Florence Demenais

Florence Demenais

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Florence Demenais

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Integration of the human exposome with the human genome to advance medicine.

Biochimie 2018 Sep 28;152:155-158. Epub 2018 Jun 28.

INSERM UMR_S1138, Sorbonne Universités, Université Pierre & Marie Curie, Université Paris Descartes, Sorbonne Paris Cité, Paris, France; Imperial College London, Section of Biomolecular Medicine, Division of Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Sir Alexander Fleming Building, London, United Kingdom; McGill University and Genome Quebec Innovation Centre, Montréal, Canada.

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http://dx.doi.org/10.1016/j.biochi.2018.06.023DOI Listing
September 2018

A novel role for ciliary function in atopy: ADGRV1 and DNAH5 interactions.

J Allergy Clin Immunol 2018 05 18;141(5):1659-1667.e11. Epub 2017 Sep 18.

Genetic Variation and Human Diseases Unit, INSERM, Université Paris Diderot, Université Sorbonne Paris Cité, Paris, France.

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http://dx.doi.org/10.1016/j.jaci.2017.06.050DOI Listing
May 2018

Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.

Authors:
Florence Demenais Patricia Margaritte-Jeannin Kathleen C Barnes William O C Cookson Janine Altmüller Wei Ang R Graham Barr Terri H Beaty Allan B Becker John Beilby Hans Bisgaard Unnur Steina Bjornsdottir Eugene Bleecker Klaus Bønnelykke Dorret I Boomsma Emmanuelle Bouzigon Christopher E Brightling Myriam Brossard Guy G Brusselle Esteban Burchard Kristin M Burkart Andrew Bush Moira Chan-Yeung Kian Fan Chung Alexessander Couto Alves John A Curtin Adnan Custovic Denise Daley Johan C de Jongste Blanca E Del-Rio-Navarro Kathleen M Donohue Liesbeth Duijts Celeste Eng Johan G Eriksson Martin Farrall Yuliya Fedorova Bjarke Feenstra Manuel A Ferreira Maxim B Freidin Zofia Gajdos Jim Gauderman Ulrike Gehring Frank Geller Jon Genuneit Sina A Gharib Frank Gilliland Raquel Granell Penelope E Graves Daniel F Gudbjartsson Tari Haahtela Susan R Heckbert Dick Heederik Joachim Heinrich Markku Heliövaara John Henderson Blanca E Himes Hiroshi Hirose Joel N Hirschhorn Albert Hofman Patrick Holt Jouke Hottenga Thomas J Hudson Jennie Hui Medea Imboden Vladimir Ivanov Vincent W V Jaddoe Alan James Christer Janson Marjo-Riitta Jarvelin Deborah Jarvis Graham Jones Ingileif Jonsdottir Pekka Jousilahti Michael Kabesch Mika Kähönen David B Kantor Alexandra S Karunas Elza Khusnutdinova Gerard H Koppelman Anita L Kozyrskyj Eskil Kreiner Michiaki Kubo Rajesh Kumar Ashish Kumar Mikko Kuokkanen Lies Lahousse Tarja Laitinen Catherine Laprise Mark Lathrop Susanne Lau Young-Ae Lee Terho Lehtimäki Sébastien Letort Albert M Levin Guo Li Liming Liang Laura R Loehr Stephanie J London Daan W Loth Ani Manichaikul Ingo Marenholz Fernando J Martinez Melanie C Matheson Rasika A Mathias Kenji Matsumoto Hamdi Mbarek Wendy L McArdle Mads Melbye Erik Melén Deborah Meyers Sven Michel Hamida Mohamdi Arthur W Musk Rachel A Myers Maartje A E Nieuwenhuis Emiko Noguchi George T O'Connor Ludmila M Ogorodova Cameron D Palmer Aarno Palotie Julie E Park Craig E Pennell Göran Pershagen Alexey Polonikov Dirkje S Postma Nicole Probst-Hensch Valery P Puzyrev Benjamin A Raby Olli T Raitakari Adaikalavan Ramasamy Stephen S Rich Colin F Robertson Isabelle Romieu Muhammad T Salam Veikko Salomaa Vivi Schlünssen Robert Scott Polina A Selivanova Torben Sigsgaard Angela Simpson Valérie Siroux Lewis J Smith Maria Solodilova Marie Standl Kari Stefansson David P Strachan Bruno H Stricker Atsushi Takahashi Philip J Thompson Gudmar Thorleifsson Unnur Thorsteinsdottir Carla M T Tiesler Dara G Torgerson Tatsuhiko Tsunoda André G Uitterlinden Ralf J P van der Valk Amaury Vaysse Sailaja Vedantam Andrea von Berg Erika von Mutius Judith M Vonk Johannes Waage Nick J Wareham Scott T Weiss Wendy B White Magnus Wickman Elisabeth Widén Gonneke Willemsen L Keoki Williams Inge M Wouters James J Yang Jing Hua Zhao Miriam F Moffatt Carole Ober Dan L Nicolae

