommi Vatanen Melanie Schirmer Sanne P Smeekens Daria V Zhernakova Soesma A Jankipersadsing Martin Jaeger Marije Oosting Maria Carmen Cenit Ad A M Masclee Morris A Swertz Yang Li Vinod Kumar Leo Joosten Hermie Harmsen Rinse K Weersma Lude Franke Marten H Hofker Ramnik J Xavier Daisy Jonkers Mihai G Netea Cisca Wijmenga Jingyuan Fu Alexandra Zhernakova

Nat Genet 2016 11 3;48(11):1407-1412. Epub 2016 Oct 3.

University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, the Netherlands.

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http://dx.doi.org/10.1038/ng.3663DOI Listing
November 2016

Proton pump inhibitors affect the gut microbiome.

Authors:
Floris Imhann Marc Jan Bonder Arnau Vich Vila Jingyuan Fu Zlatan Mujagic Lisa Vork Ettje F Tigchelaar Soesma A Jankipersadsing Maria Carmen Cenit Hermie J M Harmsen Gerard Dijkstra Lude Franke Ramnik J Xavier Daisy Jonkers Cisca Wijmenga Rinse K Weersma Alexandra Zhernakova

Gut 2016 May 9;65(5):740-8. Epub 2015 Dec 9.

University of Groningen and University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands.

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http://dx.doi.org/10.1136/gutjnl-2015-310376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853569PMC
May 2016

HSPA6 is an ulcerative colitis susceptibility factor that is induced by cigarette smoke and protects intestinal epithelial cells by stabilizing anti-apoptotic Bcl-XL.

Authors:
Anouk Regeling Floris Imhann Haukeline H Volders Tjasso Blokzijl Vincent W Bloks Rinse K Weersma Gerard Dijkstra Klaas Nico Faber

Biochim Biophys Acta 2016 04 26;1862(4):788-796. Epub 2016 Jan 26.

Department of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2016.01.020DOI Listing
April 2016

Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity.

Authors:
Alexandra Zhernakova Alexander Kurilshikov Marc Jan Bonder Ettje F Tigchelaar Melanie Schirmer Tommi Vatanen Zlatan Mujagic Arnau Vich Vila Gwen Falony Sara Vieira-Silva Jun Wang Floris Imhann Eelke Brandsma Soesma A Jankipersadsing Marie Joossens Maria Carmen Cenit Patrick Deelen Morris A Swertz Rinse K Weersma Edith J M Feskens Mihai G Netea Dirk Gevers Daisy Jonkers Lude Franke Yurii S Aulchenko Curtis Huttenhower Jeroen Raes Marten H Hofker Ramnik J Xavier Cisca Wijmenga Jingyuan Fu

Science 2016 Apr 28;352(6285):565-9. Epub 2016 Apr 28.

University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, Netherlands. University of Groningen, University Medical Center Groningen, Department of Pediatrics, Groningen, Netherlands.

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http://dx.doi.org/10.1126/science.aad3369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5240844PMC
April 2016

The Gut Microbiome Contributes to a Substantial Proportion of the Variation in Blood Lipids.

Authors:
Jingyuan Fu Marc Jan Bonder María Carmen Cenit Ettje F Tigchelaar Astrid Maatman Jackie A M Dekens Eelke Brandsma Joanna Marczynska Floris Imhann Rinse K Weersma Lude Franke Tiffany W Poon Ramnik J Xavier Dirk Gevers Marten H Hofker Cisca Wijmenga Alexandra Zhernakova

Circ Res 2015 Oct 10;117(9):817-24. Epub 2015 Sep 10.

From the Department of Pediatrics (J.F., E.B., M.H.H.), Department of Genetics (J.F., M.J.B., M.C.C., E.F.T., A.M., J.A.M.D., J.M., L.F., C.W., A.Z.), and Department of Gastroenterology and Hepatology (F.I., R.K.W.), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Top Institute Food and Nutrition, Wageningen, The Netherlands (E.F.T., J.A.M.D., A.Z.); Department of Immunology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland (J.M.); Broad Institute of MIT and Harvard, Cambridge, MA (T.W.P., R.J.X., D.G.); and Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease (R.J.X.) and Center for Computational and Integrative Biology (R.J.X.), Massachusetts General Hospital and Harvard Medical School, Boston.

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http://dx.doi.org/10.1161/CIRCRESAHA.115.306807DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596485PMC
October 2015

Complex host genetics influence the microbiome in inflammatory bowel disease.

Authors:
Dan Knights Mark S Silverberg Rinse K Weersma Dirk Gevers Gerard Dijkstra Hailiang Huang Andrea D Tyler Suzanne van Sommeren Floris Imhann Joanne M Stempak Hu Huang Pajau Vangay Gabriel A Al-Ghalith Caitlin Russell Jenny Sauk Jo Knight Mark J Daly Curtis Huttenhower Ramnik J Xavier

Genome Med 2014 2;6(12):107. Epub 2014 Dec 2.

Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142 USA ; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114 USA ; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114 USA.

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http://dx.doi.org/10.1186/s13073-014-0107-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4292994PMC
January 2015