Publications by authors named "Florian Krammer"

276 Publications

Collaboration between the Fab and Fc contribute to maximal protection against SARS-CoV-2 following NVX-CoV2373 subunit vaccine with Matrix-M™ vaccination.

Authors:
Galit Alter Matthew Gorman Nita Patel Mimi Guebre-Xabier Alex Zhu Caroline Atyeo Krista Pullen Carolin Loos Yenny Goez-Gazi Ricardo Carrion Jing-Hui Tian Dansu Yuan Kathryn Bowman Bin Zhou Sonia Maciejewski Marisa McGrath James Logue Matthew Frieman David Montefiori Sharon Schendel Erica Ollmann Saphire Douglas Lauffenburger Ann Greene Alyse Portnoff Michael Massare Larry Ellingsworth Gregory Glenn Gale Smith Colin Mann Fatima Amanat Florian Krammer

Res Sq 2021 Feb 15. Epub 2021 Feb 15.

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February 2021

Quantifying Absolute Neutralization Titers against SARS-CoV-2 by a Standardized Virus Neutralization Assay Allows for Cross-Cohort Comparisons of COVID-19 Sera.

Authors:
Kasopefoluwa Y Oguntuyo Christian S Stevens Chuan Tien Hung Satoshi Ikegame Joshua A Acklin Shreyas S Kowdle Jillian C Carmichael Hsin-Ping Chiu Kristopher D Azarm Griffin D Haas Fatima Amanat Jéromine Klingler Ian Baine Suzanne Arinsburg Juan C Bandres Mohammed N A Siddiquey Robert M Schilke Matthew D Woolard Hongbo Zhang Andrew J Duty Thomas A Kraus Thomas M Moran Domenico Tortorella Jean K Lim Andrea V Gamarnik Catarina E Hioe Susan Zolla-Pazner Stanimir S Ivanov Jeremy P Kamil Florian Krammer Benhur Lee

mBio 2021 02 16;12(1). Epub 2021 Feb 16.

Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA

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February 2021

Mutations in the Hemagglutinin Stalk Domain Do Not Permit Escape from a Protective, Stalk-Based Vaccine-Induced Immune Response in the Mouse Model.

Authors:
Ericka Kirkpatrick Roubidoux Juan Manuel Carreño Meagan McMahon Kaijun Jiang Harm van Bakel Patrick Wilson Florian Krammer

mBio 2021 Feb 16;12(1). Epub 2021 Feb 16.

Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA

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February 2021

Influenza hemagglutinin-specific IgA Fc-effector functionality is restricted to stalk epitopes.

Authors:
Alec W Freyn Julianna Han Jenna J Guthmiller Mark J Bailey Karlynn Neu Hannah L Turner Victoria C Rosado Veronika Chromikova Min Huang Shirin Strohmeier Sean T H Liu Viviana Simon Florian Krammer Andrew B Ward Peter Palese Patrick C Wilson Raffael Nachbagauer

Proc Natl Acad Sci U S A 2021 Feb;118(8)

Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029;

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February 2021

Identification and Characterization of Novel Antibody Epitopes on the N2 Neuraminidase.

Authors:
Ericka Kirkpatrick Roubidoux Meagan McMahon Juan Manuel Carreño Christina Capuano Kaijun Jiang Viviana Simon Harm van Bakel Patrick Wilson Florian Krammer

mSphere 2021 02 10;6(1). Epub 2021 Feb 10.

Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA

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February 2021

Collaboration between the Fab and Fc contribute to maximal protection against SARS-CoV-2 in nonhuman primates following NVX-CoV2373 subunit vaccine with Matrix-M™ vaccination.

Authors:
Matthew J Gorman Nita Patel Mimi Guebre-Xabier Alex Zhu Caroline Atyeo Krista M Pullen Carolin Loos Yenny Goez-Gazi Ricardo Carrion Jing-Hui Tian Dansu Yaun Kathryn Bowman Bin Zhou Sonia Maciejewski Marisa E McGrath James Logue Matthew B Frieman David Montefiori Colin Mann Sharon Schendel Fatima Amanat Florian Krammer Erica Ollmann Saphire Douglas Lauffenburger Ann M Greene Alyse D Portnoff Michael J Massare Larry Ellingsworth Gregory Glenn Gale Smith Galit Alter

bioRxiv 2021 Feb 5. Epub 2021 Feb 5.

