Flint Beal

Flint Beal

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Flint Beal

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PGC-1α, Sirtuins and PARPs in Huntington's Disease and Other Neurodegenerative Conditions: NAD+ to Rule Them All.

Neurochem Res 2019 Oct 7;44(10):2423-2434. Epub 2019 May 7.

Feil Family Brain and Mind Research Institute, Weill Cornell Medical College, 1400 York Street, 5th Floor, Room A-501, New York, NY, 10065, USA.

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http://dx.doi.org/10.1007/s11064-019-02809-1DOI Listing
October 2019

Mitochondrial dysfunction and oxidative stress in induced pluripotent stem cell models of Parkinson's disease.

Eur J Neurosci 2019 Feb 1;49(4):525-532. Epub 2018 Dec 1.

Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, New York.

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http://dx.doi.org/10.1111/ejn.14264DOI Listing
February 2019

Determination of Coenzyme A and Acetyl-Coenzyme A in Biological Samples Using HPLC with UV Detection.

Molecules 2017 Aug 23;22(9). Epub 2017 Aug 23.

Bach Institute of Biochemistry, Research Center of Biotechnology of the Russian Academy of Sciences, Moscow 119071, Russia.

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http://dx.doi.org/10.3390/molecules22091388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151540PMC
August 2017

A randomized, double-blind, placebo-controlled trial of coenzyme Q10 in Huntington disease.

Neurology 2017 Jan 2;88(2):152-159. Epub 2016 Dec 2.

From Cooper University Healthcare at Rowan University (A.M.), Camden, NJ; University of Rochester (M.M., K.K., E.A.d.B., K.B., P.C.); Weill Cornell Medical Center (F.B.); Columbia Presbyterian Medical Center (K.M.), New York, NY; Johns Hopkins Medical Center (C.R.), Baltimore, MD; Georgetown University (I.S.), Washington, DC; NINDS (P.G.), Bethesda, MD; Hereditary Neurological Disease Center (W.M.M.), Wichita, KS; The Centre for Movement Disorders (M.G.), Toronto, Canada; Indiana University School of Medicine (J.W.), Indianapolis; Colorado Neurological Institute (R.K.), Englewood; University of Tennessee Health Science Center (M.S.L.), Memphis; London Health Sciences Centre (M.J.), Canada; Massachusetts General Hospital (H.D.R.), Boston; Struthers Parkinson's Center (M.N.), Minneapolis, MN; University of Kansas Medical Center (R.M.D.), Kansas City; Rush University Medical Center (K.M.S.), Chicago, IL; University of Texas Southwestern Medical Center (P.O.), Dallas; University of Michigan (K.C.), Ann Arbor; Wake Forest University (F.W.), Winston-Salem, NC; University of Alberta (W.M.), Edmonton, Canada; University of California Davis (V.L.W.), Sacramento; Westmead Hospital (E. McCusker), Westmead, Australia; Baylor College of Medicine (J.J.), Houston, TX; University of Miami Miller School of Medicine (C.S.), FL; University of South Florida (J.S.-R.), Tampa; Duke University (B.S.), Durham, NC; University of Calgary (O.S.), Canada; Emory University School of Medicine (S.A.F.), Atlanta, GA; Albany Medical College (D.S.H., Eric Molho), NY; University of Cincinnati (F.R.), OH; Mayo Clinic Arizona (J.N.C.), Scottsdale; Butler Hospital (J.H.F.), Providence, RI; Washington University (J.S.P.), St. Louis, MO; Feinstein Institute for Medical Research (A.F.), Manhasset, NY; Georgetown University (K.A.), Washington, DC; University of Florida (R.R., N.R.M.), Gainesville; Johns Hopkins University (R.L.M.), Baltimore, MD; University of Nevada School of Medicine (E.S.F.), Reno; University of British Columbia (L.A.R.), Vancouver, Canada; University of Pittsburgh (V.S.), PA; Ohio State University (S.K.), Columbus; The Cooper University Health System (A.C.), Camden, NJ; Idaho Elks Rehabilitation Hospital (L.S.), Boise, ID; University of Iowa (E.E.), Iowa City; North York General Hospital 1 (S.E.), Toronto, Canada; St. Luke's Hospital (N.D.), Allentown, PA; North York General Hospital 2 (W.L.A.F.), University of Toronto, Canada; Washington Regional Medical Center (A.D.), Fayetteville, AR; Beth-Israel Deaconess Medical Center (S.F.), Boston, MA; NJ Neuroscience Institute (P.H.), Edison; University of California Irvine (N.H.); The University of Alabama at Birmingham (L.S.D.); and Massachusetts General Hospital (M.C.), Harvard Medical School, Boston.