Nat Genet 2018 01 22;50(1):42-53. Epub 2017 Dec 22.

Departments of Statistics, Human Genetics and Medicine, Section of Genetic Medicine, University of Chicago, Chicago, IL, USA.

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http://www.nature.com/articles/s41588-017-0014-7
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http://dx.doi.org/10.1038/s41588-017-0014-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901974PMC
January 2018

Vitamin D levels and susceptibility to asthma, elevated immunoglobulin E levels, and atopic dermatitis: A Mendelian randomization study.

PLoS Med 2017 05 9;14(5):e1002294. Epub 2017 May 9.

Centre for Clinical Epidemiology, Department of Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montréal, Canada.

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http://dx.doi.org/10.1371/journal.pmed.1002294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423551PMC
May 2017

Gain of power of the general regression model compared to Cochran-Armitage Trend tests: simulation study and application to bipolar disorder.

BMC Genet 2017 03 10;18(1):24. Epub 2017 Mar 10.

Inserm Siège, Université Paris Diderot, Université Sorbonne Paris Cité, Paris, France.

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http://dx.doi.org/10.1186/s12863-017-0486-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5345257PMC
March 2017

DNA methylation within melatonin receptor 1A (MTNR1A) mediates paternally transmitted genetic variant effect on asthma plus rhinitis.

J Allergy Clin Immunol 2016 09 30;138(3):748-753. Epub 2016 Mar 30.

INSERM, UMR946, Genetic Variation and Human Diseases Unit, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2015.12.1341DOI Listing
September 2016

Interaction between the DNAH9 gene and early smoke exposure in bronchial hyperresponsiveness.

Eur Respir J 2016 Apr 21;47(4):1072-81. Epub 2016 Jan 21.

INSERM, UMR 946, Genetic Variation and Human Diseases Unit, Paris, France Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie, Paris, France.

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http://dx.doi.org/10.1183/13993003.00849-2015DOI Listing
April 2016

Unsupervised text mining for assessing and augmenting GWAS results.

J Biomed Inform 2016 Apr 19;60:252-9. Epub 2016 Feb 19.

INSERM, Genetic Variation and Human Diseases Unit, UMR-946, Paris F-75010, France; Institut Universitaire d'Hématologie, Université Paris Diderot, Sorbonne Paris Cité, Paris F-75010, France.

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http://dx.doi.org/10.1016/j.jbi.2016.02.008DOI Listing
April 2016

Meta-analysis identifies seven susceptibility loci involved in the atopic march.

Nat Commun 2015 Nov 6;6:8804. Epub 2015 Nov 6.

Max-Delbrück-Center (MDC) for Molecular Medicine, Berlin, Germany.

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http://dx.doi.org/10.1038/ncomms9804DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4667629PMC
November 2015

Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma.

Nat Genet 2015 Sep 3;47(9):987-995. Epub 2015 Aug 3.

Section of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, UK.

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http://dx.doi.org/10.1038/ng.3373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4557485PMC
September 2015

The effect on melanoma risk of genes previously associated with telomere length.

J Natl Cancer Inst 2014 Oct 17;106(10). Epub 2014 Sep 17.