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February 2021

Integrated immune dynamics define correlates of COVID-19 severity and antibody responses.

Authors:
Marios Koutsakos Louise C Rowntree Luca Hensen Brendon Y Chua Carolien E van de Sandt Jennifer R Habel Wuji Zhang Xiaoxiao Jia Lukasz Kedzierski Thomas M Ashhurst Givanna H Putri Felix Marsh-Wakefield Mark N Read Davis N Edwards E Bridie Clemens Chinn Yi Wong Francesca L Mordant Jennifer A Juno Fatima Amanat Jennifer Audsley Natasha E Holmes Claire L Gordon Olivia C Smibert Jason A Trubiano Carly M Hughes Mike Catton Justin T Denholm Steven Yc Tong Denise L Doolan Tom C Kotsimbos David C Jackson Florian Krammer Dale I Godfrey Amy W Chung Nicholas Jc King Sharon R Lewin Adam K Wheatley Stephen J Kent Kanta Subbarao James McMahon Irani Thevarajan Thi Ho Nguyen Allen C Cheng Katherine Kedzierska

Cell Rep Med 2021 Feb 5:100208. Epub 2021 Feb 5.

Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.

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February 2021

The E484K mutation in the SARS-CoV-2 spike protein reduces but does not abolish neutralizing activity of human convalescent and post-vaccination sera.

Authors:
Sonia Jangra Chengjin Ye Raveen Rathnasinghe Daniel Stadlbauer Florian Krammer Viviana Simon Luis Martinez-Sobrido Adolfo Garcia-Sastre Michael Schotsaert

medRxiv 2021 Jan 29. Epub 2021 Jan 29.

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January 2021

A replication competent adenovirus-vectored influenza vaccine induces durable systemic and mucosal immunity.

Authors:
Kenta Matsuda Stephen A Migueles Jinghe Huang Lyuba Bolkhovitinov Sarah Stuccio Trevor Griesman Alyssa A Pullano Byong H Kang Elise Ishida Matthew Zimmerman Neena Kashyap Kelly M Martins Daniel Stadlbauer Jessica Pederson Andy Patamawenu Nathaniel E Wright Tulley Shofner Sean Evans C Jason Liang Julián Candia Angelique Biancotto Giovanna Fantoni April Poole Jonathan Smith Jeff Alexander Marc Gurwith Florian Krammer Mark Connors

J Clin Invest 2021 Feb 2. Epub 2021 Feb 2.

HIV-Specific Immunity Section of the Laboratory of Immunoregulation, National Institutes of Allergy and Infectious Diseases, NIH, Bethesda, United States of America.

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February 2021

Pandemic Vaccines: How Are We Going to Be Better Prepared Next Time?

Authors:
Florian Krammer

Med (N Y) 2020 Dec 5;1(1):28-32. Epub 2020 Dec 5.

Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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December 2020

Longitudinal SARS-CoV-2 seroconversion and functional heterogeneity in a pediatric dialysis unit.

Authors:
Jorge J Canas Michelle C Starr Jenaya Hooks Samuel Arregui Amy C Wilson Aaron E Carroll Vijay Saxena Fatima Amanat Florian Krammer Jeffrey Fill Andrew Schade Antonio Chambers Jack Schneider Andrew L Schwaderer David S Hains

Kidney Int 2021 02;99(2):484-486

Department of Pediatrics, Indiana University, Indianapolis, Indiana, USA; Department of Microbiology and Immunology, Indiana University, Indianapolis, Indiana, USA. Electronic address:

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February 2021

The N501Y mutation in SARS-CoV-2 spike leads to morbidity in obese and aged mice and is neutralized by convalescent and post-vaccination human sera.

