Florian Singer

Florian Singer

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Ventilation and perfusion assessed by functional MRI in children with CF: reproducibility in comparison to lung function.

J Cyst Fibros 2019 Jul 20;18(4):543-550. Epub 2018 Oct 20.

Pediatric Respiratory Medicine, Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Switzerland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15691993183085
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http://dx.doi.org/10.1016/j.jcf.2018.10.003DOI Listing
July 2019

An innovative lung model for multiple breath washout testing in health and disease.

Clin Biomech (Bristol, Avon) 2019 Jun 10;66:74-80. Epub 2017 Nov 10.

ARTORG Center for Biomedical Engineering Research, University of Bern, Bern, Switzerland.

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http://dx.doi.org/10.1016/j.clinbiomech.2017.11.002DOI Listing
June 2019

Respiratory rate in infants with cystic fibrosis throughout the first year of life and association with lung clearance index measured shortly after birth.

J Cyst Fibros 2019 Jan 27;18(1):118-126. Epub 2018 Jul 27.

Paediatric Respiratory Medicine, Inselspital, University Children's Hospital of Bern, University of Bern, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.jcf.2018.07.002DOI Listing
January 2019

Alternate gas washout indices: Assessment of ventilation inhomogeneity in mild to moderate pediatric cystic fibrosis lung disease.

Pediatr Pulmonol 2018 11 30;53(11):1485-1491. Epub 2018 Aug 30.

Division of Paediatric Pulmonology, University Children's Hospital Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1002/ppul.24149DOI Listing
November 2018

Obstructive Sleep Apnoea in Children and Adolescents with Ehlers-Danlos Syndrome.

Respiration 2019 28;97(4):284-291. Epub 2018 Nov 28.

Department of Pulmonology, University Hospital Zurich, Zurich, Switzerland,

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https://www.karger.com/Article/FullText/494328
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http://dx.doi.org/10.1159/000494328DOI Listing
November 2018

Monitoring pulmonary health in Swiss childhood cancer survivors.

Pediatr Blood Cancer 2018 10 15;65(10):e27255. Epub 2018 Jun 15.

Swiss Childhood Cancer Registry, Institute of Social and Preventive Medicine, University of Bern, Switzerland.

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http://doi.wiley.com/10.1002/pbc.27255
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http://dx.doi.org/10.1002/pbc.27255DOI Listing
October 2018

Effect of intermittent inspiratory leaks on measurement of lung clearance index using nitrogen and sulfur hexafluoride.

ERJ Open Res 2018 Oct 19;4(4). Epub 2018 Oct 19.

Division of Respiratory Medicine, Dept of Paediatrics, University Hospital of Bern, University of Bern, Bern, Switzerland.

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http://dx.doi.org/10.1183/23120541.00140-2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194201PMC
October 2018

Multiple breath washout: A new and promising lung function test for patients with idiopathic pulmonary fibrosis.

Respirology 2018 08 24;23(8):764-770. Epub 2018 Mar 24.

Department of Pulmonary Medicine, Bern University Hospital, University of Bern, Bern, Switzerland.

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http://dx.doi.org/10.1111/resp.13294DOI Listing
August 2018

Short-Term Effects of Elastic Chest Wall Restriction on Pulmonary Function in Children with Cystic Fibrosis.

Respiration 2018;96(6):535-542. Epub 2018 Aug 21.

Division of Respiratory Medicine, Department of Paediatrics, University Hospital of Bern, University of Bern, Bern,

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https://www.karger.com/Article/FullText/491094
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http://dx.doi.org/10.1159/000491094DOI Listing
August 2018

Inert Gas Washout in Bronchiolitis Obliterans Following Hematopoietic Cell Transplantation.

Chest 2018 07 21;154(1):157-168. Epub 2017 Dec 21.

Clinic of Pulmonary Medicine and Respiratory Cell Research, University Hospital Basel, Basel, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.chest.2017.12.009DOI Listing
July 2018

Comparison of different analysis algorithms to calculate multiple-breath washout outcomes.

ERJ Open Res 2018 Jul 13;4(3). Epub 2018 Jul 13.