Section of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, Leeds Cancer Research UK Centre, University of Leeds, Leeds, UK (MMI, DTB, JCT, MHa, JRM, JANB, JHB); Oncogenomics (NKH), Genetic Epidemiology (NGM), Inflammatory Bowel Diseases Laboratory (GLRS), Cancer Control Group (DCW), Statistical Genetics (SM, MHL), and Molecular Epidemiology (GWM), QIMR Berghofer Medical Research Institute, Brisbane, Australia; INSERM, UMR-946, Genetic Variation and Human Diseases Unit, Paris, France (MB, FD); Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie, Paris, France (MB, FD); Cancer Epidemiology and Services Research, Sydney School of Public Health, University of Sydney, Australia (AEC); Department of Oncology, University of Cambridge, Cambridge, UK (AMD, PDPP); Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX (JEL); Centre for Genetic Origins of Health and Disease, Faculty of Medicine, Dentistry and Health Sciences, University of Western Australia, Crawley, Australia (EKM, SVW); Centre for Cancer Biomarkers CCBIO (LAA) and Gade Laboratory for Pathology (AM), Department of Clinical Medicine, University of Bergen, Bergen, Norway; Department of Pathology, Haukeland University Hospital, Bergen, Norway (LAA); Department of Pathology, Molecular Pathology (PAA) and Department of Dermatology (PH), Oslo University Hospital, Rikshospitalet, Oslo, Norway; Assistance Publique-Hôpitaux de Paris, Hôpital Cochin, Service de Dermatologie, Université Paris Descartes, Paris, France (MFA); Department of Dermatology (EA) and Oncogenics Unit (EA, EF), Sheba Medical Center, Tel Hashomer, Sackler Faculty of Medicine, Tel Aviv, Israel (EA); Department of Internal Medicine and Medical Specialties, University of Genoa, Genoa, Italy (GBS, EFPG); Laboratory of Genetics of Rare Hereditary Cancers, San Martino-IST Research Hospital, Genoa, Italy (GBS, EFPG); Division of Cancer Epidemiology and Gene

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https://genepi.qimr.edu.au/contents/p/staff/IlesMM_JNCI_EPUB
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http://jnci.oxfordjournals.org/cgi/doi/10.1093/jnci/dju267
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http://dx.doi.org/10.1093/jnci/dju267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196080PMC
October 2014

The nuclear factor I/A (NFIA) gene is associated with the asthma plus rhinitis phenotype.

J Allergy Clin Immunol 2014 Sep 20;134(3):576-582.e1. Epub 2014 Feb 20.

INSERM U946, Genetic Variation and Human Diseases Unit, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie, Paris, France.

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http://dx.doi.org/10.1016/j.jaci.2013.12.1074DOI Listing
September 2014

Novel childhood asthma genes interact with in utero and early-life tobacco smoke exposure.

J Allergy Clin Immunol 2014 Mar 6;133(3):885-8. Epub 2013 Dec 6.

Department of Epidemiology, University of Groningen, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Groningen Research Institute for Asthma and COPD (GRIAC), University of Groningen, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2013.08.049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969577PMC
March 2014

A common 16p11.2 inversion underlies the joint susceptibility to asthma and obesity.

Am J Hum Genet 2014 Mar 20;94(3):361-72. Epub 2014 Feb 20.

Hospital del Mar Research Institute (IMIM), Barcelona 08003, Spain; Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona 08003, Spain; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Barcelona 08003, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2014.01.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951940PMC
March 2014

Selection of genes for gene-environment interaction studies: a candidate pathway-based strategy using asthma as an example.

Environ Health 2013 Jul 3;12:56. Epub 2013 Jul 3.

Inserm, Centre for research in Epidemiology and Population Health (CESP), U1018, Respiratory and Environmental Epidemiology Team, F-94807, Paris, Villejuif, France.

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http://dx.doi.org/10.1186/1476-069X-12-56DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708788PMC
July 2013

A variant in FTO shows association with melanoma risk not due to BMI.

Nat Genet 2013 Apr 3;45(4):428-32, 432e1. Epub 2013 Mar 3.

Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, Leeds Cancer Research UK Centre, St. James's University Hospital, Leeds, UK.

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https://genepi.qimr.edu.au/contents/p/staff/Iles_etal_Nature
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http://www.nature.com/doifinder/10.1038/ng.2571
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http://dx.doi.org/10.1038/ng.2571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640814PMC
April 2013

Comparative power of family-based association strategies to detect disease-causing variants under two-locus models.

Genet Epidemiol 2012 Dec 9;36(8):848-55. Epub 2012 Aug 9.

INSERM, UMR-S946, Fondation Jean Dausset-CEPH, Paris, France; Univ Paris-Diderot, PRES Sorbonne Paris Cité, Institut Universitaire d'Hématologie, UMR-S946, Paris, France.

