Fleur M Howells

Fleur M Howells

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Fleur M Howells

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The relationship between measurement of in vivo brain glutamate and markers of iron metabolism: A proton magnetic resonance spectroscopy study in healthy adults.

Eur J Neurosci 2019 Oct 4. Epub 2019 Oct 4.

Department of Psychiatry and Mental Health, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1111/ejn.14583DOI Listing
October 2019

Reply to: New Meta- and Mega-analyses of Magnetic Resonance Imaging Findings in Schizophrenia: Do They Really Increase Our Knowledge About the Nature of the Disease Process?

Authors:
Theo G M van Erp Esther Walton Derrek P Hibar Lianne Schmaal Wenhao Jiang David C Glahn Godfrey D Pearlson Nailin Yao Masaki Fukunaga Ryota Hashimoto Naohiro Okada Hidenaga Yamamori Vincent P Clark Bryon A Mueller Sonja M C de Zwarte Roel A Ophoff Neeltje E M van Haren Ole A Andreassen Tiril P Gurholt Oliver Gruber Bernd Kraemer Anja Richter Vince D Calhoun Benedicto Crespo-Facorro Roberto Roiz-Santiañez Diana Tordesillas-Gutiérrez Carmel Loughland Stanley Catts Janice M Fullerton Melissa J Green Frans Henskens Assen Jablensky Bryan J Mowry Christos Pantelis Yann Quidé Ulrich Schall Rodney J Scott Murray J Cairns Marc Seal Paul A Tooney Paul E Rasser Gavin Cooper Cynthia Shannon Weickert Thomas W Weickert Elliot Hong Peter Kochunov Raquel E Gur Ruben C Gur Judith M Ford Fabio Macciardi Daniel H Mathalon Steven G Potkin Adrian Preda Fengmei Fan Stefan Ehrlich Margaret D King Lieuwe De Haan Dick J Veltman Francesca Assogna Nerisa Banaj Pietro de Rossi Mariangela Iorio Fabrizio Piras Gianfranco Spalletta Edith Pomarol-Clotet Sinead Kelly Simone Ciufolini Joaquim Radua Robin Murray Tiago Reis Marques Andrew Simmons Stefan Borgwardt Fabienne Schönborn-Harrisberger Anita Riecher-Rössler Renata Smieskova Kathryn I Alpert Alessandro Bertolino Aurora Bonvino Annabella Di Giorgio Emma Neilson Andrew R Mayer Je-Yeon Yun Dara M Cannon Irina Lebedeva Alexander S Tomyshev Tolibjohn Akhadov Vasily Kaleda Helena Fatouros-Bergman Lena Flyckt Pedro G P Rosa Mauricio H Serpa Marcus V Zanetti Cyril Hoschl Antonin Skoch Filip Spaniel David Tomecek Andrew M McIntosh Heather C Whalley Christian Knöchel Viola Oertel-Knöchel Fleur M Howells Dan J Stein Henk S Temmingh Anne Uhlmann Carlos Lopez-Jaramillo Danai Dima Joshua I Faskowitz Boris A Gutman Neda Jahanshad Paul M Thompson Jessica A Turner

Biol Psychiatry 2019 04 22;85(7):e35-e39. Epub 2018 Nov 22.

Imaging Genetics and Neuroinformatics Laboratory, Department of Psychology, Georgia State University, Atlanta, Georgia; Mind Research Network, Albuquerque, New Mexico.

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http://dx.doi.org/10.1016/j.biopsych.2018.10.003DOI Listing
April 2019

An introduction to psychedelic neuroscience.

Prog Brain Res 2018 15;242:1-23. Epub 2018 Nov 15.

Translational Neuroscience Group, Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa; Neuroscience Institute, University of Cape Town, Cape Town, South Africa.

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https://linkinghub.elsevier.com/retrieve/pii/S00796123183011
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http://dx.doi.org/10.1016/bs.pbr.2018.09.013DOI Listing
March 2019

Food Cue Reactivity and the Brain-Heart Axis During Cognitive Stress Following Clinically Relevant Weight Loss.

Front Nutr 2018 4;5:135. Epub 2019 Jan 4.

Division of Exercise Science and Sports Medicine, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.3389/fnut.2018.00135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328490PMC
January 2019

Cortical Brain Abnormalities in 4474 Individuals With Schizophrenia and 5098 Control Subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium.