Pediatric Respiratory Medicine, Dept of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

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http://dx.doi.org/10.1183/23120541.00021-2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043724PMC
July 2018

Inert gas washout: background and application in various lung diseases.

Swiss Med Wkly 2017 16;147:w14483. Epub 2017 Aug 16.

Division of Respiratory Medicine, Department of Paediatrics, Inselspital, Bern University Hospital, University of Bern, Switzerland.

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http://dx.doi.org/10.4414/smw.2017.14483DOI Listing
June 2018

Infant multiple breath washout using a new commercially available device: Ready to replace the previous setup?

Pediatr Pulmonol 2018 05 8;53(5):628-635. Epub 2018 Feb 8.

Pediatric Respiratory Medicine, Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

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http://dx.doi.org/10.1002/ppul.23959DOI Listing
May 2018

Lower exhaled nitric oxide in infants with Cystic Fibrosis compared to healthy controls.

J Cyst Fibros 2018 01 14;17(1):105-108. Epub 2017 Jul 14.

Paediatric Respiratory Medicine, Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.jcf.2017.05.005DOI Listing
January 2018

Leaks during multiple-breath washout: characterisation and influence on outcomes.

ERJ Open Res 2018 Jan 23;4(1). Epub 2018 Feb 23.

Pediatric Respiratory Medicine, Dept of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

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http://dx.doi.org/10.1183/23120541.00012-2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827412PMC
January 2018

Novel magnetic resonance technique for functional imaging of cystic fibrosis lung disease.

Eur Respir J 2017 Dec 7;50(6). Epub 2017 Dec 7.

Pediatric Respiratory Medicine, Dept of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland

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http://dx.doi.org/10.1183/13993003.01464-2017DOI Listing
December 2017

A simple method to reconstruct the molar mass signal of respiratory gas to assess small airways with a double-tracer gas single-breath washout.

Med Biol Eng Comput 2017 Nov 29;55(11):1975-1987. Epub 2017 Mar 29.

Klinik Schillerhöhe, Zentrum für Pneumologie und Thoraxchirurgie, Robert-Bosch-Hospital, Gerlingen, Germany.

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http://dx.doi.org/10.1007/s11517-017-1633-yDOI Listing
November 2017

Elevated lung clearance index in infants with cystic fibrosis shortly after birth.

Eur Respir J 2017 11 9;50(5). Epub 2017 Nov 9.

Paediatric Respiratory Medicine, Inselspital, University Children's Hospital of Bern, University of Bern, Bern, Switzerland

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http://dx.doi.org/10.1183/13993003.00580-2017DOI Listing
November 2017

Unexpected results in infant multiple breath washout: Is the truth hidden in the washin?

Pediatr Pulmonol 2017 06 5;52(6):717-719. Epub 2017 May 5.

Pediatric Respiratory Medicine, Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

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http://dx.doi.org/10.1002/ppul.23655DOI Listing
June 2017

Agreement between multiple-breath nitrogen washout systems in children and adults.

J Cyst Fibros 2017 Mar 3;16(2):258-266. Epub 2016 Dec 3.

Cystic Fibrosis Unit, Cliniques Universitaires St Luc, Université de Louvain, Avenue Hippocrate 10, 1200 Brussels, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.jcf.2016.11.004DOI Listing
March 2017

Changes in minute ventilation after exposure to 4% sulfur hexafluoride (SF ) in infants.

Pediatr Pulmonol 2017 02 2;52(2):151-153. Epub 2016 Sep 2.

Department of Pediatrics, University of Basel Children's Hospital (UKBB), Basel, Switzerland.

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http://dx.doi.org/10.1002/ppul.23557DOI Listing
February 2017

Alternative inert gas washout outcomes in patients with primary ciliary dyskinesia.

Eur Respir J 2017 01 25;49(1). Epub 2017 Jan 25.

Dept of Paediatric Pulmonology, University Children's Hospital of Ruhr University Bochum at St. Josef-Hospital, Bochum, Germany

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http://dx.doi.org/10.1183/13993003.00466-2016DOI Listing
January 2017

Lung clearance index and moment ratios at different cut-off values in infant multiple-breath washout measurements.

Pediatr Pulmonol 2016 12 23;51(12):1373-1381. Epub 2016 May 23.