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http://dx.doi.org/10.1212/WNL.0000000000003478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224719PMC
January 2017

Reductions in the mitochondrial enzyme α-ketoglutarate dehydrogenase complex in neurodegenerative disease - beneficial or detrimental?

J Neurochem 2016 12;139(5):823-838

Brain and Mind Research Institute, Weill Cornell Medical College, Burke Medical Research Institute, White Plains, New York, USA.

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http://dx.doi.org/10.1111/jnc.13836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123932PMC
December 2016

Mitochondrial dysfunction in Parkinson's disease.

J Neurochem 2016 10 21;139 Suppl 1:216-231. Epub 2016 Aug 21.

Brain and Mind Research Institute, Weill Cornell Medicine, New York City, New York, USA.

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http://dx.doi.org/10.1111/jnc.13731DOI Listing
October 2016

Simultaneous determination of tricarboxylic acid cycle metabolites by high-performance liquid chromatography with ultraviolet detection.

Anal Biochem 2016 06 19;503:8-10. Epub 2016 Mar 19.

Bach Institute of Biochemistry, Research Center of Biotechnology of the Russian Academy of Sciences, Moscow 119071, Russia; Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA.

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http://dx.doi.org/10.1016/j.ab.2016.03.004DOI Listing
June 2016

Enhanced mitochondrial biogenesis ameliorates disease phenotype in a full-length mouse model of Huntington's disease.

Hum Mol Genet 2016 06 22;25(11):2269-2282. Epub 2016 Mar 22.

Feil Family Brain and Mind Research Institute, Weill Cornell Medical College, New York, NY 10065, USA

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http://dx.doi.org/10.1093/hmg/ddw095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081058PMC
June 2016

HPLC determination of α-ketoglutaramate [5-amino-2,5-dioxopentanoate] in biological samples.

Anal Biochem 2016 Feb 11;494:52-4. Epub 2015 Nov 11.

Bach Institute of Biochemistry, Research Center of Biotechnology of the Russian Academy of Sciences, 33, bld. 2 Leninsky Ave., Moscow 119071, Russia; Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA.

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http://dx.doi.org/10.1016/j.ab.2015.11.003DOI Listing
February 2016

Preferential PPAR-α activation reduces neuroinflammation, and blocks neurodegeneration in vivo.

Hum Mol Genet 2016 Jan 24;25(2):317-27. Epub 2015 Nov 24.

Department of Neurobiology and Developmental Sciences, Center for Translational Neuroscience and,

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http://dx.doi.org/10.1093/hmg/ddv477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4706116PMC
January 2016

Usefulness of proton and phosphorus MR spectroscopic imaging for early diagnosis of Parkinson's disease.

J Neuroimaging 2015 Jan-Feb;25(1):105-10. Epub 2013 Dec 10.

Department of Radiology, Weill Cornell Medical College, New York, NY.

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http://dx.doi.org/10.1111/jon.12074DOI Listing
September 2015

Lack of exacerbation of neurodegeneration in a double transgenic mouse model of mutant LRRK2 and tau.

Hum Mol Genet 2015 Jun 24;24(12):3545-56. Epub 2015 Mar 24.

Department of Neurology and Neuroscience, Weill Cornell Medical College, New York, NY 10065, USA.

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https://academic.oup.com/hmg/article-lookup/doi/10.1093/hmg/
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http://dx.doi.org/10.1093/hmg/ddv105DOI Listing
June 2015

Impaired brain energy metabolism in the BACHD mouse model of Huntington's disease: critical role of astrocyte-neuron interactions.

J Cereb Blood Flow Metab 2014 Sep 18;34(9):1500-10. Epub 2014 Jun 18.

Commissariat à l'Energie Atomique et aux Energies Alternatives (CEA), Département des Sciences du Vivant (DSV), Institut d'Imagerie Biomédicale (I2BM), Molecular Imaging Research Center (MIRCen) and CNRS CEA URA 2210, Fontenay-aux-Roses, France.

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http://dx.doi.org/10.1038/jcbfm.2014.110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158666PMC
September 2014

Methylene blue upregulates Nrf2/ARE genes and prevents tau-related neurotoxicity.