Authors:
Raveen Rathnasinghe Sonia Jangra Anastasija Cupic Carles Martínez-Romero Lubbertus C F Mulder Thomas Kehrer Soner Yildiz Angela Choi Ignacio Mena Jana De Vrieze Sadaf Aslam Daniel Stadlbauer David A Meekins Chester D McDowell Velmurugan Balaraman Juergen A Richt Bruno G De Geest Lisa Miorin Florian Krammer Viviana Simon Adolfo García-Sastre Michael Schotsaert

medRxiv 2021 Jan 20. Epub 2021 Jan 20.

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January 2021

A 10-Minute "Mix and Read" Antibody Assay for SARS-CoV-2.

Authors:
Juuso Rusanen Lauri Kareinen Lev Levanov Sointu Mero Sari H Pakkanen Anu Kantele Fatima Amanat Florian Krammer Klaus Hedman Olli Vapalahti Jussi Hepojoki

Viruses 2021 Jan 20;13(2). Epub 2021 Jan 20.

Department of Virology, Medicum, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland.

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January 2021

SARS-CoV-2 vaccination for patients with inflammatory bowel diseases: recommendations from an international consensus meeting.

Authors:
Corey A Siegel Gil Y Melmed Dermot Pb McGovern Victoria Rai Florian Krammer David T Rubin Maria T Abreu Marla C Dubinsky

Gut 2021 Jan 20. Epub 2021 Jan 20.

Department of Pediatrics, Susan and Leonard Feinstein IBD Center, Icahn School of Medicine, Mount Sinai, New York, New York, USA.

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January 2021

Differential T cell reactivity to seasonal coronaviruses and SARS-CoV-2 in community and health care workers.

Authors:
Ricardo da Silva Antunes Suresh Pallikkuth Erin Williams Esther Dawen Yu Jose Mateus Lorenzo Quiambao Eric Wang Stephen A Rawlings Daniel Stadlbauer Kaijun Jiang Fatima Amanat David Arnold David Andrews Irma Fuego Jennifer M Dan Alba Grifoni Daniela Weiskopf Florian Krammer Shane Crotty Michael E Hoffer Savita G Pahwa Alessandro Sette

medRxiv 2021 Jan 15. Epub 2021 Jan 15.

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January 2021

SARS-CoV-2 Infection Severity Is Linked to Superior Humoral Immunity against the Spike.

Authors:
Jenna J Guthmiller Olivia Stovicek Jiaolong Wang Siriruk Changrob Lei Li Peter Halfmann Nai-Ying Zheng Henry Utset Christopher T Stamper Haley L Dugan William D Miller Min Huang Ya-Nan Dai Christopher A Nelson Paige D Hall Maud Jansen Kumaran Shanmugarajah Jessica S Donington Florian Krammer Daved H Fremont Andrzej Joachimiak Yoshihiro Kawaoka Vera Tesic Maria Lucia Madariaga Patrick C Wilson

mBio 2021 01 19;12(1). Epub 2021 Jan 19.

Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, Illinois, USA

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January 2021

Sterilizing Immunity against SARS-CoV-2 Infection in Mice by a Single-Shot and Lipid Amphiphile Imidazoquinoline TLR7/8 Agonist-Adjuvanted Recombinant Spike Protein Vaccine.

Authors:
Sonia Jangra Jana De Vrieze Angela Choi Raveen Rathnasinghe Gabriel Laghlali Annemiek Uvyn Simon Van Herck Lutz Nuhn Kim Deswarte Zifu Zhong Niek Sanders Stefan Lienenklaus Sunil David Shirin Strohmeier Fatima Amanat Florian Krammer Hamida Hammad Bart N Lambrecht Lynda Coughlan Adolfo García-Sastre Bruno de Geest Michael Schotsaert

Angew Chem Int Ed Engl 2021 Jan 19. Epub 2021 Jan 19.

Mount Sinai School of Medicine: Icahn School of Medicine at Mount Sinai, Microbiology, UNITED STATES.

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January 2021

Intranasal ChAdOx1 nCoV-19/AZD1222 vaccination reduces shedding of SARS-CoV-2 D614G in rhesus macaques.