Authors:
Theo G M van Erp Esther Walton Derrek P Hibar Lianne Schmaal Wenhao Jiang David C Glahn Godfrey D Pearlson Nailin Yao Masaki Fukunaga Ryota Hashimoto Naohiro Okada Hidenaga Yamamori Juan R Bustillo Vincent P Clark Ingrid Agartz Bryon A Mueller Wiepke Cahn Sonja M C de Zwarte Hilleke E Hulshoff Pol René S Kahn Roel A Ophoff Neeltje E M van Haren Ole A Andreassen Anders M Dale Nhat Trung Doan Tiril P Gurholt Cecilie B Hartberg Unn K Haukvik Kjetil N Jørgensen Trine V Lagerberg Ingrid Melle Lars T Westlye Oliver Gruber Bernd Kraemer Anja Richter David Zilles Vince D Calhoun Benedicto Crespo-Facorro Roberto Roiz-Santiañez Diana Tordesillas-Gutiérrez Carmel Loughland Vaughan J Carr Stanley Catts Vanessa L Cropley Janice M Fullerton Melissa J Green Frans A Henskens Assen Jablensky Rhoshel K Lenroot Bryan J Mowry Patricia T Michie Christos Pantelis Yann Quidé Ulrich Schall Rodney J Scott Murray J Cairns Marc Seal Paul A Tooney Paul E Rasser Gavin Cooper Cynthia Shannon Weickert Thomas W Weickert Derek W Morris Elliot Hong Peter Kochunov Lauren M Beard Raquel E Gur Ruben C Gur Theodore D Satterthwaite Daniel H Wolf Aysenil Belger Gregory G Brown Judith M Ford Fabio Macciardi Daniel H Mathalon Daniel S O'Leary Steven G Potkin Adrian Preda James Voyvodic Kelvin O Lim Sarah McEwen Fude Yang Yunlong Tan Shuping Tan Zhiren Wang Fengmei Fan Jingxu Chen Hong Xiang Shiyou Tang Hua Guo Ping Wan Dong Wei Henry J Bockholt Stefan Ehrlich Rick P F Wolthusen Margaret D King Jody M Shoemaker Scott R Sponheim Lieuwe De Haan Laura Koenders Marise W Machielsen Therese van Amelsvoort Dick J Veltman Francesca Assogna Nerisa Banaj Pietro de Rossi Mariangela Iorio Fabrizio Piras Gianfranco Spalletta Peter J McKenna Edith Pomarol-Clotet Raymond Salvador Aiden Corvin Gary Donohoe Sinead Kelly Christopher D Whelan Erin W Dickie David Rotenberg Aristotle N Voineskos Simone Ciufolini Joaquim Radua Paola Dazzan Robin Murray Tiago Reis Marques Andrew Simmons Stefan Borgwardt Laura Egloff Fabienne Harrisberger Anita Riecher-Rössler Renata Smieskova Kathryn I Alpert Lei Wang Erik G Jönsson Sanne Koops Iris E C Sommer Alessandro Bertolino Aurora Bonvino Annabella Di Giorgio Emma Neilson Andrew R Mayer Julia M Stephen Jun Soo Kwon Je-Yeon Yun Dara M Cannon Colm McDonald Irina Lebedeva Alexander S Tomyshev Tolibjohn Akhadov Vasily Kaleda Helena Fatouros-Bergman Lena Flyckt Geraldo F Busatto Pedro G P Rosa Mauricio H Serpa Marcus V Zanetti Cyril Hoschl Antonin Skoch Filip Spaniel David Tomecek Saskia P Hagenaars Andrew M McIntosh Heather C Whalley Stephen M Lawrie Christian Knöchel Viola Oertel-Knöchel Michael Stäblein Fleur M Howells Dan J Stein Henk S Temmingh Anne Uhlmann Carlos Lopez-Jaramillo Danai Dima Agnes McMahon Joshua I Faskowitz Boris A Gutman Neda Jahanshad Paul M Thompson Jessica A Turner

Biol Psychiatry 2018 11 14;84(9):644-654. Epub 2018 May 14.

Imaging Genetics and Neuroinformatics Lab, Georgia State University, Atlanta, Georgia; Mind Research Network, Albuquerque, New Mexico.

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http://dx.doi.org/10.1016/j.biopsych.2018.04.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177304PMC
November 2018

Using structural MRI to identify bipolar disorders - 13 site machine learning study in 3020 individuals from the ENIGMA Bipolar Disorders Working Group.

Mol Psychiatry 2018 Aug 31. Epub 2018 Aug 31.

Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.

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http://dx.doi.org/10.1038/s41380-018-0228-9DOI Listing
August 2018

The impact of acute and short-term methamphetamine abstinence on brain metabolites: A proton magnetic resonance spectroscopy chemical shift imaging study.

