Florence Leroux

Florence Leroux

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Florence Leroux

Florence Leroux

Publications by authors named "Florence Leroux"

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Identification of ebselen as a potent inhibitor of insulin degrading enzyme by a drug repurposing screening.

Eur J Med Chem 2019 Oct 24;179:557-566. Epub 2019 Jun 24.

Univ. Lille, Inserm, Institut Pasteur de Lille, U1177, Drugs and Molecules for Living Systems, F-59000, Lille, France; European Genomic Institute for Diabetes, EGID, University of Lille, F-59000, France; Institut Universitaire de France, F- 75231, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2019.06.057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718346PMC
October 2019

Inhibition of aggrecanases as a therapeutic strategy in osteoarthritis.

Future Med Chem 2014 ;6(12):1399-412

INSERM U761 Biostructures & Drug Discovery unit University Lille Nord de France, Institut Pasteur de Lille, rue Laguesse, Lille, F-59000, France.

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http://dx.doi.org/10.4155/fmc.14.84DOI Listing
August 2015

Structure-activity relationships of imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, dual binders of human insulin-degrading enzyme.

Eur J Med Chem 2015 Jan 4;90:547-67. Epub 2014 Dec 4.

INSERM U761 Biostructures and Drug Discovery, Lille, France; Lille F-59000, France; Institut Pasteur de Lille, IFR 142, Lille F-59000, France; PRIM, Lille F-59000, France; CDithem Platform/IGM, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2014.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4325277PMC
January 2015

Identification of Small Inhibitory Molecules Targeting the Bfl-1 Anti-Apoptotic Protein That Alleviates Resistance to ABT-737.

J Biomol Screen 2014 Aug 8;19(7):1035-46. Epub 2014 May 8.

CDithem. Faculté de Pharmacie, Lille, France; www.CDithem.com INSERM U761, Biostructures and Drug Discovery, Université de Lille, Institut Pasteur de Lille, IFR 142, PRIM, Lille, France

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http://dx.doi.org/10.1177/1087057114534070DOI Listing
August 2014

Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-β hydrolysis.

Eur J Med Chem 2014 May 4;79:184-93. Epub 2014 Apr 4.

INSERM U761 Biostructures and Drug Discovery, Lille, France; Univ Lille Nord de France, Lille F-59000, France; Institut Pasteur de Lille, IFR 142, Lille F-59000, France; PRIM, Lille F-59000, France; CDithem Platform/IGM, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2014.04.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128174PMC
May 2014

Aggrecanase-2 inhibitors based on the acylthiosemicarbazide zinc-binding group.

Eur J Med Chem 2013 Nov 30;69:244-61. Epub 2013 Aug 30.

INSERM U761, Biostructures and Drug Discovery, France; Faculté de Pharmacie, Univ Lille Nord de France, 3 rue du Pr Laguesse, Lille F-59006, France; Institut Pasteur de Lille, IFR 142, Lille F-59021, France; PRIM, Lille F-59006, France.

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http://dx.doi.org/10.1016/j.ejmech.2013.08.027DOI Listing
November 2013

Structure-activity relationships and blood distribution of antiplasmodial aminopeptidase-1 inhibitors.

J Med Chem 2012 Dec 5;55(24):10909-17. Epub 2012 Dec 5.

INSERM U761, Biostructures and Drug Discovery and Faculté de Pharmacie, Université Lille Nord de France, 3 rue du Pr Laguesse, Lille F-59000, France.

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http://dx.doi.org/10.1021/jm301506hDOI Listing
December 2012

Drug-to-genome-to-drug, step 2: reversing selectivity in a series of antiplasmodial compounds.

J Med Chem 2012 Feb 24;55(3):1274-86. Epub 2012 Jan 24.

INSERM U761 Biostructures and Drug Discovery, Lille F-59006, France.

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http://dx.doi.org/10.1021/jm201422eDOI Listing
February 2012

Drug to genome to drug: discovery of new antiplasmodial compounds.

J Med Chem 2011 May 19;54(9):3222-40. Epub 2011 Apr 19.

INSERM U761 Biostructures and Drug Discovery, Faculté de Pharmacie, Université Lille Nord de France, Institut Pasteur de Lille, and Pôle de Recherche Interdisciplinaire pour le Médicament , Lille F-59000, France.

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http://dx.doi.org/10.1021/jm1014617DOI Listing
May 2011

New non-hydroxamic ADAMTS-5 inhibitors based on the 1,2,4-triazole-3-thiol scaffold.

Bioorg Med Chem Lett 2010 Nov 27;20(21):6213-6. Epub 2010 Aug 27.

INSERM U761 Biostructures and Drug Discovery, Univ. Lille Nord de France.

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http://dx.doi.org/10.1016/j.bmcl.2010.08.108DOI Listing
November 2010

Synthesis of a 200-member library of squaric acid N-hydroxylamide amides.

Bioorg Med Chem Lett 2008 Sep 14;18(18):4968-71. Epub 2008 Aug 14.

INSERM U761, Biostructures and Drug Discovery, 3 rue du Professeur Laguesse, Nord, Lille F-59006, France.

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http://dx.doi.org/10.1016/j.bmcl.2008.08.025DOI Listing
September 2008