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http://doi.wiley.com/10.1002/gepi.21672
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http://dx.doi.org/10.1002/gepi.21672DOI Listing
December 2012

Gene-environment interactions in asthma and allergic diseases: challenges and perspectives.

J Allergy Clin Immunol 2012 Dec;130(6):1229-40; quiz 1241-2

INSERM, CESP Centre for research in Epidemiology and Population Health, U1018, Respiratory and Environmental Epidemiology Team, Villejuif, France.

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http://dx.doi.org/10.1016/j.jaci.2012.10.038DOI Listing
December 2012

Genetic and functional evaluation of MITF as a candidate gene for cutaneous melanoma predisposition in pigs.

Mamm Genome 2011 Oct 28;22(9-10):602-12. Epub 2011 May 28.

INRA, UMR Génétique Animale et Biologie Intégrative, Equipe Génétique Immunité Santé, 78352 Jouy-en-Josas, France.

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http://dx.doi.org/10.1007/s00335-011-9334-6DOI Listing
October 2011

Genome-wide association study identifies three new melanoma susceptibility loci.

Nat Genet 2011 Oct 9;43(11):1108-13. Epub 2011 Oct 9.

Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, Leeds Cancer Research UK Centre, St James’s University Hospital, Leeds, UK.

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http://dx.doi.org/10.1038/ng.959DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3251256PMC
October 2011

A SUMOylation-defective MITF germline mutation predisposes to melanoma and renal carcinoma.

Authors:
Corine Bertolotto Fabienne Lesueur Sandy Giuliano Thomas Strub Mahaut de Lichy Karine Bille Philippe Dessen Benoit d'Hayer Hamida Mohamdi Audrey Remenieras Eve Maubec Arnaud de la Fouchardière Vincent Molinié Pierre Vabres Stéphane Dalle Nicolas Poulalhon Tanguy Martin-Denavit Luc Thomas Pascale Andry-Benzaquen Nicolas Dupin Françoise Boitier Annick Rossi Jean-Luc Perrot Bruno Labeille Caroline Robert Bernard Escudier Olivier Caron Laurence Brugières Simon Saule Betty Gardie Sophie Gad Stéphane Richard Jérôme Couturier Bin Tean Teh Paola Ghiorzo Lorenza Pastorino Susana Puig Celia Badenas Hakan Olsson Christian Ingvar Etienne Rouleau Rosette Lidereau Philippe Bahadoran Philippe Vielh Eve Corda Hélène Blanché Diana Zelenika Pilar Galan François Aubin Bertrand Bachollet Céline Becuwe Pascaline Berthet Yves Jean Bignon Valérie Bonadona Jean-Louis Bonafe Marie-Noëlle Bonnet-Dupeyron Fréderic Cambazard Jacqueline Chevrant-Breton Isabelle Coupier Sophie Dalac Liliane Demange Michel d'Incan Catherine Dugast Laurence Faivre Lynda Vincent-Fétita Marion Gauthier-Villars Brigitte Gilbert Florent Grange Jean-Jacques Grob Philippe Humbert Nicolas Janin Pascal Joly Delphine Kerob Christine Lasset Dominique Leroux Julien Levang Jean-Marc Limacher Cristina Livideanu Michel Longy Alain Lortholary Dominique Stoppa-Lyonnet Sandrine Mansard Ludovic Mansuy Karine Marrou Christine Matéus Christine Maugard Nicolas Meyer Catherine Nogues Pierre Souteyrand Laurence Venat-Bouvet Hélène Zattara Valérie Chaudru Gilbert M Lenoir Mark Lathrop Irwin Davidson Marie-Françoise Avril Florence Demenais Robert Ballotti Brigitte Bressac-de Paillerets

Nature 2011 Oct 19;480(7375):94-8. Epub 2011 Oct 19.

1] INSERM, U895 (équipe 1), Equipe labélisée Ligue Contre le Cancer, C3M, 06204 Nice, France [2] Université of Nice Sophia-Antipolis, UFR Médecine, 06204 Nice, France [3] Centre Hospitalier Universitaire de Nice, Service de Dermatologie, 06204 Nice, France [4].

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http://dx.doi.org/10.1038/nature10539DOI Listing
October 2011

Mold allergen sensitization in adult asthma according to integrin β3 polymorphisms and Toll-like receptor 2/+596 genotype.