Drug Alcohol Depend 2018 04 22;185:226-237. Epub 2018 Feb 22.

Department of Psychiatry and Mental Health, Groote Schuur Hospital, University of Cape Town, Anzio Rd., Observatory, 7925 Cape Town, South Africa; Neuroscience Institute, University of Cape Town, South Africa.

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http://dx.doi.org/10.1016/j.drugalcdep.2017.11.029DOI Listing
April 2018

Progress in neuroscience in Africa: editorial.

Metab Brain Dis 2018 04;33(2):357-358

Department of Psychiatry, Stellenbosch University, Stellenbosch, South Africa.

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http://dx.doi.org/10.1007/s11011-018-0213-7DOI Listing
April 2018

Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex.

Authors:
Tulio Guadalupe Samuel R Mathias Theo G M vanErp Christopher D Whelan Marcel P Zwiers Yoshinari Abe Lucija Abramovic Ingrid Agartz Ole A Andreassen Alejandro Arias-Vásquez Benjamin S Aribisala Nicola J Armstrong Volker Arolt Eric Artiges Rosa Ayesa-Arriola Vatche G Baboyan Tobias Banaschewski Gareth Barker Mark E Bastin Bernhard T Baune John Blangero Arun L W Bokde Premika S W Boedhoe Anushree Bose Silvia Brem Henry Brodaty Uli Bromberg Samantha Brooks Christian Büchel Jan Buitelaar Vince D Calhoun Dara M Cannon Anna Cattrell Yuqi Cheng Patricia J Conrod Annette Conzelmann Aiden Corvin Benedicto Crespo-Facorro Fabrice Crivello Udo Dannlowski Greig I de Zubicaray Sonja M C de Zwarte Ian J Deary Sylvane Desrivières Nhat Trung Doan Gary Donohoe Erlend S Dørum Stefan Ehrlich Thomas Espeseth Guillén Fernández Herta Flor Jean-Paul Fouche Vincent Frouin Masaki Fukunaga Jürgen Gallinat Hugh Garavan Michael Gill Andrea Gonzalez Suarez Penny Gowland Hans J Grabe Dominik Grotegerd Oliver Gruber Saskia Hagenaars Ryota Hashimoto Tobias U Hauser Andreas Heinz Derrek P Hibar Pieter J Hoekstra Martine Hoogman Fleur M Howells Hao Hu Hilleke E Hulshoff Pol Chaim Huyser Bernd Ittermann Neda Jahanshad Erik G Jönsson Sarah Jurk Rene S Kahn Sinead Kelly Bernd Kraemer Harald Kugel Jun Soo Kwon Herve Lemaitre Klaus-Peter Lesch Christine Lochner Michelle Luciano Andre F Marquand Nicholas G Martin Ignacio Martínez-Zalacaín Jean-Luc Martinot David Mataix-Cols Karen Mather Colm McDonald Katie L McMahon Sarah E Medland José M Menchón Derek W Morris Omar Mothersill Susana Munoz Maniega Benson Mwangi Takashi Nakamae Tomohiro Nakao Janardhanan C Narayanaswaamy Frauke Nees Jan E Nordvik A Marten H Onnink Nils Opel Roel Ophoff Marie-Laure Paillère Martinot Dimitri Papadopoulos Orfanos Paul Pauli Tomáš Paus Luise Poustka Janardhan Yc Reddy Miguel E Renteria Roberto Roiz-Santiáñez Annerine Roos Natalie A Royle Perminder Sachdev Pascual Sánchez-Juan Lianne Schmaal Gunter Schumann Elena Shumskaya Michael N Smolka Jair C Soares Carles Soriano-Mas Dan J Stein Lachlan T Strike Roberto Toro Jessica A Turner Nathalie Tzourio-Mazoyer Anne Uhlmann Maria Valdés Hernández Odile A van den Heuvel Dennis van der Meer Neeltje E M van Haren Dick J Veltman Ganesan Venkatasubramanian Nora C Vetter Daniella Vuletic Susanne Walitza Henrik Walter Esther Walton Zhen Wang Joanna Wardlaw Wei Wen Lars T Westlye Robert Whelan Katharina Wittfeld Thomas Wolfers Margaret J Wright Jian Xu Xiufeng Xu Je-Yeon Yun JingJing Zhao Barbara Franke Paul M Thompson David C Glahn Bernard Mazoyer Simon E Fisher Clyde Francks

Brain Imaging Behav 2017 Oct;11(5):1497-1514

Language & Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1007/s11682-016-9629-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540813PMC
October 2017

Current and potential pharmacological and psychosocial interventions for anxiety symptoms and disorders in patients with schizophrenia: structured review.