Department of Pediatrics, University of Basel Children's Hospital (UKBB), Spitalstrasse 33, Basel 4031, Switzerland.

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http://dx.doi.org/10.1002/ppul.23483DOI Listing
December 2016

Feasibility of nitrogen multiple-breath washout in inexperienced children younger than 7 years.

Pediatr Pulmonol 2016 11 1;51(11):1183-1190. Epub 2016 May 1.

University Children's Hospital Basel, UKBB, Basel, 4031, Switzerland.

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http://dx.doi.org/10.1002/ppul.23431DOI Listing
November 2016

Physiological phenotyping of pediatric chronic obstructive airway diseases.

J Appl Physiol (1985) 2016 07 26;121(1):324-32. Epub 2016 May 26.

Division of Respiratory Medicine, Department of Paediatrics, University Children's Hospital of Bern, University of Bern, Bern, Switzerland; Department of Paediatric Pulmonology, University Children's Hospital Basel (UKBB), Basel, Switzerland;

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http://dx.doi.org/10.1152/japplphysiol.00086.2016DOI Listing
July 2016

Impact of Software Settings on Multiple-Breath Washout Outcomes.

PLoS One 2015 13;10(7):e0132250. Epub 2015 Jul 13.

University Children's Hospital Basel, UKBB, 4031, Basel, Switzerland; University Children's Hospital Bern, 3010, Bern, Switzerland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0132250PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500401PMC
May 2016

CFTR modulation for young children with cystic fibrosis.

Lancet Respir Med 2016 Feb 21;4(2):84-5. Epub 2016 Jan 21.

University Children's Hospital Bern, Bern, Switzerland; University Children's Hospital Basel, UKBB, Spitalstrasse 33, 4031 Basel, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/S2213-2600(16)00009-6DOI Listing
February 2016

Functional evidence for continued alveolarisation in former preterms at school age?

Eur Respir J 2016 Jan 22;47(1):147-55. Epub 2015 Oct 22.

University Children's Hospital of Basel (UKBB), Basel, Switzerland Division of Respiratory Medicine, Department of Paediatrics, University Children's Hospital Bern, Bern, Switzerland

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http://erj.ersjournals.com/content/early/2015/10/22/13993003
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http://erj.ersjournals.com/lookup/doi/10.1183/13993003.00478
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http://dx.doi.org/10.1183/13993003.00478-2015DOI Listing
January 2016

How to Monitor Early Cystic Fibrosis Lung Disease. By Multiple-Breath Washout, Chest Computed Tomography, or Both?

Am J Respir Crit Care Med 2016 Jan;193(1):7-8

2 University Children's Hospital Bern Bern, Switzerland and.

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http://dx.doi.org/10.1164/rccm.201509-1862EDDOI Listing
January 2016

Using the same cut-off for sulfur hexafluoride and nitrogen multiple-breath washout may not be appropriate.

J Appl Physiol (1985) 2015 Dec 9;119(12):1510-2. Epub 2015 Jul 9.

University Children's Hospital Bern, Bern, Switzerland; University Children's Hospital Basel, UKBB, Basel, Switzerland; and

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http://dx.doi.org/10.1152/japplphysiol.00333.2015DOI Listing
December 2015

Last Word on Viewpoint: Using the same cut-off for sulfur hexafluoride and nitrogen multiple-breath washout may not be appropriate.

J Appl Physiol (1985) 2015 Dec;119(12):1515

University Children's Hospital Bern, Bern, Switzerland; University Children's Hospital Basel, UKBB, Basel, Switzerland; and

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http://dx.doi.org/10.1152/japplphysiol.00764.2015DOI Listing
December 2015

The burden of severe asthma in childhood and adolescence: results from the paediatric U-BIOPRED cohorts.

Eur Respir J 2015 Nov 24;46(5):1322-33. Epub 2015 Sep 24.

