Publications by authors named "Florian Kern"

86Publications

Governing the second deep transition towards a circular economy: How rules emerge, align and diffuse.

Environ Innov Soc Transit 2020 Dec 16;37:171-186. Epub 2020 Sep 16.

Institute for Ecological Economy Research, Potsdamer Str. 105, 10785 Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.eist.2020.08.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7493796PMC
December 2020

CD28 CD4 T-cell expansions in autoimmune disease suggest a link with cytomegalovirus infection.

F1000Res 2019 25;8. Epub 2019 Mar 25.

Department of Clinical and Experimental medicine, Brighton and Sussex Medical School, Brighton, Sussex, BN1 9PX, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12688/f1000research.17119.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436193PMC
May 2020

Baseline Cytokine Profiles of Tuberculin-Specific CD4 T Cells in Non-Muscle-Invasive Bladder Cancer May Predict Outcomes of BCG Immunotherapy.

Cancer Immunol Res 2018 10 17;6(10):1212-1219. Epub 2018 Aug 17.

Department of Clinical and Experimental Medicine, Brighton and Sussex Medical School, Brighton, United Kingdom.

View Article

Download full-text PDF

Source
http://cancerimmunolres.aacrjournals.org/lookup/doi/10.1158/
Publisher Site
http://dx.doi.org/10.1158/2326-6066.CIR-18-0046DOI Listing
October 2018

Interleukin-7 Unveils Pathogen-Specific T Cells by Enhancing Antigen-Recall Responses.

J Infect Dis 2018 05;217(12):1997-2007

Brighton and Sussex Medical School, The University of Sussex, Falmer, East Sussex, United Kingdom.

View Article

Download full-text PDF

Source
https://academic.oup.com/jid/article/217/12/1997/4913790
Publisher Site
http://dx.doi.org/10.1093/infdis/jiy096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5972594PMC
May 2018

FABP1 and Hepar expression levels in Barrett's esophagus and associated neoplasia in an Asian population.

Dig Liver Dis 2017 Oct 27;49(10):1104-1109. Epub 2017 Jul 27.

Department of Pathology, National University Health System, Singapore. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.dld.2017.06.014DOI Listing
October 2017

Endoscopic modalities for the diagnosis of Barrett's oesophagus.

United European Gastroenterol J 2016 Dec 15;4(6):733-740. Epub 2015 Dec 15.

National University Hospital, Singapore.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2050640615619281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386224PMC
December 2016

Cytomegalovirus as a Driver of Excess Cardiovascular Mortality in Rheumatoid Arthritis: A Red Herring or a Smoking Gun?

Circ Res 2017 01;120(2):274-277

From the Division of Clinical and Experimental Medicine, Brighton and Sussex Medical School, United Kingdom (A.P., I.B., K.A.D., F.K.); and Department of Immunology, Maimonides Institute for Biomedical Research (IMIBIC), Reina Sofía University Hospital, University of Cordoba, Spain (A.P.).

View Article

Download full-text PDF

Source
https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.116.30998
Publisher Site
http://dx.doi.org/10.1161/CIRCRESAHA.116.309982DOI Listing
January 2017

Circulating Plasma microRNAs can differentiate Human Sepsis and Systemic Inflammatory Response Syndrome (SIRS).

Sci Rep 2016 06 20;6:28006. Epub 2016 Jun 20.

Brighton and Sussex Medical School, Falmer, East Sussex, BN1 9PS, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/srep28006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4913253PMC
June 2016

A new perspective of the structural complexity of HCMV-specific T-cell responses.

Mech Ageing Dev 2016 09 5;158:14-22. Epub 2016 Mar 5.

Division of Medicine, Brighton and Sussex Medical School, Brighton BN1 9PX, United Kingdom. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mad.2016.03.002DOI Listing
September 2016

Cytotoxic polyfunctionality maturation of cytomegalovirus-pp65-specific CD4 + and CD8 + T-cell responses in older adults positively correlates with response size.

Sci Rep 2016 Jan 18;6:19227. Epub 2016 Jan 18.

Division of Geriatric Medicine and Gerontology, Biology of Healthy Aging Program, Johns Hopkins University School of Medicine, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/srep19227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726016PMC
January 2016

Cloning and variation of ground state intestinal stem cells.

Nature 2015 Jun 3;522(7555):173-8. Epub 2015 Jun 3.

1] The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut 06032, USA [2] Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, Connecticut 06032, USA [3] Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts 02118, USA [4] Department of Medicine, National University of Singapore, 119228 Singapore [5] Multiclonal Therapeutics, Inc., Farmington, Connecticut 06032, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature14484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853906PMC
June 2015

Gender differences and age-specific associations between body mass index and other cardiovascular risk factors in CMV infected and uninfected people.