Authors:
Neeltje van Doremalen Jyothi Purushotham Jonathan Schulz Myndi Holbrook Trenton Bushmaker Aaron Carmody Julia Port Kwe Claude Yinda Atsushi Okumura Greg Saturday Fatima Amanat Florian Krammer Patrick Hanley Brian Smith Jamie Lovaglio Sarah Anzick Kent Barbian Craig Martens Sarah C Gilbert Teresa Lambe Vincent Munster

bioRxiv 2021 Jan 11. Epub 2021 Jan 11.

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January 2021

Immunological memory to SARS-CoV-2 assessed for up to eight months after infection.

Authors:
Jennifer M Dan Jose Mateus Yu Kato Kathryn M Hastie Esther Dawen Yu Caterina E Faliti Alba Grifoni Sydney I Ramirez Sonya Haupt April Frazier Catherine Nakao Vamseedhar Rayaprolu Stephen A Rawlings Bjoern Peters Florian Krammer Viviana Simon Erica Ollmann Saphire Davey M Smith Daniela Weiskopf Alessandro Sette Shane Crotty

bioRxiv 2020 Dec 18. Epub 2020 Dec 18.

Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.

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December 2020

Chimeric Hemagglutinin-Based Live-Attenuated Vaccines Confer Durable Protective Immunity against Influenza A Viruses in a Preclinical Ferret Model.

Authors:
Wen-Chun Liu Raffael Nachbagauer Daniel Stadlbauer Shirin Strohmeier Alicia Solórzano Francesco Berlanda-Scorza Bruce L Innis Adolfo García-Sastre Peter Palese Florian Krammer Randy A Albrecht

Vaccines (Basel) 2021 Jan 11;9(1). Epub 2021 Jan 11.

Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

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January 2021

Heterologous viral protein interactions within licensed seasonal influenza virus vaccines.

Authors:
Marina Koroleva Frances Batarse Savannah Moritzky Carole Henry Francisco Chaves Patrick Wilson Florian Krammer Katherine Richards Andrea J Sant

NPJ Vaccines 2020 Jan 10;5(1). Epub 2020 Jan 10.

David H. Smith Center for Vaccine Biology and Immunology, Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY, USA.

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January 2020

Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection.

Authors:
Jennifer M Dan Jose Mateus Yu Kato Kathryn M Hastie Esther Dawen Yu Caterina E Faliti Alba Grifoni Sydney I Ramirez Sonya Haupt April Frazier Catherine Nakao Vamseedhar Rayaprolu Stephen A Rawlings Bjoern Peters Florian Krammer Viviana Simon Erica Ollmann Saphire Davey M Smith Daniela Weiskopf Alessandro Sette Shane Crotty

Science 2021 02 6;371(6529). Epub 2021 Jan 6.

Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA.

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February 2021

A Newcastle Disease Virus (NDV) Expressing a Membrane-Anchored Spike as a Cost-Effective Inactivated SARS-CoV-2 Vaccine.

Authors:
Weina Sun Stephen McCroskery Wen-Chun Liu Sarah R Leist Yonghong Liu Randy A Albrecht Stefan Slamanig Justine Oliva Fatima Amanat Alexandra Schäfer Kenneth H Dinnon Bruce L Innis Adolfo García-Sastre Florian Krammer Ralph S Baric Peter Palese

Vaccines (Basel) 2020 Dec 17;8(4). Epub 2020 Dec 17.

Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

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December 2020

H1 Hemagglutinin Priming Provides Long-Lasting Heterosubtypic Immunity against H5N1 Challenge in the Mouse Model.

Authors:
Juan Manuel Carreño Shirin Strohmeier Ericka Kirkpatrick Roubidoux Rong Hai Peter Palese Florian Krammer

mBio 2020 12 15;11(6). Epub 2020 Dec 15.

Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA

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December 2020

Preexisting immunity shapes distinct antibody landscapes after influenza virus infection and vaccination in humans.

Authors:
Haley L Dugan Jenna J Guthmiller Philip Arevalo Min Huang Yao-Qing Chen Karlynn E Neu Carole Henry Nai-Ying Zheng Linda Yu-Ling Lan Micah E Tepora Olivia Stovicek Dalia Bitar Anna-Karin E Palm Christopher T Stamper Siriruk Changrob Henry A Utset Lynda Coughlan Florian Krammer Sarah Cobey Patrick C Wilson

Sci Transl Med 2020 12;12(573)

Committee on Immunology, University of Chicago, Chicago, IL 60637, USA.