NIHR Southampton Respiratory Biomedical Research Unit, Clinical and Experimental Sciences and Human Development and Health, Southampton, UK Faculty of Medicine, University of Southampton, Southampton, UK The David Hide Asthma and Allergy Research Centre, St Mary's Hospital, Isle of Wight, UK

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http://www.copsac.com/userfiles/2015_Flemming-Eur%20resp%20J
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http://erj.ersjournals.com/lookup/doi/10.1183/13993003.00780
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http://dx.doi.org/10.1183/13993003.00780-2015DOI Listing
November 2015

Feasibility of automated slope III and Scond analysis in children.

Pediatr Pulmonol 2015 Aug 23;50(8):805-13. Epub 2014 Jul 23.

University Children's Hospital Bern, Bern, Switzerland.

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http://dx.doi.org/10.1002/ppul.23080DOI Listing
August 2015

Alternative outcomes for the multiple breath washout in children with CF.

J Cyst Fibros 2015 Jul 8;14(4):490-6. Epub 2015 Jan 8.

Division of Respiratory Medicine, Department of Pediatrics, Hospital for Sick Children, Toronto, Canada; Physiology and Experimental Medicine, Research Institute, Hospital for Sick Children, Toronto, Canada; University of Toronto, Canada.

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http://dx.doi.org/10.1016/j.jcf.2014.12.008DOI Listing
July 2015

Validation of multiple-breath washout equipment for infants and young children.

Pediatr Pulmonol 2015 Jun 25;50(6):607-14. Epub 2014 Feb 25.

Department of Pediatrics, University Hospital of Bern, Bern, Switzerland.

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http://dx.doi.org/10.1002/ppul.23010DOI Listing
June 2015

Validation of a photoacoustic gas analyser for the measurement of functional residual capacity using multiple-breath inert gas washout.

Respiration 2014 13;87(6):462-8. Epub 2014 Feb 13.

Institute for Lung Health, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1159/000357786DOI Listing
April 2015

Arterial stiffness is increased in asthmatic children.

Eur J Pediatr 2015 Apr 25;174(4):519-23. Epub 2014 Sep 25.

Division of Pediatric Nephrology, Department of Pediatrics, Inselspital, Bern University Hospital, and University of Bern, 3010, Bern, Switzerland,

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http://dx.doi.org/10.1007/s00431-014-2423-2DOI Listing
April 2015

Double tracer gas single-breath washout: reproducibility in healthy subjects and COPD.

Eur Respir J 2014 Nov 7;44(5):1210-22. Epub 2014 Aug 7.

Klinik Schillerhöhe, Center for Respiratory Medicine and Thoracic Surgery, Robert-Bosch-Krankenhaus-GmbH, Stuttgart, Germany.

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http://dx.doi.org/10.1183/09031936.00085713DOI Listing
November 2014

Can infant lung function predict respiratory morbidity during the first year of life in preterm infants?

Eur Respir J 2014 Jun 2;43(6):1642-51. Epub 2014 Apr 2.

University Children's Hospital (UKBB), Basel, Switzerland.

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http://dx.doi.org/10.1183/09031936.00149213DOI Listing
June 2014

Ventilatory response to nitrogen multiple-breath washout in infants.

Pediatr Pulmonol 2014 Apr 12;49(4):342-7. Epub 2013 Jul 12.

Department of Paediatrics, University Hospital of Bern, Bern, Switzerland; University Children's Hospital of Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1002/ppul.22841DOI Listing
April 2014

Impact of different breathing protocols on multiple-breath washout outcomes in children.

J Cyst Fibros 2014 Mar 25;13(2):190-7. Epub 2013 Sep 25.

Division of Respiratory Medicine, Department of Pediatrics, University Children's Hospital of Bern, Switzerland; University Children's Hospital of Basel UKBB, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.jcf.2013.08.010DOI Listing
March 2014

Abnormal small airways function in children with mild asthma.

Chest 2014 Mar;145(3):492-499

University Children's Hospital Bern, Bern; University Children's Hospital Basel, Basel, Switzerland. Electronic address:

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http://dx.doi.org/10.1378/chest.13-0784DOI Listing
March 2014

Reasons for heterogeneous change in LCI in children with cystic fibrosis after antibiotic treatment.

Thorax 2014 Feb 29;69(2):183. Epub 2013 Aug 29.

Division of Respiratory Medicine, Department of Pediatrics, University Children's Hospital of Bern, , Bern, Switzerland.