Immunol Lett 2014 Nov 22;162(1 Pt B):316-22. Epub 2014 Sep 22.

Division of Primary Care and Public Health, Brighton and Sussex Medical School, Brighton, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.imlet.2014.09.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4717515PMC
November 2014

WITHDRAWN: Gender differences and age-specific associations between Body Mass Index and other cardiovascular risk factors in CMV infected and uninfected people.

Immunol Lett 2014 Sep 22. Epub 2014 Sep 22.

Division of Medicine, Brighton and Sussex Medical School, Brighton, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.imlet.2014.09.010DOI Listing
September 2014

Cell-mediated immunity to human CMV infection: a brief overview.

F1000Prime Rep 2014 6;6:28. Epub 2014 May 6.

Pathogen Host Interaction Group (PHI), Immunology, Division of Medicine, Brighton and Sussex Medical School Biology Road, Brighton, BN1 9PS UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12703/P6-28DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018181PMC
June 2014

Characterisation of CD154+ T cells following ex vivo allergen stimulation illustrates distinct T cell responses to seasonal and perennial allergens in allergic and non-allergic individuals.

BMC Immunol 2013 Nov 5;14:49. Epub 2013 Nov 5.

Brighton and Sussex Medical School, division of clinical medicine, pathogen-host-interactions group, University of Sussex, Brighton BN1 9PS, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1471-2172-14-49DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4228241PMC
November 2013

Detection of tuberculosis in HIV-infected and -uninfected African adults using whole blood RNA expression signatures: a case-control study.

PLoS Med 2013 Oct 22;10(10):e1001538. Epub 2013 Oct 22.

Section of Paediatrics and Wellcome Trust Centre for Clinical Tropical Medicine, Division of Infectious Diseases, Department of Medicine, Imperial College London, London, United Kingdom ; Department of Genomics of Common Disease, School of Public Health, Imperial College London, London, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pmed.1001538DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3805485PMC
October 2013

Skin tumorigenesis stimulated by Raf inhibitors relies upon Raf functions that are dependent and independent of ERK.

Cancer Res 2013 Dec 15;73(23):6926-37. Epub 2013 Oct 15.

Authors' Affiliation: Department of Microbiology, Immunobiology and Genetics, University of Vienna, Max F. Perutz Laboratories, Vienna, Austria.

View Article

Download full-text PDF

Source
http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
Publisher Site
http://dx.doi.org/10.1158/0008-5472.CAN-13-0748DOI Listing
December 2013

Characterisation of CD154+ T cells following ex vivo birch allergen stimulation defines a close relationship between T cell subsets in healthy volunteers.

BMC Immunol 2013 Mar 22;14:14. Epub 2013 Mar 22.

Brighton and Sussex Medical School, Division of Clinical Medicine, Pathogen-Host-Interactions Group, University of Sussex, Brighton, BN1 9PS, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1471-2172-14-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614533PMC
March 2013

The phenotypic distribution and functional profile of tuberculin-specific CD4 T-cells characterizes different stages of TB infection.

Cytometry B Clin Cytom 2012 Nov 7;82(6):360-8. Epub 2012 Sep 7.

Institut für Medizinische Immunologie der Charité, Campus Mitte, Charité - Universitätsmedizin Berlin, Campus Mitte, Charitéplatz 1, 10117 Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cyto.b.21041DOI Listing
November 2012

Simultaneous monitoring of cytomegalovirus-specific antibody and T-cell levels in seropositive heart transplant recipients.

J Clin Immunol 2012 Aug 29;32(4):809-19. Epub 2012 Feb 29.

Transplant Immunology Group, Clinical Immunology Department, Gregorio Marañón Hospital, Dr Esquerdo 46, 28007, Madrid, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10875-012-9670-7DOI Listing
August 2012

Amyloid-specific T-cells differentiate Alzheimer's disease from Lewy body dementia.

Neurobiol Aging 2012 Nov 11;33(11):2599-611. Epub 2012 Feb 11.

Cell Signalling Unit, Department of Medicine and Aging Sciences, University G. d'Annunzio of Chieti-Pescara, Chieti, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neurobiolaging.2012.01.004DOI Listing
November 2012

The Nogo receptor 2 is a novel substrate of Fbs1.

Biochem Biophys Res Commun 2012 Jan 20;417(3):977-81. Epub 2011 Dec 20.