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December 2020

SARS-CoV-2 mRNA Vaccines Foster Potent Antigen-Specific Germinal Center Responses Associated with Neutralizing Antibody Generation.

Authors:
Katlyn Lederer Diana Castaño Daniela Gómez Atria Thomas H Oguin Sidney Wang Tomaz B Manzoni Hiromi Muramatsu Michael J Hogan Fatima Amanat Patrick Cherubin Kendall A Lundgreen Ying K Tam Steven H Y Fan Laurence C Eisenlohr Ivan Maillard Drew Weissman Paul Bates Florian Krammer Gregory D Sempowski Norbert Pardi Michela Locci

Immunity 2020 12 21;53(6):1281-1295.e5. Epub 2020 Nov 21.

Department of Microbiology, Center for Research on Coronavirus and Other Emerging Pathogens, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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December 2020

Pre-existing Hemagglutinin Stalk Antibodies Correlate with Protection of Lower Respiratory Symptoms in Flu-Infected Transplant Patients.

Authors:
Teresa Aydillo Alba Escalera Shirin Strohmeier Sadaf Aslam Javier Sanchez-Cespedes Juan Ayllon Cristina Roca-Oporto Pilar Perez-Romero Miguel Montejo Joan Gavalda Patricia Munoz Francisco Lopez-Medrano Jordi Carratala Florian Krammer Adolfo García-Sastre Elisa Cordero

Cell Rep Med 2020 Nov 3;1(8):100130. Epub 2020 Nov 3.

Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville, Virgen del Rocío University Hospital/CSIC/University of Seville, Seville, Spain.

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November 2020

Female-biased effects of aging on a chimeric hemagglutinin stalk-based universal influenza virus vaccine in mice.

Authors:
Santosh Dhakal Sharvari Deshpande Meagan McMahon Shirin Strohmeier Florian Krammer Sabra L Klein

Vaccine 2020 Dec 5. Epub 2020 Dec 5.

W. Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA; Department of Biochemistry and Molecular Biology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA. Electronic address:

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December 2020

A chimeric hemagglutinin-based universal influenza virus vaccine approach induces broad and long-lasting immunity in a randomized, placebo-controlled phase I trial.

Authors:
Raffael Nachbagauer Jodi Feser Abdollah Naficy David I Bernstein Jeffrey Guptill Emmanuel B Walter Franceso Berlanda-Scorza Daniel Stadlbauer Patrick C Wilson Teresa Aydillo Mohammad Amin Behzadi Disha Bhavsar Carly Bliss Christina Capuano Juan Manuel Carreño Veronika Chromikova Carine Claeys Lynda Coughlan Alec W Freyn Christopher Gast Andres Javier Kaijun Jiang Chiara Mariottini Meagan McMahon Monica McNeal Alicia Solórzano Shirin Strohmeier Weina Sun Marie Van der Wielen Bruce L Innis Adolfo García-Sastre Peter Palese Florian Krammer

Nat Med 2021 01 7;27(1):106-114. Epub 2020 Dec 7.

Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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January 2021

Real-Time Investigation of a Large Nosocomial Influenza A Outbreak Informed by Genomic Epidemiology.

Authors:
Waleed Javaid Jordan Ehni Ana S Gonzalez-Reiche Juan Manuel Carreño Elena Hirsch Jessica Tan Zenab Khan Divya Kriti Thanh Ly Bethany Kranitzky Barbara Barnett Freddy Cera Lenny Prespa Marie Moss Randy A Albrecht Ala Mustafa Ilka Herbison Matthew M Hernandez Theodore R Pak Hala Alshammary Robert Sebra Melissa Smith Florian Krammer Melissa R Gitman Emilia Mia Sordillo Viviana Simon Harm van Bakel

Clin Infect Dis 2020 Nov 30. Epub 2020 Nov 30.

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY.

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November 2020