J Allergy Clin Immunol 2011 Jul 13;128(1):185-191.e7. Epub 2011 May 13.

Institute for Risk Assessment Sciences, Division of Environmental Epidemiology, Utrecht University, Utrecht, The Netherlands.

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http://dx.doi.org/10.1016/j.jaci.2011.04.007DOI Listing
July 2011

A large-scale, consortium-based genomewide association study of asthma.

N Engl J Med 2010 Sep;363(13):1211-1221

National Heart and Lung Institute, Imperial College (M.F.M., W.O.C.M.C.), the Division of Community Health Sciences, St. George's, University of London (D.P.S.), and Royal Brompton and Harefield NHS Foundation Trust (W.O.C.M.C.) - all in London; Commissariat à l'Energie Atomique, Institut de Génomique, Centre National de Génotypage, Evry, France (I.G.G., S.H., M.L.); INSERM, Unité 946, Fondation Jean-Dausset-Centre d'Etude du Polymorphisme Humain (CEPH) (F.D., E.B.), Fondation Jean Dausset-CEPH (F.D., E.B., M.L.), and Université Paris Diderot Paris 7, Institut Universitaire d'Hématologie (F.D., E.B.) - all in Paris; University Children's Hospital, Asthma and Allergy Department, Ludwig Maximilians University, Munich, Germany (E.M.); and Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom (M.F.).

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http://dx.doi.org/10.1056/NEJMoa0906312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260321PMC
September 2010

A two-step multiple-marker strategy for genome-wide association studies.

BMC Proc 2007 18;1 Suppl 1:S134. Epub 2007 Dec 18.

INSERM, U794, Tour Evry 2, 523 Place des Terrasses de l'Agora, 91034, Evry, France.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2367542PMC
http://dx.doi.org/10.1186/1753-6561-1-s1-s134DOI Listing
December 2009

MC1R variant alleles and malignant melanoma risk in Israel.

Eur J Cancer 2009 Jul 5;45(11):2015-22. Epub 2009 Mar 5.

The Susanne Levy Gertner Oncogenetic Unit, The Danek Gertner Institute of Human Genetics, Chaim Sheba Medical Center, Tel-Hashomer 52621, Israel.

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http://dx.doi.org/10.1016/j.ejca.2009.02.001DOI Listing
July 2009

Replication of association between ADAM33 polymorphisms and psoriasis.

PLoS One 2008 Jun 18;3(6):e2448. Epub 2008 Jun 18.

Inserm, U823, Centre de Recherche Albert Bonniot, Epidémiologie des cancers et des affections graves, La Tronche, France.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0002448PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2413006PMC
June 2008

Melanocortin-1 receptor (MC1R) gene variants and dysplastic nevi modify penetrance of CDKN2A mutations in French melanoma-prone pedigrees.

Cancer Epidemiol Biomarkers Prev 2005 Oct;14(10):2384-90

Institut National de la Sante et de la Recherche Medicale, Université d'Evry, EMI 0006, Tour Evry 2, 523 Place des Terrasses de l'Agora, 91034 Evry, France.

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http://dx.doi.org/10.1158/1055-9965.EPI-04-0777DOI Listing
October 2005

[Genetics of asthma and atopy: how many genes?].

Bull Acad Natl Med 2005 Oct;189(7):1435-48

INSERM-Université d'Evry EMI0006, Tour Evry2, 523 place des Terrasses de l'Agora, 91034 Evry Cedex.

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October 2005

Using an age-at-onset phenotype with interval censoring to compare methods of segregation and linkage analysis in a candidate region for elevated systolic blood pressure.

BMC Genet 2003 Dec 31;4 Suppl 1:S84. Epub 2003 Dec 31.

Samuel Lunenfeld Research Institute of Mount Sinai Hospital, 60 Murray Street, 5th Floor, Toronto, Ontario, M5G 1X5, Canada.

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http://bmcgenet.biomedcentral.com/articles/10.1186/1471-2156
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http://dx.doi.org/10.1186/1471-2156-4-S1-S84DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1866524PMC
December 2003

Genetic and environmental factors in cutaneous malignant melanoma.

Biochimie 2002 Jan;84(1):67-74

Service de génétique, Institut Gustave Roussy, Villejuif, France.

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http://dx.doi.org/10.1016/s0300-9084(01)01360-8DOI Listing
January 2002