Neurobiochemistry - Biocenter, Innsbruck Medical University, Austria.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2011.12.050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3269754PMC
January 2012

Comparative study of the influence of proteasome inhibitor MG132 and ganciclovir on the cytomegalovirus-specific CD8(+) T-cell immune response.

Viral Immunol 2011 Dec 23;24(6):455-61. Epub 2011 Nov 23.

Institut für Medizinische Immunologie der Charité, Abteilung Klinische Immunologie, Humboldt-Universität zu Berlin (Charité), Campus Charité Mitte, Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/vim.2011.0038DOI Listing
December 2011

Polyfunctional T cells accumulate in large human cytomegalovirus-specific T cell responses.

J Virol 2012 Jan 9;86(2):1001-9. Epub 2011 Nov 9.

Pathogen Host Interaction Group, Division of Medicine, Brighton and Sussex Medical School, Brighton, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.00873-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3255847PMC
January 2012

Nogo receptor is involved in the adhesion of dendritic cells to myelin.

J Neuroinflammation 2011 Sep 9;8:113. Epub 2011 Sep 9.

Clinical Department of Neurology, Innsbruck Medical University, Innsbruck, Austria.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1742-2094-8-113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3177896PMC
September 2011

Tuberculin-specific T cells are reduced in active pulmonary tuberculosis compared to LTBI or status post BCG vaccination.

J Infect Dis 2011 Feb 24;203(3):378-82. Epub 2010 Dec 24.

Institut für Medizinische Immunologie, Charité - Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/infdis/jiq065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3071115PMC
February 2011

Secondary heterologous dengue infection risk: Disequilibrium between immune regulation and inflammation?

Cell Immunol 2010 10;262(2):134-40. Epub 2010 Feb 10.

Cellular Immunology Lab, Virology Department, PAHO/WHO Collaborating Center for the Study of Dengue and its Vector, Institute of Tropical Medicine, Pedro Kouri Autopista Novia del Mediodia, La Lisa, Ciudad Habana, Cuba.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cellimm.2010.02.005DOI Listing
May 2010

Raf-1 addiction in Ras-induced skin carcinogenesis.

Cancer Cell 2009 Aug;16(2):149-60

Max F. Perutz Laboratories, Department of Microbiology and Immunobiology, University of Vienna, Vienna, Austria.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccr.2009.06.008DOI Listing
August 2009

High levels of CMV-IE-1-specific memory T cells are associated with less alloimmunity and improved renal allograft function.

Transpl Immunol 2009 Mar 24;20(4):238-42. Epub 2008 Nov 24.

Department of Nephrology and Intensive Care, Charité Campus Virchow, Augustenburger Platz 1, 13353 Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.trim.2008.11.002DOI Listing
March 2009

HIV-2 induces NF-kappaB activation and cyclooxygenase-2 expression in human astroglial cells.

Virology 2008 Oct 27;380(1):144-51. Epub 2008 Aug 27.

Centro de Biología Molecular, Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid, Cantoblanco, Madrid, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.virol.2008.07.008DOI Listing
October 2008

How flow cytometry is changing the study of TB immunology and clinical diagnosis.

Cytometry A 2008 Nov;73(11):1100-6

Division of Medicine, Brighton and Sussex Medical School, University of Sussex Campus, Brighton BN19PS, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cyto.a.20614DOI Listing
November 2008

The role of flow cytometry in the interferon-gamma-based diagnosis of active tuberculosis and its coinfection with HIV-1--A technically oriented review.

Cytometry B Clin Cytom 2008 ;74 Suppl 1:S141-51

Department of Immunology, Royal Free and University College Medical School, London, United Kingdom.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/cyto.b.20381
Publisher Site
http://dx.doi.org/10.1002/cyto.b.20381DOI Listing
May 2008

CMV-specific central memory T cells reside in bone marrow.

Eur J Immunol 2007 Nov;37(11):3063-8

Department of Hematology, Oncology, Charité, Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/eji.200636930DOI Listing
November 2007

Measurement of antigen specific immune responses: 2006 update.

Cytometry B Clin Cytom 2007 Mar;72(2):77-85

Viral Immunology, Advanced Biotechnology Center, Largo Benzi 10, 16132 Genoa, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cyto.b.20186DOI Listing
March 2007

Sorting and pooling strategy: a novel tool to map a virus proteome for CD8 T-cell epitopes.

Biopolymers 2007 ;88(1):64-75

Institut für Medizinische Immunulogie, Charite - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bip.20637DOI Listing
March 2007

Specific central memory T cells in the bone marrow of patients immunized against tyrosinase peptides.