Hum Mol Genet 2014 Jul 20;23(14):3716-32. Epub 2014 Feb 20.

Department of Neurology and Neuroscience, Weill Cornell Medical College, New York, NY 10065, USA, IHU-A-ICM, Hospital Pitié-Salpêtrière, 75013 Paris, France

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http://dx.doi.org/10.1093/hmg/ddu080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4065148PMC
July 2014

Sex differences in cerebral energy metabolism in Parkinson's disease: a phosphorus magnetic resonance spectroscopic imaging study.

Parkinsonism Relat Disord 2014 May 13;20(5):545-8. Epub 2014 Feb 13.

Neurology, Weill Cornell Medical College, New York, NY 10021, United States. Electronic address:

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http://dx.doi.org/10.1016/j.parkreldis.2014.02.003DOI Listing
May 2014

A randomized clinical trial of high-dosage coenzyme Q10 in early Parkinson disease: no evidence of benefit.

Authors:
M Flint Beal David Oakes Ira Shoulson Claire Henchcliffe Wendy R Galpern Richard Haas Jorge L Juncos John G Nutt Tiffini Smith Voss Bernard Ravina Clifford M Shults Karen Helles Victoria Snively Mark F Lew Brian Griebner Arthur Watts Shan Gao Emmanuelle Pourcher Louisette Bond Katie Kompoliti Pinky Agarwal Cherissa Sia Mandar Jog Linda Cole Munira Sultana Roger Kurlan Irene Richard Cheryl Deeley Cheryl H Waters Angel Figueroa Ani Arkun Matthew Brodsky William G Ondo Christine B Hunter Joohi Jimenez-Shahed Alicia Palao Janis M Miyasaki Julie So James Tetrud Liza Reys Katharine Smith Carlos Singer Anita Blenke David S Russell Candace Cotto Joseph H Friedman Margaret Lannon Lin Zhang Edward Drasby Rajeev Kumar Thyagarajan Subramanian Donna Stuppy Ford David A Grimes Diane Cote Jennifer Conway Andrew D Siderowf Marian Leslie Evatt Barbara Sommerfeld Abraham N Lieberman Michael S Okun Ramon L Rodriguez Stacy Merritt Camille Louise Swartz W R Wayne Martin Pamela King Natividad Stover Stephanie Guthrie Ray L Watts Anwar Ahmed Hubert H Fernandez Adrienna Winters Zoltan Mari Ted M Dawson Becky Dunlop Andrew S Feigin Barbara Shannon Melissa Jill Nirenberg Mattson Ogg Samuel A Ellias Cathi-Ann Thomas Karen Frei Ivan Bodis-Wollner Sofya Glazman Thomas Mayer Robert A Hauser Rajesh Pahwa April Langhammer Ranjit Ranawaya Lorelei Derwent Kapil D Sethi Buff Farrow Rajan Prakash Irene Litvan Annette Robinson Alok Sahay Maureen Gartner Vanessa K Hinson Samuel Markind Melisa Pelikan Joel S Perlmutter Johanna Hartlein Eric Molho Sharon Evans Charles H Adler Amy Duffy Marlene Lind Lawrence Elmer Kathy Davis Julia Spears Stephanie Wilson Maureen A Leehey Neal Hermanowicz Shari Niswonger Holly A Shill Sanja Obradov Alex Rajput Marilyn Cowper Stephanie Lessig David Song Deborah Fontaine Cindy Zadikoff Karen Williams Karen A Blindauer Jo Bergholte Clara Schindler Propsom Mark A Stacy Joanne Field Dragos Mihaila Mark Chilton Ergun Y Uc Jeri Sieren David K Simon Lauren Kraics Althea Silver James T Boyd Robert W Hamill Christopher Ingvoldstad Jennifer Young Karen Thomas Sandra K Kostyk Joanne Wojcieszek Ronald F Pfeiffer Michel Panisset Monica Beland Stephen G Reich Michelle Cines Nancy Zappala Jean Rivest Richard Zweig L Pepper Lumina Colette Lynn Hilliard Stephen Grill Marye Kellermann Paul Tuite Susan Rolandelli Un Jung Kang Joan Young Jayaraman Rao Maureen M Cook Lawrence Severt Karyn Boyar

JAMA Neurol 2014 May;71(5):543-52

Department of Neurology, Beth Israel Medical Center, New York, New York.