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http://dx.doi.org/10.1136/thoraxjnl-2013-204283DOI Listing
February 2014

Treatment response of airway clearance assessed by single-breath washout in children with cystic fibrosis.

J Cyst Fibros 2013 Dec 19;12(6):567-74. Epub 2013 Jun 19.

Division of Respiratory Medicine, Department of Pediatrics, University Hospital of Bern, 3010 Bern, Switzerland.

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http://dx.doi.org/10.1016/j.jcf.2013.05.010DOI Listing
December 2013

Practicability of nitrogen multiple-breath washout measurements in a pediatric cystic fibrosis outpatient setting.

Pediatr Pulmonol 2013 Aug 8;48(8):739-46. Epub 2012 Aug 8.

Division of Respiratory Medicine, Department of Pediatrics, University Hospital of Bern, Bern, Switzerland.

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http://dx.doi.org/10.1002/ppul.22651DOI Listing
August 2013

Multiple-breath washout measurements can be significantly shortened in children.

Thorax 2013 Jun 31;68(6):586-7. Epub 2012 Oct 31.

Department of Paediatrics, University Children's Hospital of Bern, Bern, Switzerland.

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http://dx.doi.org/10.1136/thoraxjnl-2012-202345DOI Listing
June 2013

High rhinovirus burden in lower airways of children with cystic fibrosis.

Chest 2013 Mar;143(3):782-790

Division of Pediatric Respiratory Medicine, Department of Pediatrics, University Hospital, Bern, Switzerland; Department of Clinical Research, University of Bern, Bern, Switzerland. Electronic address:

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http://dx.doi.org/10.1378/chest.12-0954DOI Listing
March 2013

A new double-tracer gas single-breath washout to assess early cystic fibrosis lung disease.

Eur Respir J 2013 Feb 17;41(2):339-45. Epub 2012 May 17.

Division of Respiratory Medicine, Dept. of Paediatrics, University Hospital of Bern, Bern, Switzerland.

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http://dx.doi.org/10.1183/09031936.00044312DOI Listing
February 2013

A realistic validation study of a new nitrogen multiple-breath washout system.

PLoS One 2012 27;7(4):e36083. Epub 2012 Apr 27.

Division of Respiratory Medicine, Department of Paediatrics, University Children's Hospital of Bern, Bern, Switzerland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0036083PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338632PMC
September 2012

Comparison of online single-breath vs. online multiple-breath exhaled nitric oxide in school-age children.

Pediatr Res 2012 May 9;71(5):605-11. Epub 2012 Feb 9.

Department of Pediatrics, Inselspital, University of Bern, Bern, Switzerland.

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http://dx.doi.org/10.1038/pr.2012.13DOI Listing
May 2012

Long-term course of lung clearance index between infancy and school-age in cystic fibrosis subjects.

J Cyst Fibros 2011 Dec 10;10(6):487-90. Epub 2011 Aug 10.

Division of Respiratory Medicine, Department of Paediatrics, University Children's Hospital of Bern, Inselspital, 3010 Bern, Switzerland.

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http://dx.doi.org/10.1016/j.jcf.2011.07.006DOI Listing
December 2011

Tidal volume single breath washout of two tracer gases--a practical and promising lung function test.

PLoS One 2011 Mar 10;6(3):e17588. Epub 2011 Mar 10.

Division of Respiratory Medicine, Department of Paediatrics, University Children's Hospital of Bern, Bern, Switzerland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0017588PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3053358PMC
March 2011

Cysteinyl-leukotrienes in nasal lavage fluid in children with asthma.

Pediatr Allergy Immunol 2008 May;19(3):227-32

Department of Paediatric Surgery, Donauspital, Vienna, Austria.

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http://dx.doi.org/10.1111/j.1399-3038.2007.00614.xDOI Listing
May 2008

Influence of electromagnetic fields on function of automated external defibrillators.

Acad Emerg Med 2006 Jan 19;13(1):1-6. Epub 2005 Dec 19.

Department of Emergency Medicine, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria.

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http://dx.doi.org/10.1197/j.aem.2005.07.036DOI Listing
January 2006