J Immunother 2006 Mar-Apr;29(2):201-7

Department of Hematology, Oncology, and Transfusion Medicine, Charité, Campus Benjamin Franklin, Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/01.cji.0000180903.73965.72DOI Listing
May 2006

Measuring antigen-specific immune responses -- What is different and what is better?

Discov Med 2005 Oct;5(29):478-82

Institute for Medical Immunology, Charité - Universitätsmedizin Berlin, Campus Mitte, 10098 Berlin, Germany.

View Article

Download full-text PDF

Source
October 2005

Measuring Ag-specific immune responses: understanding immunopathogenesis and improving diagnostics in infectious disease, autoimmunity and cancer.

Trends Immunol 2005 Sep;26(9):477-84

Institut für Medizinische Immunologie, Charité-Universitätsmedizin Berlin, Campus Mitte, 10098 Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.it.2005.07.005DOI Listing
September 2005

Selection of CMV-specific CD8+ and CD4+ T cells by mini-EBV-transformed B cell lines.

Eur J Immunol 2005 Jul;35(7):2110-21

Department of Gene Vectors, GSF - National Research Center for Environment and Health, Munich, Germany.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/eji.200425936
Publisher Site
http://dx.doi.org/10.1002/eji.200425936DOI Listing
July 2005

HLA type-independent generation of antigen-specific T cells for adoptive immunotherapy.

Eur J Immunol 2005 Jul;35(7):2250-8

Department of Nephrology and Internal Intensive Care, Universitätsmedizin Berlin, Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/eji.200526230DOI Listing
July 2005

Use of peptides and peptide libraries as T-cell stimulants in flow cytometric studies.

Methods Cell Biol 2004 ;75:453-79

Institute for Medical Immunology, Charite, Universitätsmedizin Berlin, Campus Charité Mitte, Berlin 10117, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0091-679x(04)75018-9DOI Listing
March 2005

Cross-sectional and longitudinal analysis of myelin-reactive T cells in patients with multiple sclerosis.

J Neurol 2004 Sep;251(9):1111-20

Institute of Neuroimmunology, Neuroscience Research Center, Charité, 10098, Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00415-004-0493-1DOI Listing
September 2004

Confirmation of Mycobacterium tuberculosis infection by flow cytometry after ex vivo incubation of peripheral blood T cells with an ESAT-6-derived peptide pool.

Cytometry B Clin Cytom 2004 Jul;60(1):47-53

Institut für Medizinische Immunologie der Charité, Humboldt-Universität zu Berlin (Charité), Campus Charité Mitte, Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cyto.b.20007DOI Listing
July 2004

Analysis of antigen-specific T-cell responses with synthetic peptides--what kind of peptide for which purpose?

Hum Immunol 2004 May;65(5):523-36

Abteilung Klinische Immunologie, Institut für Medizinische Immunologie der Charité, Humboldt-Universität zu Berlin (Charité), Campus Charité Mitte, Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.humimm.2004.02.017DOI Listing
May 2004

Random screening of proteins for HLA-A*0201-binding nine-amino acid peptides is not sufficient for identifying CD8 T cell epitopes recognized in the context of HLA-A*0201.

J Immunol 2004 Jun;172(11):6783-9

Institut für Medizinische Immunologie der Charité, Humboldt-Universität zu Berlin (Charité), Campus Charité Mitte, Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.172.11.6783DOI Listing
June 2004

Detection of antigen-specific T cells by cytokine flow cytometry: the use of whole blood may underestimate frequencies.

Eur J Immunol 2003 Dec;33(12):3484-92

Institut für Medizinische Immunologie, Medizinische Fakultät der Humboldt-Universität zu Berlin, Charité, Berlin, Germany.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/eji.200324223
Publisher Site
http://dx.doi.org/10.1002/eji.200324223DOI Listing
December 2003

Mapping T cell epitopes by flow cytometry.

Methods 2003 Mar;29(3):270-81

Department of Medical Immunology, Charité, Humboldt Universität zu Berlin, Schumannstrasse 21, 10117 Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s1046-2023(02)00349-3DOI Listing
March 2003

Comparison of proliferation and rapid cytokine induction assays for flow cytometric T-cell epitope mapping.

Cytometry A 2003 Mar;52(1):36-45

Institute for Medical Immunology, Universitätsklinikum Charité der Humboldt Universität zu Berlin, Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cyto.a.10023DOI Listing
March 2003

Evaluation of the frequency of virus-specific CD8+ T cells by cytokine flow cytometry.

Methods Mol Biol 2003 ;215:59-69

Institute of Medical Immunology, Charité, Humboldt-University, Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1385/1-59259-345-3:59DOI Listing
June 2003