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http://dx.doi.org/10.1001/jamaneurol.2014.131DOI Listing
May 2014

Coordinate regulation of mature dopaminergic axon morphology by macroautophagy and the PTEN signaling pathway.

PLoS Genet 2013 3;9(10):e1003845. Epub 2013 Oct 3.

Departments of Pathology and Neurology, Taub Institute, Columbia University Medical Center, New York, New York, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1003845DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789823PMC
March 2014

Prospects for neuroprotective therapies in prodromal Huntington's disease.

Mov Disord 2014 Mar 26;29(3):285-93. Epub 2014 Feb 26.

Brain and Mind Research Institute, Weill Medical College of Cornell University, New York Presbyterian Hospital, New York, New York, USA.

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http://dx.doi.org/10.1002/mds.25835DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624289PMC
March 2014

Mitochondrial diseases of the brain.

Free Radic Biol Med 2013 Oct 6;63:1-29. Epub 2013 Apr 6.

CSIR-Indian Institute of Toxicology Research, 80 MG Marg, Lucknow 226001, India.

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http://dx.doi.org/10.1016/j.freeradbiomed.2013.03.018DOI Listing
October 2013

PGC-1α, mitochondrial dysfunction, and Huntington's disease.

Free Radic Biol Med 2013 Sep 19;62:37-46. Epub 2013 Apr 19.

Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York-Presbyterian Hospital, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.freeradbiomed.2013.04.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3722269PMC
September 2013

Mitochondria targeted therapeutic approaches in Parkinson's and Huntington's diseases.

Mol Cell Neurosci 2013 Jul 5;55:101-14. Epub 2012 Dec 5.

Developmental Toxicology Division, Systems Toxicology Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), 80 MG Marg, Lucknow 226001, India.

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http://dx.doi.org/10.1016/j.mcn.2012.11.011DOI Listing
July 2013

Neuroprotection by cyclodextrin in cell and mouse models of Alzheimer disease.

J Exp Med 2012 Dec 3;209(13):2501-13. Epub 2012 Dec 3.

Department of Neurology and Neuroscience, Weill Cornell Medical College, New York, NY 10065, USA.

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http://dx.doi.org/10.1084/jem.20121239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526350PMC
December 2012

Huntington's disease.

Handb Clin Neurol 2012 ;106:507-26

Sigmund Freud University, Vienna, Austria.

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http://dx.doi.org/10.1016/B978-0-444-52002-9.00030-9DOI Listing
November 2012

Behavioral improvement after chronic administration of coenzyme Q10 in P301S transgenic mice.

J Alzheimers Dis 2012 ;28(1):173-82

Weill Cornell Medical College, Department of Neurology and Neuroscience, New York, NY, USA.

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http://dx.doi.org/10.3233/JAD-2011-111190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279177PMC
September 2012

Concordant signaling pathways produced by pesticide exposure in mice correspond to pathways identified in human Parkinson's disease.

PLoS One 2012 1;7(5):e36191. Epub 2012 May 1.

Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0036191PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341364PMC
September 2012

Mitochondrial dysfunction in neurodegenerative diseases.

J Pharmacol Exp Ther 2012 Sep 13;342(3):619-30. Epub 2012 Jun 13.

Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY, USA.

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http://dx.doi.org/10.1124/jpet.112.192138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422529PMC
September 2012

Transducer of regulated CREB-binding proteins (TORCs) transcription and function is impaired in Huntington's disease.

Hum Mol Genet 2012 Aug 15;21(15):3474-88. Epub 2012 May 15.

Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York-Presbyterian Hospital, New York, NY 10065, USA.

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http://dx.doi.org/10.1093/hmg/dds178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491961PMC
August 2012

Oral repeated-dose toxicity studies of coenzyme Q10 in beagle dogs.

Int J Toxicol 2012 Jan-Feb;31(1):58-69. Epub 2012 Jan 20.

Neurology Clinical Trials Unit, Massachusetts General Hospital, 13th Street, Building 149, Room 2274, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1177/1091581811425256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288259PMC
June 2012

NADPH oxidase 1-mediated oxidative stress leads to dopamine neuron death in Parkinson's disease.

Antioxid Redox Signal 2012 May 25;16(10):1033-45. Epub 2012 Jan 25.

Neurology/Neuroscience Department, Weill Medical College of Cornell University, New York, New York, USA.