Hum Psychopharmacol 2017 09 15;32(5). Epub 2017 Aug 15.

Department of Psychiatry, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1002/hup.2628DOI Listing
September 2017

First-Rank Symptoms in Methamphetamine Psychosis and Schizophrenia.

Psychopathology 2016 8;49(6):429-435. Epub 2016 Dec 8.

Department of Psychiatry and Mental Health, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1159/000452476DOI Listing
March 2017

Genetically determined differences in noradrenergic function: The spontaneously hypertensive rat model.

Brain Res 2016 Jun 23;1641(Pt B):291-305. Epub 2015 Nov 23.

Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Observatory 7925, South Africa. Electronic address:

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http://dx.doi.org/10.1016/j.brainres.2015.11.019DOI Listing
June 2016

Alcohol exposure in utero is associated with decreased gray matter volume in neonates.

Metab Brain Dis 2016 Feb 29;31(1):81-91. Epub 2015 Nov 29.

Department of Psychiatry and Mental Health and MRC Unit on Anxiety & Stress Disorders, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1007/s11011-015-9771-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556617PMC
February 2016

Progress in neuroscience in Africa: editorial.

Metab Brain Dis 2016 Feb;31(1):1-2

Department of Human Biology, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1007/s11011-016-9790-5DOI Listing
February 2016

Can cognitive behaviour therapy beneficially influence arousal mechanisms in psychosis?

Hum Psychopharmacol 2016 Jan 13;31(1):64-9. Epub 2015 Aug 13.

Department of Psychiatry, University of Southampton, Southampton, UK.

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http://dx.doi.org/10.1002/hup.2499DOI Listing
January 2016

A study of the effects of prenatal alcohol exposure on white matter microstructural integrity at birth.

Acta Neuropsychiatr 2015 Aug 29;27(4):197-205. Epub 2015 May 29.

2MRC Unit on Anxiety & Stress Disorders,Stellenbosch University,Cape Town,South Africa.

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http://dx.doi.org/10.1017/neu.2015.35DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465963PMC
August 2015

(1)H-magnetic resonance spectroscopy in social anxiety disorder.

Prog Neuropsychopharmacol Biol Psychiatry 2015 Apr 27;58:97-104. Epub 2014 Dec 27.

MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, South Africa.

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http://dx.doi.org/10.1016/j.pnpbp.2014.12.008DOI Listing
April 2015

The neurobiology of methamphetamine induced psychosis.

Front Hum Neurosci 2014 22;8:537. Epub 2014 Jul 22.

Department of Psychiatry and Mental Health, University of Cape Town Western Cape, South Africa.

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http://dx.doi.org/10.3389/fnhum.2014.00537DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4105632PMC
August 2014

Nicotine-stimulated release of [3H]norepinephrine is reduced in the hippocampus of an animal model of attention-deficit/hyperactivity disorder, the spontaneously hypertensive rat.

Brain Res 2014 Jul 14;1572:1-10. Epub 2014 May 14.

Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Observatory, Cape Town 7925, South Africa.

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http://dx.doi.org/10.1016/j.brainres.2014.05.005DOI Listing
July 2014

Mindfulness based cognitive therapy may improve emotional processing in bipolar disorder: pilot ERP and HRV study.

Metab Brain Dis 2014 Jun 7;29(2):367-75. Epub 2013 Dec 7.

Department of Psychiatry, Faculty of Health Sciences, University of Cape Town, Observatory, 7925, South Africa,

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http://dx.doi.org/10.1007/s11011-013-9462-7DOI Listing
June 2014

Structural brain changes in prenatal methamphetamine-exposed children.

Metab Brain Dis 2014 Jun 20;29(2):341-9. Epub 2014 Feb 20.

MRC Unit on Anxiety & Stress Disorders, Department of Psychiatry, Stellenbosch University, P.O. Box 19063, Tygerberg, 7505, Cape Town, South Africa,

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http://dx.doi.org/10.1007/s11011-014-9500-0DOI Listing
June 2014

(1)H-magnetic resonance spectroscopy ((1)H-MRS) in methamphetamine dependence and methamphetamine induced psychosis.

Schizophr Res 2014 Mar 12;153(1-3):122-8. Epub 2014 Feb 12.