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http://dx.doi.org/10.1089/ars.2011.3960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315177PMC
May 2012

Antioxidants in Huntington's disease.

Biochim Biophys Acta 2012 May 23;1822(5):664-74. Epub 2011 Nov 23.

Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York-Presbyterian Hospital, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.bbadis.2011.11.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303936PMC
May 2012

Muscling in on PGC-1α for improved quality of life in ALS.

Cell Metab 2012 May;15(5):567-9

Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York-Presbyterian Hospital, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.cmet.2012.04.015DOI Listing
May 2012

A neuroprotective role of the human uncoupling protein 2 (hUCP2) in a Drosophila Parkinson's disease model.

Neurobiol Dis 2012 Apr 13;46(1):137-46. Epub 2012 Jan 13.

Department of Allied Health Sciences, University of Connecticut, 358 Mansfield Road, Storrs, CT 06269, USA.

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http://dx.doi.org/10.1016/j.nbd.2011.12.055DOI Listing
April 2012

Impaired mitochondrial function in psychiatric disorders.

Nat Rev Neurosci 2012 Apr 18;13(5):293-307. Epub 2012 Apr 18.

Janssen Research & Development, LLC, Raritan, New Jersey 08869, USA.

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http://dx.doi.org/10.1038/nrn3229DOI Listing
April 2012

Pharmacologic activation of mitochondrial biogenesis exerts widespread beneficial effects in a transgenic mouse model of Huntington's disease.

Hum Mol Genet 2012 Mar 17;21(5):1124-37. Epub 2011 Nov 17.

Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York-Presbyterian Hospital, New York, NY 10065, USA.

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http://dx.doi.org/10.1093/hmg/ddr541DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3277311PMC
March 2012

Truncated peroxisome proliferator-activated receptor-γ coactivator 1α splice variant is severely altered in Huntington's disease.

Neurodegener Dis 2011 15;8(6):496-503. Epub 2011 Jul 15.

Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY 10065, USA. asj2002 @ med.cornell.edu

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http://dx.doi.org/10.1159/000327910DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3186722PMC
December 2011

Determination of neurotransmitter levels in models of Parkinson's disease by HPLC-ECD.

Methods Mol Biol 2011 ;793:401-15

Department of Neurology and Neuroscience, Weill Cornell Medical College, New York, NY, USA.

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http://dx.doi.org/10.1007/978-1-61779-328-8_27DOI Listing
December 2011

Biomarkers of Parkinson's disease and Dementia with Lewy bodies.

Prog Neurobiol 2011 Dec 19;95(4):601-13. Epub 2011 Sep 19.

Weill Medical College of Cornell University, New York, NY, USA.

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http://dx.doi.org/10.1016/j.pneurobio.2011.09.002DOI Listing
December 2011

Behavioral deficit, oxidative stress, and mitochondrial dysfunction precede tau pathology in P301S transgenic mice.

FASEB J 2011 Nov 8;25(11):4063-72. Epub 2011 Aug 8.

Weill Cornell Medical College, Department of Neurology and Neuroscience, 525 East 68th St., Rm. A569A, New York, NY 10065, USA.

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http://dx.doi.org/10.1096/fj.11-186650DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3205832PMC
November 2011

Neuroprotective strategies involving ROS in Alzheimer disease.

Free Radic Biol Med 2011 Sep 1;51(5):1014-26. Epub 2010 Dec 1.

Department of Neurology and Neuroscience, Weill Cornell Medical College, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.freeradbiomed.2010.11.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3070183PMC
September 2011

Molecular insights into Parkinson's disease.

F1000 Med Rep 2011 1;3. Epub 2011 Apr 1.

Department of Neurology and Neuroscience, Weill Medical College of Cornell University 525 East 68th Street, A-501, New York, NY 10065 USA.

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http://dx.doi.org/10.3410/M3-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096887PMC
July 2011

DJ-1 cleavage by matrix metalloproteinase 3 mediates oxidative stress-induced dopaminergic cell death.

Antioxid Redox Signal 2011 Jun 10;14(11):2137-50. Epub 2011 Mar 10.

Neurology/Neuroscience Department, Weill Medical College of Cornell University, New York, New York, USA.

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http://dx.doi.org/10.1089/ars.2009.3059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4056461PMC
June 2011

Neuroprotective effects of creatine.