Department of Psychiatry and Mental Health, Faculty of Health Sciences, University of Cape Town, South Africa.

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http://dx.doi.org/10.1016/j.schres.2014.01.029DOI Listing
March 2014

Evidence for reduced tonic levels of GABA in the hippocampus of an animal model of ADHD, the spontaneously hypertensive rat.

Brain Res 2013 Dec 22;1541:52-60. Epub 2013 Oct 22.

Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Observatory 7925, South Africa. Electronic address:

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http://dx.doi.org/10.1016/j.brainres.2013.10.023DOI Listing
December 2013

Increased thalamic phospholipid concentration evident in bipolar I disorder.

Prog Neuropsychopharmacol Biol Psychiatry 2013 Mar 8;41:1-5. Epub 2012 Nov 8.

Department of Psychiatry, Faculty of Health Sciences, University of Cape Town, Observatory 7925, South Africa.

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http://dx.doi.org/10.1016/j.pnpbp.2012.10.026DOI Listing
March 2013

Maternal separation increases GABA(A) receptor-mediated modulation of norepinephrine release in the hippocampus of a rat model of ADHD, the spontaneously hypertensive rat.

Brain Res 2013 Feb 28;1497:23-31. Epub 2012 Dec 28.

Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Observatory, 7925, South Africa.

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http://dx.doi.org/10.1016/j.brainres.2012.12.029DOI Listing
February 2013

Synergistic tonic and phasic activity of the locus coeruleus norepinephrine (LC-NE) arousal system is required for optimal attentional performance.

Metab Brain Dis 2012 Sep 8;27(3):267-74. Epub 2012 Mar 8.

Department of Psychiatry, Faculty of Health Sciences, University of Cape Town, Observatory, 7925 Cape Town, South Africa.

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http://dx.doi.org/10.1007/s11011-012-9287-9DOI Listing
September 2012

Clozapine decreases exploratory activity and increases anxiety-like behaviour in the Wistar-Kyoto rat but not the spontaneously hypertensive rat model of attention-deficit/hyperactivity disorder.

Brain Res 2012 Jul 31;1467:91-103. Epub 2012 May 31.

Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Observatory, 7925, South Africa.

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http://dx.doi.org/10.1016/j.brainres.2012.05.047DOI Listing
July 2012

Mindfulness based cognitive therapy improves frontal control in bipolar disorder: a pilot EEG study.

BMC Psychiatry 2012 Feb 29;12:15. Epub 2012 Feb 29.

Department of Psychiatry, Faculty of Health Sciences, University of Cape Town, Observatory 7925, South Africa.

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http://dx.doi.org/10.1186/1471-244X-12-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3305658PMC
February 2012

Effects of early life trauma are dependent on genetic predisposition: a rat study.

Behav Brain Funct 2011 May 6;7:11. Epub 2011 May 6.

Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Observatory, 7925, South Africa.

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http://dx.doi.org/10.1186/1744-9081-7-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3104368PMC
May 2011

Perceived mental effort correlates with changes in tonic arousal during attentional tasks.

Behav Brain Funct 2010 Jul 8;6:39. Epub 2010 Jul 8.

Department of Psychiatry and Mental Health, Faculty of Health Sciences, University of Cape Town, Observatory 7925, South Africa.

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http://dx.doi.org/10.1186/1744-9081-6-39DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2909988PMC
July 2010

Increased glutamate-stimulated release of dopamine in substantia nigra of a rat model for attention-deficit/hyperactivity disorder--lack of effect of methylphenidate.

Metab Brain Dis 2009 Dec 10;24(4):599-613. Epub 2009 Oct 10.

Division of Physiology, Department of Human Biology, University of Cape Town, Observatory, Cape Town, 7925, South Africa.

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http://dx.doi.org/10.1007/s11011-009-9166-1DOI Listing
December 2009

Cross-fostering does not alter the neurochemistry or behavior of spontaneously hypertensive rats.

Behav Brain Funct 2009 Jun 23;5:24. Epub 2009 Jun 23.

Neuroscience Laboratory, Division of Physiology, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Observatory, 7925, South Africa.

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http://dx.doi.org/10.1186/1744-9081-5-24DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2711096PMC
June 2009

Stress reduces the neuroprotective effect of exercise in a rat model for Parkinson's disease.

Behav Brain Res 2005 Dec 12;165(2):210-20. Epub 2005 Sep 12.

Division of Physiology, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Observatory 7925, Room 5.02, Anatomy Building, South Africa.

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http://dx.doi.org/10.1016/j.bbr.2005.06.044DOI Listing
December 2005