Authors:
M Flint Beal

Amino Acids 2011 May 30;40(5):1305-13. Epub 2011 Mar 30.

Department of Neurology and Neuroscience, Weill Cornell Medical College, 525 East 68th Street, New York, NY 10065, USA.

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http://dx.doi.org/10.1007/s00726-011-0851-0DOI Listing
May 2011

Coenzyme Q10 effects in neurodegenerative disease.

Neuropsychiatr Dis Treat 2009 16;5:597-610. Epub 2009 Nov 16.

Department of Neurology, Weill Medical, College of Cornell University, 525 east 68th Street, Suite F610, New York, NY, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2785862PMC
http://dx.doi.org/10.2147/ndt.s5212DOI Listing
April 2011

Apocynin administration does not improve behavioral and neuropathological deficits in a transgenic mouse model of Alzheimer's disease.

Neurosci Lett 2011 Apr 12;492(3):150-4. Epub 2011 Feb 12.

Weill Cornell Medical College, Department of Neurology and Neuroscience, 525 East 68th Street, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.neulet.2011.01.077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3086715PMC
April 2011

Role of matrix metalloproteinase 3-mediated alpha-synuclein cleavage in dopaminergic cell death.

J Biol Chem 2011 Apr 17;286(16):14168-77. Epub 2011 Feb 17.

Neurology/Neuroscience Department, Weill Medical College of Cornell University, New York, New York 10065, USA.

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http://dx.doi.org/10.1074/jbc.M111.222430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077618PMC
April 2011

Hugging tight in Huntington's.

Nat Med 2011 Mar;17(3):245-6

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http://dx.doi.org/10.1038/nm0311-245DOI Listing
March 2011

Autophagy in neurodegenerative disorders: pathogenic roles and therapeutic implications.

Trends Neurosci 2010 Dec 12;33(12):541-9. Epub 2010 Oct 12.

Department of Neurology and Neuroscience, Weill Medical College of Cornell University, 525 East 68(th) Street, A-501, New York, NY 10065.

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https://linkinghub.elsevier.com/retrieve/pii/S01662236100012
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http://dx.doi.org/10.1016/j.tins.2010.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2981680PMC
December 2010

MicroRNA-related cofilin abnormality in Alzheimer's disease.

PLoS One 2010 Dec 16;5(12):e15546. Epub 2010 Dec 16.

Department of Neurology, Weill-Cornell Medical College, New York, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0015546PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002958PMC
December 2010

Mitochondrial loss, dysfunction and altered dynamics in Huntington's disease.

Hum Mol Genet 2010 Oct 21;19(20):3919-35. Epub 2010 Jul 21.

Geriatric Research Education Clinical Center, New England Veterans Administration VISN 1, Bedford, MA 01730, USA.

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http://dx.doi.org/10.1093/hmg/ddq306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947400PMC
October 2010

Mitochondria and antioxidant targeted therapeutic strategies for Alzheimer's disease.

J Alzheimers Dis 2010 ;20 Suppl 2:S633-43

Weill Cornell Medical College, Department of Neurology and Neuroscience, New York, NY, USA.

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http://dx.doi.org/10.3233/JAD-2010-100507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098571PMC
September 2010

Resveratrol protects against peripheral deficits in a mouse model of Huntington's disease.

Exp Neurol 2010 Sep 1;225(1):74-84. Epub 2010 Jun 1.

Weill Cornell Medical College, Department of Neurology and Neuroscience, 525 E. 68th Street, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.expneurol.2010.05.006DOI Listing
September 2010

Parkinson's disease: a model dilemma.

Authors:
M Flint Beal

Nature 2010 Aug;466(7310):S8-10

Department of Neurology and Neuroscience at Weill Medical College.

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http://dx.doi.org/10.1038/466S8aDOI Listing
August 2010

Hunting-ton for new proteases: MMPs as the new target?

Neuron 2010 Jul;67(2):171-3

Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.neuron.2010.07.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3094731PMC
July 2010

Mitochondrial therapies for Parkinson's disease.

Mov Disord 2010 ;25 Suppl 1:S155-60

Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, New York 10065, USA.

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http://dx.doi.org/10.1002/mds.22781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797696PMC
June 2010

Cause and consequence: mitochondrial dysfunction initiates and propagates neuronal dysfunction, neuronal death and behavioral abnormalities in age-associated neurodegenerative diseases.

Biochim Biophys Acta 2010 Jan 26;1802(1):122-34. Epub 2009 Aug 26.

Department of Neurology and Neuroscience, Weill Cornell Medical College of Cornell University at Burke Medical Research Institute, 785 Mamaroneck Avenue, White Plains, NY 10605, USA.

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http://dx.doi.org/10.1016/j.bbadis.2009.08.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790547PMC
January 2010

Promethazine protects against 3-nitropropionic acid-induced neurotoxicity.

Neurochem Int 2010 Jan 21;56(2):208-12. Epub 2009 Oct 21.

Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York Presbyterian Hospital, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.neuint.2009.10.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4634881PMC
January 2010

N-iminoethyl-L-lysine improves memory and reduces amyloid pathology in a transgenic mouse model of amyloid deposition.

Neurochem Int 2010 Jan 13;56(2):345-51. Epub 2009 Nov 13.

Weill Cornell Medical College, Department of Neurology and Neuroscience, New York, NY 10065, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S019701860900311
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http://dx.doi.org/10.1016/j.neuint.2009.11.006DOI Listing
January 2010

Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice.

J Exp Med 2010 Jan 21;207(1):117-28. Epub 2009 Dec 21.

Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY 10065, USA.

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http://dx.doi.org/10.1084/jem.20091568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2812536PMC
January 2010

Therapeutic approaches to mitochondrial dysfunction in Parkinson's disease.

Authors:
M Flint Beal

Parkinsonism Relat Disord 2009 Dec;15 Suppl 3:S189-94

Department of Neurology & Neuroscience, Weill Cornell Medical College, New York, NY 10065-4870, USA.

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http://dx.doi.org/10.1016/S1353-8020(09)70812-0DOI Listing
December 2009

Lenalidomide (Revlimid) administration at symptom onset is neuroprotective in a mouse model of amyotrophic lateral sclerosis.

Exp Neurol 2009 Nov 4;220(1):191-7. Epub 2009 Sep 4.

Department of Neurology, Weill Medical College of Cornell University, New York-Presbyterian Hospital, New York, NY, USA.

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http://dx.doi.org/10.1016/j.expneurol.2009.08.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979314PMC
November 2009

Mitochondrial dihydrolipoyl succinyltransferase deficiency accelerates amyloid pathology and memory deficit in a transgenic mouse model of amyloid deposition.

Free Radic Biol Med 2009 Oct 22;47(7):1019-27. Epub 2009 Jul 22.

Department of Neurology and Neuroscience, Weill Cornell Medical College,New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.freeradbiomed.2009.07.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2761144PMC
October 2009

Metabolomic profiling in LRRK2-related Parkinson's disease.

PLoS One 2009 Oct 22;4(10):e7551. Epub 2009 Oct 22.

Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0007551PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2761616PMC
October 2009

The role of NADPH oxidase 1-derived reactive oxygen species in paraquat-mediated dopaminergic cell death.

Antioxid Redox Signal 2009 Sep;11(9):2105-18

Neurology/Neuroscience Department, Weill Medical College of Cornell University, New York, New York, USA.

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http://dx.doi.org/10.1089/ARS.2009.2459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2935343PMC
September 2009

Neuroprotective effects of compounds with antioxidant and anti-inflammatory properties in a Drosophila model of Parkinson's disease.

BMC Neurosci 2009 Sep 1;10:109. Epub 2009 Sep 1.

Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1186/1471-2202-10-109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3152779PMC
September 2009

Impaired PGC-1alpha function in muscle in Huntington's disease.

Hum Mol Genet 2009 Aug 21;18(16):3048-65. Epub 2009 May 21.

Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York-Presbyterian Hospital, New York, NY 10065, USA.

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http://dx.doi.org/10.1093/hmg/ddp243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2733807PMC
August 2009

Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease.

Nat Neurosci 2009 Jul 7;12(7):826-8. Epub 2009 Jun 7.

Department of Neurology and Neurosciences, Weill Medical College of Cornell University, New York, New York, USA.

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http://dx.doi.org/10.1038/nn.2349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845930PMC
July 2009

Combination therapy with coenzyme Q10 and creatine produces additive neuroprotective effects in models of Parkinson's and Huntington's diseases.

J Neurochem 2009 Jun 28;109(5):1427-39. Epub 2009 Mar 28.

Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York-Presbyterian Hospital, New York, New York 10021, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2009.06074.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866530PMC
June 2009